SIMILAR PATTERNS OF AMINO ACIDS FOR 5E4D_B_BEZB201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		5 PHE A 302
TYR A 265
ILE A 262
ILE A 362
LEU A 318
 None
 0.94A 5e4dB-1cs1A:
1.1		 5e4dB-1cs1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL O   1
VAL O   3
ILE O 144
TYR O 137
LEU O 333
 None
 1.00A 5e4dB-1dbvO:
0.0		 5e4dB-1dbvO:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Giardia
intestinalis) 		PF00156
(Pribosyltran) 		5 VAL A  92
VAL A  94
ILE A 146
ILE A 137
LEU A 115
 None
 1.00A 5e4dB-1dqpA:
0.0		 5e4dB-1dqpA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1

(Homo sapiens) 		no annotation 5 VAL B1921
VAL B1874
VAL B1919
PHE B1869
LEU B1892
 None
 1.13A 5e4dB-1gzhB:
0.0		 5e4dB-1gzhB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1g TRANSCRIPTIONAL
REGULATOR LRPA

(Pyrococcus
furiosus) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		5 VAL A 128
VAL A  70
VAL A 131
ILE A 106
LEU A  84
 None
 0.89A 5e4dB-1i1gA:
2.4		 5e4dB-1i1gA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp0 CREATINE
AMIDINOHYDROLASE

(Actinobacillus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 VAL A 114
VAL A 110
ILE A 122
PHE A 144
LEU A 139
 None
 1.07A 5e4dB-1kp0A:
0.0		 5e4dB-1kp0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		5 VAL A  38
VAL A   7
ILE A 303
TRP A 336
LEU A 340
 None
 1.10A 5e4dB-1lwdA:
0.0		 5e4dB-1lwdA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 TYR A  96
ILE A 113
ILE A  72
PHE A 123
LEU A 137
 None
 0.93A 5e4dB-1m53A:
0.0		 5e4dB-1m53A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mld MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  73
VAL A   3
VAL A  71
PHE A 236
LEU A  20
 None
 1.08A 5e4dB-1mldA:
0.0		 5e4dB-1mldA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry6 INTERNAL KINESIN

(Plasmodium
falciparum) 		PF00225
(Kinesin) 		5 VAL A  54
VAL A   6
VAL A  57
ILE A  24
LEU A 322
 None
 0.97A 5e4dB-1ry6A:
undetectable		 5e4dB-1ry6A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhd ASPARTATE
1-DECARBOXYLASE
ALPHA CHAIN

(Helicobacter
pylori) 		PF02261
(Asp_decarbox) 		5 VAL A 105
VAL A 107
ILE A  26
ILE A  68
LEU A  32
 None
None
PYR  A  25 (-4.1A)
None
None
 1.10A 5e4dB-1uhdA:
undetectable		 5e4dB-1uhdA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		5 VAL A  99
VAL A 103
ILE A 159
ILE A  17
LEU A 114
 None
 0.98A 5e4dB-1vpeA:
undetectable		 5e4dB-1vpeA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 154
TYR A 219
ILE A 178
ILE A 161
LEU A 139
 None
 1.00A 5e4dB-1vzoA:
undetectable		 5e4dB-1vzoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		5 VAL A  91
VAL A 117
VAL A  93
PHE A  23
LEU A 265
 None
None
None
None
PGO  A 611 (-4.4A)
 1.10A 5e4dB-1womA:
undetectable		 5e4dB-1womA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zca G ALPHA I/12

(Mus musculus) 		PF00503
(G-alpha) 		5 VAL A 149
PHE A 145
ILE A  95
ILE A 187
LEU A 181
 None
 1.09A 5e4dB-1zcaA:
undetectable		 5e4dB-1zcaA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		5 VAL A 495
ILE A 534
PHE A 541
TRP A 516
LEU A 512
 None
 1.06A 5e4dB-2c3oA:
undetectable		 5e4dB-2c3oA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		5 VAL A  10
VAL A  64
VAL A   8
PHE A  55
LEU A  82
 None
 0.91A 5e4dB-2eg3A:
undetectable		 5e4dB-2eg3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm9 CELL INVASION
PROTEIN SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		5 VAL A 179
ILE A 261
ILE A 187
PHE A 258
LEU A 254
 None
 1.12A 5e4dB-2fm9A:
undetectable		 5e4dB-2fm9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix2 DNA POLYMERASE
SLIDING CLAMP B

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N) 		5 VAL A  72
ILE A  89
ILE A 100
TYR A   6
LEU A  28
 None
 1.00A 5e4dB-2ix2A:
undetectable		 5e4dB-2ix2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpe BPSL1050

(Burkholderia
pseudomallei) 		no annotation 5 VAL A 109
PHE A 111
ILE A  25
ILE A  51
LEU A 123
 None
 1.07A 5e4dB-2mpeA:
undetectable		 5e4dB-2mpeA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		5 VAL A 445
VAL A 444
ILE A 360
ILE A 424
LEU A 441
 None
 1.09A 5e4dB-2obmA:
undetectable		 5e4dB-2obmA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy1 PECTATE LYASE II

(Xanthomonas
campestris) 		PF00544
(Pec_lyase_C) 		6 VAL A 227
VAL A 249
PHE A 246
ILE A 241
ILE A 254
TYR A 219
 None
 1.26A 5e4dB-2qy1A:
undetectable		 5e4dB-2qy1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE

(Lactobacillus
plantarum) 		PF03807
(F420_oxidored) 		5 VAL A 130
VAL A 152
VAL A 128
PHE A 107
ILE A   3
 None
 1.07A 5e4dB-2rafA:
undetectable		 5e4dB-2rafA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 VAL A 670
VAL A 672
ILE A 638
ILE A 651
LEU A 625
 None
 0.95A 5e4dB-2vz9A:
undetectable		 5e4dB-2vz9A:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5r HYPOTHETICAL PROTEIN
ORF126

(Pyrobaculum
spherical virus) 		no annotation 5 VAL A  55
VAL A  21
VAL A  53
PHE A  43
TYR A 104
 None
 1.11A 5e4dB-2x5rA:
undetectable		 5e4dB-2x5rA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 VAL A 533
VAL A 531
ILE A 437
ILE A 502
LEU A 424
 None
 0.86A 5e4dB-2ycbA:
undetectable		 5e4dB-2ycbA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		5 VAL A 338
VAL A 366
ILE A 258
ILE A 412
LEU A 424
 None
 1.10A 5e4dB-3b2zA:
undetectable		 5e4dB-3b2zA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		5 VAL A4300
PHE A4323
ILE A4278
ILE A4325
LEU A4360
 None
 1.07A 5e4dB-3g1nA:
undetectable		 5e4dB-3g1nA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		5 VAL A 217
VAL A 191
VAL A 220
PHE A 234
LEU A 177
 None
 0.91A 5e4dB-3h3eA:
undetectable		 5e4dB-3h3eA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6q MACROCYPIN 1A

(Macrolepiota
procera) 		no annotation 5 VAL A  38
VAL A 145
VAL A  90
ILE A 109
ILE A 122
 None
 1.11A 5e4dB-3h6qA:
undetectable		 5e4dB-3h6qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6q MACROCYPIN 1A

(Macrolepiota
procera) 		no annotation 5 VAL A  90
VAL A  38
VAL A 145
ILE A 163
ILE A   9
 None
 1.09A 5e4dB-3h6qA:
undetectable		 5e4dB-3h6qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0z PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Streptococcus
pneumoniae) 		PF01380
(SIS) 		5 VAL A 111
VAL A 141
VAL A 113
TRP A  86
LEU A  46
 None
 1.04A 5e4dB-3i0zA:
undetectable		 5e4dB-3i0zA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2z LEXA REPRESSOR

(Thermotoga
maritima) 		PF00717
(Peptidase_S24)
PF01726
(LexA_DNA_bind) 		5 VAL A 131
VAL A 190
PHE A 111
ILE A  81
LEU A 155
 None
 1.10A 5e4dB-3k2zA:
undetectable		 5e4dB-3k2zA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2z LEXA REPRESSOR

(Thermotoga
maritima) 		PF00717
(Peptidase_S24)
PF01726
(LexA_DNA_bind) 		5 VAL A 190
VAL A 131
VAL A 193
ILE A 121
LEU A 155
 None
 1.09A 5e4dB-3k2zA:
undetectable		 5e4dB-3k2zA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00696
(AA_kinase) 		5 VAL A 123
VAL A 125
ILE A  28
ILE A   6
LEU A  38
 None
 1.07A 5e4dB-3ll5A:
undetectable		 5e4dB-3ll5A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 VAL A 227
VAL A 291
VAL A 225
ILE A 283
LEU A 307
 None
 0.89A 5e4dB-3lq1A:
undetectable		 5e4dB-3lq1A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		6 VAL A 510
PHE A 507
TYR A 414
ILE A 463
ILE A 466
LEU A 430
 None
 1.34A 5e4dB-3ps5A:
undetectable		 5e4dB-3ps5A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 VAL A 268
VAL A 263
ILE A 145
ILE A 254
LEU A 195
 None
 0.90A 5e4dB-3q2kA:
undetectable		 5e4dB-3q2kA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxz POLYSACCHARIDE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		PF01522
(Polysacc_deac_1) 		5 VAL A 265
VAL A  24
VAL A 267
PHE A 255
LEU A 224
 None
 0.80A 5e4dB-3rxzA:
undetectable		 5e4dB-3rxzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		5 VAL A 469
PHE A 387
ILE A 447
TYR A 410
LEU A 396
 VAL  A 469 ( 0.6A)
PHE  A 387 ( 1.3A)
ILE  A 447 ( 0.7A)
TYR  A 410 ( 1.3A)
LEU  A 396 ( 0.6A)
 1.10A 5e4dB-3sagA:
undetectable		 5e4dB-3sagA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Streptococcus
mutans) 		PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 VAL A 162
VAL A 135
ILE A 158
PHE A 283
LEU A 118
 None
 1.10A 5e4dB-3sqzA:
undetectable		 5e4dB-3sqzA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		5 VAL A  63
TYR A 156
ILE A 153
ILE A 121
LEU A  43
 None
 1.12A 5e4dB-3szbA:
undetectable		 5e4dB-3szbA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbj GALACTOSIDE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		5 VAL A 165
VAL A 150
ILE A 125
ILE A 126
LEU A 154
 None
 1.02A 5e4dB-3vbjA:
undetectable		 5e4dB-3vbjA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Escherichia
coli;
Archaeoglobus
fulgidus) 		PF13416
(SBP_bac_8) 		5 VAL A 793
VAL A 795
ILE A 864
ILE A 851
LEU A 868
 None
 0.96A 5e4dB-3waiA:
undetectable		 5e4dB-3waiA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		5 VAL A 793
VAL A 795
ILE A 864
ILE A 851
LEU A 868
 None
 0.95A 5e4dB-3wajA:
undetectable		 5e4dB-3wajA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		5 VAL A 425
VAL A 444
PHE A 403
ILE A 373
ILE A 454
 None
 1.00A 5e4dB-3wo8A:
undetectable		 5e4dB-3wo8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16415
(CNOT1_CAF1_bind) 		5 VAL A 935
VAL A 932
VAL A 931
ILE A 999
LEU A 962
 None
 1.05A 5e4dB-4b8aA:
undetectable		 5e4dB-4b8aA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0w FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Pseudomonas
putida) 		PF02525
(Flavodoxin_2) 		5 VAL A 135
VAL A 172
VAL A 137
TRP A  28
LEU A 199
 None
 1.04A 5e4dB-4c0wA:
undetectable		 5e4dB-4c0wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		5 VAL A 522
VAL A 612
VAL A 520
ILE A 630
LEU A 566
 None
 1.11A 5e4dB-4c4aA:
undetectable		 5e4dB-4c4aA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF01128
(IspD) 		5 VAL A 374
VAL A 339
VAL A 372
ILE A 431
LEU A 302
 None
 0.97A 5e4dB-4cvhA:
undetectable		 5e4dB-4cvhA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		5 VAL A1634
VAL A1648
VAL A1632
ILE A1564
LEU A1640
 None
 0.95A 5e4dB-4guaA:
undetectable		 5e4dB-4guaA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 VAL A 277
VAL A 267
VAL A 275
TYR A 176
ILE A 197
 None
 0.99A 5e4dB-4h1sA:
undetectable		 5e4dB-4h1sA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig8 2'-5'-OLIGOADENYLATE
SYNTHASE 1

(Homo sapiens) 		PF01909
(NTP_transf_2)
PF10421
(OAS1_C) 		5 VAL A  55
VAL A  80
VAL A  58
ILE A  37
PHE A  40
 G  B  17 ( 4.2A)
None
A  C   3 ( 4.3A)
None
None
 1.08A 5e4dB-4ig8A:
undetectable		 5e4dB-4ig8A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		5 VAL A 223
VAL A 218
ILE A 159
ILE A 166
LEU A 229
 None
 1.01A 5e4dB-4isaA:
undetectable		 5e4dB-4isaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg5 PUTATIVE CELL
ADHESION PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		5 VAL A  70
VAL A  68
ILE A 176
ILE A 180
LEU A  35
 None
 1.02A 5e4dB-4jg5A:
undetectable		 5e4dB-4jg5A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mct ANTIDOTE PROTEIN

(Proteus
vulgaris) 		PF01381
(HTH_3) 		5 VAL A  33
VAL A  38
PHE A  27
ILE A  13
LEU A  52
 None
 1.10A 5e4dB-4mctA:
undetectable		 5e4dB-4mctA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6b SERINE
ACETYLTRANSFERASE
APOENZYME

(Glycine max) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		5 VAL A 191
PHE A 167
ILE A 161
ILE A 155
LEU A 193
 None
 1.13A 5e4dB-4n6bA:
undetectable		 5e4dB-4n6bA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		5 VAL A 215
VAL A 218
VAL A 219
ILE A  97
ILE A 232
 None
 1.05A 5e4dB-4n7rA:
undetectable		 5e4dB-4n7rA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		5 VAL A 298
VAL A 301
VAL A 302
PHE A 210
LEU A 236
 None
 1.09A 5e4dB-4nz6A:
2.5		 5e4dB-4nz6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdi UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Acinetobacter
baumannii) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 400
VAL A 367
VAL A 398
ILE A 432
LEU A 458
 None
 1.05A 5e4dB-4qdiA:
undetectable		 5e4dB-4qdiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE

(Megavirus
chiliensis) 		PF02719
(Polysacc_synt_2) 		5 VAL A 166
VAL A 128
ILE A   8
ILE A  10
TYR A  25
 None
NDP  A 400 (-4.6A)
None
None
None
 1.05A 5e4dB-4tqgA:
undetectable		 5e4dB-4tqgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE

(Megavirus
chiliensis) 		PF02719
(Polysacc_synt_2) 		5 VAL A 166
VAL A 164
ILE A   3
ILE A  77
TYR A  25
 None
 0.98A 5e4dB-4tqgA:
undetectable		 5e4dB-4tqgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u88 TRANSCRIPTIONAL
REGULATOR SAER

(Staphylococcus
aureus) 		PF00486
(Trans_reg_C) 		5 VAL A  99
VAL A 104
VAL A  97
ILE A 167
ILE A 153
 None
 1.07A 5e4dB-4u88A:
undetectable		 5e4dB-4u88A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		5 VAL A 176
PHE A 166
ILE A 512
ILE A 162
TYR A 296
 None
 1.12A 5e4dB-4wyiA:
undetectable		 5e4dB-4wyiA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		5 VAL A 201
VAL A 199
TYR A 138
ILE A 154
LEU A  89
 None
 0.98A 5e4dB-4xprA:
undetectable		 5e4dB-4xprA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Thermotoga
maritima) 		PF01867
(Cas_Cas1) 		5 VAL A  44
PHE A  50
ILE A  59
ILE A  19
LEU A   6
 None
 0.98A 5e4dB-4xtkA:
undetectable		 5e4dB-4xtkA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		5 VAL A 394
VAL A 491
VAL A 392
ILE A 418
LEU A 413
 None
 0.97A 5e4dB-4z11A:
undetectable		 5e4dB-4z11A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		6 VAL A 149
VAL A 114
VAL A 147
ILE A  48
ILE A 164
LEU A  19
 None
 1.28A 5e4dB-4zu9A:
undetectable		 5e4dB-4zu9A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zvi DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 VAL A  69
VAL A  61
VAL A  71
PHE A  41
LEU A 187
 None
None
4S4  A 401 ( 4.9A)
None
None
 1.08A 5e4dB-4zviA:
undetectable		 5e4dB-4zviA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S RIBOSOMAL
PROTEIN L9

(Dictyostelium
discoideum) 		PF00347
(Ribosomal_L6) 		5 VAL B  20
VAL B  25
ILE B  68
ILE B  71
LEU B  53
 None
 0.98A 5e4dB-5an9B:
2.8		 5e4dB-5an9B:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cpg (R)-SPECIFIC
ENOYL-COA HYDRATASE

(Pseudomonas
aeruginosa) 		PF01575
(MaoC_dehydratas) 		5 VAL A 130
VAL A 121
ILE A  72
TYR A  83
LEU A  88
 None
 1.06A 5e4dB-5cpgA:
undetectable		 5e4dB-5cpgA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuo PHOSPHATE
PROPANOYLTRANSFERASE

(Rhodopseudomonas
palustris) 		PF06130
(PTAC) 		5 VAL A 110
VAL A 151
VAL A 108
ILE A 139
LEU A 118
 None
 1.12A 5e4dB-5cuoA:
undetectable		 5e4dB-5cuoA:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e4m HYDROXYNITRILE LYASE

(Davallia
tyermannii) 		no annotation 8 VAL A  48
VAL A  51
TYR A 101
ILE A 103
ILE A 108
PHE A 111
TYR A 117
TRP A 138
 None
None
HBA  A 201 (-4.6A)
None
None
HBA  A 201 (-3.5A)
HBA  A 201 (-4.6A)
HBA  A 201 ( 4.8A)
 1.41A 5e4dB-5e4mA:
31.2		 5e4dB-5e4mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e4m HYDROXYNITRILE LYASE

(Davallia
tyermannii) 		no annotation 11 VAL A  48
VAL A  51
VAL A  52
PHE A  71
TYR A 101
ILE A 103
ILE A 108
PHE A 111
TYR A 117
TRP A 138
LEU A 160
 None
None
None
HBA  A 201 ( 4.8A)
HBA  A 201 (-4.6A)
None
None
HBA  A 201 (-3.5A)
HBA  A 201 (-4.6A)
HBA  A 201 ( 4.8A)
HBA  A 201 ( 4.5A)
 0.43A 5e4dB-5e4mA:
31.2		 5e4dB-5e4mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		5 VAL A 224
VAL A 247
PHE A 241
ILE A 237
LEU A 317
 None
 1.11A 5e4dB-5eefA:
undetectable		 5e4dB-5eefA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A 278
VAL A 245
ILE A 252
ILE A 193
LEU A 268
 None
None
NAG  A1101 (-4.4A)
None
None
 1.04A 5e4dB-5fjiA:
undetectable		 5e4dB-5fjiA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A 278
VAL A 245
ILE A 252
ILE A 193
LEU A 268
 None
None
NAG  A1101 (-4.2A)
None
None
 1.07A 5e4dB-5fjjA:
undetectable		 5e4dB-5fjjA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 VAL A 207
VAL A 211
ILE A 387
TYR A 388
LEU A 191
 None
 1.05A 5e4dB-5fq6A:
undetectable		 5e4dB-5fq6A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5v FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Escherichia
coli) 		PF02465
(FliD_N)
PF07195
(FliD_C) 		5 VAL A 164
VAL A 180
ILE A 143
ILE A 153
LEU A 193
 None
 0.94A 5e4dB-5h5vA:
undetectable		 5e4dB-5h5vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Escherichia
coli) 		PF07195
(FliD_C)
PF07196
(Flagellin_IN) 		5 VAL A 164
VAL A 180
ILE A 143
ILE A 153
LEU A 193
 None
 0.89A 5e4dB-5h5wA:
undetectable		 5e4dB-5h5wA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx0 UNCHARACTERIZED
PROTEIN DFER_1899

(Dyadobacter
fermentans) 		PF13088
(BNR_2) 		5 VAL A 376
VAL A 378
ILE A  36
ILE A 352
LEU A 322
 None
 0.99A 5e4dB-5hx0A:
undetectable		 5e4dB-5hx0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilb PROTEASE DO-LIKE 2,
CHLOROPLASTIC,PROTEA
SE DO-LIKE 9

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 VAL A 512
VAL A 490
ILE A 443
PHE A 442
LEU A 526
 None
 0.87A 5e4dB-5ilbA:
undetectable		 5e4dB-5ilbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilb PROTEASE DO-LIKE 2,
CHLOROPLASTIC,PROTEA
SE DO-LIKE 9

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 VAL A 512
VAL A 490
VAL A 491
ILE A 443
PHE A 442
 None
 1.11A 5e4dB-5ilbA:
undetectable		 5e4dB-5ilbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 VAL A 311
VAL A 309
ILE A 493
ILE A 240
LEU A 324
 None
 1.12A 5e4dB-5kodA:
undetectable		 5e4dB-5kodA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		5 VAL A 248
VAL A 251
VAL A 252
PHE A 263
LEU A  64
 None
 0.93A 5e4dB-5svcA:
undetectable		 5e4dB-5svcA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uw2 PROBABLE
PHOSPHOLIPID ABC
TRANSPORTER-BINDING
PROTEIN MLAD

(Escherichia
coli) 		PF02470
(MlaD) 		5 VAL A  82
VAL A  68
ILE A  93
ILE A  86
LEU A 112
 None
 1.07A 5e4dB-5uw2A:
undetectable		 5e4dB-5uw2A:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0t PROTEIN MSP1

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 VAL A 255
ILE A  88
ILE A  93
PHE A  90
LEU A 103
 None
 0.97A 5e4dB-5w0tA:
undetectable		 5e4dB-5w0tA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 5 VAL A  23
VAL A  95
VAL A  21
ILE A  51
TRP A  58
 None
 1.07A 5e4dB-5wc2A:
undetectable		 5e4dB-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 5 VAL A  23
VAL A  95
VAL A  21
TRP A  58
LEU A  46
 None
 1.00A 5e4dB-5wc2A:
undetectable		 5e4dB-5wc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP1

(Hepatovirus A) 		PF12944
(HAV_VP) 		5 VAL A 153
PHE A 190
ILE A 145
ILE A 231
LEU A 243
 None
 1.01A 5e4dB-5wtfA:
undetectable		 5e4dB-5wtfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wth POLYPROTEIN

(Hepatovirus A) 		PF12944
(HAV_VP) 		5 VAL A 153
PHE A 190
ILE A 145
ILE A 231
LEU A 243
 None
 1.08A 5e4dB-5wthA:
undetectable		 5e4dB-5wthA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 5 VAL A  10
ILE A 128
ILE A 123
PHE A 127
LEU A  75
 None
 1.06A 5e4dB-5wyrA:
undetectable		 5e4dB-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpz FERMITIN FAMILY
HOMOLOG 2

(Mus musculus) 		PF00373
(FERM_M) 		5 VAL A  24
VAL A  31
VAL A  22
TRP A  58
LEU A  52
 None
 1.08A 5e4dB-5xpzA:
undetectable		 5e4dB-5xpzA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw6 P2X PURINOCEPTOR

(Gallus gallus) 		no annotation 5 VAL C  61
VAL C  63
PHE C  90
ILE C 222
PHE C 217
 None
 1.04A 5e4dB-5xw6C:
undetectable		 5e4dB-5xw6C:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyj ACETYL-COA
ACETYLTRANSFERASE

(Saccharomyces
cerevisiae) 		no annotation 5 VAL B 268
VAL B 264
ILE B  82
PHE B  51
LEU B  45
 None
 1.03A 5e4dB-5xyjB:
undetectable		 5e4dB-5xyjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 5 VAL A 526
VAL A 609
VAL A 524
ILE A 593
LEU A 622
 None
 1.06A 5e4dB-5yp3A:
undetectable		 5e4dB-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 5 VAL A 594
VAL A 625
VAL A 592
ILE A 492
LEU A 635
 None
 1.12A 5e4dB-5z0uA:
undetectable		 5e4dB-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 5 VAL A 492
ILE A 530
PHE A 537
TRP A 513
LEU A 509
 None
 1.06A 5e4dB-6cipA:
undetectable		 5e4dB-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A1259
VAL A   3
PHE A1310
ILE A 832
ILE A1343
 None
 1.11A 5e4dB-6eojA:
undetectable		 5e4dB-6eojA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewz GTP
PYROPHOSPHOKINASE

(Staphylococcus
aureus) 		no annotation 5 VAL A 113
VAL A 114
TYR A 151
ILE A 143
ILE A 121
 None
None
GTP  A 301 (-3.6A)
None
None
 1.06A 5e4dB-6ewzA:
undetectable		 5e4dB-6ewzA:
undetectable