SIMILAR PATTERNS OF AMINO ACIDS FOR 5E4D_A_BEZA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ck7 PROTEIN (GELATINASE
A)

(Homo sapiens) 		PF00040
(fn2)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 TYR A 581
ILE A 613
PHE A 631
TRP A 574
LEU A 640
 None
 1.44A 5e4dA-1ck7A:
undetectable		 5e4dA-1ck7A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		5 VAL A 107
VAL A 103
ILE A 152
PHE A 165
LEU A 163
 None
 1.36A 5e4dA-1edgA:
0.0		 5e4dA-1edgA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4o PEROXIREDOXIN 5

(Homo sapiens) 		PF08534
(Redoxin) 		5 VAL A  14
VAL A  12
PHE A 104
ILE A   9
PHE A  29
 None
 1.29A 5e4dA-1h4oA:
0.0		 5e4dA-1h4oA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		5 VAL A 453
VAL A 451
PHE A 495
TYR A 486
LEU A 515
 None
 1.26A 5e4dA-1hzvA:
0.5		 5e4dA-1hzvA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp0 CREATINE
AMIDINOHYDROLASE

(Actinobacillus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 VAL A 114
VAL A  69
ILE A 122
PHE A 144
LEU A 139
 None
 1.25A 5e4dA-1kp0A:
0.0		 5e4dA-1kp0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		5 VAL A 416
VAL A 425
TYR A 385
PHE A 440
LEU A 407
 None
 1.34A 5e4dA-1oltA:
0.0		 5e4dA-1oltA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442

(Thermotoga
maritima) 		PF01740
(STAS) 		5 VAL A  19
VAL A  17
PHE A  38
ILE A  47
PHE A  79
 None
 1.20A 5e4dA-1t6rA:
0.0		 5e4dA-1t6rA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		5 VAL A 495
ILE A 534
PHE A 541
TRP A 516
LEU A 512
 None
 1.08A 5e4dA-2c3oA:
0.0		 5e4dA-2c3oA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 VAL A 278
VAL A 280
PHE A 290
PHE A 242
LEU A 270
 None
 1.36A 5e4dA-2hxvA:
0.0		 5e4dA-2hxvA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		5 VAL A 276
VAL A 314
ILE A 374
PHE A 328
LEU A 390
 None
 1.47A 5e4dA-2nmpA:
undetectable		 5e4dA-2nmpA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy1 PECTATE LYASE II

(Xanthomonas
campestris) 		PF00544
(Pec_lyase_C) 		5 VAL A 227
VAL A 249
PHE A 246
ILE A 254
TYR A 219
 None
 1.30A 5e4dA-2qy1A:
undetectable		 5e4dA-2qy1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 382
VAL A 360
ILE A 346
PHE A 405
LEU A 331
 None
 1.23A 5e4dA-2yw2A:
undetectable		 5e4dA-2yw2A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zs0 EXTRACELLULAR GIANT
HEMOGLOBIN MAJOR
GLOBIN SUBUNIT B1

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		5 VAL D  68
VAL D  65
PHE D  61
PHE D  39
LEU D 110
 HEM  D 200 (-4.0A)
None
None
HEM  D 200 ( 4.7A)
HEM  D 200 (-3.8A)
 1.41A 5e4dA-2zs0D:
undetectable		 5e4dA-2zs0D:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayr ENDOGLUCANASE

(Piromyces
rhizinflatus) 		PF00150
(Cellulase) 		5 VAL A  95
VAL A  91
ILE A 136
PHE A 149
LEU A 147
 None
 1.39A 5e4dA-3ayrA:
undetectable		 5e4dA-3ayrA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		5 VAL A 380
VAL A 383
TYR A 153
TRP A 410
LEU A 370
 None
 1.45A 5e4dA-3dwcA:
undetectable		 5e4dA-3dwcA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		5 VAL A 337
PHE A 347
ILE A 391
PHE A 388
LEU A 319
 None
 1.38A 5e4dA-3eleA:
1.4		 5e4dA-3eleA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eua PUTATIVE
FRUCTOSE-AMINOACID-6
-PHOSPHATE DEGLYCASE

(Bacillus
subtilis) 		PF01380
(SIS) 		5 VAL A  77
VAL A  30
ILE A  64
PHE A  95
LEU A  71
 None
 1.35A 5e4dA-3euaA:
undetectable		 5e4dA-3euaA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5r FACT COMPLEX SUBUNIT
POB3

(Saccharomyces
cerevisiae) 		PF03531
(SSrecog)
PF17292
(POB3_N) 		5 VAL A  55
PHE A  93
ILE A  89
PHE A  81
LEU A  78
 None
 1.43A 5e4dA-3f5rA:
undetectable		 5e4dA-3f5rA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv1 DISULFIDE
INTERCHANGE PROTEIN

(Neisseria
gonorrhoeae) 		PF13098
(Thioredoxin_2) 		5 VAL A 142
VAL A 140
PHE A 237
ILE A 255
LEU A 154
 None
 1.30A 5e4dA-3gv1A:
undetectable		 5e4dA-3gv1A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mam OSMOPROTECTION
PROTEIN (PROX)

(Archaeoglobus
fulgidus) 		PF04069
(OpuAC) 		5 VAL A 115
VAL A 186
PHE A 164
ILE A 156
LEU A 204
 None
 1.24A 5e4dA-3mamA:
undetectable		 5e4dA-3mamA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 VAL A 510
PHE A 507
TYR A 414
ILE A 466
LEU A 430
 None
 1.39A 5e4dA-3ps5A:
undetectable		 5e4dA-3ps5A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 5 VAL A  16
PHE A  12
ILE A  72
PHE A  76
LEU A  81
 None
 1.46A 5e4dA-3q3hA:
undetectable		 5e4dA-3q3hA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r50 IPOMOELIN

(Ipomoea batatas) 		PF01419
(Jacalin) 		5 VAL A 144
VAL A  64
PHE A  54
ILE A  35
LEU A  49
 None
 1.48A 5e4dA-3r50A:
undetectable		 5e4dA-3r50A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		5 VAL A 517
VAL A 515
ILE A 531
PHE A 354
LEU A 356
 None
 1.33A 5e4dA-3sggA:
undetectable		 5e4dA-3sggA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up3 ACEDAF-12

(Ancylostoma
ceylanicum) 		PF00104
(Hormone_recep) 		5 VAL A 531
VAL A 534
PHE A 582
ILE A 581
LEU A 654
 None
 1.13A 5e4dA-3up3A:
undetectable		 5e4dA-3up3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfd SPASTIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 VAL A 505
VAL A 507
ILE A 344
PHE A 341
LEU A 354
 None
 1.35A 5e4dA-3vfdA:
undetectable		 5e4dA-3vfdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 VAL A 155
VAL A 163
ILE A  87
PHE A 108
LEU A 182
 None
 1.16A 5e4dA-3vtrA:
undetectable		 5e4dA-3vtrA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		5 VAL A 236
VAL A 232
ILE A 279
PHE A 292
LEU A 290
 None
 1.39A 5e4dA-3zmrA:
undetectable		 5e4dA-3zmrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		5 VAL A 133
VAL A 129
ILE A 175
PHE A 188
LEU A 186
 None
 1.39A 5e4dA-4im4A:
undetectable		 5e4dA-4im4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mct ANTIDOTE PROTEIN

(Proteus
vulgaris) 		PF01381
(HTH_3) 		5 VAL A  33
VAL A  38
PHE A  27
ILE A  13
LEU A  52
 None
 1.05A 5e4dA-4mctA:
undetectable		 5e4dA-4mctA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mcx ANTIDOTE PROTEIN

(Proteus
vulgaris) 		PF01381
(HTH_3) 		5 VAL A  33
VAL A  38
PHE A  27
ILE A  13
LEU A  52
 None
 1.09A 5e4dA-4mcxA:
undetectable		 5e4dA-4mcxA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf7 ENDO-1,4-BETA-GLUCAN
ASE CEL5C

(Butyrivibrio
proteoclasticus) 		PF00150
(Cellulase) 		5 VAL A 125
VAL A 121
ILE A 171
PHE A 184
LEU A 182
 None
 1.32A 5e4dA-4nf7A:
undetectable		 5e4dA-4nf7A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Pyrococcus
horikoshii) 		PF01259
(SAICAR_synt) 		5 VAL A  92
VAL A 117
ILE A 149
PHE A 178
LEU A 176
 None
 1.30A 5e4dA-4o7zA:
undetectable		 5e4dA-4o7zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptz FMN REDUCTASE SSUE

(Escherichia
coli) 		no annotation 5 VAL C  31
VAL C  33
ILE C  70
PHE C 167
LEU C 171
 None
 1.36A 5e4dA-4ptzC:
undetectable		 5e4dA-4ptzC:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 VAL A 295
PHE A  81
TYR A 125
TRP A 204
LEU A  82
 None
 1.31A 5e4dA-4qorA:
1.0		 5e4dA-4qorA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3a ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		5 VAL A 153
VAL A 149
ILE A 191
PHE A 204
LEU A 202
 None
 1.35A 5e4dA-4u3aA:
undetectable		 5e4dA-4u3aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8b EXO-XYLOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 VAL A 220
VAL A 216
ILE A 275
PHE A 288
LEU A 286
 None
 1.30A 5e4dA-4w8bA:
undetectable		 5e4dA-4w8bA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhg GH5

(Bacteroidetes
bacterium AC2a) 		PF00150
(Cellulase) 		5 VAL A  96
VAL A  92
ILE A 154
PHE A 167
LEU A 165
 None
 1.40A 5e4dA-4yhgA:
undetectable		 5e4dA-4yhgA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S RIBOSOMAL
PROTEIN L3

(Dictyostelium
discoideum) 		PF00297
(Ribosomal_L3) 		5 VAL A 161
VAL A 186
ILE A  86
PHE A 202
LEU A  89
 None
 1.38A 5e4dA-5an9A:
undetectable		 5e4dA-5an9A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5s ACETIC ACID

(Talaromyces
cellulolyticus) 		PF13472
(Lipase_GDSL_2) 		5 VAL A 124
VAL A  85
ILE A  73
TRP A 149
LEU A 112
 None
 1.26A 5e4dA-5b5sA:
undetectable		 5e4dA-5b5sA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii) 		PF00150
(Cellulase) 		5 VAL A  97
VAL A  93
ILE A 144
PHE A 157
LEU A 155
 None
 1.41A 5e4dA-5d9nA:
undetectable		 5e4dA-5d9nA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e4m HYDROXYNITRILE LYASE

(Davallia
tyermannii) 		no annotation 7 VAL A  48
VAL A  51
TYR A 101
ILE A 108
PHE A 111
TYR A 117
TRP A 138
 None
None
HBA  A 201 (-4.6A)
None
HBA  A 201 (-3.5A)
HBA  A 201 (-4.6A)
HBA  A 201 ( 4.8A)
 1.45A 5e4dA-5e4mA:
31.8		 5e4dA-5e4mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e4m HYDROXYNITRILE LYASE

(Davallia
tyermannii) 		no annotation 9 VAL A  48
VAL A  52
PHE A  71
TYR A 101
ILE A 108
PHE A 111
TYR A 117
TRP A 138
LEU A 160
 None
None
HBA  A 201 ( 4.8A)
HBA  A 201 (-4.6A)
None
HBA  A 201 (-3.5A)
HBA  A 201 (-4.6A)
HBA  A 201 ( 4.8A)
HBA  A 201 ( 4.5A)
 0.47A 5e4dA-5e4mA:
31.8		 5e4dA-5e4mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e4m HYDROXYNITRILE LYASE

(Davallia
tyermannii) 		no annotation 5 VAL A  51
PHE A  71
PHE A 111
TYR A 117
LEU A 160
 None
HBA  A 201 ( 4.8A)
HBA  A 201 (-3.5A)
HBA  A 201 (-4.6A)
HBA  A 201 ( 4.5A)
 1.49A 5e4dA-5e4mA:
31.8		 5e4dA-5e4mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5b FACT COMPLEX SUBUNIT
SPT16

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 VAL A  36
PHE A 137
ILE A 164
TRP A  55
LEU A  17
 None
 1.34A 5e4dA-5e5bA:
undetectable		 5e4dA-5e5bA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		5 VAL A 224
VAL A 247
PHE A 241
ILE A 237
LEU A 317
 None
 1.13A 5e4dA-5eefA:
undetectable		 5e4dA-5eefA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fui ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16

(Zobellia
galactanivorans) 		PF03422
(CBM_6) 		5 VAL A 358
VAL A 360
PHE A 305
ILE A 303
PHE A 367
 None
 1.46A 5e4dA-5fuiA:
undetectable		 5e4dA-5fuiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		5 VAL A  39
VAL A  29
TYR A  43
ILE A  97
LEU A 137
 None
 1.36A 5e4dA-5gqtA:
undetectable		 5e4dA-5gqtA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A 585
VAL A 563
TYR A 659
ILE A 431
LEU A 598
 None
 1.48A 5e4dA-5jp0A:
undetectable		 5e4dA-5jp0A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 5 VAL A 193
VAL A 189
ILE A 237
PHE A 250
LEU A 248
 None
 1.42A 5e4dA-5oydA:
undetectable		 5e4dA-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t95 PREPHENATE
DEHYDROGENASE 1

(Glycine max) 		PF02153
(PDH) 		5 VAL A  97
PHE A 157
ILE A  12
TRP A 136
LEU A  24
 None
 1.41A 5e4dA-5t95A:
undetectable		 5e4dA-5t95A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t95 PREPHENATE
DEHYDROGENASE 1

(Glycine max) 		PF02153
(PDH) 		5 VAL A  99
VAL A  97
PHE A 157
ILE A  12
LEU A  24
 None
 1.24A 5e4dA-5t95A:
undetectable		 5e4dA-5t95A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttx HYDROGENASE 2
MATURATION PEPTIDASE

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF01750
(HycI) 		5 VAL A 120
VAL A  61
PHE A  63
ILE A  49
LEU A 116
 None
 1.50A 5e4dA-5ttxA:
undetectable		 5e4dA-5ttxA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 VAL A 118
PHE A 174
ILE A 100
PHE A 155
LEU A 145
 None
 1.35A 5e4dA-5u47A:
undetectable		 5e4dA-5u47A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		5 VAL A 230
VAL A 228
ILE A 186
PHE A 127
LEU A 179
 None
None
None
None
TLA  A 402 (-4.0A)
 1.46A 5e4dA-5uibA:
undetectable		 5e4dA-5uibA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Neisseria
gonorrhoeae) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 384
VAL A 361
ILE A 349
PHE A 407
LEU A 334
 None
 1.24A 5e4dA-5vevA:
undetectable		 5e4dA-5vevA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 VAL A  42
PHE A  60
ILE A  64
PHE A 122
LEU A 105
 None
 1.20A 5e4dA-5y3rA:
undetectable		 5e4dA-5y3rA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 5 VAL A 492
ILE A 530
PHE A 537
TRP A 513
LEU A 509
 None
 1.07A 5e4dA-6cipA:
undetectable		 5e4dA-6cipA:
undetectable