SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_Z_BEZZ801_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermococcus
litoralis) 		PF01470
(Peptidase_C15) 		4 ILE A  66
GLY A  39
ILE A 198
LEU A   5
 None
 0.85A 5dzkl-1a2zA:
0.0
5dzkz-1a2zA:
undetectable		 5dzkl-1a2zA:
21.40
5dzkz-1a2zA:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu2 CYCLIN HOMOLOG

(Saimiriine
gammaherpesvirus
2) 		PF00134
(Cyclin_N)
PF09241
(Herp-Cyclin) 		4 ILE A  79
GLY A  98
ILE A 104
LEU A  80
 None
 0.86A 5dzkl-1bu2A:
undetectable
5dzkz-1bu2A:
undetectable		 5dzkl-1bu2A:
23.27
5dzkz-1bu2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 ILE A  47
GLY A  72
ILE A 130
LEU A  46
 None
 0.88A 5dzkl-1ddkA:
undetectable
5dzkz-1ddkA:
undetectable		 5dzkl-1ddkA:
23.17
5dzkz-1ddkA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ILE A 390
GLY A 311
ILE A 319
LEU A 310
 None
ATP  A 601 (-3.5A)
None
ATP  A 601 (-4.9A)
 0.80A 5dzkl-1gz4A:
1.5
5dzkz-1gz4A:
undetectable		 5dzkl-1gz4A:
16.64
5dzkz-1gz4A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		4 ILE A 233
GLY A 224
ILE A 244
LEU A 236
 None
 0.85A 5dzkl-1i2oA:
0.0
5dzkz-1i2oA:
undetectable		 5dzkl-1i2oA:
21.38
5dzkz-1i2oA:
0.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 ILE A 368
GLY A  52
ILE A  60
LEU A  48
 FAD  A2457 (-3.7A)
FAD  A2457 (-3.0A)
FAD  A2457 ( 3.5A)
FAD  A2457 (-2.9A)
 0.68A 5dzkl-1lqtA:
0.0
5dzkz-1lqtA:
undetectable		 5dzkl-1lqtA:
19.09
5dzkz-1lqtA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A  67
GLY A 107
ILE A  94
LEU A  66
 ANP  A1285 ( 4.9A)
ANP  A1285 (-3.2A)
None
ANP  A1285 (-4.0A)
 0.72A 5dzkl-1oj4A:
undetectable
5dzkz-1oj4A:
undetectable		 5dzkl-1oj4A:
21.23
5dzkz-1oj4A:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT

(Propionibacterium
freudenreichii) 		PF01039
(Carboxyl_trans) 		4 ILE A 404
GLY A 330
ILE A 500
LEU A 365
 None
 0.90A 5dzkl-1on9A:
11.8
5dzkz-1on9A:
undetectable		 5dzkl-1on9A:
17.42
5dzkz-1on9A:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea) 		PF01338
(Bac_thur_toxin) 		4 ILE A 103
GLY A  76
ILE A  82
LEU A 104
 None
 0.82A 5dzkl-1pp0A:
undetectable
5dzkz-1pp0A:
undetectable		 5dzkl-1pp0A:
19.63
5dzkz-1pp0A:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A 242
GLY A 224
ILE A 213
LEU A 225
 None
 0.90A 5dzkl-1r9jA:
undetectable
5dzkz-1r9jA:
undetectable		 5dzkl-1r9jA:
16.72
5dzkz-1r9jA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		4 ILE A 276
GLY A 356
ILE A 300
LEU A 315
 None
 0.85A 5dzkl-1rh9A:
undetectable
5dzkz-1rh9A:
undetectable		 5dzkl-1rh9A:
17.69
5dzkz-1rh9A:
0.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlv TRANSCRIPTION
ANTITERMINATOR LICT

(Bacillus
subtilis) 		PF00874
(PRD) 		4 ILE A 160
GLY A 154
ILE A 132
LEU A 158
 None
 0.85A 5dzkl-1tlvA:
undetectable
5dzkz-1tlvA:
undetectable		 5dzkl-1tlvA:
23.14
5dzkz-1tlvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		4 ILE A 122
GLY A 131
ILE A 143
LEU A  92
 None
 0.90A 5dzkl-1u9cA:
undetectable
5dzkz-1u9cA:
undetectable		 5dzkl-1u9cA:
22.50
5dzkz-1u9cA:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucv EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF00536
(SAM_1) 		4 ILE A  50
GLY A  54
ILE A  59
LEU A  52
 None
 0.83A 5dzkl-1ucvA:
undetectable
5dzkz-1ucvA:
undetectable		 5dzkl-1ucvA:
21.74
5dzkz-1ucvA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		4 ILE A 251
GLY A  24
ILE A  67
LEU A  76
 None
 0.87A 5dzkl-1us4A:
undetectable
5dzkz-1us4A:
undetectable		 5dzkl-1us4A:
23.77
5dzkz-1us4A:
0.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arf WILSON DISEASE
ATPASE

(Homo sapiens) 		PF00702
(Hydrolase) 		4 ILE A1194
GLY A1072
ILE A1180
LEU A1071
 None
 0.85A 5dzkl-2arfA:
undetectable
5dzkz-2arfA:
undetectable		 5dzkl-2arfA:
22.22
5dzkz-2arfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6y FORKHEAD BOX PROTEIN
K2

(Homo sapiens) 		PF00250
(Forkhead) 		4 ILE A  12
GLY A  28
ILE A  51
LEU A  24
 None
 0.79A 5dzkl-2c6yA:
undetectable
5dzkz-2c6yA:
undetectable		 5dzkl-2c6yA:
20.31
5dzkz-2c6yA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1d TRANSALDOLASE

(Mus musculus) 		PF00923
(TAL_FSA) 		4 ILE A 244
GLY A 235
ILE A 255
LEU A 247
 None
 0.84A 5dzkl-2e1dA:
undetectable
5dzkz-2e1dA:
undetectable		 5dzkl-2e1dA:
20.59
5dzkz-2e1dA:
0.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eao EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF00536
(SAM_1) 		4 ILE A  65
GLY A  69
ILE A  74
LEU A  67
 None
 0.89A 5dzkl-2eaoA:
undetectable
5dzkz-2eaoA:
undetectable		 5dzkl-2eaoA:
18.59
5dzkz-2eaoA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		4 ILE A 219
GLY A 184
ILE A 214
LEU A 220
 None
 0.86A 5dzkl-2gdzA:
undetectable
5dzkz-2gdzA:
undetectable		 5dzkl-2gdzA:
21.07
5dzkz-2gdzA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE

(Enterococcus
faecalis) 		PF02525
(Flavodoxin_2) 		4 ILE A 100
GLY A 177
ILE A 163
LEU A 144
 None
 0.90A 5dzkl-2hpvA:
undetectable
5dzkz-2hpvA:
undetectable		 5dzkl-2hpvA:
24.35
5dzkz-2hpvA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF08612
(Med20)
PF09637
(Med18) 		4 ILE A 115
GLY B 206
ILE A  46
LEU B 207
 None
 0.84A 5dzkl-2hzsA:
undetectable
5dzkz-2hzsA:
undetectable		 5dzkl-2hzsA:
22.61
5dzkz-2hzsA:
0.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		4 ILE A  62
GLY A  11
ILE A  88
LEU A  38
 None
 0.71A 5dzkl-2i5bA:
1.9
5dzkz-2i5bA:
undetectable		 5dzkl-2i5bA:
21.69
5dzkz-2i5bA:
1.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icg LIN2918 PROTEIN

(Listeria
innocua) 		PF14568
(SUKH_6) 		4 ILE A  99
GLY A 144
ILE A 110
LEU A 147
 None
 0.71A 5dzkl-2icgA:
undetectable
5dzkz-2icgA:
undetectable		 5dzkl-2icgA:
21.29
5dzkz-2icgA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3w ZGC 92866

(Danio rerio) 		PF04051
(TRAPP) 		4 ILE B  89
GLY B 144
ILE B 150
LEU B 170
 None
 0.89A 5dzkl-2j3wB:
undetectable
5dzkz-2j3wB:
undetectable		 5dzkl-2j3wB:
24.19
5dzkz-2j3wB:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 ILE A 113
GLY A   6
ILE A 115
LEU A  87
 None
 0.87A 5dzkl-2jjmA:
3.2
5dzkz-2jjmA:
undetectable		 5dzkl-2jjmA:
19.90
5dzkz-2jjmA:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nan CD302 ANTIGEN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 ILE A  89
GLY A  92
ILE A  75
LEU A  90
 None
 0.87A 5dzkl-2nanA:
undetectable
5dzkz-2nanA:
undetectable		 5dzkl-2nanA:
21.03
5dzkz-2nanA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 348
GLY A 104
ILE A 499
LEU A 107
 None
 0.76A 5dzkl-2nz9A:
undetectable
5dzkz-2nz9A:
undetectable		 5dzkl-2nz9A:
8.76
5dzkz-2nz9A:
0.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		4 ILE A 223
GLY A 139
ILE A 180
LEU A 193
 None
 0.65A 5dzkl-2qvlA:
undetectable
5dzkz-2qvlA:
undetectable		 5dzkl-2qvlA:
21.41
5dzkz-2qvlA:
0.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		4 ILE A 293
GLY A 308
ILE A  56
LEU A 309
 None
 0.89A 5dzkl-2rinA:
undetectable
5dzkz-2rinA:
undetectable		 5dzkl-2rinA:
20.21
5dzkz-2rinA:
0.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ILE A1200
GLY A1195
ILE A1466
LEU A1199
 None
 0.81A 5dzkl-2xkkA:
undetectable
5dzkz-2xkkA:
undetectable		 5dzkl-2xkkA:
14.91
5dzkz-2xkkA:
1.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE

(Enterococcus
faecalis) 		PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2) 		4 ILE A  97
GLY A  94
ILE A  91
LEU A  96
 None
 0.87A 5dzkl-3cj8A:
undetectable
5dzkz-3cj8A:
undetectable		 5dzkl-3cj8A:
24.18
5dzkz-3cj8A:
0.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ILE A 180
GLY A 124
ILE A 132
LEU A 123
 None
 0.90A 5dzkl-3dooA:
undetectable
5dzkz-3dooA:
undetectable		 5dzkl-3dooA:
22.26
5dzkz-3dooA:
0.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 ILE A 502
GLY A 592
ILE A 526
LEU A 554
 None
 0.71A 5dzkl-3eqnA:
undetectable
5dzkz-3eqnA:
undetectable		 5dzkl-3eqnA:
13.33
5dzkz-3eqnA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 311
GLY A  68
ILE A 333
LEU A  67
 None
 0.87A 5dzkl-3gazA:
undetectable
5dzkz-3gazA:
undetectable		 5dzkl-3gazA:
19.41
5dzkz-3gazA:
0.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ILE B 900
GLY B 886
ILE B 899
LEU B 887
 None
 0.87A 5dzkl-3h0gB:
undetectable
5dzkz-3h0gB:
undetectable		 5dzkl-3h0gB:
10.26
5dzkz-3h0gB:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfi PUTATIVE REGULATOR

(Escherichia
coli) 		PF07702
(UTRA) 		4 ILE A  95
GLY A  80
ILE A  73
LEU A  98
 None
 0.87A 5dzkl-3hfiA:
undetectable
5dzkz-3hfiA:
undetectable		 5dzkl-3hfiA:
24.42
5dzkz-3hfiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		4 ILE A 463
GLY A 478
ILE A 466
LEU A 481
 None
FMN  A1002 (-3.7A)
None
FMN  A1002 ( 4.9A)
 0.77A 5dzkl-3i6rA:
2.2
5dzkz-3i6rA:
undetectable		 5dzkl-3i6rA:
18.45
5dzkz-3i6rA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icx PRE MRNA SPLICING
PROTEIN

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 ILE A 280
GLY A 274
ILE A 319
LEU A 278
 None
 0.89A 5dzkl-3icxA:
undetectable
5dzkz-3icxA:
undetectable		 5dzkl-3icxA:
22.90
5dzkz-3icxA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io5 RECOMBINATION AND
REPAIR PROTEIN

(Escherichia
virus T4) 		PF00154
(RecA) 		4 ILE A  41
GLY A  50
ILE A  47
LEU A  43
 None
 0.82A 5dzkl-3io5A:
undetectable
5dzkz-3io5A:
undetectable		 5dzkl-3io5A:
23.03
5dzkz-3io5A:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 227
GLY A 251
ILE A 109
LEU A 252
 None
 0.81A 5dzkl-3kb6A:
undetectable
5dzkz-3kb6A:
undetectable		 5dzkl-3kb6A:
20.81
5dzkz-3kb6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ILE A 345
GLY A  49
ILE A 389
LEU A  52
 None
 0.69A 5dzkl-3lk6A:
undetectable
5dzkz-3lk6A:
undetectable		 5dzkl-3lk6A:
16.31
5dzkz-3lk6A:
0.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC

(Escherichia
coli) 		no annotation 4 ILE A 302
GLY A 334
ILE A 294
LEU A 300
 None
 0.79A 5dzkl-3ly9A:
undetectable
5dzkz-3ly9A:
undetectable		 5dzkl-3ly9A:
18.82
5dzkz-3ly9A:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		4 ILE A  49
GLY A  44
ILE A 118
LEU A  47
 None
 0.84A 5dzkl-3mx3A:
undetectable
5dzkz-3mx3A:
undetectable		 5dzkl-3mx3A:
18.13
5dzkz-3mx3A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne7 ACETYLTRANSFERASE

(Thermoplasma
acidophilum) 		PF00583
(Acetyltransf_1) 		4 ILE A  75
GLY A  67
ILE A 103
LEU A  74
 None
None
COA  A 161 (-4.9A)
None
 0.90A 5dzkl-3ne7A:
undetectable
5dzkz-3ne7A:
undetectable		 5dzkl-3ne7A:
21.63
5dzkz-3ne7A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of5 DETHIOBIOTIN
SYNTHETASE

(Francisella
tularensis) 		PF13500
(AAA_26) 		4 ILE A 172
GLY A   8
ILE A  18
LEU A 142
 None
 0.70A 5dzkl-3of5A:
undetectable
5dzkz-3of5A:
undetectable		 5dzkl-3of5A:
20.75
5dzkz-3of5A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 ILE B 409
GLY B 213
ILE B 299
LEU B 212
 None
 0.88A 5dzkl-3ojyB:
undetectable
5dzkz-3ojyB:
undetectable		 5dzkl-3ojyB:
17.97
5dzkz-3ojyB:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION

(Bifidobacterium
adolescentis) 		PF13556
(HTH_30) 		4 ILE A  85
GLY A  57
ILE A  71
LEU A  93
 None
 0.89A 5dzkl-3onqA:
undetectable
5dzkz-3onqA:
undetectable		 5dzkl-3onqA:
22.94
5dzkz-3onqA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN

(Yersinia pestis) 		PF01557
(FAA_hydrolase) 		4 ILE A 206
GLY A  97
ILE A  54
LEU A 208
 None
 0.90A 5dzkl-3s52A:
undetectable
5dzkz-3s52A:
undetectable		 5dzkl-3s52A:
24.57
5dzkz-3s52A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3see HYPOTHETICAL SUGAR
BINDING PROTEIN

(Bacteroides
thetaiotaomicron) 		PF15425
(DUF4627) 		4 ILE A 214
GLY A 216
ILE A 225
LEU A 215
 None
 0.86A 5dzkl-3seeA:
undetectable
5dzkz-3seeA:
undetectable		 5dzkl-3seeA:
20.43
5dzkz-3seeA:
1.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 ILE A 291
GLY A 246
ILE A 231
LEU A 222
 None
 0.83A 5dzkl-3tm5A:
undetectable
5dzkz-3tm5A:
undetectable		 5dzkl-3tm5A:
21.76
5dzkz-3tm5A:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 ILE A 680
GLY A 849
ILE A 670
LEU A 678
 None
 0.78A 5dzkl-3tsyA:
undetectable
5dzkz-3tsyA:
undetectable		 5dzkl-3tsyA:
13.31
5dzkz-3tsyA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS

(Pyrococcus
furiosus) 		PF08489
(DUF1743) 		4 ILE A  64
GLY A 100
ILE A  69
LEU A   2
 None
 0.74A 5dzkl-3u02A:
undetectable
5dzkz-3u02A:
undetectable		 5dzkl-3u02A:
21.69
5dzkz-3u02A:
1.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4g ARGININE REPRESSOR

(Vibrio
vulnificus) 		PF01316
(Arg_repressor)
PF02863
(Arg_repressor_C) 		4 ILE A 108
GLY A 101
ILE A 131
LEU A  85
 None
 0.89A 5dzkl-3v4gA:
undetectable
5dzkz-3v4gA:
undetectable		 5dzkl-3v4gA:
19.81
5dzkz-3v4gA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 ILE L  12
GLY L  43
ILE L 112
LEU L  42
 None
 0.78A 5dzkl-3wxrL:
undetectable
5dzkz-3wxrL:
undetectable		 5dzkl-3wxrL:
20.20
5dzkz-3wxrL:
1.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		4 ILE A 482
GLY A 579
ILE A 515
LEU A 564
 None
 0.90A 5dzkl-4bugA:
undetectable
5dzkz-4bugA:
undetectable		 5dzkl-4bugA:
16.74
5dzkz-4bugA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE

(Lachnoclostridium
phytofermentans) 		PF00171
(Aldedh) 		4 ILE A 343
GLY A 364
ILE A 298
LEU A 363
 None
 0.89A 5dzkl-4c3sA:
undetectable
5dzkz-4c3sA:
undetectable		 5dzkl-4c3sA:
21.43
5dzkz-4c3sA:
0.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4e ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Escherichia
coli) 		PF00227
(Proteasome) 		4 ILE A 105
GLY A  45
ILE A 120
LEU A  95
 None
 0.79A 5dzkl-4g4eA:
undetectable
5dzkz-4g4eA:
undetectable		 5dzkl-4g4eA:
21.74
5dzkz-4g4eA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ILE A 408
GLY A 391
ILE A 366
LEU A 407
 15P  A 504 ( 4.9A)
None
None
None
 0.89A 5dzkl-4grhA:
undetectable
5dzkz-4grhA:
undetectable		 5dzkl-4grhA:
18.95
5dzkz-4grhA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		4 ILE B  61
GLY B 231
ILE B 155
LEU B 232
 None
 0.85A 5dzkl-4hdsB:
2.4
5dzkz-4hdsB:
undetectable		 5dzkl-4hdsB:
21.64
5dzkz-4hdsB:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg9 LIPOPROTEIN

(Bacillus
anthracis) 		PF16167
(DUF4871) 		4 ILE A 171
GLY A 153
ILE A  82
LEU A 154
 None
 0.81A 5dzkl-4jg9A:
undetectable
5dzkz-4jg9A:
undetectable		 5dzkl-4jg9A:
18.72
5dzkz-4jg9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		4 ILE A  13
GLY A 141
ILE A 283
LEU A 153
 None
 0.76A 5dzkl-4l6uA:
undetectable
5dzkz-4l6uA:
undetectable		 5dzkl-4l6uA:
19.03
5dzkz-4l6uA:
0.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg8 PRE-MRNA-PROCESSING
FACTOR 19

(Homo sapiens) 		PF00400
(WD40) 		4 ILE A 459
GLY A 453
ILE A 490
LEU A 452
 None
 0.63A 5dzkl-4lg8A:
undetectable
5dzkz-4lg8A:
undetectable		 5dzkl-4lg8A:
20.50
5dzkz-4lg8A:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1j CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		4 ILE A  96
GLY A 159
ILE A 169
LEU A  98
 None
 0.90A 5dzkl-4o1jA:
undetectable
5dzkz-4o1jA:
undetectable		 5dzkl-4o1jA:
25.47
5dzkz-4o1jA:
1.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Mesorhizobium
japonicum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ILE A 101
GLY A  74
ILE A   8
LEU A 104
 None
None
NAD  A 402 (-4.6A)
None
 0.81A 5dzkl-4om8A:
undetectable
5dzkz-4om8A:
undetectable		 5dzkl-4om8A:
20.19
5dzkz-4om8A:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ILE A 565
GLY A 594
ILE A 485
LEU A 564
 None
 0.81A 5dzkl-4pj3A:
undetectable
5dzkz-4pj3A:
undetectable		 5dzkl-4pj3A:
8.86
5dzkz-4pj3A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3n MGS-M5

(unidentified) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A  77
GLY A 143
ILE A 100
LEU A 117
 None
 0.76A 5dzkl-4q3nA:
undetectable
5dzkz-4q3nA:
undetectable		 5dzkl-4q3nA:
21.91
5dzkz-4q3nA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM

(Vespa basalis) 		PF00151
(Lipase) 		4 ILE A 190
GLY A 135
ILE A 180
LEU A 164
 None
 0.88A 5dzkl-4qnnA:
undetectable
5dzkz-4qnnA:
undetectable		 5dzkl-4qnnA:
20.27
5dzkz-4qnnA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qv9 PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 ILE K  12
GLY K  43
ILE K 112
LEU K  42
 None
 0.78A 5dzkl-4qv9K:
undetectable
5dzkz-4qv9K:
undetectable		 5dzkl-4qv9K:
22.13
5dzkz-4qv9K:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF13407
(Peripla_BP_4) 		4 ILE A 213
GLY A 237
ILE A 168
LEU A 211
 None
 0.82A 5dzkl-4rxtA:
undetectable
5dzkz-4rxtA:
undetectable		 5dzkl-4rxtA:
23.08
5dzkz-4rxtA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ttp DEPHOSPHO-COA KINASE

(Legionella
pneumophila) 		PF01121
(CoaE) 		4 ILE A  36
GLY A  12
ILE A 102
LEU A 115
 None
 0.72A 5dzkl-4ttpA:
undetectable
5dzkz-4ttpA:
undetectable		 5dzkl-4ttpA:
24.29
5dzkz-4ttpA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		4 ILE A 254
GLY A 249
ILE A 201
LEU A 252
 None
 0.83A 5dzkl-4tx8A:
undetectable
5dzkz-4tx8A:
undetectable		 5dzkl-4tx8A:
17.31
5dzkz-4tx8A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzr PUTATIVE
UNCHARACTERIZED
PROTEIN PH1500

(Pyrococcus
horikoshii) 		PF02933
(CDC48_2) 		4 ILE A 109
GLY A 120
ILE A 146
LEU A 108
 None
 0.90A 5dzkl-4uzrA:
undetectable
5dzkz-4uzrA:
undetectable		 5dzkl-4uzrA:
20.79
5dzkz-4uzrA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ILE A 849
GLY A 702
ILE A 951
LEU A 735
 None
 0.87A 5dzkl-4w8jA:
1.3
5dzkz-4w8jA:
undetectable		 5dzkl-4w8jA:
10.44
5dzkz-4w8jA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxk PHYCOBILIPROTEIN
APCE

(Nostoc sp. PCC
7120) 		PF00502
(Phycobilisome) 		4 ILE A  56
GLY A  50
ILE A 225
LEU A  54
 None
 0.75A 5dzkl-4xxkA:
undetectable
5dzkz-4xxkA:
undetectable		 5dzkl-4xxkA:
24.10
5dzkz-4xxkA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 ILE A 105
GLY A   5
ILE A 336
LEU A  82
 None
 0.88A 5dzkl-4xywA:
undetectable
5dzkz-4xywA:
undetectable		 5dzkl-4xywA:
19.41
5dzkz-4xywA:
0.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Streptobacillus
moniliformis) 		PF13407
(Peripla_BP_4) 		4 ILE A 113
GLY A  30
ILE A 289
LEU A  88
 None
 0.85A 5dzkl-4z0nA:
undetectable
5dzkz-4z0nA:
undetectable		 5dzkl-4z0nA:
20.47
5dzkz-4z0nA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis) 		no annotation 4 ILE A 359
GLY A 368
ILE A 387
LEU A 361
 None
 0.88A 5dzkl-4z38A:
2.6
5dzkz-4z38A:
undetectable		 5dzkl-4z38A:
17.06
5dzkz-4z38A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 ILE M 243
GLY M 234
ILE M 208
LEU M 241
 None
 0.74A 5dzkl-5a5tM:
undetectable
5dzkz-5a5tM:
undetectable		 5dzkl-5a5tM:
21.97
5dzkz-5a5tM:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3r IMP-18

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A  65
GLY A  90
ILE A 148
LEU A  64
 None
 0.88A 5dzkl-5b3rA:
undetectable
5dzkz-5b3rA:
undetectable		 5dzkl-5b3rA:
22.27
5dzkz-5b3rA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE

(Hirschia
baltica) 		PF00160
(Pro_isomerase) 		4 ILE A  49
GLY A 189
ILE A 168
LEU A  48
 None
 0.90A 5dzkl-5ex1A:
undetectable
5dzkz-5ex1A:
undetectable		 5dzkl-5ex1A:
19.30
5dzkz-5ex1A:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ILE C 122
GLY C  88
ILE C 451
LEU C  70
 None
 0.85A 5dzkl-5fseC:
1.9
5dzkz-5fseC:
undetectable		 5dzkl-5fseC:
15.72
5dzkz-5fseC:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 4 ILE A 103
GLY A 216
ILE A 168
LEU A 161
 None
 0.82A 5dzkl-5gqfA:
undetectable
5dzkz-5gqfA:
undetectable		 5dzkl-5gqfA:
14.08
5dzkz-5gqfA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		4 ILE A 152
GLY A 111
ILE A 122
LEU A 155
 None
 0.87A 5dzkl-5hasA:
undetectable
5dzkz-5hasA:
undetectable		 5dzkl-5hasA:
17.36
5dzkz-5hasA:
1.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 ILE S 198
GLY S  58
ILE S 190
LEU S 169
 None
 0.79A 5dzkl-5k0yS:
undetectable
5dzkz-5k0yS:
undetectable		 5dzkl-5k0yS:
19.26
5dzkz-5k0yS:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB) 		4 ILE A 435
GLY A 413
ILE A 264
LEU A 290
 None
 0.90A 5dzkl-5kwaA:
2.9
5dzkz-5kwaA:
undetectable		 5dzkl-5kwaA:
19.05
5dzkz-5kwaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly6 PNEUMOLYSIN

(Streptococcus
pneumoniae) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 ILE B 329
GLY B 326
ILE B 198
LEU B 327
 None
 0.77A 5dzkl-5ly6B:
undetectable
5dzkz-5ly6B:
undetectable		 5dzkl-5ly6B:
17.83
5dzkz-5ly6B:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2

(Porphyromonas
gingivalis) 		no annotation 4 ILE B 281
GLY B 270
ILE B 312
LEU B 273
 None
 0.78A 5dzkl-5nfiB:
undetectable
5dzkz-5nfiB:
undetectable		 5dzkl-5nfiB:
undetectable
5dzkz-5nfiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		4 ILE A 158
GLY A 182
ILE A 169
LEU A 122
 None
B12  A 802 (-3.4A)
None
None
 0.86A 5dzkl-5ul4A:
undetectable
5dzkz-5ul4A:
undetectable		 5dzkl-5ul4A:
13.31
5dzkz-5ul4A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		no annotation 4 ILE A 341
GLY A 350
ILE A 406
LEU A 351
 None
 0.89A 5dzkl-5umsA:
undetectable
5dzkz-5umsA:
undetectable		 5dzkl-5umsA:
undetectable
5dzkz-5umsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE

(Pseudomonas
aeruginosa) 		PF06833
(MdcE) 		4 ILE A 133
GLY A 246
ILE A 238
LEU A 155
 None
 0.89A 5dzkl-5vipA:
9.3
5dzkz-5vipA:
undetectable		 5dzkl-5vipA:
25.09
5dzkz-5vipA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vto BLASTICIDIN M

(Streptomyces
griseochromogenes) 		no annotation 4 ILE A 106
GLY A 134
ILE A 116
LEU A 131
 None
 0.86A 5dzkl-5vtoA:
undetectable
5dzkz-5vtoA:
undetectable		 5dzkl-5vtoA:
undetectable
5dzkz-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1

(Homo sapiens) 		no annotation 4 ILE B 131
GLY B 114
ILE B  51
LEU B 115
 None
 0.83A 5dzkl-5wy8B:
undetectable
5dzkz-5wy8B:
undetectable		 5dzkl-5wy8B:
undetectable
5dzkz-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER

(Pseudomonas
aeruginosa) 		no annotation 4 ILE B 209
GLY B  33
ILE B 224
LEU B  34
 None
 0.84A 5dzkl-5x5yB:
undetectable
5dzkz-5x5yB:
undetectable		 5dzkl-5x5yB:
23.48
5dzkz-5x5yB:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 4 ILE C 245
GLY C 429
ILE C 433
LEU C 407
 None
 0.78A 5dzkl-5x6xC:
undetectable
5dzkz-5x6xC:
undetectable		 5dzkl-5x6xC:
undetectable
5dzkz-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		4 ILE A 437
GLY A 431
ILE A 152
LEU A 435
 None
 0.82A 5dzkl-5x9rA:
undetectable
5dzkz-5x9rA:
undetectable		 5dzkl-5x9rA:
19.86
5dzkz-5x9rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ILE A 445
GLY A 368
ILE A 376
LEU A 367
 None
 0.82A 5dzkl-5zqzA:
8.4
5dzkz-5zqzA:
undetectable		 5dzkl-5zqzA:
undetectable
5dzkz-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6d -

(-) 		no annotation 4 ILE A  86
GLY A 113
ILE A  92
LEU A 114
 None
 0.80A 5dzkl-6d6dA:
undetectable
5dzkz-6d6dA:
undetectable		 5dzkl-6d6dA:
undetectable
5dzkz-6d6dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Saccharomyces
cerevisiae) 		no annotation 4 ILE O 164
GLY O 126
ILE O 282
LEU O 130
 None
 0.89A 5dzkl-6eu2O:
undetectable
5dzkz-6eu2O:
undetectable		 5dzkl-6eu2O:
undetectable
5dzkz-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 ILE A 257
GLY A 250
ILE A 304
LEU A 254
 None
 0.83A 5dzkl-6eu6A:
undetectable
5dzkz-6eu6A:
undetectable		 5dzkl-6eu6A:
undetectable
5dzkz-6eu6A:
undetectable