SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_X_BEZX801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermococcus
litoralis) 		PF01470
(Peptidase_C15) 		4 ILE A  66
GLY A  39
ILE A 198
LEU A   5
 None
 0.85A 5dzki-1a2zA:
0.0
5dzkj-1a2zA:
0.0
5dzkx-1a2zA:
undetectable		 5dzki-1a2zA:
21.40
5dzkj-1a2zA:
21.40
5dzkx-1a2zA:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR

(Escherichia
coli) 		PF12849
(PBP_like_2) 		4 ILE A 260
GLY A  68
ILE A 312
LEU A  69
 None
 0.87A 5dzki-1a40A:
undetectable
5dzkj-1a40A:
undetectable
5dzkx-1a40A:
undetectable		 5dzki-1a40A:
20.12
5dzkj-1a40A:
20.12
5dzkx-1a40A:
0.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 307
GLY A 359
ILE A  48
LEU A 310
 None
 0.86A 5dzki-1bkhA:
0.5
5dzkj-1bkhA:
2.2
5dzkx-1bkhA:
undetectable		 5dzki-1bkhA:
22.13
5dzkj-1bkhA:
22.13
5dzkx-1bkhA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu2 CYCLIN HOMOLOG

(Saimiriine
gammaherpesvirus
2) 		PF00134
(Cyclin_N)
PF09241
(Herp-Cyclin) 		4 ILE A  79
GLY A  98
ILE A 104
LEU A  80
 None
 0.82A 5dzki-1bu2A:
undetectable
5dzkj-1bu2A:
undetectable
5dzkx-1bu2A:
undetectable		 5dzki-1bu2A:
23.27
5dzkj-1bu2A:
23.27
5dzkx-1bu2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 ARG A 225
ILE A 197
ILE A 220
LEU A 191
 None
 0.87A 5dzki-1d0nA:
0.0
5dzkj-1d0nA:
0.0
5dzkx-1d0nA:
undetectable		 5dzki-1d0nA:
14.50
5dzkj-1d0nA:
14.50
5dzkx-1d0nA:
1.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2i PROTEIN (RESTRICTION
ENDONUCLEASE BGLII)

(Bacillus
subtilis) 		PF09195
(Endonuc-BglII) 		4 ILE A 128
GLY A  86
ILE A  23
LEU A  91
 None
 0.76A 5dzki-1d2iA:
undetectable
5dzkj-1d2iA:
undetectable
5dzkx-1d2iA:
undetectable		 5dzki-1d2iA:
24.39
5dzkj-1d2iA:
24.39
5dzkx-1d2iA:
1.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE

(Bacillus
subtilis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 ILE A 222
GLY A 157
ILE A 170
LEU A 156
 None
 0.89A 5dzki-1dkrA:
0.1
5dzkj-1dkrA:
3.2
5dzkx-1dkrA:
undetectable		 5dzki-1dkrA:
21.91
5dzkj-1dkrA:
21.91
5dzkx-1dkrA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		4 ILE A 281
GLY A 307
ILE A 292
LEU A 393
 None
 0.88A 5dzki-1f0xA:
0.0
5dzkj-1f0xA:
undetectable
5dzkx-1f0xA:
undetectable		 5dzki-1f0xA:
16.64
5dzkj-1f0xA:
16.64
5dzkx-1f0xA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		4 ILE A 233
GLY A 224
ILE A 244
LEU A 236
 None
 0.84A 5dzki-1i2oA:
0.0
5dzkj-1i2oA:
0.0
5dzkx-1i2oA:
undetectable		 5dzki-1i2oA:
21.38
5dzkj-1i2oA:
21.38
5dzkx-1i2oA:
0.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 ILE A 368
GLY A  52
ILE A  60
LEU A  48
 FAD  A2457 (-3.7A)
FAD  A2457 (-3.0A)
FAD  A2457 ( 3.5A)
FAD  A2457 (-2.9A)
 0.78A 5dzki-1lqtA:
undetectable
5dzkj-1lqtA:
undetectable
5dzkx-1lqtA:
undetectable		 5dzki-1lqtA:
19.09
5dzkj-1lqtA:
19.09
5dzkx-1lqtA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 ILE A 103
GLY A 125
ILE A  75
LEU A  40
 None
 0.82A 5dzki-1miqA:
undetectable
5dzkj-1miqA:
undetectable
5dzkx-1miqA:
undetectable		 5dzki-1miqA:
19.52
5dzkj-1miqA:
19.52
5dzkx-1miqA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A  67
GLY A 107
ILE A  94
LEU A  66
 ANP  A1285 ( 4.9A)
ANP  A1285 (-3.2A)
None
ANP  A1285 (-4.0A)
 0.81A 5dzki-1oj4A:
undetectable
5dzkj-1oj4A:
undetectable
5dzkx-1oj4A:
undetectable		 5dzki-1oj4A:
21.23
5dzkj-1oj4A:
21.23
5dzkx-1oj4A:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT

(Propionibacterium
freudenreichii) 		PF01039
(Carboxyl_trans) 		4 ILE A 404
GLY A 330
ILE A 500
LEU A 365
 None
 0.89A 5dzki-1on9A:
11.8
5dzkj-1on9A:
11.8
5dzkx-1on9A:
undetectable		 5dzki-1on9A:
17.42
5dzkj-1on9A:
17.42
5dzkx-1on9A:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea) 		PF01338
(Bac_thur_toxin) 		4 ILE A 103
GLY A  76
ILE A  82
LEU A 104
 None
 0.74A 5dzki-1pp0A:
undetectable
5dzkj-1pp0A:
undetectable
5dzkx-1pp0A:
undetectable		 5dzki-1pp0A:
19.63
5dzkj-1pp0A:
19.63
5dzkx-1pp0A:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		4 ILE A 170
GLY A 163
ILE A 178
LEU A 166
 None
 0.85A 5dzki-1pxyA:
undetectable
5dzkj-1pxyA:
undetectable
5dzkx-1pxyA:
undetectable		 5dzki-1pxyA:
18.31
5dzkj-1pxyA:
18.31
5dzkx-1pxyA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 ARG G 225
ILE G 197
ILE G 220
LEU G 191
 None
 0.85A 5dzki-1rgiG:
undetectable
5dzkj-1rgiG:
undetectable
5dzkx-1rgiG:
undetectable		 5dzki-1rgiG:
19.43
5dzkj-1rgiG:
19.43
5dzkx-1rgiG:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 ILE A 159
GLY A 152
ILE A 167
LEU A 155
 None
 0.78A 5dzki-1rt8A:
undetectable
5dzkj-1rt8A:
undetectable
5dzkx-1rt8A:
undetectable		 5dzki-1rt8A:
17.60
5dzkj-1rt8A:
17.60
5dzkx-1rt8A:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0t INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Mycobacterium
tuberculosis) 		PF01513
(NAD_kinase) 		4 ILE A 264
GLY A 166
ILE A 245
LEU A 253
 None
 0.88A 5dzki-1u0tA:
undetectable
5dzkj-1u0tA:
undetectable
5dzkx-1u0tA:
undetectable		 5dzki-1u0tA:
23.15
5dzkj-1u0tA:
23.15
5dzkx-1u0tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucv EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF00536
(SAM_1) 		4 ILE A  50
GLY A  54
ILE A  59
LEU A  52
 None
 0.84A 5dzki-1ucvA:
undetectable
5dzkj-1ucvA:
undetectable
5dzkx-1ucvA:
undetectable		 5dzki-1ucvA:
21.74
5dzkj-1ucvA:
21.74
5dzkx-1ucvA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzf LIPASE/ACYLHYDROLASE

(Enterococcus
faecalis) 		PF13472
(Lipase_GDSL_2) 		4 ARG A 189
ILE A 108
GLY A 139
LEU A 109
 None
 0.88A 5dzki-1yzfA:
undetectable
5dzkj-1yzfA:
undetectable
5dzkx-1yzfA:
undetectable		 5dzki-1yzfA:
22.90
5dzkj-1yzfA:
22.90
5dzkx-1yzfA:
1.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z87 ALPHA-1-SYNTROPHIN

(Mus musculus) 		PF00595
(PDZ) 		4 ILE A  96
GLY A 126
ILE A  94
LEU A 107
 ILE  A  96 ( 0.6A)
GLY  A 126 ( 0.0A)
ILE  A  94 ( 0.6A)
LEU  A 107 ( 0.6A)
 0.88A 5dzki-1z87A:
undetectable
5dzkj-1z87A:
undetectable
5dzkx-1z87A:
undetectable		 5dzki-1z87A:
22.18
5dzkj-1z87A:
22.18
5dzkx-1z87A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arf WILSON DISEASE
ATPASE

(Homo sapiens) 		PF00702
(Hydrolase) 		4 ILE A1194
GLY A1072
ILE A1180
LEU A1071
 None
 0.86A 5dzki-2arfA:
undetectable
5dzkj-2arfA:
undetectable
5dzkx-2arfA:
undetectable		 5dzki-2arfA:
22.22
5dzkj-2arfA:
22.22
5dzkx-2arfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1d TRANSALDOLASE

(Mus musculus) 		PF00923
(TAL_FSA) 		4 ILE A 244
GLY A 235
ILE A 255
LEU A 247
 None
 0.85A 5dzki-2e1dA:
undetectable
5dzkj-2e1dA:
undetectable
5dzkx-2e1dA:
undetectable		 5dzki-2e1dA:
20.59
5dzkj-2e1dA:
20.59
5dzkx-2e1dA:
0.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		4 ARG A 554
ILE A 597
GLY A 602
LEU A 598
 None
 0.85A 5dzki-2et6A:
undetectable
5dzkj-2et6A:
undetectable
5dzkx-2et6A:
undetectable		 5dzki-2et6A:
16.14
5dzkj-2et6A:
16.14
5dzkx-2et6A:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2c PUTATIVE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN

(Corynebacterium
diphtheriae) 		PF00994
(MoCF_biosynth) 		4 ILE A  70
GLY A 122
ILE A  59
LEU A 132
 None
 0.83A 5dzki-2g2cA:
undetectable
5dzkj-2g2cA:
undetectable
5dzkx-2g2cA:
undetectable		 5dzki-2g2cA:
24.39
5dzkj-2g2cA:
24.39
5dzkx-2g2cA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		4 ILE A 171
GLY A 206
ILE A 151
LEU A 205
 None
 0.83A 5dzki-2g8lA:
undetectable
5dzkj-2g8lA:
undetectable
5dzkx-2g8lA:
undetectable		 5dzki-2g8lA:
18.60
5dzkj-2g8lA:
18.60
5dzkx-2g8lA:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpv FMN-DEPENDENT
NADH-AZOREDUCTASE

(Enterococcus
faecalis) 		PF02525
(Flavodoxin_2) 		4 ILE A 100
GLY A 177
ILE A 163
LEU A 144
 None
 0.87A 5dzki-2hpvA:
undetectable
5dzkj-2hpvA:
undetectable
5dzkx-2hpvA:
undetectable		 5dzki-2hpvA:
24.35
5dzkj-2hpvA:
24.35
5dzkx-2hpvA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20
RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF08612
(Med20)
PF09637
(Med18) 		4 ILE A 115
GLY B 206
ILE A  46
LEU B 207
 None
 0.88A 5dzki-2hzsA:
undetectable
5dzkj-2hzsA:
undetectable
5dzkx-2hzsA:
undetectable		 5dzki-2hzsA:
22.61
5dzkj-2hzsA:
22.61
5dzkx-2hzsA:
0.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		4 ILE A  62
GLY A  11
ILE A  88
LEU A  38
 None
 0.66A 5dzki-2i5bA:
undetectable
5dzkj-2i5bA:
1.9
5dzkx-2i5bA:
undetectable		 5dzki-2i5bA:
21.69
5dzkj-2i5bA:
21.69
5dzkx-2i5bA:
1.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nan CD302 ANTIGEN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 ILE A  89
GLY A  92
ILE A  75
LEU A  90
 None
 0.74A 5dzki-2nanA:
undetectable
5dzkj-2nanA:
undetectable
5dzkx-2nanA:
undetectable		 5dzki-2nanA:
21.03
5dzkj-2nanA:
21.03
5dzkx-2nanA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2r POLY(RC)-BINDING
PROTEIN 2

(Homo sapiens) 		PF00013
(KH_1) 		4 ARG A 333
ILE A 323
GLY A 307
ILE A 299
 None
 0.79A 5dzki-2p2rA:
undetectable
5dzkj-2p2rA:
undetectable
5dzkx-2p2rA:
undetectable		 5dzki-2p2rA:
22.78
5dzkj-2p2rA:
22.78
5dzkx-2p2rA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgo PUTATIVE FE-S
BIOSYNTHESIS PROTEIN

(Lactobacillus
acidophilus) 		PF01521
(Fe-S_biosyn) 		4 ARG A  19
ILE A  21
GLY A 115
ILE A 112
 None
 0.88A 5dzki-2qgoA:
undetectable
5dzkj-2qgoA:
undetectable
5dzkx-2qgoA:
undetectable		 5dzki-2qgoA:
18.48
5dzkj-2qgoA:
18.48
5dzkx-2qgoA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		4 ILE A 223
GLY A 139
ILE A 180
LEU A 193
 None
 0.65A 5dzki-2qvlA:
undetectable
5dzkj-2qvlA:
undetectable
5dzkx-2qvlA:
undetectable		 5dzki-2qvlA:
21.41
5dzkj-2qvlA:
21.41
5dzkx-2qvlA:
0.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		4 ILE A 293
GLY A 308
ILE A  56
LEU A 309
 None
 0.86A 5dzki-2rinA:
undetectable
5dzkj-2rinA:
undetectable
5dzkx-2rinA:
undetectable		 5dzki-2rinA:
20.21
5dzkj-2rinA:
20.21
5dzkx-2rinA:
0.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF03308
(ArgK) 		4 ILE A 228
GLY A 233
ILE A 239
LEU A 229
 None
 0.88A 5dzki-2wwwA:
undetectable
5dzkj-2wwwA:
undetectable
5dzkx-2wwwA:
undetectable		 5dzki-2wwwA:
22.19
5dzkj-2wwwA:
22.19
5dzkx-2wwwA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ILE A1200
GLY A1195
ILE A1466
LEU A1199
 None
 0.77A 5dzki-2xkkA:
undetectable
5dzkj-2xkkA:
undetectable
5dzkx-2xkkA:
undetectable		 5dzki-2xkkA:
14.91
5dzkj-2xkkA:
14.91
5dzkx-2xkkA:
1.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
synthetic
construct) 		PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		4 ILE C 348
GLY C 416
ILE C 412
LEU C 350
 None
None
None
GSU  C1001 (-3.8A)
 0.80A 5dzki-3al0C:
undetectable
5dzkj-3al0C:
undetectable
5dzkx-3al0C:
undetectable		 5dzki-3al0C:
15.62
5dzkj-3al0C:
15.62
5dzkx-3al0C:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		4 ILE A 244
GLY A 222
ILE A 235
LEU A 243
 None
 0.88A 5dzki-3anyA:
undetectable
5dzkj-3anyA:
undetectable
5dzkx-3anyA:
undetectable		 5dzki-3anyA:
19.02
5dzkj-3anyA:
19.02
5dzkx-3anyA:
0.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ILE A 180
GLY A 124
ILE A 132
LEU A 123
 None
 0.83A 5dzki-3dooA:
undetectable
5dzkj-3dooA:
undetectable
5dzkx-3dooA:
undetectable		 5dzki-3dooA:
22.26
5dzkj-3dooA:
22.26
5dzkx-3dooA:
0.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 ILE A 502
GLY A 592
ILE A 526
LEU A 554
 None
 0.77A 5dzki-3eqnA:
undetectable
5dzkj-3eqnA:
undetectable
5dzkx-3eqnA:
undetectable		 5dzki-3eqnA:
13.33
5dzkj-3eqnA:
13.33
5dzkx-3eqnA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A  22
ILE A  21
GLY A 332
LEU A 336
 None
 0.85A 5dzki-3fj4A:
3.4
5dzkj-3fj4A:
2.0
5dzkx-3fj4A:
undetectable		 5dzki-3fj4A:
21.37
5dzkj-3fj4A:
21.37
5dzkx-3fj4A:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 ILE A 111
GLY A 108
ILE A 101
LEU A 110
 None
 0.86A 5dzki-3h0lA:
undetectable
5dzkj-3h0lA:
undetectable
5dzkx-3h0lA:
undetectable		 5dzki-3h0lA:
17.44
5dzkj-3h0lA:
17.44
5dzkx-3h0lA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		4 ILE A  70
GLY A 228
ILE A   9
LEU A 226
 None
 0.89A 5dzki-3h6eA:
undetectable
5dzkj-3h6eA:
undetectable
5dzkx-3h6eA:
undetectable		 5dzki-3h6eA:
18.57
5dzkj-3h6eA:
18.57
5dzkx-3h6eA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5a RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 ARG A 132
ILE A 131
GLY A  35
ILE A  42
 None
 0.76A 5dzki-3i5aA:
undetectable
5dzkj-3i5aA:
undetectable
5dzkx-3i5aA:
undetectable		 5dzki-3i5aA:
20.85
5dzkj-3i5aA:
20.85
5dzkx-3i5aA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		4 ILE A 463
GLY A 478
ILE A 466
LEU A 481
 None
FMN  A1002 (-3.7A)
None
FMN  A1002 ( 4.9A)
 0.87A 5dzki-3i6rA:
undetectable
5dzkj-3i6rA:
undetectable
5dzkx-3i6rA:
undetectable		 5dzki-3i6rA:
18.45
5dzkj-3i6rA:
18.45
5dzkx-3i6rA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg5 B-CELL ANTIGEN
RECEPTOR
COMPLEX-ASSOCIATED
PROTEIN BETA CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ARG A  95
ILE A 112
GLY A 118
ILE A 109
 None
 0.81A 5dzki-3kg5A:
undetectable
5dzkj-3kg5A:
undetectable
5dzkx-3kg5A:
undetectable		 5dzki-3kg5A:
18.23
5dzkj-3kg5A:
18.23
5dzkx-3kg5A:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kho B-CELL ANTIGEN
RECEPTOR
COMPLEX-ASSOCIATED
PROTEIN BETA CHAIN

(Mus musculus) 		no annotation 4 ARG B  93
ILE B 110
GLY B 116
ILE B 107
 None
 0.80A 5dzki-3khoB:
undetectable
5dzkj-3khoB:
undetectable
5dzkx-3khoB:
undetectable		 5dzki-3khoB:
19.12
5dzkj-3khoB:
19.12
5dzkx-3khoB:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ILE A 345
GLY A  49
ILE A 389
LEU A  52
 None
 0.79A 5dzki-3lk6A:
undetectable
5dzkj-3lk6A:
undetectable
5dzkx-3lk6A:
undetectable		 5dzki-3lk6A:
16.31
5dzkj-3lk6A:
16.31
5dzkx-3lk6A:
0.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of5 DETHIOBIOTIN
SYNTHETASE

(Francisella
tularensis) 		PF13500
(AAA_26) 		4 ILE A 172
GLY A   8
ILE A  18
LEU A 142
 None
 0.67A 5dzki-3of5A:
undetectable
5dzkj-3of5A:
undetectable
5dzkx-3of5A:
undetectable		 5dzki-3of5A:
20.75
5dzkj-3of5A:
20.75
5dzkx-3of5A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION

(Bifidobacterium
adolescentis) 		PF13556
(HTH_30) 		4 ILE A  85
GLY A  57
ILE A  71
LEU A  93
 None
 0.84A 5dzki-3onqA:
undetectable
5dzkj-3onqA:
undetectable
5dzkx-3onqA:
undetectable		 5dzki-3onqA:
22.94
5dzkj-3onqA:
22.94
5dzkx-3onqA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ILE A 443
GLY A 476
ILE A 514
LEU A 461
 None
 0.88A 5dzki-3rr5A:
undetectable
5dzkj-3rr5A:
undetectable
5dzkx-3rr5A:
undetectable		 5dzki-3rr5A:
16.31
5dzkj-3rr5A:
16.31
5dzkx-3rr5A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 ILE A 291
GLY A 246
ILE A 231
LEU A 222
 None
 0.89A 5dzki-3tm5A:
undetectable
5dzkj-3tm5A:
undetectable
5dzkx-3tm5A:
undetectable		 5dzki-3tm5A:
21.76
5dzkj-3tm5A:
21.76
5dzkx-3tm5A:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS

(Pyrococcus
furiosus) 		PF08489
(DUF1743) 		4 ILE A  64
GLY A 100
ILE A  69
LEU A   2
 None
 0.74A 5dzki-3u02A:
undetectable
5dzkj-3u02A:
undetectable
5dzkx-3u02A:
undetectable		 5dzki-3u02A:
21.69
5dzkj-3u02A:
21.69
5dzkx-3u02A:
1.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4g ARGININE REPRESSOR

(Vibrio
vulnificus) 		PF01316
(Arg_repressor)
PF02863
(Arg_repressor_C) 		4 ILE A 108
GLY A 101
ILE A 131
LEU A  85
 None
 0.84A 5dzki-3v4gA:
undetectable
5dzkj-3v4gA:
undetectable
5dzkx-3v4gA:
undetectable		 5dzki-3v4gA:
19.81
5dzkj-3v4gA:
19.81
5dzkx-3v4gA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 ILE L  12
GLY L  43
ILE L 112
LEU L  42
 None
 0.73A 5dzki-3wxrL:
undetectable
5dzkj-3wxrL:
undetectable
5dzkx-3wxrL:
undetectable		 5dzki-3wxrL:
20.20
5dzkj-3wxrL:
20.20
5dzkx-3wxrL:
1.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 ARG A 209
ILE A 205
GLY A 229
ILE A 222
 None
 0.88A 5dzki-4b09A:
undetectable
5dzkj-4b09A:
undetectable
5dzkx-4b09A:
undetectable		 5dzki-4b09A:
22.39
5dzkj-4b09A:
22.39
5dzkx-4b09A:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A  67
ILE A 141
GLY A 176
ILE A  64
 None
 0.89A 5dzki-4e3cA:
undetectable
5dzkj-4e3cA:
undetectable
5dzkx-4e3cA:
undetectable		 5dzki-4e3cA:
14.95
5dzkj-4e3cA:
14.95
5dzkx-4e3cA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		4 ILE A  74
GLY A  22
ILE A 101
LEU A  52
 None
 0.82A 5dzki-4ei8A:
1.4
5dzkj-4ei8A:
1.5
5dzkx-4ei8A:
undetectable		 5dzki-4ei8A:
20.62
5dzkj-4ei8A:
20.62
5dzkx-4ei8A:
1.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fa0 GROUP XVI
PHOSPHOLIPASE A1/A2

(Homo sapiens) 		PF04970
(LRAT) 		4 ARG A 121
ILE A  26
GLY A  29
ILE A  92
 None
 0.89A 5dzki-4fa0A:
undetectable
5dzkj-4fa0A:
undetectable
5dzkx-4fa0A:
undetectable		 5dzki-4fa0A:
22.45
5dzkj-4fa0A:
22.45
5dzkx-4fa0A:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4e ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Escherichia
coli) 		PF00227
(Proteasome) 		4 ILE A 105
GLY A  45
ILE A 120
LEU A  95
 None
 0.86A 5dzki-4g4eA:
undetectable
5dzkj-4g4eA:
undetectable
5dzkx-4g4eA:
undetectable		 5dzki-4g4eA:
21.74
5dzkj-4g4eA:
21.74
5dzkx-4g4eA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k46 ADENYLATE KINASE

(Photobacterium
profundum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 ARG A  71
ILE A  72
GLY A  80
ILE A  29
 None
 0.89A 5dzki-4k46A:
undetectable
5dzkj-4k46A:
undetectable
5dzkx-4k46A:
undetectable		 5dzki-4k46A:
22.08
5dzkj-4k46A:
22.08
5dzkx-4k46A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		4 ILE A  13
GLY A 141
ILE A 283
LEU A 153
 None
 0.62A 5dzki-4l6uA:
undetectable
5dzkj-4l6uA:
undetectable
5dzkx-4l6uA:
undetectable		 5dzki-4l6uA:
19.03
5dzkj-4l6uA:
19.03
5dzkx-4l6uA:
0.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg8 PRE-MRNA-PROCESSING
FACTOR 19

(Homo sapiens) 		PF00400
(WD40) 		4 ILE A 459
GLY A 453
ILE A 490
LEU A 452
 None
 0.72A 5dzki-4lg8A:
undetectable
5dzkj-4lg8A:
undetectable
5dzkx-4lg8A:
undetectable		 5dzki-4lg8A:
20.50
5dzkj-4lg8A:
20.50
5dzkx-4lg8A:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		4 ILE A 154
GLY A 151
ILE A 163
LEU A 153
 None
 0.83A 5dzki-4oecA:
undetectable
5dzkj-4oecA:
undetectable
5dzkx-4oecA:
undetectable		 5dzki-4oecA:
19.84
5dzkj-4oecA:
19.84
5dzkx-4oecA:
1.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ILE A 565
GLY A 594
ILE A 485
LEU A 564
 None
 0.82A 5dzki-4pj3A:
undetectable
5dzkj-4pj3A:
undetectable
5dzkx-4pj3A:
undetectable		 5dzki-4pj3A:
8.86
5dzkj-4pj3A:
8.86
5dzkx-4pj3A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qv9 PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 ILE K  12
GLY K  43
ILE K 112
LEU K  42
 None
 0.71A 5dzki-4qv9K:
undetectable
5dzkj-4qv9K:
undetectable
5dzkx-4qv9K:
undetectable		 5dzki-4qv9K:
22.13
5dzkj-4qv9K:
22.13
5dzkx-4qv9K:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s10 GELSOLIN

(Homo sapiens) 		PF00626
(Gelsolin) 		4 ARG C 225
ILE C 197
ILE C 220
LEU C 191
 None
 0.89A 5dzki-4s10C:
undetectable
5dzkj-4s10C:
undetectable
5dzkx-4s10C:
undetectable		 5dzki-4s10C:
20.42
5dzkj-4s10C:
20.42
5dzkx-4s10C:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ttp DEPHOSPHO-COA KINASE

(Legionella
pneumophila) 		PF01121
(CoaE) 		4 ILE A  36
GLY A  12
ILE A 102
LEU A 115
 None
 0.68A 5dzki-4ttpA:
undetectable
5dzkj-4ttpA:
undetectable
5dzkx-4ttpA:
undetectable		 5dzki-4ttpA:
24.29
5dzkj-4ttpA:
24.29
5dzkx-4ttpA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		4 ILE A  85
GLY A   6
ILE A  12
LEU A  52
 None
 0.89A 5dzki-4twbA:
2.1
5dzkj-4twbA:
1.8
5dzkx-4twbA:
undetectable		 5dzki-4twbA:
22.87
5dzkj-4twbA:
22.87
5dzkx-4twbA:
0.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzr PUTATIVE
UNCHARACTERIZED
PROTEIN PH1500

(Pyrococcus
horikoshii) 		PF02933
(CDC48_2) 		4 ILE A 109
GLY A 120
ILE A 146
LEU A 108
 None
 0.87A 5dzki-4uzrA:
undetectable
5dzkj-4uzrA:
undetectable
5dzkx-4uzrA:
undetectable		 5dzki-4uzrA:
20.79
5dzkj-4uzrA:
20.79
5dzkx-4uzrA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wn9 NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 ARG A  21
ILE A  25
GLY A 366
LEU A 440
 None
 0.77A 5dzki-4wn9A:
undetectable
5dzkj-4wn9A:
undetectable
5dzkx-4wn9A:
undetectable		 5dzki-4wn9A:
19.03
5dzkj-4wn9A:
19.03
5dzkx-4wn9A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Streptobacillus
moniliformis) 		PF13407
(Peripla_BP_4) 		4 ILE A 113
GLY A  30
ILE A 289
LEU A  88
 None
 0.84A 5dzki-4z0nA:
undetectable
5dzkj-4z0nA:
undetectable
5dzkx-4z0nA:
undetectable		 5dzki-4z0nA:
20.47
5dzkj-4z0nA:
20.47
5dzkx-4z0nA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis) 		no annotation 4 ILE A 573
GLY A 346
ILE A 556
LEU A 344
 None
FMN  A 900 (-3.4A)
None
None
 0.85A 5dzki-4z38A:
2.6
5dzkj-4z38A:
2.7
5dzkx-4z38A:
undetectable		 5dzki-4z38A:
17.06
5dzkj-4z38A:
17.06
5dzkx-4z38A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 ILE A  34
GLY A  29
ILE A  65
LEU A  33
 None
 0.89A 5dzki-4zm6A:
undetectable
5dzkj-4zm6A:
undetectable
5dzkx-4zm6A:
undetectable		 5dzki-4zm6A:
13.18
5dzkj-4zm6A:
13.18
5dzkx-4zm6A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 ILE A1414
GLY A1308
ILE A1383
LEU A1376
 None
 0.86A 5dzki-5a31A:
undetectable
5dzkj-5a31A:
undetectable
5dzkx-5a31A:
undetectable		 5dzki-5a31A:
8.84
5dzkj-5a31A:
8.84
5dzkx-5a31A:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4b HUMAN
ALPHA-ACTININ-2

(Homo sapiens) 		PF00307
(CH) 		4 ILE A 190
GLY A 183
ILE A 198
LEU A 186
 None
 0.88A 5dzki-5a4bA:
undetectable
5dzkj-5a4bA:
undetectable
5dzkx-5a4bA:
undetectable		 5dzki-5a4bA:
23.40
5dzkj-5a4bA:
23.40
5dzkx-5a4bA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 ILE M 243
GLY M 234
ILE M 208
LEU M 241
 None
 0.82A 5dzki-5a5tM:
undetectable
5dzkj-5a5tM:
undetectable
5dzkx-5a5tM:
undetectable		 5dzki-5a5tM:
21.97
5dzkj-5a5tM:
21.97
5dzkx-5a5tM:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d95 AMINOTRANSFERASE
CLASS-III

(Sphaerobacter
thermophilus) 		PF00202
(Aminotran_3) 		4 ILE A 209
GLY A 204
ILE A 244
LEU A 208
 None
 0.88A 5dzki-5d95A:
undetectable
5dzkj-5d95A:
undetectable
5dzkx-5d95A:
undetectable		 5dzki-5d95A:
17.71
5dzkj-5d95A:
17.71
5dzkx-5d95A:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5faf GELSOLIN

(Homo sapiens) 		PF00626
(Gelsolin) 		4 ARG A 225
ILE A 197
ILE A 220
LEU A 191
 None
None
GOL  A 302 (-4.3A)
None
 0.76A 5dzki-5fafA:
undetectable
5dzkj-5fafA:
undetectable
5dzkx-5fafA:
undetectable		 5dzki-5fafA:
19.80
5dzkj-5fafA:
19.80
5dzkx-5fafA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ILE C 122
GLY C  88
ILE C 451
LEU C  70
 None
 0.85A 5dzki-5fseC:
undetectable
5dzkj-5fseC:
2.2
5dzkx-5fseC:
undetectable		 5dzki-5fseC:
15.72
5dzkj-5fseC:
15.72
5dzkx-5fseC:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fws KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 ILE A 252
GLY A 273
ILE A 244
LEU A 296
 None
 0.86A 5dzki-5fwsA:
undetectable
5dzkj-5fwsA:
undetectable
5dzkx-5fwsA:
undetectable		 5dzki-5fwsA:
19.36
5dzkj-5fwsA:
19.36
5dzkx-5fwsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzo PROBABLE JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION PROT
EIN 2C

(Homo sapiens) 		PF02373
(JmjC) 		4 ARG A2403
ILE A2402
GLY A2396
ILE A2424
 None
 0.87A 5dzki-5fzoA:
undetectable
5dzkj-5fzoA:
undetectable
5dzkx-5fzoA:
undetectable		 5dzki-5fzoA:
20.67
5dzkj-5fzoA:
20.67
5dzkx-5fzoA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 4 ILE A 103
GLY A 216
ILE A 168
LEU A 161
 None
 0.75A 5dzki-5gqfA:
undetectable
5dzkj-5gqfA:
undetectable
5dzkx-5gqfA:
undetectable		 5dzki-5gqfA:
14.08
5dzkj-5gqfA:
14.08
5dzkx-5gqfA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 ILE A 103
GLY A 125
ILE A  75
LEU A  40
 None
 0.82A 5dzki-5jodA:
undetectable
5dzkj-5jodA:
undetectable
5dzkx-5jodA:
undetectable		 5dzki-5jodA:
20.11
5dzkj-5jodA:
20.11
5dzkx-5jodA:
0.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 ILE S 198
GLY S  58
ILE S 190
LEU S 169
 None
 0.78A 5dzki-5k0yS:
undetectable
5dzkj-5k0yS:
undetectable
5dzkx-5k0yS:
undetectable		 5dzki-5k0yS:
19.26
5dzkj-5k0yS:
19.26
5dzkx-5k0yS:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB) 		4 ILE A 435
GLY A 413
ILE A 264
LEU A 290
 None
 0.80A 5dzki-5kwaA:
3.0
5dzkj-5kwaA:
3.0
5dzkx-5kwaA:
undetectable		 5dzki-5kwaA:
19.05
5dzkj-5kwaA:
19.05
5dzkx-5kwaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly6 PNEUMOLYSIN

(Streptococcus
pneumoniae) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 ILE B 329
GLY B 326
ILE B 198
LEU B 327
 None
 0.73A 5dzki-5ly6B:
undetectable
5dzkj-5ly6B:
undetectable
5dzkx-5ly6B:
undetectable		 5dzki-5ly6B:
17.83
5dzkj-5ly6B:
17.83
5dzkx-5ly6B:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2

(Porphyromonas
gingivalis) 		no annotation 4 ILE B 281
GLY B 270
ILE B 312
LEU B 273
 None
 0.83A 5dzki-5nfiB:
undetectable
5dzkj-5nfiB:
undetectable
5dzkx-5nfiB:
undetectable		 5dzki-5nfiB:
undetectable
5dzkj-5nfiB:
undetectable
5dzkx-5nfiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ARG A 365
ILE A 403
GLY A 379
ILE A 367
 None
 0.85A 5dzki-5oljA:
undetectable
5dzkj-5oljA:
undetectable
5dzkx-5oljA:
undetectable		 5dzki-5oljA:
14.05
5dzkj-5oljA:
14.05
5dzkx-5oljA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S11,
PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 ARG X  87
ILE X  85
GLY X  56
ILE X 139
 None
 0.73A 5dzki-5optX:
undetectable
5dzkj-5optX:
undetectable
5dzkx-5optX:
undetectable		 5dzki-5optX:
20.59
5dzkj-5optX:
20.59
5dzkx-5optX:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Schizosaccharomyces
pombe) 		PF01487
(DHquinase_I)
PF08501
(Shikimate_dh_N) 		4 ILE C1430
GLY C1417
ILE C1464
LEU C1433
 None
 0.89A 5dzki-5swvC:
1.7
5dzkj-5swvC:
1.7
5dzkx-5swvC:
undetectable		 5dzki-5swvC:
17.84
5dzkj-5swvC:
17.84
5dzkx-5swvC:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		4 ILE A 158
GLY A 182
ILE A 169
LEU A 122
 None
B12  A 802 (-3.4A)
None
None
 0.86A 5dzki-5ul4A:
undetectable
5dzkj-5ul4A:
undetectable
5dzkx-5ul4A:
undetectable		 5dzki-5ul4A:
13.31
5dzkj-5ul4A:
13.31
5dzkx-5ul4A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vto BLASTICIDIN M

(Streptomyces
griseochromogenes) 		no annotation 4 ILE A 106
GLY A 134
ILE A 116
LEU A 131
 None
 0.87A 5dzki-5vtoA:
undetectable
5dzkj-5vtoA:
undetectable
5dzkx-5vtoA:
undetectable		 5dzki-5vtoA:
undetectable
5dzkj-5vtoA:
undetectable
5dzkx-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1

(Homo sapiens) 		no annotation 4 ILE B 131
GLY B 114
ILE B  51
LEU B 115
 None
 0.87A 5dzki-5wy8B:
undetectable
5dzkj-5wy8B:
undetectable
5dzkx-5wy8B:
undetectable		 5dzki-5wy8B:
undetectable
5dzkj-5wy8B:
undetectable
5dzkx-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 4 ILE C 245
GLY C 429
ILE C 433
LEU C 407
 None
 0.85A 5dzki-5x6xC:
undetectable
5dzkj-5x6xC:
undetectable
5dzkx-5x6xC:
undetectable		 5dzki-5x6xC:
undetectable
5dzkj-5x6xC:
undetectable
5dzkx-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 4 ILE A 438
GLY A 433
ILE A 450
LEU A 437
 None
 0.88A 5dzki-5yl7A:
undetectable
5dzkj-5yl7A:
undetectable
5dzkx-5yl7A:
undetectable		 5dzki-5yl7A:
undetectable
5dzkj-5yl7A:
undetectable
5dzkx-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zm4 DIOXYGENASE ANDA

(Aspergillus
stellatus) 		no annotation 4 ARG A  13
ILE A  11
GLY A 172
ILE A  34
 None
 0.82A 5dzki-5zm4A:
undetectable
5dzkj-5zm4A:
undetectable
5dzkx-5zm4A:
undetectable		 5dzki-5zm4A:
undetectable
5dzkj-5zm4A:
undetectable
5dzkx-5zm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ILE A 445
GLY A 368
ILE A 376
LEU A 367
 None
 0.82A 5dzki-5zqzA:
8.4
5dzkj-5zqzA:
8.4
5dzkx-5zqzA:
undetectable		 5dzki-5zqzA:
undetectable
5dzkj-5zqzA:
undetectable
5dzkx-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6d -

(-) 		no annotation 4 ILE A  86
GLY A 113
ILE A  92
LEU A 114
 None
 0.81A 5dzki-6d6dA:
undetectable
5dzkj-6d6dA:
undetectable
5dzkx-6d6dA:
undetectable		 5dzki-6d6dA:
undetectable
5dzkj-6d6dA:
undetectable
5dzkx-6d6dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 ILE A 257
GLY A 250
ILE A 304
LEU A 254
 None
 0.82A 5dzki-6eu6A:
undetectable
5dzkj-6eu6A:
undetectable
5dzkx-6eu6A:
undetectable		 5dzki-6eu6A:
undetectable
5dzkj-6eu6A:
undetectable
5dzkx-6eu6A:
undetectable