SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_W_BEZW801_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermococcus
litoralis) 		PF01470
(Peptidase_C15) 		4 ILE A  66
GLY A  39
ILE A 198
LEU A   5
 None
 0.81A 5dzkB-1a2zA:
0.0
5dzkI-1a2zA:
0.0
5dzkW-1a2zA:
undetectable		 5dzkB-1a2zA:
22.78
5dzkI-1a2zA:
21.40
5dzkW-1a2zA:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus) 		PF00079
(Serpin) 		4 PHE A 176
GLY A 149
ILE A 208
LEU A 214
 None
 0.84A 5dzkB-1attA:
undetectable
5dzkI-1attA:
0.0
5dzkW-1attA:
undetectable		 5dzkB-1attA:
17.51
5dzkI-1attA:
19.91
5dzkW-1attA:
0.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu2 CYCLIN HOMOLOG

(Saimiriine
gammaherpesvirus
2) 		PF00134
(Cyclin_N)
PF09241
(Herp-Cyclin) 		4 ILE A  79
GLY A  98
ILE A 104
LEU A  80
 None
 0.85A 5dzkB-1bu2A:
undetectable
5dzkI-1bu2A:
undetectable
5dzkW-1bu2A:
undetectable		 5dzkB-1bu2A:
20.39
5dzkI-1bu2A:
23.27
5dzkW-1bu2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2i PROTEIN (RESTRICTION
ENDONUCLEASE BGLII)

(Bacillus
subtilis) 		PF09195
(Endonuc-BglII) 		4 ILE A 128
GLY A  86
ILE A  23
LEU A  91
 None
 0.72A 5dzkB-1d2iA:
0.9
5dzkI-1d2iA:
undetectable
5dzkW-1d2iA:
undetectable		 5dzkB-1d2iA:
22.83
5dzkI-1d2iA:
24.39
5dzkW-1d2iA:
1.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 ILE A  47
GLY A  72
ILE A 130
LEU A  46
 None
 0.86A 5dzkB-1ddkA:
undetectable
5dzkI-1ddkA:
undetectable
5dzkW-1ddkA:
undetectable		 5dzkB-1ddkA:
22.41
5dzkI-1ddkA:
23.17
5dzkW-1ddkA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus gallus) 		PF00644
(PARP)
PF02877
(PARP_reg) 		4 PHE A 897
GLY A 922
ILE A 895
LEU A 920
 None
 0.85A 5dzkB-1efyA:
undetectable
5dzkI-1efyA:
undetectable
5dzkW-1efyA:
undetectable		 5dzkB-1efyA:
21.43
5dzkI-1efyA:
18.97
5dzkW-1efyA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		4 ILE A 281
GLY A 307
ILE A 292
LEU A 393
 None
 0.85A 5dzkB-1f0xA:
undetectable
5dzkI-1f0xA:
0.0
5dzkW-1f0xA:
undetectable		 5dzkB-1f0xA:
15.26
5dzkI-1f0xA:
16.64
5dzkW-1f0xA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ILE A 390
GLY A 311
ILE A 319
LEU A 310
 None
ATP  A 601 (-3.5A)
None
ATP  A 601 (-4.9A)
 0.86A 5dzkB-1gz4A:
undetectable
5dzkI-1gz4A:
1.1
5dzkW-1gz4A:
undetectable		 5dzkB-1gz4A:
17.30
5dzkI-1gz4A:
16.64
5dzkW-1gz4A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		4 ILE A 233
GLY A 224
ILE A 244
LEU A 236
 None
 0.84A 5dzkB-1i2oA:
2.4
5dzkI-1i2oA:
0.0
5dzkW-1i2oA:
undetectable		 5dzkB-1i2oA:
22.88
5dzkI-1i2oA:
21.38
5dzkW-1i2oA:
0.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		4 PHE C 312
ILE C 557
ILE C 307
LEU C 560
 None
 0.82A 5dzkB-1j3jC:
undetectable
5dzkI-1j3jC:
undetectable
5dzkW-1j3jC:
undetectable		 5dzkB-1j3jC:
21.10
5dzkI-1j3jC:
19.94
5dzkW-1j3jC:
2.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 PHE A 100
ILE A  67
GLY A  99
ILE A  85
LEU A  64
 None
 1.41A 5dzkB-1kkhA:
undetectable
5dzkI-1kkhA:
undetectable
5dzkW-1kkhA:
undetectable		 5dzkB-1kkhA:
19.09
5dzkI-1kkhA:
22.33
5dzkW-1kkhA:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 PHE A  67
ILE A 135
GLY A  81
ILE A 148
 None
 0.82A 5dzkB-1l1fA:
undetectable
5dzkI-1l1fA:
undetectable
5dzkW-1l1fA:
undetectable		 5dzkB-1l1fA:
19.51
5dzkI-1l1fA:
19.56
5dzkW-1l1fA:
0.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 ILE A 368
GLY A  52
ILE A  60
LEU A  48
 FAD  A2457 (-3.7A)
FAD  A2457 (-3.0A)
FAD  A2457 ( 3.5A)
FAD  A2457 (-2.9A)
 0.74A 5dzkB-1lqtA:
undetectable
5dzkI-1lqtA:
undetectable
5dzkW-1lqtA:
undetectable		 5dzkB-1lqtA:
19.65
5dzkI-1lqtA:
19.09
5dzkW-1lqtA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m93 SERINE PROTEINASE
INHIBITOR 2
SERINE PROTEINASE
INHIBITOR 2

(Cowpox virus;
Cowpox virus) 		PF00079
(Serpin)
PF00079
(Serpin) 		5 PHE B  77
ILE A  29
GLY A  33
ILE B  81
LEU A  30
 None
 1.49A 5dzkB-1m93B:
undetectable
5dzkI-1m93B:
undetectable
5dzkW-1m93B:
undetectable		 5dzkB-1m93B:
23.32
5dzkI-1m93B:
22.57
5dzkW-1m93B:
0.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 ILE A 103
GLY A 125
ILE A  75
LEU A  40
 None
 0.79A 5dzkB-1miqA:
undetectable
5dzkI-1miqA:
undetectable
5dzkW-1miqA:
undetectable		 5dzkB-1miqA:
18.98
5dzkI-1miqA:
19.52
5dzkW-1miqA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A  67
GLY A 107
ILE A  94
LEU A  66
 ANP  A1285 ( 4.9A)
ANP  A1285 (-3.2A)
None
ANP  A1285 (-4.0A)
 0.80A 5dzkB-1oj4A:
undetectable
5dzkI-1oj4A:
undetectable
5dzkW-1oj4A:
undetectable		 5dzkB-1oj4A:
22.03
5dzkI-1oj4A:
21.23
5dzkW-1oj4A:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pku NUCLEOSIDE
DIPHOSPHATE KINASE I

(Oryza sativa) 		PF00334
(NDK) 		4 PHE A  28
ILE A 104
GLY A  87
ILE A  24
 None
 0.81A 5dzkB-1pkuA:
undetectable
5dzkI-1pkuA:
undetectable
5dzkW-1pkuA:
undetectable		 5dzkB-1pkuA:
21.80
5dzkI-1pkuA:
22.49
5dzkW-1pkuA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea) 		PF01338
(Bac_thur_toxin) 		4 ILE A 103
GLY A  76
ILE A  82
LEU A 104
 None
 0.79A 5dzkB-1pp0A:
undetectable
5dzkI-1pp0A:
undetectable
5dzkW-1pp0A:
undetectable		 5dzkB-1pp0A:
21.21
5dzkI-1pp0A:
19.63
5dzkW-1pp0A:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlv TRANSCRIPTION
ANTITERMINATOR LICT

(Bacillus
subtilis) 		PF00874
(PRD) 		4 ILE A 160
GLY A 154
ILE A 132
LEU A 158
 None
 0.86A 5dzkB-1tlvA:
undetectable
5dzkI-1tlvA:
undetectable
5dzkW-1tlvA:
undetectable		 5dzkB-1tlvA:
20.59
5dzkI-1tlvA:
23.14
5dzkW-1tlvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		4 PHE A  27
ILE A 315
GLY A 363
ILE A 283
 None
 0.78A 5dzkB-1to6A:
2.1
5dzkI-1to6A:
undetectable
5dzkW-1to6A:
undetectable		 5dzkB-1to6A:
19.30
5dzkI-1to6A:
19.57
5dzkW-1to6A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucv EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF00536
(SAM_1) 		4 ILE A  50
GLY A  54
ILE A  59
LEU A  52
 None
 0.80A 5dzkB-1ucvA:
undetectable
5dzkI-1ucvA:
undetectable
5dzkW-1ucvA:
undetectable		 5dzkB-1ucvA:
15.81
5dzkI-1ucvA:
21.74
5dzkW-1ucvA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE

(Bacillus
subtilis) 		PF00480
(ROK) 		4 PHE A 175
ILE A 128
GLY A 152
ILE A 209
 None
 0.82A 5dzkB-1xc3A:
undetectable
5dzkI-1xc3A:
undetectable
5dzkW-1xc3A:
undetectable		 5dzkB-1xc3A:
21.00
5dzkI-1xc3A:
20.79
5dzkW-1xc3A:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiq NUCLEOSIDE
DIPHOSPHATE KINASE B

(Plasmodium
falciparum) 		PF00334
(NDK) 		4 PHE A  25
ILE A 101
GLY A  84
ILE A  21
 None
 0.82A 5dzkB-1xiqA:
undetectable
5dzkI-1xiqA:
undetectable
5dzkW-1xiqA:
undetectable		 5dzkB-1xiqA:
19.91
5dzkI-1xiqA:
19.40
5dzkW-1xiqA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PHE A 300
ILE A  68
GLY A 336
ILE A 379
 None
 0.55A 5dzkB-1ysjA:
undetectable
5dzkI-1ysjA:
undetectable
5dzkW-1ysjA:
undetectable		 5dzkB-1ysjA:
20.79
5dzkI-1ysjA:
21.99
5dzkW-1ysjA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 PHE B 375
ILE B 443
GLY B 371
ILE B 469
 None
 0.83A 5dzkB-2afhB:
undetectable
5dzkI-2afhB:
undetectable
5dzkW-2afhB:
undetectable		 5dzkB-2afhB:
16.70
5dzkI-2afhB:
16.54
5dzkW-2afhB:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arf WILSON DISEASE
ATPASE

(Homo sapiens) 		PF00702
(Hydrolase) 		4 ILE A1194
GLY A1072
ILE A1180
LEU A1071
 None
 0.84A 5dzkB-2arfA:
undetectable
5dzkI-2arfA:
undetectable
5dzkW-2arfA:
undetectable		 5dzkB-2arfA:
25.00
5dzkI-2arfA:
22.22
5dzkW-2arfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		4 PHE I 175
GLY I 148
ILE I 207
LEU I 213
 None
 0.85A 5dzkB-2b4xI:
undetectable
5dzkI-2b4xI:
undetectable
5dzkW-2b4xI:
undetectable		 5dzkB-2b4xI:
19.90
5dzkI-2b4xI:
18.03
5dzkW-2b4xI:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1d TRANSALDOLASE

(Mus musculus) 		PF00923
(TAL_FSA) 		4 ILE A 244
GLY A 235
ILE A 255
LEU A 247
 None
 0.85A 5dzkB-2e1dA:
2.3
5dzkI-2e1dA:
undetectable
5dzkW-2e1dA:
undetectable		 5dzkB-2e1dA:
21.25
5dzkI-2e1dA:
20.59
5dzkW-2e1dA:
0.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2c PUTATIVE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN

(Corynebacterium
diphtheriae) 		PF00994
(MoCF_biosynth) 		4 ILE A  70
GLY A 122
ILE A  59
LEU A 132
 None
 0.82A 5dzkB-2g2cA:
2.3
5dzkI-2g2cA:
undetectable
5dzkW-2g2cA:
undetectable		 5dzkB-2g2cA:
23.32
5dzkI-2g2cA:
24.39
5dzkW-2g2cA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		4 ILE A 171
GLY A 206
ILE A 151
LEU A 205
 None
 0.85A 5dzkB-2g8lA:
undetectable
5dzkI-2g8lA:
undetectable
5dzkW-2g8lA:
undetectable		 5dzkB-2g8lA:
21.78
5dzkI-2g8lA:
18.60
5dzkW-2g8lA:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		4 ILE A  62
GLY A  11
ILE A  88
LEU A  38
 None
 0.66A 5dzkB-2i5bA:
3.1
5dzkI-2i5bA:
undetectable
5dzkW-2i5bA:
undetectable		 5dzkB-2i5bA:
23.16
5dzkI-2i5bA:
21.69
5dzkW-2i5bA:
1.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icg LIN2918 PROTEIN

(Listeria
innocua) 		PF14568
(SUKH_6) 		4 ILE A  99
GLY A 144
ILE A 110
LEU A 147
 None
 0.75A 5dzkB-2icgA:
undetectable
5dzkI-2icgA:
undetectable
5dzkW-2icgA:
undetectable		 5dzkB-2icgA:
24.89
5dzkI-2icgA:
21.29
5dzkW-2icgA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		4 PHE A  80
ILE A  40
GLY A  57
ILE A  67
 None
 0.87A 5dzkB-2jg5A:
undetectable
5dzkI-2jg5A:
undetectable
5dzkW-2jg5A:
undetectable		 5dzkB-2jg5A:
22.22
5dzkI-2jg5A:
19.61
5dzkW-2jg5A:
0.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 ILE A 113
GLY A   6
ILE A 115
LEU A  87
 None
 0.87A 5dzkB-2jjmA:
4.4
5dzkI-2jjmA:
3.3
5dzkW-2jjmA:
undetectable		 5dzkB-2jjmA:
20.55
5dzkI-2jjmA:
19.90
5dzkW-2jjmA:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nan CD302 ANTIGEN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 ILE A  89
GLY A  92
ILE A  75
LEU A  90
 None
 0.82A 5dzkB-2nanA:
undetectable
5dzkI-2nanA:
undetectable
5dzkW-2nanA:
undetectable		 5dzkB-2nanA:
20.95
5dzkI-2nanA:
21.03
5dzkW-2nanA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 348
GLY A 104
ILE A 499
LEU A 107
 None
 0.76A 5dzkB-2nz9A:
undetectable
5dzkI-2nz9A:
undetectable
5dzkW-2nz9A:
undetectable		 5dzkB-2nz9A:
10.73
5dzkI-2nz9A:
8.76
5dzkW-2nz9A:
0.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		4 PHE A  23
ILE A  62
GLY A 233
ILE A  37
 None
 0.81A 5dzkB-2pfzA:
undetectable
5dzkI-2pfzA:
undetectable
5dzkW-2pfzA:
undetectable		 5dzkB-2pfzA:
20.82
5dzkI-2pfzA:
21.04
5dzkW-2pfzA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		4 ILE A 223
GLY A 139
ILE A 180
LEU A 193
 None
 0.58A 5dzkB-2qvlA:
undetectable
5dzkI-2qvlA:
undetectable
5dzkW-2qvlA:
undetectable		 5dzkB-2qvlA:
21.53
5dzkI-2qvlA:
21.41
5dzkW-2qvlA:
0.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		4 ILE A 293
GLY A 308
ILE A  56
LEU A 309
 None
 0.85A 5dzkB-2rinA:
undetectable
5dzkI-2rinA:
undetectable
5dzkW-2rinA:
undetectable		 5dzkB-2rinA:
19.93
5dzkI-2rinA:
20.21
5dzkW-2rinA:
0.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 PHE A 498
ILE A 754
GLY A 494
ILE A 749
 None
 0.82A 5dzkB-2vdcA:
1.9
5dzkI-2vdcA:
undetectable
5dzkW-2vdcA:
undetectable		 5dzkB-2vdcA:
9.76
5dzkI-2vdcA:
8.34
5dzkW-2vdcA:
0.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ILE A1200
GLY A1195
ILE A1466
LEU A1199
 None
 0.79A 5dzkB-2xkkA:
undetectable
5dzkI-2xkkA:
undetectable
5dzkW-2xkkA:
undetectable		 5dzkB-2xkkA:
17.06
5dzkI-2xkkA:
14.91
5dzkW-2xkkA:
1.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
synthetic
construct) 		PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		4 ILE C 348
GLY C 416
ILE C 412
LEU C 350
 None
None
None
GSU  C1001 (-3.8A)
 0.80A 5dzkB-3al0C:
undetectable
5dzkI-3al0C:
undetectable
5dzkW-3al0C:
undetectable		 5dzkB-3al0C:
18.89
5dzkI-3al0C:
15.62
5dzkW-3al0C:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		4 ILE A 244
GLY A 222
ILE A 235
LEU A 243
 None
 0.83A 5dzkB-3anyA:
1.6
5dzkI-3anyA:
undetectable
5dzkW-3anyA:
undetectable		 5dzkB-3anyA:
19.69
5dzkI-3anyA:
19.02
5dzkW-3anyA:
0.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ILE A 180
GLY A 124
ILE A 132
LEU A 123
 None
 0.86A 5dzkB-3dooA:
2.6
5dzkI-3dooA:
undetectable
5dzkW-3dooA:
undetectable		 5dzkB-3dooA:
22.34
5dzkI-3dooA:
22.26
5dzkW-3dooA:
0.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 PHE A 125
ILE A 178
GLY A 304
ILE A 175
LEU A 306
 None
 1.19A 5dzkB-3ec7A:
undetectable
5dzkI-3ec7A:
1.5
5dzkW-3ec7A:
undetectable		 5dzkB-3ec7A:
21.30
5dzkI-3ec7A:
20.55
5dzkW-3ec7A:
0.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 ILE A 502
GLY A 592
ILE A 526
LEU A 554
 None
 0.74A 5dzkB-3eqnA:
undetectable
5dzkI-3eqnA:
undetectable
5dzkW-3eqnA:
undetectable		 5dzkB-3eqnA:
13.53
5dzkI-3eqnA:
13.33
5dzkW-3eqnA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 PHE A 336
ILE A 281
GLY A 297
ILE A 285
 None
 0.82A 5dzkB-3gdeA:
undetectable
5dzkI-3gdeA:
undetectable
5dzkW-3gdeA:
undetectable		 5dzkB-3gdeA:
16.73
5dzkI-3gdeA:
16.67
5dzkW-3gdeA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 ILE A 111
GLY A 108
ILE A 101
LEU A 110
 None
 0.83A 5dzkB-3h0lA:
undetectable
5dzkI-3h0lA:
undetectable
5dzkW-3h0lA:
undetectable		 5dzkB-3h0lA:
19.70
5dzkI-3h0lA:
17.44
5dzkW-3h0lA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		4 ILE A  70
GLY A 228
ILE A   9
LEU A 226
 None
 0.86A 5dzkB-3h6eA:
undetectable
5dzkI-3h6eA:
undetectable
5dzkW-3h6eA:
undetectable		 5dzkB-3h6eA:
18.99
5dzkI-3h6eA:
18.57
5dzkW-3h6eA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfi PUTATIVE REGULATOR

(Escherichia
coli) 		PF07702
(UTRA) 		4 ILE A  95
GLY A  80
ILE A  73
LEU A  98
 None
 0.86A 5dzkB-3hfiA:
undetectable
5dzkI-3hfiA:
undetectable
5dzkW-3hfiA:
undetectable		 5dzkB-3hfiA:
22.12
5dzkI-3hfiA:
24.42
5dzkW-3hfiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		4 ILE A 463
GLY A 478
ILE A 466
LEU A 481
 None
FMN  A1002 (-3.7A)
None
FMN  A1002 ( 4.9A)
 0.81A 5dzkB-3i6rA:
undetectable
5dzkI-3i6rA:
undetectable
5dzkW-3i6rA:
undetectable		 5dzkB-3i6rA:
18.34
5dzkI-3i6rA:
18.45
5dzkW-3i6rA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igx TRANSALDOLASE

(Francisella
tularensis) 		PF00923
(TAL_FSA) 		4 ILE A  92
GLY A  85
ILE A  25
LEU A  89
 None
 0.85A 5dzkB-3igxA:
2.2
5dzkI-3igxA:
undetectable
5dzkW-3igxA:
undetectable		 5dzkB-3igxA:
21.61
5dzkI-3igxA:
21.17
5dzkW-3igxA:
0.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ILE A 345
GLY A  49
ILE A 389
LEU A  52
 None
 0.78A 5dzkB-3lk6A:
undetectable
5dzkI-3lk6A:
undetectable
5dzkW-3lk6A:
undetectable		 5dzkB-3lk6A:
16.40
5dzkI-3lk6A:
16.31
5dzkW-3lk6A:
0.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw4 NEUREXIN-2-BETA

(Mus musculus) 		PF02210
(Laminin_G_2) 		4 PHE A  87
ILE A 249
GLY A 214
LEU A  93
 None
 0.80A 5dzkB-3mw4A:
undetectable
5dzkI-3mw4A:
undetectable
5dzkW-3mw4A:
undetectable		 5dzkB-3mw4A:
20.52
5dzkI-3mw4A:
23.08
5dzkW-3mw4A:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of5 DETHIOBIOTIN
SYNTHETASE

(Francisella
tularensis) 		PF13500
(AAA_26) 		4 ILE A 172
GLY A   8
ILE A  18
LEU A 142
 None
 0.70A 5dzkB-3of5A:
undetectable
5dzkI-3of5A:
undetectable
5dzkW-3of5A:
undetectable		 5dzkB-3of5A:
20.51
5dzkI-3of5A:
20.75
5dzkW-3of5A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION

(Bifidobacterium
adolescentis) 		PF13556
(HTH_30) 		5 PHE A 115
ILE A  85
GLY A  57
ILE A  71
LEU A  93
 None
 1.07A 5dzkB-3onqA:
undetectable
5dzkI-3onqA:
undetectable
5dzkW-3onqA:
undetectable		 5dzkB-3onqA:
23.28
5dzkI-3onqA:
22.94
5dzkW-3onqA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 PHE A 701
ILE A 727
GLY A 700
ILE A 749
LEU A 710
 None
 1.46A 5dzkB-3sunA:
undetectable
5dzkI-3sunA:
undetectable
5dzkW-3sunA:
undetectable		 5dzkB-3sunA:
13.39
5dzkI-3sunA:
13.16
5dzkW-3sunA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 ILE A 680
GLY A 849
ILE A 670
LEU A 678
 None
 0.87A 5dzkB-3tsyA:
undetectable
5dzkI-3tsyA:
undetectable
5dzkW-3tsyA:
undetectable		 5dzkB-3tsyA:
12.95
5dzkI-3tsyA:
13.31
5dzkW-3tsyA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS

(Pyrococcus
furiosus) 		PF08489
(DUF1743) 		4 ILE A  64
GLY A 100
ILE A  69
LEU A   2
 None
 0.76A 5dzkB-3u02A:
undetectable
5dzkI-3u02A:
undetectable
5dzkW-3u02A:
undetectable		 5dzkB-3u02A:
21.84
5dzkI-3u02A:
21.69
5dzkW-3u02A:
1.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4g ARGININE REPRESSOR

(Vibrio
vulnificus) 		PF01316
(Arg_repressor)
PF02863
(Arg_repressor_C) 		4 ILE A 108
GLY A 101
ILE A 131
LEU A  85
 None
 0.83A 5dzkB-3v4gA:
undetectable
5dzkI-3v4gA:
undetectable
5dzkW-3v4gA:
undetectable		 5dzkB-3v4gA:
22.51
5dzkI-3v4gA:
19.81
5dzkW-3v4gA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 ILE L  12
GLY L  43
ILE L 112
LEU L  42
 None
 0.75A 5dzkB-3wxrL:
undetectable
5dzkI-3wxrL:
undetectable
5dzkW-3wxrL:
undetectable		 5dzkB-3wxrL:
22.96
5dzkI-3wxrL:
20.20
5dzkW-3wxrL:
1.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn7 COPPER INDUCED
NITROREDUCTASE D

(Lactococcus
lactis) 		PF00881
(Nitroreductase) 		5 PHE A 179
ILE A  50
GLY A  97
ILE A  30
LEU A  51
 None
 1.49A 5dzkB-4bn7A:
undetectable
5dzkI-4bn7A:
undetectable
5dzkW-4bn7A:
undetectable		 5dzkB-4bn7A:
22.27
5dzkI-4bn7A:
24.00
5dzkW-4bn7A:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PHE A 408
ILE A 250
GLY A 294
ILE A 412
 None
 0.81A 5dzkB-4c23A:
undetectable
5dzkI-4c23A:
undetectable
5dzkW-4c23A:
undetectable		 5dzkB-4c23A:
18.49
5dzkI-4c23A:
18.75
5dzkW-4c23A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f36 NUCLEOSIDE
DIPHOSPHATE KINASE

(Trypanosoma
brucei) 		PF00334
(NDK) 		4 PHE A  27
ILE A 103
GLY A  86
ILE A  23
 None
 0.78A 5dzkB-4f36A:
undetectable
5dzkI-4f36A:
undetectable
5dzkW-4f36A:
undetectable		 5dzkB-4f36A:
22.27
5dzkI-4f36A:
23.59
5dzkW-4f36A:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2) 		4 PHE E  29
ILE E  48
GLY E  62
ILE E  10
 None
 0.84A 5dzkB-4f52E:
undetectable
5dzkI-4f52E:
1.9
5dzkW-4f52E:
undetectable		 5dzkB-4f52E:
17.53
5dzkI-4f52E:
17.94
5dzkW-4f52E:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4e ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Escherichia
coli) 		PF00227
(Proteasome) 		4 ILE A 105
GLY A  45
ILE A 120
LEU A  95
 None
 0.87A 5dzkB-4g4eA:
undetectable
5dzkI-4g4eA:
undetectable
5dzkW-4g4eA:
undetectable		 5dzkB-4g4eA:
22.59
5dzkI-4g4eA:
21.74
5dzkW-4g4eA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00245
(Alk_phosphatase) 		5 PHE A 334
ILE A 354
GLY A 312
ILE A 338
LEU A  40
 None
 1.50A 5dzkB-4kjdA:
undetectable
5dzkI-4kjdA:
undetectable
5dzkW-4kjdA:
undetectable		 5dzkB-4kjdA:
18.31
5dzkI-4kjdA:
17.12
5dzkW-4kjdA:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		4 ILE A  13
GLY A 141
ILE A 283
LEU A 153
 None
 0.65A 5dzkB-4l6uA:
undetectable
5dzkI-4l6uA:
undetectable
5dzkW-4l6uA:
undetectable		 5dzkB-4l6uA:
19.88
5dzkI-4l6uA:
19.03
5dzkW-4l6uA:
0.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg8 PRE-MRNA-PROCESSING
FACTOR 19

(Homo sapiens) 		PF00400
(WD40) 		4 ILE A 459
GLY A 453
ILE A 490
LEU A 452
 None
 0.66A 5dzkB-4lg8A:
undetectable
5dzkI-4lg8A:
undetectable
5dzkW-4lg8A:
undetectable		 5dzkB-4lg8A:
21.11
5dzkI-4lg8A:
20.50
5dzkW-4lg8A:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr4 HYPOTHETICAL PROTEIN

([Eubacterium]
rectale) 		no annotation 4 PHE A 228
ILE A 164
GLY A 242
ILE A 226
 None
 0.86A 5dzkB-4lr4A:
undetectable
5dzkI-4lr4A:
undetectable
5dzkW-4lr4A:
undetectable		 5dzkB-4lr4A:
20.28
5dzkI-4lr4A:
19.58
5dzkW-4lr4A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1j CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		4 ILE A  96
GLY A 159
ILE A 169
LEU A  98
 None
 0.84A 5dzkB-4o1jA:
undetectable
5dzkI-4o1jA:
undetectable
5dzkW-4o1jA:
undetectable		 5dzkB-4o1jA:
22.76
5dzkI-4o1jA:
25.47
5dzkW-4o1jA:
1.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		4 ILE A 154
GLY A 151
ILE A 163
LEU A 153
 None
 0.84A 5dzkB-4oecA:
3.2
5dzkI-4oecA:
1.5
5dzkW-4oecA:
undetectable		 5dzkB-4oecA:
21.11
5dzkI-4oecA:
19.84
5dzkW-4oecA:
1.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Mesorhizobium
japonicum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ILE A 101
GLY A  74
ILE A   8
LEU A 104
 None
None
NAD  A 402 (-4.6A)
None
 0.87A 5dzkB-4om8A:
2.2
5dzkI-4om8A:
undetectable
5dzkW-4om8A:
undetectable		 5dzkB-4om8A:
23.45
5dzkI-4om8A:
20.19
5dzkW-4om8A:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ILE A 565
GLY A 594
ILE A 485
LEU A 564
 None
 0.77A 5dzkB-4pj3A:
undetectable
5dzkI-4pj3A:
undetectable
5dzkW-4pj3A:
undetectable		 5dzkB-4pj3A:
9.86
5dzkI-4pj3A:
8.86
5dzkW-4pj3A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3n MGS-M5

(unidentified) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A  77
GLY A 143
ILE A 100
LEU A 117
 None
 0.74A 5dzkB-4q3nA:
undetectable
5dzkI-4q3nA:
undetectable
5dzkW-4q3nA:
undetectable		 5dzkB-4q3nA:
22.63
5dzkI-4q3nA:
21.91
5dzkW-4q3nA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qv9 PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 ILE K  12
GLY K  43
ILE K 112
LEU K  42
 None
 0.72A 5dzkB-4qv9K:
undetectable
5dzkI-4qv9K:
undetectable
5dzkW-4qv9K:
undetectable		 5dzkB-4qv9K:
22.40
5dzkI-4qv9K:
22.13
5dzkW-4qv9K:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A  17
ILE A  42
GLY A  57
ILE A  45
 None
 0.84A 5dzkB-4r5cA:
undetectable
5dzkI-4r5cA:
undetectable
5dzkW-4r5cA:
undetectable		 5dzkB-4r5cA:
21.71
5dzkI-4r5cA:
17.94
5dzkW-4r5cA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raa PUTATIVE EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF17170
(DUF5128) 		4 PHE A  34
GLY A 300
ILE A  32
LEU A 301
 None
 0.85A 5dzkB-4raaA:
undetectable
5dzkI-4raaA:
undetectable
5dzkW-4raaA:
undetectable		 5dzkB-4raaA:
22.79
5dzkI-4raaA:
19.55
5dzkW-4raaA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo sapiens) 		PF13489
(Methyltransf_23) 		4 PHE A 215
GLY A 199
ILE A 213
LEU A 201
 None
 0.82A 5dzkB-4rfqA:
undetectable
5dzkI-4rfqA:
undetectable
5dzkW-4rfqA:
undetectable		 5dzkB-4rfqA:
21.36
5dzkI-4rfqA:
21.11
5dzkW-4rfqA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49

(Pseudomonas
virus LKA1) 		PF13229
(Beta_helix) 		4 PHE A 442
ILE A 423
GLY A 448
ILE A 440
 None
 0.86A 5dzkB-4ru4A:
undetectable
5dzkI-4ru4A:
undetectable
5dzkW-4ru4A:
undetectable		 5dzkB-4ru4A:
16.06
5dzkI-4ru4A:
14.72
5dzkW-4ru4A:
0.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ttp DEPHOSPHO-COA KINASE

(Legionella
pneumophila) 		PF01121
(CoaE) 		4 ILE A  36
GLY A  12
ILE A 102
LEU A 115
 None
 0.70A 5dzkB-4ttpA:
undetectable
5dzkI-4ttpA:
undetectable
5dzkW-4ttpA:
undetectable		 5dzkB-4ttpA:
22.69
5dzkI-4ttpA:
24.29
5dzkW-4ttpA:
1.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF00574
(CLP_protease)
PF00574
(CLP_protease) 		4 PHE A 147
ILE H  71
GLY H 127
ILE H 146
 ZIL  H 301 ( 4.8A)
ZIL  H 301 (-3.6A)
ZIL  H 301 ( 3.5A)
ZIL  H 301 ( 3.3A)
 0.38A 5dzkB-4u0gA:
27.7
5dzkI-4u0gA:
31.4
5dzkW-4u0gA:
undetectable		 5dzkB-4u0gA:
100.00
5dzkI-4u0gA:
41.58
5dzkW-4u0gA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uip REPEBODY (RAC1)

(Listeria
monocytogenes;
Eptatretus
burgeri;
synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 PHE B  19
ILE B  44
GLY B  59
ILE B  47
 None
 0.85A 5dzkB-4uipB:
1.8
5dzkI-4uipB:
undetectable
5dzkW-4uipB:
undetectable		 5dzkB-4uipB:
21.84
5dzkI-4uipB:
21.24
5dzkW-4uipB:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wed ABC TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Sinorhizobium
meliloti) 		PF00496
(SBP_bac_5) 		5 PHE A 419
ILE A 385
GLY A 418
ILE A 381
LEU A 417
 None
 1.44A 5dzkB-4wedA:
undetectable
5dzkI-4wedA:
undetectable
5dzkW-4wedA:
undetectable		 5dzkB-4wedA:
19.31
5dzkI-4wedA:
17.39
5dzkW-4wedA:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xav GLIOMEDIN

(Mus musculus) 		PF02191
(OLF) 		4 PHE A 415
ILE A 444
GLY A 470
ILE A 434
 None
 0.87A 5dzkB-4xavA:
undetectable
5dzkI-4xavA:
undetectable
5dzkW-4xavA:
undetectable		 5dzkB-4xavA:
21.38
5dzkI-4xavA:
22.22
5dzkW-4xavA:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxk PHYCOBILIPROTEIN
APCE

(Nostoc sp. PCC
7120) 		PF00502
(Phycobilisome) 		4 ILE A  56
GLY A  50
ILE A 225
LEU A  54
 None
 0.80A 5dzkB-4xxkA:
undetectable
5dzkI-4xxkA:
undetectable
5dzkW-4xxkA:
undetectable		 5dzkB-4xxkA:
22.67
5dzkI-4xxkA:
24.10
5dzkW-4xxkA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Streptobacillus
moniliformis) 		PF13407
(Peripla_BP_4) 		4 ILE A 113
GLY A  30
ILE A 289
LEU A  88
 None
 0.84A 5dzkB-4z0nA:
undetectable
5dzkI-4z0nA:
undetectable
5dzkW-4z0nA:
undetectable		 5dzkB-4z0nA:
21.74
5dzkI-4z0nA:
20.47
5dzkW-4z0nA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis) 		no annotation 4 ILE A 573
GLY A 346
ILE A 556
LEU A 344
 None
FMN  A 900 (-3.4A)
None
None
 0.86A 5dzkB-4z38A:
2.3
5dzkI-4z38A:
2.8
5dzkW-4z38A:
undetectable		 5dzkB-4z38A:
19.75
5dzkI-4z38A:
17.06
5dzkW-4z38A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 ILE A1414
GLY A1308
ILE A1383
LEU A1376
 None
 0.81A 5dzkB-5a31A:
undetectable
5dzkI-5a31A:
undetectable
5dzkW-5a31A:
undetectable		 5dzkB-5a31A:
9.87
5dzkI-5a31A:
8.84
5dzkW-5a31A:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 ILE M 243
GLY M 234
ILE M 208
LEU M 241
 None
 0.78A 5dzkB-5a5tM:
undetectable
5dzkI-5a5tM:
undetectable
5dzkW-5a5tM:
undetectable		 5dzkB-5a5tM:
22.13
5dzkI-5a5tM:
21.97
5dzkW-5a5tM:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cya TUBULIN-SPECIFIC
CHAPERONE C

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 220
ILE A 212
ILE A 230
LEU A 190
 None
 0.85A 5dzkB-5cyaA:
undetectable
5dzkI-5cyaA:
1.7
5dzkW-5cyaA:
undetectable		 5dzkB-5cyaA:
21.94
5dzkI-5cyaA:
24.10
5dzkW-5cyaA:
0.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1r RV1816
TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		5 PHE A 179
ILE A 155
GLY A 181
ILE A 146
LEU A 157
 None
 1.38A 5dzkB-5d1rA:
undetectable
5dzkI-5d1rA:
undetectable
5dzkW-5d1rA:
undetectable		 5dzkB-5d1rA:
24.90
5dzkI-5d1rA:
25.91
5dzkW-5d1rA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ILE C 122
GLY C  88
ILE C 451
LEU C  70
 None
 0.82A 5dzkB-5fseC:
undetectable
5dzkI-5fseC:
undetectable
5dzkW-5fseC:
undetectable		 5dzkB-5fseC:
17.28
5dzkI-5fseC:
15.72
5dzkW-5fseC:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 4 ILE A 103
GLY A 216
ILE A 168
LEU A 161
 None
 0.75A 5dzkB-5gqfA:
undetectable
5dzkI-5gqfA:
undetectable
5dzkW-5gqfA:
undetectable		 5dzkB-5gqfA:
15.22
5dzkI-5gqfA:
14.08
5dzkW-5gqfA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41

(Homo sapiens) 		PF00270
(DEAD) 		5 PHE A 226
ILE A 212
GLY A 230
ILE A 396
LEU A 233
 None
 1.35A 5dzkB-5gvsA:
undetectable
5dzkI-5gvsA:
undetectable
5dzkW-5gvsA:
undetectable		 5dzkB-5gvsA:
22.98
5dzkI-5gvsA:
19.42
5dzkW-5gvsA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 PHE A 398
ILE A 191
GLY A 404
ILE A 166
 None
KCX  A 192 ( 3.8A)
None
KCX  A 192 ( 4.8A)
 0.80A 5dzkB-5hqlA:
2.2
5dzkI-5hqlA:
1.4
5dzkW-5hqlA:
undetectable		 5dzkB-5hqlA:
19.52
5dzkI-5hqlA:
18.45
5dzkW-5hqlA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		4 PHE A  12
ILE A  31
GLY A 173
ILE A   7
 None
 0.83A 5dzkB-5j44A:
undetectable
5dzkI-5j44A:
undetectable
5dzkW-5j44A:
undetectable		 5dzkB-5j44A:
11.52
5dzkI-5j44A:
11.05
5dzkW-5j44A:
0.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 ILE A 103
GLY A 125
ILE A  75
LEU A  40
 None
 0.82A 5dzkB-5jodA:
undetectable
5dzkI-5jodA:
undetectable
5dzkW-5jodA:
undetectable		 5dzkB-5jodA:
19.20
5dzkI-5jodA:
20.11
5dzkW-5jodA:
0.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 ILE S 198
GLY S  58
ILE S 190
LEU S 169
 None
 0.82A 5dzkB-5k0yS:
undetectable
5dzkI-5k0yS:
undetectable
5dzkW-5k0yS:
undetectable		 5dzkB-5k0yS:
18.03
5dzkI-5k0yS:
19.26
5dzkW-5k0yS:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB) 		4 ILE A 435
GLY A 413
ILE A 264
LEU A 290
 None
 0.82A 5dzkB-5kwaA:
3.1
5dzkI-5kwaA:
3.0
5dzkW-5kwaA:
undetectable		 5dzkB-5kwaA:
19.62
5dzkI-5kwaA:
19.05
5dzkW-5kwaA:
14.29