SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_V_BEZV801_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ble FRUCTOSE PERMEASE

(Bacillus
subtilis) 		PF03830
(PTSIIB_sorb) 		4 ILE A  48
ILE A  38
ARG A  44
LEU A  83
 None
 1.14A 5dzkh-1bleA:
0.0
5dzkn-1bleA:
0.0
5dzkv-1bleA:
undetectable		 5dzkh-1bleA:
22.77
5dzkn-1bleA:
22.77
5dzkv-1bleA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 ILE A 197
ILE A 220
ARG A 225
LEU A 191
 None
 0.90A 5dzkh-1d0nA:
0.0
5dzkn-1d0nA:
0.0
5dzkv-1d0nA:
undetectable		 5dzkh-1d0nA:
14.50
5dzkn-1d0nA:
14.50
5dzkv-1d0nA:
1.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		4 ILE A 168
ILE A  39
ARG A 143
LEU A 195
 None
 1.18A 5dzkh-1eepA:
1.7
5dzkn-1eepA:
1.6
5dzkv-1eepA:
undetectable		 5dzkh-1eepA:
19.55
5dzkn-1eepA:
19.55
5dzkv-1eepA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hi9 DIPEPTIDE TRANSPORT
PROTEIN DPPA

(Bacillus
subtilis) 		PF04951
(Peptidase_M55) 		4 ILE A  34
ILE A  12
ARG A 190
LEU A  33
 None
 1.39A 5dzkh-1hi9A:
0.6
5dzkn-1hi9A:
0.8
5dzkv-1hi9A:
undetectable		 5dzkh-1hi9A:
21.71
5dzkn-1hi9A:
21.71
5dzkv-1hi9A:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9c GLUTAMATE MUTASE

(Clostridium
cochlearium) 		PF02310
(B12-binding) 		4 ILE A  58
ILE A  86
ARG A  75
LEU A  59
 None
None
None
B12  A 800 ( 4.2A)
 1.23A 5dzkh-1i9cA:
1.1
5dzkn-1i9cA:
1.1
5dzkv-1i9cA:
undetectable		 5dzkh-1i9cA:
20.10
5dzkn-1i9cA:
20.10
5dzkv-1i9cA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsd HAEMAGGLUTININ (HA1
CHAIN)

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ILE A 166
ILE A 114
ARG A 162
LEU A 250
 None
 1.29A 5dzkh-1jsdA:
0.0
5dzkn-1jsdA:
0.0
5dzkv-1jsdA:
undetectable		 5dzkh-1jsdA:
16.98
5dzkn-1jsdA:
16.98
5dzkv-1jsdA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		4 ILE A 245
ILE A 272
ARG A 260
LEU A 216
 None
 1.33A 5dzkh-1k0fA:
0.0
5dzkn-1k0fA:
undetectable
5dzkv-1k0fA:
undetectable		 5dzkh-1k0fA:
20.85
5dzkn-1k0fA:
20.85
5dzkv-1k0fA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin) 		4 ILE A 201
ILE A 187
ARG A 274
LEU A 200
 None
 1.05A 5dzkh-1ldkA:
undetectable
5dzkn-1ldkA:
0.0
5dzkv-1ldkA:
undetectable		 5dzkh-1ldkA:
19.24
5dzkn-1ldkA:
19.24
5dzkv-1ldkA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lme PEPTIDE DEFORMYLASE

(Thermotoga
maritima) 		PF01327
(Pep_deformylase) 		4 ILE A 139
ILE A  97
ARG A  99
LEU A 138
 OCS  A  87 ( 4.6A)
None
None
OCS  A  87 ( 4.8A)
 1.34A 5dzkh-1lmeA:
undetectable
5dzkn-1lmeA:
0.0
5dzkv-1lmeA:
undetectable		 5dzkh-1lmeA:
21.60
5dzkn-1lmeA:
21.60
5dzkv-1lmeA:
1.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF01798
(Nop) 		4 ILE B 128
ILE B 102
ARG B 132
LEU B 109
 None
 1.14A 5dzkh-1nt2B:
undetectable
5dzkn-1nt2B:
undetectable
5dzkv-1nt2B:
undetectable		 5dzkh-1nt2B:
22.10
5dzkn-1nt2B:
22.10
5dzkv-1nt2B:
1.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6y HYPOTHETICAL PROTEIN
YFDW

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		4 ILE A  94
ILE A 122
ARG A 189
LEU A  13
 None
 1.35A 5dzkh-1q6yA:
undetectable
5dzkn-1q6yA:
undetectable
5dzkv-1q6yA:
undetectable		 5dzkh-1q6yA:
21.03
5dzkn-1q6yA:
21.03
5dzkv-1q6yA:
1.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qez PROTEIN (INORGANIC
PYROPHOSPHATASE)

(Sulfolobus
acidocaldarius) 		PF00719
(Pyrophosphatase) 		4 ILE A1102
ILE A1089
ARG A1161
LEU A1069
 None
 1.27A 5dzkh-1qezA:
undetectable
5dzkn-1qezA:
undetectable
5dzkv-1qezA:
undetectable		 5dzkh-1qezA:
24.06
5dzkn-1qezA:
24.06
5dzkv-1qezA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 ILE G 197
ILE G 220
ARG G 225
LEU G 191
 None
 0.88A 5dzkh-1rgiG:
undetectable
5dzkn-1rgiG:
undetectable
5dzkv-1rgiG:
undetectable		 5dzkh-1rgiG:
19.43
5dzkn-1rgiG:
19.43
5dzkv-1rgiG:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 117
ILE A 149
ARG A 159
LEU A 130
 None
 1.09A 5dzkh-1rrhA:
undetectable
5dzkn-1rrhA:
undetectable
5dzkv-1rrhA:
undetectable		 5dzkh-1rrhA:
12.66
5dzkn-1rrhA:
12.66
5dzkv-1rrhA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqi 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Rattus
norvegicus) 		PF00903
(Glyoxalase) 		4 ILE A 322
ILE A 278
ARG A 282
LEU A 323
 None
 1.09A 5dzkh-1sqiA:
undetectable
5dzkn-1sqiA:
undetectable
5dzkv-1sqiA:
undetectable		 5dzkh-1sqiA:
18.18
5dzkn-1sqiA:
18.18
5dzkv-1sqiA:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ILE A 163
ILE A  91
ARG A  85
LEU A 162
 None
 1.32A 5dzkh-1uliA:
undetectable
5dzkn-1uliA:
undetectable
5dzkv-1uliA:
undetectable		 5dzkh-1uliA:
19.54
5dzkn-1uliA:
19.54
5dzkv-1uliA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A 364
ILE A 259
ARG A 257
LEU A 363
 ILE  A 364 ( 0.7A)
ILE  A 259 ( 0.4A)
ARG  A 257 ( 0.6A)
LEU  A 363 ( 0.6A)
 1.30A 5dzkh-1wqaA:
undetectable
5dzkn-1wqaA:
undetectable
5dzkv-1wqaA:
undetectable		 5dzkh-1wqaA:
18.86
5dzkn-1wqaA:
18.86
5dzkv-1wqaA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ILE A 173
ILE A  94
ARG A  88
LEU A 172
 None
 1.27A 5dzkh-1wqlA:
undetectable
5dzkn-1wqlA:
undetectable
5dzkv-1wqlA:
undetectable		 5dzkh-1wqlA:
17.58
5dzkn-1wqlA:
17.58
5dzkv-1wqlA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Streptococcus
pyogenes) 		PF04131
(NanE) 		4 ILE A 124
ILE A 120
ARG A 114
LEU A 136
 None
 1.26A 5dzkh-1yxyA:
undetectable
5dzkn-1yxyA:
undetectable
5dzkv-1yxyA:
undetectable		 5dzkh-1yxyA:
26.72
5dzkn-1yxyA:
26.72
5dzkv-1yxyA:
1.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6e RNA POLYMERASE SIGMA
FACTOR RPOD

(Thermus
thermophilus) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		4 ILE F 127
ILE F 113
ARG F 128
LEU F 122
 None
 1.32A 5dzkh-2a6eF:
undetectable
5dzkn-2a6eF:
undetectable
5dzkv-2a6eF:
undetectable		 5dzkh-2a6eF:
20.10
5dzkn-2a6eF:
20.10
5dzkv-2a6eF:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		4 ILE A  69
ILE A  63
ARG A  58
LEU A  70
 None
 0.98A 5dzkh-2bi3A:
undetectable
5dzkn-2bi3A:
undetectable
5dzkv-2bi3A:
undetectable		 5dzkh-2bi3A:
20.27
5dzkn-2bi3A:
20.27
5dzkv-2bi3A:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0z NOVW

(Streptomyces
niveus) 		PF00908
(dTDP_sugar_isom) 		4 ILE A   8
ILE A 117
ARG A  89
LEU A   6
 None
 1.31A 5dzkh-2c0zA:
undetectable
5dzkn-2c0zA:
undetectable
5dzkv-2c0zA:
undetectable		 5dzkh-2c0zA:
21.27
5dzkn-2c0zA:
21.27
5dzkv-2c0zA:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE

(Bacillus
subtilis) 		PF12710
(HAD) 		4 ILE A  77
ILE A 113
ARG A  82
LEU A 109
 None
 1.21A 5dzkh-2feaA:
undetectable
5dzkn-2feaA:
undetectable
5dzkv-2feaA:
undetectable		 5dzkh-2feaA:
21.51
5dzkn-2feaA:
21.51
5dzkv-2feaA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gl5 PUTATIVE DEHYDRATASE
PROTEIN

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 244
ILE A 219
ARG A 210
LEU A 246
 None
 1.07A 5dzkh-2gl5A:
3.2
5dzkn-2gl5A:
3.3
5dzkv-2gl5A:
undetectable		 5dzkh-2gl5A:
20.25
5dzkn-2gl5A:
20.25
5dzkv-2gl5A:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtl HEMOGLOBIN LINKER
CHAIN L1
EXTRACELLULAR
HEMOGLOBIN LINKER L3
SUBUNIT

(Lumbricus
terrestris;
Lumbricus
terrestris) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C)
PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		4 ILE O  24
ILE M  21
ARG O  20
LEU M  28
 None
 1.12A 5dzkh-2gtlO:
undetectable
5dzkn-2gtlO:
undetectable
5dzkv-2gtlO:
undetectable		 5dzkh-2gtlO:
22.88
5dzkn-2gtlO:
22.88
5dzkv-2gtlO:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE A  95
ILE A 139
ARG A 137
LEU A  97
 None
 1.09A 5dzkh-2idcA:
undetectable
5dzkn-2idcA:
undetectable
5dzkv-2idcA:
undetectable		 5dzkh-2idcA:
23.00
5dzkn-2idcA:
23.00
5dzkv-2idcA:
2.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 858
ILE A 643
ARG A 847
LEU A 844
 None
 1.22A 5dzkh-2iukA:
undetectable
5dzkn-2iukA:
undetectable
5dzkv-2iukA:
undetectable		 5dzkh-2iukA:
12.33
5dzkn-2iukA:
12.33
5dzkv-2iukA:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mb9 B-CELL
LYMPHOMA/LEUKEMIA 10

(Homo sapiens) 		PF00619
(CARD) 		4 ILE A  86
ILE A  96
ARG A  87
LEU A  82
 None
 1.31A 5dzkh-2mb9A:
undetectable
5dzkn-2mb9A:
undetectable
5dzkv-2mb9A:
undetectable		 5dzkh-2mb9A:
20.00
5dzkn-2mb9A:
20.00
5dzkv-2mb9A:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv0 GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Bacillus
subtilis) 		PF01174
(SNO) 		4 ILE A  84
ILE A  56
ARG A  53
LEU A  85
 None
 1.33A 5dzkh-2nv0A:
undetectable
5dzkn-2nv0A:
undetectable
5dzkv-2nv0A:
undetectable		 5dzkh-2nv0A:
22.67
5dzkn-2nv0A:
22.67
5dzkv-2nv0A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ILE A 459
ILE A 124
ARG A 120
LEU A 458
 None
 1.24A 5dzkh-2pajA:
undetectable
5dzkn-2pajA:
undetectable
5dzkv-2pajA:
undetectable		 5dzkh-2pajA:
18.82
5dzkn-2pajA:
18.82
5dzkv-2pajA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pia PHTHALATE
DIOXYGENASE
REDUCTASE

(Burkholderia
cepacia) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ILE A 257
ILE A 251
ARG A 311
LEU A 258
 None
 1.33A 5dzkh-2piaA:
undetectable
5dzkn-2piaA:
undetectable
5dzkv-2piaA:
undetectable		 5dzkh-2piaA:
20.67
5dzkn-2piaA:
20.67
5dzkv-2piaA:
0.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pid TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 ILE A 329
ILE A 332
ARG A 348
LEU A 326
 None
 1.39A 5dzkh-2pidA:
undetectable
5dzkn-2pidA:
undetectable
5dzkv-2pidA:
undetectable		 5dzkh-2pidA:
18.77
5dzkn-2pidA:
18.77
5dzkv-2pidA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvg TWO COMPONENT
RESPONSE REGULATOR

(Legionella
pneumophila) 		PF00072
(Response_reg) 		4 ILE A  63
ILE A  90
ARG A  82
LEU A  64
 None
 1.27A 5dzkh-2qvgA:
undetectable
5dzkn-2qvgA:
undetectable
5dzkv-2qvgA:
undetectable		 5dzkh-2qvgA:
20.98
5dzkn-2qvgA:
20.98
5dzkv-2qvgA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x06 L-SULFOLACTATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF02615
(Ldh_2) 		4 ILE A 218
ILE A 184
ARG A 181
LEU A 219
 None
 1.28A 5dzkh-2x06A:
undetectable
5dzkn-2x06A:
undetectable
5dzkv-2x06A:
undetectable		 5dzkh-2x06A:
22.32
5dzkn-2x06A:
22.32
5dzkv-2x06A:
0.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adc L-SERYL-TRNA(SEC)
KINASE

(Methanocaldococcus
jannaschii) 		PF08433
(KTI12) 		4 ILE A  39
ILE A  54
ARG A  40
LEU A  61
 None
None
C  C  75 ( 3.1A)
None
 1.18A 5dzkh-3adcA:
undetectable
5dzkn-3adcA:
undetectable
5dzkv-3adcA:
undetectable		 5dzkh-3adcA:
23.37
5dzkn-3adcA:
23.37
5dzkv-3adcA:
0.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg1 PROTEIN SEC13
HOMOLOG

(Homo sapiens) 		PF00400
(WD40) 		4 ILE A  85
ILE A  73
ARG A  87
LEU A 132
 None
 1.06A 5dzkh-3bg1A:
undetectable
5dzkn-3bg1A:
undetectable
5dzkv-3bg1A:
undetectable		 5dzkh-3bg1A:
21.94
5dzkn-3bg1A:
21.94
5dzkv-3bg1A:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dee PUTATIVE REGULATORY
PROTEIN

(Neisseria
gonorrhoeae) 		PF09836
(DUF2063) 		4 ILE A 226
ILE A 118
ARG A 223
LEU A 229
 None
 1.24A 5dzkh-3deeA:
undetectable
5dzkn-3deeA:
undetectable
5dzkv-3deeA:
undetectable		 5dzkh-3deeA:
22.05
5dzkn-3deeA:
22.05
5dzkv-3deeA:
1.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE

(Neisseria
meningitidis) 		PF01225
(Mur_ligase)
PF08245
(Mur_ligase_M) 		4 ILE A 298
ILE A 308
ARG A 302
LEU A 295
 None
 1.26A 5dzkh-3eagA:
undetectable
5dzkn-3eagA:
undetectable
5dzkv-3eagA:
undetectable		 5dzkh-3eagA:
21.10
5dzkn-3eagA:
21.10
5dzkv-3eagA:
0.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb2 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Rhodopseudomonas
palustris) 		PF00701
(DHDPS) 		4 ILE A 151
ILE A 176
ARG A 172
LEU A 154
 None
 1.22A 5dzkh-3eb2A:
1.9
5dzkn-3eb2A:
1.9
5dzkv-3eb2A:
undetectable		 5dzkh-3eb2A:
20.39
5dzkn-3eb2A:
20.39
5dzkv-3eb2A:
1.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE

(Rhodobacter
sphaeroides) 		PF01323
(DSBA) 		4 ILE A   4
ILE A 194
ARG A  31
LEU A 175
 None
 1.14A 5dzkh-3fz5A:
undetectable
5dzkn-3fz5A:
undetectable
5dzkv-3fz5A:
undetectable		 5dzkh-3fz5A:
22.02
5dzkn-3fz5A:
22.02
5dzkv-3fz5A:
1.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlz UNCHARACTERIZED
PROTEIN BT_1490

(Bacteroides
thetaiotaomicron) 		PF12712
(DUF3805)
PF12713
(DUF3806) 		4 ILE A 223
ILE A   7
ARG A 132
LEU A 142
 None
 1.06A 5dzkh-3hlzA:
undetectable
5dzkn-3hlzA:
undetectable
5dzkv-3hlzA:
undetectable		 5dzkh-3hlzA:
22.47
5dzkn-3hlzA:
22.47
5dzkv-3hlzA:
1.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlz UNCHARACTERIZED
PROTEIN BT_1490

(Bacteroides
thetaiotaomicron) 		PF12712
(DUF3805)
PF12713
(DUF3806) 		4 ILE A 223
ILE A   7
ARG A 132
LEU A 222
 None
 1.08A 5dzkh-3hlzA:
undetectable
5dzkn-3hlzA:
undetectable
5dzkv-3hlzA:
undetectable		 5dzkh-3hlzA:
22.47
5dzkn-3hlzA:
22.47
5dzkv-3hlzA:
1.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE

(Bacillus
anthracis) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A   5
ILE A 316
ARG A   3
LEU A 110
 None
 1.25A 5dzkh-3icsA:
undetectable
5dzkn-3icsA:
undetectable
5dzkv-3icsA:
undetectable		 5dzkh-3icsA:
18.96
5dzkn-3icsA:
18.96
5dzkv-3icsA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ILE A 157
ILE A 152
ARG A 147
LEU A 388
 None
 1.11A 5dzkh-3kdnA:
1.1
5dzkn-3kdnA:
1.1
5dzkv-3kdnA:
undetectable		 5dzkh-3kdnA:
19.38
5dzkn-3kdnA:
19.38
5dzkv-3kdnA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1

(Homo sapiens) 		PF01369
(Sec7) 		4 ILE A 831
ILE A 882
ARG A 782
LEU A 834
 None
 1.14A 5dzkh-3ltlA:
undetectable
5dzkn-3ltlA:
undetectable
5dzkv-3ltlA:
undetectable		 5dzkh-3ltlA:
19.73
5dzkn-3ltlA:
19.73
5dzkv-3ltlA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 ILE A 291
ILE A 286
ARG A 289
LEU A 258
 None
 1.31A 5dzkh-3m07A:
undetectable
5dzkn-3m07A:
undetectable
5dzkv-3m07A:
undetectable		 5dzkh-3m07A:
15.81
5dzkn-3m07A:
15.81
5dzkv-3m07A:
1.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		4 ILE A 216
ILE A 248
ARG A 217
LEU A 202
 None
 1.34A 5dzkh-3mznA:
1.0
5dzkn-3mznA:
1.0
5dzkv-3mznA:
undetectable		 5dzkh-3mznA:
18.75
5dzkn-3mznA:
18.75
5dzkv-3mznA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		4 ILE A  98
ILE A 111
ARG A 102
LEU A 124
 None
 1.34A 5dzkh-3nm1A:
undetectable
5dzkn-3nm1A:
undetectable
5dzkv-3nm1A:
undetectable		 5dzkh-3nm1A:
16.82
5dzkn-3nm1A:
16.82
5dzkv-3nm1A:
0.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2

(Homo sapiens) 		PF01369
(Sec7) 		4 ILE A 822
ILE A 827
ARG A 727
LEU A 783
 None
 1.39A 5dzkh-3swvA:
undetectable
5dzkn-3swvA:
undetectable
5dzkv-3swvA:
undetectable		 5dzkh-3swvA:
21.20
5dzkn-3swvA:
21.20
5dzkv-3swvA:
0.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Roseiflexus sp.
RS-1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 188
ILE A 168
ARG A 187
LEU A 200
 None
 1.04A 5dzkh-3u9iA:
undetectable
5dzkn-3u9iA:
undetectable
5dzkv-3u9iA:
undetectable		 5dzkh-3u9iA:
21.93
5dzkn-3u9iA:
21.93
5dzkv-3u9iA:
0.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 ILE A 127
ILE A 174
ARG A 172
LEU A 123
 None
 1.32A 5dzkh-3vc7A:
1.6
5dzkn-3vc7A:
1.7
5dzkv-3vc7A:
undetectable		 5dzkh-3vc7A:
26.24
5dzkn-3vc7A:
26.24
5dzkv-3vc7A:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		4 ILE A 466
ILE A 463
ARG A 458
LEU A 549
 None
 1.36A 5dzkh-3welA:
undetectable
5dzkn-3welA:
undetectable
5dzkv-3welA:
undetectable		 5dzkh-3welA:
12.60
5dzkn-3welA:
12.60
5dzkv-3welA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 ILE A   6
ILE A 178
ARG A 180
LEU A   8
 None
 1.14A 5dzkh-4acaA:
undetectable
5dzkn-4acaA:
undetectable
5dzkv-4acaA:
undetectable		 5dzkh-4acaA:
18.48
5dzkn-4acaA:
18.48
5dzkv-4acaA:
0.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 ILE A   6
ILE A 178
ARG A 180
LEU A  85
 None
 1.35A 5dzkh-4acaA:
undetectable
5dzkn-4acaA:
undetectable
5dzkv-4acaA:
undetectable		 5dzkh-4acaA:
18.48
5dzkn-4acaA:
18.48
5dzkv-4acaA:
0.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ILE A 528
ILE A 499
ARG A 507
LEU A 468
 None
 1.19A 5dzkh-4acqA:
undetectable
5dzkn-4acqA:
undetectable
5dzkv-4acqA:
undetectable		 5dzkh-4acqA:
9.29
5dzkn-4acqA:
9.29
5dzkv-4acqA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 ILE A  58
ILE A  82
ARG A  77
LEU A  59
 None
 1.35A 5dzkh-4b09A:
undetectable
5dzkn-4b09A:
undetectable
5dzkv-4b09A:
undetectable		 5dzkh-4b09A:
22.39
5dzkn-4b09A:
22.39
5dzkv-4b09A:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		4 ILE A 379
ILE A 393
ARG A 397
LEU A 381
 None
 1.27A 5dzkh-4conA:
2.1
5dzkn-4conA:
2.1
5dzkv-4conA:
undetectable		 5dzkh-4conA:
15.11
5dzkn-4conA:
15.11
5dzkv-4conA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 141
ILE A  64
ARG A  67
LEU A 173
 None
 1.07A 5dzkh-4e3cA:
undetectable
5dzkn-4e3cA:
undetectable
5dzkv-4e3cA:
undetectable		 5dzkh-4e3cA:
14.95
5dzkn-4e3cA:
14.95
5dzkv-4e3cA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		4 ILE A 275
ILE A 370
ARG A 374
LEU A 273
 None
 1.15A 5dzkh-4eb5A:
undetectable
5dzkn-4eb5A:
undetectable
5dzkv-4eb5A:
undetectable		 5dzkh-4eb5A:
19.74
5dzkn-4eb5A:
19.74
5dzkv-4eb5A:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE

(Mycobacterium
sp. JLS) 		PF04471
(Mrr_cat) 		4 ILE A 183
ILE A 256
ARG A 253
LEU A 208
 None
 0.86A 5dzkh-4f0qA:
undetectable
5dzkn-4f0qA:
undetectable
5dzkv-4f0qA:
undetectable		 5dzkh-4f0qA:
17.42
5dzkn-4f0qA:
17.42
5dzkv-4f0qA:
0.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 156
ILE A 142
ARG A  60
LEU A 155
 None
 1.37A 5dzkh-4f7kA:
undetectable
5dzkn-4f7kA:
undetectable
5dzkv-4f7kA:
undetectable		 5dzkh-4f7kA:
18.18
5dzkn-4f7kA:
18.18
5dzkv-4f7kA:
0.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 ILE A 525
ILE A 441
ARG A 567
LEU A 524
 None
 1.18A 5dzkh-4flnA:
undetectable
5dzkn-4flnA:
undetectable
5dzkv-4flnA:
undetectable		 5dzkh-4flnA:
16.35
5dzkn-4flnA:
16.35
5dzkv-4flnA:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfi MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 197
ILE A 172
ARG A 164
LEU A 199
 None
 1.38A 5dzkh-4gfiA:
1.9
5dzkn-4gfiA:
1.9
5dzkv-4gfiA:
undetectable		 5dzkh-4gfiA:
21.75
5dzkn-4gfiA:
21.75
5dzkv-4gfiA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		4 ILE A 401
ILE A 288
ARG A 286
LEU A 399
 None
 1.08A 5dzkh-4go4A:
undetectable
5dzkn-4go4A:
undetectable
5dzkv-4go4A:
undetectable		 5dzkh-4go4A:
17.92
5dzkn-4go4A:
17.92
5dzkv-4go4A:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxi KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		4 ILE A 105
ILE A  61
ARG A  44
LEU A 104
 None
 1.29A 5dzkh-4hxiA:
undetectable
5dzkn-4hxiA:
undetectable
5dzkv-4hxiA:
undetectable		 5dzkh-4hxiA:
21.43
5dzkn-4hxiA:
21.43
5dzkv-4hxiA:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		4 ILE A 300
ILE A 266
ARG A 270
LEU A 279
 None
 0.93A 5dzkh-4kv7A:
undetectable
5dzkn-4kv7A:
undetectable
5dzkv-4kv7A:
undetectable		 5dzkh-4kv7A:
20.74
5dzkn-4kv7A:
20.74
5dzkv-4kv7A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljs PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 ILE A 174
ILE A 191
ARG A 175
LEU A 315
 None
 1.18A 5dzkh-4ljsA:
undetectable
5dzkn-4ljsA:
undetectable
5dzkv-4ljsA:
undetectable		 5dzkh-4ljsA:
20.67
5dzkn-4ljsA:
20.67
5dzkv-4ljsA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maf ATP SULFURYLASE

(Glycine max) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A 178
ILE A 196
ARG A 177
LEU A 189
 None
 1.29A 5dzkh-4mafA:
undetectable
5dzkn-4mafA:
undetectable
5dzkv-4mafA:
undetectable		 5dzkh-4mafA:
21.46
5dzkn-4mafA:
21.46
5dzkv-4mafA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 203
ILE A 229
ARG A 233
LEU A 202
 None
 1.17A 5dzkh-4nfyA:
undetectable
5dzkn-4nfyA:
undetectable
5dzkv-4nfyA:
undetectable		 5dzkh-4nfyA:
20.85
5dzkn-4nfyA:
20.85
5dzkv-4nfyA:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ILE A  64
ILE A  61
ARG A 103
LEU A  66
 None
 1.28A 5dzkh-4pj3A:
undetectable
5dzkn-4pj3A:
undetectable
5dzkv-4pj3A:
undetectable		 5dzkh-4pj3A:
8.86
5dzkn-4pj3A:
8.86
5dzkv-4pj3A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ILE A  64
ILE A  61
ARG A 103
LEU A  67
 None
 1.35A 5dzkh-4pj3A:
undetectable
5dzkn-4pj3A:
undetectable
5dzkv-4pj3A:
undetectable		 5dzkh-4pj3A:
8.86
5dzkn-4pj3A:
8.86
5dzkv-4pj3A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s10 GELSOLIN

(Homo sapiens) 		PF00626
(Gelsolin) 		4 ILE C 197
ILE C 220
ARG C 225
LEU C 191
 None
 0.91A 5dzkh-4s10C:
undetectable
5dzkn-4s10C:
undetectable
5dzkv-4s10C:
undetectable		 5dzkh-4s10C:
20.42
5dzkn-4s10C:
20.42
5dzkv-4s10C:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2m BETA-LACTAMASE

(Enterobacter
cloacae) 		PF00905
(Transpeptidase) 		4 ILE A  79
ILE A 130
ARG A 134
LEU A  81
 None
 1.25A 5dzkh-4s2mA:
undetectable
5dzkn-4s2mA:
undetectable
5dzkv-4s2mA:
undetectable		 5dzkh-4s2mA:
20.80
5dzkn-4s2mA:
20.80
5dzkv-4s2mA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN

(Chlamydomonas
reinhardtii) 		PF12895
(ANAPC3)
PF13174
(TPR_6) 		4 ILE A 537
ILE A 541
ARG A 557
LEU A 511
 None
 1.32A 5dzkh-4uzyA:
undetectable
5dzkn-4uzyA:
undetectable
5dzkv-4uzyA:
undetectable		 5dzkh-4uzyA:
14.89
5dzkn-4uzyA:
14.89
5dzkv-4uzyA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xh3 ACTIN-BINDING
PROTEIN ANILLIN

(Homo sapiens) 		PF08174
(Anillin) 		4 ILE A 124
ILE A  54
ARG A  50
LEU A 125
 None
 1.19A 5dzkh-4xh3A:
undetectable
5dzkn-4xh3A:
undetectable
5dzkv-4xh3A:
undetectable		 5dzkh-4xh3A:
19.61
5dzkn-4xh3A:
19.61
5dzkv-4xh3A:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xoi ACTIN-BINDING
PROTEIN ANILLIN

(Homo sapiens) 		PF08174
(Anillin) 		4 ILE B 124
ILE B  54
ARG B  50
LEU B 125
 None
 1.18A 5dzkh-4xoiB:
undetectable
5dzkn-4xoiB:
undetectable
5dzkv-4xoiB:
undetectable		 5dzkh-4xoiB:
19.85
5dzkn-4xoiB:
19.85
5dzkv-4xoiB:
1.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus) 		PF01398
(JAB)
PF13012
(MitMem_reg) 		4 ILE F 206
ILE F 137
ARG F 135
LEU F 205
 None
 1.40A 5dzkh-5a5tF:
undetectable
5dzkn-5a5tF:
undetectable
5dzkv-5a5tF:
undetectable		 5dzkh-5a5tF:
17.98
5dzkn-5a5tF:
17.98
5dzkv-5a5tF:
0.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buv PUTATIVE EPIMERASE

(Yersinia
enterocolitica) 		PF00908
(dTDP_sugar_isom) 		4 ILE A  10
ILE A 118
ARG A  90
LEU A   8
 None
 1.18A 5dzkh-5buvA:
undetectable
5dzkn-5buvA:
undetectable
5dzkv-5buvA:
undetectable		 5dzkh-5buvA:
19.90
5dzkn-5buvA:
19.90
5dzkv-5buvA:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF13476
(AAA_23) 		4 ILE A 155
ILE A1234
ARG A1220
LEU A  47
 None
AES  A1403 ( 4.6A)
None
None
 1.36A 5dzkh-5dacA:
undetectable
5dzkn-5dacA:
undetectable
5dzkv-5dacA:
undetectable		 5dzkh-5dacA:
17.69
5dzkn-5dacA:
17.69
5dzkv-5dacA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ILE A  16
ILE A 351
ARG A 634
LEU A  17
 None
 0.84A 5dzkh-5dfaA:
undetectable
5dzkn-5dfaA:
undetectable
5dzkv-5dfaA:
undetectable		 5dzkh-5dfaA:
15.48
5dzkn-5dfaA:
15.48
5dzkv-5dfaA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 ILE A 215
ILE A 206
ARG A 145
LEU A 218
 None
 1.31A 5dzkh-5e8hA:
undetectable
5dzkn-5e8hA:
undetectable
5dzkv-5e8hA:
undetectable		 5dzkh-5e8hA:
21.34
5dzkn-5e8hA:
21.34
5dzkv-5e8hA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 ILE A 215
ILE A 206
ARG A 145
LEU A 218
 None
 1.30A 5dzkh-5e8lA:
undetectable
5dzkn-5e8lA:
undetectable
5dzkv-5e8lA:
undetectable		 5dzkh-5e8lA:
22.73
5dzkn-5e8lA:
22.73
5dzkv-5e8lA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Homo sapiens) 		PF00903
(Glyoxalase)
PF13669
(Glyoxalase_4) 		4 ILE A 322
ILE A 278
ARG A 282
LEU A 323
 ILE  A 322 ( 0.6A)
ILE  A 278 ( 0.6A)
ARG  A 282 ( 0.6A)
LEU  A 323 ( 0.6A)
 1.16A 5dzkh-5ec3A:
undetectable
5dzkn-5ec3A:
undetectable
5dzkv-5ec3A:
undetectable		 5dzkh-5ec3A:
19.05
5dzkn-5ec3A:
19.05
5dzkv-5ec3A:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5faf GELSOLIN

(Homo sapiens) 		PF00626
(Gelsolin) 		4 ILE A 197
ILE A 220
ARG A 225
LEU A 191
 None
GOL  A 302 (-4.3A)
None
None
 0.78A 5dzkh-5fafA:
undetectable
5dzkn-5fafA:
undetectable
5dzkv-5fafA:
undetectable		 5dzkh-5fafA:
19.80
5dzkn-5fafA:
19.80
5dzkv-5fafA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		4 ILE A 518
ILE A 451
ARG A 289
LEU A 521
 None
 0.92A 5dzkh-5fdnA:
undetectable
5dzkn-5fdnA:
undetectable
5dzkv-5fdnA:
undetectable		 5dzkh-5fdnA:
11.74
5dzkn-5fdnA:
11.74
5dzkv-5fdnA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffx MARR FAMILY
REGULATORY PROTEIN

(Staphylococcus
aureus) 		PF12802
(MarR_2) 		4 ILE A  77
ILE A  91
ARG A  79
LEU A  37
 None
None
SO4  A 202 ( 3.9A)
None
 1.40A 5dzkh-5ffxA:
undetectable
5dzkn-5ffxA:
undetectable
5dzkv-5ffxA:
undetectable		 5dzkh-5ffxA:
19.70
5dzkn-5ffxA:
19.70
5dzkv-5ffxA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkw DNA POLYMERASE III
EPSILON

(Escherichia
coli) 		PF00929
(RNase_T) 		4 ILE D 170
ILE D 154
ARG D 159
LEU D 171
 None
 1.39A 5dzkh-5fkwD:
undetectable
5dzkn-5fkwD:
undetectable
5dzkv-5fkwD:
undetectable		 5dzkh-5fkwD:
23.32
5dzkn-5fkwD:
23.32
5dzkv-5fkwD:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjn LD10117P

(Drosophila
melanogaster) 		PF00566
(RabGAP-TBC) 		4 ILE A  62
ILE A  77
ARG A  57
LEU A  66
 None
 1.23A 5dzkh-5hjnA:
undetectable
5dzkn-5hjnA:
undetectable
5dzkv-5hjnA:
undetectable		 5dzkh-5hjnA:
20.16
5dzkn-5hjnA:
20.16
5dzkv-5hjnA:
0.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2u CELLULASE

(soil metagenome) 		PF00150
(Cellulase) 		4 ILE A 197
ILE A 160
ARG A 164
LEU A 173
 None
 1.00A 5dzkh-5i2uA:
1.8
5dzkn-5i2uA:
undetectable
5dzkv-5i2uA:
undetectable		 5dzkh-5i2uA:
21.56
5dzkn-5i2uA:
21.56
5dzkv-5i2uA:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		4 ILE A 280
ILE A 179
ARG A 283
LEU A 172
 None
 1.39A 5dzkh-5ko5A:
undetectable
5dzkn-5ko5A:
undetectable
5dzkv-5ko5A:
undetectable		 5dzkh-5ko5A:
24.32
5dzkn-5ko5A:
24.32
5dzkv-5ko5A:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsj KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG

(Homo sapiens;
Homo sapiens) 		PF08202
(MIS13)
no annotation 		4 ILE N 147
ILE D 239
ARG D 242
LEU N 148
 None
 1.08A 5dzkh-5lsjN:
undetectable
5dzkn-5lsjN:
undetectable
5dzkv-5lsjN:
undetectable		 5dzkh-5lsjN:
20.11
5dzkn-5lsjN:
20.11
5dzkv-5lsjN:
0.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uif PS01740

(Pseudomonas sp.
UW4) 		no annotation 4 ILE A  79
ILE A  27
ARG A  30
LEU A  80
 None
 1.30A 5dzkh-5uifA:
undetectable
5dzkn-5uifA:
undetectable
5dzkv-5uifA:
undetectable		 5dzkh-5uifA:
undetectable
5dzkn-5uifA:
undetectable
5dzkv-5uifA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wln TYPE II SECRETION
SYSTEM PROTEIN D

(Pseudomonas
aeruginosa) 		no annotation 4 ILE G 333
ILE G 485
ARG G 505
LEU G 414
 None
 1.00A 5dzkh-5wlnG:
undetectable
5dzkn-5wlnG:
undetectable
5dzkv-5wlnG:
undetectable		 5dzkh-5wlnG:
15.70
5dzkn-5wlnG:
15.70
5dzkv-5wlnG:
0.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		4 ILE A 231
ILE A 248
ARG A 467
LEU A 235
 None
 1.07A 5dzkh-5xhqA:
undetectable
5dzkn-5xhqA:
undetectable
5dzkv-5xhqA:
undetectable		 5dzkh-5xhqA:
18.54
5dzkn-5xhqA:
18.54
5dzkv-5xhqA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zba -

(-) 		no annotation 4 ILE B  95
ILE B 139
ARG B 137
LEU B  97
 None
 1.00A 5dzkh-5zbaB:
undetectable
5dzkn-5zbaB:
undetectable
5dzkv-5zbaB:
undetectable		 5dzkh-5zbaB:
undetectable
5dzkn-5zbaB:
undetectable
5dzkv-5zbaB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 4 ILE D 273
ILE D 256
ARG D 284
LEU D 289
 None
 1.13A 5dzkh-6cg0D:
undetectable
5dzkn-6cg0D:
undetectable
5dzkv-6cg0D:
undetectable		 5dzkh-6cg0D:
undetectable
5dzkn-6cg0D:
undetectable
5dzkv-6cg0D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cim V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 4 ILE B 273
ILE B 256
ARG B 284
LEU B 289
 None
 1.16A 5dzkh-6cimB:
undetectable
5dzkn-6cimB:
undetectable
5dzkv-6cimB:
undetectable		 5dzkh-6cimB:
undetectable
5dzkn-6cimB:
undetectable
5dzkv-6cimB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek4 PAXB

(Photorhabdus
luminescens) 		no annotation 4 ILE A  29
ILE A  50
ARG A 295
LEU A  32
 None
 1.14A 5dzkh-6ek4A:
undetectable
5dzkn-6ek4A:
undetectable
5dzkv-6ek4A:
undetectable		 5dzkh-6ek4A:
undetectable
5dzkn-6ek4A:
undetectable
5dzkv-6ek4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emz INT PROTEIN

(Enterococcus
faecalis) 		no annotation 4 ILE A 367
ILE A 272
ARG A 270
LEU A 354
 None
 1.26A 5dzkh-6emzA:
undetectable
5dzkn-6emzA:
undetectable
5dzkv-6emzA:
undetectable		 5dzkh-6emzA:
undetectable
5dzkn-6emzA:
undetectable
5dzkv-6emzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 4 ILE D 479
ILE D 386
ARG D 382
LEU D 481
 None
None
EDO  D 704 ( 4.7A)
None
 1.22A 5dzkh-6eq8D:
undetectable
5dzkn-6eq8D:
undetectable
5dzkv-6eq8D:
undetectable		 5dzkh-6eq8D:
undetectable
5dzkn-6eq8D:
undetectable
5dzkv-6eq8D:
undetectable