SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_U_BEZU801_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A 625
SER A 631
HIS A 632
LEU A 699
 None
 1.27A 5dzkg-1d5fA:
undetectable
5dzku-1d5fA:
undetectable		 5dzkg-1d5fA:
23.18
5dzku-1d5fA:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5w MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.25A 5dzkg-1e5wA:
undetectable
5dzku-1e5wA:
undetectable		 5dzkg-1e5wA:
21.01
5dzku-1e5wA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eco ERYTHROCRUORIN
(CARBONMONOXY)

(Chironomus
thummi) 		PF00042
(Globin) 		4 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.95A 5dzkg-1ecoA:
undetectable
5dzku-1ecoA:
undetectable		 5dzkg-1ecoA:
22.12
5dzku-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef1 MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.26A 5dzkg-1ef1A:
undetectable
5dzku-1ef1A:
undetectable		 5dzkg-1ef1A:
20.81
5dzku-1ef1A:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flk TNF RECEPTOR
ASSOCIATED FACTOR 3

(Homo sapiens) 		no annotation 4 SER A 378
ALA A 392
MET A 414
LEU A 354
 None
 1.04A 5dzkg-1flkA:
undetectable
5dzku-1flkA:
undetectable		 5dzkg-1flkA:
21.94
5dzku-1flkA:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6y PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Arabidopsis
thaliana) 		PF00639
(Rotamase) 		4 SER A  72
ALA A  73
HIS A  12
LEU A  14
 None
 1.08A 5dzkg-1j6yA:
undetectable
5dzku-1j6yA:
undetectable		 5dzkg-1j6yA:
23.15
5dzku-1j6yA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmk SURFACTIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		4 SER C  80
ALA C  81
HIS C 207
LEU C 129
 None
 1.27A 5dzkg-1jmkC:
1.7
5dzku-1jmkC:
undetectable		 5dzkg-1jmkC:
22.92
5dzku-1jmkC:
1.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzn GALACTOSE-SPECIFIC
LECTIN

(Crotalus atrox) 		PF00059
(Lectin_C) 		4 SER A  42
ALA A  41
HIS A  44
LEU A  13
 NA  A1139 (-2.9A)
None
None
None
 1.16A 5dzkg-1jznA:
undetectable
5dzku-1jznA:
undetectable		 5dzkg-1jznA:
18.02
5dzku-1jznA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		4 PHE B 166
ALA B 197
HIS B 193
LEU B 168
 None
 1.27A 5dzkg-1kwcB:
undetectable
5dzku-1kwcB:
undetectable		 5dzkg-1kwcB:
20.95
5dzku-1kwcB:
1.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 PHE A 305
SER A 310
HIS A 311
LEU A 307
 None
 0.94A 5dzkg-1muuA:
2.9
5dzku-1muuA:
undetectable		 5dzkg-1muuA:
18.88
5dzku-1muuA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A 663
ALA A 665
HIS A 670
LEU A 592
 None
 1.26A 5dzkg-1nd7A:
undetectable
5dzku-1nd7A:
undetectable		 5dzkg-1nd7A:
21.45
5dzku-1nd7A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 PHE A 291
SER A 297
ALA A 296
HIS A 362
 None
 1.31A 5dzkg-1p1mA:
3.6
5dzku-1p1mA:
undetectable		 5dzkg-1p1mA:
18.38
5dzku-1p1mA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 PHE A 354
SER A 314
ALA A 317
LEU A 356
 None
G24  A 462 ( 4.7A)
G24  A 462 ( 4.1A)
None
 1.27A 5dzkg-1q4xA:
undetectable
5dzku-1q4xA:
undetectable		 5dzkg-1q4xA:
21.25
5dzku-1q4xA:
1.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgo ANAEROBIC COBALAMIN
BIOSYNTHETIC COBALT
CHELATASE

(Salmonella
enterica) 		PF06180
(CbiK) 		4 SER A  32
ALA A  31
HIS A 253
LEU A   5
 None
 1.24A 5dzkg-1qgoA:
undetectable
5dzku-1qgoA:
undetectable		 5dzkg-1qgoA:
21.11
5dzku-1qgoA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		4 PHE A 379
ALA A 312
HIS A 296
LEU A 314
 None
 1.23A 5dzkg-1r76A:
undetectable
5dzku-1r76A:
undetectable		 5dzkg-1r76A:
21.20
5dzku-1r76A:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3i PROBABLE CYSTEINE
DESULFURASE

(Synechocystis
sp.) 		PF00266
(Aminotran_5) 		4 SER A 209
ALA A 210
HIS A 177
LEU A 225
 None
 1.30A 5dzkg-1t3iA:
undetectable
5dzku-1t3iA:
undetectable		 5dzkg-1t3iA:
18.37
5dzku-1t3iA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 SER A 268
ALA A 266
HIS A 536
MET A 570
 None
 1.06A 5dzkg-1we5A:
undetectable
5dzku-1we5A:
undetectable		 5dzkg-1we5A:
13.64
5dzku-1we5A:
0.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		4 PHE A 213
SER A 219
ALA A 218
HIS A 220
 None
 0.95A 5dzkg-1xkqA:
undetectable
5dzku-1xkqA:
undetectable		 5dzkg-1xkqA:
22.41
5dzku-1xkqA:
1.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		4 PHE A 159
SER A 205
HIS A 187
LEU A 161
 None
 1.24A 5dzkg-1zq9A:
undetectable
5dzku-1zq9A:
undetectable		 5dzkg-1zq9A:
23.24
5dzku-1zq9A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgk GLUTAMATE
DECARBOXYLASE BETA

(Escherichia
coli) 		PF00282
(Pyridoxal_deC) 		4 PHE A  63
SER A 273
ALA A 245
HIS A 275
 PLP  A1500 ( 4.7A)
PLP  A1500 (-2.8A)
PLP  A1500 (-3.4A)
PLP  A1500 (-3.8A)
 1.19A 5dzkg-2dgkA:
undetectable
5dzku-2dgkA:
undetectable		 5dzkg-2dgkA:
20.62
5dzku-2dgkA:
0.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebb PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE

(Geobacillus
kaustophilus) 		PF01329
(Pterin_4a) 		4 SER A  73
ALA A  76
HIS A  56
LEU A  79
 None
 1.32A 5dzkg-2ebbA:
undetectable
5dzku-2ebbA:
undetectable		 5dzkg-2ebbA:
18.22
5dzku-2ebbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 PHE A 260
SER A 226
ALA A 227
HIS A 471
 None
TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
 1.28A 5dzkg-2fj0A:
2.5
5dzku-2fj0A:
undetectable		 5dzkg-2fj0A:
17.60
5dzku-2fj0A:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		4 SER A 329
ALA A 332
HIS A 327
MET A   9
 None
 1.20A 5dzkg-2greA:
undetectable
5dzku-2greA:
undetectable		 5dzkg-2greA:
20.80
5dzku-2greA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Homo sapiens) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 PHE A  61
SER A 114
ALA A  57
LEU A 110
 None
 1.33A 5dzkg-2jbmA:
2.7
5dzku-2jbmA:
undetectable		 5dzkg-2jbmA:
22.07
5dzku-2jbmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8y PROTEIN RCSF

(Escherichia
coli) 		PF16358
(RcsF) 		4 SER A 127
ALA A 128
HIS A 107
MET A  92
 None
 1.27A 5dzkg-2l8yA:
undetectable
5dzku-2l8yA:
undetectable		 5dzkg-2l8yA:
20.10
5dzku-2l8yA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 PHE A  94
ALA A 135
HIS A  90
LEU A 126
 None
 1.29A 5dzkg-2o7rA:
3.0
5dzku-2o7rA:
undetectable		 5dzkg-2o7rA:
24.93
5dzku-2o7rA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A 361
ALA A 351
HIS A 414
LEU A 213
 None
 1.26A 5dzkg-2qaeA:
undetectable
5dzku-2qaeA:
undetectable		 5dzkg-2qaeA:
21.06
5dzku-2qaeA:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PHE A 403
SER A 495
ALA A 498
HIS A 650
LEU A 405
 None
 1.43A 5dzkg-2wskA:
undetectable
5dzku-2wskA:
undetectable		 5dzkg-2wskA:
16.17
5dzku-2wskA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 PHE A 418
ALA A 420
HIS A 395
MET A 432
 None
 1.28A 5dzkg-2wtzA:
1.5
5dzku-2wtzA:
undetectable		 5dzkg-2wtzA:
17.49
5dzku-2wtzA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y1b PUTATIVE OUTER
MEMBRANE PROTEIN,
SIGNAL

(Escherichia
coli) 		PF16358
(RcsF) 		4 SER A 127
ALA A 128
HIS A 107
MET A  92
 None
None
I3C  A1133 (-3.6A)
None
 1.03A 5dzkg-2y1bA:
undetectable
5dzku-2y1bA:
undetectable		 5dzkg-2y1bA:
20.72
5dzku-2y1bA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		4 PHE A 148
SER A  46
MET A 145
LEU A 149
 None
 1.10A 5dzkg-3clwA:
1.5
5dzku-3clwA:
undetectable		 5dzkg-3clwA:
18.55
5dzku-3clwA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 PHE A 367
SER A 269
ALA A 295
LEU A 369
 None
 1.02A 5dzkg-3goaA:
undetectable
5dzku-3goaA:
undetectable		 5dzkg-3goaA:
20.89
5dzku-3goaA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		4 PHE A  63
SER A 274
ALA A 246
HIS A 276
 None
LLP  A 277 ( 2.8A)
LLP  A 277 ( 3.3A)
LLP  A 277 ( 3.8A)
 1.15A 5dzkg-3hbxA:
undetectable
5dzku-3hbxA:
undetectable		 5dzkg-3hbxA:
16.44
5dzku-3hbxA:
0.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 SER A 201
ALA A 204
MET A 282
LEU A 270
 None
 1.14A 5dzkg-3hf1A:
undetectable
5dzku-3hf1A:
undetectable		 5dzkg-3hf1A:
20.51
5dzku-3hf1A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 PHE A  48
SER A 152
ALA A 153
HIS A 348
 None
 1.20A 5dzkg-3i1iA:
undetectable
5dzku-3i1iA:
undetectable		 5dzkg-3i1iA:
20.63
5dzku-3i1iA:
0.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 PHE W 632
ALA W 636
HIS W 638
LEU W 634
 None
 1.28A 5dzkg-3iylW:
undetectable
5dzku-3iylW:
undetectable		 5dzkg-3iylW:
10.38
5dzku-3iylW:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 SER A 456
ALA A 457
HIS A 156
LEU A 152
 None
None
None
SIN  A 504 (-4.8A)
 1.13A 5dzkg-3ju8A:
undetectable
5dzku-3ju8A:
undetectable		 5dzkg-3ju8A:
17.72
5dzku-3ju8A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Streptococcus
pyogenes) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A  40
SER A  72
ALA A  38
HIS A  74
 None
 1.30A 5dzkg-3lgxA:
undetectable
5dzku-3lgxA:
undetectable		 5dzkg-3lgxA:
18.41
5dzku-3lgxA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		4 PHE A 177
SER A 158
ALA A 157
HIS A 139
 None
 1.31A 5dzkg-3mkqA:
undetectable
5dzku-3mkqA:
undetectable		 5dzkg-3mkqA:
14.41
5dzku-3mkqA:
0.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 PHE A 189
SER A 186
ALA A 187
HIS A 539
 None
 1.24A 5dzkg-3ngoA:
undetectable
5dzku-3ngoA:
undetectable		 5dzkg-3ngoA:
19.36
5dzku-3ngoA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC

(Zea mays) 		PF03055
(RPE65) 		4 PHE A 102
SER A 222
ALA A 225
HIS A 221
 None
 1.18A 5dzkg-3npeA:
undetectable
5dzku-3npeA:
undetectable		 5dzkg-3npeA:
17.39
5dzku-3npeA:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocr CLASS II
ALDOLASE/ADDUCIN
DOMAIN PROTEIN

(Pseudomonas
savastanoi) 		PF00596
(Aldolase_II) 		4 SER A  57
ALA A  58
HIS A 110
LEU A 124
 None
 1.18A 5dzkg-3ocrA:
undetectable
5dzku-3ocrA:
undetectable		 5dzkg-3ocrA:
22.76
5dzku-3ocrA:
1.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		4 PHE A 248
SER A 144
ALA A 143
HIS A 101
 None
NAD  A1385 ( 4.9A)
None
None
 1.20A 5dzkg-3ox4A:
undetectable
5dzku-3ox4A:
undetectable		 5dzkg-3ox4A:
21.79
5dzku-3ox4A:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py6 BETA-LACTAMASE-LIKE

(Brucella
abortus) 		PF12706
(Lactamase_B_2) 		4 PHE A 220
SER A 218
HIS A 170
LEU A 211
 None
5GP  A 303 ( 4.3A)
MN  A 301 ( 3.4A)
None
 1.24A 5dzkg-3py6A:
undetectable
5dzku-3py6A:
undetectable		 5dzkg-3py6A:
23.96
5dzku-3py6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh4 ESTERASE LIPW

(Mycobacterium
marinum) 		PF07859
(Abhydrolase_3) 		4 PHE A  92
ALA A 131
HIS A  88
LEU A 122
 None
 1.22A 5dzkg-3qh4A:
2.4
5dzku-3qh4A:
undetectable		 5dzkg-3qh4A:
21.88
5dzku-3qh4A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 PHE A 488
SER A 461
ALA A 460
LEU A 164
 None
 1.27A 5dzkg-3tk3A:
undetectable
5dzku-3tk3A:
undetectable		 5dzkg-3tk3A:
19.24
5dzku-3tk3A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		4 PHE A  92
SER A  72
ALA A  69
LEU A 792
 None
 0.99A 5dzkg-3tlmA:
undetectable
5dzku-3tlmA:
undetectable		 5dzkg-3tlmA:
12.23
5dzku-3tlmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Coxiella
burnetii) 		PF01590
(GAF) 		4 SER A 134
ALA A  90
HIS A 110
LEU A  94
 None
 1.21A 5dzkg-3trcA:
undetectable
5dzku-3trcA:
undetectable		 5dzkg-3trcA:
23.89
5dzku-3trcA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		4 PHE A 229
SER A 194
ALA A 191
LEU A 207
 None
 1.29A 5dzkg-3us8A:
undetectable
5dzku-3us8A:
undetectable		 5dzkg-3us8A:
19.08
5dzku-3us8A:
0.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP

(Bacillus
subtilis) 		PF00494
(SQS_PSY) 		4 PHE A  87
SER A  49
ALA A  46
LEU A  83
 None
 1.28A 5dzkg-3we9A:
undetectable
5dzku-3we9A:
undetectable		 5dzkg-3we9A:
22.77
5dzku-3we9A:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz0 RIBONUCLEASE P
PROTEIN COMPONENT 2

(Thermococcus
kodakarensis) 		no annotation 4 PHE C  82
SER C  44
ALA C  45
LEU C  87
 None
 1.18A 5dzkg-3wz0C:
undetectable
5dzku-3wz0C:
undetectable		 5dzkg-3wz0C:
23.70
5dzku-3wz0C:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PHE A 306
ALA A 332
HIS A 319
LEU A 334
 None
None
5FX  A1531 ( 4.5A)
None
 1.26A 5dzkg-4bc5A:
undetectable
5dzku-4bc5A:
undetectable		 5dzkg-4bc5A:
17.94
5dzku-4bc5A:
0.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		4 PHE A 302
SER A 308
ALA A 307
LEU A 304
 None
 0.96A 5dzkg-4bqiA:
1.7
5dzku-4bqiA:
undetectable		 5dzkg-4bqiA:
14.15
5dzku-4bqiA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00043
(GST_C) 		4 PHE A  69
SER A  63
ALA A  64
LEU A 143
 None
 1.31A 5dzkg-4bvxA:
undetectable
5dzku-4bvxA:
undetectable		 5dzkg-4bvxA:
21.46
5dzku-4bvxA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 PHE A 121
ALA A 123
MET A  66
LEU A 119
 None
 1.26A 5dzkg-4byfA:
undetectable
5dzku-4byfA:
undetectable		 5dzkg-4byfA:
15.66
5dzku-4byfA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 PHE A 110
SER A  59
ALA A 104
LEU A 111
 None
 1.28A 5dzkg-4fn7A:
13.9
5dzku-4fn7A:
undetectable		 5dzkg-4fn7A:
26.48
5dzku-4fn7A:
1.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40) 		5 PHE B 281
SER B 263
ALA B 262
HIS B 244
LEU B 273
 None
 1.38A 5dzkg-4g56B:
undetectable
5dzku-4g56B:
undetectable		 5dzkg-4g56B:
21.88
5dzku-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h17 HYDROLASE,
ISOCHORISMATASE
FAMILY

(Pseudomonas
putida) 		PF00857
(Isochorismatase) 		4 SER A 157
ALA A 156
HIS A 175
LEU A 152
 None
None
EDO  A 206 ( 4.1A)
None
 1.12A 5dzkg-4h17A:
undetectable
5dzku-4h17A:
undetectable		 5dzkg-4h17A:
24.27
5dzku-4h17A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		4 PHE A 341
SER A 429
ALA A 432
LEU A 442
 None
 1.29A 5dzkg-4j9uA:
undetectable
5dzku-4j9uA:
undetectable		 5dzkg-4j9uA:
16.63
5dzku-4j9uA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		4 PHE A 121
SER A 216
ALA A 213
LEU A 119
 None
 1.25A 5dzkg-4jreA:
undetectable
5dzku-4jreA:
undetectable		 5dzkg-4jreA:
19.43
5dzku-4jreA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jsb ENOYL-COA HYDRATASE

(Thermobifida
fusca) 		PF00378
(ECH_1) 		4 PHE A 138
SER A  71
ALA A 133
LEU A 140
 None
 1.30A 5dzkg-4jsbA:
11.5
5dzku-4jsbA:
undetectable		 5dzkg-4jsbA:
23.18
5dzku-4jsbA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k00 1,4-DIHYDROXY-2-NAPH
THOYL-COA HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF03061
(4HBT) 		4 PHE A  89
SER A  85
ALA A  84
HIS A  87
 None
 1.29A 5dzkg-4k00A:
undetectable
5dzku-4k00A:
undetectable		 5dzkg-4k00A:
20.47
5dzku-4k00A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmh SUPPRESSOR OF FUSED
HOMOLOG

(Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		4 PHE A 373
ALA A 274
HIS A 370
LEU A 474
 None
 1.18A 5dzkg-4kmhA:
undetectable
5dzku-4kmhA:
undetectable		 5dzkg-4kmhA:
18.80
5dzku-4kmhA:
1.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		4 PHE A 187
SER A 199
ALA A 198
LEU A 196
 None
 1.11A 5dzkg-4lz6A:
undetectable
5dzku-4lz6A:
undetectable		 5dzkg-4lz6A:
18.22
5dzku-4lz6A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM

(Caldanaerobacter
subterraneus) 		PF01891
(CbiM) 		4 PHE A 111
SER A  84
ALA A 114
LEU A  24
 None
None
None
HEZ  A 309 ( 4.2A)
 1.10A 5dzkg-4m5bA:
undetectable
5dzku-4m5bA:
undetectable		 5dzkg-4m5bA:
22.22
5dzku-4m5bA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oiy PROTEIN TRANSPORT
PROTEIN SEC7

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		4 PHE A1002
SER A 958
MET A 975
LEU A 998
 None
 1.21A 5dzkg-4oiyA:
undetectable
5dzku-4oiyA:
undetectable		 5dzkg-4oiyA:
24.89
5dzku-4oiyA:
4.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2

(Mycobacterium
tuberculosis) 		PF00574
(CLP_protease) 		5 PHE A  83
SER A 110
ALA A 111
HIS A 135
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 ( 2.9A)
 0.49A 5dzkg-4u0gA:
27.4
5dzku-4u0gA:
undetectable		 5dzkg-4u0gA:
100.00
5dzku-4u0gA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		4 PHE A 231
SER A 528
ALA A 530
LEU A 595
 None
 1.32A 5dzkg-4u33A:
2.8
5dzku-4u33A:
undetectable		 5dzkg-4u33A:
13.12
5dzku-4u33A:
1.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		4 SER A 300
ALA A 309
HIS A 320
LEU A  32
 None
 1.24A 5dzkg-4u9oA:
undetectable
5dzku-4u9oA:
undetectable		 5dzkg-4u9oA:
22.04
5dzku-4u9oA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvj COHESIN SUBUNIT SCC3

(Saccharomyces
cerevisiae) 		no annotation 4 SER A 692
ALA A 691
MET A 746
LEU A 688
 None
 0.88A 5dzkg-4uvjA:
undetectable
5dzku-4uvjA:
undetectable		 5dzkg-4uvjA:
20.15
5dzku-4uvjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w79 PROTEIN N-TERMINAL
GLUTAMINE
AMIDOHYDROLASE

(Homo sapiens) 		PF09764
(Nt_Gln_amidase) 		4 PHE A  94
SER A  15
ALA A  14
LEU A  84
 None
 1.05A 5dzkg-4w79A:
undetectable
5dzku-4w79A:
undetectable		 5dzkg-4w79A:
19.91
5dzku-4w79A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 SER A 164
ALA A 165
HIS A 291
MET A 218
 None
 1.22A 5dzkg-4wy8A:
2.4
5dzku-4wy8A:
undetectable		 5dzkg-4wy8A:
22.94
5dzku-4wy8A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A 611
ALA A 613
HIS A 618
LEU A 540
 None
 1.20A 5dzkg-4y07A:
undetectable
5dzku-4y07A:
undetectable		 5dzkg-4y07A:
20.95
5dzku-4y07A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 PHE A 351
SER A 382
ALA A 383
LEU A 355
 None
 1.32A 5dzkg-4ynnA:
undetectable
5dzku-4ynnA:
undetectable		 5dzkg-4ynnA:
20.85
5dzku-4ynnA:
0.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		4 SER A 159
ALA A 160
HIS A 283
MET A 213
 None
 1.23A 5dzkg-4ypvA:
2.7
5dzku-4ypvA:
undetectable		 5dzkg-4ypvA:
22.35
5dzku-4ypvA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 SER A  76
ALA A 358
HIS A 320
LEU A 131
 None
 1.28A 5dzkg-4yzoA:
undetectable
5dzku-4yzoA:
undetectable		 5dzkg-4yzoA:
19.79
5dzku-4yzoA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 PHE A 510
SER A 519
ALA A 511
HIS A 453
 None
 1.29A 5dzkg-5cslA:
10.3
5dzku-5cslA:
undetectable		 5dzkg-5cslA:
6.60
5dzku-5cslA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156

(uncultured
organism) 		no annotation 4 SER A 232
ALA A 261
HIS A 231
LEU A 352
 None
 1.04A 5dzkg-5d8mA:
undetectable
5dzku-5d8mA:
undetectable		 5dzkg-5d8mA:
22.62
5dzku-5d8mA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyr VIRULENCE-ASSOCIATED
PROTEIN D

(Xylella
fastidiosa) 		PF09827
(CRISPR_Cas2) 		4 PHE A  92
ALA A  90
HIS A  37
LEU A  84
 None
 1.15A 5dzkg-5dyrA:
2.8
5dzku-5dyrA:
undetectable		 5dzkg-5dyrA:
22.88
5dzku-5dyrA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eeb ALDEHYDE
DEHYDROGENASE

(Pyrobaculum
ferrireducens) 		PF00171
(Aldedh) 		4 PHE A 277
SER A 289
ALA A 290
LEU A 280
 None
 1.30A 5dzkg-5eebA:
undetectable
5dzku-5eebA:
undetectable		 5dzkg-5eebA:
18.33
5dzku-5eebA:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		4 PHE A 171
SER A 122
ALA A 125
LEU A 169
 MPG  A 617 ( 4.5A)
None
None
5TR  A 681 ( 4.3A)
 1.06A 5dzkg-5f15A:
undetectable
5dzku-5f15A:
undetectable		 5dzkg-5f15A:
16.67
5dzku-5f15A:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 4 PHE C  65
SER C 276
ALA C 248
HIS C 278
 None
PLP  C 501 (-2.7A)
PLP  C 501 (-3.1A)
PLP  C 501 (-3.8A)
 1.13A 5dzkg-5gp4C:
undetectable
5dzku-5gp4C:
undetectable		 5dzkg-5gp4C:
17.12
5dzku-5gp4C:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 SER B 337
ALA B 334
HIS B 341
LEU B 732
 None
 1.05A 5dzkg-5iz5B:
undetectable
5dzku-5iz5B:
undetectable		 5dzkg-5iz5B:
13.54
5dzku-5iz5B:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mal LIPASE

(Streptomyces
rimosus) 		PF13472
(Lipase_GDSL_2) 		4 SER A  41
ALA A  40
HIS A  42
LEU A 227
 None
 1.02A 5dzkg-5malA:
undetectable
5dzku-5malA:
undetectable		 5dzkg-5malA:
23.20
5dzku-5malA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF04616
(Glyco_hydro_43) 		4 PHE A 169
ALA A 176
MET A 236
LEU A 178
 None
 1.31A 5dzkg-5msxA:
undetectable
5dzku-5msxA:
undetectable		 5dzkg-5msxA:
17.74
5dzku-5msxA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 PHE A 560
SER A 623
ALA A 624
HIS A 631
 None
 1.26A 5dzkg-5n4lA:
undetectable
5dzku-5n4lA:
undetectable		 5dzkg-5n4lA:
undetectable
5dzku-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR

(Homo sapiens) 		PF00002
(7tm_2)
PF02793
(HRM) 		4 PHE A 187
SER A 193
ALA A 191
LEU A 189
 None
 1.26A 5dzkg-5nx2A:
undetectable
5dzku-5nx2A:
undetectable		 5dzkg-5nx2A:
21.43
5dzku-5nx2A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td3 CATECHOL
1,2-DIOXYGENASE

(Burkholderia
vietnamiensis) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 PHE A 299
SER A 242
ALA A 162
HIS A 245
 None
 1.26A 5dzkg-5td3A:
undetectable
5dzku-5td3A:
undetectable		 5dzkg-5td3A:
22.92
5dzku-5td3A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00397
(WW)
PF00632
(HECT) 		4 PHE A 611
ALA A 613
HIS A 618
LEU A 540
 None
 1.20A 5dzkg-5tj7A:
undetectable
5dzku-5tj7A:
undetectable		 5dzkg-5tj7A:
19.46
5dzku-5tj7A:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		4 SER A 458
ALA A 459
HIS A 159
LEU A 155
 8YP  A 507 (-2.3A)
8YP  A 507 (-2.8A)
8YP  A 507 (-3.1A)
8YP  A 507 (-3.8A)
 1.23A 5dzkg-5u0lA:
undetectable
5dzku-5u0lA:
undetectable		 5dzkg-5u0lA:
17.81
5dzku-5u0lA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 PHE A 724
SER A 730
ALA A 729
HIS A 818
 None
 0.84A 5dzkg-5um6A:
undetectable
5dzku-5um6A:
undetectable		 5dzkg-5um6A:
11.46
5dzku-5um6A:
0.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 4 SER A 146
ALA A 208
HIS A 147
LEU A 231
 None
 1.22A 5dzkg-5uqrA:
undetectable
5dzku-5uqrA:
undetectable		 5dzkg-5uqrA:
undetectable
5dzku-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		4 SER f 409
ALA f 410
MET f 416
LEU f 372
 None
 1.21A 5dzkg-5vhif:
undetectable
5dzku-5vhif:
undetectable		 5dzkg-5vhif:
13.63
5dzku-5vhif:
1.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 PHE A1116
SER A1105
ALA A1112
LEU A1081
 None
 1.03A 5dzkg-5vkqA:
undetectable
5dzku-5vkqA:
undetectable		 5dzkg-5vkqA:
8.08
5dzku-5vkqA:
1.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus) 		no annotation 4 PHE B 188
SER B  99
ALA B  96
LEU B  87
 None
 1.28A 5dzkg-5x1yB:
undetectable
5dzku-5x1yB:
undetectable		 5dzkg-5x1yB:
17.98
5dzku-5x1yB:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 SER H  98
ALA H 101
HIS H  34
LEU L 100
 None
 1.19A 5dzkg-6aq7H:
undetectable
5dzku-6aq7H:
undetectable		 5dzkg-6aq7H:
undetectable
5dzku-6aq7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 4 PHE B 291
SER B 273
ALA B 272
HIS B 254
 None
 1.14A 5dzkg-6ckcB:
undetectable
5dzku-6ckcB:
undetectable		 5dzkg-6ckcB:
undetectable
5dzku-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 4 PHE A 190
ALA A 193
MET A  46
LEU A 191
 None
 1.14A 5dzkg-6exsA:
undetectable
5dzku-6exsA:
undetectable		 5dzkg-6exsA:
undetectable
5dzku-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2d FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIP
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIR

(Salmonella
enterica;
Salmonella
enterica) 		no annotation
no annotation 		4 SER F  34
HIS F 143
MET F 134
LEU A 179
 None
 1.04A 5dzkg-6f2dF:
undetectable
5dzku-6f2dF:
undetectable		 5dzkg-6f2dF:
undetectable
5dzku-6f2dF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffl MALTOSE/MALTODEXTRIN
TRANSPORT PERMEASE
HOMOLOGUE

(Bdellovibrio
bacteriovorus) 		no annotation 4 SER A 331
ALA A 332
HIS A 115
LEU A 310
 None
 1.19A 5dzkg-6fflA:
undetectable
5dzku-6fflA:
undetectable		 5dzkg-6fflA:
undetectable
5dzku-6fflA:
undetectable