SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_T_BEZT801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		4 SER A 209
ALA A 210
HIS A 449
LEU A 302
 None
 1.13A 5dzkF-1crlA:
0.3
5dzkT-1crlA:
undetectable		 5dzkF-1crlA:
17.18
5dzkT-1crlA:
0.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		4 ALA A 259
HIS A 234
LEU A 214
LEU A 215
 None
 1.03A 5dzkF-1dgmA:
2.0
5dzkT-1dgmA:
undetectable		 5dzkF-1dgmA:
21.27
5dzkT-1dgmA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 279
ALA A 278
HIS A 244
LEU A 142
 None
None
COA  A1350 (-4.4A)
None
 1.02A 5dzkF-1eblA:
undetectable
5dzkT-1eblA:
undetectable		 5dzkF-1eblA:
21.18
5dzkT-1eblA:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eco ERYTHROCRUORIN
(CARBONMONOXY)

(Chironomus
thummi) 		PF00042
(Globin) 		4 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.95A 5dzkF-1ecoA:
undetectable
5dzkT-1ecoA:
undetectable		 5dzkF-1ecoA:
22.12
5dzkT-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 SER A  56
HIS A 199
PRO A 235
LEU A 237
 None
 1.14A 5dzkF-1ezvA:
0.0
5dzkT-1ezvA:
undetectable		 5dzkF-1ezvA:
18.79
5dzkT-1ezvA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		4 SER A 174
ALA A 175
HIS A 286
PRO A 178
 None
 1.07A 5dzkF-1gzvA:
0.5
5dzkT-1gzvA:
undetectable		 5dzkF-1gzvA:
16.52
5dzkT-1gzvA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgc BACTERIOFERRITIN

(Rhodobacter
capsulatus) 		PF00210
(Ferritin) 		4 ALA A  60
PRO A  69
LEU A  11
LEU A  15
 None
 1.20A 5dzkF-1jgcA:
undetectable
5dzkT-1jgcA:
undetectable		 5dzkF-1jgcA:
22.07
5dzkT-1jgcA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzn GALACTOSE-SPECIFIC
LECTIN

(Crotalus atrox) 		PF00059
(Lectin_C) 		4 SER A  42
ALA A  41
HIS A  44
LEU A  13
 NA  A1139 (-2.9A)
None
None
None
 1.15A 5dzkF-1jznA:
undetectable
5dzkT-1jznA:
undetectable		 5dzkF-1jznA:
18.02
5dzkT-1jznA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 SER A 248
ALA A 249
HIS A 197
PRO A 184
 None
 1.18A 5dzkF-1l5jA:
0.6
5dzkT-1l5jA:
undetectable		 5dzkF-1l5jA:
13.89
5dzkT-1l5jA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 PHE A 612
ALA A 476
HIS A 555
LEU A 613
 None
 1.00A 5dzkF-1llaA:
undetectable
5dzkT-1llaA:
undetectable		 5dzkF-1llaA:
15.40
5dzkT-1llaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Mycobacterium
tuberculosis) 		PF01625
(PMSR) 		4 SER A  94
ALA A  95
HIS A  76
LEU A  69
 None
 1.21A 5dzkF-1nwaA:
0.0
5dzkT-1nwaA:
undetectable		 5dzkF-1nwaA:
20.08
5dzkT-1nwaA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 SER A 103
ALA A  76
HIS A 180
LEU A  73
 None
 0.99A 5dzkF-1pgpA:
undetectable
5dzkT-1pgpA:
undetectable		 5dzkF-1pgpA:
17.63
5dzkT-1pgpA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		4 PHE A  28
SER A 206
PRO A  93
LEU A  23
 None
 0.95A 5dzkF-1u9cA:
undetectable
5dzkT-1u9cA:
undetectable		 5dzkF-1u9cA:
25.70
5dzkT-1u9cA:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y30 HYPOTHETICAL PROTEIN
RV1155

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		4 ALA A  82
PRO A 135
LEU A  45
LEU A  46
 None
 1.18A 5dzkF-1y30A:
undetectable
5dzkT-1y30A:
undetectable		 5dzkF-1y30A:
21.30
5dzkT-1y30A:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE

(Moorella
thermoacetica) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 SER A 152
ALA A 144
HIS A  81
LEU A 200
 None
None
FEO  A 501 (-3.3A)
None
 1.01A 5dzkF-1ycgA:
undetectable
5dzkT-1ycgA:
undetectable		 5dzkF-1ycgA:
22.19
5dzkT-1ycgA:
0.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 ALA A  47
HIS A 303
PRO A 305
LEU A 277
 None
 1.10A 5dzkF-2cy7A:
undetectable
5dzkT-2cy7A:
undetectable		 5dzkF-2cy7A:
20.33
5dzkT-2cy7A:
0.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		4 PHE A 357
PRO A 363
LEU A 359
LEU A 356
 None
 1.11A 5dzkF-2dh3A:
2.4
5dzkT-2dh3A:
undetectable		 5dzkF-2dh3A:
19.39
5dzkT-2dh3A:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		4 PHE A 159
SER A 176
LEU A 129
LEU A 158
 None
 1.07A 5dzkF-2dy0A:
undetectable
5dzkT-2dy0A:
undetectable		 5dzkF-2dy0A:
24.43
5dzkT-2dy0A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8g HYPOTHETICAL PROTEIN
PH0536

(Pyrococcus
horikoshii) 		PF01588
(tRNA_bind) 		4 SER A  16
ALA A  13
MET A  45
LEU A 118
 None
 1.20A 5dzkF-2e8gA:
undetectable
5dzkT-2e8gA:
undetectable		 5dzkF-2e8gA:
20.73
5dzkT-2e8gA:
1.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 SER A 226
ALA A 227
HIS A 471
LEU A 313
 TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
TFC  A 600 (-4.2A)
 1.09A 5dzkF-2fj0A:
2.5
5dzkT-2fj0A:
undetectable		 5dzkF-2fj0A:
17.60
5dzkT-2fj0A:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hky RIBONUCLEASE 7

(Homo sapiens) 		PF00074
(RnaseA) 		4 PHE A 117
SER A   7
PRO A 121
LEU A 119
 None
 0.80A 5dzkF-2hkyA:
undetectable
5dzkT-2hkyA:
undetectable		 5dzkF-2hkyA:
17.92
5dzkT-2hkyA:
1.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7h STRESS-INDUCED
PROTEIN SAM22

(Glycine max) 		PF00407
(Bet_v_1) 		4 ALA A  14
PRO A  12
LEU A 150
LEU A 151
 None
 1.14A 5dzkF-2k7hA:
undetectable
5dzkT-2k7hA:
undetectable		 5dzkF-2k7hA:
21.78
5dzkT-2k7hA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9r BETA-GLUCOSIDASE B

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		4 ALA A 252
PRO A 289
LEU A 293
LEU A 350
 None
 1.02A 5dzkF-2o9rA:
1.6
5dzkT-2o9rA:
undetectable		 5dzkF-2o9rA:
19.64
5dzkT-2o9rA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 SER A 103
ALA A  76
HIS A 179
LEU A  73
 None
 0.94A 5dzkF-2p4qA:
undetectable
5dzkT-2p4qA:
undetectable		 5dzkF-2p4qA:
17.73
5dzkT-2p4qA:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		4 ALA A 335
PRO A 153
LEU A 366
LEU A 365
 None
 1.11A 5dzkF-2pgeA:
2.2
5dzkT-2pgeA:
undetectable		 5dzkF-2pgeA:
22.65
5dzkT-2pgeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 PHE A 476
ALA A 556
PRO A 541
LEU A 539
 None
 1.14A 5dzkF-2vycA:
undetectable
5dzkT-2vycA:
undetectable		 5dzkF-2vycA:
14.97
5dzkT-2vycA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 SER A 142
ALA A 453
LEU A 275
LEU A 272
 None
 1.20A 5dzkF-2xr1A:
undetectable
5dzkT-2xr1A:
undetectable		 5dzkF-2xr1A:
15.70
5dzkT-2xr1A:
0.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 SER A 141
ALA A 453
LEU A 275
LEU A 272
 None
 1.18A 5dzkF-2ycbA:
undetectable
5dzkT-2ycbA:
undetectable		 5dzkF-2ycbA:
15.43
5dzkT-2ycbA:
0.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 ALA A 377
HIS A 379
PRO A 449
LEU A 451
 None
 1.14A 5dzkF-2yr5A:
2.0
5dzkT-2yr5A:
undetectable		 5dzkF-2yr5A:
16.84
5dzkT-2yr5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		4 ALA A 400
PRO A 397
LEU A 393
LEU A 407
 None
 1.06A 5dzkF-2zblA:
undetectable
5dzkT-2zblA:
undetectable		 5dzkF-2zblA:
19.90
5dzkT-2zblA:
1.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii) 		PF00118
(Cpn60_TCP1) 		4 PHE B 281
ALA B 301
LEU B 231
LEU B 230
 None
 1.19A 5dzkF-3aq1B:
2.0
5dzkT-3aq1B:
undetectable		 5dzkF-3aq1B:
18.84
5dzkT-3aq1B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		4 PHE A 546
ALA A 541
LEU A  22
LEU A  26
 None
None
BOG  A 806 (-4.7A)
None
 1.20A 5dzkF-3ayfA:
undetectable
5dzkT-3ayfA:
undetectable		 5dzkF-3ayfA:
14.08
5dzkT-3ayfA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn7 FERREDOXIN-LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF07876
(Dabb) 		4 PHE A  82
ALA A  28
LEU A  78
LEU A  79
 ACT  A 102 (-4.8A)
None
None
None
 1.08A 5dzkF-3bn7A:
undetectable
5dzkT-3bn7A:
undetectable		 5dzkF-3bn7A:
21.60
5dzkT-3bn7A:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ

(Vibrio
vulnificus) 		PF11612
(T2SSJ) 		4 PHE B  91
ALA B  59
LEU B  74
LEU B  75
 None
 0.91A 5dzkF-3cfiB:
undetectable
5dzkT-3cfiB:
undetectable		 5dzkF-3cfiB:
19.91
5dzkT-3cfiB:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		no annotation 4 PHE A 119
ALA A 114
PRO A  77
LEU A 191
 None
 1.07A 5dzkF-3cjiA:
undetectable
5dzkT-3cjiA:
undetectable		 5dzkF-3cjiA:
23.21
5dzkT-3cjiA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed0 (3R)-HYDROXYMYRISTOY
L-ACYL CARRIER
PROTEIN DEHYDRATASE

(Helicobacter
pylori) 		PF07977
(FabA) 		4 PHE A  80
ALA A  44
LEU A 123
LEU A  81
 None
 1.20A 5dzkF-3ed0A:
undetectable
5dzkT-3ed0A:
undetectable		 5dzkF-3ed0A:
23.08
5dzkT-3ed0A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR

(Shewanella
oneidensis) 		PF02661
(Fic)
PF13784
(Fic_N) 		4 ALA A 196
PRO A 199
LEU A 167
LEU A 168
 PGE  A 373 ( 4.1A)
None
None
None
 0.77A 5dzkF-3eqxA:
undetectable
5dzkT-3eqxA:
undetectable		 5dzkF-3eqxA:
18.85
5dzkT-3eqxA:
0.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 300
ALA A 299
HIS A 265
LEU A 183
 None
 1.05A 5dzkF-3fk5A:
undetectable
5dzkT-3fk5A:
undetectable		 5dzkF-3fk5A:
21.83
5dzkT-3fk5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 PHE A  48
SER A 152
ALA A 153
HIS A 348
 None
 1.21A 5dzkF-3i1iA:
undetectable
5dzkT-3i1iA:
undetectable		 5dzkF-3i1iA:
20.63
5dzkT-3i1iA:
0.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		4 PHE A 224
SER A 266
ALA A 267
LEU A 299
 None
 1.18A 5dzkF-3kd6A:
undetectable
5dzkT-3kd6A:
undetectable		 5dzkF-3kd6A:
22.44
5dzkT-3kd6A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 SER B 148
HIS B 133
LEU B  61
LEU B  62
 None
 1.16A 5dzkF-3mm5B:
undetectable
5dzkT-3mm5B:
undetectable		 5dzkF-3mm5B:
18.45
5dzkT-3mm5B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocr CLASS II
ALDOLASE/ADDUCIN
DOMAIN PROTEIN

(Pseudomonas
savastanoi) 		PF00596
(Aldolase_II) 		4 SER A  57
ALA A  58
HIS A 110
LEU A 124
 None
 1.14A 5dzkF-3ocrA:
undetectable
5dzkT-3ocrA:
undetectable		 5dzkF-3ocrA:
22.76
5dzkT-3ocrA:
1.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 130
MET A 256
LEU A 191
LEU A 192
 None
 1.05A 5dzkF-3oukA:
undetectable
5dzkT-3oukA:
undetectable		 5dzkF-3oukA:
23.02
5dzkT-3oukA:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		4 PHE A 248
SER A 144
ALA A 143
HIS A 101
 None
NAD  A1385 ( 4.9A)
None
None
 1.20A 5dzkF-3ox4A:
undetectable
5dzkT-3ox4A:
undetectable		 5dzkF-3ox4A:
21.79
5dzkT-3ox4A:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rms UNCHARACTERIZED
PROTEIN

(Saccharomonospora
viridis) 		PF16827
(zf-HC3) 		4 ALA A  78
PRO A  57
LEU A  91
LEU A  87
 None
 0.83A 5dzkF-3rmsA:
undetectable
5dzkT-3rmsA:
undetectable		 5dzkF-3rmsA:
18.60
5dzkT-3rmsA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Mus musculus) 		PF04389
(Peptidase_M28) 		4 SER A  87
ALA A  88
PRO A  73
LEU A  75
 None
 1.21A 5dzkF-3si1A:
undetectable
5dzkT-3si1A:
undetectable		 5dzkF-3si1A:
22.42
5dzkT-3si1A:
0.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txv PROBABLE TAGATOSE
6-PHOSPHATE KINASE

(Sinorhizobium
meliloti) 		PF08013
(Tagatose_6_P_K) 		4 PRO A  98
MET A 134
LEU A  96
LEU A 155
 None
 1.05A 5dzkF-3txvA:
undetectable
5dzkT-3txvA:
undetectable		 5dzkF-3txvA:
19.38
5dzkT-3txvA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 ALA A 289
PRO A 370
LEU A 372
LEU A 359
 None
 0.86A 5dzkF-3v4cA:
3.0
5dzkT-3v4cA:
undetectable		 5dzkF-3v4cA:
19.92
5dzkT-3v4cA:
0.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL

(Bos taurus) 		PF01597
(GCV_H) 		4 PHE A  52
SER A  38
ALA A  54
PRO A  40
 None
 0.93A 5dzkF-3wdnA:
undetectable
5dzkT-3wdnA:
undetectable		 5dzkF-3wdnA:
21.40
5dzkT-3wdnA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwi PHYTOCHROME-LIKE
PROTEIN CPH2

(Synechocystis
sp.) 		PF00360
(PHY)
PF01590
(GAF) 		4 SER A 411
ALA A 410
PRO A 312
LEU A 342
 None
 0.99A 5dzkF-4bwiA:
undetectable
5dzkT-4bwiA:
undetectable		 5dzkF-4bwiA:
21.83
5dzkT-4bwiA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 PHE A 121
MET A  66
LEU A 119
LEU A 118
 None
 1.10A 5dzkF-4byfA:
undetectable
5dzkT-4byfA:
undetectable		 5dzkF-4byfA:
15.66
5dzkT-4byfA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 SER A 754
ALA A 757
HIS A 782
LEU A 955
 None
 0.94A 5dzkF-4cakA:
undetectable
5dzkT-4cakA:
undetectable		 5dzkF-4cakA:
12.32
5dzkT-4cakA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 311
ALA A 310
HIS A 275
LEU A 168
 None
 1.03A 5dzkF-4ewpA:
undetectable
5dzkT-4ewpA:
undetectable		 5dzkF-4ewpA:
21.31
5dzkT-4ewpA:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE

(Mycobacterium
sp. JLS) 		PF04471
(Mrr_cat) 		4 PHE A 157
ALA A 182
HIS A 142
PRO A 155
 None
 1.01A 5dzkF-4f0qA:
undetectable
5dzkT-4f0qA:
undetectable		 5dzkF-4f0qA:
18.64
5dzkT-4f0qA:
0.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40) 		4 PHE B 281
SER B 263
ALA B 262
HIS B 244
 None
 1.02A 5dzkF-4g56B:
undetectable
5dzkT-4g56B:
undetectable		 5dzkF-4g56B:
21.88
5dzkT-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbm CURM
SULFOTRANSFERASE

(Moorea
producens) 		PF13469
(Sulfotransfer_3) 		4 SER A  57
ALA A  50
PRO A  59
MET A 253
 None
 1.14A 5dzkF-4gbmA:
undetectable
5dzkT-4gbmA:
undetectable		 5dzkF-4gbmA:
20.99
5dzkT-4gbmA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963

(Streptomyces
coelicolor) 		no annotation 4 PHE B 390
PRO B 371
LEU B 389
LEU B 388
 HEM  B 501 (-3.9A)
None
None
HEM  B 501 ( 4.1A)
 0.98A 5dzkF-4gt2B:
undetectable
5dzkT-4gt2B:
undetectable		 5dzkF-4gt2B:
19.24
5dzkT-4gt2B:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwb PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA 3

(Sinorhizobium
meliloti) 		PF01625
(PMSR) 		4 SER A  92
ALA A  93
HIS A  74
LEU A  67
 None
 1.21A 5dzkF-4gwbA:
undetectable
5dzkT-4gwbA:
undetectable		 5dzkF-4gwbA:
22.57
5dzkT-4gwbA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7y DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 4 PHE A  60
ALA A  45
PRO A  13
LEU A  17
 None
 1.20A 5dzkF-4h7yA:
undetectable
5dzkT-4h7yA:
undetectable		 5dzkF-4h7yA:
24.66
5dzkT-4h7yA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		4 SER A 198
ALA A 197
LEU A 228
LEU A 232
 None
None
EDO  A 304 (-4.7A)
None
 1.14A 5dzkF-4imdA:
undetectable
5dzkT-4imdA:
undetectable		 5dzkF-4imdA:
23.29
5dzkT-4imdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		4 PHE A 251
MET A 263
LEU A 249
LEU A 252
 None
 1.19A 5dzkF-4j72A:
undetectable
5dzkT-4j72A:
undetectable		 5dzkF-4j72A:
21.51
5dzkT-4j72A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 SER A 101
ALA A 122
PRO A  49
LEU A  44
 None
 1.07A 5dzkF-4mrqA:
undetectable
5dzkT-4mrqA:
undetectable		 5dzkF-4mrqA:
19.43
5dzkT-4mrqA:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 ALA A 207
PRO A 240
LEU A 252
LEU A 256
 None
 0.97A 5dzkF-4o1oA:
undetectable
5dzkT-4o1oA:
undetectable		 5dzkF-4o1oA:
15.46
5dzkT-4o1oA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 SER A  21
ALA A  22
LEU A  14
LEU A  13
 None
 1.02A 5dzkF-4pv4A:
undetectable
5dzkT-4pv4A:
undetectable		 5dzkF-4pv4A:
18.49
5dzkT-4pv4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		4 PHE A 173
SER A 120
ALA A 123
PRO A 155
 None
 0.95A 5dzkF-4q22A:
undetectable
5dzkT-4q22A:
undetectable		 5dzkF-4q22A:
20.51
5dzkT-4q22A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 PRO A  76
MET A 273
LEU A  74
LEU A  66
 None
 1.05A 5dzkF-4qtsA:
undetectable
5dzkT-4qtsA:
undetectable		 5dzkF-4qtsA:
20.10
5dzkT-4qtsA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raa PUTATIVE EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF17170
(DUF5128) 		4 PHE A 253
PRO A 249
LEU A 251
LEU A 254
 None
 1.13A 5dzkF-4raaA:
undetectable
5dzkT-4raaA:
undetectable		 5dzkF-4raaA:
22.79
5dzkT-4raaA:
3.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2

(Mycobacterium
tuberculosis) 		PF00574
(CLP_protease) 		6 PHE A  83
SER A 110
ALA A 111
HIS A 135
PRO A 137
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 (-3.8A)
ZIL  A 301 ( 2.9A)
 0.46A 5dzkF-4u0gA:
27.4
5dzkT-4u0gA:
undetectable		 5dzkF-4u0gA:
100.00
5dzkT-4u0gA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w79 PROTEIN N-TERMINAL
GLUTAMINE
AMIDOHYDROLASE

(Homo sapiens) 		PF09764
(Nt_Gln_amidase) 		4 PHE A  94
SER A  15
ALA A  14
LEU A  84
 None
 0.98A 5dzkF-4w79A:
undetectable
5dzkT-4w79A:
undetectable		 5dzkF-4w79A:
19.91
5dzkT-4w79A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ALA A 635
PRO A 638
LEU A 647
LEU A 644
 None
EDO  A 721 (-4.2A)
None
EDO  A 721 ( 4.8A)
 1.04A 5dzkF-4wd1A:
undetectable
5dzkT-4wd1A:
undetectable		 5dzkF-4wd1A:
15.50
5dzkT-4wd1A:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A 611
ALA A 613
HIS A 618
LEU A 540
 None
 1.16A 5dzkF-4y07A:
undetectable
5dzkT-4y07A:
undetectable		 5dzkF-4y07A:
20.95
5dzkT-4y07A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Yersinia pestis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 278
ALA A 277
HIS A 243
LEU A 142
 None
None
SCY  A 112 ( 3.7A)
None
 0.97A 5dzkF-4z19A:
undetectable
5dzkT-4z19A:
undetectable		 5dzkF-4z19A:
22.57
5dzkT-4z19A:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		4 SER A 248
ALA A 249
PRO A 313
LEU A 308
 None
 1.13A 5dzkF-4z43A:
undetectable
5dzkT-4z43A:
undetectable		 5dzkF-4z43A:
18.55
5dzkT-4z43A:
0.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 SER A1005
PRO A1248
LEU A1001
LEU A 998
 None
 1.01A 5dzkF-5amqA:
undetectable
5dzkT-5amqA:
undetectable		 5dzkF-5amqA:
6.74
5dzkT-5amqA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 SER A 164
ALA A 163
LEU A 222
LEU A 219
 None
 0.99A 5dzkF-5dkuA:
undetectable
5dzkT-5dkuA:
undetectable		 5dzkF-5dkuA:
14.93
5dzkT-5dkuA:
1.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum) 		PF00232
(Glyco_hydro_1) 		4 PHE A 168
ALA A 243
HIS A 309
LEU A 173
 None
 1.14A 5dzkF-5dt5A:
2.1
5dzkT-5dt5A:
undetectable		 5dzkF-5dt5A:
21.02
5dzkT-5dt5A:
0.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 PHE C 132
SER C  83
LEU C 134
LEU C 133
 None
 1.07A 5dzkF-5dwzC:
undetectable
5dzkT-5dwzC:
undetectable		 5dzkF-5dwzC:
21.01
5dzkT-5dwzC:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyr VIRULENCE-ASSOCIATED
PROTEIN D

(Xylella
fastidiosa) 		PF09827
(CRISPR_Cas2) 		4 PHE A  92
ALA A  90
HIS A  37
LEU A  84
 None
 1.08A 5dzkF-5dyrA:
2.4
5dzkT-5dyrA:
undetectable		 5dzkF-5dyrA:
22.88
5dzkT-5dyrA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		4 PHE A 171
SER A 122
ALA A 125
LEU A 169
 MPG  A 617 ( 4.5A)
None
None
5TR  A 681 ( 4.3A)
 1.06A 5dzkF-5f15A:
undetectable
5dzkT-5f15A:
undetectable		 5dzkF-5f15A:
16.67
5dzkT-5f15A:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 PHE B1197
SER B1144
ALA B1147
PRO B1179
 None
FMT  B4007 (-4.8A)
None
None
 0.94A 5dzkF-5gztB:
1.6
5dzkT-5gztB:
undetectable		 5dzkF-5gztB:
11.94
5dzkT-5gztB:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 PHE A 230
ALA A 202
LEU A  79
LEU A  80
 None
 1.06A 5dzkF-5jxkA:
undetectable
5dzkT-5jxkA:
undetectable		 5dzkF-5jxkA:
17.41
5dzkT-5jxkA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY

(Thermomonospora
curvata) 		PF04261
(Dyp_perox) 		4 PHE A 348
PRO A 329
LEU A 347
LEU A 346
 HEM  A 501 (-3.9A)
None
None
HEM  A 501 ( 4.3A)
 0.88A 5dzkF-5jxuA:
undetectable
5dzkT-5jxuA:
undetectable		 5dzkF-5jxuA:
20.68
5dzkT-5jxuA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mal LIPASE

(Streptomyces
rimosus) 		PF13472
(Lipase_GDSL_2) 		4 SER A  41
ALA A  40
HIS A  42
LEU A 227
 None
 1.04A 5dzkF-5malA:
2.2
5dzkT-5malA:
undetectable		 5dzkF-5malA:
23.20
5dzkT-5malA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		4 PHE A 390
PRO A 371
LEU A 389
LEU A 388
 HEM  A 901 (-3.8A)
None
None
HEM  A 901 ( 4.1A)
 0.99A 5dzkF-5mapA:
undetectable
5dzkT-5mapA:
undetectable		 5dzkF-5mapA:
22.01
5dzkT-5mapA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE

(Thermobifida
fusca) 		PF03807
(F420_oxidored) 		4 SER A 132
ALA A 133
LEU A 201
LEU A 173
 None
 1.09A 5dzkF-5n2iA:
undetectable
5dzkT-5n2iA:
undetectable		 5dzkF-5n2iA:
21.65
5dzkT-5n2iA:
1.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyw PROTEASOME SUBUNIT

(Yersinia
bercovieri) 		no annotation 4 PHE A 128
ALA A 139
LEU A 115
LEU A 116
 None
 1.15A 5dzkF-5nywA:
undetectable
5dzkT-5nywA:
undetectable		 5dzkF-5nywA:
22.71
5dzkT-5nywA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00397
(WW)
PF00632
(HECT) 		4 PHE A 611
ALA A 613
HIS A 618
LEU A 540
 None
 1.15A 5dzkF-5tj7A:
undetectable
5dzkT-5tj7A:
undetectable		 5dzkF-5tj7A:
19.46
5dzkT-5tj7A:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN

(Arthrospira
maxima) 		PF02136
(NTF2)
PF09150
(Carot_N) 		4 PHE A 301
ALA A 220
LEU A 294
LEU A 293
 None
 1.02A 5dzkF-5ui2A:
undetectable
5dzkT-5ui2A:
undetectable		 5dzkF-5ui2A:
21.34
5dzkT-5ui2A:
0.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF13401
(AAA_22)
PF14630
(ORC5_C) 		4 PHE E 390
SER E 335
ALA E 334
LEU E 387
 None
 0.96A 5dzkF-5v8fE:
undetectable
5dzkT-5v8fE:
undetectable		 5dzkF-5v8fE:
18.94
5dzkT-5v8fE:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE

(Streptococcus
pneumoniae) 		no annotation 4 PHE A 363
ALA A 365
HIS A 261
LEU A 359
 None
HMG  A 500 (-3.3A)
None
None
 1.11A 5dzkF-5wpkA:
undetectable
5dzkT-5wpkA:
undetectable		 5dzkF-5wpkA:
undetectable
5dzkT-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xlk FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Serratia
marcescens) 		PF07195
(FliD_C)
PF07196
(Flagellin_IN) 		4 ALA A 111
MET A 219
LEU A 120
LEU A 203
 None
 1.21A 5dzkF-5xlkA:
undetectable
5dzkT-5xlkA:
undetectable		 5dzkF-5xlkA:
24.59
5dzkT-5xlkA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 4 ALA 4 403
PRO 4 533
LEU 4 511
LEU 4 508
 None
 0.87A 5dzkF-5zvs4:
undetectable
5dzkT-5zvs4:
undetectable		 5dzkF-5zvs4:
undetectable
5dzkT-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azi D-ALANYL-D-ALANINE
ENDOPEPTIDASE

(Enterobacter
cloacae) 		PF00768
(Peptidase_S11) 		4 SER A 174
MET A 259
LEU A 182
LEU A 183
 None
 1.06A 5dzkF-6aziA:
undetectable
5dzkT-6aziA:
undetectable		 5dzkF-6aziA:
21.63
5dzkT-6aziA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4m MONOTREME LACTATION
PROTEIN

(Ornithorhynchus
anatinus) 		no annotation 4 ALA A  20
PRO A  31
LEU A  33
LEU A  62
 None
 0.76A 5dzkF-6b4mA:
undetectable
5dzkT-6b4mA:
undetectable		 5dzkF-6b4mA:
undetectable
5dzkT-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON

(Streptomyces
fradiae) 		no annotation 4 PHE A 154
ALA A 127
LEU A 160
LEU A 159
 None
 1.20A 5dzkF-6cblA:
undetectable
5dzkT-6cblA:
undetectable		 5dzkF-6cblA:
undetectable
5dzkT-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2d FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIP
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIR

(Salmonella
enterica;
Salmonella
enterica) 		no annotation
no annotation 		4 SER F  34
HIS F 143
MET F 134
LEU A 179
 None
 1.08A 5dzkF-6f2dF:
undetectable
5dzkT-6f2dF:
undetectable		 5dzkF-6f2dF:
undetectable
5dzkT-6f2dF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A  62
HIS A  65
PRO A  38
LEU A  58
 None
 1.20A 5dzkF-6f91A:
undetectable
5dzkT-6f91A:
undetectable		 5dzkF-6f91A:
undetectable
5dzkT-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffl MALTOSE/MALTODEXTRIN
TRANSPORT PERMEASE
HOMOLOGUE

(Bdellovibrio
bacteriovorus) 		no annotation 4 SER A 331
ALA A 332
HIS A 115
LEU A 310
 None
 1.12A 5dzkF-6fflA:
undetectable
5dzkT-6fflA:
undetectable		 5dzkF-6fflA:
undetectable
5dzkT-6fflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fks -

(-) 		no annotation 4 SER A  34
ALA A  33
LEU A  94
LEU A  23
 None
 0.93A 5dzkF-6fksA:
undetectable
5dzkT-6fksA:
undetectable		 5dzkF-6fksA:
undetectable
5dzkT-6fksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 4 PHE L 335
SER L 250
ALA L 333
LEU L 339
 None
 1.20A 5dzkF-6g2jL:
undetectable
5dzkT-6g2jL:
undetectable		 5dzkF-6g2jL:
undetectable
5dzkT-6g2jL:
undetectable