SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_T_BEZT801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5w MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.11A 5dzkf-1e5wA:
undetectable
5dzkt-1e5wA:
undetectable		 5dzkf-1e5wA:
21.01
5dzkt-1e5wA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eco ERYTHROCRUORIN
(CARBONMONOXY)

(Chironomus
thummi) 		PF00042
(Globin) 		4 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.94A 5dzkf-1ecoA:
undetectable
5dzkt-1ecoA:
undetectable		 5dzkf-1ecoA:
22.12
5dzkt-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 SER A  82
ALA A 107
HIS A 251
LEU A 162
 OCP  A 382 (-1.5A)
None
OCP  A 382 (-3.9A)
OCP  A 382 ( 4.4A)
 1.25A 5dzkf-1ex9A:
0.5
5dzkt-1ex9A:
undetectable		 5dzkf-1ex9A:
23.79
5dzkt-1ex9A:
0.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flk TNF RECEPTOR
ASSOCIATED FACTOR 3

(Homo sapiens) 		no annotation 4 SER A 378
ALA A 392
MET A 414
LEU A 354
 None
 1.02A 5dzkf-1flkA:
undetectable
5dzkt-1flkA:
undetectable		 5dzkf-1flkA:
21.94
5dzkt-1flkA:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gc7 RADIXIN

(Mus musculus) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.06A 5dzkf-1gc7A:
0.0
5dzkt-1gc7A:
undetectable		 5dzkf-1gc7A:
19.68
5dzkt-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 SER A  30
ALA A  29
HIS A  31
LEU A 219
 None
 1.38A 5dzkf-1gtkA:
0.0
5dzkt-1gtkA:
undetectable		 5dzkf-1gtkA:
24.61
5dzkt-1gtkA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idt MINOR FMN-DEPENDENT
NITROREDUCTASE

(Escherichia
coli) 		PF00881
(Nitroreductase) 		4 SER A  79
ALA A  78
HIS A  80
LEU A 159
 None
 1.41A 5dzkf-1idtA:
0.0
5dzkt-1idtA:
undetectable		 5dzkf-1idtA:
24.19
5dzkt-1idtA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmk SURFACTIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		4 SER C  80
ALA C  81
HIS C 207
LEU C 129
 None
 1.30A 5dzkf-1jmkC:
1.5
5dzkt-1jmkC:
undetectable		 5dzkf-1jmkC:
22.92
5dzkt-1jmkC:
1.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzn GALACTOSE-SPECIFIC
LECTIN

(Crotalus atrox) 		PF00059
(Lectin_C) 		4 SER A  42
ALA A  41
HIS A  44
LEU A  13
 NA  A1139 (-2.9A)
None
None
None
 1.02A 5dzkf-1jznA:
undetectable
5dzkt-1jznA:
undetectable		 5dzkf-1jznA:
18.02
5dzkt-1jznA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		4 SER A1056
ALA A1054
HIS A1163
LEU A1091
 None
 1.43A 5dzkf-1lurA:
undetectable
5dzkt-1lurA:
undetectable		 5dzkf-1lurA:
21.78
5dzkt-1lurA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgo ANAEROBIC COBALAMIN
BIOSYNTHETIC COBALT
CHELATASE

(Salmonella
enterica) 		PF06180
(CbiK) 		4 SER A  32
ALA A  31
HIS A 253
LEU A   5
 None
 1.21A 5dzkf-1qgoA:
2.1
5dzkt-1qgoA:
undetectable		 5dzkf-1qgoA:
21.11
5dzkt-1qgoA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgo ANAEROBIC COBALAMIN
BIOSYNTHETIC COBALT
CHELATASE

(Salmonella
enterica) 		PF06180
(CbiK) 		4 SER A  32
ALA A  31
HIS A 253
LEU A  29
 None
 1.20A 5dzkf-1qgoA:
2.1
5dzkt-1qgoA:
undetectable		 5dzkf-1qgoA:
21.11
5dzkt-1qgoA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3i PROBABLE CYSTEINE
DESULFURASE

(Synechocystis
sp.) 		PF00266
(Aminotran_5) 		4 SER A 209
ALA A 210
HIS A 177
LEU A 225
 None
 1.35A 5dzkf-1t3iA:
undetectable
5dzkt-1t3iA:
undetectable		 5dzkf-1t3iA:
18.37
5dzkt-1t3iA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 SER A 268
ALA A 266
HIS A 536
MET A 570
 None
 1.06A 5dzkf-1we5A:
undetectable
5dzkt-1we5A:
undetectable		 5dzkf-1we5A:
13.64
5dzkt-1we5A:
0.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00782
(DSPc) 		4 SER A 190
ALA A 265
HIS A 193
MET A 299
 None
SO4  A 501 (-3.4A)
None
None
 1.41A 5dzkf-2g6zA:
undetectable
5dzkt-2g6zA:
undetectable		 5dzkf-2g6zA:
23.31
5dzkt-2g6zA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		4 SER A 329
ALA A 332
HIS A 327
MET A   9
 None
 1.19A 5dzkf-2greA:
undetectable
5dzkt-2greA:
undetectable		 5dzkf-2greA:
20.80
5dzkt-2greA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT
TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri;
Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS)
PF02332
(Phenol_Hydrox) 		4 SER A 108
ALA A 107
HIS B 143
MET A 181
 None
P6G  A 503 ( 3.8A)
None
None
 1.45A 5dzkf-2incA:
undetectable
5dzkt-2incA:
undetectable		 5dzkf-2incA:
19.91
5dzkt-2incA:
0.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8y PROTEIN RCSF

(Escherichia
coli) 		PF16358
(RcsF) 		4 SER A 127
ALA A 128
HIS A 107
MET A  92
 None
 1.27A 5dzkf-2l8yA:
undetectable
5dzkt-2l8yA:
undetectable		 5dzkf-2l8yA:
20.10
5dzkt-2l8yA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 327
ALA A 326
HIS A 340
MET A 358
 None
 1.39A 5dzkf-2nqlA:
undetectable
5dzkt-2nqlA:
undetectable		 5dzkf-2nqlA:
19.95
5dzkt-2nqlA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 328
ALA A 327
HIS A 341
MET A 359
 None
 1.44A 5dzkf-2ppgA:
undetectable
5dzkt-2ppgA:
undetectable		 5dzkf-2ppgA:
19.85
5dzkt-2ppgA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri) 		PF07201
(HrpJ) 		4 SER A 306
ALA A 305
HIS A 307
LEU A 273
 None
 1.50A 5dzkf-2vj5A:
undetectable
5dzkt-2vj5A:
undetectable		 5dzkf-2vj5A:
22.26
5dzkt-2vj5A:
0.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x26 PERIPLASMIC
ALIPHATIC
SULPHONATES-BINDING
PROTEIN

(Escherichia
coli) 		PF09084
(NMT1) 		4 SER A 264
ALA A 263
HIS A 268
LEU A 192
 None
 1.34A 5dzkf-2x26A:
undetectable
5dzkt-2x26A:
undetectable		 5dzkf-2x26A:
23.59
5dzkt-2x26A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y1b PUTATIVE OUTER
MEMBRANE PROTEIN,
SIGNAL

(Escherichia
coli) 		PF16358
(RcsF) 		4 SER A 127
ALA A 128
HIS A 107
MET A  92
 None
None
I3C  A1133 (-3.6A)
None
 1.03A 5dzkf-2y1bA:
undetectable
5dzkt-2y1bA:
undetectable		 5dzkf-2y1bA:
20.72
5dzkt-2y1bA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		4 SER A  95
ALA A  94
HIS A 251
LEU A 310
 None
 1.36A 5dzkf-2zukA:
undetectable
5dzkt-2zukA:
undetectable		 5dzkf-2zukA:
20.45
5dzkt-2zukA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 SER A 180
ALA A 248
HIS A 184
LEU A 246
 None
 1.35A 5dzkf-3breA:
undetectable
5dzkt-3breA:
undetectable		 5dzkf-3breA:
19.83
5dzkt-3breA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 SER A 201
ALA A 204
MET A 282
LEU A 270
 None
 1.21A 5dzkf-3hf1A:
undetectable
5dzkt-3hf1A:
undetectable		 5dzkf-3hf1A:
20.51
5dzkt-3hf1A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE

(Salmonella
enterica) 		PF00881
(Nitroreductase) 		4 SER A  79
ALA A  78
HIS A  80
LEU A 159
 None
None
TLA  A 218 (-4.0A)
None
 1.38A 5dzkf-3hznA:
undetectable
5dzkt-3hznA:
undetectable		 5dzkf-3hznA:
22.18
5dzkt-3hznA:
1.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocr CLASS II
ALDOLASE/ADDUCIN
DOMAIN PROTEIN

(Pseudomonas
savastanoi) 		PF00596
(Aldolase_II) 		4 SER A  57
ALA A  58
HIS A 110
LEU A 124
 None
 1.36A 5dzkf-3ocrA:
undetectable
5dzkt-3ocrA:
undetectable		 5dzkf-3ocrA:
22.76
5dzkt-3ocrA:
1.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q7h ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Coxiella
burnetii) 		PF00574
(CLP_protease) 		4 SER A  99
ALA A 102
HIS A 124
LEU A 151
 None
 1.44A 5dzkf-3q7hA:
27.0
5dzkt-3q7hA:
undetectable		 5dzkf-3q7hA:
47.12
5dzkt-3q7hA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw4 UMP SYNTHASE

(Leishmania
donovani) 		PF00156
(Pribosyltran)
PF00215
(OMPdecase) 		4 SER B 331
ALA B 330
MET B 300
LEU B 327
 None
 1.39A 5dzkf-3qw4B:
undetectable
5dzkt-3qw4B:
undetectable		 5dzkf-3qw4B:
19.91
5dzkt-3qw4B:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rac HISTIDINE-TRNA
LIGASE

(Alicyclobacillus
acidocaldarius) 		PF13393
(tRNA-synt_His) 		4 SER A 171
ALA A 170
HIS A 179
LEU A 167
 None
 1.20A 5dzkf-3racA:
undetectable
5dzkt-3racA:
undetectable		 5dzkf-3racA:
20.38
5dzkt-3racA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		4 ALA B 576
HIS B 554
MET B 583
LEU B 614
 None
 1.44A 5dzkf-3s4wB:
2.7
5dzkt-3s4wB:
undetectable		 5dzkf-3s4wB:
9.61
5dzkt-3s4wB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Coxiella
burnetii) 		PF01590
(GAF) 		4 SER A 134
ALA A  90
HIS A 110
LEU A  94
 None
 1.09A 5dzkf-3trcA:
undetectable
5dzkt-3trcA:
undetectable		 5dzkf-3trcA:
23.89
5dzkt-3trcA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad8 DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 SER A 150
ALA A 151
HIS A 146
LEU A 450
 None
 1.40A 5dzkf-4ad8A:
undetectable
5dzkt-4ad8A:
undetectable		 5dzkf-4ad8A:
18.58
5dzkt-4ad8A:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40) 		4 SER B 263
ALA B 262
HIS B 244
LEU B 273
 None
 1.25A 5dzkf-4g56B:
undetectable
5dzkt-4g56B:
undetectable		 5dzkf-4g56B:
21.88
5dzkt-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h17 HYDROLASE,
ISOCHORISMATASE
FAMILY

(Pseudomonas
putida) 		PF00857
(Isochorismatase) 		4 SER A 157
ALA A 156
HIS A 175
LEU A 152
 None
None
EDO  A 206 ( 4.1A)
None
 1.05A 5dzkf-4h17A:
undetectable
5dzkt-4h17A:
undetectable		 5dzkf-4h17A:
24.27
5dzkt-4h17A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 SER A2274
ALA A2273
MET A1607
LEU A2270
 None
 1.03A 5dzkf-4rlvA:
undetectable
5dzkt-4rlvA:
undetectable		 5dzkf-4rlvA:
13.96
5dzkt-4rlvA:
1.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2

(Mycobacterium
tuberculosis) 		PF00574
(CLP_protease) 		4 SER A 110
ALA A 111
HIS A 135
MET A 164
 ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 ( 2.9A)
 0.42A 5dzkf-4u0gA:
27.4
5dzkt-4u0gA:
undetectable		 5dzkf-4u0gA:
100.00
5dzkt-4u0gA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		4 SER A 300
ALA A 309
HIS A 320
LEU A  32
 None
 1.32A 5dzkf-4u9oA:
undetectable
5dzkt-4u9oA:
undetectable		 5dzkf-4u9oA:
22.04
5dzkt-4u9oA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvj COHESIN SUBUNIT SCC3

(Saccharomyces
cerevisiae) 		no annotation 4 SER A 692
ALA A 691
MET A 746
LEU A 688
 None
 0.82A 5dzkf-4uvjA:
undetectable
5dzkt-4uvjA:
undetectable		 5dzkf-4uvjA:
20.15
5dzkt-4uvjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 SER A 164
ALA A 165
HIS A 291
MET A 218
 None
 1.20A 5dzkf-4wy8A:
2.3
5dzkt-4wy8A:
undetectable		 5dzkf-4wy8A:
22.94
5dzkt-4wy8A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		4 SER A 158
ALA A 159
HIS A 155
MET A 148
 None
 1.46A 5dzkf-4wyiA:
2.6
5dzkt-4wyiA:
undetectable		 5dzkf-4wyiA:
20.99
5dzkt-4wyiA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		4 SER A 158
ALA A 161
HIS A 155
LEU A 321
 None
 1.38A 5dzkf-4wyiA:
2.6
5dzkt-4wyiA:
undetectable		 5dzkf-4wyiA:
20.99
5dzkt-4wyiA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		4 SER A 159
ALA A 160
HIS A 283
MET A 213
 None
 1.22A 5dzkf-4ypvA:
2.6
5dzkt-4ypvA:
undetectable		 5dzkf-4ypvA:
22.35
5dzkt-4ypvA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 SER A  76
ALA A 358
HIS A 320
LEU A 131
 None
 1.38A 5dzkf-4yzoA:
undetectable
5dzkt-4yzoA:
undetectable		 5dzkf-4yzoA:
19.79
5dzkt-4yzoA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgf UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF16139
(DUF4847) 		4 SER A  31
ALA A  30
HIS A 160
LEU A 145
 None
None
P6G  A 205 ( 3.9A)
None
 1.40A 5dzkf-4zgfA:
undetectable
5dzkt-4zgfA:
undetectable		 5dzkf-4zgfA:
21.89
5dzkt-4zgfA:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3n ANTI-H4K20ME1_SCFV

(Mus musculus) 		PF07686
(V-set) 		4 SER A  37
ALA A  51
HIS A 101
LEU A 238
 None
 1.32A 5dzkf-5b3nA:
undetectable
5dzkt-5b3nA:
undetectable		 5dzkf-5b3nA:
22.42
5dzkt-5b3nA:
1.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu6 BPSB (PGAB),
POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Bordetella
bronchiseptica) 		PF01522
(Polysacc_deac_1) 		4 ALA A  57
HIS A 189
MET A  62
LEU A  55
 None
NI  A 401 ( 3.3A)
None
None
 1.47A 5dzkf-5bu6A:
undetectable
5dzkt-5bu6A:
undetectable		 5dzkf-5bu6A:
22.22
5dzkt-5bu6A:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		4 SER A 320
ALA A 319
HIS A 295
LEU A 257
 None
 1.37A 5dzkf-5ck7A:
undetectable
5dzkt-5ck7A:
undetectable		 5dzkf-5ck7A:
20.42
5dzkt-5ck7A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d88 PREDICTED PROTEASE
OF THE COLLAGENASE
FAMILY

(Methanopyrus
kandleri) 		PF01136
(Peptidase_U32) 		4 SER A 120
ALA A 101
HIS A 121
LEU A  63
 None
None
ACT  A 302 (-3.9A)
None
 1.40A 5dzkf-5d88A:
2.4
5dzkt-5d88A:
undetectable		 5dzkf-5d88A:
22.18
5dzkt-5d88A:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156

(uncultured
organism) 		no annotation 4 SER A 232
ALA A 261
HIS A 231
LEU A 352
 None
 0.91A 5dzkf-5d8mA:
2.3
5dzkt-5d8mA:
undetectable		 5dzkf-5d8mA:
22.62
5dzkt-5d8mA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elp NRPS/PKS PROTEIN

(Bacillus
amyloliquefaciens) 		no annotation 4 SER C 420
ALA C 316
HIS C 430
LEU C 332
 None
 1.40A 5dzkf-5elpC:
undetectable
5dzkt-5elpC:
undetectable		 5dzkf-5elpC:
15.27
5dzkt-5elpC:
1.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Streptococcus
porcinus) 		PF01791
(DeoC) 		4 SER A 240
ALA A 239
HIS A 241
LEU A 203
 None
 1.40A 5dzkf-5hjlA:
1.9
5dzkt-5hjlA:
undetectable		 5dzkf-5hjlA:
22.80
5dzkt-5hjlA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 SER B 337
ALA B 334
HIS B 341
LEU B 732
 None
 1.15A 5dzkf-5iz5B:
undetectable
5dzkt-5iz5B:
undetectable		 5dzkf-5iz5B:
13.54
5dzkt-5iz5B:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		4 ALA A 355
HIS A  54
MET A 399
LEU A 352
 None
 1.45A 5dzkf-5j7zA:
2.5
5dzkt-5j7zA:
undetectable		 5dzkf-5j7zA:
18.38
5dzkt-5j7zA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7v DESIGNED PROTEIN
HR00C3

(synthetic
construct) 		no annotation 4 SER A 183
ALA A 182
MET A 129
LEU A 180
 None
 1.05A 5dzkf-5k7vA:
undetectable
5dzkt-5k7vA:
undetectable		 5dzkf-5k7vA:
23.15
5dzkt-5k7vA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III

(Rhizobium
freirei) 		PF00202
(Aminotran_3) 		4 SER A  95
ALA A  94
HIS A 251
LEU A 310
 None
 1.41A 5dzkf-5m49A:
undetectable
5dzkt-5m49A:
undetectable		 5dzkf-5m49A:
20.95
5dzkt-5m49A:
1.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mal LIPASE

(Streptomyces
rimosus) 		PF13472
(Lipase_GDSL_2) 		4 SER A  41
ALA A  40
HIS A  42
LEU A 227
 None
 1.01A 5dzkf-5malA:
2.3
5dzkt-5malA:
undetectable		 5dzkf-5malA:
23.20
5dzkt-5malA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 SER B 619
ALA B 616
MET B 608
LEU B 676
 None
 1.45A 5dzkf-5mrwB:
undetectable
5dzkt-5mrwB:
undetectable		 5dzkf-5mrwB:
16.36
5dzkt-5mrwB:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		4 SER f 409
ALA f 410
MET f 416
LEU f 372
 None
 1.28A 5dzkf-5vhif:
undetectable
5dzkt-5vhif:
undetectable		 5dzkf-5vhif:
13.63
5dzkt-5vhif:
1.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 4 ALA A 123
HIS A 119
MET A  92
LEU A 104
 None
 1.49A 5dzkf-5w76A:
undetectable
5dzkt-5w76A:
undetectable		 5dzkf-5w76A:
undetectable
5dzkt-5w76A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 SER A2274
ALA A2273
MET A1615
LEU A2270
 None
 1.04A 5dzkf-5y4dA:
undetectable
5dzkt-5y4dA:
undetectable		 5dzkf-5y4dA:
14.73
5dzkt-5y4dA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgi ANOCTAMIN-1

(Mus musculus) 		no annotation 4 SER A 401
ALA A 400
HIS A 402
LEU A 630
 None
 1.38A 5dzkf-6bgiA:
undetectable
5dzkt-6bgiA:
undetectable		 5dzkf-6bgiA:
undetectable
5dzkt-6bgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE

(Mycobacterium
tuberculosis) 		no annotation 4 SER C 110
ALA C 136
HIS C 109
LEU C 228
 MPD  C 302 (-3.3A)
SO4  C 301 ( 4.0A)
MPD  C 302 (-4.3A)
SO4  C 301 ( 4.4A)
 0.97A 5dzkf-6eicC:
3.4
5dzkt-6eicC:
undetectable		 5dzkf-6eicC:
undetectable
5dzkt-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2d FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIP
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIR

(Salmonella
enterica;
Salmonella
enterica) 		no annotation
no annotation 		4 SER F  34
HIS F 143
MET F 134
LEU A 179
 None
 1.07A 5dzkf-6f2dF:
undetectable
5dzkt-6f2dF:
undetectable		 5dzkf-6f2dF:
undetectable
5dzkt-6f2dF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffl MALTOSE/MALTODEXTRIN
TRANSPORT PERMEASE
HOMOLOGUE

(Bdellovibrio
bacteriovorus) 		no annotation 4 SER A 331
ALA A 332
HIS A 115
LEU A 310
 None
 1.31A 5dzkf-6fflA:
undetectable
5dzkt-6fflA:
undetectable		 5dzkf-6fflA:
undetectable
5dzkt-6fflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		4 SER A 209
ALA A 210
HIS A 449
LEU A 302
 None
 1.13A 5dzkF-1crlA:
0.3
5dzkT-1crlA:
undetectable		 5dzkF-1crlA:
17.18
5dzkT-1crlA:
0.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		4 ALA A 259
HIS A 234
LEU A 214
LEU A 215
 None
 1.03A 5dzkF-1dgmA:
2.0
5dzkT-1dgmA:
undetectable		 5dzkF-1dgmA:
21.27
5dzkT-1dgmA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 279
ALA A 278
HIS A 244
LEU A 142
 None
None
COA  A1350 (-4.4A)
None
 1.02A 5dzkF-1eblA:
undetectable
5dzkT-1eblA:
undetectable		 5dzkF-1eblA:
21.18
5dzkT-1eblA:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eco ERYTHROCRUORIN
(CARBONMONOXY)

(Chironomus
thummi) 		PF00042
(Globin) 		4 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.95A 5dzkF-1ecoA:
undetectable
5dzkT-1ecoA:
undetectable		 5dzkF-1ecoA:
22.12
5dzkT-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 SER A  56
HIS A 199
PRO A 235
LEU A 237
 None
 1.14A 5dzkF-1ezvA:
0.0
5dzkT-1ezvA:
undetectable		 5dzkF-1ezvA:
18.79
5dzkT-1ezvA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		4 SER A 174
ALA A 175
HIS A 286
PRO A 178
 None
 1.07A 5dzkF-1gzvA:
0.5
5dzkT-1gzvA:
undetectable		 5dzkF-1gzvA:
16.52
5dzkT-1gzvA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgc BACTERIOFERRITIN

(Rhodobacter
capsulatus) 		PF00210
(Ferritin) 		4 ALA A  60
PRO A  69
LEU A  11
LEU A  15
 None
 1.20A 5dzkF-1jgcA:
undetectable
5dzkT-1jgcA:
undetectable		 5dzkF-1jgcA:
22.07
5dzkT-1jgcA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzn GALACTOSE-SPECIFIC
LECTIN

(Crotalus atrox) 		PF00059
(Lectin_C) 		4 SER A  42
ALA A  41
HIS A  44
LEU A  13
 NA  A1139 (-2.9A)
None
None
None
 1.15A 5dzkF-1jznA:
undetectable
5dzkT-1jznA:
undetectable		 5dzkF-1jznA:
18.02
5dzkT-1jznA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 SER A 248
ALA A 249
HIS A 197
PRO A 184
 None
 1.18A 5dzkF-1l5jA:
0.6
5dzkT-1l5jA:
undetectable		 5dzkF-1l5jA:
13.89
5dzkT-1l5jA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 PHE A 612
ALA A 476
HIS A 555
LEU A 613
 None
 1.00A 5dzkF-1llaA:
undetectable
5dzkT-1llaA:
undetectable		 5dzkF-1llaA:
15.40
5dzkT-1llaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Mycobacterium
tuberculosis) 		PF01625
(PMSR) 		4 SER A  94
ALA A  95
HIS A  76
LEU A  69
 None
 1.21A 5dzkF-1nwaA:
0.0
5dzkT-1nwaA:
undetectable		 5dzkF-1nwaA:
20.08
5dzkT-1nwaA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 SER A 103
ALA A  76
HIS A 180
LEU A  73
 None
 0.99A 5dzkF-1pgpA:
undetectable
5dzkT-1pgpA:
undetectable		 5dzkF-1pgpA:
17.63
5dzkT-1pgpA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		4 PHE A  28
SER A 206
PRO A  93
LEU A  23
 None
 0.95A 5dzkF-1u9cA:
undetectable
5dzkT-1u9cA:
undetectable		 5dzkF-1u9cA:
25.70
5dzkT-1u9cA:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y30 HYPOTHETICAL PROTEIN
RV1155

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		4 ALA A  82
PRO A 135
LEU A  45
LEU A  46
 None
 1.18A 5dzkF-1y30A:
undetectable
5dzkT-1y30A:
undetectable		 5dzkF-1y30A:
21.30
5dzkT-1y30A:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE

(Moorella
thermoacetica) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 SER A 152
ALA A 144
HIS A  81
LEU A 200
 None
None
FEO  A 501 (-3.3A)
None
 1.01A 5dzkF-1ycgA:
undetectable
5dzkT-1ycgA:
undetectable		 5dzkF-1ycgA:
22.19
5dzkT-1ycgA:
0.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 ALA A  47
HIS A 303
PRO A 305
LEU A 277
 None
 1.10A 5dzkF-2cy7A:
undetectable
5dzkT-2cy7A:
undetectable		 5dzkF-2cy7A:
20.33
5dzkT-2cy7A:
0.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		4 PHE A 357
PRO A 363
LEU A 359
LEU A 356
 None
 1.11A 5dzkF-2dh3A:
2.4
5dzkT-2dh3A:
undetectable		 5dzkF-2dh3A:
19.39
5dzkT-2dh3A:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		4 PHE A 159
SER A 176
LEU A 129
LEU A 158
 None
 1.07A 5dzkF-2dy0A:
undetectable
5dzkT-2dy0A:
undetectable		 5dzkF-2dy0A:
24.43
5dzkT-2dy0A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8g HYPOTHETICAL PROTEIN
PH0536

(Pyrococcus
horikoshii) 		PF01588
(tRNA_bind) 		4 SER A  16
ALA A  13
MET A  45
LEU A 118
 None
 1.20A 5dzkF-2e8gA:
undetectable
5dzkT-2e8gA:
undetectable		 5dzkF-2e8gA:
20.73
5dzkT-2e8gA:
1.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 SER A 226
ALA A 227
HIS A 471
LEU A 313
 TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
TFC  A 600 (-4.2A)
 1.09A 5dzkF-2fj0A:
2.5
5dzkT-2fj0A:
undetectable		 5dzkF-2fj0A:
17.60
5dzkT-2fj0A:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hky RIBONUCLEASE 7

(Homo sapiens) 		PF00074
(RnaseA) 		4 PHE A 117
SER A   7
PRO A 121
LEU A 119
 None
 0.80A 5dzkF-2hkyA:
undetectable
5dzkT-2hkyA:
undetectable		 5dzkF-2hkyA:
17.92
5dzkT-2hkyA:
1.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7h STRESS-INDUCED
PROTEIN SAM22

(Glycine max) 		PF00407
(Bet_v_1) 		4 ALA A  14
PRO A  12
LEU A 150
LEU A 151
 None
 1.14A 5dzkF-2k7hA:
undetectable
5dzkT-2k7hA:
undetectable		 5dzkF-2k7hA:
21.78
5dzkT-2k7hA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9r BETA-GLUCOSIDASE B

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		4 ALA A 252
PRO A 289
LEU A 293
LEU A 350
 None
 1.02A 5dzkF-2o9rA:
1.6
5dzkT-2o9rA:
undetectable		 5dzkF-2o9rA:
19.64
5dzkT-2o9rA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 SER A 103
ALA A  76
HIS A 179
LEU A  73
 None
 0.94A 5dzkF-2p4qA:
undetectable
5dzkT-2p4qA:
undetectable		 5dzkF-2p4qA:
17.73
5dzkT-2p4qA:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		4 ALA A 335
PRO A 153
LEU A 366
LEU A 365
 None
 1.11A 5dzkF-2pgeA:
2.2
5dzkT-2pgeA:
undetectable		 5dzkF-2pgeA:
22.65
5dzkT-2pgeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 PHE A 476
ALA A 556
PRO A 541
LEU A 539
 None
 1.14A 5dzkF-2vycA:
undetectable
5dzkT-2vycA:
undetectable		 5dzkF-2vycA:
14.97
5dzkT-2vycA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 SER A 142
ALA A 453
LEU A 275
LEU A 272
 None
 1.20A 5dzkF-2xr1A:
undetectable
5dzkT-2xr1A:
undetectable		 5dzkF-2xr1A:
15.70
5dzkT-2xr1A:
0.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 SER A 141
ALA A 453
LEU A 275
LEU A 272
 None
 1.18A 5dzkF-2ycbA:
undetectable
5dzkT-2ycbA:
undetectable		 5dzkF-2ycbA:
15.43
5dzkT-2ycbA:
0.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 ALA A 377
HIS A 379
PRO A 449
LEU A 451
 None
 1.14A 5dzkF-2yr5A:
2.0
5dzkT-2yr5A:
undetectable		 5dzkF-2yr5A:
16.84
5dzkT-2yr5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		4 ALA A 400
PRO A 397
LEU A 393
LEU A 407
 None
 1.06A 5dzkF-2zblA:
undetectable
5dzkT-2zblA:
undetectable		 5dzkF-2zblA:
19.90
5dzkT-2zblA:
1.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii) 		PF00118
(Cpn60_TCP1) 		4 PHE B 281
ALA B 301
LEU B 231
LEU B 230
 None
 1.19A 5dzkF-3aq1B:
2.0
5dzkT-3aq1B:
undetectable		 5dzkF-3aq1B:
18.84
5dzkT-3aq1B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		4 PHE A 546
ALA A 541
LEU A  22
LEU A  26
 None
None
BOG  A 806 (-4.7A)
None
 1.20A 5dzkF-3ayfA:
undetectable
5dzkT-3ayfA:
undetectable		 5dzkF-3ayfA:
14.08
5dzkT-3ayfA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn7 FERREDOXIN-LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF07876
(Dabb) 		4 PHE A  82
ALA A  28
LEU A  78
LEU A  79
 ACT  A 102 (-4.8A)
None
None
None
 1.08A 5dzkF-3bn7A:
undetectable
5dzkT-3bn7A:
undetectable		 5dzkF-3bn7A:
21.60
5dzkT-3bn7A:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ

(Vibrio
vulnificus) 		PF11612
(T2SSJ) 		4 PHE B  91
ALA B  59
LEU B  74
LEU B  75
 None
 0.91A 5dzkF-3cfiB:
undetectable
5dzkT-3cfiB:
undetectable		 5dzkF-3cfiB:
19.91
5dzkT-3cfiB:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		no annotation 4 PHE A 119
ALA A 114
PRO A  77
LEU A 191
 None
 1.07A 5dzkF-3cjiA:
undetectable
5dzkT-3cjiA:
undetectable		 5dzkF-3cjiA:
23.21
5dzkT-3cjiA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed0 (3R)-HYDROXYMYRISTOY
L-ACYL CARRIER
PROTEIN DEHYDRATASE

(Helicobacter
pylori) 		PF07977
(FabA) 		4 PHE A  80
ALA A  44
LEU A 123
LEU A  81
 None
 1.20A 5dzkF-3ed0A:
undetectable
5dzkT-3ed0A:
undetectable		 5dzkF-3ed0A:
23.08
5dzkT-3ed0A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR

(Shewanella
oneidensis) 		PF02661
(Fic)
PF13784
(Fic_N) 		4 ALA A 196
PRO A 199
LEU A 167
LEU A 168
 PGE  A 373 ( 4.1A)
None
None
None
 0.77A 5dzkF-3eqxA:
undetectable
5dzkT-3eqxA:
undetectable		 5dzkF-3eqxA:
18.85
5dzkT-3eqxA:
0.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 300
ALA A 299
HIS A 265
LEU A 183
 None
 1.05A 5dzkF-3fk5A:
undetectable
5dzkT-3fk5A:
undetectable		 5dzkF-3fk5A:
21.83
5dzkT-3fk5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 PHE A  48
SER A 152
ALA A 153
HIS A 348
 None
 1.21A 5dzkF-3i1iA:
undetectable
5dzkT-3i1iA:
undetectable		 5dzkF-3i1iA:
20.63
5dzkT-3i1iA:
0.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		4 PHE A 224
SER A 266
ALA A 267
LEU A 299
 None
 1.18A 5dzkF-3kd6A:
undetectable
5dzkT-3kd6A:
undetectable		 5dzkF-3kd6A:
22.44
5dzkT-3kd6A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 SER B 148
HIS B 133
LEU B  61
LEU B  62
 None
 1.16A 5dzkF-3mm5B:
undetectable
5dzkT-3mm5B:
undetectable		 5dzkF-3mm5B:
18.45
5dzkT-3mm5B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocr CLASS II
ALDOLASE/ADDUCIN
DOMAIN PROTEIN

(Pseudomonas
savastanoi) 		PF00596
(Aldolase_II) 		4 SER A  57
ALA A  58
HIS A 110
LEU A 124
 None
 1.14A 5dzkF-3ocrA:
undetectable
5dzkT-3ocrA:
undetectable		 5dzkF-3ocrA:
22.76
5dzkT-3ocrA:
1.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 130
MET A 256
LEU A 191
LEU A 192
 None
 1.05A 5dzkF-3oukA:
undetectable
5dzkT-3oukA:
undetectable		 5dzkF-3oukA:
23.02
5dzkT-3oukA:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		4 PHE A 248
SER A 144
ALA A 143
HIS A 101
 None
NAD  A1385 ( 4.9A)
None
None
 1.20A 5dzkF-3ox4A:
undetectable
5dzkT-3ox4A:
undetectable		 5dzkF-3ox4A:
21.79
5dzkT-3ox4A:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rms UNCHARACTERIZED
PROTEIN

(Saccharomonospora
viridis) 		PF16827
(zf-HC3) 		4 ALA A  78
PRO A  57
LEU A  91
LEU A  87
 None
 0.83A 5dzkF-3rmsA:
undetectable
5dzkT-3rmsA:
undetectable		 5dzkF-3rmsA:
18.60
5dzkT-3rmsA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Mus musculus) 		PF04389
(Peptidase_M28) 		4 SER A  87
ALA A  88
PRO A  73
LEU A  75
 None
 1.21A 5dzkF-3si1A:
undetectable
5dzkT-3si1A:
undetectable		 5dzkF-3si1A:
22.42
5dzkT-3si1A:
0.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txv PROBABLE TAGATOSE
6-PHOSPHATE KINASE

(Sinorhizobium
meliloti) 		PF08013
(Tagatose_6_P_K) 		4 PRO A  98
MET A 134
LEU A  96
LEU A 155
 None
 1.05A 5dzkF-3txvA:
undetectable
5dzkT-3txvA:
undetectable		 5dzkF-3txvA:
19.38
5dzkT-3txvA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 ALA A 289
PRO A 370
LEU A 372
LEU A 359
 None
 0.86A 5dzkF-3v4cA:
3.0
5dzkT-3v4cA:
undetectable		 5dzkF-3v4cA:
19.92
5dzkT-3v4cA:
0.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL

(Bos taurus) 		PF01597
(GCV_H) 		4 PHE A  52
SER A  38
ALA A  54
PRO A  40
 None
 0.93A 5dzkF-3wdnA:
undetectable
5dzkT-3wdnA:
undetectable		 5dzkF-3wdnA:
21.40
5dzkT-3wdnA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwi PHYTOCHROME-LIKE
PROTEIN CPH2

(Synechocystis
sp.) 		PF00360
(PHY)
PF01590
(GAF) 		4 SER A 411
ALA A 410
PRO A 312
LEU A 342
 None
 0.99A 5dzkF-4bwiA:
undetectable
5dzkT-4bwiA:
undetectable		 5dzkF-4bwiA:
21.83
5dzkT-4bwiA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 PHE A 121
MET A  66
LEU A 119
LEU A 118
 None
 1.10A 5dzkF-4byfA:
undetectable
5dzkT-4byfA:
undetectable		 5dzkF-4byfA:
15.66
5dzkT-4byfA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 SER A 754
ALA A 757
HIS A 782
LEU A 955
 None
 0.94A 5dzkF-4cakA:
undetectable
5dzkT-4cakA:
undetectable		 5dzkF-4cakA:
12.32
5dzkT-4cakA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 311
ALA A 310
HIS A 275
LEU A 168
 None
 1.03A 5dzkF-4ewpA:
undetectable
5dzkT-4ewpA:
undetectable		 5dzkF-4ewpA:
21.31
5dzkT-4ewpA:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE

(Mycobacterium
sp. JLS) 		PF04471
(Mrr_cat) 		4 PHE A 157
ALA A 182
HIS A 142
PRO A 155
 None
 1.01A 5dzkF-4f0qA:
undetectable
5dzkT-4f0qA:
undetectable		 5dzkF-4f0qA:
18.64
5dzkT-4f0qA:
0.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40) 		4 PHE B 281
SER B 263
ALA B 262
HIS B 244
 None
 1.02A 5dzkF-4g56B:
undetectable
5dzkT-4g56B:
undetectable		 5dzkF-4g56B:
21.88
5dzkT-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbm CURM
SULFOTRANSFERASE

(Moorea
producens) 		PF13469
(Sulfotransfer_3) 		4 SER A  57
ALA A  50
PRO A  59
MET A 253
 None
 1.14A 5dzkF-4gbmA:
undetectable
5dzkT-4gbmA:
undetectable		 5dzkF-4gbmA:
20.99
5dzkT-4gbmA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963

(Streptomyces
coelicolor) 		no annotation 4 PHE B 390
PRO B 371
LEU B 389
LEU B 388
 HEM  B 501 (-3.9A)
None
None
HEM  B 501 ( 4.1A)
 0.98A 5dzkF-4gt2B:
undetectable
5dzkT-4gt2B:
undetectable		 5dzkF-4gt2B:
19.24
5dzkT-4gt2B:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwb PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA 3

(Sinorhizobium
meliloti) 		PF01625
(PMSR) 		4 SER A  92
ALA A  93
HIS A  74
LEU A  67
 None
 1.21A 5dzkF-4gwbA:
undetectable
5dzkT-4gwbA:
undetectable		 5dzkF-4gwbA:
22.57
5dzkT-4gwbA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7y DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 4 PHE A  60
ALA A  45
PRO A  13
LEU A  17
 None
 1.20A 5dzkF-4h7yA:
undetectable
5dzkT-4h7yA:
undetectable		 5dzkF-4h7yA:
24.66
5dzkT-4h7yA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		4 SER A 198
ALA A 197
LEU A 228
LEU A 232
 None
None
EDO  A 304 (-4.7A)
None
 1.14A 5dzkF-4imdA:
undetectable
5dzkT-4imdA:
undetectable		 5dzkF-4imdA:
23.29
5dzkT-4imdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		4 PHE A 251
MET A 263
LEU A 249
LEU A 252
 None
 1.19A 5dzkF-4j72A:
undetectable
5dzkT-4j72A:
undetectable		 5dzkF-4j72A:
21.51
5dzkT-4j72A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 SER A 101
ALA A 122
PRO A  49
LEU A  44
 None
 1.07A 5dzkF-4mrqA:
undetectable
5dzkT-4mrqA:
undetectable		 5dzkF-4mrqA:
19.43
5dzkT-4mrqA:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 ALA A 207
PRO A 240
LEU A 252
LEU A 256
 None
 0.97A 5dzkF-4o1oA:
undetectable
5dzkT-4o1oA:
undetectable		 5dzkF-4o1oA:
15.46
5dzkT-4o1oA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 SER A  21
ALA A  22
LEU A  14
LEU A  13
 None
 1.02A 5dzkF-4pv4A:
undetectable
5dzkT-4pv4A:
undetectable		 5dzkF-4pv4A:
18.49
5dzkT-4pv4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		4 PHE A 173
SER A 120
ALA A 123
PRO A 155
 None
 0.95A 5dzkF-4q22A:
undetectable
5dzkT-4q22A:
undetectable		 5dzkF-4q22A:
20.51
5dzkT-4q22A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 PRO A  76
MET A 273
LEU A  74
LEU A  66
 None
 1.05A 5dzkF-4qtsA:
undetectable
5dzkT-4qtsA:
undetectable		 5dzkF-4qtsA:
20.10
5dzkT-4qtsA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raa PUTATIVE EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF17170
(DUF5128) 		4 PHE A 253
PRO A 249
LEU A 251
LEU A 254
 None
 1.13A 5dzkF-4raaA:
undetectable
5dzkT-4raaA:
undetectable		 5dzkF-4raaA:
22.79
5dzkT-4raaA:
3.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2

(Mycobacterium
tuberculosis) 		PF00574
(CLP_protease) 		6 PHE A  83
SER A 110
ALA A 111
HIS A 135
PRO A 137
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 (-3.8A)
ZIL  A 301 ( 2.9A)
 0.46A 5dzkF-4u0gA:
27.4
5dzkT-4u0gA:
undetectable		 5dzkF-4u0gA:
100.00
5dzkT-4u0gA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w79 PROTEIN N-TERMINAL
GLUTAMINE
AMIDOHYDROLASE

(Homo sapiens) 		PF09764
(Nt_Gln_amidase) 		4 PHE A  94
SER A  15
ALA A  14
LEU A  84
 None
 0.98A 5dzkF-4w79A:
undetectable
5dzkT-4w79A:
undetectable		 5dzkF-4w79A:
19.91
5dzkT-4w79A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ALA A 635
PRO A 638
LEU A 647
LEU A 644
 None
EDO  A 721 (-4.2A)
None
EDO  A 721 ( 4.8A)
 1.04A 5dzkF-4wd1A:
undetectable
5dzkT-4wd1A:
undetectable		 5dzkF-4wd1A:
15.50
5dzkT-4wd1A:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A 611
ALA A 613
HIS A 618
LEU A 540
 None
 1.16A 5dzkF-4y07A:
undetectable
5dzkT-4y07A:
undetectable		 5dzkF-4y07A:
20.95
5dzkT-4y07A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Yersinia pestis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 278
ALA A 277
HIS A 243
LEU A 142
 None
None
SCY  A 112 ( 3.7A)
None
 0.97A 5dzkF-4z19A:
undetectable
5dzkT-4z19A:
undetectable		 5dzkF-4z19A:
22.57
5dzkT-4z19A:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		4 SER A 248
ALA A 249
PRO A 313
LEU A 308
 None
 1.13A 5dzkF-4z43A:
undetectable
5dzkT-4z43A:
undetectable		 5dzkF-4z43A:
18.55
5dzkT-4z43A:
0.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 SER A1005
PRO A1248
LEU A1001
LEU A 998
 None
 1.01A 5dzkF-5amqA:
undetectable
5dzkT-5amqA:
undetectable		 5dzkF-5amqA:
6.74
5dzkT-5amqA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 SER A 164
ALA A 163
LEU A 222
LEU A 219
 None
 0.99A 5dzkF-5dkuA:
undetectable
5dzkT-5dkuA:
undetectable		 5dzkF-5dkuA:
14.93
5dzkT-5dkuA:
1.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum) 		PF00232
(Glyco_hydro_1) 		4 PHE A 168
ALA A 243
HIS A 309
LEU A 173
 None
 1.14A 5dzkF-5dt5A:
2.1
5dzkT-5dt5A:
undetectable		 5dzkF-5dt5A:
21.02
5dzkT-5dt5A:
0.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 PHE C 132
SER C  83
LEU C 134
LEU C 133
 None
 1.07A 5dzkF-5dwzC:
undetectable
5dzkT-5dwzC:
undetectable		 5dzkF-5dwzC:
21.01
5dzkT-5dwzC:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyr VIRULENCE-ASSOCIATED
PROTEIN D

(Xylella
fastidiosa) 		PF09827
(CRISPR_Cas2) 		4 PHE A  92
ALA A  90
HIS A  37
LEU A  84
 None
 1.08A 5dzkF-5dyrA:
2.4
5dzkT-5dyrA:
undetectable		 5dzkF-5dyrA:
22.88
5dzkT-5dyrA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		4 PHE A 171
SER A 122
ALA A 125
LEU A 169
 MPG  A 617 ( 4.5A)
None
None
5TR  A 681 ( 4.3A)
 1.06A 5dzkF-5f15A:
undetectable
5dzkT-5f15A:
undetectable		 5dzkF-5f15A:
16.67
5dzkT-5f15A:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 PHE B1197
SER B1144
ALA B1147
PRO B1179
 None
FMT  B4007 (-4.8A)
None
None
 0.94A 5dzkF-5gztB:
1.6
5dzkT-5gztB:
undetectable		 5dzkF-5gztB:
11.94
5dzkT-5gztB:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 PHE A 230
ALA A 202
LEU A  79
LEU A  80
 None
 1.06A 5dzkF-5jxkA:
undetectable
5dzkT-5jxkA:
undetectable		 5dzkF-5jxkA:
17.41
5dzkT-5jxkA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY

(Thermomonospora
curvata) 		PF04261
(Dyp_perox) 		4 PHE A 348
PRO A 329
LEU A 347
LEU A 346
 HEM  A 501 (-3.9A)
None
None
HEM  A 501 ( 4.3A)
 0.88A 5dzkF-5jxuA:
undetectable
5dzkT-5jxuA:
undetectable		 5dzkF-5jxuA:
20.68
5dzkT-5jxuA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mal LIPASE

(Streptomyces
rimosus) 		PF13472
(Lipase_GDSL_2) 		4 SER A  41
ALA A  40
HIS A  42
LEU A 227
 None
 1.04A 5dzkF-5malA:
2.2
5dzkT-5malA:
undetectable		 5dzkF-5malA:
23.20
5dzkT-5malA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		4 PHE A 390
PRO A 371
LEU A 389
LEU A 388
 HEM  A 901 (-3.8A)
None
None
HEM  A 901 ( 4.1A)
 0.99A 5dzkF-5mapA:
undetectable
5dzkT-5mapA:
undetectable		 5dzkF-5mapA:
22.01
5dzkT-5mapA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2i REDUCED COENZYME
F420:NADP
OXIDOREDUCTASE

(Thermobifida
fusca) 		PF03807
(F420_oxidored) 		4 SER A 132
ALA A 133
LEU A 201
LEU A 173
 None
 1.09A 5dzkF-5n2iA:
undetectable
5dzkT-5n2iA:
undetectable		 5dzkF-5n2iA:
21.65
5dzkT-5n2iA:
1.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyw PROTEASOME SUBUNIT

(Yersinia
bercovieri) 		no annotation 4 PHE A 128
ALA A 139
LEU A 115
LEU A 116
 None
 1.15A 5dzkF-5nywA:
undetectable
5dzkT-5nywA:
undetectable		 5dzkF-5nywA:
22.71
5dzkT-5nywA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00397
(WW)
PF00632
(HECT) 		4 PHE A 611
ALA A 613
HIS A 618
LEU A 540
 None
 1.15A 5dzkF-5tj7A:
undetectable
5dzkT-5tj7A:
undetectable		 5dzkF-5tj7A:
19.46
5dzkT-5tj7A:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN

(Arthrospira
maxima) 		PF02136
(NTF2)
PF09150
(Carot_N) 		4 PHE A 301
ALA A 220
LEU A 294
LEU A 293
 None
 1.02A 5dzkF-5ui2A:
undetectable
5dzkT-5ui2A:
undetectable		 5dzkF-5ui2A:
21.34
5dzkT-5ui2A:
0.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF13401
(AAA_22)
PF14630
(ORC5_C) 		4 PHE E 390
SER E 335
ALA E 334
LEU E 387
 None
 0.96A 5dzkF-5v8fE:
undetectable
5dzkT-5v8fE:
undetectable		 5dzkF-5v8fE:
18.94
5dzkT-5v8fE:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE

(Streptococcus
pneumoniae) 		no annotation 4 PHE A 363
ALA A 365
HIS A 261
LEU A 359
 None
HMG  A 500 (-3.3A)
None
None
 1.11A 5dzkF-5wpkA:
undetectable
5dzkT-5wpkA:
undetectable		 5dzkF-5wpkA:
undetectable
5dzkT-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xlk FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Serratia
marcescens) 		PF07195
(FliD_C)
PF07196
(Flagellin_IN) 		4 ALA A 111
MET A 219
LEU A 120
LEU A 203
 None
 1.21A 5dzkF-5xlkA:
undetectable
5dzkT-5xlkA:
undetectable		 5dzkF-5xlkA:
24.59
5dzkT-5xlkA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 4 ALA 4 403
PRO 4 533
LEU 4 511
LEU 4 508
 None
 0.87A 5dzkF-5zvs4:
undetectable
5dzkT-5zvs4:
undetectable		 5dzkF-5zvs4:
undetectable
5dzkT-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azi D-ALANYL-D-ALANINE
ENDOPEPTIDASE

(Enterobacter
cloacae) 		PF00768
(Peptidase_S11) 		4 SER A 174
MET A 259
LEU A 182
LEU A 183
 None
 1.06A 5dzkF-6aziA:
undetectable
5dzkT-6aziA:
undetectable		 5dzkF-6aziA:
21.63
5dzkT-6aziA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4m MONOTREME LACTATION
PROTEIN

(Ornithorhynchus
anatinus) 		no annotation 4 ALA A  20
PRO A  31
LEU A  33
LEU A  62
 None
 0.76A 5dzkF-6b4mA:
undetectable
5dzkT-6b4mA:
undetectable		 5dzkF-6b4mA:
undetectable
5dzkT-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON

(Streptomyces
fradiae) 		no annotation 4 PHE A 154
ALA A 127
LEU A 160
LEU A 159
 None
 1.20A 5dzkF-6cblA:
undetectable
5dzkT-6cblA:
undetectable		 5dzkF-6cblA:
undetectable
5dzkT-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2d FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIP
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIR

(Salmonella
enterica;
Salmonella
enterica) 		no annotation
no annotation 		4 SER F  34
HIS F 143
MET F 134
LEU A 179
 None
 1.08A 5dzkF-6f2dF:
undetectable
5dzkT-6f2dF:
undetectable		 5dzkF-6f2dF:
undetectable
5dzkT-6f2dF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A  62
HIS A  65
PRO A  38
LEU A  58
 None
 1.20A 5dzkF-6f91A:
undetectable
5dzkT-6f91A:
undetectable		 5dzkF-6f91A:
undetectable
5dzkT-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffl MALTOSE/MALTODEXTRIN
TRANSPORT PERMEASE
HOMOLOGUE

(Bdellovibrio
bacteriovorus) 		no annotation 4 SER A 331
ALA A 332
HIS A 115
LEU A 310
 None
 1.12A 5dzkF-6fflA:
undetectable
5dzkT-6fflA:
undetectable		 5dzkF-6fflA:
undetectable
5dzkT-6fflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fks -

(-) 		no annotation 4 SER A  34
ALA A  33
LEU A  94
LEU A  23
 None
 0.93A 5dzkF-6fksA:
undetectable
5dzkT-6fksA:
undetectable		 5dzkF-6fksA:
undetectable
5dzkT-6fksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 4 PHE L 335
SER L 250
ALA L 333
LEU L 339
 None
 1.20A 5dzkF-6g2jL:
undetectable
5dzkT-6g2jL:
undetectable		 5dzkF-6g2jL:
undetectable
5dzkT-6g2jL:
undetectable