SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_S_BEZS801_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8q BROMOPEROXIDASE A1

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		4 SER A  94
HIS A 252
MET A 125
LEU A 143
 None
 1.08A 5dzke-1a8qA:
0.6
5dzks-1a8qA:
undetectable		 5dzke-1a8qA:
20.62
5dzks-1a8qA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A 625
SER A 631
HIS A 632
LEU A 699
 None
 1.27A 5dzke-1d5fA:
undetectable
5dzks-1d5fA:
undetectable		 5dzke-1d5fA:
23.18
5dzks-1d5fA:
0.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		4 SER A 314
HIS A 315
LEU A 296
LEU A 307
 None
 1.10A 5dzke-1eb3A:
0.8
5dzks-1eb3A:
undetectable		 5dzke-1eb3A:
22.32
5dzks-1eb3A:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		4 SER A1284
HIS A1271
MET A1206
LEU A1218
 None
 1.05A 5dzke-1eg7A:
0.7
5dzks-1eg7A:
undetectable		 5dzke-1eg7A:
17.57
5dzks-1eg7A:
1.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		4 PHE A  31
SER A  35
LEU A 120
LEU A  29
 None
 1.30A 5dzke-1ibqA:
undetectable
5dzks-1ibqA:
undetectable		 5dzke-1ibqA:
19.29
5dzks-1ibqA:
0.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		4 PHE A  32
SER A  36
LEU A 121
LEU A  30
 None
 1.32A 5dzke-1izeA:
0.0
5dzks-1izeA:
undetectable		 5dzke-1izeA:
20.11
5dzks-1izeA:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		4 PHE A 121
SER A  35
LEU A  30
LEU A  29
 None
 1.00A 5dzke-1mppA:
undetectable
5dzks-1mppA:
undetectable		 5dzke-1mppA:
20.65
5dzks-1mppA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 PHE A 305
SER A 310
HIS A 311
LEU A 307
 None
 0.93A 5dzke-1muuA:
2.9
5dzks-1muuA:
undetectable		 5dzke-1muuA:
18.88
5dzks-1muuA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 PHE A 372
SER A 345
LEU A 347
LEU A 353
 None
 1.32A 5dzke-1mz5A:
undetectable
5dzks-1mz5A:
undetectable		 5dzke-1mz5A:
16.33
5dzks-1mz5A:
1.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrf REGULATORY PROTEIN
BLAR1

(Bacillus
licheniformis) 		PF00905
(Transpeptidase) 		4 PHE A 407
SER A 473
LEU A 411
LEU A 410
 None
 1.03A 5dzke-1nrfA:
undetectable
5dzks-1nrfA:
undetectable		 5dzke-1nrfA:
22.18
5dzks-1nrfA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8d GDNF FAMILY RECEPTOR
ALPHA 1

(Rattus
norvegicus) 		PF02351
(GDNF) 		4 PHE A 328
SER A 318
LEU A 326
LEU A 329
 None
 1.35A 5dzke-1q8dA:
undetectable
5dzks-1q8dA:
undetectable		 5dzke-1q8dA:
22.10
5dzks-1q8dA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae;
Burkholderia
glumae) 		PF00561
(Abhydrolase_1)
no annotation 		4 HIS E 285
MET E 254
LEU D 167
LEU D 164
 None
 1.25A 5dzke-1qgeE:
undetectable
5dzks-1qgeE:
undetectable		 5dzke-1qgeE:
19.05
5dzks-1qgeE:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae) 		no annotation 4 HIS B 285
MET B 254
LEU B 167
LEU B 164
 None
 1.30A 5dzke-1tahB:
2.6
5dzks-1tahB:
undetectable		 5dzke-1tahB:
21.78
5dzks-1tahB:
0.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlj HYPOTHETICAL UPF0130
PROTEIN SSO0622

(Sulfolobus
solfataricus) 		PF02676
(TYW3) 		4 PHE A  33
MET A 184
LEU A  31
LEU A  34
 None
 1.22A 5dzke-1tljA:
undetectable
5dzks-1tljA:
undetectable		 5dzke-1tljA:
19.92
5dzks-1tljA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 PHE A 424
HIS A 252
MET A 333
LEU A 325
 None
 1.20A 5dzke-1v5cA:
undetectable
5dzks-1v5cA:
undetectable		 5dzke-1v5cA:
21.26
5dzks-1v5cA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 PHE A 424
MET A 333
LEU A 420
LEU A 325
 None
 1.31A 5dzke-1v5cA:
undetectable
5dzks-1v5cA:
undetectable		 5dzke-1v5cA:
21.26
5dzks-1v5cA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 SER A 268
HIS A 536
MET A 570
LEU A 263
 None
 1.13A 5dzke-1we5A:
undetectable
5dzks-1we5A:
undetectable		 5dzke-1we5A:
13.64
5dzks-1we5A:
0.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		4 PHE A 159
SER A 205
HIS A 187
LEU A 161
 None
 1.27A 5dzke-1zq9A:
undetectable
5dzks-1zq9A:
undetectable		 5dzke-1zq9A:
23.24
5dzks-1zq9A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5e PROTEIN
DISULFIDE-ISOMERASE

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 PHE A  42
SER A  48
HIS A  49
LEU A  37
 None
 1.02A 5dzke-2b5eA:
undetectable
5dzks-2b5eA:
undetectable		 5dzke-2b5eA:
18.05
5dzks-2b5eA:
0.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00121
(TIM) 		4 PHE A  43
MET A  65
LEU A  85
LEU A  46
 None
 1.22A 5dzke-2btmA:
undetectable
5dzks-2btmA:
undetectable		 5dzke-2btmA:
23.74
5dzks-2btmA:
1.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		4 PHE A 159
SER A 176
LEU A 129
LEU A 158
 None
 1.12A 5dzke-2dy0A:
undetectable
5dzks-2dy0A:
undetectable		 5dzke-2dy0A:
24.43
5dzks-2dy0A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		4 PHE A 503
SER A 325
LEU A 498
LEU A 499
 None
 1.28A 5dzke-2gjmA:
undetectable
5dzks-2gjmA:
undetectable		 5dzke-2gjmA:
15.38
5dzks-2gjmA:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		4 PHE A 282
SER A 212
HIS A 188
LEU A 285
 None
None
DFP  A1189 ( 4.8A)
None
 1.02A 5dzke-2gzsA:
undetectable
5dzks-2gzsA:
undetectable		 5dzke-2gzsA:
20.36
5dzks-2gzsA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 PHE A 652
HIS A 692
LEU A 673
LEU A 672
 None
 1.22A 5dzke-2iutA:
undetectable
5dzks-2iutA:
undetectable		 5dzke-2iutA:
17.47
5dzks-2iutA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA

(Homo sapiens) 		PF00076
(RRM_1) 		4 PHE B 161
SER B 158
LEU B 127
LEU B 125
 G  A   3 ( 3.4A)
None
None
None
 1.11A 5dzke-2kxnB:
undetectable
5dzks-2kxnB:
undetectable		 5dzke-2kxnB:
20.19
5dzks-2kxnB:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 PHE A 393
SER A 350
LEU A 334
LEU A 395
 None
 1.08A 5dzke-2nsmA:
undetectable
5dzks-2nsmA:
undetectable		 5dzke-2nsmA:
18.47
5dzks-2nsmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)

(Candida
albicans) 		PF01380
(SIS) 		4 SER A 569
HIS A 596
LEU A 571
LEU A 572
 None
 0.98A 5dzke-2putA:
undetectable
5dzks-2putA:
undetectable		 5dzke-2putA:
20.33
5dzks-2putA:
0.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		4 PHE A 133
SER A  41
LEU A 132
LEU A  35
 None
 1.13A 5dzke-2rmpA:
undetectable
5dzks-2rmpA:
undetectable		 5dzke-2rmpA:
20.00
5dzks-2rmpA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 PHE G1764
SER G1761
HIS G1720
LEU G1717
 None
 1.21A 5dzke-2uv8G:
0.7
5dzks-2uv8G:
undetectable		 5dzke-2uv8G:
7.39
5dzks-2uv8G:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 PHE A 545
HIS A 505
LEU A 543
LEU A 546
 None
 1.34A 5dzke-2vxoA:
undetectable
5dzks-2vxoA:
undetectable		 5dzke-2vxoA:
15.52
5dzks-2vxoA:
1.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 PHE A  32
SER A  36
LEU A 121
LEU A  30
 None
PP6  A 327 ( 4.0A)
None
None
 1.33A 5dzke-2wedA:
undetectable
5dzks-2wedA:
undetectable		 5dzke-2wedA:
18.24
5dzks-2wedA:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 PHE A 403
SER A 495
HIS A 650
LEU A 405
 None
 1.22A 5dzke-2wskA:
1.2
5dzks-2wskA:
undetectable		 5dzke-2wskA:
16.17
5dzks-2wskA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		4 PHE A 271
SER A 444
HIS A 448
LEU A 315
 None
 1.13A 5dzke-2xhgA:
undetectable
5dzks-2xhgA:
undetectable		 5dzke-2xhgA:
18.04
5dzks-2xhgA:
1.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 PHE C  16
SER C  21
LEU C  19
LEU C  45
 GOL  C1412 ( 3.4A)
None
SF4  C1413 (-4.3A)
SF4  C1413 (-4.0A)
 1.36A 5dzke-2ynmC:
2.4
5dzks-2ynmC:
undetectable		 5dzke-2ynmC:
21.82
5dzks-2ynmC:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		4 PHE A 148
SER A  46
MET A 145
LEU A 149
 None
 1.09A 5dzke-3clwA:
1.9
5dzks-3clwA:
undetectable		 5dzke-3clwA:
18.55
5dzks-3clwA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqy ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Shewanella
oneidensis) 		PF03702
(AnmK) 		4 PHE A  73
HIS A  36
LEU A  75
LEU A  72
 None
 1.08A 5dzke-3cqyA:
undetectable
5dzks-3cqyA:
undetectable		 5dzke-3cqyA:
20.60
5dzks-3cqyA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 PHE D 387
MET D 439
LEU D 413
LEU D 417
 None
 1.09A 5dzke-3dzuD:
undetectable
5dzks-3dzuD:
undetectable		 5dzke-3dzuD:
20.76
5dzks-3dzuD:
1.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e02 UNCHARACTERIZED
PROTEIN DUF849

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		4 SER A  16
HIS A  51
MET A  92
LEU A 147
 None
ZN  A 311 (-3.4A)
None
None
 1.18A 5dzke-3e02A:
2.8
5dzks-3e02A:
undetectable		 5dzke-3e02A:
23.32
5dzks-3e02A:
0.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh6 MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALF

(Escherichia
coli) 		PF00528
(BPD_transp_1)
PF14785
(MalF_P2) 		4 PHE F 281
SER F 288
LEU F 466
LEU F 467
 None
 1.25A 5dzke-3fh6F:
undetectable
5dzks-3fh6F:
undetectable		 5dzke-3fh6F:
19.65
5dzks-3fh6F:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		4 PHE A  42
SER A   9
HIS A  71
LEU A  40
 None
FMN  A 504 ( 4.7A)
FMN  A 504 (-3.8A)
None
 1.23A 5dzke-3gg0A:
2.7
5dzks-3gg0A:
undetectable		 5dzke-3gg0A:
20.96
5dzks-3gg0A:
0.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		4 PHE A 268
SER A 184
LEU A  90
LEU A  91
 None
 1.18A 5dzke-3h9pA:
undetectable
5dzks-3h9pA:
undetectable		 5dzke-3h9pA:
23.62
5dzks-3h9pA:
1.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		4 SER A 216
HIS A 228
LEU A 232
LEU A 234
 None
 1.34A 5dzke-3hheA:
undetectable
5dzks-3hheA:
undetectable		 5dzke-3hheA:
23.44
5dzks-3hheA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 PHE B 350
HIS B  27
MET B 122
LEU B 349
 None
 1.33A 5dzke-3hkzB:
undetectable
5dzks-3hkzB:
undetectable		 5dzke-3hkzB:
12.57
5dzks-3hkzB:
0.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 PHE X 478
SER X 508
LEU X 480
LEU X 612
 None
 1.22A 5dzke-3jb9X:
undetectable
5dzks-3jb9X:
undetectable		 5dzke-3jb9X:
10.02
5dzks-3jb9X:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 PHE A 341
SER A 309
LEU A 312
LEU A 339
 None
 1.12A 5dzke-3kfuA:
undetectable
5dzks-3kfuA:
undetectable		 5dzke-3kfuA:
17.87
5dzks-3kfuA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		4 PHE A1207
MET A1099
LEU A1205
LEU A1208
 None
 1.33A 5dzke-3kuqA:
undetectable
5dzks-3kuqA:
undetectable		 5dzke-3kuqA:
24.90
5dzks-3kuqA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE

(Mesorhizobium
loti) 		PF12697
(Abhydrolase_6) 		4 SER A 106
HIS A 258
LEU A 143
LEU A 140
 CL  A 279 (-2.8A)
None
None
None
 1.33A 5dzke-3kxpA:
2.2
5dzks-3kxpA:
undetectable		 5dzke-3kxpA:
20.81
5dzks-3kxpA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 SER B 148
HIS B 133
LEU B  61
LEU B  62
 None
 1.23A 5dzke-3mm5B:
undetectable
5dzks-3mm5B:
undetectable		 5dzke-3mm5B:
18.45
5dzks-3mm5B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		4 PHE A 291
SER A 288
LEU A 251
LEU A 252
 None
OAE  A 376 (-4.7A)
None
None
 1.15A 5dzke-3nfbA:
undetectable
5dzks-3nfbA:
undetectable		 5dzke-3nfbA:
22.25
5dzks-3nfbA:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa2 WBPB

(Pseudomonas
aeruginosa) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 SER A  30
HIS A  60
LEU A  72
LEU A  94
 None
 1.33A 5dzke-3oa2A:
undetectable
5dzks-3oa2A:
undetectable		 5dzke-3oa2A:
22.26
5dzks-3oa2A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py6 BETA-LACTAMASE-LIKE

(Brucella
abortus) 		PF12706
(Lactamase_B_2) 		4 PHE A 220
SER A 218
HIS A 170
LEU A 211
 None
5GP  A 303 ( 4.3A)
MN  A 301 ( 3.4A)
None
 1.24A 5dzke-3py6A:
undetectable
5dzks-3py6A:
undetectable		 5dzke-3py6A:
23.96
5dzks-3py6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 PHE A  49
HIS A  98
MET A  63
LEU A  75
 None
 1.35A 5dzke-3qlvA:
undetectable
5dzks-3qlvA:
undetectable		 5dzke-3qlvA:
20.20
5dzks-3qlvA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqq METHIONYL-TRNA
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 SER A  24
HIS A  26
LEU A 179
LEU A 178
 K  A 315 (-4.5A)
None
None
None
 1.22A 5dzke-3tqqA:
undetectable
5dzks-3tqqA:
undetectable		 5dzke-3tqqA:
23.20
5dzks-3tqqA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Vibrio cholerae) 		PF14489
(QueF)
PF14819
(QueF_N) 		4 PHE A  98
SER A 104
LEU A  35
LEU A  36
 None
 1.09A 5dzke-3uxjA:
undetectable
5dzks-3uxjA:
undetectable		 5dzke-3uxjA:
24.23
5dzks-3uxjA:
1.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2w CRISPR SYSTEM CMR
SUBUNIT CMR3

(Pyrococcus
furiosus) 		PF09700
(Cas_Cmr3) 		4 PHE B 290
SER B 287
LEU B 258
LEU B 257
 None
 1.13A 5dzke-3w2wB:
undetectable
5dzks-3w2wB:
undetectable		 5dzke-3w2wB:
19.82
5dzks-3w2wB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 PHE A 121
MET A  66
LEU A 119
LEU A 118
 None
 1.24A 5dzke-4byfA:
undetectable
5dzks-4byfA:
undetectable		 5dzke-4byfA:
15.66
5dzks-4byfA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus) 		PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel) 		4 PHE A 280
MET A 256
LEU A 209
LEU A 210
 None
 1.32A 5dzke-4d2iA:
undetectable
5dzks-4d2iA:
undetectable		 5dzke-4d2iA:
18.03
5dzks-4d2iA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc4 NITRITE TRANSPORTER
NIRC

(Salmonella
enterica) 		PF01226
(Form_Nir_trans) 		4 PHE A 205
HIS A 139
LEU A 207
LEU A 204
 None
 1.28A 5dzke-4fc4A:
undetectable
5dzks-4fc4A:
undetectable		 5dzke-4fc4A:
19.78
5dzks-4fc4A:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		4 SER A 107
HIS A 228
MET A 276
LEU A  95
 None
 1.36A 5dzke-4hxqA:
undetectable
5dzks-4hxqA:
undetectable		 5dzke-4hxqA:
22.19
5dzks-4hxqA:
0.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		4 PHE A 251
MET A 263
LEU A 249
LEU A 252
 None
 1.20A 5dzke-4j72A:
undetectable
5dzks-4j72A:
undetectable		 5dzke-4j72A:
21.51
5dzks-4j72A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 SER A 138
HIS A 277
MET A 228
LEU A 187
 PLM  A 400 (-2.9A)
None
PLM  A 400 ( 4.8A)
None
 1.33A 5dzke-4jatA:
undetectable
5dzks-4jatA:
undetectable		 5dzke-4jatA:
24.58
5dzks-4jatA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF13646
(HEAT_2) 		4 PHE A 113
SER A 148
MET A 177
LEU A 114
 None
 1.34A 5dzke-4l7mA:
undetectable
5dzks-4l7mA:
undetectable		 5dzke-4l7mA:
21.50
5dzks-4l7mA:
0.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 SER A 343
HIS A 291
LEU A 376
LEU A 380
 None
 1.25A 5dzke-4mx2A:
undetectable
5dzks-4mx2A:
undetectable		 5dzke-4mx2A:
19.05
5dzks-4mx2A:
1.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oiy PROTEIN TRANSPORT
PROTEIN SEC7

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		4 PHE A1002
SER A 958
MET A 975
LEU A 998
 None
 1.20A 5dzke-4oiyA:
undetectable
5dzks-4oiyA:
undetectable		 5dzke-4oiyA:
24.89
5dzks-4oiyA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii) 		PF12697
(Abhydrolase_6) 		4 PHE A 173
SER A 144
HIS A 298
LEU A 181
 None
15P  A 401 (-3.6A)
None
None
 1.22A 5dzke-4opmA:
2.1
5dzks-4opmA:
undetectable		 5dzke-4opmA:
21.02
5dzks-4opmA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Homo sapiens) 		PF12796
(Ank_2) 		4 PHE A 451
SER A 457
LEU A 453
LEU A 450
 None
 1.18A 5dzke-4ot9A:
2.7
5dzks-4ot9A:
undetectable		 5dzke-4ot9A:
20.95
5dzks-4ot9A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkl BROMODOMAIN FACTOR 2

(Trypanosoma
brucei) 		PF00439
(Bromodomain) 		4 PHE A  31
SER A  98
LEU A  25
LEU A  22
 None
 1.36A 5dzke-4pklA:
undetectable
5dzks-4pklA:
undetectable		 5dzke-4pklA:
22.90
5dzks-4pklA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 PHE B 506
SER B 470
LEU B 449
LEU B 507
 None
 1.21A 5dzke-4q4aB:
2.9
5dzks-4q4aB:
undetectable		 5dzke-4q4aB:
15.47
5dzks-4q4aB:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7l UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 PHE A 506
SER A 470
LEU A 449
LEU A 507
 None
 1.08A 5dzke-4q7lA:
2.1
5dzks-4q7lA:
undetectable		 5dzke-4q7lA:
22.51
5dzks-4q7lA:
1.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		4 PHE A 679
SER A 667
LEU A 677
LEU A 680
 None
None
CLA  A9012 ( 4.0A)
CLA  A9012 (-4.1A)
 1.22A 5dzke-4rkuA:
undetectable
5dzks-4rkuA:
undetectable		 5dzke-4rkuA:
14.06
5dzks-4rkuA:
1.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2

(Mycobacterium
tuberculosis) 		PF00574
(CLP_protease) 		4 PHE A  83
SER A 110
HIS A 135
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 ( 2.9A)
 0.50A 5dzke-4u0gA:
27.6
5dzks-4u0gA:
undetectable		 5dzke-4u0gA:
100.00
5dzks-4u0gA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u89 PHOSPHOPANTETHEINYL
TRANSFERASE PPTT

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		4 PHE A 153
SER A 130
LEU A 126
LEU A 121
 None
 1.34A 5dzke-4u89A:
undetectable
5dzks-4u89A:
undetectable		 5dzke-4u89A:
22.14
5dzks-4u89A:
1.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux8 GDNF FAMILY RECEPTOR
ALPHA-1

(Rattus
norvegicus) 		PF02351
(GDNF) 		4 PHE C 328
SER C 318
LEU C 326
LEU C 329
 None
 1.28A 5dzke-4ux8C:
undetectable
5dzks-4ux8C:
undetectable		 5dzke-4ux8C:
18.75
5dzks-4ux8C:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 SER A 286
HIS A 273
LEU A 314
LEU A 342
 None
 1.25A 5dzke-4yyfA:
2.4
5dzks-4yyfA:
undetectable		 5dzke-4yyfA:
20.70
5dzks-4yyfA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8z UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 PHE A 207
HIS A 197
LEU A 183
LEU A 182
 None
 1.22A 5dzke-4z8zA:
2.1
5dzks-4z8zA:
undetectable		 5dzke-4z8zA:
22.43
5dzks-4z8zA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 SER A 283
HIS A 270
MET A 205
LEU A 217
 None
 0.98A 5dzke-5a4jA:
undetectable
5dzks-5a4jA:
undetectable		 5dzke-5a4jA:
18.66
5dzks-5a4jA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 SER A 282
HIS A 269
MET A 204
LEU A 216
 None
 0.93A 5dzke-5a5gA:
undetectable
5dzks-5a5gA:
undetectable		 5dzke-5a5gA:
15.89
5dzks-5a5gA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt1 HAT1-INTERACTING
FACTOR 1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A  38
MET A  74
LEU A  32
LEU A  33
 None
 1.15A 5dzke-5bt1A:
undetectable
5dzks-5bt1A:
undetectable		 5dzke-5bt1A:
20.88
5dzks-5bt1A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu9 BETA-N-ACETYLHEXOSAM
INIDASE

(Beutenbergia
cavernae) 		PF00933
(Glyco_hydro_3) 		4 PHE A  83
SER A 339
MET A 376
LEU A 365
 None
 1.31A 5dzke-5bu9A:
1.7
5dzks-5bu9A:
undetectable		 5dzke-5bu9A:
20.52
5dzks-5bu9A:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c78 ATP-DRIVEN FLIPPASE
PGLK

(Campylobacter
jejuni) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 PHE A 150
SER A  24
LEU A 152
LEU A 153
 None
 1.38A 5dzke-5c78A:
undetectable
5dzks-5c78A:
undetectable		 5dzke-5c78A:
16.02
5dzks-5c78A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 PHE A 316
SER A 272
HIS A 236
LEU A 224
 None
NA  A 504 (-3.0A)
NA  A 504 (-4.5A)
None
 1.33A 5dzke-5ce6A:
undetectable
5dzks-5ce6A:
undetectable		 5dzke-5ce6A:
19.54
5dzks-5ce6A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efv PHI ETA ORF 56-LIKE
PROTEIN

(Staphylococcus
virus 11) 		no annotation 4 SER A 226
MET A 253
LEU A 189
LEU A 202
 None
 1.11A 5dzke-5efvA:
undetectable
5dzks-5efvA:
undetectable		 5dzke-5efvA:
16.56
5dzks-5efvA:
0.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 PHE A 214
HIS A 282
LEU A 257
LEU A 216
 None
 1.31A 5dzke-5h2tA:
2.0
5dzks-5h2tA:
undetectable		 5dzke-5h2tA:
15.47
5dzks-5h2tA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 PHE A  34
SER A  38
LEU A 125
LEU A  32
 None
 1.33A 5dzke-5hctA:
undetectable
5dzks-5hctA:
undetectable		 5dzke-5hctA:
19.76
5dzks-5hctA:
1.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij6 LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 PHE A 210
MET A   1
LEU A 205
LEU A 206
 None
 1.26A 5dzke-5ij6A:
undetectable
5dzks-5ij6A:
undetectable		 5dzke-5ij6A:
21.43
5dzks-5ij6A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kj8 SYNAPTOTAGMIN-1

(Rattus
norvegicus) 		PF00168
(C2) 		4 SER E 148
MET E 226
LEU E 159
LEU E 158
 None
 1.33A 5dzke-5kj8E:
undetectable
5dzks-5kj8E:
undetectable		 5dzke-5kj8E:
21.20
5dzks-5kj8E:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12

(Gallus gallus) 		PF01007
(IRK) 		4 PHE A  97
MET A 161
LEU A  99
LEU A  96
 None
 1.37A 5dzke-5kumA:
undetectable
5dzks-5kumA:
undetectable		 5dzke-5kumA:
21.22
5dzks-5kumA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRP46

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 SER J 325
HIS J 307
LEU J 304
LEU J 341
 None
 1.28A 5dzke-5lj3J:
undetectable
5dzks-5lj3J:
undetectable		 5dzke-5lj3J:
18.28
5dzks-5lj3J:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyj ANBU

(Hyphomicrobium
sp. MC1) 		PF00227
(Proteasome) 		4 PHE A   6
MET A 177
LEU A  12
LEU A   8
 None
 1.20A 5dzke-5nyjA:
undetectable
5dzks-5nyjA:
undetectable		 5dzke-5nyjA:
23.66
5dzks-5nyjA:
1.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L25

(Mycolicibacterium
smegmatis) 		PF01386
(Ribosomal_L25p)
PF14693
(Ribosomal_TL5_C) 		4 PHE W  54
SER W  60
HIS W  61
LEU W  11
 None
 1.01A 5dzke-5o60W:
undetectable
5dzks-5o60W:
undetectable		 5dzke-5o60W:
19.38
5dzks-5o60W:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 PHE A  34
SER A  38
LEU A 125
LEU A  32
 None
 1.34A 5dzke-5p60A:
undetectable
5dzks-5p60A:
undetectable		 5dzke-5p60A:
20.41
5dzks-5p60A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN

(Thermoactinomyces
vulgaris) 		PF00668
(Condensation) 		4 PHE A 953
SER A 873
LEU A 982
LEU A 983
 None
 1.35A 5dzke-5t3eA:
undetectable
5dzks-5t3eA:
undetectable		 5dzke-5t3eA:
21.71
5dzks-5t3eA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vto BLASTICIDIN M

(Streptomyces
griseochromogenes) 		no annotation 4 SER A  99
HIS A 103
LEU A 118
LEU A 120
 None
 1.37A 5dzke-5vtoA:
undetectable
5dzks-5vtoA:
undetectable		 5dzke-5vtoA:
undetectable
5dzks-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S4

(Trichomonas
vaginalis) 		PF00900
(Ribosomal_S4e)
PF01479
(S4)
PF08071
(RS4NT)
PF16121
(40S_S4_C) 		4 PHE E 162
SER E 171
LEU E 123
LEU E 124
 None
 1.33A 5dzke-5xyiE:
undetectable
5dzks-5xyiE:
undetectable		 5dzke-5xyiE:
21.40
5dzks-5xyiE:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azi D-ALANYL-D-ALANINE
ENDOPEPTIDASE

(Enterobacter
cloacae) 		PF00768
(Peptidase_S11) 		4 SER A 174
MET A 259
LEU A 182
LEU A 183
 None
 1.09A 5dzke-6aziA:
undetectable
5dzks-6aziA:
undetectable		 5dzke-6aziA:
21.63
5dzks-6aziA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dg4 ULP1-LIKE SUMO
PROTEASE

(Chaetomium
thermophilum) 		no annotation 4 PHE A  96
SER A 102
HIS A 103
LEU A 111
 None
 1.32A 5dzke-6dg4A:
undetectable
5dzks-6dg4A:
undetectable		 5dzke-6dg4A:
undetectable
5dzks-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezn DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT WBP1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE G 174
SER G 154
HIS G 157
LEU G 151
 None
 1.34A 5dzke-6eznG:
undetectable
5dzks-6eznG:
undetectable		 5dzke-6eznG:
undetectable
5dzks-6eznG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2d FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIP
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIR

(Salmonella
enterica;
Salmonella
enterica) 		no annotation
no annotation 		4 SER F  34
HIS F 143
MET F 134
LEU A 179
 None
 1.03A 5dzke-6f2dF:
undetectable
5dzks-6f2dF:
undetectable		 5dzke-6f2dF:
undetectable
5dzks-6f2dF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A  62
HIS A  65
MET A 129
LEU A  58
 None
 1.37A 5dzke-6f91A:
undetectable
5dzks-6f91A:
undetectable		 5dzke-6f91A:
undetectable
5dzks-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 4 PHE L 124
MET L 252
LEU L 153
LEU L 154
 None
None
CDL  L 702 (-4.6A)
None
 1.38A 5dzke-6g2jL:
undetectable
5dzks-6g2jL:
undetectable		 5dzke-6g2jL:
undetectable
5dzks-6g2jL:
undetectable