SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_R_BEZR801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		4 SER A 209
ALA A 210
HIS A 449
LEU A 302
 None
 1.15A 5dzkd-1crlA:
0.3
5dzkr-1crlA:
undetectable		 5dzkd-1crlA:
17.18
5dzkr-1crlA:
0.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 PHE A 432
ALA A 365
PRO A 168
MET A 370
LEU A 157
 None
 1.37A 5dzkd-1dcnA:
undetectable
5dzkr-1dcnA:
undetectable		 5dzkd-1dcnA:
19.09
5dzkr-1dcnA:
1.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		4 ALA A 259
HIS A 234
LEU A 214
LEU A 215
 None
 1.12A 5dzkd-1dgmA:
2.0
5dzkr-1dgmA:
undetectable		 5dzkd-1dgmA:
21.27
5dzkr-1dgmA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		4 SER A 314
HIS A 315
LEU A 296
LEU A 307
 None
 1.06A 5dzkd-1eb3A:
1.0
5dzkr-1eb3A:
undetectable		 5dzkd-1eb3A:
22.32
5dzkr-1eb3A:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 279
ALA A 278
HIS A 244
LEU A 142
 None
None
COA  A1350 (-4.4A)
None
 1.02A 5dzkd-1eblA:
undetectable
5dzkr-1eblA:
undetectable		 5dzkd-1eblA:
21.18
5dzkr-1eblA:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eco ERYTHROCRUORIN
(CARBONMONOXY)

(Chironomus
thummi) 		PF00042
(Globin) 		4 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.96A 5dzkd-1ecoA:
undetectable
5dzkr-1ecoA:
undetectable		 5dzkd-1ecoA:
22.12
5dzkr-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		4 SER A 174
ALA A 175
HIS A 286
PRO A 178
 None
 1.08A 5dzkd-1gzvA:
undetectable
5dzkr-1gzvA:
undetectable		 5dzkd-1gzvA:
16.52
5dzkr-1gzvA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q TRPG

(Serratia
marcescens) 		PF00117
(GATase) 		4 SER B  24
ALA B  23
HIS B  26
LEU B 185
 None
 1.01A 5dzkd-1i7qB:
undetectable
5dzkr-1i7qB:
undetectable		 5dzkd-1i7qB:
24.47
5dzkr-1i7qB:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmk SURFACTIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		4 SER C  80
ALA C  81
HIS C 207
LEU C 129
 None
 1.14A 5dzkd-1jmkC:
2.9
5dzkr-1jmkC:
undetectable		 5dzkd-1jmkC:
22.92
5dzkr-1jmkC:
1.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 SER A 248
ALA A 249
HIS A 197
PRO A 184
 None
 1.18A 5dzkd-1l5jA:
undetectable
5dzkr-1l5jA:
undetectable		 5dzkd-1l5jA:
13.89
5dzkr-1l5jA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leo NUCLEOSIDE
DIPHOSPHATE KINASE

(Dictyostelium
discoideum) 		PF00334
(NDK) 		4 SER A 124
ALA A 130
HIS A 122
LEU A 136
 None
 1.19A 5dzkd-1leoA:
undetectable
5dzkr-1leoA:
undetectable		 5dzkd-1leoA:
18.89
5dzkr-1leoA:
1.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 PHE A 612
ALA A 476
HIS A 555
LEU A 613
 None
 0.94A 5dzkd-1llaA:
undetectable
5dzkr-1llaA:
undetectable		 5dzkd-1llaA:
15.40
5dzkr-1llaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 SER A 316
ALA A 315
LEU A 327
LEU A 328
 None
 0.78A 5dzkd-1mb9A:
undetectable
5dzkr-1mb9A:
undetectable		 5dzkd-1mb9A:
17.02
5dzkr-1mb9A:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 PHE A 305
SER A 310
HIS A 311
LEU A 307
 None
 1.10A 5dzkd-1muuA:
2.9
5dzkr-1muuA:
undetectable		 5dzkd-1muuA:
18.88
5dzkr-1muuA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 SER A  76
ALA A  75
HIS A  58
LEU A  95
 None
 1.15A 5dzkd-1nr0A:
undetectable
5dzkr-1nr0A:
undetectable		 5dzkd-1nr0A:
16.53
5dzkr-1nr0A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 SER A 103
ALA A  76
HIS A 180
LEU A  73
 None
 1.02A 5dzkd-1pgpA:
undetectable
5dzkr-1pgpA:
undetectable		 5dzkd-1pgpA:
17.63
5dzkr-1pgpA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg1 KIAA1579 PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		4 SER A  94
PRO A 165
LEU A 163
LEU A  98
 None
 1.15A 5dzkd-1wg1A:
undetectable
5dzkr-1wg1A:
undetectable		 5dzkd-1wg1A:
18.96
5dzkr-1wg1A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y30 HYPOTHETICAL PROTEIN
RV1155

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		4 ALA A  82
PRO A 135
LEU A  45
LEU A  46
 None
 1.17A 5dzkd-1y30A:
undetectable
5dzkr-1y30A:
undetectable		 5dzkd-1y30A:
21.30
5dzkr-1y30A:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus) 		PF13714
(PEP_mutase) 		4 PHE A  80
PRO A  78
LEU A  83
LEU A  82
 None
 1.03A 5dzkd-1zlpA:
3.5
5dzkr-1zlpA:
undetectable		 5dzkd-1zlpA:
20.74
5dzkr-1zlpA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 PHE A 477
ALA A 439
PRO A 480
LEU A 475
 None
 1.18A 5dzkd-2cfzA:
undetectable
5dzkr-2cfzA:
undetectable		 5dzkd-2cfzA:
15.73
5dzkr-2cfzA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		4 PHE A 357
PRO A 363
LEU A 359
LEU A 356
 None
 1.14A 5dzkd-2dh3A:
2.4
5dzkr-2dh3A:
undetectable		 5dzkd-2dh3A:
19.39
5dzkr-2dh3A:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		4 PHE A 159
SER A 176
LEU A 129
LEU A 158
 None
 1.20A 5dzkd-2dy0A:
undetectable
5dzkr-2dy0A:
undetectable		 5dzkd-2dy0A:
24.43
5dzkr-2dy0A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 SER A 226
ALA A 227
HIS A 471
LEU A 313
 TFC  A 600 (-1.4A)
TFC  A 600 (-3.5A)
TFC  A 600 (-4.2A)
TFC  A 600 (-4.2A)
 0.99A 5dzkd-2fj0A:
2.4
5dzkr-2fj0A:
undetectable		 5dzkd-2fj0A:
17.60
5dzkr-2fj0A:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		4 PHE A 282
SER A 212
HIS A 188
LEU A 285
 None
None
DFP  A1189 ( 4.8A)
None
 0.94A 5dzkd-2gzsA:
undetectable
5dzkr-2gzsA:
undetectable		 5dzkd-2gzsA:
20.36
5dzkr-2gzsA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		4 ALA A  29
PRO A   9
LEU A  45
LEU A  43
 None
 0.96A 5dzkd-2j3mA:
undetectable
5dzkr-2j3mA:
undetectable		 5dzkd-2j3mA:
19.01
5dzkr-2j3mA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjl PEPTIDYL-TRNA
HYDROLASE

(Vibrio cholerae) 		PF01195
(Pept_tRNA_hydro) 		4 ALA A  28
PRO A  67
LEU A  51
LEU A  65
 None
 1.13A 5dzkd-2mjlA:
undetectable
5dzkr-2mjlA:
undetectable		 5dzkd-2mjlA:
21.37
5dzkr-2mjlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npr MEROZOITE SURFACE
PROTEIN 1

(Plasmodium
vivax) 		PF12946
(EGF_MSP1_1)
PF12947
(EGF_3) 		4 PHE A  35
ALA A  45
LEU A  33
LEU A  32
 None
 0.91A 5dzkd-2nprA:
undetectable
5dzkr-2nprA:
undetectable		 5dzkd-2nprA:
13.74
5dzkr-2nprA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 SER A 169
ALA A 170
HIS A 306
LEU A 227
 4PA  A 369 (-1.8A)
4PA  A 369 (-3.2A)
4PA  A 369 (-4.8A)
None
 1.21A 5dzkd-2o7rA:
2.8
5dzkr-2o7rA:
undetectable		 5dzkd-2o7rA:
24.93
5dzkr-2o7rA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 SER A 103
ALA A  76
HIS A 179
LEU A  73
 None
 0.94A 5dzkd-2p4qA:
undetectable
5dzkr-2p4qA:
undetectable		 5dzkd-2p4qA:
17.73
5dzkr-2p4qA:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		4 ALA A 335
PRO A 153
LEU A 366
LEU A 365
 None
 1.09A 5dzkd-2pgeA:
2.1
5dzkr-2pgeA:
undetectable		 5dzkd-2pgeA:
22.65
5dzkr-2pgeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)

(Candida
albicans) 		PF01380
(SIS) 		4 SER A 569
HIS A 596
LEU A 571
LEU A 572
 None
 0.88A 5dzkd-2putA:
undetectable
5dzkr-2putA:
undetectable		 5dzkd-2putA:
20.33
5dzkr-2putA:
0.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 PHE A 240
ALA A 173
LEU A 236
LEU A 237
 EDO  A 336 ( 4.9A)
None
None
None
 1.04A 5dzkd-2r3sA:
undetectable
5dzkr-2r3sA:
undetectable		 5dzkd-2r3sA:
21.36
5dzkr-2r3sA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 SER A 272
ALA A 271
LEU A 264
LEU A 261
 CYC  A1521 ( 3.7A)
None
None
None
 1.05A 5dzkd-2veaA:
undetectable
5dzkr-2veaA:
undetectable		 5dzkd-2veaA:
18.41
5dzkr-2veaA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp0 HOBA

(Helicobacter
pylori) 		PF12163
(HobA) 		4 HIS A  43
PRO A 110
LEU A  50
LEU A  51
 None
 1.21A 5dzkd-2wp0A:
1.9
5dzkr-2wp0A:
undetectable		 5dzkd-2wp0A:
20.64
5dzkr-2wp0A:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		4 PHE A 396
ALA A 400
PRO A  47
LEU A 395
 None
 1.18A 5dzkd-2zy2A:
1.9
5dzkr-2zy2A:
undetectable		 5dzkd-2zy2A:
17.86
5dzkr-2zy2A:
1.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii) 		PF00118
(Cpn60_TCP1) 		4 PHE B 281
ALA B 301
LEU B 231
LEU B 230
 None
 1.15A 5dzkd-3aq1B:
2.1
5dzkr-3aq1B:
undetectable		 5dzkd-3aq1B:
18.84
5dzkr-3aq1B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg1 PROTEIN SEC13
HOMOLOG

(Homo sapiens) 		PF00400
(WD40) 		4 SER A 233
ALA A 232
HIS A 211
LEU A 257
 None
 1.13A 5dzkd-3bg1A:
undetectable
5dzkr-3bg1A:
undetectable		 5dzkd-3bg1A:
20.75
5dzkr-3bg1A:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ

(Vibrio
vulnificus) 		PF11612
(T2SSJ) 		4 PHE B  91
ALA B  59
LEU B  74
LEU B  75
 None
 0.94A 5dzkd-3cfiB:
undetectable
5dzkr-3cfiB:
undetectable		 5dzkd-3cfiB:
19.91
5dzkr-3cfiB:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		no annotation 4 PHE A 119
ALA A 114
PRO A  77
LEU A 191
 None
 1.06A 5dzkd-3cjiA:
undetectable
5dzkr-3cjiA:
undetectable		 5dzkd-3cjiA:
23.21
5dzkr-3cjiA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjx PROTEIN OF UNKNOWN
FUNCTION WITH A
CUPIN-LIKE FOLD

(Cupriavidus
pinatubonensis) 		no annotation 4 ALA A  51
PRO A  37
LEU A  27
LEU A  24
 None
 1.21A 5dzkd-3cjxA:
undetectable
5dzkr-3cjxA:
undetectable		 5dzkd-3cjxA:
22.67
5dzkr-3cjxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 4 SER A 145
ALA A 146
HIS A 268
LEU A  61
 SO4  A 304 ( 2.7A)
SO4  A 304 (-4.1A)
SO4  A 306 (-4.0A)
SO4  A 306 ( 4.5A)
 1.16A 5dzkd-3d0kA:
undetectable
5dzkr-3d0kA:
undetectable		 5dzkd-3d0kA:
21.36
5dzkr-3d0kA:
0.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3s L-2,4-DIAMINOBUTYRIC
ACID
ACETYLTRANSFERASE

(Bordetella
parapertussis) 		PF00583
(Acetyltransf_1) 		4 PHE A  71
ALA A  60
LEU A  62
LEU A  63
 None
 1.16A 5dzkd-3d3sA:
undetectable
5dzkr-3d3sA:
undetectable		 5dzkd-3d3sA:
23.35
5dzkr-3d3sA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR

(Shewanella
oneidensis) 		PF02661
(Fic)
PF13784
(Fic_N) 		4 ALA A 196
PRO A 199
LEU A 167
LEU A 168
 PGE  A 373 ( 4.1A)
None
None
None
 0.97A 5dzkd-3eqxA:
undetectable
5dzkr-3eqxA:
undetectable		 5dzkd-3eqxA:
18.85
5dzkr-3eqxA:
0.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 300
ALA A 299
HIS A 265
LEU A 183
 None
 1.06A 5dzkd-3fk5A:
undetectable
5dzkr-3fk5A:
undetectable		 5dzkd-3fk5A:
21.83
5dzkr-3fk5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		4 PHE A 171
PRO A 182
LEU A 175
LEU A 174
 None
EDO  A 259 (-3.5A)
None
EDO  A 259 ( 4.1A)
 0.91A 5dzkd-3ggdA:
undetectable
5dzkr-3ggdA:
undetectable		 5dzkd-3ggdA:
20.91
5dzkr-3ggdA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		4 PHE A 268
SER A 184
LEU A  90
LEU A  91
 None
 1.07A 5dzkd-3h9pA:
undetectable
5dzkr-3h9pA:
undetectable		 5dzkd-3h9pA:
23.62
5dzkr-3h9pA:
1.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 PHE A  48
SER A 152
ALA A 153
HIS A 348
 None
 1.21A 5dzkd-3i1iA:
undetectable
5dzkr-3i1iA:
undetectable		 5dzkd-3i1iA:
20.63
5dzkr-3i1iA:
0.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrp FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 SER A 224
ALA A 223
HIS A 203
LEU A 247
 None
 1.20A 5dzkd-3jrpA:
undetectable
5dzkr-3jrpA:
undetectable		 5dzkd-3jrpA:
20.89
5dzkr-3jrpA:
1.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js9 NUCLEOSIDE
DIPHOSPHATE KINASE
FAMILY PROTEIN

(Babesia bovis) 		PF00334
(NDK) 		4 SER A 117
ALA A 123
HIS A 115
LEU A 129
 None
None
SO4  A 152 (-4.0A)
None
 1.19A 5dzkd-3js9A:
undetectable
5dzkr-3js9A:
undetectable		 5dzkd-3js9A:
19.81
5dzkr-3js9A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 PHE A  31
SER A 455
HIS A 451
LEU A 493
 None
 1.15A 5dzkd-3kehA:
undetectable
5dzkr-3kehA:
undetectable		 5dzkd-3kehA:
18.43
5dzkr-3kehA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na8 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00701
(DHDPS) 		4 SER A 228
ALA A 229
LEU A 264
LEU A 268
 None
 0.91A 5dzkd-3na8A:
3.0
5dzkr-3na8A:
undetectable		 5dzkd-3na8A:
22.87
5dzkr-3na8A:
1.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		4 SER A 188
ALA A 189
PRO A 243
LEU A 244
 None
 1.06A 5dzkd-3nzpA:
undetectable
5dzkr-3nzpA:
undetectable		 5dzkd-3nzpA:
15.69
5dzkr-3nzpA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		4 PHE A 248
SER A 144
ALA A 143
HIS A 101
 None
NAD  A1385 ( 4.9A)
None
None
 1.20A 5dzkd-3ox4A:
undetectable
5dzkr-3ox4A:
undetectable		 5dzkd-3ox4A:
21.79
5dzkr-3ox4A:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rms UNCHARACTERIZED
PROTEIN

(Saccharomonospora
viridis) 		PF16827
(zf-HC3) 		4 ALA A  78
PRO A  57
LEU A  91
LEU A  87
 None
 0.70A 5dzkd-3rmsA:
undetectable
5dzkr-3rmsA:
undetectable		 5dzkd-3rmsA:
18.60
5dzkr-3rmsA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF00215
(OMPdecase) 		4 SER A  88
ALA A  87
HIS A  62
LEU A 116
 None
None
None
IOD  A 285 ( 4.8A)
 1.09A 5dzkd-3ru6A:
3.0
5dzkr-3ru6A:
undetectable		 5dzkd-3ru6A:
20.75
5dzkr-3ru6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 SER A 132
ALA A 133
LEU A 156
LEU A 160
 None
 1.04A 5dzkd-3smtA:
undetectable
5dzkr-3smtA:
undetectable		 5dzkd-3smtA:
20.16
5dzkr-3smtA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqq METHIONYL-TRNA
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 SER A  24
HIS A  26
LEU A 179
LEU A 178
 K  A 315 (-4.5A)
None
None
None
 1.20A 5dzkd-3tqqA:
undetectable
5dzkr-3tqqA:
undetectable		 5dzkd-3tqqA:
23.20
5dzkr-3tqqA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 ALA A 289
PRO A 370
LEU A 372
LEU A 359
 None
 1.11A 5dzkd-3v4cA:
3.1
5dzkr-3v4cA:
undetectable		 5dzkd-3v4cA:
19.92
5dzkr-3v4cA:
0.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 SER A 428
ALA A 427
HIS A 388
LEU A 457
 None
 1.19A 5dzkd-3v5rA:
undetectable
5dzkr-3v5rA:
undetectable		 5dzkd-3v5rA:
18.77
5dzkr-3v5rA:
0.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL

(Bos taurus) 		PF01597
(GCV_H) 		4 PHE A  52
SER A  38
ALA A  54
PRO A  40
 None
 0.94A 5dzkd-3wdnA:
undetectable
5dzkr-3wdnA:
undetectable		 5dzkd-3wdnA:
21.40
5dzkr-3wdnA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		4 SER A  65
ALA A  66
PRO A  60
LEU A 197
 None
 1.15A 5dzkd-3zrpA:
undetectable
5dzkr-3zrpA:
undetectable		 5dzkd-3zrpA:
20.82
5dzkr-3zrpA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Mycobacterium
tuberculosis) 		PF01116
(F_bP_aldolase) 		4 SER A  46
ALA A  44
PRO A  24
LEU A 335
 None
 1.15A 5dzkd-4a22A:
4.1
5dzkr-4a22A:
undetectable		 5dzkd-4a22A:
22.73
5dzkr-4a22A:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC

(Leishmania
major) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ALA A 124
PRO A 141
LEU A 133
LEU A 132
 None
 1.00A 5dzkd-4a26A:
undetectable
5dzkr-4a26A:
undetectable		 5dzkd-4a26A:
22.56
5dzkr-4a26A:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad8 DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 SER A 150
ALA A 151
LEU A 450
LEU A 441
 None
 1.10A 5dzkd-4ad8A:
undetectable
5dzkr-4ad8A:
undetectable		 5dzkd-4ad8A:
18.58
5dzkr-4ad8A:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		4 PHE A 302
SER A 308
ALA A 307
LEU A 304
 None
 0.83A 5dzkd-4bqiA:
undetectable
5dzkr-4bqiA:
undetectable		 5dzkd-4bqiA:
14.15
5dzkr-4bqiA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwi PHYTOCHROME-LIKE
PROTEIN CPH2

(Synechocystis
sp.) 		PF00360
(PHY)
PF01590
(GAF) 		4 SER A 411
ALA A 410
PRO A 312
LEU A 342
 None
 1.06A 5dzkd-4bwiA:
undetectable
5dzkr-4bwiA:
undetectable		 5dzkd-4bwiA:
21.83
5dzkr-4bwiA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ALA A 564
PRO A 584
LEU A 559
LEU A 556
 None
 1.09A 5dzkd-4bziA:
undetectable
5dzkr-4bziA:
undetectable		 5dzkd-4bziA:
14.32
5dzkr-4bziA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 SER A 754
ALA A 757
HIS A 782
LEU A 955
 None
 0.97A 5dzkd-4cakA:
undetectable
5dzkr-4cakA:
undetectable		 5dzkd-4cakA:
12.32
5dzkr-4cakA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		4 SER A 213
ALA A 212
PRO A 217
LEU A 210
 None
 1.08A 5dzkd-4euoA:
undetectable
5dzkr-4euoA:
undetectable		 5dzkd-4euoA:
25.31
5dzkr-4euoA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 311
ALA A 310
HIS A 275
LEU A 168
 None
 1.04A 5dzkd-4ewpA:
undetectable
5dzkr-4ewpA:
undetectable		 5dzkd-4ewpA:
21.31
5dzkr-4ewpA:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE

(Mycobacterium
sp. JLS) 		PF04471
(Mrr_cat) 		4 PHE A 157
ALA A 182
HIS A 142
PRO A 155
 None
 1.00A 5dzkd-4f0qA:
undetectable
5dzkr-4f0qA:
undetectable		 5dzkd-4f0qA:
18.64
5dzkr-4f0qA:
0.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE
PROTEIN DBF4 HOMOLOG
A

(Homo sapiens;
Homo sapiens) 		PF00069
(Pkinase)
PF07535
(zf-DBF) 		4 ALA B 319
HIS A 129
LEU B 310
LEU B 311
 None
 0.89A 5dzkd-4f99B:
undetectable
5dzkr-4f99B:
undetectable		 5dzkd-4f99B:
19.16
5dzkr-4f99B:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1) 		PF00661
(Matrix) 		4 ALA A 193
HIS A 238
LEU A 241
LEU A 290
 None
 0.95A 5dzkd-4g1gA:
undetectable
5dzkr-4g1gA:
undetectable		 5dzkd-4g1gA:
20.55
5dzkr-4g1gA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40) 		4 PHE B 281
SER B 263
ALA B 262
HIS B 244
 None
 1.03A 5dzkd-4g56B:
undetectable
5dzkr-4g56B:
undetectable		 5dzkd-4g56B:
21.88
5dzkr-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbm CURM
SULFOTRANSFERASE

(Moorea
producens) 		PF13469
(Sulfotransfer_3) 		4 SER A  57
ALA A  50
PRO A  59
MET A 253
 None
 1.13A 5dzkd-4gbmA:
undetectable
5dzkr-4gbmA:
undetectable		 5dzkd-4gbmA:
20.99
5dzkr-4gbmA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hht RIBONUCLEASE HII

(Thermotoga
maritima) 		PF01351
(RNase_HII) 		4 SER A  21
ALA A  20
PRO A  28
LEU A 144
 C  D   6 ( 4.7A)
C  D   6 ( 4.0A)
None
None
 0.79A 5dzkd-4hhtA:
undetectable
5dzkr-4hhtA:
undetectable		 5dzkd-4hhtA:
27.05
5dzkr-4hhtA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 SER A 101
ALA A 122
PRO A  49
LEU A  44
 None
 0.99A 5dzkd-4mrqA:
undetectable
5dzkr-4mrqA:
undetectable		 5dzkd-4mrqA:
19.43
5dzkr-4mrqA:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 SER A 343
HIS A 291
LEU A 376
LEU A 380
 None
 0.94A 5dzkd-4mx2A:
undetectable
5dzkr-4mx2A:
undetectable		 5dzkd-4mx2A:
19.05
5dzkr-4mx2A:
1.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		4 PRO A  48
MET A 179
LEU A  68
LEU A  67
 None
 1.15A 5dzkd-4mydA:
undetectable
5dzkr-4mydA:
undetectable		 5dzkd-4mydA:
21.32
5dzkr-4mydA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 PHE A 586
ALA A 590
LEU A 588
LEU A 585
 None
 1.06A 5dzkd-4nmeA:
2.7
5dzkr-4nmeA:
undetectable		 5dzkd-4nmeA:
13.76
5dzkr-4nmeA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		4 PHE A 173
SER A 120
ALA A 123
PRO A 155
 None
 0.96A 5dzkd-4q22A:
undetectable
5dzkr-4q22A:
undetectable		 5dzkd-4q22A:
20.51
5dzkr-4q22A:
2.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2

(Mycobacterium
tuberculosis) 		PF00574
(CLP_protease) 		6 PHE A  83
SER A 110
ALA A 111
HIS A 135
PRO A 137
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 (-3.8A)
ZIL  A 301 ( 2.9A)
 0.47A 5dzkd-4u0gA:
27.4
5dzkr-4u0gA:
undetectable		 5dzkd-4u0gA:
100.00
5dzkr-4u0gA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 SER A 161
ALA A 162
HIS A 292
LEU A 218
 None
 1.17A 5dzkd-4wy5A:
undetectable
5dzkr-4wy5A:
undetectable		 5dzkd-4wy5A:
24.16
5dzkr-4wy5A:
0.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3k SEPIAPTERIN
REDUCTASE

(Homo sapiens) 		PF00106
(adh_short) 		4 SER A  26
ALA A  25
LEU A  23
LEU A  20
 None
 1.16A 5dzkd-4z3kA:
undetectable
5dzkr-4z3kA:
undetectable		 5dzkd-4z3kA:
22.89
5dzkr-4z3kA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 SER A1005
PRO A1248
LEU A1001
LEU A 998
 None
 0.87A 5dzkd-5amqA:
undetectable
5dzkr-5amqA:
undetectable		 5dzkd-5amqA:
6.74
5dzkr-5amqA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Corynebacterium
glutamicum) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M) 		4 PHE A 170
SER A  75
ALA A 154
LEU A 152
 None
 1.19A 5dzkd-5e3qA:
undetectable
5dzkr-5e3qA:
undetectable		 5dzkd-5e3qA:
23.26
5dzkr-5e3qA:
0.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exc GREEN FLUORESCENT
PROTEIN
GREEN FLUORESCENT
PROTEIN

(Dendronephthya
sp. SSAL-2002;
Dendronephthya
sp. SSAL-2002) 		PF01353
(GFP)
PF01353
(GFP) 		4 SER A  53
PRO I 130
LEU I 161
LEU I 163
 None
 1.18A 5dzkd-5excA:
undetectable
5dzkr-5excA:
undetectable		 5dzkd-5excA:
14.22
5dzkr-5excA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 PHE B1197
SER B1144
ALA B1147
PRO B1179
 None
FMT  B4007 (-4.8A)
None
None
 0.95A 5dzkd-5gztB:
1.6
5dzkr-5gztB:
undetectable		 5dzkd-5gztB:
11.94
5dzkr-5gztB:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY

(Thermomonospora
curvata) 		PF04261
(Dyp_perox) 		4 PHE A 348
PRO A 329
LEU A 347
LEU A 346
 HEM  A 501 (-3.9A)
None
None
HEM  A 501 ( 4.3A)
 0.97A 5dzkd-5jxuA:
undetectable
5dzkr-5jxuA:
undetectable		 5dzkd-5jxuA:
20.68
5dzkr-5jxuA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		4 PHE A  89
SER A 132
ALA A 125
LEU A 366
 None
 1.08A 5dzkd-5l2rA:
undetectable
5dzkr-5l2rA:
undetectable		 5dzkd-5l2rA:
15.89
5dzkr-5l2rA:
1.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31

(Saccharomyces
cerevisiae) 		PF01125
(G10) 		4 ALA L  87
HIS L  56
LEU L  91
LEU L  90
 None
None
None
C  U 122 ( 4.5A)
 1.17A 5dzkd-5lj3L:
undetectable
5dzkr-5lj3L:
undetectable		 5dzkd-5lj3L:
20.18
5dzkr-5lj3L:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN7

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF10602
(RPN7) 		4 SER R 254
ALA R 253
LEU R 276
LEU R 279
 None
 0.97A 5dzkd-5mpdR:
2.3
5dzkr-5mpdR:
undetectable		 5dzkd-5mpdR:
21.19
5dzkr-5mpdR:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 4 SER A 146
ALA A 208
HIS A 147
LEU A 231
 None
 1.20A 5dzkd-5uqrA:
undetectable
5dzkr-5uqrA:
undetectable		 5dzkd-5uqrA:
undetectable
5dzkr-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF13401
(AAA_22)
PF14630
(ORC5_C) 		4 PHE E 390
SER E 335
ALA E 334
LEU E 387
 None
 0.94A 5dzkd-5v8fE:
undetectable
5dzkr-5v8fE:
undetectable		 5dzkd-5v8fE:
18.94
5dzkr-5v8fE:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 SER A 341
PRO A 336
LEU A 309
LEU A 305
 None
 1.14A 5dzkd-5wy4A:
undetectable
5dzkr-5wy4A:
undetectable		 5dzkd-5wy4A:
undetectable
5dzkr-5wy4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION

(Mycolicibacterium
smegmatis) 		PF00383
(dCMP_cyt_deam_1) 		4 PHE A  29
ALA A  21
PRO A  57
LEU A  17
 CAC  A 201 (-3.8A)
None
CAC  A 201 (-4.5A)
None
 1.19A 5dzkd-5xkoA:
undetectable
5dzkr-5xkoA:
undetectable		 5dzkd-5xkoA:
26.18
5dzkr-5xkoA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4m MONOTREME LACTATION
PROTEIN

(Ornithorhynchus
anatinus) 		no annotation 4 ALA A  20
PRO A  31
LEU A  33
LEU A  62
 None
 1.01A 5dzkd-6b4mA:
undetectable
5dzkr-6b4mA:
undetectable		 5dzkd-6b4mA:
undetectable
5dzkr-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON

(Streptomyces
fradiae) 		no annotation 4 PHE A 154
ALA A 127
LEU A 160
LEU A 159
 None
 1.05A 5dzkd-6cblA:
undetectable
5dzkr-6cblA:
undetectable		 5dzkd-6cblA:
undetectable
5dzkr-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2d FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIP
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIR

(Salmonella
enterica;
Salmonella
enterica) 		no annotation
no annotation 		4 SER F  34
HIS F 143
MET F 134
LEU A 179
 None
 1.15A 5dzkd-6f2dF:
undetectable
5dzkr-6f2dF:
undetectable		 5dzkd-6f2dF:
undetectable
5dzkr-6f2dF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 4 ALA A 216
PRO A 196
LEU A 194
LEU A 193
 None
 1.13A 5dzkd-6f8yA:
undetectable
5dzkr-6f8yA:
undetectable		 5dzkd-6f8yA:
undetectable
5dzkr-6f8yA:
undetectable