SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_Q_BEZQ801_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5w MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.26A 5dzkc-1e5wA:
undetectable
5dzkq-1e5wA:
undetectable		 5dzkc-1e5wA:
21.01
5dzkq-1e5wA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eco ERYTHROCRUORIN
(CARBONMONOXY)

(Chironomus
thummi) 		PF00042
(Globin) 		4 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.95A 5dzkc-1ecoA:
undetectable
5dzkq-1ecoA:
undetectable		 5dzkc-1ecoA:
22.12
5dzkq-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef1 MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.26A 5dzkc-1ef1A:
0.0
5dzkq-1ef1A:
undetectable		 5dzkc-1ef1A:
20.81
5dzkq-1ef1A:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flk TNF RECEPTOR
ASSOCIATED FACTOR 3

(Homo sapiens) 		no annotation 4 SER A 378
ALA A 392
MET A 414
LEU A 354
 None
 1.08A 5dzkc-1flkA:
undetectable
5dzkq-1flkA:
undetectable		 5dzkc-1flkA:
21.94
5dzkq-1flkA:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gc7 RADIXIN

(Mus musculus) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.22A 5dzkc-1gc7A:
0.0
5dzkq-1gc7A:
undetectable		 5dzkc-1gc7A:
19.68
5dzkq-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 SER A  30
ALA A  29
HIS A  31
LEU A 219
 None
 1.39A 5dzkc-1gtkA:
undetectable
5dzkq-1gtkA:
undetectable		 5dzkc-1gtkA:
24.61
5dzkq-1gtkA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4r MERLIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 SER A 143
ALA A 142
HIS A 195
LEU A 140
 None
None
SO4  A1315 (-3.9A)
None
 1.24A 5dzkc-1h4rA:
undetectable
5dzkq-1h4rA:
undetectable		 5dzkc-1h4rA:
20.67
5dzkq-1h4rA:
0.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6y PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Arabidopsis
thaliana) 		PF00639
(Rotamase) 		4 SER A  72
ALA A  73
HIS A  12
LEU A  14
 None
 1.03A 5dzkc-1j6yA:
0.0
5dzkq-1j6yA:
undetectable		 5dzkc-1j6yA:
23.15
5dzkq-1j6yA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmk SURFACTIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		4 SER C  80
ALA C  81
HIS C 207
LEU C 129
 None
 1.29A 5dzkc-1jmkC:
0.6
5dzkq-1jmkC:
undetectable		 5dzkc-1jmkC:
22.92
5dzkq-1jmkC:
1.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzn GALACTOSE-SPECIFIC
LECTIN

(Crotalus atrox) 		PF00059
(Lectin_C) 		4 SER A  42
ALA A  41
HIS A  44
LEU A  13
 NA  A1139 (-2.9A)
None
None
None
 1.20A 5dzkc-1jznA:
undetectable
5dzkq-1jznA:
undetectable		 5dzkc-1jznA:
18.02
5dzkq-1jznA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leo NUCLEOSIDE
DIPHOSPHATE KINASE

(Dictyostelium
discoideum) 		PF00334
(NDK) 		4 SER A 124
ALA A 130
HIS A 122
LEU A  13
 None
 1.43A 5dzkc-1leoA:
undetectable
5dzkq-1leoA:
undetectable		 5dzkc-1leoA:
18.89
5dzkq-1leoA:
1.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 SER A 222
ALA A 190
HIS A 220
LEU A 184
 None
None
MGD  A1804 (-4.4A)
None
 1.42A 5dzkc-1ogyA:
undetectable
5dzkq-1ogyA:
undetectable		 5dzkc-1ogyA:
14.45
5dzkq-1ogyA:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgo ANAEROBIC COBALAMIN
BIOSYNTHETIC COBALT
CHELATASE

(Salmonella
enterica) 		PF06180
(CbiK) 		4 SER A  32
ALA A  31
HIS A 253
LEU A   5
 None
 1.29A 5dzkc-1qgoA:
undetectable
5dzkq-1qgoA:
undetectable		 5dzkc-1qgoA:
21.11
5dzkq-1qgoA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgo ANAEROBIC COBALAMIN
BIOSYNTHETIC COBALT
CHELATASE

(Salmonella
enterica) 		PF06180
(CbiK) 		4 SER A  32
ALA A  31
HIS A 253
LEU A  29
 None
 1.28A 5dzkc-1qgoA:
undetectable
5dzkq-1qgoA:
undetectable		 5dzkc-1qgoA:
21.11
5dzkq-1qgoA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgy BETA-LACTAMASE

(Citrobacter
freundii) 		PF00144
(Beta-lactamase) 		4 SER A 257
ALA A 307
MET A 273
LEU A 254
 None
 1.43A 5dzkc-1rgyA:
undetectable
5dzkq-1rgyA:
undetectable		 5dzkc-1rgyA:
19.45
5dzkq-1rgyA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3i PROBABLE CYSTEINE
DESULFURASE

(Synechocystis
sp.) 		PF00266
(Aminotran_5) 		4 SER A 209
ALA A 210
HIS A 177
LEU A 225
 None
 1.35A 5dzkc-1t3iA:
undetectable
5dzkq-1t3iA:
undetectable		 5dzkc-1t3iA:
18.37
5dzkq-1t3iA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 SER A 268
ALA A 266
HIS A 536
MET A 570
 None
 1.06A 5dzkc-1we5A:
undetectable
5dzkq-1we5A:
undetectable		 5dzkc-1we5A:
13.64
5dzkq-1we5A:
0.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlf PEROXISOME
BIOGENESIS FACTOR 1

(Mus musculus) 		PF09262
(PEX-1N)
PF09263
(PEX-2N) 		4 SER A  51
ALA A  50
HIS A  53
LEU A  86
 None
 1.41A 5dzkc-1wlfA:
undetectable
5dzkq-1wlfA:
undetectable		 5dzkc-1wlfA:
22.47
5dzkq-1wlfA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3

(Homo sapiens) 		PF00334
(NDK) 		4 SER A 137
ALA A 143
HIS A 135
LEU A  26
 None
 1.40A 5dzkc-1zs6A:
undetectable
5dzkq-1zs6A:
undetectable		 5dzkc-1zs6A:
21.68
5dzkq-1zs6A:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		4 SER A  64
ALA A  67
HIS A 307
LEU A 294
 None
 1.38A 5dzkc-2drwA:
undetectable
5dzkq-2drwA:
undetectable		 5dzkc-2drwA:
20.65
5dzkq-2drwA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00782
(DSPc) 		4 SER A 190
ALA A 265
HIS A 193
MET A 299
 None
SO4  A 501 (-3.4A)
None
None
 1.41A 5dzkc-2g6zA:
undetectable
5dzkq-2g6zA:
undetectable		 5dzkc-2g6zA:
23.31
5dzkq-2g6zA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		4 SER A 329
ALA A 332
HIS A 327
MET A   9
 None
 1.20A 5dzkc-2greA:
undetectable
5dzkq-2greA:
undetectable		 5dzkc-2greA:
20.80
5dzkq-2greA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.21A 5dzkc-2i1jA:
undetectable
5dzkq-2i1jA:
undetectable		 5dzkc-2i1jA:
16.75
5dzkq-2i1jA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT
TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri;
Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS)
PF02332
(Phenol_Hydrox) 		4 SER A 108
ALA A 107
HIS B 143
MET A 181
 None
P6G  A 503 ( 3.8A)
None
None
 1.45A 5dzkc-2incA:
undetectable
5dzkq-2incA:
undetectable		 5dzkc-2incA:
19.91
5dzkq-2incA:
0.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8y PROTEIN RCSF

(Escherichia
coli) 		PF16358
(RcsF) 		4 SER A 127
ALA A 128
HIS A 107
MET A  92
 None
 1.26A 5dzkc-2l8yA:
undetectable
5dzkq-2l8yA:
undetectable		 5dzkc-2l8yA:
20.10
5dzkq-2l8yA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 327
ALA A 326
HIS A 340
MET A 358
 None
 1.40A 5dzkc-2nqlA:
1.4
5dzkq-2nqlA:
undetectable		 5dzkc-2nqlA:
19.95
5dzkq-2nqlA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 SER A 213
ALA A 181
HIS A 211
LEU A 175
 None
None
MGD  A4001 (-4.2A)
None
 1.40A 5dzkc-2nyaA:
undetectable
5dzkq-2nyaA:
undetectable		 5dzkc-2nyaA:
14.95
5dzkq-2nyaA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 328
ALA A 327
HIS A 341
MET A 359
 None
 1.45A 5dzkc-2ppgA:
1.6
5dzkq-2ppgA:
undetectable		 5dzkc-2ppgA:
19.85
5dzkq-2ppgA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vu5 NUCLEOSIDE
DIPHOSPHATE KINASE

(Bacillus
anthracis) 		PF00334
(NDK) 		4 SER A 117
ALA A 123
HIS A 115
LEU A   6
 None
 1.43A 5dzkc-2vu5A:
undetectable
5dzkq-2vu5A:
undetectable		 5dzkc-2vu5A:
20.39
5dzkq-2vu5A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		4 SER A  80
ALA A  79
MET A  65
LEU A  48
 None
 1.28A 5dzkc-2w6rA:
undetectable
5dzkq-2w6rA:
undetectable		 5dzkc-2w6rA:
20.79
5dzkq-2w6rA:
1.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 SER A 495
ALA A 498
HIS A 650
LEU A 405
 None
 1.46A 5dzkc-2wskA:
1.2
5dzkq-2wskA:
undetectable		 5dzkc-2wskA:
16.17
5dzkq-2wskA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y1b PUTATIVE OUTER
MEMBRANE PROTEIN,
SIGNAL

(Escherichia
coli) 		PF16358
(RcsF) 		4 SER A 127
ALA A 128
HIS A 107
MET A  92
 None
None
I3C  A1133 (-3.6A)
None
 1.02A 5dzkc-2y1bA:
undetectable
5dzkq-2y1bA:
undetectable		 5dzkc-2y1bA:
20.72
5dzkq-2y1bA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		4 SER A 590
ALA A 589
HIS A 707
LEU A 704
 None
 1.48A 5dzkc-2yfsA:
undetectable
5dzkq-2yfsA:
undetectable		 5dzkc-2yfsA:
17.51
5dzkq-2yfsA:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbv UNCHARACTERIZED
CONSERVED PROTEIN

(Thermotoga
maritima) 		PF01887
(SAM_adeno_trans) 		4 SER A  47
ALA A  46
HIS A  48
LEU A 158
 None
 1.41A 5dzkc-2zbvA:
undetectable
5dzkq-2zbvA:
undetectable		 5dzkc-2zbvA:
22.06
5dzkq-2zbvA:
1.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		4 SER A  95
ALA A  94
HIS A 251
LEU A  92
 None
 1.12A 5dzkc-2zukA:
undetectable
5dzkq-2zukA:
undetectable		 5dzkc-2zukA:
20.45
5dzkq-2zukA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE

(Populus
tomentosa) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 SER A  95
ALA A  94
HIS A  25
LEU A  92
 None
 1.45A 5dzkc-3a9vA:
undetectable
5dzkq-3a9vA:
undetectable		 5dzkc-3a9vA:
18.60
5dzkq-3a9vA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 SER A 180
ALA A 248
HIS A 184
LEU A 246
 None
 1.44A 5dzkc-3breA:
undetectable
5dzkq-3breA:
undetectable		 5dzkc-3breA:
19.83
5dzkq-3breA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		4 SER A 201
ALA A 204
MET A 282
LEU A 270
 None
 1.11A 5dzkc-3hf1A:
undetectable
5dzkq-3hf1A:
undetectable		 5dzkc-3hf1A:
20.51
5dzkq-3hf1A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 SER A 456
ALA A 457
HIS A 156
LEU A 152
 None
None
None
SIN  A 504 (-4.8A)
 1.11A 5dzkc-3ju8A:
undetectable
5dzkq-3ju8A:
undetectable		 5dzkc-3ju8A:
17.72
5dzkq-3ju8A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 SER A 289
ALA A 288
HIS A 265
LEU A 168
 None
 1.49A 5dzkc-3jv7A:
undetectable
5dzkq-3jv7A:
undetectable		 5dzkc-3jv7A:
22.03
5dzkq-3jv7A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kp8 VKORC1/THIOREDOXIN
DOMAIN PROTEIN

(Synechococcus
sp.
JA-2-3B'a(2-13)) 		no annotation 4 SER A 275
ALA A 274
HIS A 195
LEU A 192
 None
 1.48A 5dzkc-3kp8A:
undetectable
5dzkq-3kp8A:
undetectable		 5dzkc-3kp8A:
17.54
5dzkq-3kp8A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 SER A 380
ALA A 379
HIS A 338
LEU A 377
 None
 1.32A 5dzkc-3na0A:
undetectable
5dzkq-3na0A:
undetectable		 5dzkc-3na0A:
19.16
5dzkq-3na0A:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocr CLASS II
ALDOLASE/ADDUCIN
DOMAIN PROTEIN

(Pseudomonas
savastanoi) 		PF00596
(Aldolase_II) 		4 SER A  57
ALA A  58
HIS A 110
LEU A 124
 None
 1.16A 5dzkc-3ocrA:
undetectable
5dzkq-3ocrA:
undetectable		 5dzkc-3ocrA:
22.76
5dzkq-3ocrA:
1.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q7h ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Coxiella
burnetii) 		PF00574
(CLP_protease) 		4 SER A  99
ALA A 102
HIS A 124
LEU A 151
 None
 1.45A 5dzkc-3q7hA:
26.9
5dzkq-3q7hA:
undetectable		 5dzkc-3q7hA:
47.12
5dzkq-3q7hA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8y NUCLEOSIDE
DIPHOSPHATE KINASE

(Staphylococcus
aureus) 		PF00334
(NDK) 		4 SER A 117
ALA A 123
HIS A 115
LEU A   6
 None
None
VO4  A 159 (-2.7A)
None
 1.43A 5dzkc-3q8yA:
undetectable
5dzkq-3q8yA:
undetectable		 5dzkc-3q8yA:
21.17
5dzkq-3q8yA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r45 HISTONE H3-LIKE
CENTROMERIC PROTEIN
A
HOLLIDAY JUNCTION
RECOGNITION PROTEIN

(Homo sapiens;
Homo sapiens) 		PF00125
(Histone)
PF10384
(Scm3) 		4 SER C  25
ALA C  24
HIS A 104
LEU C  22
 None
 1.21A 5dzkc-3r45C:
undetectable
5dzkq-3r45C:
undetectable		 5dzkc-3r45C:
14.58
5dzkq-3r45C:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6n DESMOPLAKIN

(Homo sapiens) 		no annotation 4 SER A 262
ALA A 261
HIS A 225
LEU A 259
 None
 1.43A 5dzkc-3r6nA:
undetectable
5dzkq-3r6nA:
undetectable		 5dzkc-3r6nA:
18.48
5dzkq-3r6nA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Coxiella
burnetii) 		PF01590
(GAF) 		4 SER A 134
ALA A  90
HIS A 110
LEU A  94
 None
 1.24A 5dzkc-3trcA:
undetectable
5dzkq-3trcA:
undetectable		 5dzkc-3trcA:
23.89
5dzkq-3trcA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad8 DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 SER A 150
ALA A 151
HIS A 146
LEU A 450
 None
 1.39A 5dzkc-4ad8A:
undetectable
5dzkq-4ad8A:
undetectable		 5dzkc-4ad8A:
18.58
5dzkq-4ad8A:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8w GDP-L-FUCOSE
SYNTHASE

(Homo sapiens) 		PF01370
(Epimerase) 		4 SER A 111
ALA A 167
HIS A  68
LEU A  98
 None
 1.47A 5dzkc-4b8wA:
0.8
5dzkq-4b8wA:
undetectable		 5dzkc-4b8wA:
20.18
5dzkq-4b8wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5

(Nostoc sp. PCC
7120) 		no annotation 4 SER A  43
ALA A  23
HIS A 231
LEU A  29
 None
 1.48A 5dzkc-4fekA:
undetectable
5dzkq-4fekA:
undetectable		 5dzkc-4fekA:
23.19
5dzkq-4fekA:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40) 		4 SER B 263
ALA B 262
HIS B 244
LEU B 273
 None
 1.46A 5dzkc-4g56B:
undetectable
5dzkq-4g56B:
undetectable		 5dzkc-4g56B:
21.88
5dzkq-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h17 HYDROLASE,
ISOCHORISMATASE
FAMILY

(Pseudomonas
putida) 		PF00857
(Isochorismatase) 		4 SER A 157
ALA A 156
HIS A 175
LEU A 152
 None
None
EDO  A 206 ( 4.1A)
None
 1.16A 5dzkc-4h17A:
undetectable
5dzkq-4h17A:
undetectable		 5dzkc-4h17A:
24.27
5dzkq-4h17A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2

(Homo sapiens) 		PF00415
(RCC1) 		4 SER A 563
ALA A 564
HIS A 506
LEU A 508
 None
 1.49A 5dzkc-4l1mA:
undetectable
5dzkq-4l1mA:
undetectable		 5dzkc-4l1mA:
19.74
5dzkq-4l1mA:
0.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1

(Homo sapiens) 		PF00400
(WD40) 		4 SER A 417
ALA A 416
HIS A 390
LEU A 373
 None
 1.46A 5dzkc-4lg9A:
undetectable
5dzkq-4lg9A:
undetectable		 5dzkc-4lg9A:
20.10
5dzkq-4lg9A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 SER A 488
ALA A 487
HIS A 489
LEU A 485
 None
 0.96A 5dzkc-4qs9A:
undetectable
5dzkq-4qs9A:
undetectable		 5dzkc-4qs9A:
17.92
5dzkq-4qs9A:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		4 SER A 125
ALA A 151
HIS A 244
LEU A  51
 None
 1.40A 5dzkc-4rgyA:
undetectable
5dzkq-4rgyA:
undetectable		 5dzkc-4rgyA:
20.80
5dzkq-4rgyA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 SER A2274
ALA A2273
MET A1607
LEU A2270
 None
 1.04A 5dzkc-4rlvA:
undetectable
5dzkq-4rlvA:
undetectable		 5dzkc-4rlvA:
13.96
5dzkq-4rlvA:
1.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2

(Mycobacterium
tuberculosis) 		PF00574
(CLP_protease) 		4 SER A 110
ALA A 111
HIS A 135
MET A 164
 ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 ( 2.9A)
 0.42A 5dzkc-4u0gA:
27.3
5dzkq-4u0gA:
undetectable		 5dzkc-4u0gA:
100.00
5dzkq-4u0gA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		4 SER A 300
ALA A 309
HIS A 320
LEU A  32
 None
 1.28A 5dzkc-4u9oA:
undetectable
5dzkq-4u9oA:
undetectable		 5dzkc-4u9oA:
22.04
5dzkq-4u9oA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvj COHESIN SUBUNIT SCC3

(Saccharomyces
cerevisiae) 		no annotation 4 SER A 692
ALA A 691
MET A 746
LEU A 688
 None
 0.89A 5dzkc-4uvjA:
undetectable
5dzkq-4uvjA:
undetectable		 5dzkc-4uvjA:
20.15
5dzkq-4uvjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 SER A 164
ALA A 165
HIS A 291
MET A 218
 None
 1.21A 5dzkc-4wy8A:
undetectable
5dzkq-4wy8A:
undetectable		 5dzkc-4wy8A:
22.94
5dzkq-4wy8A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		4 SER A 158
ALA A 159
HIS A 155
MET A 148
 None
 1.45A 5dzkc-4wyiA:
1.9
5dzkq-4wyiA:
undetectable		 5dzkc-4wyiA:
20.99
5dzkq-4wyiA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		4 SER A 158
ALA A 161
HIS A 155
LEU A 321
 None
 1.46A 5dzkc-4wyiA:
1.9
5dzkq-4wyiA:
undetectable		 5dzkc-4wyiA:
20.99
5dzkq-4wyiA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yf1 LMO0812 PROTEIN

(Listeria
monocytogenes) 		PF13328
(HD_4) 		4 SER A  79
ALA A  78
HIS A  80
LEU A  76
 None
 1.33A 5dzkc-4yf1A:
undetectable
5dzkq-4yf1A:
undetectable		 5dzkc-4yf1A:
23.24
5dzkq-4yf1A:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		4 SER A 159
ALA A 160
HIS A 283
MET A 213
 None
 1.23A 5dzkc-4ypvA:
2.0
5dzkq-4ypvA:
undetectable		 5dzkc-4ypvA:
22.35
5dzkq-4ypvA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 SER A  76
ALA A 358
HIS A 320
LEU A 131
 None
 1.32A 5dzkc-4yzoA:
undetectable
5dzkq-4yzoA:
undetectable		 5dzkc-4yzoA:
19.79
5dzkq-4yzoA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 SER A 243
ALA A 242
HIS A  86
LEU A 114
 C  E   2 ( 2.8A)
C  E   3 ( 3.5A)
ZN  A1458 (-3.5A)
None
 1.48A 5dzkc-5a0tA:
1.3
5dzkq-5a0tA:
undetectable		 5dzkc-5a0tA:
19.00
5dzkq-5a0tA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu6 BPSB (PGAB),
POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Bordetella
bronchiseptica) 		PF01522
(Polysacc_deac_1) 		4 ALA A  57
HIS A 189
MET A  62
LEU A  55
 None
NI  A 401 ( 3.3A)
None
None
 1.43A 5dzkc-5bu6A:
undetectable
5dzkq-5bu6A:
undetectable		 5dzkc-5bu6A:
22.22
5dzkq-5bu6A:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156

(uncultured
organism) 		no annotation 4 SER A 232
ALA A 261
HIS A 231
LEU A 352
 None
 1.04A 5dzkc-5d8mA:
undetectable
5dzkq-5d8mA:
undetectable		 5dzkc-5d8mA:
22.62
5dzkq-5d8mA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 SER A 192
ALA A 193
HIS A 145
LEU A 189
 CL  A 614 (-3.2A)
None
None
None
 1.37A 5dzkc-5dqfA:
undetectable
5dzkq-5dqfA:
undetectable		 5dzkc-5dqfA:
16.98
5dzkq-5dqfA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elp NRPS/PKS PROTEIN

(Bacillus
amyloliquefaciens) 		no annotation 4 SER C 420
ALA C 316
HIS C 430
LEU C 332
 None
 1.40A 5dzkc-5elpC:
undetectable
5dzkq-5elpC:
undetectable		 5dzkc-5elpC:
15.27
5dzkq-5elpC:
1.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		4 SER A  71
ALA A  70
HIS A 147
LEU A  68
 None
 1.26A 5dzkc-5fyaA:
undetectable
5dzkq-5fyaA:
undetectable		 5dzkc-5fyaA:
23.46
5dzkq-5fyaA:
1.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		4 SER A 193
ALA A 194
HIS A 146
LEU A 190
 None
 1.40A 5dzkc-5ghkA:
undetectable
5dzkq-5ghkA:
undetectable		 5dzkc-5ghkA:
16.67
5dzkq-5ghkA:
1.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Streptococcus
porcinus) 		PF01791
(DeoC) 		4 SER A 240
ALA A 239
HIS A 241
LEU A 203
 None
 1.44A 5dzkc-5hjlA:
1.6
5dzkq-5hjlA:
undetectable		 5dzkc-5hjlA:
22.80
5dzkq-5hjlA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 228
HIS A  33
MET A   1
LEU A 226
 None
 1.37A 5dzkc-5ie2A:
undetectable
5dzkq-5ie2A:
undetectable		 5dzkc-5ie2A:
20.32
5dzkq-5ie2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 SER B 337
ALA B 334
HIS B 341
LEU B 732
 None
 1.07A 5dzkc-5iz5B:
undetectable
5dzkq-5iz5B:
undetectable		 5dzkc-5iz5B:
13.54
5dzkq-5iz5B:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7v DESIGNED PROTEIN
HR00C3

(synthetic
construct) 		no annotation 4 SER A 183
ALA A 182
MET A 129
LEU A 180
 None
 1.09A 5dzkc-5k7vA:
2.5
5dzkq-5k7vA:
undetectable		 5dzkc-5k7vA:
23.15
5dzkq-5k7vA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)

(Helicobacter
pylori) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 SER A 269
ALA A 253
HIS A 161
LEU A 299
 None
 1.29A 5dzkc-5lp4A:
undetectable
5dzkq-5lp4A:
undetectable		 5dzkc-5lp4A:
17.77
5dzkq-5lp4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III

(Rhizobium
freirei) 		PF00202
(Aminotran_3) 		4 SER A  95
ALA A  94
HIS A 251
LEU A  92
 None
 1.12A 5dzkc-5m49A:
undetectable
5dzkq-5m49A:
undetectable		 5dzkc-5m49A:
20.95
5dzkq-5m49A:
1.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mal LIPASE

(Streptomyces
rimosus) 		PF13472
(Lipase_GDSL_2) 		4 SER A  41
ALA A  40
HIS A  42
LEU A 227
 None
 1.09A 5dzkc-5malA:
undetectable
5dzkq-5malA:
undetectable		 5dzkc-5malA:
23.20
5dzkq-5malA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 SER B 619
ALA B 616
MET B 608
LEU B 676
 None
 1.42A 5dzkc-5mrwB:
1.8
5dzkq-5mrwB:
undetectable		 5dzkc-5mrwB:
16.36
5dzkq-5mrwB:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol9 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 SER A  72
ALA A  71
HIS A 137
LEU A 134
 None
 1.44A 5dzkc-5ol9A:
undetectable
5dzkq-5ol9A:
undetectable		 5dzkc-5ol9A:
16.97
5dzkq-5ol9A:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 SER p  86
ALA p  85
HIS p  66
LEU p  40
 None
 1.42A 5dzkc-5optp:
undetectable
5dzkq-5optp:
undetectable		 5dzkc-5optp:
19.51
5dzkq-5optp:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		4 SER A 458
ALA A 459
HIS A 159
LEU A 155
 8YP  A 507 (-2.3A)
8YP  A 507 (-2.8A)
8YP  A 507 (-3.1A)
8YP  A 507 (-3.8A)
 1.20A 5dzkc-5u0lA:
undetectable
5dzkq-5u0lA:
undetectable		 5dzkc-5u0lA:
17.81
5dzkq-5u0lA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Spodoptera
frugiperda;
Homo sapiens) 		no annotation 4 SER A  90
ALA A  89
HIS A 139
LEU A  87
 None
 1.18A 5dzkc-5v54A:
undetectable
5dzkq-5v54A:
undetectable		 5dzkc-5v54A:
undetectable
5dzkq-5v54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		4 SER f 409
ALA f 410
MET f 416
LEU f 372
 None
 1.24A 5dzkc-5vhif:
undetectable
5dzkq-5vhif:
undetectable		 5dzkc-5vhif:
13.63
5dzkq-5vhif:
1.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 SER H  98
ALA H 101
HIS H  34
LEU L 100
 None
 1.20A 5dzkc-6aq7H:
undetectable
5dzkq-6aq7H:
undetectable		 5dzkc-6aq7H:
undetectable
5dzkq-6aq7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgi ANOCTAMIN-1

(Mus musculus) 		no annotation 4 SER A 401
ALA A 400
HIS A 402
LEU A 630
 None
 1.43A 5dzkc-6bgiA:
undetectable
5dzkq-6bgiA:
undetectable		 5dzkc-6bgiA:
undetectable
5dzkq-6bgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2

(Danio rerio) 		no annotation 4 SER A 172
ALA A 171
HIS A 173
LEU A 169
 None
 1.48A 5dzkc-6d21A:
undetectable
5dzkq-6d21A:
undetectable		 5dzkc-6d21A:
undetectable
5dzkq-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2

(Danio rerio) 		no annotation 4 SER A 172
ALA A 171
HIS A 214
LEU A 169
 None
 1.26A 5dzkc-6d21A:
undetectable
5dzkq-6d21A:
undetectable		 5dzkc-6d21A:
undetectable
5dzkq-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 4 SER K 831
ALA K 830
HIS K 835
LEU K 532
 None
 1.31A 5dzkc-6d6qK:
undetectable
5dzkq-6d6qK:
undetectable		 5dzkc-6d6qK:
undetectable
5dzkq-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dnh PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 4 SER B 349
ALA B 336
HIS B 330
LEU B 356
 None
 1.45A 5dzkc-6dnhB:
undetectable
5dzkq-6dnhB:
undetectable		 5dzkc-6dnhB:
undetectable
5dzkq-6dnhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2d FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIP
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIR

(Salmonella
enterica;
Salmonella
enterica) 		no annotation
no annotation 		4 SER F  34
HIS F 143
MET F 134
LEU A 179
 None
 1.04A 5dzkc-6f2dF:
undetectable
5dzkq-6f2dF:
undetectable		 5dzkc-6f2dF:
undetectable
5dzkq-6f2dF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffl MALTOSE/MALTODEXTRIN
TRANSPORT PERMEASE
HOMOLOGUE

(Bdellovibrio
bacteriovorus) 		no annotation 4 SER A 331
ALA A 332
HIS A 115
LEU A 310
 None
 1.18A 5dzkc-6fflA:
undetectable
5dzkq-6fflA:
undetectable		 5dzkc-6fflA:
undetectable
5dzkq-6fflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 4 SER S  90
ALA S  89
HIS S 139
LEU S  87
 None
 1.14A 5dzkc-6g79S:
undetectable
5dzkq-6g79S:
undetectable		 5dzkc-6g79S:
undetectable
5dzkq-6g79S:
undetectable