SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_O_BEZO801_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 SER A 461
HIS A 463
PRO A 526
LEU A 523
 None
 1.29A 5dzka-1amuA:
undetectable
5dzko-1amuA:
undetectable		 5dzka-1amuA:
16.58
5dzko-1amuA:
1.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0n PROTEIN (CSDB
PROTEIN)

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 PHE A  90
HIS A  55
PRO A 279
MET A  69
 None
 1.36A 5dzka-1c0nA:
undetectable
5dzko-1c0nA:
undetectable		 5dzka-1c0nA:
19.80
5dzko-1c0nA:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 PHE A 362
SER A 351
HIS A 119
LEU A 361
 None
 1.37A 5dzka-1d0nA:
undetectable
5dzko-1d0nA:
undetectable		 5dzka-1d0nA:
15.07
5dzko-1d0nA:
1.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqp DOC1/APC10

(Saccharomyces
cerevisiae) 		PF03256
(ANAPC10) 		4 PHE A 235
HIS A 239
PRO A 183
LEU A 185
 None
 1.50A 5dzka-1gqpA:
undetectable
5dzko-1gqpA:
undetectable		 5dzka-1gqpA:
22.71
5dzko-1gqpA:
1.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 PHE A   6
HIS A 490
PRO A 531
LEU A 528
 None
 1.03A 5dzka-1lnsA:
0.8
5dzko-1lnsA:
undetectable		 5dzka-1lnsA:
15.92
5dzko-1lnsA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 PHE A 305
SER A 310
HIS A 311
LEU A 307
 None
 0.98A 5dzka-1muuA:
2.9
5dzko-1muuA:
undetectable		 5dzka-1muuA:
18.88
5dzko-1muuA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 PHE A 505
PRO A 517
MET A 565
LEU A 506
 None
 1.33A 5dzka-1nr0A:
undetectable
5dzko-1nr0A:
undetectable		 5dzka-1nr0A:
16.53
5dzko-1nr0A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8m TRIGGERING RECEPTOR
EXPRESSED ON MYELOID
CELLS 1

(Homo sapiens) 		PF07686
(V-set) 		4 PHE A  48
SER A  74
HIS A  91
LEU A  96
 None
 1.35A 5dzka-1q8mA:
undetectable
5dzko-1q8mA:
undetectable		 5dzka-1q8mA:
15.02
5dzko-1q8mA:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smo TRIGGERING RECEPTOR
EXPRESSED ON MYELOID
CELLS 1

(Homo sapiens) 		PF07686
(V-set) 		4 PHE A  48
SER A  74
HIS A  91
LEU A  96
 None
 1.37A 5dzka-1smoA:
undetectable
5dzko-1smoA:
undetectable		 5dzka-1smoA:
15.76
5dzko-1smoA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9f PROTEIN 1D10

(Caenorhabditis
elegans) 		PF02815
(MIR) 		4 PHE A 124
SER A 107
HIS A 155
LEU A 105
 None
 1.36A 5dzka-1t9fA:
undetectable
5dzko-1t9fA:
undetectable		 5dzka-1t9fA:
19.66
5dzko-1t9fA:
1.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 PHE A 424
HIS A 252
MET A 333
LEU A 420
 None
 1.06A 5dzka-1v5cA:
undetectable
5dzko-1v5cA:
undetectable		 5dzka-1v5cA:
21.26
5dzko-1v5cA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		4 PHE A 428
SER A 334
HIS A 339
PRO A 340
 None
 1.27A 5dzka-2dv6A:
undetectable
5dzko-2dv6A:
undetectable		 5dzka-2dv6A:
18.22
5dzko-2dv6A:
0.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2k METHIONINE SYNTHASE

(Homo sapiens) 		PF02965
(Met_synt_B12) 		4 PHE A1062
PRO A1175
MET A1189
LEU A1082
 None
 1.38A 5dzka-2o2kA:
undetectable
5dzko-2o2kA:
undetectable		 5dzka-2o2kA:
21.13
5dzko-2o2kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvb HALOALKANE
DEHALOGENASE 3

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 PHE A 195
PRO A 204
MET A  67
LEU A 206
 None
 1.49A 5dzka-2qvbA:
undetectable
5dzko-2qvbA:
undetectable		 5dzka-2qvbA:
22.73
5dzko-2qvbA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia) 		PF03466
(LysR_substrate) 		4 PHE A 175
HIS A 196
MET A 186
LEU A 241
 None
None
None
GOL  A1312 (-4.2A)
 1.37A 5dzka-2uyeA:
undetectable
5dzko-2uyeA:
undetectable		 5dzka-2uyeA:
22.04
5dzko-2uyeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 PHE A 612
HIS A 481
MET A 505
LEU A 561
 None
 1.44A 5dzka-2v5dA:
2.0
5dzko-2v5dA:
undetectable		 5dzka-2v5dA:
14.56
5dzko-2v5dA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 PHE A 612
SER A 605
HIS A 481
LEU A 561
 None
 1.46A 5dzka-2v5dA:
2.0
5dzko-2v5dA:
undetectable		 5dzka-2v5dA:
14.56
5dzko-2v5dA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 PHE A 403
SER A 495
HIS A 650
LEU A 405
 None
 1.21A 5dzka-2wskA:
1.6
5dzko-2wskA:
undetectable		 5dzka-2wskA:
16.17
5dzko-2wskA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtn EST1E

(Butyrivibrio
proteoclasticus) 		PF08386
(Abhydrolase_4)
PF12146
(Hydrolase_4) 		4 SER A 205
PRO A 127
MET A 112
LEU A 217
 None
 1.44A 5dzka-2wtnA:
3.1
5dzko-2wtnA:
undetectable		 5dzka-2wtnA:
21.79
5dzko-2wtnA:
1.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7r LYSR-TYPE REGULATORY
PROTEIN

(Burkholderia
sp. DNT) 		PF03466
(LysR_substrate) 		4 PHE A 175
HIS A 196
MET A 186
LEU A 241
 None
 1.41A 5dzka-2y7rA:
undetectable
5dzko-2y7rA:
undetectable		 5dzka-2y7rA:
20.00
5dzko-2y7rA:
1.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 PHE A  24
HIS A 165
PRO A 166
LEU A 159
 None
 1.28A 5dzka-2yfkA:
undetectable
5dzko-2yfkA:
undetectable		 5dzka-2yfkA:
19.62
5dzko-2yfkA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		4 PHE A 280
HIS A  96
PRO A 269
LEU A 271
 None
 1.49A 5dzka-3a9xA:
undetectable
5dzko-3a9xA:
undetectable		 5dzka-3a9xA:
20.24
5dzko-3a9xA:
0.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf5 RIBOKINASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00294
(PfkB) 		4 PHE A 205
SER A 170
HIS A 164
PRO A 189
 None
 1.22A 5dzka-3bf5A:
undetectable
5dzko-3bf5A:
undetectable		 5dzka-3bf5A:
21.59
5dzko-3bf5A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		4 PHE A 148
SER A  46
MET A 145
LEU A 149
 None
 1.14A 5dzka-3clwA:
1.4
5dzko-3clwA:
undetectable		 5dzka-3clwA:
18.55
5dzko-3clwA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A 193
PRO A 192
MET A  61
LEU A 197
 None
 1.49A 5dzka-3e7wA:
undetectable
5dzko-3e7wA:
undetectable		 5dzka-3e7wA:
18.00
5dzko-3e7wA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guw UNCHARACTERIZED
PROTEIN AF_1765

(Archaeoglobus
fulgidus) 		PF01026
(TatD_DNase) 		4 PHE A  54
SER A   9
PRO A  56
LEU A  51
 None
 1.48A 5dzka-3guwA:
3.6
5dzko-3guwA:
undetectable		 5dzka-3guwA:
22.22
5dzko-3guwA:
1.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 PHE C 292
HIS C 108
PRO C 281
LEU C 283
 None
 1.40A 5dzka-3gzdC:
undetectable
5dzko-3gzdC:
undetectable		 5dzka-3gzdC:
17.61
5dzko-3gzdC:
0.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzi TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Shewanella
loihica) 		PF00440
(TetR_N) 		4 PHE A 174
PRO A 109
MET A 102
LEU A 113
 None
UNL  A 218 ( 4.0A)
None
None
 1.36A 5dzka-3gziA:
undetectable
5dzko-3gziA:
undetectable		 5dzka-3gziA:
24.29
5dzko-3gziA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		4 PHE A 474
SER A 362
HIS A 360
LEU A 502
 None
 1.47A 5dzka-3ik2A:
2.2
5dzko-3ik2A:
undetectable		 5dzka-3ik2A:
18.15
5dzko-3ik2A:
0.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io3 DEHA2D07832P

(Debaryomyces
hansenii) 		PF02374
(ArsA_ATPase) 		4 SER A 264
HIS A 305
PRO A   7
LEU A   9
 None
 1.48A 5dzka-3io3A:
undetectable
5dzko-3io3A:
undetectable		 5dzka-3io3A:
20.64
5dzko-3io3A:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF06094
(GGACT) 		4 PHE A 117
SER A 120
HIS A  55
LEU A  93
 None
 1.39A 5dzka-3jucA:
undetectable
5dzko-3jucA:
undetectable		 5dzka-3jucA:
18.14
5dzko-3jucA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln7 GLUTATHIONE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
GSHAB

(Pasteurella
multocida) 		PF02655
(ATP-grasp_3)
PF04262
(Glu_cys_ligase) 		4 PHE A 735
SER A 672
PRO A 627
MET A 731
 None
 1.45A 5dzka-3ln7A:
undetectable
5dzko-3ln7A:
undetectable		 5dzka-3ln7A:
15.78
5dzko-3ln7A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		4 PHE A  26
SER A  31
HIS A 334
LEU A  29
 None
None
MN  A 397 (-3.4A)
None
 1.42A 5dzka-3m8yA:
undetectable
5dzko-3m8yA:
undetectable		 5dzka-3m8yA:
21.17
5dzko-3m8yA:
1.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF02815
(MIR) 		4 PHE A  73
SER A  56
HIS A 109
LEU A  54
 None
 1.40A 5dzka-3malA:
undetectable
5dzko-3malA:
undetectable		 5dzka-3malA:
19.65
5dzko-3malA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE

(Saccharomyces
cerevisiae) 		PF00282
(Pyridoxal_deC) 		4 PHE C 366
SER C 343
MET C 392
LEU C 364
 None
 1.46A 5dzka-3mc6C:
undetectable
5dzko-3mc6C:
undetectable		 5dzka-3mc6C:
19.55
5dzko-3mc6C:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ono RIBOSE/GALACTOSE
ISOMERASE

(Vibrio
parahaemolyticus) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		4 SER A  56
HIS A  84
PRO A  85
LEU A 172
 None
 1.46A 5dzka-3onoA:
undetectable
5dzko-3onoA:
undetectable		 5dzka-3onoA:
22.82
5dzko-3onoA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py6 BETA-LACTAMASE-LIKE

(Brucella
abortus) 		PF12706
(Lactamase_B_2) 		4 PHE A 220
SER A 218
HIS A 170
LEU A 211
 None
5GP  A 303 ( 4.3A)
MN  A 301 ( 3.4A)
None
 1.18A 5dzka-3py6A:
undetectable
5dzko-3py6A:
undetectable		 5dzka-3py6A:
23.96
5dzko-3py6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 PHE A  49
HIS A  98
MET A  63
LEU A  75
 None
 1.36A 5dzka-3qlvA:
undetectable
5dzko-3qlvA:
undetectable		 5dzka-3qlvA:
20.20
5dzko-3qlvA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		4 HIS A 120
PRO A 156
MET A 176
LEU A 159
 ZN  A 472 (-3.4A)
None
None
None
 1.40A 5dzka-3tp9A:
undetectable
5dzko-3tp9A:
undetectable		 5dzka-3tp9A:
17.93
5dzko-3tp9A:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1t DMMA HALOALKANE
DEHALOGENASE

(unidentified) 		PF00561
(Abhydrolase_1) 		4 PHE A 236
PRO A 244
MET A 107
LEU A 246
 None
 1.45A 5dzka-3u1tA:
undetectable
5dzko-3u1tA:
undetectable		 5dzka-3u1tA:
22.36
5dzko-3u1tA:
0.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE

(Pyrococcus
horikoshii) 		no annotation 4 PHE A  45
HIS A  95
PRO A  94
LEU A  92
 None
 1.39A 5dzka-3u4gA:
undetectable
5dzko-3u4gA:
undetectable		 5dzka-3u4gA:
21.36
5dzko-3u4gA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uuf LIP1, SECRETORY
LIPASE (FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		4 SER A 171
HIS A 281
PRO A 231
LEU A 106
 None
 1.33A 5dzka-3uufA:
2.3
5dzko-3uufA:
undetectable		 5dzka-3uufA:
22.57
5dzko-3uufA:
1.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 PHE A 488
PRO A 487
MET A 323
LEU A 437
 None
 1.47A 5dzka-3vm5A:
2.5
5dzko-3vm5A:
undetectable		 5dzka-3vm5A:
16.19
5dzko-3vm5A:
1.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aay AROB

(Rhizobium sp.
NT-26) 		PF00355
(Rieske) 		4 PHE B 108
SER B 126
PRO B 122
LEU B 110
 None
FES  B2006 (-2.9A)
None
None
 1.45A 5dzka-4aayB:
undetectable
5dzko-4aayB:
undetectable		 5dzka-4aayB:
19.82
5dzko-4aayB:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Burkholderia
ambifaria) 		PF02222
(ATP-grasp) 		4 PHE A  83
SER A  49
HIS A  58
PRO A  45
 None
 1.48A 5dzka-4e4tA:
undetectable
5dzko-4e4tA:
undetectable		 5dzka-4e4tA:
19.51
5dzko-4e4tA:
0.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f06 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 PHE A 101
SER A  80
PRO A 103
LEU A  99
 None
None
SO4  A 404 (-3.5A)
None
 1.22A 5dzka-4f06A:
undetectable
5dzko-4f06A:
undetectable		 5dzka-4f06A:
21.52
5dzko-4f06A:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0d POLY [ADP-RIBOSE]
POLYMERASE 16

(Homo sapiens) 		PF00644
(PARP) 		4 SER A 210
HIS A 196
PRO A 195
LEU A 191
 None
 1.13A 5dzka-4f0dA:
undetectable
5dzko-4f0dA:
undetectable		 5dzka-4f0dA:
19.23
5dzko-4f0dA:
0.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40) 		4 PHE B 281
SER B 263
HIS B 244
LEU B 273
 None
 1.39A 5dzka-4g56B:
undetectable
5dzko-4g56B:
undetectable		 5dzka-4g56B:
21.88
5dzko-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 101
HIS A 102
PRO A  99
LEU A  97
 None
None
TLA  A 502 (-4.3A)
None
 1.22A 5dzka-4it1A:
2.0
5dzko-4it1A:
undetectable		 5dzka-4it1A:
21.16
5dzko-4it1A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmh CLAMP SHC1_PY239/240

(synthetic
construct) 		PF00017
(SH2)
PF00041
(fn3) 		4 PHE A  81
SER A  78
HIS A  87
LEU A  54
 None
 1.38A 5dzka-4jmhA:
undetectable
5dzko-4jmhA:
undetectable		 5dzka-4jmhA:
22.54
5dzko-4jmhA:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 SER A 248
HIS A 349
PRO A 350
LEU A 250
 None
 1.32A 5dzka-4o99A:
undetectable
5dzko-4o99A:
undetectable		 5dzka-4o99A:
19.31
5dzko-4o99A:
0.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oiy PROTEIN TRANSPORT
PROTEIN SEC7

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		4 PHE A1002
SER A 958
MET A 975
LEU A 998
 None
 1.23A 5dzka-4oiyA:
undetectable
5dzko-4oiyA:
undetectable		 5dzka-4oiyA:
24.89
5dzko-4oiyA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roq MALYL-COA
LYASE/BETA-METHYLMAL
YL-COA LYASE

(Methylobacterium
extorquens) 		PF03328
(HpcH_HpaI) 		4 PHE A 250
SER A 162
PRO A 224
MET A 213
 None
 1.45A 5dzka-4roqA:
2.9
5dzko-4roqA:
undetectable		 5dzka-4roqA:
24.93
5dzko-4roqA:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2

(Mycobacterium
tuberculosis) 		PF00574
(CLP_protease) 		5 PHE A  83
SER A 110
HIS A 135
PRO A 137
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 (-3.8A)
ZIL  A 301 ( 2.9A)
 0.49A 5dzka-4u0gA:
27.3
5dzko-4u0gA:
undetectable		 5dzka-4u0gA:
100.00
5dzko-4u0gA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w79 PROTEIN N-TERMINAL
GLUTAMINE
AMIDOHYDROLASE

(Homo sapiens) 		PF09764
(Nt_Gln_amidase) 		4 PHE A  94
SER A  15
PRO A 105
LEU A  84
 None
 1.22A 5dzka-4w79A:
undetectable
5dzko-4w79A:
undetectable		 5dzka-4w79A:
19.91
5dzko-4w79A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wdr HALOALKANE
DEHALOGENASE

(Sphingobium
japonicum) 		PF00561
(Abhydrolase_1) 		4 PHE A 194
PRO A 203
MET A  66
LEU A 205
 None
 1.45A 5dzka-4wdrA:
undetectable
5dzko-4wdrA:
undetectable		 5dzka-4wdrA:
24.57
5dzko-4wdrA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 SER A 260
HIS A 223
PRO A 225
LEU A 262
 None
 1.29A 5dzka-4xhjA:
undetectable
5dzko-4xhjA:
undetectable		 5dzka-4xhjA:
14.07
5dzko-4xhjA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0f TAR DNA-BINDING
PROTEIN 43

(Homo sapiens) 		PF00076
(RRM_1) 		4 PHE A 149
SER A 104
PRO A 178
LEU A 106
 None
 1.46A 5dzka-4y0fA:
undetectable
5dzko-4y0fA:
undetectable		 5dzka-4y0fA:
17.31
5dzko-4y0fA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 PHE A 612
HIS A 481
MET A 505
LEU A 561
 None
 1.38A 5dzka-4zxlA:
2.2
5dzko-4zxlA:
undetectable		 5dzka-4zxlA:
15.38
5dzko-4zxlA:
0.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 PHE A 612
SER A 605
HIS A 481
LEU A 561
 None
 1.45A 5dzka-4zxlA:
2.2
5dzko-4zxlA:
undetectable		 5dzka-4zxlA:
15.38
5dzko-4zxlA:
0.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE

(Escherichia
coli) 		PF01790
(LGT) 		4 PHE A   8
SER A 169
PRO A 167
LEU A 165
 None
 1.29A 5dzka-5azbA:
undetectable
5dzko-5azbA:
undetectable		 5dzka-5azbA:
22.58
5dzko-5azbA:
1.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu9 BETA-N-ACETYLHEXOSAM
INIDASE

(Beutenbergia
cavernae) 		PF00933
(Glyco_hydro_3) 		4 PHE A  83
SER A 339
MET A 376
LEU A 365
 None
 1.31A 5dzka-5bu9A:
2.4
5dzko-5bu9A:
undetectable		 5dzka-5bu9A:
20.52
5dzko-5bu9A:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6o HOMOSERINE
O-ACETYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00561
(Abhydrolase_1) 		4 PHE A 244
SER A 211
PRO A 247
LEU A 241
 None
 1.32A 5dzka-5d6oA:
undetectable
5dzko-5d6oA:
undetectable		 5dzka-5d6oA:
22.07
5dzko-5d6oA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		4 PHE A1906
HIS A1914
PRO A1688
LEU A1911
 None
 1.39A 5dzka-5fbyA:
undetectable
5dzko-5fbyA:
undetectable		 5dzka-5fbyA:
16.46
5dzko-5fbyA:
1.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gju ATP-DEPENDENT RNA
HELICASE DEAD

(Escherichia
coli) 		PF00270
(DEAD) 		4 PHE A 166
PRO A 133
MET A 161
LEU A 137
 None
 1.48A 5dzka-5gjuA:
undetectable
5dzko-5gjuA:
undetectable		 5dzka-5gjuA:
22.61
5dzko-5gjuA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		4 HIS A 412
PRO A 393
MET A 334
LEU A 326
 None
None
None
TRS  A 903 (-4.4A)
 1.46A 5dzka-5hp6A:
undetectable
5dzko-5hp6A:
undetectable		 5dzka-5hp6A:
14.05
5dzko-5hp6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0t METHIONINE--TRNA
LIGASE

(Brucella suis) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 PHE A 312
HIS A  23
PRO A  19
MET A  82
 None
 1.32A 5dzka-5k0tA:
undetectable
5dzko-5k0tA:
undetectable		 5dzka-5k0tA:
19.49
5dzko-5k0tA:
1.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 PHE A 153
SER A 129
MET A 194
LEU A 122
 None
 1.47A 5dzka-5vpuA:
undetectable
5dzko-5vpuA:
undetectable		 5dzka-5vpuA:
17.94
5dzko-5vpuA:
1.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 4 SER A  17
HIS A  43
PRO A  15
LEU A   9
 None
 1.20A 5dzka-5y8pA:
2.2
5dzko-5y8pA:
undetectable		 5dzka-5y8pA:
undetectable
5dzko-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 PHE A 488
SER A 469
PRO A 467
LEU A 465
 None
 1.26A 5dzka-5ze4A:
2.4
5dzko-5ze4A:
undetectable		 5dzka-5ze4A:
undetectable
5dzko-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 4 PHE A 414
SER A 499
MET A 449
LEU A 273
 None
 1.47A 5dzka-6at7A:
undetectable
5dzko-6at7A:
undetectable		 5dzka-6at7A:
undetectable
5dzko-6at7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 4 PHE B 291
SER B 273
HIS B 254
LEU B 283
 None
 1.39A 5dzka-6ckcB:
undetectable
5dzko-6ckcB:
undetectable		 5dzka-6ckcB:
undetectable
5dzko-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2d FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIP
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIR

(Salmonella
enterica;
Salmonella
enterica) 		no annotation
no annotation 		4 SER F  34
HIS F 143
MET F 134
LEU A 179
 None
 1.06A 5dzka-6f2dF:
undetectable
5dzko-6f2dF:
undetectable		 5dzka-6f2dF:
undetectable
5dzko-6f2dF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 4 SER A  27
HIS A 171
MET A 138
LEU A 119
 None
QPS  A 601 (-4.2A)
None
None
 1.10A 5dzka-6gngA:
undetectable
5dzko-6gngA:
undetectable		 5dzka-6gngA:
undetectable
5dzko-6gngA:
undetectable