SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_3_BEZ3801_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermococcus
litoralis) 		PF01470
(Peptidase_C15) 		4 LEU A   5
ILE A  66
GLY A  39
ILE A 198
 None
 0.83A 5dzk3-1a2zA:
undetectable
5dzkm-1a2zA:
0.0		 5dzk3-1a2zA:
0.91
5dzkm-1a2zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 310
ILE A 307
GLY A 359
ILE A  48
 None
 0.84A 5dzk3-1bkhA:
undetectable
5dzkm-1bkhA:
3.2		 5dzk3-1bkhA:
15.38
5dzkm-1bkhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu2 CYCLIN HOMOLOG

(Saimiriine
gammaherpesvirus
2) 		PF00134
(Cyclin_N)
PF09241
(Herp-Cyclin) 		4 LEU A  80
ILE A  79
GLY A  98
ILE A 104
 None
 0.81A 5dzk3-1bu2A:
undetectable
5dzkm-1bu2A:
undetectable		 5dzk3-1bu2A:
16.67
5dzkm-1bu2A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2i PROTEIN (RESTRICTION
ENDONUCLEASE BGLII)

(Bacillus
subtilis) 		PF09195
(Endonuc-BglII) 		4 LEU A  91
ILE A 128
GLY A  86
ILE A  23
 None
 0.73A 5dzk3-1d2iA:
undetectable
5dzkm-1d2iA:
undetectable		 5dzk3-1d2iA:
1.94
5dzkm-1d2iA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 LEU A  46
ILE A  47
GLY A  72
ILE A 130
 None
 0.85A 5dzk3-1ddkA:
undetectable
5dzkm-1ddkA:
undetectable		 5dzk3-1ddkA:
1.90
5dzkm-1ddkA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehi D-ALANINE:D-LACTATE
LIGASE

(Leuconostoc
mesenteroides) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 347
ILE A 348
GLY A 124
ILE A  96
 None
 0.85A 5dzk3-1ehiA:
undetectable
5dzkm-1ehiA:
0.0		 5dzk3-1ehiA:
1.69
5dzkm-1ehiA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		4 LEU A 393
ILE A 281
GLY A 307
ILE A 292
 None
 0.87A 5dzk3-1f0xA:
undetectable
5dzkm-1f0xA:
undetectable		 5dzk3-1f0xA:
7.69
5dzkm-1f0xA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		4 LEU A 236
ILE A 233
GLY A 224
ILE A 244
 None
 0.79A 5dzk3-1i2oA:
undetectable
5dzkm-1i2oA:
0.0		 5dzk3-1i2oA:
0.63
5dzkm-1i2oA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 LEU A  48
ILE A 368
GLY A  52
ILE A  60
 FAD  A2457 (-2.9A)
FAD  A2457 (-3.7A)
FAD  A2457 (-3.0A)
FAD  A2457 ( 3.5A)
 0.84A 5dzk3-1lqtA:
undetectable
5dzkm-1lqtA:
0.0		 5dzk3-1lqtA:
8.70
5dzkm-1lqtA:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 LEU A  40
ILE A 103
GLY A 125
ILE A  75
 None
 0.78A 5dzk3-1miqA:
undetectable
5dzkm-1miqA:
undetectable		 5dzk3-1miqA:
33.33
5dzkm-1miqA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A  66
ILE A  67
GLY A 107
ILE A  94
 ANP  A1285 (-4.0A)
ANP  A1285 ( 4.9A)
ANP  A1285 (-3.2A)
None
 0.81A 5dzk3-1oj4A:
undetectable
5dzkm-1oj4A:
undetectable		 5dzk3-1oj4A:
0.71
5dzkm-1oj4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea) 		PF01338
(Bac_thur_toxin) 		4 LEU A 104
ILE A 103
GLY A  76
ILE A  82
 None
 0.74A 5dzk3-1pp0A:
undetectable
5dzkm-1pp0A:
undetectable		 5dzk3-1pp0A:
2.33
5dzkm-1pp0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 LEU A 155
ILE A 159
GLY A 152
ILE A 167
 None
 0.87A 5dzk3-1rt8A:
undetectable
5dzkm-1rt8A:
undetectable		 5dzk3-1rt8A:
1.50
5dzkm-1rt8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlv TRANSCRIPTION
ANTITERMINATOR LICT

(Bacillus
subtilis) 		PF00874
(PRD) 		4 LEU A 158
ILE A 160
GLY A 154
ILE A 132
 None
 0.89A 5dzk3-1tlvA:
undetectable
5dzkm-1tlvA:
undetectable		 5dzk3-1tlvA:
20.00
5dzkm-1tlvA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucv EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF00536
(SAM_1) 		4 LEU A  52
ILE A  50
GLY A  54
ILE A  59
 None
 0.84A 5dzk3-1ucvA:
undetectable
5dzkm-1ucvA:
undetectable		 5dzk3-1ucvA:
14.29
5dzkm-1ucvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atv RAS-LIKE
ESTROGEN-REGULATED
GROWTH INHIBITOR

(Homo sapiens) 		PF00071
(Ras) 		4 LEU A 115
ILE A 114
GLY A 117
ILE A 159
 None
 0.87A 5dzk3-2atvA:
undetectable
5dzkm-2atvA:
undetectable		 5dzk3-2atvA:
2.47
5dzkm-2atvA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		4 LEU A 278
ILE A 279
GLY A 276
ILE A 340
 None
 0.86A 5dzk3-2bf6A:
undetectable
5dzkm-2bf6A:
undetectable		 5dzk3-2bf6A:
1.98
5dzkm-2bf6A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1d TRANSALDOLASE

(Mus musculus) 		PF00923
(TAL_FSA) 		4 LEU A 247
ILE A 244
GLY A 235
ILE A 255
 None
 0.82A 5dzk3-2e1dA:
undetectable
5dzkm-2e1dA:
undetectable		 5dzk3-2e1dA:
0.78
5dzkm-2e1dA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egz 3-DEHYDROQUINATE
DEHYDRATASE

(Aquifex
aeolicus) 		PF01487
(DHquinase_I) 		4 LEU A 169
ILE A 168
GLY A 183
ILE A 190
 None
 0.89A 5dzk3-2egzA:
undetectable
5dzkm-2egzA:
4.7		 5dzk3-2egzA:
0.91
5dzkm-2egzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2c PUTATIVE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN

(Corynebacterium
diphtheriae) 		PF00994
(MoCF_biosynth) 		4 LEU A 132
ILE A  70
GLY A 122
ILE A  59
 None
 0.87A 5dzk3-2g2cA:
undetectable
5dzkm-2g2cA:
undetectable		 5dzk3-2g2cA:
6.67
5dzkm-2g2cA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		4 LEU A  38
ILE A  62
GLY A  11
ILE A  88
 None
 0.68A 5dzk3-2i5bA:
undetectable
5dzkm-2i5bA:
1.9		 5dzk3-2i5bA:
1.35
5dzkm-2i5bA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 LEU A  87
ILE A 113
GLY A   6
ILE A 115
 None
 0.90A 5dzk3-2jjmA:
undetectable
5dzkm-2jjmA:
3.3		 5dzk3-2jjmA:
0.71
5dzkm-2jjmA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nan CD302 ANTIGEN

(Homo sapiens) 		PF00059
(Lectin_C) 		4 LEU A  90
ILE A  89
GLY A  92
ILE A  75
 None
 0.77A 5dzk3-2nanA:
undetectable
5dzkm-2nanA:
undetectable		 5dzk3-2nanA:
2.86
5dzkm-2nanA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 LEU A 188
ILE A 189
GLY A 123
ILE A 130
 None
 0.84A 5dzk3-2nztA:
undetectable
5dzkm-2nztA:
2.3		 5dzk3-2nztA:
8.70
5dzkm-2nztA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		4 LEU A 193
ILE A 223
GLY A 139
ILE A 180
 None
 0.60A 5dzk3-2qvlA:
undetectable
5dzkm-2qvlA:
undetectable		 5dzk3-2qvlA:
0.93
5dzkm-2qvlA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		4 LEU A 309
ILE A 293
GLY A 308
ILE A  56
 None
 0.88A 5dzk3-2rinA:
undetectable
5dzkm-2rinA:
undetectable		 5dzk3-2rinA:
0.88
5dzkm-2rinA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF03308
(ArgK) 		4 LEU A 229
ILE A 228
GLY A 233
ILE A 239
 None
 0.89A 5dzk3-2wwwA:
undetectable
5dzkm-2wwwA:
undetectable		 5dzk3-2wwwA:
3.70
5dzkm-2wwwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 LEU A1199
ILE A1200
GLY A1195
ILE A1466
 None
 0.77A 5dzk3-2xkkA:
undetectable
5dzkm-2xkkA:
undetectable		 5dzk3-2xkkA:
1.49
5dzkm-2xkkA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywj GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Methanocaldococcus
jannaschii) 		PF01174
(SNO) 		4 LEU A  61
ILE A  64
GLY A  52
ILE A  43
 None
 0.90A 5dzk3-2ywjA:
undetectable
5dzkm-2ywjA:
undetectable		 5dzk3-2ywjA:
3.28
5dzkm-2ywjA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb4 PROSTAGLANDIN
REDUCTASE 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 LEU A 109
ILE A 108
GLY A 111
ILE A  34
 None
 0.88A 5dzk3-2zb4A:
undetectable
5dzkm-2zb4A:
undetectable		 5dzk3-2zb4A:
0.56
5dzkm-2zb4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
synthetic
construct) 		PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		4 LEU C 350
ILE C 348
GLY C 416
ILE C 412
 GSU  C1001 (-3.8A)
None
None
None
 0.83A 5dzk3-3al0C:
undetectable
5dzkm-3al0C:
undetectable		 5dzk3-3al0C:
4.65
5dzkm-3al0C:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		4 LEU A 243
ILE A 244
GLY A 222
ILE A 235
 None
 0.82A 5dzk3-3anyA:
undetectable
5dzkm-3anyA:
undetectable		 5dzk3-3anyA:
0.52
5dzkm-3anyA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE

(Enterococcus
faecalis) 		PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2) 		4 LEU A  96
ILE A  97
GLY A  94
ILE A  91
 None
 0.88A 5dzk3-3cj8A:
undetectable
5dzkm-3cj8A:
undetectable		 5dzk3-3cj8A:
0.85
5dzkm-3cj8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 LEU A 554
ILE A 502
GLY A 592
ILE A 526
 None
 0.77A 5dzk3-3eqnA:
undetectable
5dzkm-3eqnA:
undetectable		 5dzk3-3eqnA:
1.60
5dzkm-3eqnA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LEU A 295
ILE A 285
GLY A 297
ILE A 281
 None
 0.88A 5dzk3-3gdeA:
undetectable
5dzkm-3gdeA:
undetectable		 5dzk3-3gdeA:
2.90
5dzkm-3gdeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		4 LEU A  58
ILE A  59
GLY A  27
ILE A  49
 None
 0.87A 5dzk3-3gs6A:
undetectable
5dzkm-3gs6A:
undetectable		 5dzk3-3gs6A:
4.65
5dzkm-3gs6A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 LEU A 110
ILE A 111
GLY A 108
ILE A 101
 None
 0.81A 5dzk3-3h0lA:
undetectable
5dzkm-3h0lA:
undetectable		 5dzk3-3h0lA:
28.57
5dzkm-3h0lA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		4 LEU A 226
ILE A  70
GLY A 228
ILE A   9
 None
 0.86A 5dzk3-3h6eA:
undetectable
5dzkm-3h6eA:
undetectable		 5dzk3-3h6eA:
3.45
5dzkm-3h6eA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		4 LEU A 481
ILE A 463
GLY A 478
ILE A 466
 FMN  A1002 ( 4.9A)
None
FMN  A1002 (-3.7A)
None
 0.87A 5dzk3-3i6rA:
undetectable
5dzkm-3i6rA:
1.7		 5dzk3-3i6rA:
3.03
5dzkm-3i6rA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igx TRANSALDOLASE

(Francisella
tularensis) 		PF00923
(TAL_FSA) 		4 LEU A  89
ILE A  92
GLY A  85
ILE A  25
 None
 0.88A 5dzk3-3igxA:
undetectable
5dzkm-3igxA:
undetectable		 5dzk3-3igxA:
0.62
5dzkm-3igxA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 LEU A1726
ILE A1727
GLY A1740
ILE A1750
 None
 0.90A 5dzk3-3jb9A:
undetectable
5dzkm-3jb9A:
undetectable		 5dzk3-3jb9A:
1.61
5dzkm-3jb9A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 LEU A  52
ILE A 345
GLY A  49
ILE A 389
 None
 0.81A 5dzk3-3lk6A:
undetectable
5dzkm-3lk6A:
undetectable		 5dzk3-3lk6A:
0.32
5dzkm-3lk6A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of5 DETHIOBIOTIN
SYNTHETASE

(Francisella
tularensis) 		PF13500
(AAA_26) 		4 LEU A 142
ILE A 172
GLY A   8
ILE A  18
 None
 0.71A 5dzk3-3of5A:
undetectable
5dzkm-3of5A:
undetectable		 5dzk3-3of5A:
1.63
5dzkm-3of5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION

(Bifidobacterium
adolescentis) 		PF13556
(HTH_30) 		4 LEU A  93
ILE A  85
GLY A  57
ILE A  71
 None
 0.89A 5dzk3-3onqA:
undetectable
5dzkm-3onqA:
undetectable		 5dzk3-3onqA:
1.20
5dzkm-3onqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv2 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 LEU A  91
ILE A  92
GLY A  27
ILE A  86
 None
 0.88A 5dzk3-3pv2A:
undetectable
5dzkm-3pv2A:
undetectable		 5dzk3-3pv2A:
0.61
5dzkm-3pv2A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdf 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Mycobacterium
marinum) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 LEU A 227
ILE A 122
GLY A 225
ILE A 140
 None
 0.87A 5dzk3-3qdfA:
undetectable
5dzkm-3qdfA:
undetectable		 5dzk3-3qdfA:
3.39
5dzkm-3qdfA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 LEU A 222
ILE A 291
GLY A 246
ILE A 231
 None
 0.83A 5dzk3-3tm5A:
undetectable
5dzkm-3tm5A:
undetectable		 5dzk3-3tm5A:
40.00
5dzkm-3tm5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS

(Pyrococcus
furiosus) 		PF08489
(DUF1743) 		4 LEU A   2
ILE A  64
GLY A 100
ILE A  69
 None
 0.84A 5dzk3-3u02A:
undetectable
5dzkm-3u02A:
undetectable		 5dzk3-3u02A:
1.44
5dzkm-3u02A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4g ARGININE REPRESSOR

(Vibrio
vulnificus) 		PF01316
(Arg_repressor)
PF02863
(Arg_repressor_C) 		4 LEU A  85
ILE A 108
GLY A 101
ILE A 131
 None
 0.88A 5dzk3-3v4gA:
undetectable
5dzkm-3v4gA:
undetectable		 5dzk3-3v4gA:
4.76
5dzkm-3v4gA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 LEU L  42
ILE L  12
GLY L  43
ILE L 112
 None
 0.81A 5dzk3-3wxrL:
undetectable
5dzkm-3wxrL:
undetectable		 5dzk3-3wxrL:
1.71
5dzkm-3wxrL:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyh LYSOZYME G

(Struthio
camelus) 		PF01464
(SLT) 		4 LEU A  51
ILE A  52
GLY A 109
ILE A  70
 None
 0.87A 5dzk3-3wyhA:
undetectable
5dzkm-3wyhA:
undetectable		 5dzk3-3wyhA:
2.50
5dzkm-3wyhA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 LEU A  68
ILE A  64
GLY A 178
ILE A 185
 None
 0.90A 5dzk3-4av6A:
undetectable
5dzkm-4av6A:
undetectable		 5dzk3-4av6A:
2.60
5dzkm-4av6A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		4 LEU A 451
ILE A 520
GLY A 347
ILE A 485
 GOL  A1556 (-4.9A)
None
None
None
 0.83A 5dzk3-4be9A:
undetectable
5dzkm-4be9A:
undetectable		 5dzk3-4be9A:
2.47
5dzkm-4be9A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 LEU A 325
ILE A 326
GLY A 275
ILE A 371
 None
 0.88A 5dzk3-4cmnA:
undetectable
5dzkm-4cmnA:
undetectable		 5dzk3-4cmnA:
0.85
5dzkm-4cmnA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus) 		PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel) 		4 LEU A 332
ILE A 331
GLY A 380
ILE A 350
 None
 0.89A 5dzk3-4d2iA:
undetectable
5dzkm-4d2iA:
1.6		 5dzk3-4d2iA:
3.85
5dzkm-4d2iA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4e ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Escherichia
coli) 		PF00227
(Proteasome) 		4 LEU A  95
ILE A 105
GLY A  45
ILE A 120
 None
 0.80A 5dzk3-4g4eA:
undetectable
5dzkm-4g4eA:
undetectable		 5dzk3-4g4eA:
2.11
5dzkm-4g4eA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		4 LEU A 296
ILE A 297
GLY A 292
ILE A 250
 None
 0.87A 5dzk3-4gbrA:
undetectable
5dzkm-4gbrA:
undetectable		 5dzk3-4gbrA:
1.71
5dzkm-4gbrA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		4 LEU A 153
ILE A  13
GLY A 141
ILE A 283
 None
 0.62A 5dzk3-4l6uA:
undetectable
5dzkm-4l6uA:
undetectable		 5dzk3-4l6uA:
0.83
5dzkm-4l6uA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg8 PRE-MRNA-PROCESSING
FACTOR 19

(Homo sapiens) 		PF00400
(WD40) 		4 LEU A 452
ILE A 459
GLY A 453
ILE A 490
 None
 0.79A 5dzk3-4lg8A:
undetectable
5dzkm-4lg8A:
undetectable		 5dzk3-4lg8A:
0.56
5dzkm-4lg8A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 228
ILE A 227
GLY A  36
ILE A 211
 None
 0.87A 5dzk3-4lutA:
undetectable
5dzkm-4lutA:
undetectable		 5dzk3-4lutA:
7.14
5dzkm-4lutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1j CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		4 LEU A  98
ILE A  96
GLY A 159
ILE A 169
 None
 0.88A 5dzk3-4o1jA:
undetectable
5dzkm-4o1jA:
undetectable		 5dzk3-4o1jA:
1.47
5dzkm-4o1jA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		4 LEU A 153
ILE A 154
GLY A 151
ILE A 163
 None
 0.81A 5dzk3-4oecA:
undetectable
5dzkm-4oecA:
3.1		 5dzk3-4oecA:
1.31
5dzkm-4oecA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Mesorhizobium
japonicum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 104
ILE A 101
GLY A  74
ILE A   8
 None
None
None
NAD  A 402 (-4.6A)
 0.86A 5dzk3-4om8A:
undetectable
5dzkm-4om8A:
undetectable		 5dzk3-4om8A:
1.03
5dzkm-4om8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 LEU A 564
ILE A 565
GLY A 594
ILE A 485
 None
 0.79A 5dzk3-4pj3A:
undetectable
5dzkm-4pj3A:
undetectable		 5dzk3-4pj3A:
4.08
5dzkm-4pj3A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		4 LEU A  60
ILE A  57
GLY A 266
ILE A   3
 None
 0.83A 5dzk3-4pvvA:
undetectable
5dzkm-4pvvA:
undetectable		 5dzk3-4pvvA:
7.69
5dzkm-4pvvA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01148
(CTP_transf_1) 		4 LEU A 265
ILE A 268
GLY A  60
ILE A  55
 None
 0.88A 5dzk3-4q2eA:
undetectable
5dzkm-4q2eA:
undetectable		 5dzk3-4q2eA:
0.93
5dzkm-4q2eA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3n MGS-M5

(unidentified) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 117
ILE A  77
GLY A 143
ILE A 100
 None
 0.80A 5dzk3-4q3nA:
undetectable
5dzkm-4q3nA:
undetectable		 5dzk3-4q3nA:
5.88
5dzkm-4q3nA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qv9 PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 LEU K  42
ILE K  12
GLY K  43
ILE K 112
 None
 0.80A 5dzk3-4qv9K:
undetectable
5dzkm-4qv9K:
undetectable		 5dzk3-4qv9K:
4.76
5dzkm-4qv9K:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ttp DEPHOSPHO-COA KINASE

(Legionella
pneumophila) 		PF01121
(CoaE) 		4 LEU A 115
ILE A  36
GLY A  12
ILE A 102
 None
 0.70A 5dzk3-4ttpA:
undetectable
5dzkm-4ttpA:
undetectable		 5dzk3-4ttpA:
1.96
5dzkm-4ttpA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		4 LEU A  52
ILE A  85
GLY A   6
ILE A  12
 None
 0.84A 5dzk3-4twbA:
undetectable
5dzkm-4twbA:
undetectable		 5dzk3-4twbA:
0.69
5dzkm-4twbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzr PUTATIVE
UNCHARACTERIZED
PROTEIN PH1500

(Pyrococcus
horikoshii) 		PF02933
(CDC48_2) 		4 LEU A 108
ILE A 109
GLY A 120
ILE A 146
 None
 0.87A 5dzk3-4uzrA:
undetectable
5dzkm-4uzrA:
undetectable		 5dzk3-4uzrA:
7.69
5dzkm-4uzrA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxk PHYCOBILIPROTEIN
APCE

(Nostoc sp. PCC
7120) 		PF00502
(Phycobilisome) 		4 LEU A  54
ILE A  56
GLY A  50
ILE A 225
 None
 0.80A 5dzk3-4xxkA:
undetectable
5dzkm-4xxkA:
undetectable		 5dzk3-4xxkA:
5.56
5dzkm-4xxkA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Streptobacillus
moniliformis) 		PF13407
(Peripla_BP_4) 		4 LEU A  88
ILE A 113
GLY A  30
ILE A 289
 None
 0.85A 5dzk3-4z0nA:
undetectable
5dzkm-4z0nA:
undetectable		 5dzk3-4z0nA:
2.99
5dzkm-4z0nA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis) 		no annotation 4 LEU A 344
ILE A 573
GLY A 346
ILE A 556
 None
None
FMN  A 900 (-3.4A)
None
 0.85A 5dzk3-4z38A:
undetectable
5dzkm-4z38A:
2.5		 5dzk3-4z38A:
13.33
5dzkm-4z38A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 LEU A  33
ILE A  34
GLY A  29
ILE A  65
 None
 0.90A 5dzk3-4zm6A:
undetectable
5dzkm-4zm6A:
undetectable		 5dzk3-4zm6A:
11.76
5dzkm-4zm6A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 LEU M 241
ILE M 243
GLY M 234
ILE M 208
 None
 0.88A 5dzk3-5a5tM:
undetectable
5dzkm-5a5tM:
undetectable		 5dzk3-5a5tM:
2.82
5dzkm-5a5tM:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3r IMP-18

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A  64
ILE A  65
GLY A  90
ILE A 148
 None
 0.84A 5dzk3-5b3rA:
undetectable
5dzkm-5b3rA:
undetectable		 5dzk3-5b3rA:
1.89
5dzkm-5b3rA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
delbrueckii) 		PF02361
(CbiQ) 		4 LEU D 121
ILE D 119
GLY D  51
ILE D  35
 None
 0.86A 5dzk3-5d3mD:
undetectable
5dzkm-5d3mD:
undetectable		 5dzk3-5d3mD:
7.69
5dzkm-5d3mD:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm4 METHYLTRANSFERASE
DOMAIN FAMILY

(Bacillus
pumilus) 		PF13489
(Methyltransf_23) 		4 LEU A  64
ILE A  63
GLY A  88
ILE A  77
 None
 0.87A 5dzk3-5dm4A:
undetectable
5dzkm-5dm4A:
undetectable		 5dzk3-5dm4A:
1.42
5dzkm-5dm4A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE

(Hirschia
baltica) 		PF00160
(Pro_isomerase) 		4 LEU A  48
ILE A  49
GLY A 189
ILE A 168
 None
 0.85A 5dzk3-5ex1A:
undetectable
5dzkm-5ex1A:
undetectable		 5dzk3-5ex1A:
1.80
5dzkm-5ex1A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 LEU C  70
ILE C 122
GLY C  88
ILE C 451
 None
 0.88A 5dzk3-5fseC:
undetectable
5dzkm-5fseC:
2.3		 5dzk3-5fseC:
2.86
5dzkm-5fseC:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fws KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 LEU A 296
ILE A 252
GLY A 273
ILE A 244
 None
 0.83A 5dzk3-5fwsA:
undetectable
5dzkm-5fwsA:
undetectable		 5dzk3-5fwsA:
15.38
5dzkm-5fwsA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fww KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 LEU B 296
ILE B 252
GLY B 273
ILE B 244
 None
 0.86A 5dzk3-5fwwB:
undetectable
5dzkm-5fwwB:
undetectable		 5dzk3-5fwwB:
0.83
5dzkm-5fwwB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 4 LEU A 161
ILE A 103
GLY A 216
ILE A 168
 None
 0.72A 5dzk3-5gqfA:
undetectable
5dzkm-5gqfA:
undetectable		 5dzk3-5gqfA:
3.28
5dzkm-5gqfA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 LEU A  40
ILE A 103
GLY A 125
ILE A  75
 None
 0.82A 5dzk3-5jodA:
undetectable
5dzkm-5jodA:
undetectable		 5dzk3-5jodA:
0.53
5dzkm-5jodA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 LEU S 169
ILE S 198
GLY S  58
ILE S 190
 None
 0.87A 5dzk3-5k0yS:
undetectable
5dzkm-5k0yS:
undetectable		 5dzk3-5k0yS:
1.68
5dzkm-5k0yS:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB) 		4 LEU A 290
ILE A 435
GLY A 413
ILE A 264
 None
 0.88A 5dzk3-5kwaA:
undetectable
5dzkm-5kwaA:
3.0		 5dzk3-5kwaA:
14.29
5dzkm-5kwaA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhe N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE

(Thermococcus
kodakarensis) 		PF00697
(PRAI) 		4 LEU A 197
ILE A 198
GLY A 186
ILE A   7
 None
 0.85A 5dzk3-5lheA:
undetectable
5dzkm-5lheA:
undetectable		 5dzk3-5lheA:
1.67
5dzkm-5lheA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly6 PNEUMOLYSIN

(Streptococcus
pneumoniae) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 LEU B 327
ILE B 329
GLY B 326
ILE B 198
 None
 0.82A 5dzk3-5ly6B:
undetectable
5dzkm-5ly6B:
undetectable		 5dzk3-5ly6B:
9.52
5dzkm-5ly6B:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 4 LEU A  86
ILE A 151
GLY A 171
ILE A 122
 None
 0.89A 5dzk3-5nfgA:
undetectable
5dzkm-5nfgA:
undetectable		 5dzk3-5nfgA:
25.00
5dzkm-5nfgA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2

(Porphyromonas
gingivalis) 		no annotation 4 LEU B 273
ILE B 281
GLY B 270
ILE B 312
 None
 0.83A 5dzk3-5nfiB:
undetectable
5dzkm-5nfiB:
undetectable		 5dzk3-5nfiB:
undetectable
5dzkm-5nfiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 293
ILE A 292
GLY A 295
ILE A 263
 None
 0.89A 5dzk3-5t88A:
undetectable
5dzkm-5t88A:
undetectable		 5dzk3-5t88A:
2.06
5dzkm-5t88A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE

(Pseudomonas
aeruginosa) 		PF06833
(MdcE) 		4 LEU A 155
ILE A 133
GLY A 246
ILE A 238
 None
 0.89A 5dzk3-5vipA:
undetectable
5dzkm-5vipA:
9.3		 5dzk3-5vipA:
2.44
5dzkm-5vipA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vto BLASTICIDIN M

(Streptomyces
griseochromogenes) 		no annotation 4 LEU A 131
ILE A 106
GLY A 134
ILE A 116
 None
 0.78A 5dzk3-5vtoA:
undetectable
5dzkm-5vtoA:
undetectable		 5dzk3-5vtoA:
undetectable
5dzkm-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 4 LEU A 205
ILE A 204
GLY A 227
ILE A 218
 None
 0.87A 5dzk3-5yf0A:
undetectable
5dzkm-5yf0A:
undetectable		 5dzk3-5yf0A:
undetectable
5dzkm-5yf0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 4 LEU A 437
ILE A 438
GLY A 433
ILE A 450
 None
 0.87A 5dzk3-5yl7A:
undetectable
5dzkm-5yl7A:
2.6		 5dzk3-5yl7A:
undetectable
5dzkm-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 4 LEU P 460
ILE P 456
GLY P 571
ILE P 449
 None
 0.88A 5dzk3-6c1dP:
undetectable
5dzkm-6c1dP:
undetectable		 5dzk3-6c1dP:
undetectable
5dzkm-6c1dP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6d -

(-) 		no annotation 4 LEU A 114
ILE A  86
GLY A 113
ILE A  92
 None
 0.84A 5dzk3-6d6dA:
undetectable
5dzkm-6d6dA:
undetectable		 5dzk3-6d6dA:
undetectable
5dzkm-6d6dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 LEU A 563
ILE A 556
GLY A 561
ILE A 544
 None
 0.89A 5dzk3-6en4A:
undetectable
5dzkm-6en4A:
undetectable		 5dzk3-6en4A:
undetectable
5dzkm-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 LEU A 254
ILE A 257
GLY A 250
ILE A 304
 None
 0.80A 5dzk3-6eu6A:
undetectable
5dzkm-6eu6A:
undetectable		 5dzk3-6eu6A:
undetectable
5dzkm-6eu6A:
undetectable