SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_2_BEZ2801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 LEU A 191
ARG A 225
ILE A 197
ILE A 220
 None
 0.75A 5dzk2-1d0nA:
undetectable
5dzkM-1d0nA:
0.0
5dzkN-1d0nA:
0.0		 5dzk2-1d0nA:
1.46
5dzkM-1d0nA:
14.50
5dzkN-1d0nA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		4 LEU A 195
ARG A 143
ILE A 168
ILE A  39
 None
 1.10A 5dzk2-1eepA:
undetectable
5dzkM-1eepA:
1.2
5dzkN-1eepA:
1.4		 5dzk2-1eepA:
11.76
5dzkM-1eepA:
19.55
5dzkN-1eepA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eke RIBONUCLEASE HII

(Methanocaldococcus
jannaschii) 		PF01351
(RNase_HII) 		4 LEU A  96
ARG A 136
ILE A  97
ILE A 132
 None
 1.30A 5dzk2-1ekeA:
undetectable
5dzkM-1ekeA:
undetectable
5dzkN-1ekeA:
0.0		 5dzk2-1ekeA:
3.57
5dzkM-1ekeA:
21.52
5dzkN-1ekeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hi9 DIPEPTIDE TRANSPORT
PROTEIN DPPA

(Bacillus
subtilis) 		PF04951
(Peptidase_M55) 		4 LEU A  33
ARG A 190
ILE A  34
ILE A  12
 None
 1.19A 5dzk2-1hi9A:
undetectable
5dzkM-1hi9A:
0.9
5dzkN-1hi9A:
0.8		 5dzk2-1hi9A:
1.03
5dzkM-1hi9A:
21.71
5dzkN-1hi9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		4 LEU A 266
ARG A 309
ILE A 267
ILE A  77
 None
 1.23A 5dzk2-1i6qA:
undetectable
5dzkM-1i6qA:
undetectable
5dzkN-1i6qA:
0.0		 5dzk2-1i6qA:
1.52
5dzkM-1i6qA:
15.03
5dzkN-1i6qA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqr VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 LEU A 107
ARG A 117
ILE A 106
ILE A 130
 None
 1.19A 5dzk2-1kqrA:
undetectable
5dzkM-1kqrA:
undetectable
5dzkN-1kqrA:
0.0		 5dzk2-1kqrA:
1.12
5dzkM-1kqrA:
21.88
5dzkN-1kqrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01135
(PCMT) 		4 LEU A  91
ARG A  36
ILE A  90
ILE A  58
 SAH  A 300 ( 4.8A)
None
None
SAH  A 300 (-4.5A)
 1.08A 5dzk2-1kr5A:
undetectable
5dzkM-1kr5A:
0.0
5dzkN-1kr5A:
0.0		 5dzk2-1kr5A:
1.54
5dzkM-1kr5A:
21.62
5dzkN-1kr5A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		4 LEU A 712
ARG A 643
ILE A 751
ILE A 756
 None
 1.42A 5dzk2-1ku1A:
undetectable
5dzkM-1ku1A:
undetectable
5dzkN-1ku1A:
undetectable		 5dzk2-1ku1A:
1.82
5dzkM-1ku1A:
21.90
5dzkN-1ku1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin) 		4 LEU A 200
ARG A 274
ILE A 201
ILE A 187
 None
 0.95A 5dzk2-1ldkA:
undetectable
5dzkM-1ldkA:
0.0
5dzkN-1ldkA:
0.0		 5dzk2-1ldkA:
2.22
5dzkM-1ldkA:
19.24
5dzkN-1ldkA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lme PEPTIDE DEFORMYLASE

(Thermotoga
maritima) 		PF01327
(Pep_deformylase) 		4 LEU A 138
ARG A  99
ILE A 139
ILE A  97
 OCS  A  87 ( 4.8A)
None
OCS  A  87 ( 4.6A)
None
 1.33A 5dzk2-1lmeA:
undetectable
5dzkM-1lmeA:
undetectable
5dzkN-1lmeA:
undetectable		 5dzk2-1lmeA:
1.23
5dzkM-1lmeA:
21.60
5dzkN-1lmeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF01798
(Nop) 		4 LEU B 109
ARG B 132
ILE B 128
ILE B 102
 None
 1.13A 5dzk2-1nt2B:
undetectable
5dzkM-1nt2B:
undetectable
5dzkN-1nt2B:
undetectable		 5dzk2-1nt2B:
1.29
5dzkM-1nt2B:
22.10
5dzkN-1nt2B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		4 LEU A 405
ARG A 186
ILE A 406
ILE A 369
 None
 1.39A 5dzk2-1pk8A:
undetectable
5dzkM-1pk8A:
undetectable
5dzkN-1pk8A:
undetectable		 5dzk2-1pk8A:
1.69
5dzkM-1pk8A:
19.01
5dzkN-1pk8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 LEU G 191
ARG G 225
ILE G 197
ILE G 220
 None
 0.72A 5dzk2-1rgiG:
undetectable
5dzkM-1rgiG:
undetectable
5dzkN-1rgiG:
undetectable		 5dzk2-1rgiG:
1.45
5dzkM-1rgiG:
19.43
5dzkN-1rgiG:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vec ATP-DEPENDENT RNA
HELICASE P54

(Homo sapiens) 		PF00270
(DEAD) 		4 LEU A 126
ARG A 123
ILE A 125
ILE A 118
 None
 1.22A 5dzk2-1vecA:
undetectable
5dzkM-1vecA:
undetectable
5dzkN-1vecA:
undetectable		 5dzk2-1vecA:
13.33
5dzkM-1vecA:
21.55
5dzkN-1vecA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7w NUCLEOSIDE
DIPHOSPHATE KINASE

(Pisum sativum) 		PF00334
(NDK) 		4 LEU A  89
ARG A 104
ILE A 103
ILE A 116
 None
 1.09A 5dzk2-1w7wA:
undetectable
5dzkM-1w7wA:
undetectable
5dzkN-1w7wA:
undetectable		 5dzk2-1w7wA:
3.17
5dzkM-1w7wA:
21.59
5dzkN-1w7wA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 363
ARG A 257
ILE A 364
ILE A 259
 LEU  A 363 ( 0.6A)
ARG  A 257 ( 0.6A)
ILE  A 364 ( 0.7A)
ILE  A 259 ( 0.4A)
 1.38A 5dzk2-1wqaA:
undetectable
5dzkM-1wqaA:
undetectable
5dzkN-1wqaA:
undetectable		 5dzk2-1wqaA:
5.88
5dzkM-1wqaA:
18.86
5dzkN-1wqaA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x79 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF03127
(GAT) 		4 LEU A 281
ARG A 214
ILE A 280
ILE A 218
 None
 1.39A 5dzk2-1x79A:
undetectable
5dzkM-1x79A:
undetectable
5dzkN-1x79A:
undetectable		 5dzk2-1x79A:
8.33
5dzkM-1x79A:
20.83
5dzkN-1x79A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4

(Viscum album) 		PF00161
(RIP) 		4 LEU A 181
ARG A 148
ILE A 123
ILE A 152
 None
 1.37A 5dzk2-1yf8A:
undetectable
5dzkM-1yf8A:
undetectable
5dzkN-1yf8A:
undetectable		 5dzk2-1yf8A:
8.33
5dzkM-1yf8A:
24.02
5dzkN-1yf8A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Streptococcus
pyogenes) 		PF04131
(NanE) 		4 LEU A 136
ARG A 114
ILE A 124
ILE A 120
 None
 1.33A 5dzk2-1yxyA:
undetectable
5dzkM-1yxyA:
undetectable
5dzkN-1yxyA:
undetectable		 5dzk2-1yxyA:
1.47
5dzkM-1yxyA:
26.72
5dzkN-1yxyA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zd1 SULFOTRANSFERASE 4A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 LEU A  96
ARG A 106
ILE A  99
ILE A 108
 None
 1.10A 5dzk2-1zd1A:
undetectable
5dzkM-1zd1A:
undetectable
5dzkN-1zd1A:
undetectable		 5dzk2-1zd1A:
0.70
5dzkM-1zd1A:
21.00
5dzkN-1zd1A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1l PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
BETA ISOFORM

(Rattus
norvegicus) 		PF02121
(IP_trans) 		4 LEU A 228
ARG A 170
ILE A 232
ILE A 236
 None
 1.41A 5dzk2-2a1lA:
undetectable
5dzkM-2a1lA:
undetectable
5dzkN-2a1lA:
undetectable		 5dzk2-2a1lA:
20.00
5dzkM-2a1lA:
21.00
5dzkN-2a1lA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6e RNA POLYMERASE SIGMA
FACTOR RPOD

(Thermus
thermophilus) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		4 LEU F 122
ARG F 128
ILE F 127
ILE F 113
 None
 1.36A 5dzk2-2a6eF:
undetectable
5dzkM-2a6eF:
undetectable
5dzkN-2a6eF:
undetectable		 5dzk2-2a6eF:
3.85
5dzkM-2a6eF:
20.10
5dzkN-2a6eF:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ako GLUTAMATE 5-KINASE

(Campylobacter
jejuni) 		PF00696
(AA_kinase) 		4 LEU A 123
ARG A   3
ILE A  41
ILE A 114
 None
 1.43A 5dzk2-2akoA:
undetectable
5dzkM-2akoA:
undetectable
5dzkN-2akoA:
undetectable		 5dzk2-2akoA:
1.27
5dzkM-2akoA:
21.91
5dzkN-2akoA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		4 LEU A  70
ARG A  58
ILE A  69
ILE A  63
 None
 0.84A 5dzk2-2bi3A:
undetectable
5dzkM-2bi3A:
undetectable
5dzkN-2bi3A:
undetectable		 5dzk2-2bi3A:
7.41
5dzkM-2bi3A:
20.27
5dzkN-2bi3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Prosthecochloris
vibrioformis) 		PF00490
(ALAD) 		4 LEU A 195
ARG A 176
ILE A 194
ILE A 177
 None
MG  A1329 (-4.2A)
None
None
 1.37A 5dzk2-2c1hA:
undetectable
5dzkM-2c1hA:
1.0
5dzkN-2c1hA:
undetectable		 5dzk2-2c1hA:
28.57
5dzkM-2c1hA:
21.82
5dzkN-2c1hA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE

(Bacillus
subtilis) 		PF12710
(HAD) 		4 LEU A 109
ARG A  82
ILE A  77
ILE A 113
 None
 1.33A 5dzk2-2feaA:
undetectable
5dzkM-2feaA:
undetectable
5dzkN-2feaA:
undetectable		 5dzk2-2feaA:
1.80
5dzkM-2feaA:
21.51
5dzkN-2feaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtl HEMOGLOBIN LINKER
CHAIN L1
EXTRACELLULAR
HEMOGLOBIN LINKER L3
SUBUNIT

(Lumbricus
terrestris;
Lumbricus
terrestris) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C)
PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		4 LEU M  28
ARG O  20
ILE O  24
ILE M  21
 None
 1.17A 5dzk2-2gtlM:
undetectable
5dzkM-2gtlM:
undetectable
5dzkN-2gtlM:
undetectable		 5dzk2-2gtlM:
2.74
5dzkM-2gtlM:
21.61
5dzkN-2gtlM:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvh AGR_L_2016P

(Agrobacterium
fabrum) 		PF03061
(4HBT) 		4 LEU A  19
ARG A  53
ILE A  49
ILE A 209
 None
 1.32A 5dzk2-2gvhA:
undetectable
5dzkM-2gvhA:
undetectable
5dzkN-2gvhA:
undetectable		 5dzk2-2gvhA:
1.34
5dzkM-2gvhA:
22.83
5dzkN-2gvhA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A 844
ARG A 847
ILE A 858
ILE A 643
 None
 1.04A 5dzk2-2iukA:
undetectable
5dzkM-2iukA:
undetectable
5dzkN-2iukA:
undetectable		 5dzk2-2iukA:
1.08
5dzkM-2iukA:
12.33
5dzkN-2iukA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oum 50S RIBOSOMAL
PROTEIN L1

(Thermus
thermophilus) 		PF00687
(Ribosomal_L1) 		4 LEU A 185
ARG A 190
ILE A 189
ILE A  22
 None
 1.14A 5dzk2-2oumA:
undetectable
5dzkM-2oumA:
undetectable
5dzkN-2oumA:
undetectable		 5dzk2-2oumA:
18.18
5dzkM-2oumA:
19.91
5dzkN-2oumA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		4 LEU A1037
ARG A1030
ILE A1034
ILE A1092
 None
 1.39A 5dzk2-2oxfA:
undetectable
5dzkM-2oxfA:
undetectable
5dzkN-2oxfA:
undetectable		 5dzk2-2oxfA:
0.80
5dzkM-2oxfA:
21.62
5dzkN-2oxfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3j VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 LEU A 107
ARG A 117
ILE A 106
ILE A 130
 None
 1.22A 5dzk2-2p3jA:
undetectable
5dzkM-2p3jA:
undetectable
5dzkN-2p3jA:
undetectable		 5dzk2-2p3jA:
1.24
5dzkM-2p3jA:
20.49
5dzkN-2p3jA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pia PHTHALATE
DIOXYGENASE
REDUCTASE

(Burkholderia
cepacia) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 258
ARG A 311
ILE A 257
ILE A 251
 None
 1.23A 5dzk2-2piaA:
undetectable
5dzkM-2piaA:
undetectable
5dzkN-2piaA:
undetectable		 5dzk2-2piaA:
0.62
5dzkM-2piaA:
20.67
5dzkN-2piaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		4 LEU A 666
ARG A 517
ILE A 520
ILE A 430
 None
 1.25A 5dzk2-2r05A:
undetectable
5dzkM-2r05A:
undetectable
5dzkN-2r05A:
undetectable		 5dzk2-2r05A:
2.94
5dzkM-2r05A:
14.98
5dzkN-2r05A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN

(Methanocaldococcus
jannaschii) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 LEU C  60
ARG C  58
ILE C  55
ILE C  77
 None
 1.42A 5dzk2-2v3cC:
undetectable
5dzkM-2v3cC:
undetectable
5dzkN-2v3cC:
undetectable		 5dzk2-2v3cC:
2.35
5dzkM-2v3cC:
20.75
5dzkN-2v3cC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Thermus
thermophilus) 		PF09488
(Osmo_MPGsynth) 		4 LEU A  83
ARG A 109
ILE A  82
ILE A  76
 None
 1.32A 5dzk2-2wvlA:
undetectable
5dzkM-2wvlA:
undetectable
5dzkN-2wvlA:
undetectable		 5dzk2-2wvlA:
2.90
5dzkM-2wvlA:
19.85
5dzkN-2wvlA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		4 LEU A  46
ARG A 262
ILE A  94
ILE A 280
 None
 1.23A 5dzk2-3a18A:
undetectable
5dzkM-3a18A:
undetectable
5dzkN-3a18A:
undetectable		 5dzk2-3a18A:
6.90
5dzkM-3a18A:
18.09
5dzkN-3a18A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A 154
ARG A 107
ILE A 106
ILE A 114
 None
 1.29A 5dzk2-3buzA:
undetectable
5dzkM-3buzA:
undetectable
5dzkN-3buzA:
undetectable		 5dzk2-3buzA:
1.29
5dzkM-3buzA:
17.92
5dzkN-3buzA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE

(Helicobacter
pylori) 		PF01761
(DHQ_synthase) 		4 LEU A  30
ARG A  73
ILE A  74
ILE A  59
 None
 1.09A 5dzk2-3clhA:
undetectable
5dzkM-3clhA:
undetectable
5dzkN-3clhA:
undetectable		 5dzk2-3clhA:
4.35
5dzkM-3clhA:
22.32
5dzkN-3clhA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		4 LEU A 212
ARG A 233
ILE A 250
ILE A 285
 None
 1.36A 5dzk2-3e3xA:
undetectable
5dzkM-3e3xA:
undetectable
5dzkN-3e3xA:
undetectable		 5dzk2-3e3xA:
1.04
5dzkM-3e3xA:
20.00
5dzkN-3e3xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb2 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Rhodopseudomonas
palustris) 		PF00701
(DHDPS) 		4 LEU A 154
ARG A 172
ILE A 151
ILE A 176
 None
 1.29A 5dzk2-3eb2A:
undetectable
5dzkM-3eb2A:
1.9
5dzkN-3eb2A:
1.9		 5dzk2-3eb2A:
1.15
5dzkM-3eb2A:
20.39
5dzkN-3eb2A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 640
ARG A1081
ILE A 643
ILE A1069
 None
 1.35A 5dzk2-3f2bA:
undetectable
5dzkM-3f2bA:
undetectable
5dzkN-3f2bA:
undetectable		 5dzk2-3f2bA:
4.88
5dzkM-3f2bA:
11.51
5dzkN-3f2bA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz5 POSSIBLE
2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE

(Rhodobacter
sphaeroides) 		PF01323
(DSBA) 		4 LEU A 175
ARG A  31
ILE A   4
ILE A 194
 None
 0.99A 5dzk2-3fz5A:
undetectable
5dzkM-3fz5A:
undetectable
5dzkN-3fz5A:
undetectable		 5dzk2-3fz5A:
1.36
5dzkM-3fz5A:
22.02
5dzkN-3fz5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlz UNCHARACTERIZED
PROTEIN BT_1490

(Bacteroides
thetaiotaomicron) 		PF12712
(DUF3805)
PF12713
(DUF3806) 		4 LEU A 222
ARG A 132
ILE A 223
ILE A   7
 None
 1.19A 5dzk2-3hlzA:
undetectable
5dzkM-3hlzA:
undetectable
5dzkN-3hlzA:
undetectable		 5dzk2-3hlzA:
1.35
5dzkM-3hlzA:
22.47
5dzkN-3hlzA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inp D-RIBULOSE-PHOSPHATE
3-EPIMERASE

(Francisella
tularensis) 		PF00834
(Ribul_P_3_epim) 		4 LEU A 173
ARG A 170
ILE A 172
ILE A 133
 None
 1.32A 5dzk2-3inpA:
undetectable
5dzkM-3inpA:
undetectable
5dzkN-3inpA:
undetectable		 5dzk2-3inpA:
1.01
5dzkM-3inpA:
22.40
5dzkN-3inpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 388
ARG A 147
ILE A 157
ILE A 152
 None
 0.94A 5dzk2-3kdnA:
undetectable
5dzkM-3kdnA:
1.1
5dzkN-3kdnA:
1.1		 5dzk2-3kdnA:
1.90
5dzkM-3kdnA:
19.38
5dzkN-3kdnA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 LEU A 258
ARG A 289
ILE A 291
ILE A 286
 None
 1.11A 5dzk2-3m07A:
undetectable
5dzkM-3m07A:
undetectable
5dzkN-3m07A:
undetectable		 5dzk2-3m07A:
1.04
5dzkM-3m07A:
15.81
5dzkN-3m07A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr7 ADENYLATE/GUANYLATE
CYCLASE/HYDROLASE,
ALPHA/BETA FOLD
FAMILY

(Ruegeria
pomeroyi) 		PF00211
(Guanylate_cyc) 		4 LEU A   8
ARG A  34
ILE A  42
ILE A  49
 None
 1.33A 5dzk2-3mr7A:
undetectable
5dzkM-3mr7A:
undetectable
5dzkN-3mr7A:
undetectable		 5dzk2-3mr7A:
2.82
5dzkM-3mr7A:
23.29
5dzkN-3mr7A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		4 LEU A 202
ARG A 217
ILE A 216
ILE A 248
 None
 1.24A 5dzk2-3mznA:
undetectable
5dzkM-3mznA:
1.6
5dzkN-3mznA:
0.8		 5dzk2-3mznA:
8.70
5dzkM-3mznA:
18.75
5dzkN-3mznA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		4 LEU A 124
ARG A 102
ILE A  98
ILE A 111
 None
 1.29A 5dzk2-3nm1A:
undetectable
5dzkM-3nm1A:
undetectable
5dzkN-3nm1A:
undetectable		 5dzk2-3nm1A:
0.64
5dzkM-3nm1A:
16.82
5dzkN-3nm1A:
16.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qgu LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF00155
(Aminotran_1_2) 		4 LEU A 394
ARG A 432
ILE A 399
ILE A  72
 None
 1.29A 5dzk2-3qguA:
undetectable
5dzkM-3qguA:
undetectable
5dzkN-3qguA:
undetectable		 5dzk2-3qguA:
33.33
5dzkM-3qguA:
17.46
5dzkN-3qguA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr8 OLIGORIBONUCLEASE

(Coxiella
burnetii) 		PF00929
(RNase_T) 		4 LEU A  40
ARG A 172
ILE A  39
ILE A 168
 None
 1.36A 5dzk2-3tr8A:
undetectable
5dzkM-3tr8A:
undetectable
5dzkN-3tr8A:
undetectable		 5dzk2-3tr8A:
2.67
5dzkM-3tr8A:
24.66
5dzkN-3tr8A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Roseiflexus sp.
RS-1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 200
ARG A 187
ILE A 188
ILE A 168
 None
 0.96A 5dzk2-3u9iA:
undetectable
5dzkM-3u9iA:
2.0
5dzkN-3u9iA:
undetectable		 5dzk2-3u9iA:
0.51
5dzkM-3u9iA:
21.93
5dzkN-3u9iA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 LEU A 123
ARG A 172
ILE A 127
ILE A 174
 None
 1.36A 5dzk2-3vc7A:
undetectable
5dzkM-3vc7A:
undetectable
5dzkN-3vc7A:
1.7		 5dzk2-3vc7A:
1.18
5dzkM-3vc7A:
26.24
5dzkN-3vc7A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1y MICROTUBULE-ASSOCIAT
ED PROTEIN 1A/1B,
LIGHT CHAIN 3

(Trypanosoma
brucei) 		PF02991
(Atg8) 		4 LEU A 102
ARG A 115
ILE A  98
ILE A 112
 None
 1.20A 5dzk2-3w1yA:
undetectable
5dzkM-3w1yA:
undetectable
5dzkN-3w1yA:
undetectable		 5dzk2-3w1yA:
2.78
5dzkM-3w1yA:
21.00
5dzkN-3w1yA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		4 LEU A 549
ARG A 458
ILE A 466
ILE A 463
 None
 1.24A 5dzk2-3welA:
undetectable
5dzkM-3welA:
undetectable
5dzkN-3welA:
undetectable		 5dzk2-3welA:
3.12
5dzkM-3welA:
12.60
5dzkN-3welA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 LEU A   8
ARG A 180
ILE A   6
ILE A 178
 None
 1.25A 5dzk2-4acaA:
undetectable
5dzkM-4acaA:
undetectable
5dzkN-4acaA:
undetectable		 5dzk2-4acaA:
0.44
5dzkM-4acaA:
18.48
5dzkN-4acaA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU A 468
ARG A 507
ILE A 528
ILE A 499
 None
 1.25A 5dzk2-4acqA:
undetectable
5dzkM-4acqA:
undetectable
5dzkN-4acqA:
undetectable		 5dzk2-4acqA:
12.50
5dzkM-4acqA:
9.29
5dzkN-4acqA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		4 LEU A 381
ARG A 397
ILE A 379
ILE A 393
 None
 1.03A 5dzk2-4conA:
undetectable
5dzkM-4conA:
2.1
5dzkN-4conA:
2.1		 5dzk2-4conA:
10.53
5dzkM-4conA:
15.11
5dzkN-4conA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		4 LEU P 381
ARG P 511
ILE P 380
ILE P 514
 None
 1.41A 5dzk2-4crmP:
undetectable
5dzkM-4crmP:
undetectable
5dzkN-4crmP:
1.6		 5dzk2-4crmP:
1.05
5dzkM-4crmP:
15.99
5dzkN-4crmP:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00621
(RhoGEF) 		4 LEU A2006
ARG A1999
ILE A2003
ILE A2078
 None
 1.41A 5dzk2-4d0oA:
undetectable
5dzkM-4d0oA:
undetectable
5dzkN-4d0oA:
undetectable		 5dzk2-4d0oA:
3.03
5dzkM-4d0oA:
21.62
5dzkN-4d0oA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxw ION TRANSPORT
PROTEIN

(alpha
proteobacterium
HIMB114) 		PF00520
(Ion_trans) 		4 LEU A  47
ARG A 111
ILE A  51
ILE A  22
 None
 1.18A 5dzk2-4dxwA:
undetectable
5dzkM-4dxwA:
undetectable
5dzkN-4dxwA:
undetectable		 5dzk2-4dxwA:
1.92
5dzkM-4dxwA:
21.29
5dzkN-4dxwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 173
ARG A  67
ILE A 141
ILE A  64
 None
 1.03A 5dzk2-4e3cA:
undetectable
5dzkM-4e3cA:
undetectable
5dzkN-4e3cA:
undetectable		 5dzk2-4e3cA:
9.52
5dzkM-4e3cA:
14.95
5dzkN-4e3cA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		4 LEU A 273
ARG A 374
ILE A 275
ILE A 370
 None
 1.19A 5dzk2-4eb5A:
undetectable
5dzkM-4eb5A:
undetectable
5dzkN-4eb5A:
undetectable		 5dzk2-4eb5A:
0.58
5dzkM-4eb5A:
19.74
5dzkN-4eb5A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 155
ARG A  60
ILE A 156
ILE A 142
 None
 1.14A 5dzk2-4f7kA:
undetectable
5dzkM-4f7kA:
undetectable
5dzkN-4f7kA:
undetectable		 5dzk2-4f7kA:
0.78
5dzkM-4f7kA:
18.18
5dzkN-4f7kA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		4 LEU A 396
ARG A 434
ILE A 401
ILE A  73
 None
 1.23A 5dzk2-4fl0A:
undetectable
5dzkM-4fl0A:
undetectable
5dzkN-4fl0A:
undetectable		 5dzk2-4fl0A:
1.32
5dzkM-4fl0A:
18.34
5dzkN-4fl0A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 LEU A 524
ARG A 567
ILE A 525
ILE A 441
 None
 1.28A 5dzk2-4flnA:
undetectable
5dzkM-4flnA:
undetectable
5dzkN-4flnA:
undetectable		 5dzk2-4flnA:
2.30
5dzkM-4flnA:
16.35
5dzkN-4flnA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		4 LEU A 399
ARG A 286
ILE A 401
ILE A 288
 None
 1.08A 5dzk2-4go4A:
undetectable
5dzkM-4go4A:
undetectable
5dzkN-4go4A:
undetectable		 5dzk2-4go4A:
2.94
5dzkM-4go4A:
17.92
5dzkN-4go4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 LEU A  47
ARG A  68
ILE A  48
ILE A  74
 None
 0.96A 5dzk2-4hjlA:
undetectable
5dzkM-4hjlA:
undetectable
5dzkN-4hjlA:
undetectable		 5dzk2-4hjlA:
0.52
5dzkM-4hjlA:
19.60
5dzkN-4hjlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxi KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		4 LEU A 104
ARG A  44
ILE A 105
ILE A  61
 None
 1.33A 5dzk2-4hxiA:
undetectable
5dzkM-4hxiA:
undetectable
5dzkN-4hxiA:
undetectable		 5dzk2-4hxiA:
1.18
5dzkM-4hxiA:
21.43
5dzkN-4hxiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maf ATP SULFURYLASE

(Glycine max) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  49
ARG A 381
ILE A  50
ILE A 338
 None
 1.29A 5dzk2-4mafA:
undetectable
5dzkM-4mafA:
undetectable
5dzkN-4mafA:
undetectable		 5dzk2-4mafA:
20.00
5dzkM-4mafA:
21.46
5dzkN-4mafA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 202
ARG A 233
ILE A 203
ILE A 229
 None
 1.42A 5dzk2-4nfyA:
undetectable
5dzkM-4nfyA:
undetectable
5dzkN-4nfyA:
undetectable		 5dzk2-4nfyA:
1.08
5dzkM-4nfyA:
20.85
5dzkN-4nfyA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 4 LEU B 398
ARG B 256
ILE B 255
ILE B 281
 None
 1.18A 5dzk2-4p37B:
undetectable
5dzkM-4p37B:
undetectable
5dzkN-4p37B:
undetectable		 5dzk2-4p37B:
0.98
5dzkM-4p37B:
16.48
5dzkN-4p37B:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 LEU A  66
ARG A 103
ILE A  64
ILE A  61
 None
 1.31A 5dzk2-4pj3A:
undetectable
5dzkM-4pj3A:
undetectable
5dzkN-4pj3A:
undetectable		 5dzk2-4pj3A:
4.08
5dzkM-4pj3A:
8.86
5dzkN-4pj3A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s10 GELSOLIN

(Homo sapiens) 		PF00626
(Gelsolin) 		4 LEU C 191
ARG C 225
ILE C 197
ILE C 220
 None
 0.76A 5dzk2-4s10C:
undetectable
5dzkM-4s10C:
undetectable
5dzkN-4s10C:
undetectable		 5dzk2-4s10C:
6.06
5dzkM-4s10C:
20.42
5dzkN-4s10C:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwv AMINOPEPTIDASE FROM
FAMILY M42

(Desulfurococcus
amylolyticus) 		PF05343
(Peptidase_M42) 		4 LEU A 173
ARG A   6
ILE A 178
ILE A  10
 None
 1.40A 5dzk2-4wwvA:
undetectable
5dzkM-4wwvA:
undetectable
5dzkN-4wwvA:
undetectable		 5dzk2-4wwvA:
1.57
5dzkM-4wwvA:
20.10
5dzkN-4wwvA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 LEU A 946
ARG A1000
ILE A 943
ILE A 940
 None
 1.35A 5dzk2-5a22A:
undetectable
5dzkM-5a22A:
undetectable
5dzkN-5a22A:
undetectable		 5dzk2-5a22A:
1.11
5dzkM-5a22A:
6.59
5dzkN-5a22A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7z UNCHARACTERIZED
PROTEIN TM_0416

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		4 LEU A 180
ARG A 115
ILE A 148
ILE A 159
 None
 1.06A 5dzk2-5b7zA:
undetectable
5dzkM-5b7zA:
undetectable
5dzkN-5b7zA:
undetectable		 5dzk2-5b7zA:
1.27
5dzkM-5b7zA:
21.40
5dzkN-5b7zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i CALCINEURIN SUBUNIT
B, VARIANT

(Coccidioides
immitis) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 LEU B 112
ARG B  57
ILE B 114
ILE B 101
 None
 1.36A 5dzk2-5b8iB:
undetectable
5dzkM-5b8iB:
undetectable
5dzkN-5b8iB:
undetectable		 5dzk2-5b8iB:
4.35
5dzkM-5b8iB:
24.40
5dzkN-5b8iB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buv PUTATIVE EPIMERASE

(Yersinia
enterocolitica) 		PF00908
(dTDP_sugar_isom) 		4 LEU A   8
ARG A  90
ILE A  10
ILE A 118
 None
 1.31A 5dzk2-5buvA:
undetectable
5dzkM-5buvA:
undetectable
5dzkN-5buvA:
undetectable		 5dzk2-5buvA:
2.56
5dzkM-5buvA:
19.90
5dzkN-5buvA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2f BETA-LACTAMASE YBXI

(Bacillus
subtilis) 		PF00905
(Transpeptidase) 		4 LEU A  87
ARG A 140
ILE A  85
ILE A 136
 None
 1.25A 5dzk2-5e2fA:
undetectable
5dzkM-5e2fA:
undetectable
5dzkN-5e2fA:
undetectable		 5dzk2-5e2fA:
14.29
5dzkM-5e2fA:
20.15
5dzkN-5e2fA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5faf GELSOLIN

(Homo sapiens) 		PF00626
(Gelsolin) 		4 LEU A 191
ARG A 225
ILE A 197
ILE A 220
 None
None
None
GOL  A 302 (-4.3A)
 0.65A 5dzk2-5fafA:
undetectable
5dzkM-5fafA:
undetectable
5dzkN-5fafA:
undetectable		 5dzk2-5fafA:
4.55
5dzkM-5fafA:
19.80
5dzkN-5fafA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 130
ARG A 266
ILE A 129
ILE A 263
 None
 1.23A 5dzk2-5fkuA:
undetectable
5dzkM-5fkuA:
undetectable
5dzkN-5fkuA:
undetectable		 5dzk2-5fkuA:
2.60
5dzkM-5fkuA:
10.50
5dzkN-5fkuA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6

(Homo sapiens) 		PF07571
(TAF6_C) 		4 LEU J 304
ARG J 354
ILE J 305
ILE J 351
 None
 1.29A 5dzk2-5furJ:
undetectable
5dzkM-5furJ:
undetectable
5dzkN-5furJ:
undetectable		 5dzk2-5furJ:
5.13
5dzkM-5furJ:
13.74
5dzkN-5furJ:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmn AAC3-I

(uncultured
bacterium) 		PF00583
(Acetyltransf_1) 		4 LEU A  72
ARG A 113
ILE A  82
ILE A  53
 None
 1.34A 5dzk2-5hmnA:
undetectable
5dzkM-5hmnA:
undetectable
5dzkN-5hmnA:
undetectable		 5dzk2-5hmnA:
4.08
5dzkM-5hmnA:
22.64
5dzkN-5hmnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1

(Avena sativa;
Homo sapiens) 		PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13) 		4 LEU B1549
ARG B1302
ILE B1458
ILE B1461
 None
 1.34A 5dzk2-5hzkB:
undetectable
5dzkM-5hzkB:
undetectable
5dzkN-5hzkB:
undetectable		 5dzk2-5hzkB:
12.50
5dzkM-5hzkB:
17.60
5dzkN-5hzkB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2u CELLULASE

(soil metagenome) 		PF00150
(Cellulase) 		4 LEU A 173
ARG A 164
ILE A 197
ILE A 160
 None
 1.04A 5dzk2-5i2uA:
undetectable
5dzkM-5i2uA:
1.8
5dzkN-5i2uA:
undetectable		 5dzk2-5i2uA:
0.67
5dzkM-5i2uA:
21.56
5dzkN-5i2uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsj KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG

(Homo sapiens;
Homo sapiens) 		PF08202
(MIS13)
no annotation 		4 LEU N 148
ARG D 242
ILE N 147
ILE D 239
 None
 0.94A 5dzk2-5lsjN:
undetectable
5dzkM-5lsjN:
undetectable
5dzkN-5lsjN:
undetectable		 5dzk2-5lsjN:
0.86
5dzkM-5lsjN:
20.11
5dzkN-5lsjN:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9o PLASTID DIVISION
PROTEIN CDP1,
CHLOROPLASTIC,PLASTI
D DIVISION PROTEIN
PDV1

(Arabidopsis
thaliana) 		no annotation 4 LEU A 772
ARG A 855
ILE A 796
ILE A 815
 None
 1.33A 5dzk2-5u9oA:
undetectable
5dzkM-5u9oA:
undetectable
5dzkN-5u9oA:
undetectable		 5dzk2-5u9oA:
undetectable
5dzkM-5u9oA:
undetectable
5dzkN-5u9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		PF13281
(DUF4071) 		4 LEU A 277
ARG A 302
ILE A 276
ILE A 299
 None
 1.42A 5dzk2-5ulmA:
undetectable
5dzkM-5ulmA:
undetectable
5dzkN-5ulmA:
undetectable		 5dzk2-5ulmA:
3.77
5dzkM-5ulmA:
19.90
5dzkN-5ulmA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 LEU A 808
ARG A 736
ILE A 805
ILE A 740
 None
 1.11A 5dzk2-5wlhA:
undetectable
5dzkM-5wlhA:
undetectable
5dzkN-5wlhA:
undetectable		 5dzk2-5wlhA:
0.99
5dzkM-5wlhA:
9.62
5dzkN-5wlhA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		4 LEU A 235
ARG A 467
ILE A 231
ILE A 248
 None
 0.94A 5dzk2-5xhqA:
undetectable
5dzkM-5xhqA:
undetectable
5dzkN-5xhqA:
undetectable		 5dzk2-5xhqA:
13.33
5dzkM-5xhqA:
18.54
5dzkN-5xhqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 4 LEU A  79
ARG A  84
ILE A  80
ILE A  62
 None
 1.32A 5dzk2-6c8zA:
undetectable
5dzkM-6c8zA:
undetectable
5dzkN-6c8zA:
undetectable		 5dzk2-6c8zA:
undetectable
5dzkM-6c8zA:
undetectable
5dzkN-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 4 LEU D 289
ARG D 284
ILE D 273
ILE D 256
 None
 1.10A 5dzk2-6cg0D:
undetectable
5dzkM-6cg0D:
undetectable
5dzkN-6cg0D:
undetectable		 5dzk2-6cg0D:
undetectable
5dzkM-6cg0D:
undetectable
5dzkN-6cg0D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwp RIBONUCLEOTIDE
REDUCTASE

(Flavobacterium
johnsoniae) 		no annotation 4 LEU A  61
ARG A 129
ILE A 126
ILE A 239
 None
 1.41A 5dzk2-6cwpA:
undetectable
5dzkM-6cwpA:
undetectable
5dzkN-6cwpA:
undetectable		 5dzk2-6cwpA:
undetectable
5dzkM-6cwpA:
undetectable
5dzkN-6cwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens) 		no annotation 4 LEU A 280
ARG A 311
ILE A 307
ILE A 272
 None
None
FAD  A 601 (-4.6A)
FAD  A 601 ( 4.6A)
 1.16A 5dzk2-6dd6A:
undetectable
5dzkM-6dd6A:
undetectable
5dzkN-6dd6A:
undetectable		 5dzk2-6dd6A:
undetectable
5dzkM-6dd6A:
undetectable
5dzkN-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emz INT PROTEIN

(Enterococcus
faecalis) 		no annotation 4 LEU A 354
ARG A 270
ILE A 367
ILE A 272
 None
 1.35A 5dzk2-6emzA:
undetectable
5dzkM-6emzA:
undetectable
5dzkN-6emzA:
undetectable		 5dzk2-6emzA:
undetectable
5dzkM-6emzA:
undetectable
5dzkN-6emzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emz INT PROTEIN

(Enterococcus
faecalis) 		no annotation 4 LEU A 364
ARG A 270
ILE A 367
ILE A 272
 None
 1.35A 5dzk2-6emzA:
undetectable
5dzkM-6emzA:
undetectable
5dzkN-6emzA:
undetectable		 5dzk2-6emzA:
undetectable
5dzkM-6emzA:
undetectable
5dzkN-6emzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 4 LEU D 481
ARG D 382
ILE D 479
ILE D 386
 None
EDO  D 704 ( 4.7A)
None
None
 1.19A 5dzk2-6eq8D:
undetectable
5dzkM-6eq8D:
undetectable
5dzkN-6eq8D:
undetectable		 5dzk2-6eq8D:
undetectable
5dzkM-6eq8D:
undetectable
5dzkN-6eq8D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 LEU A 772
ARG A 781
ILE A 779
ILE A 761
 None
 1.40A 5dzk2-6fikA:
undetectable
5dzkM-6fikA:
undetectable
5dzkN-6fikA:
undetectable		 5dzk2-6fikA:
undetectable
5dzkM-6fikA:
undetectable
5dzkN-6fikA:
undetectable