SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZK_1_BEZ1801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdo ACETYL-COA
CARBOXYLASE

(Escherichia
coli) 		PF00364
(Biotin_lipoyl) 		3 LEU A 139
PHE A  91
ILE A 138
 None
 0.77A 5dzk1-1bdoA:
undetectable
5dzkF-1bdoA:
0.0
5dzkM-1bdoA:
0.0		 5dzk1-1bdoA:
3.17
5dzkF-1bdoA:
14.76
5dzkM-1bdoA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN

(Caenorhabditis
elegans) 		PF00795
(CN_hydrolase)
PF01230
(HIT) 		3 LEU A 333
PHE A 312
ILE A 395
 None
 0.73A 5dzk1-1emsA:
undetectable
5dzkF-1emsA:
2.4
5dzkM-1emsA:
0.0		 5dzk1-1emsA:
7.14
5dzkF-1emsA:
20.87
5dzkM-1emsA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 LEU A  86
PHE A 452
ILE A  98
 None
 0.68A 5dzk1-1gpeA:
undetectable
5dzkF-1gpeA:
3.0
5dzkM-1gpeA:
0.0		 5dzk1-1gpeA:
15.38
5dzkF-1gpeA:
17.60
5dzkM-1gpeA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iou YKT6P

(Saccharomyces
cerevisiae) 		PF13774
(Longin) 		3 LEU A  79
PHE A   9
ILE A  80
 None
 0.74A 5dzk1-1iouA:
undetectable
5dzkF-1iouA:
undetectable
5dzkM-1iouA:
0.0		 5dzk1-1iouA:
2.13
5dzkF-1iouA:
20.00
5dzkM-1iouA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		3 LEU A 151
PHE A 120
ILE A 148
 None
 0.72A 5dzk1-1iuqA:
undetectable
5dzkF-1iuqA:
0.0
5dzkM-1iuqA:
0.0		 5dzk1-1iuqA:
11.76
5dzkF-1iuqA:
20.16
5dzkM-1iuqA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmk SURFACTIN SYNTHETASE

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		3 LEU C  64
PHE C  24
ILE C  65
 None
 0.76A 5dzk1-1jmkC:
undetectable
5dzkF-1jmkC:
1.5
5dzkM-1jmkC:
0.1		 5dzk1-1jmkC:
1.15
5dzkF-1jmkC:
22.92
5dzkM-1jmkC:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmo HEPARIN COFACTOR II

(Homo sapiens) 		PF00079
(Serpin) 		3 LEU A 417
PHE A 399
ILE A 270
 None
 0.75A 5dzk1-1jmoA:
undetectable
5dzkF-1jmoA:
0.0
5dzkM-1jmoA:
0.0		 5dzk1-1jmoA:
5.56
5dzkF-1jmoA:
15.93
5dzkM-1jmoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		3 LEU A 213
PHE A 219
ILE A  22
 None
 0.66A 5dzk1-1m3uA:
undetectable
5dzkF-1m3uA:
0.9
5dzkM-1m3uA:
0.0		 5dzk1-1m3uA:
22.22
5dzkF-1m3uA:
21.71
5dzkM-1m3uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0e PROTEIN MRAZ

(Mycoplasma
pneumoniae) 		PF02381
(MraZ) 		3 LEU A  96
PHE A  61
ILE A  97
 None
 0.71A 5dzk1-1n0eA:
undetectable
5dzkF-1n0eA:
0.0
5dzkM-1n0eA:
0.0		 5dzk1-1n0eA:
7.14
5dzkF-1n0eA:
26.43
5dzkM-1n0eA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2

(Mus musculus) 		PF09258
(Glyco_transf_64) 		3 LEU A 148
PHE A 219
ILE A  70
 None
 0.73A 5dzk1-1omxA:
undetectable
5dzkF-1omxA:
undetectable
5dzkM-1omxA:
undetectable		 5dzk1-1omxA:
50.00
5dzkF-1omxA:
19.73
5dzkM-1omxA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		3 LEU A 274
PHE A 159
ILE A 273
 None
 0.68A 5dzk1-1osnA:
undetectable
5dzkF-1osnA:
undetectable
5dzkM-1osnA:
undetectable		 5dzk1-1osnA:
4.44
5dzkF-1osnA:
20.63
5dzkM-1osnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5t CYTIDINE DEAMINASE

(Saccharomyces
cerevisiae) 		PF00383
(dCMP_cyt_deam_1) 		3 LEU A  39
PHE A 111
ILE A  38
 None
 0.68A 5dzk1-1r5tA:
undetectable
5dzkF-1r5tA:
undetectable
5dzkM-1r5tA:
undetectable		 5dzk1-1r5tA:
1.52
5dzkF-1r5tA:
20.89
5dzkM-1r5tA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcd L FERRITIN

(Rana
catesbeiana) 		PF00210
(Ferritin) 		3 LEU A  65
PHE A  24
ILE A  66
 None
 0.71A 5dzk1-1rcdA:
undetectable
5dzkF-1rcdA:
undetectable
5dzkM-1rcdA:
undetectable		 5dzk1-1rcdA:
1.79
5dzkF-1rcdA:
23.18
5dzkM-1rcdA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF07732
(Cu-oxidase_3) 		3 LEU A 158
PHE A 190
ILE A 159
 None
 0.73A 5dzk1-1sddA:
undetectable
5dzkF-1sddA:
undetectable
5dzkM-1sddA:
undetectable		 5dzk1-1sddA:
3.45
5dzkF-1sddA:
20.32
5dzkM-1sddA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spi FRUCTOSE
1,6-BISPHOSPHATASE

(Spinacia
oleracea) 		PF00316
(FBPase) 		3 LEU A 186
PHE A 312
ILE A 203
 None
 0.74A 5dzk1-1spiA:
undetectable
5dzkF-1spiA:
undetectable
5dzkM-1spiA:
undetectable		 5dzk1-1spiA:
7.14
5dzkF-1spiA:
20.39
5dzkM-1spiA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
SMALL SUBUNIT

(Rhodococcus
jostii) 		PF00866
(Ring_hydroxyl_B) 		3 LEU B 172
PHE B 133
ILE B 173
 None
 0.64A 5dzk1-1uliB:
undetectable
5dzkF-1uliB:
undetectable
5dzkM-1uliB:
undetectable		 5dzk1-1uliB:
5.41
5dzkF-1uliB:
24.22
5dzkM-1uliB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkp FLOWERING LOCUS T
PROTEIN

(Arabidopsis
thaliana) 		PF01161
(PBP) 		3 LEU A 124
PHE A  22
ILE A 123
 None
 0.74A 5dzk1-1wkpA:
undetectable
5dzkF-1wkpA:
undetectable
5dzkM-1wkpA:
undetectable		 5dzk1-1wkpA:
4.35
5dzkF-1wkpA:
21.27
5dzkM-1wkpA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		3 LEU A 385
PHE A 261
ILE A 386
 None
 0.73A 5dzk1-1x9sA:
undetectable
5dzkF-1x9sA:
undetectable
5dzkM-1x9sA:
undetectable		 5dzk1-1x9sA:
16.67
5dzkF-1x9sA:
15.71
5dzkM-1x9sA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		3 LEU A 120
PHE A 216
ILE A 128
 None
 0.73A 5dzk1-1z0uA:
undetectable
5dzkF-1z0uA:
undetectable
5dzkM-1z0uA:
undetectable		 5dzk1-1z0uA:
1.90
5dzkF-1z0uA:
21.80
5dzkM-1z0uA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z47 PUTATIVE
ABC-TRANSPORTER
ATP-BINDING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 LEU A  60
PHE A  36
ILE A  61
 None
 0.73A 5dzk1-1z47A:
undetectable
5dzkF-1z47A:
undetectable
5dzkM-1z47A:
undetectable		 5dzk1-1z47A:
4.26
5dzkF-1z47A:
21.74
5dzkM-1z47A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6u NP95-LIKE RING
FINGER PROTEIN
ISOFORM B

(Homo sapiens) 		PF00097
(zf-C3HC4) 		3 LEU A 699
PHE A 794
ILE A 700
 None
 0.68A 5dzk1-1z6uA:
undetectable
5dzkF-1z6uA:
undetectable
5dzkM-1z6uA:
undetectable		 5dzk1-1z6uA:
1.44
5dzkF-1z6uA:
20.89
5dzkM-1z6uA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Streptococcus
pneumoniae) 		PF01048
(PNP_UDP_1) 		3 LEU A  71
PHE A 125
ILE A   3
 None
 0.66A 5dzk1-1zosA:
undetectable
5dzkF-1zosA:
undetectable
5dzkM-1zosA:
undetectable		 5dzk1-1zosA:
0.90
5dzkF-1zosA:
24.71
5dzkM-1zosA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asn NITROPHORIN 2

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		3 LEU X  55
PHE X 176
ILE X  69
 HEM  X 201 (-4.1A)
None
None
 0.63A 5dzk1-2asnX:
undetectable
5dzkF-2asnX:
undetectable
5dzkM-2asnX:
undetectable		 5dzk1-2asnX:
1.12
5dzkF-2asnX:
21.13
5dzkM-2asnX:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0n A197

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 3 LEU A 188
PHE A 173
ILE A 187
 None
 0.72A 5dzk1-2c0nA:
undetectable
5dzkF-2c0nA:
undetectable
5dzkM-2c0nA:
undetectable		 5dzk1-2c0nA:
2.20
5dzkF-2c0nA:
23.11
5dzkM-2c0nA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2div TRNA SELENOCYSTEINE
ASSOCIATED PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		3 LEU A  69
PHE A  59
ILE A  72
 None
 0.74A 5dzk1-2divA:
undetectable
5dzkF-2divA:
undetectable
5dzkM-2divA:
undetectable		 5dzk1-2divA:
11.76
5dzkF-2divA:
17.89
5dzkM-2divA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e66 DIVALENT-CATION
TOLERANCE PROTEIN
CUTA

(Pyrococcus
horikoshii) 		PF03091
(CutA1) 		3 LEU A  72
PHE A   8
ILE A  69
 None
 0.54A 5dzk1-2e66A:
undetectable
5dzkF-2e66A:
undetectable
5dzkM-2e66A:
undetectable		 5dzk1-2e66A:
9.09
5dzkF-2e66A:
17.21
5dzkM-2e66A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE

(Desulfovibrio
gigas) 		no annotation 3 LEU L 318
PHE L 314
ILE L 319
 None
 0.73A 5dzk1-2frvL:
undetectable
5dzkF-2frvL:
undetectable
5dzkM-2frvL:
undetectable		 5dzk1-2frvL:
0.76
5dzkF-2frvL:
17.20
5dzkM-2frvL:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		3 LEU A 109
PHE A  71
ILE A 108
 None
 0.77A 5dzk1-2guhA:
undetectable
5dzkF-2guhA:
undetectable
5dzkM-2guhA:
undetectable		 5dzk1-2guhA:
0.95
5dzkF-2guhA:
24.69
5dzkM-2guhA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hje AUTOINDUCER 2 SENSOR
KINASE/PHOSPHATASE
LUXQ

(Vibrio harveyi) 		PF09308
(LuxQ-periplasm) 		3 LEU A 224
PHE A 196
ILE A 225
 None
 0.67A 5dzk1-2hjeA:
undetectable
5dzkF-2hjeA:
undetectable
5dzkM-2hjeA:
undetectable		 5dzk1-2hjeA:
0.92
5dzkF-2hjeA:
25.00
5dzkM-2hjeA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihc TRANSCRIPTION
REGULATOR PROTEIN
BACH1

(Homo sapiens) 		PF00651
(BTB) 		3 LEU A  87
PHE A  59
ILE A  88
 None
 0.71A 5dzk1-2ihcA:
undetectable
5dzkF-2ihcA:
undetectable
5dzkM-2ihcA:
undetectable		 5dzk1-2ihcA:
11.11
5dzkF-2ihcA:
19.47
5dzkM-2ihcA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		3 LEU A 252
PHE A 226
ILE A 273
 None
 0.76A 5dzk1-2p4zA:
undetectable
5dzkF-2p4zA:
undetectable
5dzkM-2p4zA:
undetectable		 5dzk1-2p4zA:
5.41
5dzkF-2p4zA:
21.48
5dzkM-2p4zA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pd3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Helicobacter
pylori) 		PF13561
(adh_short_C2) 		3 LEU A  10
PHE A  87
ILE A  11
 None
 0.72A 5dzk1-2pd3A:
undetectable
5dzkF-2pd3A:
undetectable
5dzkM-2pd3A:
undetectable		 5dzk1-2pd3A:
1.90
5dzkF-2pd3A:
22.06
5dzkM-2pd3A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE

(Cryptosporidium
parvum) 		PF00160
(Pro_isomerase) 		3 LEU A 103
PHE A  33
ILE A 102
 None
FMT  A 204 ( 4.4A)
FMT  A 201 (-4.9A)
 0.63A 5dzk1-2poeA:
undetectable
5dzkF-2poeA:
undetectable
5dzkM-2poeA:
undetectable		 5dzk1-2poeA:
0.54
5dzkF-2poeA:
21.96
5dzkM-2poeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		3 LEU A 462
PHE A 489
ILE A 453
 None
 0.70A 5dzk1-2pyjA:
undetectable
5dzkF-2pyjA:
undetectable
5dzkM-2pyjA:
undetectable		 5dzk1-2pyjA:
1.12
5dzkF-2pyjA:
15.97
5dzkM-2pyjA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35

(Homo sapiens) 		PF03635
(Vps35) 		3 LEU C 571
PHE C 584
ILE C 572
 None
 0.66A 5dzk1-2r17C:
undetectable
5dzkF-2r17C:
undetectable
5dzkM-2r17C:
undetectable		 5dzk1-2r17C:
12.50
5dzkF-2r17C:
23.10
5dzkM-2r17C:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rij PUTATIVE
2,3,4,5-TETRAHYDROPY
RIDINE-2-CARBOXYLATE
N-
SUCCINYLTRANSFERASE

(Campylobacter
jejuni) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		3 LEU A 321
PHE A 326
ILE A 306
 None
 0.75A 5dzk1-2rijA:
undetectable
5dzkF-2rijA:
undetectable
5dzkM-2rijA:
undetectable		 5dzk1-2rijA:
18.18
5dzkF-2rijA:
20.31
5dzkM-2rijA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyw HEMOGLOBIN

(Fasciola
hepatica) 		PF00042
(Globin) 		3 LEU A  78
PHE A 120
ILE A  76
 None
 0.70A 5dzk1-2vywA:
undetectable
5dzkF-2vywA:
undetectable
5dzkM-2vywA:
undetectable		 5dzk1-2vywA:
2.53
5dzkF-2vywA:
20.80
5dzkM-2vywA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A

(Homo sapiens) 		PF00160
(Pro_isomerase) 		3 LEU B  98
PHE B  25
ILE B  97
 None
 0.61A 5dzk1-2x25B:
undetectable
5dzkF-2x25B:
undetectable
5dzkM-2x25B:
undetectable		 5dzk1-2x25B:
0.59
5dzkF-2x25B:
19.81
5dzkM-2x25B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsz RUVB-LIKE 1

(Homo sapiens) 		PF06068
(TIP49) 		3 LEU A 210
PHE A 107
ILE A 239
 None
 0.77A 5dzk1-2xszA:
undetectable
5dzkF-2xszA:
2.2
5dzkM-2xszA:
undetectable		 5dzk1-2xszA:
20.00
5dzkF-2xszA:
20.00
5dzkM-2xszA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		3 LEU B 981
PHE B1015
ILE B 982
 None
 0.77A 5dzk1-2xwbB:
undetectable
5dzkF-2xwbB:
undetectable
5dzkM-2xwbB:
undetectable		 5dzk1-2xwbB:
1.72
5dzkF-2xwbB:
14.34
5dzkM-2xwbB:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		3 LEU A 180
PHE A 192
ILE A 181
 None
 0.68A 5dzk1-3c6cA:
undetectable
5dzkF-3c6cA:
4.3
5dzkM-3c6cA:
undetectable		 5dzk1-3c6cA:
1.80
5dzkF-3c6cA:
20.19
5dzkM-3c6cA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 LEU A 753
PHE A 854
ILE A 994
 None
 0.74A 5dzk1-3decA:
undetectable
5dzkF-3decA:
2.8
5dzkM-3decA:
1.6		 5dzk1-3decA:
13.33
5dzkF-3decA:
12.87
5dzkM-3decA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5d PUTATIVE GLYOXALASE
I

(Listeria
monocytogenes) 		PF00903
(Glyoxalase) 		3 LEU A 115
PHE A  19
ILE A 122
 None
 0.77A 5dzk1-3e5dA:
undetectable
5dzkF-3e5dA:
undetectable
5dzkM-3e5dA:
undetectable		 5dzk1-3e5dA:
14.29
5dzkF-3e5dA:
21.03
5dzkM-3e5dA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas
putida) 		PF00866
(Ring_hydroxyl_B) 		3 LEU B 172
PHE B 133
ILE B 173
 None
 0.66A 5dzk1-3eqqB:
undetectable
5dzkF-3eqqB:
undetectable
5dzkM-3eqqB:
undetectable		 5dzk1-3eqqB:
5.41
5dzkF-3eqqB:
23.32
5dzkM-3eqqB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LEU A   4
PHE A  32
ILE A 267
 None
 0.72A 5dzk1-3etcA:
undetectable
5dzkF-3etcA:
undetectable
5dzkM-3etcA:
undetectable		 5dzk1-3etcA:
7.14
5dzkF-3etcA:
18.32
5dzkM-3etcA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flj UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA WITH A
CYSTATIN-LIKE FOLD

(Ruegeria
pomeroyi) 		PF12680
(SnoaL_2) 		3 LEU A  23
PHE A 101
ILE A  20
 None
 0.76A 5dzk1-3fljA:
undetectable
5dzkF-3fljA:
undetectable
5dzkM-3fljA:
undetectable		 5dzk1-3fljA:
4.65
5dzkF-3fljA:
22.75
5dzkM-3fljA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g40 NA-K-CL
COTRANSPORTER

(Methanosarcina
acetivorans) 		no annotation 3 LEU A 616
PHE A 587
ILE A 746
 None
 0.67A 5dzk1-3g40A:
undetectable
5dzkF-3g40A:
undetectable
5dzkM-3g40A:
undetectable		 5dzk1-3g40A:
8.33
5dzkF-3g40A:
21.62
5dzkM-3g40A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LEU A 147
PHE A 218
ILE A 148
 None
 0.74A 5dzk1-3glqA:
undetectable
5dzkF-3glqA:
undetectable
5dzkM-3glqA:
undetectable		 5dzk1-3glqA:
1.20
5dzkF-3glqA:
19.42
5dzkM-3glqA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		3 LEU A 152
PHE A 118
ILE A 153
 None
 0.73A 5dzk1-3gs9A:
undetectable
5dzkF-3gs9A:
undetectable
5dzkM-3gs9A:
undetectable		 5dzk1-3gs9A:
1.27
5dzkF-3gs9A:
21.70
5dzkM-3gs9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		3 LEU A  76
PHE A   6
ILE A  77
 None
 0.73A 5dzk1-3h2zA:
undetectable
5dzkF-3h2zA:
undetectable
5dzkM-3h2zA:
undetectable		 5dzk1-3h2zA:
10.00
5dzkF-3h2zA:
21.00
5dzkM-3h2zA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihk THIAMIN
PYROPHOSPHOKINASE

(Streptococcus
mutans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 LEU A 132
PHE A  98
ILE A 204
 None
 0.74A 5dzk1-3ihkA:
undetectable
5dzkF-3ihkA:
undetectable
5dzkM-3ihkA:
undetectable		 5dzk1-3ihkA:
6.06
5dzkF-3ihkA:
20.00
5dzkM-3ihkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens) 		PF00400
(WD40) 		3 LEU A 163
PHE A 198
ILE A 174
 None
 0.77A 5dzk1-3iiwA:
undetectable
5dzkF-3iiwA:
undetectable
5dzkM-3iiwA:
undetectable		 5dzk1-3iiwA:
3.39
5dzkF-3iiwA:
22.50
5dzkM-3iiwA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		3 LEU A 267
PHE A 440
ILE A 301
 None
 0.56A 5dzk1-3iwjA:
undetectable
5dzkF-3iwjA:
undetectable
5dzkM-3iwjA:
undetectable		 5dzk1-3iwjA:
0.40
5dzkF-3iwjA:
19.37
5dzkM-3iwjA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		3 LEU A 111
PHE A 131
ILE A 112
 None
 0.71A 5dzk1-3k11A:
undetectable
5dzkF-3k11A:
undetectable
5dzkM-3k11A:
undetectable		 5dzk1-3k11A:
12.50
5dzkF-3k11A:
20.18
5dzkM-3k11A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lft UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF04392
(ABC_sub_bind) 		3 LEU A  56
PHE A  89
ILE A 117
 None
 0.72A 5dzk1-3lftA:
undetectable
5dzkF-3lftA:
undetectable
5dzkM-3lftA:
undetectable		 5dzk1-3lftA:
12.50
5dzkF-3lftA:
22.22
5dzkM-3lftA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		3 LEU A 576
PHE A 505
ILE A 575
 None
 0.47A 5dzk1-3mcaA:
undetectable
5dzkF-3mcaA:
undetectable
5dzkM-3mcaA:
undetectable		 5dzk1-3mcaA:
4.35
5dzkF-3mcaA:
15.71
5dzkM-3mcaA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR GADX

(Escherichia
coli) 		PF12833
(HTH_18) 		3 LEU A 201
PHE A 224
ILE A 202
 None
 0.72A 5dzk1-3mklA:
undetectable
5dzkF-3mklA:
undetectable
5dzkM-3mklA:
undetectable		 5dzk1-3mklA:
5.88
5dzkF-3mklA:
19.09
5dzkM-3mklA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3w RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		3 LEU A 138
PHE A  80
ILE A 139
 None
 0.76A 5dzk1-3n3wA:
undetectable
5dzkF-3n3wA:
undetectable
5dzkM-3n3wA:
undetectable		 5dzk1-3n3wA:
0.81
5dzkF-3n3wA:
25.63
5dzkM-3n3wA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		3 LEU A 524
PHE A 489
ILE A 534
 None
 0.72A 5dzk1-3nzqA:
undetectable
5dzkF-3nzqA:
undetectable
5dzkM-3nzqA:
undetectable		 5dzk1-3nzqA:
0.74
5dzkF-3nzqA:
16.38
5dzkM-3nzqA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o60 LIN0861 PROTEIN

(Listeria
innocua) 		no annotation 3 LEU A 156
PHE A 108
ILE A 153
 None
 0.68A 5dzk1-3o60A:
undetectable
5dzkF-3o60A:
undetectable
5dzkM-3o60A:
undetectable		 5dzk1-3o60A:
1.87
5dzkF-3o60A:
23.35
5dzkM-3o60A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		3 LEU A 279
PHE A 264
ILE A 278
 None
 0.72A 5dzk1-3omnA:
undetectable
5dzkF-3omnA:
undetectable
5dzkM-3omnA:
1.1		 5dzk1-3omnA:
0.89
5dzkF-3omnA:
16.60
5dzkM-3omnA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oon OUTER MEMBRANE
PROTEIN (TPN50)

(Borreliella
burgdorferi) 		PF00691
(OmpA) 		3 LEU A 346
PHE A 359
ILE A 347
 None
 0.75A 5dzk1-3oonA:
undetectable
5dzkF-3oonA:
undetectable
5dzkM-3oonA:
undetectable		 5dzk1-3oonA:
4.65
5dzkF-3oonA:
23.61
5dzkM-3oonA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb0 DIHYDRODIPICOLINATE
SYNTHASE

(Thermotoga
maritima) 		PF00701
(DHDPS) 		3 LEU A  38
PHE A   2
ILE A  39
 None
 0.68A 5dzk1-3pb0A:
undetectable
5dzkF-3pb0A:
3.4
5dzkM-3pb0A:
2.6		 5dzk1-3pb0A:
0.67
5dzkF-3pb0A:
22.95
5dzkM-3pb0A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q20 RBCX PROTEIN

(Thermosynechococcus
elongatus) 		PF02341
(RcbX) 		3 LEU A  67
PHE A  61
ILE A  71
 None
 0.77A 5dzk1-3q20A:
undetectable
5dzkF-3q20A:
2.6
5dzkM-3q20A:
undetectable		 5dzk1-3q20A:
11.11
5dzkF-3q20A:
21.15
5dzkM-3q20A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txv PROBABLE TAGATOSE
6-PHOSPHATE KINASE

(Sinorhizobium
meliloti) 		PF08013
(Tagatose_6_P_K) 		3 LEU A  49
PHE A 423
ILE A  26
 None
 0.70A 5dzk1-3txvA:
undetectable
5dzkF-3txvA:
undetectable
5dzkM-3txvA:
undetectable		 5dzk1-3txvA:
2.20
5dzkF-3txvA:
19.38
5dzkM-3txvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyt HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN L

(Mus musculus) 		PF13893
(RRM_5) 		3 LEU A 402
PHE A 482
ILE A 493
 None
 0.77A 5dzk1-3tytA:
undetectable
5dzkF-3tytA:
undetectable
5dzkM-3tytA:
undetectable		 5dzk1-3tytA:
1.18
5dzkF-3tytA:
20.80
5dzkM-3tytA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v70 GTPASE IMAP FAMILY
MEMBER 1

(Homo sapiens) 		PF04548
(AIG1) 		3 LEU A  32
PHE A  87
ILE A  31
 None
 0.73A 5dzk1-3v70A:
undetectable
5dzkF-3v70A:
undetectable
5dzkM-3v70A:
undetectable		 5dzk1-3v70A:
1.98
5dzkF-3v70A:
19.37
5dzkM-3v70A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 LEU A 116
PHE A 140
ILE A 113
 None
 0.60A 5dzk1-3wwzA:
undetectable
5dzkF-3wwzA:
undetectable
5dzkM-3wwzA:
undetectable		 5dzk1-3wwzA:
1.07
5dzkF-3wwzA:
22.25
5dzkM-3wwzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh2 L-LACTATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LEU A 189
PHE A 218
ILE A 193
 None
 0.77A 5dzk1-3zh2A:
undetectable
5dzkF-3zh2A:
undetectable
5dzkM-3zh2A:
undetectable		 5dzk1-3zh2A:
2.02
5dzkF-3zh2A:
22.19
5dzkM-3zh2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		3 LEU A 307
PHE A 312
ILE A 261
 None
 0.66A 5dzk1-4aioA:
undetectable
5dzkF-4aioA:
2.5
5dzkM-4aioA:
undetectable		 5dzk1-4aioA:
0.65
5dzkF-4aioA:
14.02
5dzkM-4aioA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		3 LEU A 294
PHE A 363
ILE A 222
 None
 0.77A 5dzk1-4b3kA:
undetectable
5dzkF-4b3kA:
1.7
5dzkM-4b3kA:
1.1		 5dzk1-4b3kA:
3.12
5dzkF-4b3kA:
18.35
5dzkM-4b3kA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1r MANNOSYL-6-PHOSPHATA
SE

(Bacteroides
thetaiotaomicron) 		PF03372
(Exo_endo_phos) 		3 LEU A 195
PHE A 158
ILE A 250
 None
 0.76A 5dzk1-4c1rA:
undetectable
5dzkF-4c1rA:
undetectable
5dzkM-4c1rA:
undetectable		 5dzk1-4c1rA:
22.22
5dzkF-4c1rA:
21.93
5dzkM-4c1rA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxj KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF00651
(BTB) 		3 LEU A 136
PHE A 107
ILE A 137
 None
 0.75A 5dzk1-4cxjA:
undetectable
5dzkF-4cxjA:
undetectable
5dzkM-4cxjA:
undetectable		 5dzk1-4cxjA:
0.73
5dzkF-4cxjA:
19.07
5dzkM-4cxjA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4g APNAA1

(Planktothrix
agardhii) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LEU A 453
PHE A 487
ILE A 483
 None
 0.70A 5dzk1-4d4gA:
undetectable
5dzkF-4d4gA:
undetectable
5dzkM-4d4gA:
undetectable		 5dzk1-4d4gA:
2.04
5dzkF-4d4gA:
18.40
5dzkM-4d4gA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drf METHYLTRANSFERASE
TYPE 12

(Ruminiclostridium
thermocellum) 		PF12623
(Hen1_L) 		3 LEU B  52
PHE B  39
ILE B   2
 None
 0.75A 5dzk1-4drfB:
undetectable
5dzkF-4drfB:
undetectable
5dzkM-4drfB:
undetectable		 5dzk1-4drfB:
10.53
5dzkF-4drfB:
22.45
5dzkM-4drfB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE

(Mycobacterium
avium) 		PF04909
(Amidohydro_2) 		3 LEU A 351
PHE A 368
ILE A 350
 None
 0.65A 5dzk1-4dziA:
undetectable
5dzkF-4dziA:
1.7
5dzkM-4dziA:
undetectable		 5dzk1-4dziA:
2.70
5dzkF-4dziA:
19.62
5dzkM-4dziA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e10 PROTELOMERASE

(Agrobacterium
fabrum) 		PF16684
(Telomere_res) 		3 LEU A 248
PHE A 260
ILE A 249
 None
 0.73A 5dzk1-4e10A:
undetectable
5dzkF-4e10A:
undetectable
5dzkM-4e10A:
undetectable		 5dzk1-4e10A:
1.32
5dzkF-4e10A:
20.00
5dzkM-4e10A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 LEU A1122
PHE A1194
ILE A1123
 None
 0.73A 5dzk1-4e9xA:
undetectable
5dzkF-4e9xA:
undetectable
5dzkM-4e9xA:
undetectable		 5dzk1-4e9xA:
5.56
5dzkF-4e9xA:
20.83
5dzkM-4e9xA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus) 		PF01979
(Amidohydro_1) 		3 LEU A 272
PHE A 313
ILE A 292
 None
 0.75A 5dzk1-4f0lA:
undetectable
5dzkF-4f0lA:
1.6
5dzkM-4f0lA:
undetectable		 5dzk1-4f0lA:
9.52
5dzkF-4f0lA:
20.04
5dzkM-4f0lA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl0 LMO0810 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		3 LEU A  50
PHE A 281
ILE A  46
 None
 0.66A 5dzk1-4gl0A:
undetectable
5dzkF-4gl0A:
undetectable
5dzkM-4gl0A:
undetectable		 5dzk1-4gl0A:
2.53
5dzkF-4gl0A:
22.52
5dzkM-4gl0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr7 BIOTIN CARBOXYL
CARRIER PROTEIN OF
ACETYL-COA
CARBOXYLASE

(Escherichia
coli) 		PF00364
(Biotin_lipoyl) 		3 LEU B 139
PHE B  91
ILE B 138
 None
 0.77A 5dzk1-4hr7B:
undetectable
5dzkF-4hr7B:
undetectable
5dzkM-4hr7B:
undetectable		 5dzk1-4hr7B:
6.90
5dzkF-4hr7B:
24.23
5dzkM-4hr7B:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxi KELCH-LIKE PROTEIN 3

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		3 LEU A 104
PHE A  75
ILE A 105
 None
 0.74A 5dzk1-4hxiA:
undetectable
5dzkF-4hxiA:
undetectable
5dzkM-4hxiA:
undetectable		 5dzk1-4hxiA:
1.18
5dzkF-4hxiA:
22.49
5dzkM-4hxiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1a RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE I

(Bacillus
subtilis) 		PF13424
(TPR_12) 		3 LEU A 194
PHE A 207
ILE A 195
 None
 0.68A 5dzk1-4i1aA:
undetectable
5dzkF-4i1aA:
undetectable
5dzkM-4i1aA:
undetectable		 5dzk1-4i1aA:
4.26
5dzkF-4i1aA:
20.30
5dzkM-4i1aA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		3 LEU A 415
PHE A 373
ILE A 413
 None
 0.77A 5dzk1-4j5uA:
undetectable
5dzkF-4j5uA:
undetectable
5dzkM-4j5uA:
undetectable		 5dzk1-4j5uA:
3.92
5dzkF-4j5uA:
21.34
5dzkM-4j5uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		3 LEU A 528
PHE A 608
ILE A 526
 None
 0.75A 5dzk1-4jc8A:
undetectable
5dzkF-4jc8A:
undetectable
5dzkM-4jc8A:
undetectable		 5dzk1-4jc8A:
8.70
5dzkF-4jc8A:
14.71
5dzkM-4jc8A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgp SPORULATION KINASE D

(Bacillus
subtilis) 		PF02743
(dCache_1) 		3 LEU A 188
PHE A 209
ILE A  62
 None
 0.73A 5dzk1-4jgpA:
undetectable
5dzkF-4jgpA:
undetectable
5dzkM-4jgpA:
undetectable		 5dzk1-4jgpA:
9.09
5dzkF-4jgpA:
20.65
5dzkM-4jgpA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Citrus sinensis) 		PF00160
(Pro_isomerase) 		3 LEU A 105
PHE A  25
ILE A 104
 None
 0.66A 5dzk1-4jjmA:
undetectable
5dzkF-4jjmA:
undetectable
5dzkM-4jjmA:
undetectable		 5dzk1-4jjmA:
0.57
5dzkF-4jjmA:
20.41
5dzkM-4jjmA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		3 LEU A 337
PHE A 120
ILE A 336
 None
 0.72A 5dzk1-4kdsA:
undetectable
5dzkF-4kdsA:
undetectable
5dzkM-4kdsA:
undetectable		 5dzk1-4kdsA:
2.35
5dzkF-4kdsA:
20.92
5dzkM-4kdsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8o BILE ACID
7A-DEHYDRATASE, BAIE

([Clostridium]
hylemonae) 		PF13577
(SnoaL_4) 		3 LEU A 108
PHE A 153
ILE A 109
 None
 0.68A 5dzk1-4l8oA:
undetectable
5dzkF-4l8oA:
undetectable
5dzkM-4l8oA:
undetectable		 5dzk1-4l8oA:
3.08
5dzkF-4l8oA:
20.76
5dzkM-4l8oA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8p BILE ACID
7A-DEHYDRATASE, BAIE

([Clostridium]
hiranonis) 		PF13577
(SnoaL_4) 		3 LEU A 108
PHE A 152
ILE A 109
 None
 0.67A 5dzk1-4l8pA:
undetectable
5dzkF-4l8pA:
undetectable
5dzkM-4l8pA:
undetectable		 5dzk1-4l8pA:
3.08
5dzkF-4l8pA:
22.51
5dzkM-4l8pA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leh BILE ACID 7-ALPHA
DEHYDRATASE, BAIE

([Clostridium]
scindens) 		PF13577
(SnoaL_4) 		3 LEU A 111
PHE A 155
ILE A 112
 None
 0.69A 5dzk1-4lehA:
undetectable
5dzkF-4lehA:
undetectable
5dzkM-4lehA:
undetectable		 5dzk1-4lehA:
3.28
5dzkF-4lehA:
19.82
5dzkM-4lehA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		3 LEU A 286
PHE A 273
ILE A 312
 None
 0.76A 5dzk1-4m46A:
undetectable
5dzkF-4m46A:
undetectable
5dzkM-4m46A:
undetectable		 5dzk1-4m46A:
0.34
5dzkF-4m46A:
17.90
5dzkM-4m46A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 LEU A 215
PHE A 131
ILE A 216
 None
 0.69A 5dzk1-4o5hA:
undetectable
5dzkF-4o5hA:
2.9
5dzkM-4o5hA:
undetectable		 5dzk1-4o5hA:
10.00
5dzkF-4o5hA:
17.73
5dzkM-4o5hA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		3 LEU A 287
PHE A 298
ILE A 223
 None
 0.73A 5dzk1-4oanA:
undetectable
5dzkF-4oanA:
undetectable
5dzkM-4oanA:
undetectable		 5dzk1-4oanA:
0.62
5dzkF-4oanA:
22.32
5dzkM-4oanA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oaq R-SPECIFIC CARBONYL
REDUCTASE

(Candida
parapsilosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LEU A  40
PHE A   9
ILE A  78
 None
 0.65A 5dzk1-4oaqA:
undetectable
5dzkF-4oaqA:
undetectable
5dzkM-4oaqA:
undetectable		 5dzk1-4oaqA:
0.65
5dzkF-4oaqA:
19.73
5dzkM-4oaqA:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C) 		3 LEU A 160
PHE A 198
ILE A 161
 None
 0.71A 5dzk1-4whoA:
undetectable
5dzkF-4whoA:
undetectable
5dzkM-4whoA:
undetectable		 5dzk1-4whoA:
40.00
5dzkF-4whoA:
24.44
5dzkM-4whoA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		3 LEU C 911
PHE C 441
ILE C 910
 None
 0.74A 5dzk1-5exrC:
undetectable
5dzkF-5exrC:
undetectable
5dzkM-5exrC:
undetectable		 5dzk1-5exrC:
1.16
5dzkF-5exrC:
12.36
5dzkM-5exrC:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		3 LEU D 420
PHE D 455
ILE D 410
 None
 0.73A 5dzk1-5exrD:
undetectable
5dzkF-5exrD:
1.9
5dzkM-5exrD:
undetectable		 5dzk1-5exrD:
1.83
5dzkF-5exrD:
16.44
5dzkM-5exrD:
15.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN

(Saccharomyces
cerevisiae) 		no annotation 3 LEU A  72
PHE A  87
ILE A  73
 None
 0.65A 5dzk1-5fg0A:
undetectable
5dzkF-5fg0A:
undetectable
5dzkM-5fg0A:
undetectable		 5dzk1-5fg0A:
33.33
5dzkF-5fg0A:
17.15
5dzkM-5fg0A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		3 LEU A1311
PHE A1374
ILE A1331
 None
 0.69A 5dzk1-5fv0A:
undetectable
5dzkF-5fv0A:
undetectable
5dzkM-5fv0A:
undetectable		 5dzk1-5fv0A:
3.77
5dzkF-5fv0A:
16.54
5dzkM-5fv0A:
17.58