SIMILAR PATTERNS OF AMINO ACIDS FOR 5DZ2_B_212B404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1yyr	TRICHODIENE SYNTHASE (Fusarium sporotrichioides)	PF06330 (TRI5)	5	ARG A 182 ASN A 225 SER A 229 GLU A 233 ARG A 304	SAZ A 709 ( 3.8A) SAZ A 709 (-3.3A) None None SAZ A 709 ( 4.5A)	1.03A	5dz2B-1yyrA: 20.1	5dz2B-1yyrA: 21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lg5	EPI-ISOZIZAENE SYNTHASE (Streptomyces coelicolor)	no annotation	7	ASP A 99 ARG A 194 ASN A 240 SER A 244 GLU A 248 ARG A 338 TYR A 339	MG A 701 (-2.5A) POP A 703 (-2.8A) MG A 702 (-2.6A) MG A 702 ( 2.3A) MG A 702 ( 2.6A) POP A 703 (-4.0A) POP A 703 ( 4.4A)	0.67A	5dz2B-3lg5A: 35.9	5dz2B-3lg5A: 24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3v1v	2-METHYLISOBORNEOL SYNTHASE (Streptomyces coelicolor)	no annotation	6	ARG A 300 ASN A 345 SER A 349 GLU A 353 ARG A 433 TYR A 434	GST A 511 (-3.4A) MG A 501 ( 2.7A) MG A 501 ( 2.3A) MG A 501 ( 2.6A) GST A 511 (-3.9A) GST A 511 (-4.6A)	0.69A	5dz2B-3v1vA: 32.0	5dz2B-3v1vA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4okm	TERPENE SYNTHASE METAL-BINDING DOMAIN-CONTAINING PROTEIN (Streptomyces pristinaespiralis)	no annotation	7	ASP A 82 ARG A 178 ASN A 224 SER A 228 GLU A 232 ARG A 310 TYR A 311	MG A 902 ( 2.5A) PPV A 904 (-2.9A) MG A 903 ( 2.7A) MG A 903 ( 2.3A) MG A 903 ( 2.7A) PPV A 904 (-3.9A) PPV A 904 (-4.4A)	0.90A	5dz2B-4okmA: 36.0	5dz2B-4okmA: 25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4zq8	ISOPRENOID SYNTHASE (Streptomyces lydicus)	no annotation	6	ARG A 214 ASN A 259 SER A 263 ARG A 266 GLU A 267 TYR A 346	None	0.85A	5dz2B-4zq8A: 31.6	5dz2B-4zq8A: 26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4zq8	ISOPRENOID SYNTHASE (Streptomyces lydicus)	no annotation	5	ASN A 259 SER A 263 GLU A 267 ARG A 345 TYR A 346	None	0.99A	5dz2B-4zq8A: 31.6	5dz2B-4zq8A: 26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5a0k	LABDANE-RELATED DITERPENE SYNTHASE (Streptomyces sp.)	no annotation	6	ARG A 184 ASN A 230 SER A 234 ARG A 237 ARG A 316 TYR A 317	MG A1323 (-4.0A) MG A1323 (-3.5A) MG A1323 (-3.4A) None None None	0.91A	5dz2B-5a0kA: 33.3	5dz2B-5a0kA: 29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5a0k	LABDANE-RELATED DITERPENE SYNTHASE (Streptomyces sp.)	no annotation	5	ASP A 90 ARG A 184 ASN A 230 SER A 234 TYR A 317	MG A1321 (-3.3A) MG A1323 (-4.0A) MG A1323 (-3.5A) MG A1323 (-3.4A) None	1.08A	5dz2B-5a0kA: 33.3	5dz2B-5a0kA: 29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5erm	FUSICOCCADIENE SYNTHASE (Diaporthe amygdali)	no annotation	7	ASP A 92 ARG A 188 ASN A 232 SER A 236 GLU A 240 ARG A 325 TYR A 326	MG A 404 (-2.3A) 210 A 401 ( 2.3A) 210 A 401 ( 2.5A) MG A 405 ( 2.3A) MG A 405 (-2.5A) 210 A 401 (-3.1A) 210 A 401 (-4.5A)	0.71A	5dz2B-5ermA: 23.0	5dz2B-5ermA: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5erm	FUSICOCCADIENE SYNTHASE (Diaporthe amygdali)	no annotation	5	ASP A 96 ARG A 188 ASN A 232 SER A 236 TYR A 326	MG A 403 (-2.4A) 210 A 401 ( 2.3A) 210 A 401 ( 2.5A) MG A 405 ( 2.3A) 210 A 401 (-4.5A)	1.34A	5dz2B-5ermA: 23.0	5dz2B-5ermA: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5in8	ARISTOLOCHENE SYNTHASE (Aspergillus terreus)	no annotation	6	ARG A 169 ASN A 213 SER A 217 GLU A 221 ARG A 308 TYR A 309	MG A 403 ( 4.2A) MG A 403 ( 2.8A) MG A 403 ( 2.4A) MG A 403 ( 2.8A) PO4 A 404 (-3.9A) PO4 A 404 (-4.4A)	0.80A	5dz2B-5in8A: 31.9	5dz2B-5in8A: 23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5nx7	PENTALENENE SYNTHASE (Streptomyces clavuligerus)	no annotation	7	ASP A 81 ARG A 174 ASN A 220 SER A 224 GLU A 228 ARG A 314 TYR A 315	MG A 404 (-2.6A) 0FV A 400 ( 3.0A) 0FV A 400 (-2.7A) MG A 402 (-2.2A) MG A 402 (-2.6A) LA6 A 401 ( 3.8A) 0FV A 400 ( 4.4A)	0.66A	5dz2B-5nx7A: 39.0	5dz2B-5nx7A: 27.97

[["5DZ2_B_212B404_1","1yyr","Fusarium sporotrichioides","TRICHODIENE SYNTHASE","PF06330(TRI5)",5,"ARG A 182;ASN A 225;SER A 229;GLU A 233;ARG A 304","SAZ A 709 ( 3.8A);SAZ A 709 (-3.3A);None;None;SAZ A 709 ( 4.5A)","1.03A","5dz2B-1yyrA:20.1","5dz2B-1yyrA:21.66"],["5DZ2_B_212B404_1","3lg5","Streptomyces coelicolor","EPI-ISOZIZAENE SYNTHASE","no annotation",7,"ASP A  99;ARG A 194;ASN A 240;SER A 244;GLU A 248;ARG A 338;TYR A 339"," MG A 701 (-2.5A);POP A 703 (-2.8A); MG A 702 (-2.6A); MG A 702 ( 2.3A); MG A 702 ( 2.6A);POP A 703 (-4.0A);POP A 703 ( 4.4A)","0.67A","5dz2B-3lg5A:35.9","5dz2B-3lg5A:24.88"],["5DZ2_B_212B404_1","3v1v","Streptomyces coelicolor","2-METHYLISOBORNEOL SYNTHASE","no annotation",6,"ARG A 300;ASN A 345;SER A 349;GLU A 353;ARG A 433;TYR A 434","GST A 511 (-3.4A); MG A 501 ( 2.7A); MG A 501 ( 2.3A); MG A 501 ( 2.6A);GST A 511 (-3.9A);GST A 511 (-4.6A)","0.69A","5dz2B-3v1vA:32.0","5dz2B-3v1vA:22.27"],["5DZ2_B_212B404_1","4okm","Streptomyces pristinaespiralis","TERPENE SYNTHASE METAL-BINDING DOMAIN-CONTAINING PROTEIN","no annotation",7,"ASP A  82;ARG A 178;ASN A 224;SER A 228;GLU A 232;ARG A 310;TYR A 311"," MG A 902 ( 2.5A);PPV A 904 (-2.9A); MG A 903 ( 2.7A); MG A 903 ( 2.3A); MG A 903 ( 2.7A);PPV A 904 (-3.9A);PPV A 904 (-4.4A)","0.90A","5dz2B-4okmA:36.0","5dz2B-4okmA:25.26"],["5DZ2_B_212B404_1","4zq8","Streptomyces lydicus","ISOPRENOID SYNTHASE","no annotation",6,"ARG A 214;ASN A 259;SER A 263;ARG A 266;GLU A 267;TYR A 346","None","0.85A","5dz2B-4zq8A:31.6","5dz2B-4zq8A:26.46"],["5DZ2_B_212B404_1","4zq8","Streptomyces lydicus","ISOPRENOID SYNTHASE","no annotation",5,"ASN A 259;SER A 263;GLU A 267;ARG A 345;TYR A 346","None","0.99A","5dz2B-4zq8A:31.6","5dz2B-4zq8A:26.46"],["5DZ2_B_212B404_1","5a0k","Streptomyces sp.","LABDANE-RELATED DITERPENE SYNTHASE","no annotation",6,"ARG A 184;ASN A 230;SER A 234;ARG A 237;ARG A 316;TYR A 317"," MG A1323 (-4.0A); MG A1323 (-3.5A); MG A1323 (-3.4A);None;None;None","0.91A","5dz2B-5a0kA:33.3","5dz2B-5a0kA:29.97"],["5DZ2_B_212B404_1","5a0k","Streptomyces sp.","LABDANE-RELATED DITERPENE SYNTHASE","no annotation",5,"ASP A  90;ARG A 184;ASN A 230;SER A 234;TYR A 317"," MG A1321 (-3.3A); MG A1323 (-4.0A); MG A1323 (-3.5A); MG A1323 (-3.4A);None","1.08A","5dz2B-5a0kA:33.3","5dz2B-5a0kA:29.97"],["5DZ2_B_212B404_1","5erm","Diaporthe amygdali","FUSICOCCADIENE SYNTHASE","no annotation",7,"ASP A  92;ARG A 188;ASN A 232;SER A 236;GLU A 240;ARG A 325;TYR A 326"," MG A 404 (-2.3A);210 A 401 ( 2.3A);210 A 401 ( 2.5A); MG A 405 ( 2.3A); MG A 405 (-2.5A);210 A 401 (-3.1A);210 A 401 (-4.5A)","0.71A","5dz2B-5ermA:23.0","5dz2B-5ermA:21.71"],["5DZ2_B_212B404_1","5erm","Diaporthe amygdali","FUSICOCCADIENE SYNTHASE","no annotation",5,"ASP A  96;ARG A 188;ASN A 232;SER A 236;TYR A 326"," MG A 403 (-2.4A);210 A 401 ( 2.3A);210 A 401 ( 2.5A); MG A 405 ( 2.3A);210 A 401 (-4.5A)","1.34A","5dz2B-5ermA:23.0","5dz2B-5ermA:21.71"],["5DZ2_B_212B404_1","5in8","Aspergillus terreus","ARISTOLOCHENE SYNTHASE","no annotation",6,"ARG A 169;ASN A 213;SER A 217;GLU A 221;ARG A 308;TYR A 309"," MG A 403 ( 4.2A); MG A 403 ( 2.8A); MG A 403 ( 2.4A); MG A 403 ( 2.8A);PO4 A 404 (-3.9A);PO4 A 404 (-4.4A)","0.80A","5dz2B-5in8A:31.9","5dz2B-5in8A:23.56"],["5DZ2_B_212B404_1","5nx7","Streptomyces clavuligerus","PENTALENENE SYNTHASE","no annotation",7,"ASP A  81;ARG A 174;ASN A 220;SER A 224;GLU A 228;ARG A 314;TYR A 315"," MG A 404 (-2.6A);0FV A 400 ( 3.0A);0FV A 400 (-2.7A); MG A 402 (-2.2A); MG A 402 (-2.6A);LA6 A 401 ( 3.8A);0FV A 400 ( 4.4A)","0.66A","5dz2B-5nx7A:39.0","5dz2B-5nx7A:27.97"]]