SIMILAR PATTERNS OF AMINO ACIDS FOR 5DXB_A_ESTA1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 ALA A  59
GLU A  58
LEU A  20
ARG A 311
GLY A  14
 None
 1.33A 5dxbA-1cj2A:
0.0		 5dxbA-1cj2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcq PYK2-ASSOCIATED
PROTEIN BETA

(Mus musculus) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 LEU A 314
GLU A 254
LEU A 521
ARG A 257
HIS A 514
 None
 1.38A 5dxbA-1dcqA:
0.0		 5dxbA-1dcqA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 ALA A 212
GLU A 191
LEU A 298
ARG A 186
LEU A 223
 None
 1.16A 5dxbA-1g0vA:
undetectable		 5dxbA-1g0vA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg3 TRIOSEPHOSPHATE
ISOMERASE

(Pyrococcus
woesei) 		PF00121
(TIM)
PF05690
(ThiG) 		5 ALA A  83
GLU A  82
LEU A  80
ARG A 112
GLY A  77
 None
 1.39A 5dxbA-1hg3A:
0.0		 5dxbA-1hg3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		5 LEU A 134
ALA A 137
GLU A 136
LEU A  99
GLY A  84
 None
 1.06A 5dxbA-1k1xA:
0.3		 5dxbA-1k1xA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mn6 POLYKETIDE SYNTHASE
IV

(Streptomyces
venezuelae) 		PF00975
(Thioesterase) 		5 MET A 271
ALA A 282
LEU A 233
GLY A 146
HIS A 147
 None
 1.29A 5dxbA-1mn6A:
undetectable		 5dxbA-1mn6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A  44
GLU A 109
LEU A 269
MET A 268
GLY A 210
 None
 1.29A 5dxbA-1n7gA:
0.0		 5dxbA-1n7gA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nig HYPOTHETICAL PROTEIN
TA1238

(Thermoplasma
acidophilum) 		PF09155
(DUF1940) 		5 LEU A 102
ALA A 106
GLU A  26
GLY A  35
LEU A  34
 None
 1.26A 5dxbA-1nigA:
0.2		 5dxbA-1nigA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU D 100
GLU D 124
LEU D 133
ARG D 125
GLY D 105
 None
 1.42A 5dxbA-1oy3D:
0.0		 5dxbA-1oy3D:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
LEU A 346
ALA A 350
GLU A 353
LEU A 387
MET A 388
ARG A 394
GLY A 521
HIS A 524
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 (-3.7A)
EST  A   1 ( 4.1A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
 0.30A 5dxbA-1pcgA:
37.8		 5dxbA-1pcgA:
98.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		5 LEU A 408
ALA A 413
GLU A 415
GLY A 493
LEU A 490
 None
 1.37A 5dxbA-1q3sA:
undetectable		 5dxbA-1q3sA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrj HTLV-I CAPSID
PROTEIN

(Primate
T-lymphotropic
virus 1) 		PF00607
(Gag_p24) 		5 LEU A 116
ALA A  82
GLU A  81
GLY A 108
LEU A 109
 None
 1.35A 5dxbA-1qrjA:
undetectable		 5dxbA-1qrjA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermus
thermophilus) 		PF03009
(GDPD) 		5 LEU A  18
ALA A  20
LEU A  30
GLY A  12
HIS A  13
 None
None
None
None
GOL  A 300 (-3.9A)
 1.42A 5dxbA-1vd6A:
undetectable		 5dxbA-1vd6A:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
GLU A 331
LEU A 365
ARG A 372
HIS A 494
 None
 0.51A 5dxbA-1xb7A:
28.9		 5dxbA-1xb7A:
32.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yuz NIGERYTHRIN

(Desulfovibrio
vulgaris) 		PF02915
(Rubrerythrin) 		5 LEU A  65
ALA A  68
GLU A  67
ARG A  55
GLY A 183
 None
 1.35A 5dxbA-1yuzA:
undetectable		 5dxbA-1yuzA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.25A 5dxbA-1z7eA:
undetectable		 5dxbA-1z7eA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		5 ALA C  48
GLU C  35
ARG C 499
HIS B  23
LEU B  24
 None
 1.26A 5dxbA-2advC:
undetectable		 5dxbA-2advC:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		5 GLU C  35
ARG C 499
GLY C 454
HIS B  23
LEU B  24
 None
 1.40A 5dxbA-2advC:
undetectable		 5dxbA-2advC:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ast S-PHASE
KINASE-ASSOCIATED
PROTEIN 1A

(Homo sapiens) 		PF01466
(Skp1)
PF03931
(Skp1_POZ) 		5 LEU A1103
ALA A1106
LEU A1110
GLY A1114
LEU A1116
 None
 1.27A 5dxbA-2astA:
undetectable		 5dxbA-2astA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 ALA A  90
GLU A  93
LEU A  94
GLY A  35
LEU A  36
 None
 1.38A 5dxbA-2c4mA:
undetectable		 5dxbA-2c4mA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 LEU B 509
ALA B 512
GLU B 511
MET B 506
GLY B 773
 None
 1.38A 5dxbA-2fffB:
undetectable		 5dxbA-2fffB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvg ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		5 ALA A 160
GLU A 155
LEU A 315
GLY A 239
LEU A 238
 None
 1.15A 5dxbA-2fvgA:
undetectable		 5dxbA-2fvgA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 268
ALA A 272
GLU A 275
LEU A 309
ARG A 316
HIS A 434
 OHT  A 500 (-4.1A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
 0.61A 5dxbA-2gpvA:
27.7		 5dxbA-2gpvA:
36.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqs PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Escherichia
coli) 		PF01259
(SAICAR_synt) 		5 LEU A 154
ALA A 158
LEU A  61
MET A  58
GLY A 190
 None
None
None
None
ADP  A 238 ( 4.3A)
 1.23A 5dxbA-2gqsA:
undetectable		 5dxbA-2gqsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		5 LEU A 298
ALA A 301
GLU A 300
GLY A 272
LEU A 271
 None
 1.31A 5dxbA-2h1yA:
undetectable		 5dxbA-2h1yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx0 PUTATIVE DNA-BINDING
PROTEIN

(Salmonella
enterica) 		PF03479
(DUF296) 		5 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.30A 5dxbA-2hx0A:
undetectable		 5dxbA-2hx0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 MET A 503
LEU A 506
ALA A 510
MET A 534
GLY A 776
 None
 1.19A 5dxbA-2ivfA:
undetectable		 5dxbA-2ivfA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		5 LEU A 135
ALA A 133
ARG A 279
GLY A 147
LEU A 150
 None
 1.19A 5dxbA-2o5vA:
undetectable		 5dxbA-2o5vA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
LEU A 346
ALA A 350
GLU A 353
LEU A 387
MET A 388
ARG A 394
GLY A 521
HIS A 524
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 (-4.0A)
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
 0.40A 5dxbA-2ocfA:
37.5		 5dxbA-2ocfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 ALA A 228
GLU A 229
ARG A 321
GLY A 524
LEU A 521
 None
 1.22A 5dxbA-2qveA:
undetectable		 5dxbA-2qveA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		5 LEU A 404
ALA A 408
GLU A 411
LEU A 333
GLY A 340
 None
 1.15A 5dxbA-2wokA:
undetectable		 5dxbA-2wokA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		5 LEU A  91
GLU A  89
ARG A 113
GLY A 309
LEU A 311
 None
 1.26A 5dxbA-2x5fA:
undetectable		 5dxbA-2x5fA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ALA A 524
LEU A 493
MET A 492
GLY A 575
LEU A 582
 None
None
None
PGR  A1742 (-4.2A)
None
 1.29A 5dxbA-2xe4A:
undetectable		 5dxbA-2xe4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ALA A 671
GLU A  68
LEU A 689
ARG A 678
GLY A 600
 None
None
None
None
PGR  A1742 (-3.5A)
 1.35A 5dxbA-2xe4A:
undetectable		 5dxbA-2xe4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5c ADRENODOXIN-LIKE
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00111
(Fer2) 		5 ALA A 100
GLU A 101
ARG A  17
GLY A  22
LEU A  93
 None
 1.32A 5dxbA-2y5cA:
undetectable		 5dxbA-2y5cA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		5 ALA A 288
GLU A 291
LEU A 265
GLY A 270
LEU A 273
 None
 1.21A 5dxbA-2yy5A:
undetectable		 5dxbA-2yy5A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zop PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB164

(Thermus
thermophilus) 		PF09701
(Cas_Cmr5) 		5 LEU A  44
GLU A  96
LEU A  70
GLY A  63
LEU A  35
 None
 1.38A 5dxbA-2zopA:
undetectable		 5dxbA-2zopA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akc CYTIDYLATE KINASE

(Thermus
thermophilus) 		PF02224
(Cytidylate_kin) 		5 LEU A  36
ALA A  39
LEU A  84
GLY A  65
LEU A  61
 None
 1.23A 5dxbA-3akcA:
undetectable		 5dxbA-3akcA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		5 LEU A 146
ALA A 268
LEU A 396
GLY A 171
LEU A 167
 None
 1.19A 5dxbA-3d5eA:
undetectable		 5dxbA-3d5eA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 ALA A 196
LEU A 185
ARG A 205
GLY A 171
HIS A 140
 None
None
None
None
ZN  A 302 ( 3.2A)
 1.37A 5dxbA-3dbkA:
undetectable		 5dxbA-3dbkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 310
LEU A 282
MET A 281
GLY A 269
LEU A 292
 None
 1.37A 5dxbA-3dipA:
undetectable		 5dxbA-3dipA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA X 319
GLU X 318
LEU X 314
ARG X  11
GLY X 220
 None
 1.06A 5dxbA-3e3bX:
undetectable		 5dxbA-3e3bX:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ALA A 155
GLU A 154
LEU A 247
ARG A 101
LEU A 111
 None
 1.33A 5dxbA-3fd5A:
undetectable		 5dxbA-3fd5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi0 PUTATIVE
EXOPOLYPHOSPHATASE

(Agrobacterium
fabrum) 		PF02541
(Ppx-GppA) 		5 LEU A  54
GLU A 176
LEU A 172
GLY A  22
LEU A  50
 None
 1.42A 5dxbA-3hi0A:
undetectable		 5dxbA-3hi0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn1 GOLGI PHOSPHOPROTEIN
3

(Homo sapiens) 		PF05719
(GPP34) 		5 LEU A 133
ALA A 136
GLU A 135
ARG A 176
LEU A  94
 None
 1.31A 5dxbA-3kn1A:
undetectable		 5dxbA-3kn1A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn1 GOLGI PHOSPHOPROTEIN
3

(Homo sapiens) 		PF05719
(GPP34) 		5 LEU A 133
ALA A 136
GLU A 135
LEU A 170
LEU A  94
 None
 1.17A 5dxbA-3kn1A:
undetectable		 5dxbA-3kn1A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6v DNA GYRASE SUBUNIT A

(Xanthomonas
campestris) 		PF03989
(DNA_gyraseA_C) 		5 LEU A 659
ALA A 640
GLU A 638
ARG A 637
GLY A 689
 None
 1.36A 5dxbA-3l6vA:
undetectable		 5dxbA-3l6vA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		5 LEU A 248
ALA A 251
GLU A 250
LEU A 186
GLY A 272
 None
None
None
None
PLP  A 701 ( 4.2A)
 1.31A 5dxbA-3nzpA:
undetectable		 5dxbA-3nzpA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rao PUTATIVE
LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		5 MET A  81
LEU A  45
LEU A 321
GLY A 234
LEU A 318
 None
 1.38A 5dxbA-3raoA:
undetectable		 5dxbA-3raoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rit DIPEPTIDE EPIMERASE

(Methylococcus
capsulatus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 306
ALA A 308
LEU A 123
GLY A 349
LEU A 350
 None
 1.25A 5dxbA-3ritA:
undetectable		 5dxbA-3ritA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Francisella
tularensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A 104
ALA A 106
LEU A  71
GLY A  98
LEU A  96
 None
 1.34A 5dxbA-3tqvA:
undetectable		 5dxbA-3tqvA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]

(Saccharomyces
cerevisiae) 		PF05222
(AlaDh_PNT_N) 		5 LEU A  21
ALA A  19
GLU A  11
LEU A  76
ARG A   9
 None
 1.20A 5dxbA-3ugkA:
undetectable		 5dxbA-3ugkA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 LEU A 123
ALA A 430
GLU A 428
ARG A  91
GLY A 436
 None
 1.01A 5dxbA-3v7nA:
undetectable		 5dxbA-3v7nA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 654
GLU A 655
ARG A 649
GLY A 474
LEU A 510
 None
None
None
C8E  A1001 (-4.3A)
None
 1.27A 5dxbA-3v8xA:
undetectable		 5dxbA-3v8xA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voo FATTY ACID
ALPHA-HYDROXYLASE

(Sphingomonas
paucimobilis) 		PF00067
(p450) 		5 LEU A 153
GLU A 117
ARG A 120
GLY A 163
LEU A 165
 None
 1.34A 5dxbA-3vooA:
undetectable		 5dxbA-3vooA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 222
ALA A 113
GLU A 116
ARG A 234
LEU A 187
 LEU  A 222 ( 0.6A)
ALA  A 113 ( 0.0A)
GLU  A 116 ( 0.5A)
ARG  A 234 ( 0.6A)
LEU  A 187 ( 0.5A)
 1.23A 5dxbA-3wd7A:
undetectable		 5dxbA-3wd7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		5 GLU A 813
LEU A 798
MET A 799
ARG A 801
GLY A 833
 None
 1.27A 5dxbA-3wqyA:
0.5		 5dxbA-3wqyA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 ALA A  78
GLU A  81
LEU A 167
GLY A 160
LEU A 159
 None
 1.35A 5dxbA-3wrtA:
undetectable		 5dxbA-3wrtA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bp8 OLIGOPEPTIDASE B

(Trypanosoma
brucei) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ALA A 510
LEU A 479
MET A 478
GLY A 561
LEU A 568
 None
 1.29A 5dxbA-4bp8A:
undetectable		 5dxbA-4bp8A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis) 		PF02361
(CbiQ)
PF07155
(ECF-ribofla_trS) 		5 ALA T 175
GLU T 174
LEU T 208
ARG T 215
GLY S  43
 None
 1.32A 5dxbA-4hzuT:
undetectable		 5dxbA-4hzuT:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis) 		PF02361
(CbiQ)
PF07155
(ECF-ribofla_trS) 		5 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
 None
 1.32A 5dxbA-4hzuT:
undetectable		 5dxbA-4hzuT:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7i RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 ALA A 400
GLU A 397
LEU A 477
ARG A 221
GLY A 482
 None
 1.35A 5dxbA-4i7iA:
undetectable		 5dxbA-4i7iA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE

(Trypanosoma
cruzi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 123
GLU A 122
LEU A  96
ARG A 116
LEU A 110
 None
 1.40A 5dxbA-4iv5A:
undetectable		 5dxbA-4iv5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLU A3143
LEU A3257
MET A3258
GLY A3293
HIS A3404
 None
 1.04A 5dxbA-4kc5A:
undetectable		 5dxbA-4kc5A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 162
GLU A 221
LEU A 116
GLY A 110
LEU A 164
 None
None
None
1UL  A 501 ( 3.7A)
None
 1.36A 5dxbA-4l52A:
undetectable		 5dxbA-4l52A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu1 MAF-LIKE PROTEIN
YCEF

(Escherichia
coli) 		PF02545
(Maf) 		5 LEU A 108
ALA A  53
GLY A 114
HIS A 115
LEU A 116
 None
 0.91A 5dxbA-4lu1A:
undetectable		 5dxbA-4lu1A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA E 318
GLU E 317
LEU E 313
ARG E  10
GLY E 219
 None
 1.08A 5dxbA-4md8E:
undetectable		 5dxbA-4md8E:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 ALA A 287
GLU A 290
LEU A 324
ARG A 331
GLY A 444
 None
 1.02A 5dxbA-4n1yA:
32.2		 5dxbA-4n1yA:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 283
ALA A 287
GLU A 290
LEU A 324
ARG A 331
GLY A 447
 None
 0.49A 5dxbA-4n1yA:
32.2		 5dxbA-4n1yA:
38.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 771
GLU A 770
LEU A 702
ARG A 813
LEU A 761
 None
 1.39A 5dxbA-4n5cA:
undetectable		 5dxbA-4n5cA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2

(Homo sapiens) 		PF00092
(VWA)
PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 LEU B 253
ALA B 255
LEU A  75
GLY A 105
LEU A 103
 None
 1.31A 5dxbA-4nenB:
undetectable		 5dxbA-4nenB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 723
GLU A 720
LEU A 815
GLY A 808
LEU A 810
 None
 1.40A 5dxbA-4otdA:
undetectable		 5dxbA-4otdA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3h KSHV PROTEASE

(Human
gammaherpesvirus
8) 		PF00716
(Peptidase_S21) 		5 ALA A 154
GLU A 155
LEU A 173
GLY A  57
LEU A  56
 None
 1.27A 5dxbA-4p3hA:
undetectable		 5dxbA-4p3hA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A 894
GLU A 887
ARG A 920
GLY A 879
LEU A 877
 None
 1.41A 5dxbA-4pj6A:
undetectable		 5dxbA-4pj6A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
 None
 1.40A 5dxbA-4q5nA:
undetectable		 5dxbA-4q5nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74

(Saccharomyces
cerevisiae) 		PF05719
(GPP34) 		5 LEU A 141
GLU A 143
LEU A 177
ARG A 183
GLY A  98
 None
 1.30A 5dxbA-4tu3A:
undetectable		 5dxbA-4tu3A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND
PATE

(Lyngbya
aestuarii;
uncultured
Prochloron sp.) 		PF02624
(YcaO)
no annotation 		5 ALA C  33
GLU C  32
LEU C  34
GLY A  27
HIS A  12
 None
 1.41A 5dxbA-4v1uC:
undetectable		 5dxbA-4v1uC:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  31
ALA A  35
GLY A  56
HIS A  57
LEU A  55
 None
 1.16A 5dxbA-5bz4A:
undetectable		 5dxbA-5bz4A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B

(Homo sapiens) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		5 MET A 273
LEU A 269
GLU A 267
GLY A 238
LEU A 235
 None
 1.40A 5dxbA-5dseA:
undetectable		 5dxbA-5dseA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwd ESTERASE

(Pelagibacterium
halotolerans) 		PF02230
(Abhydrolase_2) 		5 LEU A 162
ALA A 191
LEU A 181
GLY A 143
LEU A 125
 None
 1.29A 5dxbA-5dwdA:
undetectable		 5dxbA-5dwdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		5 ALA A 694
GLU A 697
LEU A 654
ARG A 145
GLY A 647
 None
None
None
None
FLC  A1002 (-3.3A)
 1.30A 5dxbA-5fdnA:
2.9		 5dxbA-5fdnA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ALA A 249
LEU A 265
ARG A 272
GLY A 299
LEU A 297
 None
 1.25A 5dxbA-5giuA:
undetectable		 5dxbA-5giuA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC

(Zea mays) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A  77
ALA A 227
LEU A 231
GLY A 104
LEU A 185
 None
 1.37A 5dxbA-5h8yA:
undetectable		 5dxbA-5h8yA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		5 ALA A 341
GLU A 340
LEU A 424
ARG A 395
GLY A 429
 None
None
None
SO4  A 703 (-3.7A)
None
 1.36A 5dxbA-5icqA:
undetectable		 5dxbA-5icqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Legionella
pneumophila) 		PF00290
(Trp_syntA) 		5 MET A 261
ALA A  45
LEU A  48
GLY A 233
LEU A 236
 None
 1.25A 5dxbA-5k9xA:
undetectable		 5dxbA-5k9xA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9o DEOXYFRUCTOSYL-AMINO
ACID TRANSPORTER
PERIPLASMIC BINDING
PROTEIN

(Agrobacterium
fabrum) 		PF00497
(SBP_bac_3) 		5 ALA A 168
GLU A 169
LEU A 177
GLY A 153
LEU A 151
 None
 1.32A 5dxbA-5l9oA:
undetectable		 5dxbA-5l9oA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lvc VP1

(Aichivirus A) 		no annotation 5 LEU a 196
ALA a 122
LEU a 120
MET a 119
GLY a  70
 None
 1.21A 5dxbA-5lvca:
undetectable		 5dxbA-5lvca:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlv -

(-) 		no annotation 5 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
 None
 0.93A 5dxbA-5mlvG:
undetectable		 5dxbA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 LEU A 245
ALA A 414
LEU A 255
MET A 256
LEU A 447
 None
 1.22A 5dxbA-5oltA:
undetectable		 5dxbA-5oltA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 295
LEU A 298
ALA A 302
GLU A 305
LEU A 339
MET A 340
ARG A 346
GLY A 472
HIS A 475
LEU A 476
 EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 (-4.1A)
EST  A 601 (-4.0A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
 0.35A 5dxbA-5toaA:
31.7		 5dxbA-5toaA:
56.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		5 LEU A 118
ALA A 120
ARG A   3
GLY A 146
LEU A 145
 None
 1.40A 5dxbA-5tvgA:
undetectable		 5dxbA-5tvgA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4n FRUCTOSE-1

(Neisseria
gonorrhoeae) 		PF01116
(F_bP_aldolase) 		5 ALA A 193
GLU A 142
LEU A 146
GLY A 152
LEU A 149
 None
 0.94A 5dxbA-5u4nA:
undetectable		 5dxbA-5u4nA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhd RNA POLYMERASE SIGMA
FACTOR SIGA

(Mycobacterium
tuberculosis) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		5 GLU F 398
LEU F 386
ARG F 392
GLY F 380
LEU F 379
 None
 1.30A 5dxbA-5uhdF:
undetectable		 5dxbA-5uhdF:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzh NAFOA.00085.B

(Naegleria
fowleri) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A  49
GLU A 113
LEU A 272
MET A 271
GLY A 213
 None
 1.31A 5dxbA-5uzhA:
undetectable		 5dxbA-5uzhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq0 STAGE 0 SPORULATION
PROTEIN

(Paenisporosarcina
sp. TG-14) 		no annotation 5 MET B  71
LEU B  68
ALA B  66
MET B  59
LEU B  42
 None
 1.40A 5dxbA-5wq0B:
undetectable		 5dxbA-5wq0B:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 LEU A 255
ALA A 258
GLU A 257
LEU A 201
GLY A 218
 None
 1.28A 5dxbA-5wy4A:
undetectable		 5dxbA-5wy4A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x87 BESTROPHIN

(Klebsiella
pneumoniae) 		no annotation 5 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.38A 5dxbA-5x87A:
undetectable		 5dxbA-5x87A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 5 ALA A  59
GLU A  58
LEU A  20
ARG A 311
GLY A  14
 None
 1.32A 5dxbA-6dllA:
undetectable		 5dxbA-6dllA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA

(Chromobacterium
violaceum) 		no annotation 5 LEU B 377
ALA B 408
GLU B 407
LEU B 411
GLY B 383
 None
 1.41A 5dxbA-6esdB:
undetectable		 5dxbA-6esdB:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpl GDP-MANNOSE 4,6
DEHYDRATASE

(Homo sapiens) 		no annotation 5 LEU B  39
GLU B 104
LEU B 263
MET B 262
GLY B 204
 None
 1.29A 5dxbA-6gplB:
undetectable		 5dxbA-6gplB:
undetectable