SIMILAR PATTERNS OF AMINO ACIDS FOR 5DV4_A_NMYA601_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cs1 | PROTEIN(CYSTATHIONINEGAMMA-SYNTHASE) (Escherichiacoli) |
PF01053(Cys_Met_Meta_PP) | 5 | TYR A 199ASN A 283HIS A 277LEU A 376ILE A 262 | None | 1.26A | 5dv4A-1cs1A:undetectable | 5dv4A-1cs1A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eso | CU, ZN SUPEROXIDEDISMUTASE (Escherichiacoli) |
PF00080(Sod_Cu) | 5 | LEU A 33PRO A 83LEU A 102PHE A 29ILE A 45 | None | 1.47A | 5dv4A-1esoA:undetectable | 5dv4A-1esoA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fml | RETINOL DEHYDRATASE (Spodopterafrugiperda) |
PF00685(Sulfotransfer_1) | 5 | TYR A 182PRO A 171ASP A 107LEU A 150PHE A 67 | None | 1.40A | 5dv4A-1fmlA:undetectable | 5dv4A-1fmlA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ihp | PHYTASE (Aspergillusficuum) |
PF00328(His_Phos_2) | 5 | LEU A 113HIS A 338PRO A 379LEU A 346ILE A 342 | None | 1.25A | 5dv4A-1ihpA:undetectable | 5dv4A-1ihpA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kq0 | METHIONINEAMINOPEPTIDASE 2 (Homo sapiens) |
PF00557(Peptidase_M24) | 5 | LEU A 447PRO A 220ASP A 262ILE A 338HIS A 331 | NoneNone ZN A 479 (-2.2A)MED A 601 ( 4.7A) ZN A 480 ( 3.4A) | 1.39A | 5dv4A-1kq0A:undetectable | 5dv4A-1kq0A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1l | RIBONUCLEOSIDETRIPHOSPHATEREDUCTASE (Lactobacillusleichmannii) |
PF02867(Ribonuc_red_lgC) | 5 | LEU A 139ASN A 415LEU A 296PHE A 239ILE A 175 | None | 1.27A | 5dv4A-1l1lA:undetectable | 5dv4A-1l1lA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mwo | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | LEU A 6LEU A 89PHE A 192ILE A 93HIS A 97 | None | 1.36A | 5dv4A-1mwoA:undetectable | 5dv4A-1mwoA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nw1 | CHOLINE KINASE (49.2KD) (Caenorhabditiselegans) |
PF01633(Choline_kinase) | 5 | ASN A 115HIS A 121LEU A 132PHE A 251ILE A 128 | None | 1.30A | 5dv4A-1nw1A:undetectable | 5dv4A-1nw1A:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pmi | PHOSPHOMANNOSEISOMERASE (Candidaalbicans) |
PF01238(PMI_typeI) | 5 | LEU A 279ASN A 272LEU A 245PHE A 149ILE A 288 | None | 1.43A | 5dv4A-1pmiA:undetectable | 5dv4A-1pmiA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t1u | CHOLINEO-ACETYLTRANSFERASE (Rattusnorvegicus) |
PF00755(Carn_acyltransf) | 5 | TYR A 562ASP A 424LEU A 607PHE A 583ILE A 427 | None | 1.14A | 5dv4A-1t1uA:undetectable | 5dv4A-1t1uA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t71 | PHOSPHATASE (Mycoplasmapneumoniae) |
PF13277(YmdB) | 5 | HIS A 185ASP A 12ASN A 44LEU A 51HIS A 158 | FE A 301 (-3.5A) FE A 301 (-3.2A) FE A 301 (-2.7A)None FE A 302 (-3.5A) | 1.32A | 5dv4A-1t71A:5.0 | 5dv4A-1t71A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t71 | PHOSPHATASE (Mycoplasmapneumoniae) |
PF13277(YmdB) | 5 | LEU A 130HIS A 185ASP A 12ASN A 44LEU A 51 | None FE A 301 (-3.5A) FE A 301 (-3.2A) FE A 301 (-2.7A)None | 1.45A | 5dv4A-1t71A:5.0 | 5dv4A-1t71A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xp3 | ENDONUCLEASE IV (Bacillusanthracis) |
PF01261(AP_endonuc_2) | 5 | TYR A 34HIS A 183PRO A 262ASP A 180ASN A 217 | None ZN A 302 (-3.2A)None ZN A 303 ( 3.3A)None | 1.38A | 5dv4A-1xp3A:undetectable | 5dv4A-1xp3A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ygp | YEAST GLYCOGENPHOSPHORYLASE (Saccharomycescerevisiae) |
PF00343(Phosphorylase) | 5 | HIS A 728ASP A 769LEU A 761PHE A 581ILE A 765 | None | 1.43A | 5dv4A-1ygpA:undetectable | 5dv4A-1ygpA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yx1 | HYPOTHETICAL PROTEINPA2260 (Pseudomonasaeruginosa) |
PF01261(AP_endonuc_2) | 5 | LEU A 44ASN A 164HIS A 187PRO A 230ILE A 227 | None | 1.36A | 5dv4A-1yx1A:undetectable | 5dv4A-1yx1A:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zr5 | H2AFY PROTEIN (Homo sapiens) |
PF01661(Macro) | 5 | LEU A 205ASN A 317LEU A 329PHE A 349ILE A 328 | None | 1.44A | 5dv4A-1zr5A:undetectable | 5dv4A-1zr5A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zwx | SPHINGOMYELINASE-C (Listeriaivanovii) |
PF03372(Exo_endo_phos) | 5 | TYR A 273HIS A 185ASP A 229ASN A 231HIS A 325 | NoneNoneNonePO4 A 401 ( 4.3A)PO4 A 401 (-3.8A) | 1.02A | 5dv4A-1zwxA:19.7 | 5dv4A-1zwxA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a7m | N-ACYL HOMOSERINELACTONE HYDROLASE (Bacillusthuringiensis) |
PF00753(Lactamase_B) | 5 | HIS A 235ASP A 191LEU A 176ILE A 190HIS A 104 | ZN A 251 (-3.3A) ZN A 251 ( 2.4A)NoneNone ZN A 252 (-3.3A) | 1.15A | 5dv4A-2a7mA:undetectable | 5dv4A-2a7mA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2adu | METHIONINEAMINOPEPTIDASE 2 (Homo sapiens) |
PF00557(Peptidase_M24) | 5 | LEU A 447PRO A 220ASP A 262ILE A 338HIS A 331 | NoneNone CO A 501 (-2.2A)R20 A 906 ( 4.5A) CO A 502 ( 3.2A) | 1.39A | 5dv4A-2aduA:undetectable | 5dv4A-2aduA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2az4 | HYPOTHETICAL PROTEINEF2904 (Enterococcusfaecalis) |
PF12706(Lactamase_B_2) | 5 | HIS A 97ASP A 96LEU A 406PHE A 222ILE A 18 | ZN A 602 (-3.3A) ZN A 602 (-2.8A)NoneNoneNone | 1.45A | 5dv4A-2az4A:2.5 | 5dv4A-2az4A:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c0z | NOVW (Streptomycesniveus) |
PF00908(dTDP_sugar_isom) | 5 | LEU A 130TYR A 132ASP A 168LEU A 153HIS A 62 | NoneNoneSO4 A1191 ( 4.3A)NoneNone | 1.08A | 5dv4A-2c0zA:undetectable | 5dv4A-2c0zA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ewo | PUTATIVE AGMATINEDEIMINASE (Streptococcusmutans) |
PF04371(PAD_porph) | 5 | LEU A 160ASN A 310HIS A 360LEU A 30ILE A 98 | None | 1.10A | 5dv4A-2ewoA:undetectable | 5dv4A-2ewoA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fy2 | CHOLINEO-ACETYLTRANSFERASE (Homo sapiens) |
PF00755(Carn_acyltransf) | 5 | TYR A 552ASP A 414LEU A 597PHE A 573ILE A 417 | None | 1.14A | 5dv4A-2fy2A:undetectable | 5dv4A-2fy2A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gcu | PUTATIVEHYDROXYACYLGLUTATHIONE HYDROLASE 3 (Arabidopsisthaliana) |
PF00753(Lactamase_B) | 5 | ASN A 243HIS A 74ASP A 45LEU A 42ILE A 44 | None | 1.27A | 5dv4A-2gcuA:undetectable | 5dv4A-2gcuA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gsn | PHOSPHODIESTERASE-NUCLEOTIDEPYROPHOSPHATASE (Xanthomonascitri) |
PF01663(Phosphodiest) | 5 | TYR A 365PRO A 92ASP A 210LEU A 123HIS A 214 | NoneNone ZN A1001 (-2.0A)None ZN A1001 (-3.2A) | 1.27A | 5dv4A-2gsnA:undetectable | 5dv4A-2gsnA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibn | INOSITOL OXYGENASE (Homo sapiens) |
PF05153(MIOX) | 5 | LEU A 254HIS A 194PRO A 224ASP A 195LEU A 185 | None FE A 704 ( 3.5A)NoneI1N A 710 ( 4.8A)None | 1.40A | 5dv4A-2ibnA:undetectable | 5dv4A-2ibnA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5f | PUTATIVE NUDIXHYDROLASE DR_0079 (Deinococcusradiodurans) |
PF00293(NUDIX) | 5 | PRO A 101ASP A 95LEU A 121PHE A 82ILE A 94 | None | 1.37A | 5dv4A-2o5fA:undetectable | 5dv4A-2o5fA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qps | ALPHA-AMYLASE TYPE AISOZYME (Hordeum vulgare) |
PF00128(Alpha-amylase)PF07821(Alpha-amyl_C2) | 5 | LEU A 201LEU A 71PHE A 174ILE A 75HIS A 79 | None | 1.24A | 5dv4A-2qpsA:undetectable | 5dv4A-2qpsA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r0h | CGL3 LECTIN (Coprinopsiscinerea) |
PF00337(Gal-bind_lectin) | 5 | LEU A 5HIS A 60PRO A 143PHE A 145ILE A 63 | NoneCTO A 165 (-3.6A)NoneNoneNone | 1.42A | 5dv4A-2r0hA:undetectable | 5dv4A-2r0hA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rch | CYTOCHROME P450 74A (Arabidopsisthaliana) |
PF00067(p450) | 5 | LEU A 201ASN A 346HIS A 345PHE A 194ILE A 488 | None | 1.43A | 5dv4A-2rchA:undetectable | 5dv4A-2rchA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x2u | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF00028(Cadherin) | 5 | LEU A 118ASN A 83LEU A 95PHE A 147ILE A 86 | None | 1.27A | 5dv4A-2x2uA:undetectable | 5dv4A-2x2uA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x7j | 2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE-1-CARBOXYLATESYNTHASE (Bacillussubtilis) |
PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N)PF16582(TPP_enzyme_M_2) | 5 | TYR A 271ASN A 431LEU A 400PHE A 415ILE A 424 | None | 1.46A | 5dv4A-2x7jA:undetectable | 5dv4A-2x7jA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3czm | L-LACTATEDEHYDROGENASE (Toxoplasmagondii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ASN A 110ASP A 143LEU A 281PHE A 315ILE A 287 | None | 1.05A | 5dv4A-3czmA:undetectable | 5dv4A-3czmA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fi9 | MALATE DEHYDROGENASE (Porphyromonasgingivalis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ASP A 288ASN A 290LEU A 301PHE A 268ILE A 289 | None | 1.38A | 5dv4A-3fi9A:undetectable | 5dv4A-3fi9A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fmq | METHIONINEAMINOPEPTIDASE 2 (Encephalitozooncuniculi) |
PF00557(Peptidase_M24) | 5 | LEU A 327PRO A 98ASP A 141ILE A 217HIS A 210 | NoneNone FE A 452 ( 2.2A)FUG A 481 (-4.5A) FE A 451 (-3.4A) | 1.45A | 5dv4A-3fmqA:undetectable | 5dv4A-3fmqA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g6s | PUTATIVEENDONUCLEASE/EXONUCLEASE/PHOSPHATASEFAMILY PROTEIN (Bacteroidesvulgatus) |
PF03372(Exo_endo_phos) | 5 | HIS A 138ASP A 172ASN A 174ILE A 223HIS A 251 | None | 0.33A | 5dv4A-3g6sA:27.3 | 5dv4A-3g6sA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gip | N-ACYL-D-GLUTAMATEDEACYLASE (Bordetellabronchiseptica) |
PF07969(Amidohydro_3) | 5 | LEU A 407ASP A 268LEU A 234ILE A 267HIS A 357 | None | 1.45A | 5dv4A-3gipA:undetectable | 5dv4A-3gipA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2i | ESTERASE (Xanthomonasoryzae) |
PF03583(LIP) | 5 | LEU A 211HIS A 377PRO A 204ASP A 336LEU A 361 | None | 1.39A | 5dv4A-3h2iA:undetectable | 5dv4A-3h2iA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i16 | ALUMINUM RESISTANCEPROTEIN (Clostridiumnovyi) |
PF06838(Met_gamma_lyase) | 5 | LEU A 36ASN A 218PRO A 297ASN A 244ILE A 388 | None | 1.42A | 5dv4A-3i16A:undetectable | 5dv4A-3i16A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ky8 | PUTATIVE RIBOFLAVINBIOSYNTHESIS PROTEIN (Shewanellaloihica) |
PF01872(RibD_C) | 5 | LEU A 41ASN A 104ASN A 3LEU A 123ILE A 128 | None | 1.40A | 5dv4A-3ky8A:undetectable | 5dv4A-3ky8A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l1w | UNCHARACTERIZEDPROTEIN (Enterococcusfaecalis) |
PF03372(Exo_endo_phos) | 5 | HIS A 132ASP A 166ASN A 168ILE A 214HIS A 242 | None | 0.23A | 5dv4A-3l1wA:25.9 | 5dv4A-3l1wA:25.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mm5 | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT BETA (Archaeoglobusfulgidus) |
PF00037(Fer4)PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | TYR B 159ASN B 105LEU B 103PHE B 56ILE B 104 | None | 1.16A | 5dv4A-3mm5B:undetectable | 5dv4A-3mm5B:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nfz | ASPARTOACYLASE-2 (Mus musculus) |
PF04952(AstE_AspA) | 5 | LEU A 100HIS A 116LEU A 138PHE A 111ILE A 174 | None ZN A 319 (-3.4A)NoneNoneNone | 1.11A | 5dv4A-3nfzA:undetectable | 5dv4A-3nfzA:20.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ngo | CCR4-NOTTRANSCRIPTIONCOMPLEX SUBUNIT6-LIKE (Homo sapiens) |
PF03372(Exo_endo_phos) | 12 | LEU A 206TYR A 207ASN A 325HIS A 360PRO A 365LYS A 371ASP A 410ASN A 412LEU A 414PHE A 484ILE A 488HIS A 529 | NoneNoneNoneNoneNoneNone MG A 556 (-2.8A) MG A 556 (-3.2A)NoneNoneNone MG A 556 (-4.2A) | 0.32A | 5dv4A-3ngoA:57.3 | 5dv4A-3ngoA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ngo | CCR4-NOTTRANSCRIPTIONCOMPLEX SUBUNIT6-LIKE (Homo sapiens) |
PF03372(Exo_endo_phos) | 6 | TYR A 207ASP A 489LEU A 414PHE A 484ILE A 488HIS A 529 | NoneNoneNoneNoneNone MG A 556 (-4.2A) | 1.25A | 5dv4A-3ngoA:57.3 | 5dv4A-3ngoA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3om9 | LACTATEDEHYDROGENASE (Toxoplasmagondii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ASN A 110ASP A 143LEU A 281PHE A 315ILE A 287 | None | 1.06A | 5dv4A-3om9A:undetectable | 5dv4A-3om9A:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qcw | NEUREXIN-1-ALPHA (Bos taurus) |
PF00008(EGF)PF02210(Laminin_G_2) | 5 | TYR A 605ASN A 439ASP A 657LEU A 620PHE A 548 | None | 1.37A | 5dv4A-3qcwA:undetectable | 5dv4A-3qcwA:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s95 | LIM DOMAIN KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 391ASN A 462ASP A 531ILE A 457HIS A 452 | None | 1.21A | 5dv4A-3s95A:undetectable | 5dv4A-3s95A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sr6 | XANTHINEDEHYDROGENASE/OXIDASE (Bos taurus) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | LEU C 959TYR C 947ASN C1145PHE C 883ILE C 714 | None | 1.48A | 5dv4A-3sr6C:undetectable | 5dv4A-3sr6C:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ssz | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME,N-TERMINAL DOMAINPROTEIN (Rhodobacteraceaebacterium KLH11) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 143PRO A 338ASN A 326LEU A 309ILE A 325 | None | 1.47A | 5dv4A-3sszA:undetectable | 5dv4A-3sszA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tal | DNA DOUBLE-STRANDBREAK REPAIR PROTEINNURA (Pyrococcusfuriosus) |
PF09376(NurA) | 5 | LEU A 133ASN A 147LEU A 166PHE A 355ILE A 277 | None | 1.33A | 5dv4A-3talA:undetectable | 5dv4A-3talA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tji | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME,N-TERMINAL DOMAINPROTEIN (Enterobactersp. 638) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ASN A 75ASP A 94LEU A 323PHE A 113ILE A 287 | None | 1.38A | 5dv4A-3tjiA:undetectable | 5dv4A-3tjiA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tni | CYCLIN-T1 (Homo sapiens) |
PF00134(Cyclin_N) | 5 | LEU B 184HIS B 154ASN B 60LEU B 88ILE B 59 | None | 1.43A | 5dv4A-3tniB:undetectable | 5dv4A-3tniB:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqx | 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE (Coxiellaburnetii) |
PF00155(Aminotran_1_2) | 5 | ASN A 153ASP A 179ASN A 133PHE A 117ILE A 137 | NonePLP A 397 ( 4.1A)NoneNoneNone | 1.37A | 5dv4A-3tqxA:undetectable | 5dv4A-3tqxA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uo2 | J-TYPE CO-CHAPERONEJAC1, MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00226(DnaJ)PF07743(HSCB_C) | 5 | ASN A 147PRO A 27LEU A 69PHE A 22ILE A 31 | None | 1.40A | 5dv4A-3uo2A:undetectable | 5dv4A-3uo2A:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vw5 | CELLOBIOSE2-EPIMERASE (Ruminococcusalbus) |
PF07221(GlcNAc_2-epim) | 5 | LEU A 49ASN A 375LEU A 10PHE A 56ILE A 14 | None | 1.24A | 5dv4A-3vw5A:undetectable | 5dv4A-3vw5A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9u | PUTATIVE LIPASE (Proteusmirabilis) |
PF00561(Abhydrolase_1) | 5 | ASN A 210HIS A 216ASP A 253PHE A 143ILE A 255 | None | 1.49A | 5dv4A-3w9uA:undetectable | 5dv4A-3w9uA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x1o | ROQUIN-1 (Homo sapiens) |
no annotation | 5 | LEU A 204TYR A 276LEU A 324ILE A 320HIS A 316 | None | 1.14A | 5dv4A-3x1oA:undetectable | 5dv4A-3x1oA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ziu | LEUCYL-TRNASYNTHETASE (Mycoplasmamobile) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 5 | ASN A 492HIS A 491ASP A 535LEU A 72ILE A 538 | None | 1.39A | 5dv4A-3ziuA:undetectable | 5dv4A-3ziuA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b2o | YMDBPHOSPHODIESTERASE (Bacillussubtilis) |
PF13277(YmdB) | 5 | HIS A 177ASP A 8ASN A 40LEU A 47HIS A 150 | FE2 A1266 ( 3.3A)FE2 A1266 (-3.1A)FE2 A1266 ( 2.5A)NoneFE2 A1267 (-3.3A) | 1.27A | 5dv4A-4b2oA:5.1 | 5dv4A-4b2oA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bxw | FACTOR XA (Pseudonajatextilis) |
PF00089(Trypsin)PF14670(FXa_inhibition) | 5 | TYR A 327ASN A 135HIS A 374LEU A 207ILE A 376 | None | 1.34A | 5dv4A-4bxwA:undetectable | 5dv4A-4bxwA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fdj | N-ACETYLGALACTOSAMINE-6-SULFATASE (Homo sapiens) |
PF00884(Sulfatase)PF14707(Sulfatase_C) | 5 | ASN A 303PRO A 77ASP A 40ASN A 289HIS A 236 | NoneNone CA A 603 (-3.0A) CA A 603 (-2.9A)NGA A 604 (-3.3A) | 1.42A | 5dv4A-4fdjA:undetectable | 5dv4A-4fdjA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hl4 | TBC1 DOMAIN FAMILYMEMBER 20 (Homo sapiens) |
PF00566(RabGAP-TBC) | 5 | HIS A 227ASP A 148LEU A 155PHE A 110HIS A 147 | None | 1.29A | 5dv4A-4hl4A:undetectable | 5dv4A-4hl4A:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k17 | LEUCINE-RICHREPEAT-CONTAININGPROTEIN 16A (Mus musculus) |
PF13516(LRR_6) | 5 | LEU A 354ASN A 398LEU A 339PHE A 360ILE A 367 | None | 1.48A | 5dv4A-4k17A:undetectable | 5dv4A-4k17A:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kjr | CATION EXCHANGERYFKE (Bacillussubtilis) |
PF01699(Na_Ca_ex) | 5 | LEU A 174HIS A 256ASN A 69LEU A 92ILE A 282 | None | 1.45A | 5dv4A-4kjrA:undetectable | 5dv4A-4kjrA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mz0 | CURL (Mooreaproducens) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A 424ASN A 316LEU A 328PHE A 363ILE A 324 | None | 1.14A | 5dv4A-4mz0A:undetectable | 5dv4A-4mz0A:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ntl | LIPOPROTEIN, YAECFAMILY (Enterococcusfaecalis) |
PF03180(Lipoprotein_9) | 5 | LEU A 206PRO A 136LEU A 149PHE A 116ILE A 148 | None | 1.48A | 5dv4A-4ntlA:undetectable | 5dv4A-4ntlA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qik | ROQUIN-1 (Homo sapiens) |
no annotation | 5 | LEU A 204TYR A 276LEU A 324ILE A 320HIS A 316 | None | 1.16A | 5dv4A-4qikA:undetectable | 5dv4A-4qikA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qpm | MITOTIC CHECKPOINTSERINE/THREONINE-PROTEIN KINASE BUB1 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 841ASN A 922ASP A 987ILE A 914HIS A 909 | None MG A1502 ( 2.6A)NoneNoneNone | 1.38A | 5dv4A-4qpmA:undetectable | 5dv4A-4qpmA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r2h | STIV B204 ATPASE (Sulfolobusturretedicosahedralvirus 1) |
no annotation | 5 | ASP A 39LEU A 133PHE A 109ILE A 102HIS A 41 | ZN A 300 (-2.1A)NoneNoneNone ZN A 300 (-3.0A) | 1.41A | 5dv4A-4r2hA:undetectable | 5dv4A-4r2hA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ruw | ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE (Beutenbergiacavernae) |
PF03372(Exo_endo_phos) | 5 | HIS A 197ASP A 232ASN A 234ILE A 292HIS A 318 | None | 0.20A | 5dv4A-4ruwA:23.9 | 5dv4A-4ruwA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ux8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF00028(Cadherin) | 5 | LEU A 118ASN A 83LEU A 95PHE A 147ILE A 86 | None | 1.26A | 5dv4A-4ux8A:undetectable | 5dv4A-4ux8A:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wu0 | SIMILAR TO YTER(BACILUS SUBTILIS) (Clostridiumacetobutylicum) |
PF07470(Glyco_hydro_88) | 5 | TYR A 334ASN A 73HIS A 119ASP A 130HIS A 176 | None | 1.24A | 5dv4A-4wu0A:undetectable | 5dv4A-4wu0A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0v | 2',5'-PHOSPHODIESTERASE 12 (Homo sapiens) |
PF03372(Exo_endo_phos) | 8 | LEU A 317TYR A 318HIS A 456PRO A 461ASP A 496ASN A 498PHE A 556HIS A 599 | NoneNoneNoneGOL A 706 (-3.9A)NoneGOL A 706 (-4.8A)GOL A 706 ( 4.7A)None | 0.64A | 5dv4A-4z0vA:39.5 | 5dv4A-4z0vA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z31 | ROQUIN-2 (Homo sapiens) |
no annotation | 5 | LEU A 201TYR A 273LEU A 321ILE A 317HIS A 313 | None | 1.13A | 5dv4A-4z31A:undetectable | 5dv4A-4z31A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z4l | CELLOBIOSE2-EPIMERASE (Caldicellulosiruptorsaccharolyticus) |
PF07221(GlcNAc_2-epim) | 5 | LEU A 53ASN A 378LEU A 14PHE A 60ILE A 18 | None | 1.21A | 5dv4A-4z4lA:undetectable | 5dv4A-4z4lA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a52 | CALCIUM-DEPENDENTLIPID-BINDINGDOMAIN-CONTAININGPROTEIN (Arabidopsisthaliana) |
PF00168(C2) | 5 | LEU A 145ASN A 53LEU A 8PHE A 88ILE A 10 | None | 1.35A | 5dv4A-5a52A:undetectable | 5dv4A-5a52A:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aho | 5' EXONUCLEASEAPOLLO (Homo sapiens) |
PF07522(DRMBL) | 5 | ASN A 148HIS A 276ASP A 120ILE A 297HIS A 36 | NoneTLA A1319 ( 3.9A) ZN A1320 (-2.5A)None ZN A1320 ( 3.4A) | 1.31A | 5dv4A-5ahoA:undetectable | 5dv4A-5ahoA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f5f | ROQUIN-1 (Mus musculus) |
no annotation | 5 | LEU A 204TYR A 276LEU A 324ILE A 320HIS A 316 | None | 1.17A | 5dv4A-5f5fA:undetectable | 5dv4A-5f5fA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ggg | PROTEINO-LINKED-MANNOSEBETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE1 (Homo sapiens) |
PF03071(GNT-I)PF15711(ILEI) | 5 | LEU A 597HIS A 520ASN A 426LEU A 439PHE A 615 | None | 1.37A | 5dv4A-5gggA:2.3 | 5dv4A-5gggA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h28 | OXYSTEROL-BINDINGPROTEIN HOMOLOG 1 (Saccharomycescerevisiae) |
PF13637(Ank_4) | 5 | PRO A 223ASP A 188ASN A 190LEU A 216ILE A 189 | None | 1.41A | 5dv4A-5h28A:undetectable | 5dv4A-5h28A:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hqj | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Paraburkholderiagraminis) |
PF13407(Peripla_BP_4) | 5 | LEU A 251ASN A 95ASP A 118ASN A 166PHE A 248 | NoneNone64K A 401 (-2.7A)64K A 401 (-2.6A)64K A 401 ( 4.9A) | 1.36A | 5dv4A-5hqjA:undetectable | 5dv4A-5hqjA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hqn | SPHINGOMYELINPHOSPHODIESTERASE (Mus musculus) |
PF00149(Metallophos) | 5 | HIS A 206ASP A 276LEU A 339PHE A 325HIS A 423 | ZN A 701 ( 3.3A) ZN A 702 (-2.3A)NoneNone ZN A 702 (-3.2A) | 1.39A | 5dv4A-5hqnA:4.3 | 5dv4A-5hqnA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i85 | SPHINGOMYELINPHOSPHODIESTERASE (Homo sapiens) |
PF00149(Metallophos) | 5 | HIS A 208ASP A 278LEU A 341PHE A 327HIS A 425 | ZN A 715 ( 3.4A) ZN A 714 (-2.6A)NoneNone ZN A 714 (-3.2A) | 1.34A | 5dv4A-5i85A:4.3 | 5dv4A-5i85A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jnm | MANNITOL-1-PHOSPHATE5-DEHYDROGENASE (Staphylococcusaureus) |
no annotation | 5 | ASN A 140HIS A 143LEU A 127PHE A 101ILE A 114 | None | 1.46A | 5dv4A-5jnmA:undetectable | 5dv4A-5jnmA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jp6 | PUTATIVEPOLYSACCHARIDEDEACETYLASE (Bdellovibriobacteriovorus) |
PF01522(Polysacc_deac_1) | 5 | ASN A 95PRO A 179LEU A 188PHE A 200ILE A 187 | None | 1.27A | 5dv4A-5jp6A:undetectable | 5dv4A-5jp6A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lpy | PROTEINBRASSINOSTEROIDINSENSITIVE 1 (Arabidopsisthaliana) |
PF00069(Pkinase) | 5 | ASN A1014ASP A1068LEU A1041ILE A1006HIS A 998 | ATP A1200 (-3.6A)NoneSEP A1042 ( 3.7A)NoneNone | 1.44A | 5dv4A-5lpyA:undetectable | 5dv4A-5lpyA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lpz | PROTEINBRASSINOSTEROIDINSENSITIVE 1 (Arabidopsisthaliana) |
PF00069(Pkinase) | 5 | ASN A1014ASP A1068LEU A1041ILE A1006HIS A 998 | ADP A1200 (-3.6A)NoneSEP A1042 ( 3.7A)NoneNone | 1.42A | 5dv4A-5lpzA:undetectable | 5dv4A-5lpzA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m1b | 3-OCTAPRENYL-4-HYDROXYBENZOATECARBOXY-LYASE (Escherichiacoli) |
PF01977(UbiD) | 5 | LEU A 22LEU A 229PHE A 67ILE A 228HIS A 318 | None | 1.37A | 5dv4A-5m1bA:undetectable | 5dv4A-5m1bA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mf1 | FUSION PROTEINHAP2/GCS1 (Chlamydomonasreinhardtii) |
PF10699(HAP2-GCS1) | 5 | HIS A 287PRO A 293LEU A 306PHE A 230ILE A 232 | None | 1.29A | 5dv4A-5mf1A:undetectable | 5dv4A-5mf1A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ms7 | LEGIONELLAPNEUMOPHILA EFFECTORPROTEIN RAVZ (Legionellapneumophila) |
no annotation | 5 | LEU A 68ASP A 197LEU A 224PHE A 163HIS A 176 | None | 1.32A | 5dv4A-5ms7A:undetectable | 5dv4A-5ms7A:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oyn | DEHYDRATASE,ILVD/EDD FAMILY (Caulobactervibrioides) |
no annotation | 5 | TYR A 34ASN A 590LEU A 114PHE A 85ILE A 119 | None | 1.33A | 5dv4A-5oynA:undetectable | 5dv4A-5oynA:10.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uq6 | TARTRATE-RESISTANTACID PHOSPHATASETYPE 5 (Sus scrofa) |
PF00149(Metallophos) | 5 | HIS A 92PRO A 153ASP A 52ASN A 91HIS A 223 | PO4 A 404 (-3.7A)None FE A 403 ( 2.7A)PO4 A 404 ( 2.6A) FE A 402 (-3.4A) | 1.26A | 5dv4A-5uq6A:4.0 | 5dv4A-5uq6A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uvg | SPHINGOMYELINPHOSPHODIESTERASE3,SPHINGOMYELINPHOSPHODIESTERASE 3 (Homo sapiens) |
no annotation | 5 | HIS A 461ASP A 510ASN A 512ILE A 606HIS A 639 | None | 0.24A | 5dv4A-5uvgA:21.0 | 5dv4A-5uvgA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vbn | DNA POLYMERASEEPSILON SUBUNIT 2 (Homo sapiens) |
PF04042(DNA_pol_E_B)PF12213(Dpoe2NT) | 5 | ASN A 324PRO A 402ASP A 482LEU A 478ILE A 480 | None | 1.11A | 5dv4A-5vbnA:2.0 | 5dv4A-5vbnA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6da0 | GLUCOKINASE (Naegleriafowleri) |
no annotation | 5 | LEU A 319ASN A 155LEU A 194PHE A 337ILE A 164 | NoneBGC A 500 (-3.4A)NoneNoneNone | 1.25A | 5dv4A-6da0A:undetectable | 5dv4A-6da0A:10.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | PROTEIN CFT1 (Saccharomycescerevisiae) |
no annotation | 6 | LEU A 772PRO A 696ASP A 676LEU A 669PHE A 734ILE A 677 | None | 1.48A | 5dv4A-6eojA:undetectable | 5dv4A-6eojA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eom | MUTT/NUDIX FAMILYPROTEIN (Caldithrixabyssi) |
no annotation | 5 | LEU A 351HIS A 460ASN A 464LEU A 471HIS A 375 | None | 1.35A | 5dv4A-6eomA:undetectable | 5dv4A-6eomA:10.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fi2 | VEXL (Achromobacterdenitrificans) |
no annotation | 5 | TYR A 363PRO A 234ASN A 224LEU A 174ILE A 185 | None | 1.41A | 5dv4A-6fi2A:undetectable | 5dv4A-6fi2A:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fqc | BIFUNCTIONALARGININE DEMETHYLASEANDLYSYL-HYDROXYLASEJMJD6 (Homo sapiens) |
no annotation | 5 | TYR A 131PRO A 171ASP A 189ASN A 287HIS A 187 | NoneNone MN A 501 ( 2.6A)OGA A 506 ( 4.6A) MN A 501 ( 3.4A) | 1.38A | 5dv4A-6fqcA:undetectable | 5dv4A-6fqcA:12.70 |