SIMILAR PATTERNS OF AMINO ACIDS FOR 5DV4_A_NMYA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		5 TYR A 199
ASN A 283
HIS A 277
LEU A 376
ILE A 262
 None
 1.26A 5dv4A-1cs1A:
undetectable		 5dv4A-1cs1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		5 LEU A  33
PRO A  83
LEU A 102
PHE A  29
ILE A  45
 None
 1.47A 5dv4A-1esoA:
undetectable		 5dv4A-1esoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fml RETINOL DEHYDRATASE

(Spodoptera
frugiperda) 		PF00685
(Sulfotransfer_1) 		5 TYR A 182
PRO A 171
ASP A 107
LEU A 150
PHE A  67
 None
 1.40A 5dv4A-1fmlA:
undetectable		 5dv4A-1fmlA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		5 LEU A 113
HIS A 338
PRO A 379
LEU A 346
ILE A 342
 None
 1.25A 5dv4A-1ihpA:
undetectable		 5dv4A-1ihpA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq0 METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 LEU A 447
PRO A 220
ASP A 262
ILE A 338
HIS A 331
 None
None
ZN  A 479 (-2.2A)
MED  A 601 ( 4.7A)
ZN  A 480 ( 3.4A)
 1.39A 5dv4A-1kq0A:
undetectable		 5dv4A-1kq0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		5 LEU A 139
ASN A 415
LEU A 296
PHE A 239
ILE A 175
 None
 1.27A 5dv4A-1l1lA:
undetectable		 5dv4A-1l1lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LEU A   6
LEU A  89
PHE A 192
ILE A  93
HIS A  97
 None
 1.36A 5dv4A-1mwoA:
undetectable		 5dv4A-1mwoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)

(Caenorhabditis
elegans) 		PF01633
(Choline_kinase) 		5 ASN A 115
HIS A 121
LEU A 132
PHE A 251
ILE A 128
 None
 1.30A 5dv4A-1nw1A:
undetectable		 5dv4A-1nw1A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmi PHOSPHOMANNOSE
ISOMERASE

(Candida
albicans) 		PF01238
(PMI_typeI) 		5 LEU A 279
ASN A 272
LEU A 245
PHE A 149
ILE A 288
 None
 1.43A 5dv4A-1pmiA:
undetectable		 5dv4A-1pmiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 TYR A 562
ASP A 424
LEU A 607
PHE A 583
ILE A 427
 None
 1.14A 5dv4A-1t1uA:
undetectable		 5dv4A-1t1uA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae) 		PF13277
(YmdB) 		5 HIS A 185
ASP A  12
ASN A  44
LEU A  51
HIS A 158
 FE  A 301 (-3.5A)
FE  A 301 (-3.2A)
FE  A 301 (-2.7A)
None
FE  A 302 (-3.5A)
 1.32A 5dv4A-1t71A:
5.0		 5dv4A-1t71A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae) 		PF13277
(YmdB) 		5 LEU A 130
HIS A 185
ASP A  12
ASN A  44
LEU A  51
 None
FE  A 301 (-3.5A)
FE  A 301 (-3.2A)
FE  A 301 (-2.7A)
None
 1.45A 5dv4A-1t71A:
5.0		 5dv4A-1t71A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		5 TYR A  34
HIS A 183
PRO A 262
ASP A 180
ASN A 217
 None
ZN  A 302 (-3.2A)
None
ZN  A 303 ( 3.3A)
None
 1.38A 5dv4A-1xp3A:
undetectable		 5dv4A-1xp3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		5 HIS A 728
ASP A 769
LEU A 761
PHE A 581
ILE A 765
 None
 1.43A 5dv4A-1ygpA:
undetectable		 5dv4A-1ygpA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx1 HYPOTHETICAL PROTEIN
PA2260

(Pseudomonas
aeruginosa) 		PF01261
(AP_endonuc_2) 		5 LEU A  44
ASN A 164
HIS A 187
PRO A 230
ILE A 227
 None
 1.36A 5dv4A-1yx1A:
undetectable		 5dv4A-1yx1A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr5 H2AFY PROTEIN

(Homo sapiens) 		PF01661
(Macro) 		5 LEU A 205
ASN A 317
LEU A 329
PHE A 349
ILE A 328
 None
 1.44A 5dv4A-1zr5A:
undetectable		 5dv4A-1zr5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		5 TYR A 273
HIS A 185
ASP A 229
ASN A 231
HIS A 325
 None
None
None
PO4  A 401 ( 4.3A)
PO4  A 401 (-3.8A)
 1.02A 5dv4A-1zwxA:
19.7		 5dv4A-1zwxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		5 HIS A 235
ASP A 191
LEU A 176
ILE A 190
HIS A 104
 ZN  A 251 (-3.3A)
ZN  A 251 ( 2.4A)
None
None
ZN  A 252 (-3.3A)
 1.15A 5dv4A-2a7mA:
undetectable		 5dv4A-2a7mA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adu METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 LEU A 447
PRO A 220
ASP A 262
ILE A 338
HIS A 331
 None
None
CO  A 501 (-2.2A)
R20  A 906 ( 4.5A)
CO  A 502 ( 3.2A)
 1.39A 5dv4A-2aduA:
undetectable		 5dv4A-2aduA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904

(Enterococcus
faecalis) 		PF12706
(Lactamase_B_2) 		5 HIS A  97
ASP A  96
LEU A 406
PHE A 222
ILE A  18
 ZN  A 602 (-3.3A)
ZN  A 602 (-2.8A)
None
None
None
 1.45A 5dv4A-2az4A:
2.5		 5dv4A-2az4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0z NOVW

(Streptomyces
niveus) 		PF00908
(dTDP_sugar_isom) 		5 LEU A 130
TYR A 132
ASP A 168
LEU A 153
HIS A  62
 None
None
SO4  A1191 ( 4.3A)
None
None
 1.08A 5dv4A-2c0zA:
undetectable		 5dv4A-2c0zA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewo PUTATIVE AGMATINE
DEIMINASE

(Streptococcus
mutans) 		PF04371
(PAD_porph) 		5 LEU A 160
ASN A 310
HIS A 360
LEU A  30
ILE A  98
 None
 1.10A 5dv4A-2ewoA:
undetectable		 5dv4A-2ewoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE

(Homo sapiens) 		PF00755
(Carn_acyltransf) 		5 TYR A 552
ASP A 414
LEU A 597
PHE A 573
ILE A 417
 None
 1.14A 5dv4A-2fy2A:
undetectable		 5dv4A-2fy2A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcu PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 3

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B) 		5 ASN A 243
HIS A  74
ASP A  45
LEU A  42
ILE A  44
 None
 1.27A 5dv4A-2gcuA:
undetectable		 5dv4A-2gcuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		5 TYR A 365
PRO A  92
ASP A 210
LEU A 123
HIS A 214
 None
None
ZN  A1001 (-2.0A)
None
ZN  A1001 (-3.2A)
 1.27A 5dv4A-2gsnA:
undetectable		 5dv4A-2gsnA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibn INOSITOL OXYGENASE

(Homo sapiens) 		PF05153
(MIOX) 		5 LEU A 254
HIS A 194
PRO A 224
ASP A 195
LEU A 185
 None
FE  A 704 ( 3.5A)
None
I1N  A 710 ( 4.8A)
None
 1.40A 5dv4A-2ibnA:
undetectable		 5dv4A-2ibnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5f PUTATIVE NUDIX
HYDROLASE DR_0079

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		5 PRO A 101
ASP A  95
LEU A 121
PHE A  82
ILE A  94
 None
 1.37A 5dv4A-2o5fA:
undetectable		 5dv4A-2o5fA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 LEU A 201
LEU A  71
PHE A 174
ILE A  75
HIS A  79
 None
 1.24A 5dv4A-2qpsA:
undetectable		 5dv4A-2qpsA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0h CGL3 LECTIN

(Coprinopsis
cinerea) 		PF00337
(Gal-bind_lectin) 		5 LEU A   5
HIS A  60
PRO A 143
PHE A 145
ILE A  63
 None
CTO  A 165 (-3.6A)
None
None
None
 1.42A 5dv4A-2r0hA:
undetectable		 5dv4A-2r0hA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		5 LEU A 201
ASN A 346
HIS A 345
PHE A 194
ILE A 488
 None
 1.43A 5dv4A-2rchA:
undetectable		 5dv4A-2rchA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		5 LEU A 118
ASN A  83
LEU A  95
PHE A 147
ILE A  86
 None
 1.27A 5dv4A-2x2uA:
undetectable		 5dv4A-2x2uA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 TYR A 271
ASN A 431
LEU A 400
PHE A 415
ILE A 424
 None
 1.46A 5dv4A-2x7jA:
undetectable		 5dv4A-2x7jA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASN A 110
ASP A 143
LEU A 281
PHE A 315
ILE A 287
 None
 1.05A 5dv4A-3czmA:
undetectable		 5dv4A-3czmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi9 MALATE DEHYDROGENASE

(Porphyromonas
gingivalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASP A 288
ASN A 290
LEU A 301
PHE A 268
ILE A 289
 None
 1.38A 5dv4A-3fi9A:
undetectable		 5dv4A-3fi9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		5 LEU A 327
PRO A  98
ASP A 141
ILE A 217
HIS A 210
 None
None
FE  A 452 ( 2.2A)
FUG  A 481 (-4.5A)
FE  A 451 (-3.4A)
 1.45A 5dv4A-3fmqA:
undetectable		 5dv4A-3fmqA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6s PUTATIVE
ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
FAMILY PROTEIN

(Bacteroides
vulgatus) 		PF03372
(Exo_endo_phos) 		5 HIS A 138
ASP A 172
ASN A 174
ILE A 223
HIS A 251
 None
 0.33A 5dv4A-3g6sA:
27.3		 5dv4A-3g6sA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gip N-ACYL-D-GLUTAMATE
DEACYLASE

(Bordetella
bronchiseptica) 		PF07969
(Amidohydro_3) 		5 LEU A 407
ASP A 268
LEU A 234
ILE A 267
HIS A 357
 None
 1.45A 5dv4A-3gipA:
undetectable		 5dv4A-3gipA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		5 LEU A 211
HIS A 377
PRO A 204
ASP A 336
LEU A 361
 None
 1.39A 5dv4A-3h2iA:
undetectable		 5dv4A-3h2iA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		5 LEU A  36
ASN A 218
PRO A 297
ASN A 244
ILE A 388
 None
 1.42A 5dv4A-3i16A:
undetectable		 5dv4A-3i16A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky8 PUTATIVE RIBOFLAVIN
BIOSYNTHESIS PROTEIN

(Shewanella
loihica) 		PF01872
(RibD_C) 		5 LEU A  41
ASN A 104
ASN A   3
LEU A 123
ILE A 128
 None
 1.40A 5dv4A-3ky8A:
undetectable		 5dv4A-3ky8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1w UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF03372
(Exo_endo_phos) 		5 HIS A 132
ASP A 166
ASN A 168
ILE A 214
HIS A 242
 None
 0.23A 5dv4A-3l1wA:
25.9		 5dv4A-3l1wA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 TYR B 159
ASN B 105
LEU B 103
PHE B  56
ILE B 104
 None
 1.16A 5dv4A-3mm5B:
undetectable		 5dv4A-3mm5B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfz ASPARTOACYLASE-2

(Mus musculus) 		PF04952
(AstE_AspA) 		5 LEU A 100
HIS A 116
LEU A 138
PHE A 111
ILE A 174
 None
ZN  A 319 (-3.4A)
None
None
None
 1.11A 5dv4A-3nfzA:
undetectable		 5dv4A-3nfzA:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		12 LEU A 206
TYR A 207
ASN A 325
HIS A 360
PRO A 365
LYS A 371
ASP A 410
ASN A 412
LEU A 414
PHE A 484
ILE A 488
HIS A 529
 None
None
None
None
None
None
MG  A 556 (-2.8A)
MG  A 556 (-3.2A)
None
None
None
MG  A 556 (-4.2A)
 0.32A 5dv4A-3ngoA:
57.3		 5dv4A-3ngoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		6 TYR A 207
ASP A 489
LEU A 414
PHE A 484
ILE A 488
HIS A 529
 None
None
None
None
None
MG  A 556 (-4.2A)
 1.25A 5dv4A-3ngoA:
57.3		 5dv4A-3ngoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASN A 110
ASP A 143
LEU A 281
PHE A 315
ILE A 287
 None
 1.06A 5dv4A-3om9A:
undetectable		 5dv4A-3om9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		5 TYR A 605
ASN A 439
ASP A 657
LEU A 620
PHE A 548
 None
 1.37A 5dv4A-3qcwA:
undetectable		 5dv4A-3qcwA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 391
ASN A 462
ASP A 531
ILE A 457
HIS A 452
 None
 1.21A 5dv4A-3s95A:
undetectable		 5dv4A-3s95A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU C 959
TYR C 947
ASN C1145
PHE C 883
ILE C 714
 None
 1.48A 5dv4A-3sr6C:
undetectable		 5dv4A-3sr6C:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 143
PRO A 338
ASN A 326
LEU A 309
ILE A 325
 None
 1.47A 5dv4A-3sszA:
undetectable		 5dv4A-3sszA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA

(Pyrococcus
furiosus) 		PF09376
(NurA) 		5 LEU A 133
ASN A 147
LEU A 166
PHE A 355
ILE A 277
 None
 1.33A 5dv4A-3talA:
undetectable		 5dv4A-3talA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Enterobacter
sp. 638) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASN A  75
ASP A  94
LEU A 323
PHE A 113
ILE A 287
 None
 1.38A 5dv4A-3tjiA:
undetectable		 5dv4A-3tjiA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tni CYCLIN-T1

(Homo sapiens) 		PF00134
(Cyclin_N) 		5 LEU B 184
HIS B 154
ASN B  60
LEU B  88
ILE B  59
 None
 1.43A 5dv4A-3tniB:
undetectable		 5dv4A-3tniB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqx 2-AMINO-3-KETOBUTYRA
TE COENZYME A LIGASE

(Coxiella
burnetii) 		PF00155
(Aminotran_1_2) 		5 ASN A 153
ASP A 179
ASN A 133
PHE A 117
ILE A 137
 None
PLP  A 397 ( 4.1A)
None
None
None
 1.37A 5dv4A-3tqxA:
undetectable		 5dv4A-3tqxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uo2 J-TYPE CO-CHAPERONE
JAC1, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00226
(DnaJ)
PF07743
(HSCB_C) 		5 ASN A 147
PRO A  27
LEU A  69
PHE A  22
ILE A  31
 None
 1.40A 5dv4A-3uo2A:
undetectable		 5dv4A-3uo2A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		5 LEU A  49
ASN A 375
LEU A  10
PHE A  56
ILE A  14
 None
 1.24A 5dv4A-3vw5A:
undetectable		 5dv4A-3vw5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9u PUTATIVE LIPASE

(Proteus
mirabilis) 		PF00561
(Abhydrolase_1) 		5 ASN A 210
HIS A 216
ASP A 253
PHE A 143
ILE A 255
 None
 1.49A 5dv4A-3w9uA:
undetectable		 5dv4A-3w9uA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1o ROQUIN-1

(Homo sapiens) 		no annotation 5 LEU A 204
TYR A 276
LEU A 324
ILE A 320
HIS A 316
 None
 1.14A 5dv4A-3x1oA:
undetectable		 5dv4A-3x1oA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 ASN A 492
HIS A 491
ASP A 535
LEU A  72
ILE A 538
 None
 1.39A 5dv4A-3ziuA:
undetectable		 5dv4A-3ziuA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF13277
(YmdB) 		5 HIS A 177
ASP A   8
ASN A  40
LEU A  47
HIS A 150
 FE2  A1266 ( 3.3A)
FE2  A1266 (-3.1A)
FE2  A1266 ( 2.5A)
None
FE2  A1267 (-3.3A)
 1.27A 5dv4A-4b2oA:
5.1		 5dv4A-4b2oA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		5 TYR A 327
ASN A 135
HIS A 374
LEU A 207
ILE A 376
 None
 1.34A 5dv4A-4bxwA:
undetectable		 5dv4A-4bxwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		5 ASN A 303
PRO A  77
ASP A  40
ASN A 289
HIS A 236
 None
None
CA  A 603 (-3.0A)
CA  A 603 (-2.9A)
NGA  A 604 (-3.3A)
 1.42A 5dv4A-4fdjA:
undetectable		 5dv4A-4fdjA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl4 TBC1 DOMAIN FAMILY
MEMBER 20

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 HIS A 227
ASP A 148
LEU A 155
PHE A 110
HIS A 147
 None
 1.29A 5dv4A-4hl4A:
undetectable		 5dv4A-4hl4A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU A 354
ASN A 398
LEU A 339
PHE A 360
ILE A 367
 None
 1.48A 5dv4A-4k17A:
undetectable		 5dv4A-4k17A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjr CATION EXCHANGER
YFKE

(Bacillus
subtilis) 		PF01699
(Na_Ca_ex) 		5 LEU A 174
HIS A 256
ASN A  69
LEU A  92
ILE A 282
 None
 1.45A 5dv4A-4kjrA:
undetectable		 5dv4A-4kjrA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 424
ASN A 316
LEU A 328
PHE A 363
ILE A 324
 None
 1.14A 5dv4A-4mz0A:
undetectable		 5dv4A-4mz0A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntl LIPOPROTEIN, YAEC
FAMILY

(Enterococcus
faecalis) 		PF03180
(Lipoprotein_9) 		5 LEU A 206
PRO A 136
LEU A 149
PHE A 116
ILE A 148
 None
 1.48A 5dv4A-4ntlA:
undetectable		 5dv4A-4ntlA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qik ROQUIN-1

(Homo sapiens) 		no annotation 5 LEU A 204
TYR A 276
LEU A 324
ILE A 320
HIS A 316
 None
 1.16A 5dv4A-4qikA:
undetectable		 5dv4A-4qikA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 841
ASN A 922
ASP A 987
ILE A 914
HIS A 909
 None
MG  A1502 ( 2.6A)
None
None
None
 1.38A 5dv4A-4qpmA:
undetectable		 5dv4A-4qpmA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2h STIV B204 ATPASE

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 ASP A  39
LEU A 133
PHE A 109
ILE A 102
HIS A  41
 ZN  A 300 (-2.1A)
None
None
None
ZN  A 300 (-3.0A)
 1.41A 5dv4A-4r2hA:
undetectable		 5dv4A-4r2hA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Beutenbergia
cavernae) 		PF03372
(Exo_endo_phos) 		5 HIS A 197
ASP A 232
ASN A 234
ILE A 292
HIS A 318
 None
 0.20A 5dv4A-4ruwA:
23.9		 5dv4A-4ruwA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		5 LEU A 118
ASN A  83
LEU A  95
PHE A 147
ILE A  86
 None
 1.26A 5dv4A-4ux8A:
undetectable		 5dv4A-4ux8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		5 TYR A 334
ASN A  73
HIS A 119
ASP A 130
HIS A 176
 None
 1.24A 5dv4A-4wu0A:
undetectable		 5dv4A-4wu0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		8 LEU A 317
TYR A 318
HIS A 456
PRO A 461
ASP A 496
ASN A 498
PHE A 556
HIS A 599
 None
None
None
GOL  A 706 (-3.9A)
None
GOL  A 706 (-4.8A)
GOL  A 706 ( 4.7A)
None
 0.64A 5dv4A-4z0vA:
39.5		 5dv4A-4z0vA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z31 ROQUIN-2

(Homo sapiens) 		no annotation 5 LEU A 201
TYR A 273
LEU A 321
ILE A 317
HIS A 313
 None
 1.13A 5dv4A-4z31A:
undetectable		 5dv4A-4z31A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4l CELLOBIOSE
2-EPIMERASE

(Caldicellulosiruptor
saccharolyticus) 		PF07221
(GlcNAc_2-epim) 		5 LEU A  53
ASN A 378
LEU A  14
PHE A  60
ILE A  18
 None
 1.21A 5dv4A-4z4lA:
undetectable		 5dv4A-4z4lA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a52 CALCIUM-DEPENDENT
LIPID-BINDING
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00168
(C2) 		5 LEU A 145
ASN A  53
LEU A   8
PHE A  88
ILE A  10
 None
 1.35A 5dv4A-5a52A:
undetectable		 5dv4A-5a52A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aho 5' EXONUCLEASE
APOLLO

(Homo sapiens) 		PF07522
(DRMBL) 		5 ASN A 148
HIS A 276
ASP A 120
ILE A 297
HIS A  36
 None
TLA  A1319 ( 3.9A)
ZN  A1320 (-2.5A)
None
ZN  A1320 ( 3.4A)
 1.31A 5dv4A-5ahoA:
undetectable		 5dv4A-5ahoA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5f ROQUIN-1

(Mus musculus) 		no annotation 5 LEU A 204
TYR A 276
LEU A 324
ILE A 320
HIS A 316
 None
 1.17A 5dv4A-5f5fA:
undetectable		 5dv4A-5f5fA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		5 LEU A 597
HIS A 520
ASN A 426
LEU A 439
PHE A 615
 None
 1.37A 5dv4A-5gggA:
2.3		 5dv4A-5gggA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h28 OXYSTEROL-BINDING
PROTEIN HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF13637
(Ank_4) 		5 PRO A 223
ASP A 188
ASN A 190
LEU A 216
ILE A 189
 None
 1.41A 5dv4A-5h28A:
undetectable		 5dv4A-5h28A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Paraburkholderia
graminis) 		PF13407
(Peripla_BP_4) 		5 LEU A 251
ASN A  95
ASP A 118
ASN A 166
PHE A 248
 None
None
64K  A 401 (-2.7A)
64K  A 401 (-2.6A)
64K  A 401 ( 4.9A)
 1.36A 5dv4A-5hqjA:
undetectable		 5dv4A-5hqjA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		5 HIS A 206
ASP A 276
LEU A 339
PHE A 325
HIS A 423
 ZN  A 701 ( 3.3A)
ZN  A 702 (-2.3A)
None
None
ZN  A 702 (-3.2A)
 1.39A 5dv4A-5hqnA:
4.3		 5dv4A-5hqnA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		5 HIS A 208
ASP A 278
LEU A 341
PHE A 327
HIS A 425
 ZN  A 715 ( 3.4A)
ZN  A 714 (-2.6A)
None
None
ZN  A 714 (-3.2A)
 1.34A 5dv4A-5i85A:
4.3		 5dv4A-5i85A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 5 ASN A 140
HIS A 143
LEU A 127
PHE A 101
ILE A 114
 None
 1.46A 5dv4A-5jnmA:
undetectable		 5dv4A-5jnmA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp6 PUTATIVE
POLYSACCHARIDE
DEACETYLASE

(Bdellovibrio
bacteriovorus) 		PF01522
(Polysacc_deac_1) 		5 ASN A  95
PRO A 179
LEU A 188
PHE A 200
ILE A 187
 None
 1.27A 5dv4A-5jp6A:
undetectable		 5dv4A-5jp6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ASN A1014
ASP A1068
LEU A1041
ILE A1006
HIS A 998
 ATP  A1200 (-3.6A)
None
SEP  A1042 ( 3.7A)
None
None
 1.44A 5dv4A-5lpyA:
undetectable		 5dv4A-5lpyA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ASN A1014
ASP A1068
LEU A1041
ILE A1006
HIS A 998
 ADP  A1200 (-3.6A)
None
SEP  A1042 ( 3.7A)
None
None
 1.42A 5dv4A-5lpzA:
undetectable		 5dv4A-5lpzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE

(Escherichia
coli) 		PF01977
(UbiD) 		5 LEU A  22
LEU A 229
PHE A  67
ILE A 228
HIS A 318
 None
 1.37A 5dv4A-5m1bA:
undetectable		 5dv4A-5m1bA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mf1 FUSION PROTEIN
HAP2/GCS1

(Chlamydomonas
reinhardtii) 		PF10699
(HAP2-GCS1) 		5 HIS A 287
PRO A 293
LEU A 306
PHE A 230
ILE A 232
 None
 1.29A 5dv4A-5mf1A:
undetectable		 5dv4A-5mf1A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms7 LEGIONELLA
PNEUMOPHILA EFFECTOR
PROTEIN RAVZ

(Legionella
pneumophila) 		no annotation 5 LEU A  68
ASP A 197
LEU A 224
PHE A 163
HIS A 176
 None
 1.32A 5dv4A-5ms7A:
undetectable		 5dv4A-5ms7A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 TYR A  34
ASN A 590
LEU A 114
PHE A  85
ILE A 119
 None
 1.33A 5dv4A-5oynA:
undetectable		 5dv4A-5oynA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		5 HIS A  92
PRO A 153
ASP A  52
ASN A  91
HIS A 223
 PO4  A 404 (-3.7A)
None
FE  A 403 ( 2.7A)
PO4  A 404 ( 2.6A)
FE  A 402 (-3.4A)
 1.26A 5dv4A-5uq6A:
4.0		 5dv4A-5uq6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3

(Homo sapiens) 		no annotation 5 HIS A 461
ASP A 510
ASN A 512
ILE A 606
HIS A 639
 None
 0.24A 5dv4A-5uvgA:
21.0		 5dv4A-5uvgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbn DNA POLYMERASE
EPSILON SUBUNIT 2

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF12213
(Dpoe2NT) 		5 ASN A 324
PRO A 402
ASP A 482
LEU A 478
ILE A 480
 None
 1.11A 5dv4A-5vbnA:
2.0		 5dv4A-5vbnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6da0 GLUCOKINASE

(Naegleria
fowleri) 		no annotation 5 LEU A 319
ASN A 155
LEU A 194
PHE A 337
ILE A 164
 None
BGC  A 500 (-3.4A)
None
None
None
 1.25A 5dv4A-6da0A:
undetectable		 5dv4A-6da0A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 6 LEU A 772
PRO A 696
ASP A 676
LEU A 669
PHE A 734
ILE A 677
 None
 1.48A 5dv4A-6eojA:
undetectable		 5dv4A-6eojA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eom MUTT/NUDIX FAMILY
PROTEIN

(Caldithrix
abyssi) 		no annotation 5 LEU A 351
HIS A 460
ASN A 464
LEU A 471
HIS A 375
 None
 1.35A 5dv4A-6eomA:
undetectable		 5dv4A-6eomA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fi2 VEXL

(Achromobacter
denitrificans) 		no annotation 5 TYR A 363
PRO A 234
ASN A 224
LEU A 174
ILE A 185
 None
 1.41A 5dv4A-6fi2A:
undetectable		 5dv4A-6fi2A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo sapiens) 		no annotation 5 TYR A 131
PRO A 171
ASP A 189
ASN A 287
HIS A 187
 None
None
MN  A 501 ( 2.6A)
OGA  A 506 ( 4.6A)
MN  A 501 ( 3.4A)
 1.38A 5dv4A-6fqcA:
undetectable		 5dv4A-6fqcA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpo PROTEIN (CLATHRIN)

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link)
PF13838
(Clathrin_H_link) 		3 GLU A 133
TRP A 130
ASN A  74
 None
 1.11A 5dv4A-1bpoA:
undetectable		 5dv4A-1bpoA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		3 GLU A 769
TRP A 726
ASN A 706
 None
 1.15A 5dv4A-1c7tA:
1.3		 5dv4A-1c7tA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpy SERINE
CARBOXYPEPTIDASE

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		3 GLU A 198
TRP A 343
ASN A 394
 None
 1.15A 5dv4A-1cpyA:
0.0		 5dv4A-1cpyA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gp1 GLUTATHIONE
PEROXIDASE

(Bos taurus) 		PF00255
(GSHPx) 		3 GLU A 161
TRP A 158
ASN A 114
 None
SE7  A  45 ( 4.4A)
None
 1.00A 5dv4A-1gp1A:
undetectable		 5dv4A-1gp1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 GLU A 446
TRP A 489
ASN A 492
 None
R03  A 800 (-4.7A)
None
 0.70A 5dv4A-1h39A:
undetectable		 5dv4A-1h39A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		3 GLU A 125
TRP A 162
ASN A 250
 ZN  A 401 ( 2.5A)
None
CIL  A 451 ( 4.7A)
 0.58A 5dv4A-1ituA:
0.6		 5dv4A-1ituA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 GLU X 208
TRP X 173
ASN X 245
 None
 0.91A 5dv4A-1js1X:
undetectable		 5dv4A-1js1X:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 GLU A  11
TRP A 211
ASN A  92
 None
 0.67A 5dv4A-1kcwA:
1.2		 5dv4A-1kcwA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 GLU A 721
TRP A 910
ASN A 807
 None
 0.82A 5dv4A-1kcwA:
1.2		 5dv4A-1kcwA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m32 2-AMINOETHYLPHOSPHON
ATE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		3 GLU A  40
TRP A 229
ASN A 235
 None
 1.13A 5dv4A-1m32A:
0.0		 5dv4A-1m32A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ncb IGG2A-KAPPA NC41 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLU H  96
TRP H  50
ASN H  31
 None
 0.92A 5dv4A-1ncbH:
undetectable		 5dv4A-1ncbH:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		3 GLU A  82
TRP A  83
ASN A 148
 None
 0.75A 5dv4A-1qvbA:
undetectable		 5dv4A-1qvbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r77 CELL WALL TARGETING
DOMAIN OF
GLYCYLGLYCINE
ENDOPEPTIDASE ALE-1

(Staphylococcus
capitis) 		PF08460
(SH3_5) 		3 GLU A 320
TRP A 329
ASN A 274
 None
 1.15A 5dv4A-1r77A:
undetectable		 5dv4A-1r77A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s14 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF02518
(HATPase_c) 		3 GLU A1171
TRP A1168
ASN A1143
 None
 1.06A 5dv4A-1s14A:
undetectable		 5dv4A-1s14A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s16 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		3 GLU A1171
TRP A1168
ASN A1143
 None
 1.09A 5dv4A-1s16A:
undetectable		 5dv4A-1s16A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		3 GLU A  83
TRP A  84
ASN A 147
 None
 0.70A 5dv4A-1uwiA:
undetectable		 5dv4A-1uwiA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 GLU A2313
TRP A2376
ASN A2372
 None
None
PO4  A3480 (-2.8A)
 1.06A 5dv4A-1wchA:
undetectable		 5dv4A-1wchA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 GLU A 822
TRP A 828
ASN A 742
 None
 1.14A 5dv4A-1wz2A:
undetectable		 5dv4A-1wz2A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10) 		3 GLU A 639
TRP A 640
ASN A 687
 None
 1.13A 5dv4A-1xyzA:
undetectable		 5dv4A-1xyzA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 GLU A 304
TRP A 307
ASN A 502
 None
 1.13A 5dv4A-2aeyA:
undetectable		 5dv4A-2aeyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlw DOCKING PROTEIN 2,
ISOFORM A

(Homo sapiens) 		PF02174
(IRS) 		3 GLU A  81
TRP A  54
ASN A  83
 None
 1.15A 5dv4A-2dlwA:
undetectable		 5dv4A-2dlwA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dxb THIOCYANATE
HYDROLASE SUBUNIT
GAMMA

(Thiobacillus
thioparus) 		PF02979
(NHase_alpha) 		3 GLU C 165
TRP C 158
ASN C 150
 None
 1.15A 5dv4A-2dxbC:
undetectable		 5dv4A-2dxbC:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej4 ZINC FINGER PROTEIN
ZIC 3

(Homo sapiens) 		PF00096
(zf-C2H2) 		3 GLU A  21
TRP A  18
ASN A  57
 None
 1.14A 5dv4A-2ej4A:
undetectable		 5dv4A-2ej4A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8a GLUTATHIONE
PEROXIDASE 1

(Homo sapiens) 		PF00255
(GSHPx) 		3 GLU A 163
TRP A 160
ASN A 116
 None
MLA  A 501 (-4.1A)
None
 1.01A 5dv4A-2f8aA:
undetectable		 5dv4A-2f8aA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 GLU A1041
TRP A1100
ASN A1096
 None
 1.13A 5dv4A-2gjtA:
undetectable		 5dv4A-2gjtA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he3 GLUTATHIONE
PEROXIDASE 2

(Homo sapiens) 		PF00255
(GSHPx) 		3 GLU A 155
TRP A 152
ASN A 108
 None
 1.02A 5dv4A-2he3A:
undetectable		 5dv4A-2he3A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3y EPIDIDYMAL SECRETORY
GLUTATHIONE
PEROXIDASE

(Homo sapiens) 		PF00255
(GSHPx) 		3 GLU A 184
TRP A 181
ASN A 141
 None
EDO  A 221 ( 3.7A)
None
 0.88A 5dv4A-2i3yA:
undetectable		 5dv4A-2i3yA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nna MHC CLASS II ANTIGEN

(Homo sapiens) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		3 GLU B 187
TRP B 188
ASN B 134
 None
 1.09A 5dv4A-2nnaB:
undetectable		 5dv4A-2nnaB:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U BETA
CHAIN

(Mus musculus) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		3 GLU B 287
TRP B 288
ASN B 234
 None
 1.05A 5dv4A-2p24B:
undetectable		 5dv4A-2p24B:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r37 GLUTATHIONE
PEROXIDASE 3

(Homo sapiens) 		PF00255
(GSHPx) 		3 GLU A 184
TRP A 181
ASN A 141
 None
CL  A   1 (-4.7A)
None
 0.83A 5dv4A-2r37A:
undetectable		 5dv4A-2r37A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2sas SARCOPLASMIC
CALCIUM-BINDING
PROTEIN

(Branchiostoma
lanceolatum) 		PF13833
(EF-hand_8) 		3 GLU A  32
TRP A  62
ASN A  21
 None
None
CA  A 186 ( 2.7A)
 1.11A 5dv4A-2sasA:
undetectable		 5dv4A-2sasA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywa HYPOTHETICAL PROTEIN
TTHA0048

(Thermus
thermophilus) 		PF08780
(NTase_sub_bind) 		3 GLU A  32
TRP A  39
ASN A  83
 None
 1.07A 5dv4A-2ywaA:
undetectable		 5dv4A-2ywaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj9 AMPC

(Escherichia
coli) 		PF00144
(Beta-lactamase) 		3 GLU A 272
TRP A 312
ASN A 346
 IPA  A 362 (-4.3A)
None
None
 0.98A 5dv4A-2zj9A:
undetectable		 5dv4A-2zj9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 GLU A 800
TRP A 823
ASN A 720
 None
MPD  A1696 (-4.1A)
None
 0.80A 5dv4A-2zxqA:
undetectable		 5dv4A-2zxqA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akz GLUTAMYL-TRNA
SYNTHETASE 2

(Thermotoga
maritima) 		no annotation 3 GLU B 339
TRP B 343
ASN B 324
 None
 1.04A 5dv4A-3akzB:
undetectable		 5dv4A-3akzB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4u CARBOXYPEPTIDASE B2
CARBOXYPEPTIDASE
INHIBITOR

(Bos taurus;
Rhipicephalus
bursa) 		PF00246
(Peptidase_M14)
PF10468
(Inhibitor_I68) 		3 GLU A  72
TRP B  73
ASN A 144
 ZN  A 309 (-2.1A)
None
ACT  A 601 (-3.8A)
 1.02A 5dv4A-3d4uA:
undetectable		 5dv4A-3d4uA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv5 DNA TOPOISOMERASE 4
SUBUNIT B

(Escherichia
coli) 		PF02518
(HATPase_c) 		3 GLU A 171
TRP A 168
ASN A 143
 None
 1.04A 5dv4A-3fv5A:
undetectable		 5dv4A-3fv5A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Methylobacillus
flagellatus) 		PF13460
(NAD_binding_10) 		3 GLU A 116
TRP A 118
ASN A 244
 None
None
EDO  A 286 (-3.3A)
 1.16A 5dv4A-3gpiA:
undetectable		 5dv4A-3gpiA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		3 GLU A 468
TRP A 466
ASN A 461
 None
None
ACT  A   8 (-3.6A)
 1.06A 5dv4A-3gzsA:
undetectable		 5dv4A-3gzsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
13
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'

(Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF12136
(RNA_pol_Rpo13) 		3 GLU Y  76
TRP A 125
ASN A 119
 None
 1.14A 5dv4A-3hkzY:
undetectable		 5dv4A-3hkzY:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7u AP4A HYDROLASE

(Aquifex
aeolicus) 		PF00293
(NUDIX) 		3 GLU A  51
TRP A  96
ASN A  33
 None
None
CL  A 148 ( 4.4A)
 1.10A 5dv4A-3i7uA:
undetectable		 5dv4A-3i7uA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 GLU A  37
TRP A  38
ASN A  25
 None
ACO  A 401 (-3.6A)
None
 1.14A 5dv4A-3il4A:
undetectable		 5dv4A-3il4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 GLU A 337
TRP A  44
ASN A 376
 None
 1.05A 5dv4A-3iveA:
5.1		 5dv4A-3iveA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvd TRANSCRIPTIONAL
REGULATORS

(Corynebacterium
glutamicum) 		PF13377
(Peripla_BP_3) 		3 GLU A  81
TRP A 271
ASN A  76
 None
 0.78A 5dv4A-3jvdA:
undetectable		 5dv4A-3jvdA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis) 		PF00463
(ICL) 		3 GLU A 160
TRP A  94
ASN A 101
 None
 1.10A 5dv4A-3lg3A:
undetectable		 5dv4A-3lg3A:
23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 GLU A 240
TRP A 363
ASN A 479
 MG  A 557 (-2.6A)
None
None
 0.16A 5dv4A-3ngoA:
57.3		 5dv4A-3ngoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE

(Pseudomonas
aeruginosa) 		PF01048
(PNP_UDP_1) 		3 GLU A  41
TRP A  85
ASN A  79
 None
 1.03A 5dv4A-3ozbA:
undetectable		 5dv4A-3ozbA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3t 30S RIBOSOMAL
PROTEIN S6

(Bacillus
anthracis) 		PF01250
(Ribosomal_S6) 		3 GLU A   5
TRP A  43
ASN A  39
 None
 1.14A 5dv4A-3r3tA:
undetectable		 5dv4A-3r3tA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5q PUTATIVE
GLYCOSYLHYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		3 GLU A 103
TRP A 121
ASN A  84
 None
 1.02A 5dv4A-3s5qA:
undetectable		 5dv4A-3s5qA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 283
TRP A 111
ASN A  84
 None
 1.00A 5dv4A-3sjnA:
undetectable		 5dv4A-3sjnA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 GLU A 488
TRP A 522
ASN A 518
 None
 1.00A 5dv4A-3sqgA:
undetectable		 5dv4A-3sqgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		3 GLU A  72
TRP A 252
ASN A 180
 CL  A 807 (-4.5A)
EPE  A 804 (-4.0A)
None
 1.04A 5dv4A-3w5fA:
undetectable		 5dv4A-3w5fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus) 		PF01670
(Glyco_hydro_12) 		3 GLU A 127
TRP A  84
ASN A 136
 BGC  A 413 ( 4.9A)
BGC  A 413 (-3.8A)
BGC  A 412 ( 3.9A)
 1.13A 5dv4A-3wq1A:
undetectable		 5dv4A-3wq1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		3 GLU A  81
TRP A  31
ASN A 206
 None
 1.03A 5dv4A-3wq8A:
undetectable		 5dv4A-3wq8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		3 GLU A  81
TRP A  82
ASN A 147
 None
 0.96A 5dv4A-3wq8A:
undetectable		 5dv4A-3wq8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		3 GLU A 178
TRP A 188
ASN A 174
 NA  A 402 (-2.8A)
None
None
 1.14A 5dv4A-3wsuA:
2.2		 5dv4A-3wsuA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2

(Homo sapiens) 		PF10250
(O-FucT) 		3 GLU A 232
TRP A 234
ASN A 116
 None
 1.05A 5dv4A-4ap5A:
undetectable		 5dv4A-4ap5A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bub UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--LD-LYSINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 GLU A  97
TRP A 100
ASN A   9
 None
 0.95A 5dv4A-4bubA:
undetectable		 5dv4A-4bubA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8p PEPTIDE FROM
GAMMA-GLIADIN,HLA
CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DQ BETA 1
CHAIN

(Homo sapiens;
Triticum
aestivum) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		3 GLU B 187
TRP B 188
ASN B 134
 None
 1.08A 5dv4A-4d8pB:
undetectable		 5dv4A-4d8pB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffy DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (HEAVY
CHAIN)
DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (LIGHT
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		3 GLU H  46
TRP H  47
ASN L   1
 None
 1.15A 5dv4A-4ffyH:
undetectable		 5dv4A-4ffyH:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fin ETTA (YJJK) ABCF
FAMILY PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran)
PF12848
(ABC_tran_Xtn) 		3 GLU A 274
TRP A 275
ASN A 485
 None
 1.08A 5dv4A-4finA:
undetectable		 5dv4A-4finA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		3 GLU A  84
TRP A  34
ASN A 207
 None
None
GOL  A 505 (-2.9A)
 1.03A 5dv4A-4ha4A:
2.2		 5dv4A-4ha4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		3 GLU A  84
TRP A  85
ASN A 149
 None
 0.79A 5dv4A-4ha4A:
2.2		 5dv4A-4ha4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 GLU A 386
TRP A 384
ASN A 573
 None
 1.02A 5dv4A-4hozA:
undetectable		 5dv4A-4hozA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		3 GLU A 141
TRP A  97
ASN A 168
 None
 1.09A 5dv4A-4hq1A:
undetectable		 5dv4A-4hq1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		3 GLU D 131
TRP D 133
ASN D 122
 None
 1.13A 5dv4A-4j3oD:
undetectable		 5dv4A-4j3oD:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01699
(Na_Ca_ex) 		3 GLU A 255
TRP A 116
ASN A 284
 None
 1.04A 5dv4A-4kppA:
undetectable		 5dv4A-4kppA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 GLU A 236
TRP A 133
ASN A  98
 None
 0.65A 5dv4A-4kxbA:
undetectable		 5dv4A-4kxbA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbu SIMILAR TO
N-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF13420
(Acetyltransf_4) 		3 GLU A  37
TRP A  41
ASN A  18
 None
 1.15A 5dv4A-4mbuA:
undetectable		 5dv4A-4mbuA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		3 GLU A 391
TRP A 402
ASN A 360
 None
UNL  A 601 ( 4.3A)
None
 1.02A 5dv4A-4n0rA:
undetectable		 5dv4A-4n0rA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		3 GLU A  39
TRP A 207
ASN A 233
 MG  A 401 (-2.6A)
None
None
 0.81A 5dv4A-4oecA:
undetectable		 5dv4A-4oecA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		3 GLU A  47
TRP A 342
ASN A  14
 None
MAL  A1401 (-3.7A)
MAL  A1401 (-4.6A)
 0.99A 5dv4A-4xaiA:
undetectable		 5dv4A-4xaiA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0v 2',5'-PHOSPHODIESTER
ASE 12

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 GLU A 351
TRP A 459
ASN A 551
 MG  A 701 (-2.4A)
None
None
 0.37A 5dv4A-4z0vA:
39.5		 5dv4A-4z0vA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT
PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		3 GLU A  11
TRP C  99
ASN A 599
 None
 0.93A 5dv4A-4zohA:
undetectable		 5dv4A-4zohA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 GLU A 672
TRP A 482
ASN A 297
 MCN  A 801 ( 3.2A)
1PE  A 803 ( 4.0A)
1PE  A 803 (-4.5A)
 0.98A 5dv4A-4zohA:
undetectable		 5dv4A-4zohA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		3 GLU K 802
TRP K 801
ASN K 818
 None
 1.06A 5dv4A-5anbK:
undetectable		 5dv4A-5anbK:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2m PREDICTED PROTEIN

(Nematostella
vectensis) 		PF14517
(Tachylectin) 		3 GLU A  32
TRP A  38
ASN A  14
 None
 1.08A 5dv4A-5c2mA:
undetectable		 5dv4A-5c2mA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		3 GLU A 125
TRP A  99
ASN A  35
 None
 0.89A 5dv4A-5cb2A:
undetectable		 5dv4A-5cb2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		3 GLU A 143
TRP A  76
ASN A 225
 ZN  A 301 ( 4.2A)
None
None
 0.85A 5dv4A-5czwA:
undetectable		 5dv4A-5czwA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 GLU A 372
TRP A 342
ASN A 587
 None
 1.12A 5dv4A-5dkxA:
undetectable		 5dv4A-5dkxA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 GLU A 316
TRP A 268
ASN A 321
 PEG  A1384 (-4.4A)
PEG  A1387 ( 4.3A)
PEG  A1387 (-3.7A)
 0.83A 5dv4A-5fipA:
undetectable		 5dv4A-5fipA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		3 GLU A  75
TRP A 369
ASN A 138
 None
 1.15A 5dv4A-5g5zA:
undetectable		 5dv4A-5g5zA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 GLU A 380
TRP A 344
ASN A 595
 None
 1.05A 5dv4A-5hjrA:
undetectable		 5dv4A-5hjrA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		3 GLU A 271
TRP A 280
ASN A 264
 None
 1.12A 5dv4A-5hosA:
undetectable		 5dv4A-5hosA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsg PUTATIVE ABC
TRANSPORTER,
NUCLEOTIDE
BINDING/ATPASE
PROTEIN

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		3 GLU A 226
TRP A 250
ASN A 199
 None
 1.08A 5dv4A-5hsgA:
undetectable		 5dv4A-5hsgA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 GLU A 301
TRP A 297
ASN A 254
 None
 1.00A 5dv4A-5i1wA:
undetectable		 5dv4A-5i1wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leo LYSOSTAPHIN

(Staphylococcaceae) 		PF08460
(SH3_5) 		3 GLU A 451
TRP A 460
ASN A 405
 None
 1.06A 5dv4A-5leoA:
undetectable		 5dv4A-5leoA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 3 GLU A 565
TRP A 495
ASN A 362
 None
 1.13A 5dv4A-5mqpA:
undetectable		 5dv4A-5mqpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n40 PUTATIVE INVASIN

(Yersinia
pseudotuberculosis) 		PF05689
(DUF823)
PF09134
(Invasin_D3) 		3 GLU A2705
TRP A2748
ASN A2740
 None
 1.00A 5dv4A-5n40A:
undetectable		 5dv4A-5n40A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 GLU A  11
TRP A 210
ASN A  92
 None
 0.92A 5dv4A-5n4lA:
undetectable		 5dv4A-5n4lA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 GLU A 715
TRP A 904
ASN A 801
 None
 0.95A 5dv4A-5n4lA:
undetectable		 5dv4A-5n4lA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 3 GLU A 485
TRP A 456
ASN A 451
 None
 1.08A 5dv4A-5ndxA:
undetectable		 5dv4A-5ndxA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot4 INTERAPTIN

(Legionella
pneumophila) 		no annotation 3 GLU A 443
TRP A 436
ASN A 385
 None
 1.04A 5dv4A-5ot4A:
undetectable		 5dv4A-5ot4A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgt GLUTAMATE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c) 		3 GLU A 337
TRP A 341
ASN A 322
 None
 1.14A 5dv4A-5tgtA:
undetectable		 5dv4A-5tgtA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 3 GLU A 124
TRP A 127
ASN A 153
 None
 1.07A 5dv4A-5u6fA:
undetectable		 5dv4A-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn4 ANTI-CRISPR ACRIIA4

(Listeria
monocytogenes) 		no annotation 3 GLU X  72
TRP X  63
ASN X  35
 None
 1.14A 5dv4A-5xn4X:
undetectable		 5dv4A-5xn4X:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czs -

(-) 		no annotation 3 GLU A  98
TRP A 142
ASN A 101
 NAG  A 401 (-3.8A)
None
NAG  A 401 (-1.9A)
 1.14A 5dv4A-6czsA:
undetectable		 5dv4A-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 GLU A  48
TRP A 261
ASN A 181
 None
GLA  A 801 (-4.1A)
GLA  A 801 (-2.9A)
 1.03A 5dv4A-6eonA:
undetectable		 5dv4A-6eonA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 3 GLU A 535
TRP A 390
ASN A 635
 None
 0.96A 5dv4A-6f8zA:
undetectable		 5dv4A-6f8zA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 3 GLU B 497
TRP B 495
ASN B 504
 None
 1.14A 5dv4A-6fosB:
undetectable		 5dv4A-6fosB:
11.43