SIMILAR PATTERNS OF AMINO ACIDS FOR 5DSG_B_0HKB1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		3 ASP A 233
ASN A 245
PHE A  72
 None
 0.70A 5dsgB-1bsgA:
undetectable		 5dsgB-1bsgA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ASP A 332
ASN A 329
PHE A 387
 None
 0.76A 5dsgB-1ethA:
undetectable		 5dsgB-1ethA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		3 ASP A 358
ASN A 171
PHE A 146
 None
 0.66A 5dsgB-1f6dA:
0.0		 5dsgB-1f6dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ASP A 331
ASN A 328
PHE A 386
 None
 0.64A 5dsgB-1hplA:
0.0		 5dsgB-1hplA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		3 ASP A  90
ASN A  95
PHE A  77
 None
None
GOL  A1007 (-4.8A)
 0.73A 5dsgB-1itxA:
0.0		 5dsgB-1itxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 ASP A 332
ASN A 312
PHE A 216
 ZN  A 488 ( 2.9A)
None
None
 0.74A 5dsgB-1lamA:
0.0		 5dsgB-1lamA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia) 		PF13354
(Beta-lactamase2) 		3 ASP A 233
ASN A 245
PHE A  72
 None
 0.72A 5dsgB-1n4oA:
undetectable		 5dsgB-1n4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o70 FASCICLIN I

(Drosophila
melanogaster) 		PF02469
(Fasciclin) 		3 ASP A 460
ASN A 364
PHE A 336
 None
SO4  A1627 (-4.3A)
None
 0.80A 5dsgB-1o70A:
undetectable		 5dsgB-1o70A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk0 CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA) 		3 ASP A 590
ASN A 607
PHE A 614
 None
 0.72A 5dsgB-1pk0A:
0.2		 5dsgB-1pk0A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans) 		PF00232
(Glyco_hydro_1) 		3 ASP A  31
ASN A  29
PHE A  87
 None
 0.79A 5dsgB-1qvbA:
undetectable		 5dsgB-1qvbA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASP A 203
ASN A 534
PHE A 529
 None
 0.54A 5dsgB-1rrhA:
undetectable		 5dsgB-1rrhA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upn ECHOVIRUS 11 COAT
PROTEIN VP3

(Enterovirus B) 		PF00073
(Rhv) 		3 ASP C  66
ASN C  57
PHE C  83
 None
 0.75A 5dsgB-1upnC:
undetectable		 5dsgB-1upnC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		3 ASP A 245
ASN A 278
PHE A 274
 None
 0.68A 5dsgB-1wleA:
2.7		 5dsgB-1wleA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z56 DNA LIGASE IV

(Saccharomyces
cerevisiae) 		PF00533
(BRCT) 		3 ASP C 765
ASN C 804
PHE C 802
 None
 0.80A 5dsgB-1z56C:
undetectable		 5dsgB-1z56C:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		3 ASP A 715
ASN A 709
PHE A 721
 None
 0.78A 5dsgB-2a3lA:
undetectable		 5dsgB-2a3lA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc1 BETA-LACTAMASE

(Mycolicibacterium
fortuitum) 		PF13354
(Beta-lactamase2) 		3 ASP A 233
ASN A 245
PHE A  72
 None
 0.67A 5dsgB-2cc1A:
undetectable		 5dsgB-2cc1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czr TBP-INTERACTING
PROTEIN

(Thermococcus
kodakarensis) 		PF15517
(TBPIP_N) 		3 ASP A  60
ASN A  79
PHE A  82
 None
None
GOL  A1001 ( 4.8A)
 0.79A 5dsgB-2czrA:
undetectable		 5dsgB-2czrA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK

(Mus musculus) 		PF00017
(SH2) 		3 ASP A  38
ASN A  13
PHE A  34
 None
 0.77A 5dsgB-2eu0A:
undetectable		 5dsgB-2eu0A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmc HYDROPHOBIN

(Neurospora
crassa) 		no annotation 3 ASP A  64
ASN A  67
PHE A  72
 None
 0.80A 5dsgB-2fmcA:
undetectable		 5dsgB-2fmcA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hkr AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT

(Alcaligenes
faecalis) 		PF02975
(Me-amine-dh_L) 		3 ASP D  76
ASN D  73
PHE D  86
 None
 0.79A 5dsgB-2hkrD:
undetectable		 5dsgB-2hkrD:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifw SCYTALIDOPEPSIN B

(Scytalidium
lignicola) 		PF01828
(Peptidase_A4) 		3 ASP A 190
ASN A 187
PHE A 150
 None
 0.75A 5dsgB-2ifwA:
undetectable		 5dsgB-2ifwA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		3 ASP A  48
ASN A 123
PHE A 129
 None
 0.76A 5dsgB-2incA:
0.7		 5dsgB-2incA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASP A 199
ASN A 529
PHE A 524
 None
 0.55A 5dsgB-2iujA:
undetectable		 5dsgB-2iujA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASP A 211
ASN A 541
PHE A 536
 None
 0.69A 5dsgB-2iukA:
undetectable		 5dsgB-2iukA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		3 ASP X 407
ASN X 410
PHE X 304
 None
 0.72A 5dsgB-2jfeX:
undetectable		 5dsgB-2jfeX:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5s COAT PROTEIN

(Salmonella
virus P22) 		PF11651
(P22_CoatProtein) 		3 ASP A 317
ASN A 331
PHE A 275
 None
 0.78A 5dsgB-2m5sA:
undetectable		 5dsgB-2m5sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mgy TRANSLOCATOR PROTEIN

(Mus musculus) 		PF03073
(TspO_MBR) 		3 ASP A 157
ASN A 151
PHE A 146
 None
PKA  A 201 ( 4.1A)
PKA  A 201 ( 4.6A)
 0.78A 5dsgB-2mgyA:
undetectable		 5dsgB-2mgyA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		3 ASP A 202
ASN A 207
PHE A 213
 None
 0.77A 5dsgB-2vk9A:
2.8		 5dsgB-2vk9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y23 MYOMESIN

(Homo sapiens) 		PF07679
(I-set) 		3 ASP A1322
ASN A1327
PHE A1318
 None
 0.74A 5dsgB-2y23A:
undetectable		 5dsgB-2y23A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		3 ASP A 131
ASN A 136
PHE A 140
 None
 0.57A 5dsgB-2yp1A:
undetectable		 5dsgB-2yp1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		3 ASP A 189
ASN A 178
PHE A 172
 None
 0.71A 5dsgB-3abbA:
1.2		 5dsgB-3abbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 ASP A 201
ASN A 160
PHE A 158
 SPM  A 501 ( 3.8A)
None
None
 0.73A 5dsgB-3c6mA:
undetectable		 5dsgB-3c6mA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwz BETA-LACTAMASE

(Mycobacterium
tuberculosis) 		PF13354
(Beta-lactamase2) 		3 ASP A 249
ASN A 260
PHE A  86
 None
 0.71A 5dsgB-3dwzA:
undetectable		 5dsgB-3dwzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
hyorhinis) 		PF06646
(Mycoplasma_p37) 		3 ASP A 373
ASN A 366
PHE A  80
 None
 0.77A 5dsgB-3e79A:
undetectable		 5dsgB-3e79A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb8 CYSTEINE
PROTEASE-LIKE VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		3 ASP A 214
ASN A 244
PHE A 254
 None
 0.77A 5dsgB-3eb8A:
undetectable		 5dsgB-3eb8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee1 EFFECTOR PROTEIN
VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		3 ASP A 214
ASN A 244
PHE A 254
 None
 0.65A 5dsgB-3ee1A:
undetectable		 5dsgB-3ee1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase) 		3 ASP A  23
ASN A  56
PHE A  58
 None
 0.76A 5dsgB-3ek5A:
undetectable		 5dsgB-3ek5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1v GLUCOKINASE

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 ASP X 409
ASN X 231
PHE X 152
 None
GLC  X 500 (-3.8A)
None
 0.78A 5dsgB-3h1vX:
undetectable		 5dsgB-3h1vX:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD

(Bacillus cereus) 		PF08713
(DNA_alkylation) 		3 ASP A 122
ASN A  92
PHE A  98
 None
 0.51A 5dsgB-3jxzA:
undetectable		 5dsgB-3jxzA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kew DHHA1 DOMAIN PROTEIN

(Clostridium
perfringens) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 ASP A 127
ASN A 113
PHE A 110
 None
 0.71A 5dsgB-3kewA:
undetectable		 5dsgB-3kewA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		3 ASP A 246
ASN A 257
PHE A  87
 None
 0.69A 5dsgB-3lezA:
undetectable		 5dsgB-3lezA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3off LDLR CHAPERONE BOCA

(Drosophila
melanogaster) 		PF10185
(Mesd) 		3 ASP A 110
ASN A 135
PHE A  97
 None
 0.77A 5dsgB-3offA:
undetectable		 5dsgB-3offA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opx PROTEIN SSM1

(Saccharomyces
cerevisiae) 		PF13419
(HAD_2) 		3 ASP A  70
ASN A  75
PHE A  59
 None
 0.71A 5dsgB-3opxA:
undetectable		 5dsgB-3opxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p09 BETA-LACTAMASE

(Francisella
tularensis) 		PF13354
(Beta-lactamase2) 		3 ASP A 225
ASN A 237
PHE A  63
 None
 0.66A 5dsgB-3p09A:
undetectable		 5dsgB-3p09A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pow CALRETICULIN

(Homo sapiens) 		PF00262
(Calreticulin) 		3 ASP A 309
ASN A 115
PHE A 113
 None
 0.80A 5dsgB-3powA:
undetectable		 5dsgB-3powA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		3 ASP A 582
ASN A 579
PHE A 257
 None
 0.73A 5dsgB-3ps9A:
undetectable		 5dsgB-3ps9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbs MYOMESIN-1

(Homo sapiens) 		PF07679
(I-set) 		3 ASP A1322
ASN A1327
PHE A1318
 None
 0.72A 5dsgB-3rbsA:
undetectable		 5dsgB-3rbsA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		3 ASP L  37
ASN L  44
PHE L   9
 None
 0.53A 5dsgB-3rgwL:
0.4		 5dsgB-3rgwL:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsj BONT/F

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 ASP A 896
ASN A 894
PHE A1049
 None
 0.77A 5dsgB-3rsjA:
undetectable		 5dsgB-3rsjA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		3 ASP A 610
ASN A 615
PHE A 546
 None
 0.54A 5dsgB-3s51A:
undetectable		 5dsgB-3s51A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		3 ASP A 110
ASN A 105
PHE A  87
 None
 0.63A 5dsgB-3t33A:
undetectable		 5dsgB-3t33A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN NUP82

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 184
ASN A 198
PHE A 285
 None
 0.53A 5dsgB-3tknA:
1.3		 5dsgB-3tknA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0i VOLTAGE-SENSOR
CONTAINING
PHOSPHATASE

(Ciona
intestinalis) 		PF00782
(DSPc)
PF10409
(PTEN_C2) 		3 ASP A 487
ASN A 456
PHE A 476
 None
 0.77A 5dsgB-3v0iA:
undetectable		 5dsgB-3v0iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		3 ASP A 108
ASN A  87
PHE A  82
 None
 0.73A 5dsgB-3va6A:
undetectable		 5dsgB-3va6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 ASP A 121
ASN A 196
PHE A 172
 None
 0.58A 5dsgB-3vlaA:
undetectable		 5dsgB-3vlaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 ASP A 121
ASN A 196
PHE A 194
 None
 0.58A 5dsgB-3vlaA:
undetectable		 5dsgB-3vlaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		3 ASP A 486
ASN A 431
PHE A 478
 None
 0.75A 5dsgB-3vm5A:
undetectable		 5dsgB-3vm5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4q BETA-LACTAMASE

(Burkholderia
multivorans) 		PF13354
(Beta-lactamase2) 		3 ASP A 233
ASN A 245
PHE A  72
 None
 0.74A 5dsgB-3w4qA:
undetectable		 5dsgB-3w4qA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		3 ASP A 380
ASN A 385
PHE A 232
 None
NAG  A 603 (-3.7A)
None
 0.69A 5dsgB-3wmtA:
undetectable		 5dsgB-3wmtA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		3 ASP A 339
ASN A 335
PHE A 333
 None
 0.79A 5dsgB-3wstA:
undetectable		 5dsgB-3wstA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a14 KINESIN-LIKE PROTEIN
KIF7

(Homo sapiens) 		PF00225
(Kinesin) 		3 ASP A 135
ASN A 131
PHE A  79
 None
 0.79A 5dsgB-4a14A:
undetectable		 5dsgB-4a14A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		3 ASP A 262
ASN A 267
PHE A 272
 None
 0.71A 5dsgB-4a1fA:
undetectable		 5dsgB-4a1fA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		3 ASP A  38
ASN A  45
PHE A  10
 None
 0.54A 5dsgB-4c3oA:
undetectable		 5dsgB-4c3oA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6y BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		3 ASP A 233
ASN A 245
PHE A  72
 None
 0.72A 5dsgB-4c6yA:
undetectable		 5dsgB-4c6yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c75 BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		3 ASP A 233
ASN A 245
PHE A  72
 None
 0.73A 5dsgB-4c75A:
undetectable		 5dsgB-4c75A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 ASP A 459
ASN A 750
PHE A 755
 None
 0.76A 5dsgB-4g9iA:
undetectable		 5dsgB-4g9iA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF13646
(HEAT_2) 		3 ASP A 147
ASN A 176
PHE A 171
 None
 0.73A 5dsgB-4l7mA:
undetectable		 5dsgB-4l7mA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsz DARPIN D7.18

(synthetic
construct) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		3 ASP E 123
ASN E 118
PHE E 145
 None
 0.66A 5dsgB-4lszE:
undetectable		 5dsgB-4lszE:
17.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		3 ASP A 103
ASN A 108
PHE A 195
 IXO  A 501 (-3.4A)
IXO  A 501 (-4.3A)
None
 0.78A 5dsgB-4mqtA:
33.7		 5dsgB-4mqtA:
60.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		3 ASP A  48
ASN A 123
PHE A 129
 None
 0.77A 5dsgB-4p1cA:
undetectable		 5dsgB-4p1cA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 ASP A3684
ASN A3654
PHE A3661
 None
 0.74A 5dsgB-4rh7A:
undetectable		 5dsgB-4rh7A:
7.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ASP A 147
ASN A 152
PHE A 239
 0HK  A2000 (-3.2A)
0HK  A2000 ( 4.7A)
None
 0.59A 5dsgB-4u14A:
37.8		 5dsgB-4u14A:
67.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ASP A 147
ASN A 152
PHE A 239
 3C0  A1202 (-3.4A)
None
None
 0.66A 5dsgB-4u16A:
42.6		 5dsgB-4u16A:
75.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uei STEROL CARRIER
PROTEIN
2/3-OXOACYL-COA
THIOLASE

(Helicoverpa
armigera) 		PF02036
(SCP2) 		3 ASP A  95
ASN A 105
PHE A 111
 None
 0.73A 5dsgB-4ueiA:
undetectable		 5dsgB-4ueiA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3i VCA0115

(Vibrio cholerae) 		PF09850
(DotU) 		3 ASP A  34
ASN A  37
PHE A 155
 None
 0.75A 5dsgB-4v3iA:
undetectable		 5dsgB-4v3iA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 ASP A 877
ASN A 875
PHE A1031
 None
 0.73A 5dsgB-4zktA:
undetectable		 5dsgB-4zktA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S RIBOSOMAL
PROTEIN L23

(Dictyostelium
discoideum) 		PF00238
(Ribosomal_L14) 		3 ASP E  27
ASN E  24
PHE E  95
 None
 0.79A 5dsgB-5an9E:
undetectable		 5dsgB-5an9E:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		3 ASP A 210
ASN A 221
PHE A  49
 None
 0.65A 5dsgB-5e2eA:
undetectable		 5dsgB-5e2eA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e43 BETA-LACTAMASE

(Streptosporangium
roseum) 		PF13354
(Beta-lactamase2) 		3 ASP A 234
ASN A 246
PHE A  72
 None
 0.73A 5dsgB-5e43A:
undetectable		 5dsgB-5e43A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		3 ASP A 203
ASN A 200
PHE A 196
 None
 0.76A 5dsgB-5eo6A:
undetectable		 5dsgB-5eo6A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		3 ASP A 226
ASN A 237
PHE A  64
 None
 0.74A 5dsgB-5eoeA:
undetectable		 5dsgB-5eoeA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis) 		PF13354
(Beta-lactamase2) 		3 ASP A 233
ASN A 245
PHE A  72
 None
 0.71A 5dsgB-5gl9A:
undetectable		 5dsgB-5gl9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		3 ASP A 232
ASN A 243
PHE A  72
 None
 0.69A 5dsgB-5hw3A:
undetectable		 5dsgB-5hw3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 3 ASP A 274
ASN A 269
PHE A 308
 None
 0.78A 5dsgB-5iwzA:
undetectable		 5dsgB-5iwzA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		3 ASP A 363
ASN A 368
PHE A 354
 COA  B 202 (-3.0A)
None
None
 0.78A 5dsgB-5k04A:
1.0		 5dsgB-5k04A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 ASP A 368
ASN A 363
PHE A 357
 ASP  A 368 ( 0.5A)
ASN  A 363 ( 0.6A)
PHE  A 357 ( 1.3A)
 0.66A 5dsgB-5l5nA:
undetectable		 5dsgB-5l5nA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 3 ASP A 599
ASN A 593
PHE A 426
 None
SO4  A1005 ( 4.0A)
None
 0.76A 5dsgB-5lewA:
undetectable		 5dsgB-5lewA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loe GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Bacillus
subtilis) 		PF06018
(CodY)
PF08222
(HTH_CodY) 		3 ASP A 195
ASN A 197
PHE A 249
 None
 0.79A 5dsgB-5loeA:
undetectable		 5dsgB-5loeA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		3 ASP S 240
ASN S 235
PHE S 274
 None
 0.65A 5dsgB-5mpdS:
undetectable		 5dsgB-5mpdS:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 3 ASP A 166
ASN A 214
PHE A 221
 None
 0.75A 5dsgB-5o7gA:
undetectable		 5dsgB-5o7gA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ASP A  87
ASN A 351
PHE A 381
 None
None
EDO  A 907 (-3.6A)
 0.76A 5dsgB-5t98A:
undetectable		 5dsgB-5t98A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 3 ASP A 193
ASN A 200
PHE A 207
 None
 0.76A 5dsgB-5tu4A:
undetectable		 5dsgB-5tu4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		3 ASP A 416
ASN A 421
PHE A 428
 None
 0.75A 5dsgB-5u47A:
undetectable		 5dsgB-5u47A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6i TMV RESISTANCE
PROTEIN Y3

(Coprinus
comatus) 		no annotation 3 ASP A  32
ASN A  30
PHE A  28
 None
 0.79A 5dsgB-5v6iA:
undetectable		 5dsgB-5v6iA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpq BETA-LACTAMASE

(Paraburkholderia
phymatum) 		PF13354
(Beta-lactamase2) 		3 ASP A 224
ASN A 235
PHE A  60
 None
 0.72A 5dsgB-5vpqA:
undetectable		 5dsgB-5vpqA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL

(Legionella
pneumophila) 		no annotation 3 ASP A  70
ASN A  65
PHE A 164
 None
 0.79A 5dsgB-5ytiA:
3.8		 5dsgB-5ytiA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 3 ASP A 482
ASN A 568
PHE A 564
 None
 0.80A 5dsgB-6cipA:
undetectable		 5dsgB-6cipA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		no annotation 3 ASP A  99
ASN A 348
PHE A 109
 None
 0.68A 5dsgB-6fthA:
undetectable		 5dsgB-6fthA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		3 ASP B 200
ASN B 281
PHE B 277
 None
 0.53A 5dsgB-6reqB:
undetectable		 5dsgB-6reqB:
20.87