SIMILAR PATTERNS OF AMINO ACIDS FOR 5DPD_B_SAMB601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 TYR A 234
ASP A 194
GLN A 222
VAL A 180
VAL A 141
 None
 1.17A 5dpdB-1airA:
undetectable		 5dpdB-1airA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis) 		PF02900
(LigB) 		5 GLY B 162
LEU B 168
VAL B 244
TRP B 246
VAL B 152
 None
 1.08A 5dpdB-1bouB:
undetectable		 5dpdB-1bouB:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3r CELL DIVISION
INHIBITOR

(Pyrococcus
furiosus) 		PF13614
(AAA_31) 		5 LEU A  23
SER A  24
ILE A 197
VAL A 140
VAL A 169
 None
None
ACP  A 238 (-4.8A)
None
None
 1.08A 5dpdB-1g3rA:
undetectable		 5dpdB-1g3rA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz6 ESTRADIOL 17
BETA-DEHYDROGENASE 4

(Rattus
norvegicus) 		PF00106
(adh_short) 		5 GLY A  16
ASP A  40
LEU A  41
SER A  75
VAL A 122
 NAI  A1306 (-3.6A)
NAI  A1306 (-2.8A)
NAI  A1306 (-4.2A)
NAI  A1306 (-3.2A)
NAI  A1306 ( 4.1A)
 0.73A 5dpdB-1gz6A:
7.0		 5dpdB-1gz6A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLY A  85
LEU A 285
VAL A 135
VAL A  77
VAL A  93
 None
 1.09A 5dpdB-1ir6A:
undetectable		 5dpdB-1ir6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3a PROTO-ONCOGENE C-CRK

(Mus musculus) 		PF00018
(SH3_1) 		5 LEU A 151
ILE A 161
VAL A 184
VAL A 187
VAL A 137
 None
 1.17A 5dpdB-1m3aA:
undetectable		 5dpdB-1m3aA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkv HYPOTHETICAL PROTEIN
YJHP

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 TYR A  25
GLY A  44
ASP A  66
SER A  68
ILE A 115
 None
 1.02A 5dpdB-1nkvA:
11.8		 5dpdB-1nkvA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Aquifex
aeolicus) 		PF01746
(tRNA_m1G_MT) 		5 GLY A 115
LEU A  11
ILE A  88
VAL A 120
VAL A 124
 None
 1.02A 5dpdB-1oy5A:
undetectable		 5dpdB-1oy5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwr FILAMENTOUS
HEMAGGLUTININ

(Bordetella
pertussis) 		PF05860
(Haemagg_act) 		5 GLY A 151
LEU A 169
VAL A 111
VAL A 145
VAL A 162
 None
 1.09A 5dpdB-1rwrA:
undetectable		 5dpdB-1rwrA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		5 GLY A   9
ASP A  33
LEU A  34
VAL A  76
VAL A 100
 ADN  A1001 (-3.5A)
ADN  A1001 (-2.9A)
ADN  A1001 (-4.3A)
None
ADN  A1001 ( 4.4A)
 0.92A 5dpdB-1uayA:
4.4		 5dpdB-1uayA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 GLY A  47
ASP A  50
ILE A  19
VAL A  96
VAL A 137
 None
 1.13A 5dpdB-1vljA:
undetectable		 5dpdB-1vljA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 GLY A 208
LEU A 181
ILE A 129
VAL A 211
VAL A 191
 None
 1.04A 5dpdB-1x3lA:
3.3		 5dpdB-1x3lA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqb HYPOTHETICAL UPF0066
PROTEIN HI0510

(Haemophilus
influenzae) 		PF01980
(UPF0066) 		5 GLY A 122
LEU A 107
SER A  55
VAL A 124
VAL A  36
 None
 1.04A 5dpdB-1xqbA:
undetectable		 5dpdB-1xqbA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 146
SER A 123
ILE A 245
VAL A  77
VAL A 246
 None
 0.94A 5dpdB-1y6jA:
4.6		 5dpdB-1y6jA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF13649
(Methyltransf_25) 		5 TYR A  21
ASP A  67
LEU A  68
SER A  69
ILE A  94
 None
 0.86A 5dpdB-1y8cA:
18.1		 5dpdB-1y8cA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL)
PF16195
(UBA2_C) 		5 GLY B  24
ASP B  48
LEU B  49
SER B  95
ILE B  96
 ATP  B 802 ( 3.9A)
ATP  B 802 (-2.9A)
ATP  B 802 (-4.3A)
ATP  B 802 (-3.2A)
ATP  B 802 (-4.2A)
 0.96A 5dpdB-1y8qB:
6.9		 5dpdB-1y8qB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN

(Homo sapiens) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 ASP A 292
LEU A 291
SER A 336
VAL A 373
VAL A 328
 None
 1.17A 5dpdB-1z5vA:
undetectable		 5dpdB-1z5vA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		5 GLY A  50
ASP A  71
SER A  73
VAL A 112
VAL A 116
 SAI  A1300 (-3.5A)
SAI  A1300 (-2.9A)
SAI  A1300 (-4.7A)
SAI  A1300 (-3.9A)
SAI  A1300 ( 4.0A)
 0.74A 5dpdB-2avnA:
13.1		 5dpdB-2avnA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bod ENDOGLUCANASE E-2

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		5 GLY X 141
SER X 148
ILE X  98
VAL X 114
VAL X  72
 None
 1.01A 5dpdB-2bodX:
undetectable		 5dpdB-2bodX:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 GLY A 171
LEU A 177
ILE A 145
VAL A 163
VAL A 161
 None
 1.11A 5dpdB-2c2yA:
4.1		 5dpdB-2c2yA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvj V-CRK SARCOMA VIRUS
CT10 ONCOGENE
HOMOLOG, ISOFORM A

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		5 LEU A 151
ILE A 161
VAL A 184
VAL A 187
VAL A 137
 None
 1.02A 5dpdB-2dvjA:
undetectable		 5dpdB-2dvjA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhd DNA REPAIR PROTEIN
RHP9/CRB2

(Schizosaccharomyces
pombe) 		no annotation 5 ASP A 453
ILE A 476
VAL A 460
VAL A 436
VAL A 424
 None
 1.13A 5dpdB-2fhdA:
undetectable		 5dpdB-2fhdA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1

(Porphyromonas
gingivalis) 		PF00274
(Glycolytic) 		5 ASP A  20
GLN A  21
ILE A 174
VAL A  16
VAL A 234
 None
 1.11A 5dpdB-2iqtA:
undetectable		 5dpdB-2iqtA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		5 TYR A  61
GLY A 162
LEU A 267
SER A 266
VAL A 173
 None
 1.12A 5dpdB-2j6lA:
3.5		 5dpdB-2j6lA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lg7 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF14466
(PLCC) 		5 LEU A  66
SER A  67
ILE A  17
VAL A  77
VAL A  30
 None
 1.17A 5dpdB-2lg7A:
undetectable		 5dpdB-2lg7A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7a SIALIC ACID-BINDING
IG-LIKE LECTIN 8

(Homo sapiens) 		PF07686
(V-set) 		5 SER A 105
ILE A  95
VAL A 134
VAL A  21
VAL A  27
 None
 1.15A 5dpdB-2n7aA:
undetectable		 5dpdB-2n7aA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5a BH1328 PROTEIN

(Bacillus
halodurans) 		PF02410
(RsfS) 		5 LEU A  55
GLN A  60
ILE A  51
VAL A  78
VAL A  89
 None
 1.13A 5dpdB-2o5aA:
undetectable		 5dpdB-2o5aA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE

(Acetobacter
pasteurianus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 GLY A 412
GLN A 444
SER A 417
VAL A 434
VAL A 432
VAL A 381
 None
 1.34A 5dpdB-2vbiA:
2.0		 5dpdB-2vbiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC

(Lactobacillus
hilgardii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A 181
LEU A 177
SER A 176
VAL A 151
VAL A 232
 None
 1.14A 5dpdB-2w37A:
4.3		 5dpdB-2w37A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		5 GLY A  82
ASP A  81
SER A  77
SER A 166
VAL A  73
 None
 1.13A 5dpdB-2w5fA:
undetectable		 5dpdB-2w5fA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1

(Saccharomyces
cerevisiae) 		PF12697
(Abhydrolase_6) 		5 LEU A 232
SER A 229
GLN A 230
VAL A  66
TRP A  68
 None
 1.12A 5dpdB-2y6vA:
undetectable		 5dpdB-2y6vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLY A  85
LEU A 285
VAL A 135
VAL A  77
VAL A  93
 None
 1.14A 5dpdB-2zxoA:
3.2		 5dpdB-2zxoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		6 GLY A 256
ASP A 258
LEU A 260
SER A 259
VAL A 297
VAL A 276
 None
 1.31A 5dpdB-3afgA:
undetectable		 5dpdB-3afgA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak4 NADH-DEPENDENT
QUINUCLIDINONE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		5 GLY A  16
ASP A  40
LEU A  41
VAL A  93
VAL A 113
 NAD  A 901 (-3.6A)
NAD  A 901 (-2.8A)
NAD  A 901 (-3.9A)
None
NAD  A 901 ( 4.5A)
 0.92A 5dpdB-3ak4A:
5.6		 5dpdB-3ak4A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		5 TYR A 375
SER A 364
ILE A 287
VAL A 381
VAL A 293
 None
 1.00A 5dpdB-3buzA:
undetectable		 5dpdB-3buzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		5 TYR A  19
GLY A  40
ASP A  60
LEU A  61
SER A  62
 None
 0.71A 5dpdB-3d2lA:
16.9		 5dpdB-3d2lA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmm T-CELL SURFACE
GLYCOPROTEIN CD8
ALPHA CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD8
BETA CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		5 TYR C 111
GLY D  60
ASP D  64
ILE D  69
VAL D  57
 None
 0.99A 5dpdB-3dmmC:
undetectable		 5dpdB-3dmmC:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5l PUTATIVE
S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF13649
(Methyltransf_25) 		5 GLY A  50
ASP A  72
LEU A  73
SER A  74
ILE A  97
 None
 0.51A 5dpdB-3g5lA:
15.1		 5dpdB-3g5lA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF13847
(Methyltransf_31) 		6 TYR A  21
GLY A  44
ASP A  68
LEU A  69
SER A  70
SER A  97
 SAH  A 308 (-4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-2.6A)
SAH  A 308 (-4.1A)
SAH  A 308 (-4.8A)
SAH  A 308 (-3.7A)
 0.85A 5dpdB-3g5tA:
10.9		 5dpdB-3g5tA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		5 TYR A 344
GLY A 324
LEU A  14
VAL A 305
VAL A   6
 None
 1.16A 5dpdB-3h8lA:
2.7		 5dpdB-3h8lA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		5 GLY A 721
ASP A 745
SER A 778
ILE A 779
VAL A 797
 SAH  A 951 (-4.3A)
SAH  A 951 (-2.8A)
SAH  A 951 (-3.2A)
SAH  A 951 (-3.9A)
SAH  A 951 (-3.9A)
 0.92A 5dpdB-3htxA:
13.7		 5dpdB-3htxA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		5 GLY A 177
ASP A 200
LEU A 201
SER A 227
VAL A 244
 SAH  A 401 (-3.9A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.3A)
SAH  A 401 ( 4.5A)
 0.85A 5dpdB-3i58A:
14.0		 5dpdB-3i58A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilr HEPARIN LYASE I

(Bacteroides
thetaiotaomicron) 		PF14099
(Polysacc_lyase) 		5 GLY A 117
ASP A  95
SER A  25
VAL A  37
VAL A  19
 None
None
EDO  A   5 ( 4.5A)
None
None
 1.06A 5dpdB-3ilrA:
undetectable		 5dpdB-3ilrA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwi METHYLTRANSFERASE
TYPE 12

(Ruminiclostridium
thermocellum) 		PF08242
(Methyltransf_12) 		5 GLY A  37
ASP A  60
SER A  62
SER A  91
VAL A 111
 None
 1.06A 5dpdB-3jwiA:
14.5		 5dpdB-3jwiA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwi METHYLTRANSFERASE
TYPE 12

(Ruminiclostridium
thermocellum) 		PF08242
(Methyltransf_12) 		5 GLY A  37
ASP A  60
SER A  62
SER A  92
VAL A 111
 None
 0.73A 5dpdB-3jwiA:
14.5		 5dpdB-3jwiA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvd LIPOPROTEIN

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		5 GLY D 315
SER D 288
ILE D 246
VAL D 305
VAL D 256
 None
 1.15A 5dpdB-3kvdD:
undetectable		 5dpdB-3kvdD:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL) 		5 GLY B  24
ASP B  48
LEU B  49
SER B  95
ILE B  96
 None
 0.96A 5dpdB-3kydB:
6.7		 5dpdB-3kydB:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meq ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Brucella suis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  69
LEU A 342
SER A  39
VAL A  34
VAL A 128
 None
 1.01A 5dpdB-3meqA:
4.2		 5dpdB-3meqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei) 		PF13847
(Methyltransf_31) 		5 GLY A  43
ASP A  66
SER A  68
ILE A  94
VAL A 112
 None
 0.62A 5dpdB-3mggA:
4.0		 5dpdB-3mggA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt0 UNCHARACTERIZED
PROTEIN PA1789

(Pseudomonas
aeruginosa) 		PF00582
(Usp) 		5 GLY A 163
ASP A 160
GLN A   2
ILE A 134
VAL A 237
 None
 1.14A 5dpdB-3mt0A:
4.4		 5dpdB-3mt0A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L2P

(Haloarcula
marismortui) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		5 GLY A  91
ILE A  68
VAL A  74
VAL A  42
VAL A  58
 None
 1.10A 5dpdB-3ow2A:
undetectable		 5dpdB-3ow2A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE

(Aliivibrio
fischeri) 		PF02719
(Polysacc_synt_2) 		5 GLY A  39
ASP A  64
SER A  66
ILE A  95
VAL A 137
 NAD  A 501 ( 3.7A)
NAD  A 501 (-2.6A)
None
NAD  A 501 (-3.9A)
NAD  A 501 ( 4.6A)
 0.95A 5dpdB-3pvzA:
7.4		 5dpdB-3pvzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe3 SORBITOL
DEHYDROGENASE

(Ovis aries) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 178
ASP A 202
LEU A 203
SER A 204
VAL A 251
 None
 0.81A 5dpdB-3qe3A:
7.2		 5dpdB-3qe3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 EPITOPE SCAFFOLD
2BODX43

(Thermobifida
fusca;
Human
immunodeficiency
virus;
synthetic
construct) 		PF01341
(Glyco_hydro_6) 		5 GLY X 129
SER X 136
ILE X  90
VAL X 106
VAL X  71
 None
 1.13A 5dpdB-3ru8X:
undetectable		 5dpdB-3ru8X:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcr MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN

(Mycobacteroides
abscessus) 		PF00994
(MoCF_biosynth) 		5 GLY A 141
ASP A 108
LEU A 107
VAL A  78
VAL A  74
 None
 1.11A 5dpdB-3tcrA:
2.0		 5dpdB-3tcrA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		5 LEU A 590
SER A 589
GLN A 787
VAL A 780
VAL A 600
 None
 1.11A 5dpdB-4a5wA:
3.5		 5dpdB-4a5wA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4an7 TRYPSIN INHIBITOR

(Tamarindus
indica) 		PF00197
(Kunitz_legume) 		5 GLY B 148
LEU B 131
VAL B 160
VAL B 108
VAL B  46
 None
 1.17A 5dpdB-4an7B:
undetectable		 5dpdB-4an7B:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dey VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-2

(Oryctolagus
cuniculus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 LEU A 335
SER A 334
ILE A 324
VAL A 339
VAL A 231
 None
BR  A 512 (-4.6A)
None
None
None
 1.17A 5dpdB-4deyA:
undetectable		 5dpdB-4deyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyv SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF00106
(adh_short) 		5 GLY A 163
SER A 166
ILE A 205
VAL A  40
VAL A 240
 None
 1.05A 5dpdB-4dyvA:
6.5		 5dpdB-4dyvA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e21 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(DECARBOXYLATING)

(Geobacter
metallireducens) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 GLY A   7
ASP A  30
LEU A  31
VAL A  67
VAL A  71
 None
 1.06A 5dpdB-4e21A:
2.3		 5dpdB-4e21A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emi TODA

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 GLY A 210
SER A 227
GLN A 219
SER A 223
VAL A 149
 None
None
None
None
NAD  A 502 (-4.2A)
 1.16A 5dpdB-4emiA:
undetectable		 5dpdB-4emiA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN

(Clostridium
perfringens) 		PF12849
(PBP_like_2) 		5 GLY A 201
ILE A 203
VAL A 193
VAL A 212
VAL A 208
 None
 1.14A 5dpdB-4gd5A:
undetectable		 5dpdB-4gd5A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl3 PUTATIVE
GLUCOAMYLASE

(Bacteroides
uniformis) 		PF10091
(Glycoamylase) 		5 GLY A 158
SER A  82
ILE A  90
VAL A 411
VAL A  91
 None
 1.12A 5dpdB-4gl3A:
undetectable		 5dpdB-4gl3A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		6 GLY B  52
ASP B  73
LEU B  74
SER B  75
VAL B 121
VAL B 125
 SAM  B 301 (-3.5A)
SAM  B 301 (-3.1A)
SAM  B 301 (-4.2A)
SAM  B 301 (-4.7A)
SAM  B 301 ( 4.3A)
None
 0.68A 5dpdB-4htfB:
4.9		 5dpdB-4htfB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 GLY B  52
ASP B  73
LEU B  74
SER B  75
VAL B 125
 SAM  B 301 (-3.5A)
SAM  B 301 (-3.1A)
SAM  B 301 (-4.2A)
SAM  B 301 (-4.7A)
None
 1.01A 5dpdB-4htfB:
4.9		 5dpdB-4htfB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		5 GLY A   6
ASP A  30
LEU A  31
SER A  44
VAL A  81
 NAD  A 403 ( 3.8A)
NAD  A 403 (-2.8A)
NAD  A 403 (-3.9A)
NAD  A 403 (-3.1A)
NAD  A 403 (-4.0A)
 0.65A 5dpdB-4id9A:
4.8		 5dpdB-4id9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 TYR A  39
GLY A  64
ASP A  89
SER A  91
ILE A 118
 GEK  A 301 (-4.7A)
GEK  A 301 (-3.6A)
GEK  A 301 (-2.8A)
GEK  A 301 (-4.6A)
GEK  A 301 (-3.7A)
 1.13A 5dpdB-4iwnA:
14.8		 5dpdB-4iwnA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6r LIGHT CHAIN OF
ANTIBODY VRC23

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY L  17
GLN L  79
SER L  74
VAL L  13
VAL L  11
 None
 1.14A 5dpdB-4j6rL:
undetectable		 5dpdB-4j6rL:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN

(Clostridium
perfringens) 		PF12849
(PBP_like_2) 		5 GLY A 171
ILE A 173
VAL A 163
VAL A 182
VAL A 178
 None
 1.14A 5dpdB-4q8rA:
undetectable		 5dpdB-4q8rA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		5 TYR A 798
GLY A 448
ILE A 450
TRP A 519
VAL A 443
 None
 1.03A 5dpdB-4qi4A:
undetectable		 5dpdB-4qi4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13581
(HATPase_c_2) 		5 LEU A 332
SER A 333
GLN A 334
ILE A 240
VAL A 278
 None
 1.17A 5dpdB-4r39A:
undetectable		 5dpdB-4r39A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		5 LEU A 332
SER A 333
GLN A 334
ILE A 240
VAL A 278
 None
 1.10A 5dpdB-4r3aA:
undetectable		 5dpdB-4r3aA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 5 ASP D  84
LEU D  87
ILE D  59
VAL D  95
VAL D  93
 None
 1.08A 5dpdB-4s1vD:
5.5		 5dpdB-4s1vD:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 TYR A 476
GLY A 238
LEU A 110
SER A 121
VAL A 189
 FAD  A 601 (-4.6A)
FAD  A 601 (-3.4A)
FAD  A 601 (-4.4A)
FAD  A 601 (-2.4A)
None
 1.17A 5dpdB-4ud8A:
undetectable		 5dpdB-4ud8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		5 GLY A  14
ASP A  38
LEU A  39
VAL A  94
VAL A 114
 None
 1.00A 5dpdB-4weoA:
6.3		 5dpdB-4weoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bjx WLAL PROTEIN

(Campylobacter
jejuni) 		no annotation 5 GLY A 278
ASP A 303
SER A 305
SER A 329
ILE A 330
 NAD  A 702 (-3.2A)
NAD  A 702 (-2.7A)
NAD  A 702 (-4.4A)
NAD  A 702 (-3.2A)
NAD  A 702 (-4.0A)
 0.64A 5dpdB-5bjxA:
7.5		 5dpdB-5bjxA:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		10 GLY A  51
ASP A  74
LEU A  75
SER A  76
GLN A  79
SER A 101
ILE A 102
VAL A 120
VAL A 124
VAL A 128
 None
 0.84A 5dpdB-5dooA:
43.6		 5dpdB-5dooA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		5 GLY A  51
ASP A  74
LEU A  75
SER A  76
VAL A 124
 None
 0.94A 5dpdB-5dooA:
43.6		 5dpdB-5dooA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		8 GLY A  51
SER A  76
SER A 101
ILE A 102
VAL A 120
TRP A 123
VAL A 124
VAL A 128
 None
 0.93A 5dpdB-5dooA:
43.6		 5dpdB-5dooA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		5 LEU A  75
SER A  76
SER A 101
ILE A 102
VAL A 120
 None
 1.14A 5dpdB-5dooA:
43.6		 5dpdB-5dooA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		6 GLY A  79
ASP A 102
LEU A 103
SER A 104
GLN A 107
VAL A 152
 SAM  A 601 (-3.8A)
SAM  A 601 (-2.4A)
SAM  A 601 (-4.2A)
SAM  A 601 (-4.9A)
SAM  A 601 (-4.6A)
None
 1.23A 5dpdB-5dpdA:
57.9		 5dpdB-5dpdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		5 LEU A 103
SER A 104
SER A 129
ILE A 130
VAL A 148
 SAM  A 601 (-4.2A)
SAM  A 601 (-4.9A)
SAM  A 601 (-3.7A)
SAM  A 601 (-3.9A)
None
 1.04A 5dpdB-5dpdA:
57.9		 5dpdB-5dpdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		12 TYR A  48
GLY A  79
ASP A 102
LEU A 103
SER A 104
GLN A 107
SER A 129
ILE A 130
VAL A 148
TRP A 151
VAL A 152
VAL A 156
 None
SAM  A 601 (-3.8A)
SAM  A 601 (-2.4A)
SAM  A 601 (-4.2A)
SAM  A 601 (-4.9A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.7A)
SAM  A 601 (-3.9A)
None
None
None
SAM  A 601 (-4.6A)
 0.33A 5dpdB-5dpdA:
57.9		 5dpdB-5dpdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		6 TYR A  48
ILE A 160
VAL A 148
TRP A 151
VAL A 152
VAL A 156
 None
None
None
None
None
SAM  A 601 (-4.6A)
 1.46A 5dpdB-5dpdA:
57.9		 5dpdB-5dpdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE

(Thiobacillus
denitrificans) 		PF13847
(Methyltransf_31) 		5 GLY A  44
ASP A  66
LEU A  67
SER A  68
ILE A 115
 SAH  A 301 (-3.6A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.8A)
SAH  A 301 (-4.7A)
 0.83A 5dpdB-5epeA:
8.2		 5dpdB-5epeA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		5 GLY A 819
ASP A 818
VAL A 815
VAL A 671
VAL A 789
 None
 1.17A 5dpdB-5ijlA:
undetectable		 5dpdB-5ijlA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		5 GLY A 138
SER A 158
ILE A 157
VAL A 128
VAL A 125
 None
 1.11A 5dpdB-5inrA:
undetectable		 5dpdB-5inrA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		5 LEU A 220
SER A 221
ILE A 208
VAL A 197
VAL A 210
 None
PLP  A 501 (-2.5A)
None
None
None
 1.11A 5dpdB-5j8qA:
undetectable		 5dpdB-5j8qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		5 GLY A 523
LEU A 473
SER A 475
ILE A 501
VAL A 520
 None
 1.12A 5dpdB-5jwzA:
undetectable		 5dpdB-5jwzA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpt CITRININ POLYKETIDE
SYNTHASE

(Monascus
purpureus) 		PF08242
(Methyltransf_12) 		5 GLY A1992
ASP A2019
LEU A2020
SER A2021
ILE A2045
 SAH  A2201 (-3.2A)
SAH  A2201 (-2.0A)
SAH  A2201 (-3.7A)
None
SAH  A2201 (-3.8A)
 0.56A 5dpdB-5mptA:
13.6		 5dpdB-5mptA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n05 AUXILIARY ACTIVITY 9

(Lentinus
similis) 		PF03443
(Glyco_hydro_61) 		5 ILE A 170
VAL A   7
TRP A   8
VAL A   9
VAL A  54
 None
 1.04A 5dpdB-5n05A:
undetectable		 5dpdB-5n05A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3z SORBITOL-6-PHOSPHATE
DEHYDROGENASE

(Erwinia
amylovora) 		no annotation 5 TYR A 227
GLY A   9
ASP A  33
LEU A  34
VAL A 111
 None
 1.09A 5dpdB-5o3zA:
2.0		 5dpdB-5o3zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C

(Methanothermobacter
wolfeii) 		PF01493
(GXGXG) 		5 TYR C 135
GLY C 182
ILE C 209
VAL C 196
VAL C 211
 None
 1.17A 5dpdB-5t5iC:
undetectable		 5dpdB-5t5iC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1b EGL NINE HOMOLOG 2

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		5 GLY A 245
LEU A 256
VAL A 243
VAL A 284
VAL A 210
 None
 1.10A 5dpdB-5v1bA:
undetectable		 5dpdB-5v1bA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13

(Homo sapiens) 		PF01564
(Spermine_synth) 		5 ASP A 554
LEU A 553
ILE A 556
VAL A 523
VAL A 500
 None
 1.16A 5dpdB-5wcjA:
13.5		 5dpdB-5wcjA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5woy PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Caldanaerobacter
subterraneus) 		no annotation 5 SER A  81
GLN A  51
ILE A 108
VAL A  89
VAL A 107
 None
 1.12A 5dpdB-5woyA:
4.0		 5dpdB-5woyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 5 GLY A  85
ASP A 105
SER A  82
VAL A  63
VAL A  60
 None
 0.98A 5dpdB-5x4jA:
undetectable		 5dpdB-5x4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY

(uncultured
archaeon
MedDCM-OCT-S05-C57) 		no annotation 5 GLY A   6
ASP A  32
LEU A  33
ILE A  48
VAL A  87
 NAD  A 402 (-3.6A)
NAD  A 402 (-2.8A)
NAD  A 402 (-4.3A)
NAD  A 402 (-3.9A)
NAD  A 402 (-4.3A)
 0.74A 5dpdB-5y1gA:
4.7		 5dpdB-5y1gA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 5 GLY A 837
ASP A 864
SER A 866
ILE A 890
VAL A 912
 SAH  A1102 (-3.5A)
SAH  A1102 (-2.4A)
None
SAH  A1102 (-4.4A)
SAH  A1102 ( 4.5A)
 0.80A 5dpdB-6d6yA:
14.1		 5dpdB-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 TYR A2351
GLY A2332
SER A2084
ILE A2059
VAL A2046
 None
 1.15A 5dpdB-6fb3A:
undetectable		 5dpdB-6fb3A:
undetectable