SIMILAR PATTERNS OF AMINO ACIDS FOR 5DPD_A_SAMA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akw FLAVODOXIN

(Desulfovibrio
vulgaris) 		PF00258
(Flavodoxin_1) 		5 GLY A  82
LEU A  78
SER A  77
VAL A  53
VAL A  88
 None
 1.10A 5dpdA-1akwA:
undetectable		 5dpdA-1akwA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4
BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E;
Enterovirus E) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 GLU 3  62
GLY 3  63
LEU 2 164
SER 2 163
VAL 3  68
 None
 1.07A 5dpdA-1bev3:
undetectable		 5dpdA-1bev3:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLY A  85
LEU A 285
VAL A 135
VAL A  77
VAL A  93
 None
 1.11A 5dpdA-1ir6A:
undetectable		 5dpdA-1ir6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 GLU A 606
GLY A 605
LEU A 566
SER A 567
VAL A 151
 None
 1.08A 5dpdA-1j1wA:
undetectable		 5dpdA-1j1wA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsv GALACTOSE MUTAROTASE

(Lactococcus
lactis) 		PF01263
(Aldose_epim) 		5 GLU A 312
GLY A 310
GLN A 306
ILE A 314
VAL A 205
 None
 1.12A 5dpdA-1nsvA:
undetectable		 5dpdA-1nsvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE

(Pseudomonas sp.
P51) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 175
GLN A 173
VAL A 164
VAL A 193
VAL A 216
 None
 1.12A 5dpdA-1nu5A:
undetectable		 5dpdA-1nu5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Aquifex
aeolicus) 		PF01746
(tRNA_m1G_MT) 		5 GLY A 115
LEU A  11
ILE A  88
VAL A 120
VAL A 124
 None
 1.01A 5dpdA-1oy5A:
undetectable		 5dpdA-1oy5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9w GENERAL SECRETION
PATHWAY PROTEIN E

(Vibrio cholerae) 		PF00437
(T2SSE) 		5 GLY A 258
LEU A 384
SER A 382
ILE A 260
HIS A 352
 None
 1.11A 5dpdA-1p9wA:
2.7		 5dpdA-1p9wA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmg RHAMNOGALACTURONASE
A

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		5 SER A 213
ILE A 179
HIS A 141
VAL A 163
VAL A 181
 None
 0.97A 5dpdA-1rmgA:
undetectable		 5dpdA-1rmgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwr FILAMENTOUS
HEMAGGLUTININ

(Bordetella
pertussis) 		PF05860
(Haemagg_act) 		5 GLY A 151
LEU A 169
VAL A 111
VAL A 145
VAL A 162
 None
 1.14A 5dpdA-1rwrA:
undetectable		 5dpdA-1rwrA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 127
ILE A 133
HIS A 124
VAL A  90
VAL A 135
 None
 1.15A 5dpdA-1uufA:
4.2		 5dpdA-1uufA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjk MOLYBDOPTERIN
CONVERTING FACTOR,
SUBUNIT 1

(Pyrococcus
furiosus) 		PF02597
(ThiS) 		5 GLU A  48
GLN A  14
ILE A  38
VAL A  83
VAL A   6
 None
 1.13A 5dpdA-1vjkA:
undetectable		 5dpdA-1vjkA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 GLY A 208
LEU A 181
ILE A 129
VAL A 211
VAL A 191
 None
 1.11A 5dpdA-1x3lA:
3.3		 5dpdA-1x3lA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqb HYPOTHETICAL UPF0066
PROTEIN HI0510

(Haemophilus
influenzae) 		PF01980
(UPF0066) 		5 GLY A 122
LEU A 107
SER A  55
VAL A 124
VAL A  36
 None
 1.03A 5dpdA-1xqbA:
undetectable		 5dpdA-1xqbA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 146
SER A 123
ILE A 245
VAL A  77
VAL A 246
 None
 0.92A 5dpdA-1y6jA:
4.5		 5dpdA-1y6jA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF01420
(Methylase_S) 		5 GLU A 352
GLY A 309
LEU A 266
SER A 267
ILE A 302
 None
 1.14A 5dpdA-1yf2A:
undetectable		 5dpdA-1yf2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		5 GLU A 282
LEU A 277
GLN A 275
ILE A 294
VAL A 213
 None
 1.07A 5dpdA-1yvlA:
2.1		 5dpdA-1yvlA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 GLU A 602
GLY A 601
LEU A 562
SER A 563
VAL A 149
 None
 1.13A 5dpdA-2b0tA:
undetectable		 5dpdA-2b0tA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 GLY A  19
SER A  14
HIS A  27
VAL A  29
VAL A 213
 None
FAD  A1385 (-2.6A)
None
None
None
 1.11A 5dpdA-2bi7A:
2.8		 5dpdA-2bi7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bod ENDOGLUCANASE E-2

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		5 GLY X 141
SER X 148
ILE X  98
VAL X 114
VAL X  72
 None
 1.02A 5dpdA-2bodX:
undetectable		 5dpdA-2bodX:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Methanothermobacter
thermautotrophicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		5 GLU C 250
LEU C 197
GLN C 195
VAL C 239
VAL C 236
 None
 1.15A 5dpdA-2d6fC:
undetectable		 5dpdA-2d6fC:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ery RAS-RELATED PROTEIN
R-RAS2

(Homo sapiens) 		PF00071
(Ras) 		5 GLU A  87
GLY A  86
ILE A 111
VAL A  18
VAL A  20
 None
 1.14A 5dpdA-2eryA:
undetectable		 5dpdA-2eryA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsq ATU0111 PROTEIN

(Agrobacterium
fabrum) 		PF08975
(2H-phosphodiest) 		5 GLU A  34
GLY A  33
LEU A  73
SER A  71
SER A 182
 None
 1.11A 5dpdA-2fsqA:
undetectable		 5dpdA-2fsqA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 GLU A  64
LEU A  79
GLN A  11
ILE A 129
VAL A  92
 None
 1.09A 5dpdA-2gksA:
undetectable		 5dpdA-2gksA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 SER A 113
SER A 145
ILE A 147
VAL A  86
VAL A 152
 APR  A3001 ( 4.8A)
None
None
None
None
 0.98A 5dpdA-2hjrA:
5.1		 5dpdA-2hjrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7a SIALIC ACID-BINDING
IG-LIKE LECTIN 8

(Homo sapiens) 		PF07686
(V-set) 		5 GLU A  75
SER A 105
ILE A  95
VAL A  21
VAL A  27
 None
 1.07A 5dpdA-2n7aA:
undetectable		 5dpdA-2n7aA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7a SIALIC ACID-BINDING
IG-LIKE LECTIN 8

(Homo sapiens) 		PF07686
(V-set) 		5 SER A 105
ILE A  95
VAL A 134
VAL A  21
VAL A  27
 None
 1.10A 5dpdA-2n7aA:
undetectable		 5dpdA-2n7aA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psb YERB PROTEIN

(Bacillus
subtilis) 		PF11258
(DUF3048)
PF17479
(DUF3048_C) 		5 GLN A  74
ILE A 150
VAL A  79
VAL A  35
VAL A 101
 None
 1.16A 5dpdA-2psbA:
undetectable		 5dpdA-2psbA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptg ENOYL-ACYL CARRIER
REDUCTASE

(Eimeria tenella) 		PF13561
(adh_short_C2) 		5 GLY A 115
SER A 111
HIS A 230
VAL A 105
VAL A 129
 None
 1.10A 5dpdA-2ptgA:
5.5		 5dpdA-2ptgA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pts ADENYLOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 GLU A  76
LEU A  32
ILE A  82
VAL A  37
VAL A  96
 None
 1.05A 5dpdA-2ptsA:
2.1		 5dpdA-2ptsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pts ADENYLOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 GLU A 249
GLY A 205
GLN A 240
ILE A 207
VAL A  39
 None
 0.97A 5dpdA-2ptsA:
2.1		 5dpdA-2ptsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs7 UNCHARACTERIZED
PROTEIN

(Sulfolobus
solfataricus) 		PF13686
(DrsE_2) 		5 GLY A  25
HIS A  87
VAL A  90
VAL A  99
VAL A  38
 None
 1.08A 5dpdA-2qs7A:
2.9		 5dpdA-2qs7A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg2 CHOLOYLGLYCINE
HYDROLASE

(Clostridium
perfringens) 		PF02275
(CBAH) 		5 SER A 280
ILE A 255
HIS A  14
VAL A 172
VAL A 232
 None
 1.15A 5dpdA-2rg2A:
undetectable		 5dpdA-2rg2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE

(Acetobacter
pasteurianus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 GLY A 412
GLN A 444
SER A 417
VAL A 434
VAL A 432
VAL A 381
 None
 1.29A 5dpdA-2vbiA:
2.1		 5dpdA-2vbiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		6 GLU A  60
SER A  51
GLN A  23
VAL A  18
VAL A  31
VAL A  33
 None
ADP  A1843 (-3.3A)
None
None
None
None
 1.32A 5dpdA-2vf8A:
2.1		 5dpdA-2vf8A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		5 GLU A  36
GLY A  37
LEU A 348
SER A  27
ILE A  34
 None
 1.13A 5dpdA-2vrkA:
undetectable		 5dpdA-2vrkA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC

(Lactobacillus
hilgardii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A 181
LEU A 177
SER A 176
VAL A 151
VAL A 232
 None
 1.05A 5dpdA-2w37A:
4.6		 5dpdA-2w37A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmp PAPG PROTEIN

(Escherichia
coli) 		PF03628
(PapG_C) 		5 GLU B 296
GLY B 295
LEU B 293
SER B 263
ILE B 264
 None
 1.03A 5dpdA-2wmpB:
undetectable		 5dpdA-2wmpB:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 LEU A 601
SER A 599
SER A 603
VAL A 557
VAL A 793
 None
 1.16A 5dpdA-3bg9A:
undetectable		 5dpdA-3bg9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		5 TYR A 375
SER A 364
ILE A 287
VAL A 381
VAL A 293
 None
 1.04A 5dpdA-3buzA:
undetectable		 5dpdA-3buzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce2 PUTATIVE PEPTIDASE

(Chlamydia
abortus) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		5 LEU A 350
GLN A 352
ILE A 398
VAL A 360
VAL A 384
 None
 1.08A 5dpdA-3ce2A:
undetectable		 5dpdA-3ce2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3col PUTATIVE
TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF00440
(TetR_N) 		5 GLY A  24
LEU A  21
VAL A  28
VAL A  16
VAL A  58
 None
 1.13A 5dpdA-3colA:
undetectable		 5dpdA-3colA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		5 GLU A  49
GLY A  51
SER A  74
HIS A 109
VAL A 115
 None
SAM  A 221 (-4.0A)
SAM  A 221 (-4.6A)
SAM  A 221 ( 3.7A)
None
 1.08A 5dpdA-3e23A:
14.8		 5dpdA-3e23A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		5 LEU A 485
SER A 486
GLN A 225
VAL A 388
VAL A 452
 None
 1.11A 5dpdA-3edyA:
undetectable		 5dpdA-3edyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3

(Homo sapiens) 		PF00782
(DSPc) 		5 GLY A 127
ILE A 160
HIS A 123
VAL A  39
VAL A  33
 STT  A   1 ( 4.5A)
None
None
None
None
 1.11A 5dpdA-3f81A:
undetectable		 5dpdA-3f81A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF13847
(Methyltransf_31) 		5 TYR A  21
GLY A  44
LEU A  69
SER A  70
SER A  97
 SAH  A 308 (-4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-4.1A)
SAH  A 308 (-4.8A)
SAH  A 308 (-3.7A)
 0.79A 5dpdA-3g5tA:
10.8		 5dpdA-3g5tA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9m P-AMINOBENZOATE
SYNTHETASE,
COMPONENT I

(Cytophaga
hutchinsonii) 		PF00425
(Chorismate_bind) 		5 GLU A 120
SER A   4
ILE A 128
HIS A  48
VAL A 137
 None
 1.13A 5dpdA-3h9mA:
undetectable		 5dpdA-3h9mA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		5 GLU A 306
GLY A 305
LEU A 313
VAL A 327
VAL A 272
 None
 1.11A 5dpdA-3i58A:
14.0		 5dpdA-3i58A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		5 GLY A  13
LEU A  36
SER A 214
ILE A 217
VAL A   6
 None
 1.08A 5dpdA-3k7tA:
undetectable		 5dpdA-3k7tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpa PROBABLE UBIQUITIN
FOLD MODIFIER
CONJUGATING ENZYME

(Leishmania
major) 		PF08694
(UFC1) 		5 GLY A 140
LEU A 145
SER A 146
ILE A  96
HIS A 135
 None
 1.02A 5dpdA-3kpaA:
undetectable		 5dpdA-3kpaA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksr PUTATIVE SERINE
HYDROLASE

(Xanthomonas
campestris) 		PF00326
(Peptidase_S9) 		5 GLY A 110
LEU A 128
SER A 130
VAL A  33
VAL A 104
 None
 1.06A 5dpdA-3ksrA:
undetectable		 5dpdA-3ksrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		5 LEU A  13
SER A   9
HIS A  86
VAL A  80
VAL A  67
 None
 1.10A 5dpdA-3loyA:
undetectable		 5dpdA-3loyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meq ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Brucella suis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  69
LEU A 342
SER A  39
VAL A  34
VAL A 128
 None
 0.91A 5dpdA-3meqA:
6.2		 5dpdA-3meqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meq ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Brucella suis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 138
HIS A  80
VAL A  81
VAL A  71
VAL A  34
 None
 1.08A 5dpdA-3meqA:
6.2		 5dpdA-3meqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei) 		PF13847
(Methyltransf_31) 		5 GLU A  41
GLY A  43
SER A  68
ILE A  94
VAL A 112
 None
 0.61A 5dpdA-3mggA:
14.6		 5dpdA-3mggA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L2P

(Haloarcula
marismortui) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		5 GLY A  91
ILE A  68
VAL A  74
VAL A  42
VAL A  58
 None
 1.08A 5dpdA-3ow2A:
undetectable		 5dpdA-3ow2A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd9 QSOX FROM
TRYPANOSOMA BRUCEI
(TBQSOX)

(Trypanosoma
brucei) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 LEU A 233
SER A 232
GLN A 283
ILE A 117
VAL A 120
 None
 1.13A 5dpdA-3qd9A:
undetectable		 5dpdA-3qd9A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ray PR DOMAIN-CONTAINING
PROTEIN 11

(Homo sapiens) 		PF00856
(SET) 		5 GLU A 161
LEU A 118
SER A 128
ILE A 129
HIS A 159
 None
UNX  A 238 ( 4.2A)
None
None
None
 1.04A 5dpdA-3rayA:
undetectable		 5dpdA-3rayA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		5 TYR A 140
SER A 234
ILE A 452
HIS A 217
VAL A 170
 None
 1.15A 5dpdA-3utoA:
undetectable		 5dpdA-3utoA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		5 LEU A 590
SER A 589
GLN A 787
VAL A 780
VAL A 600
 None
 1.13A 5dpdA-4a5wA:
3.8		 5dpdA-4a5wA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az1 TYROSINE SPECIFIC
PROTEIN PHOSPHATASE

(Trypanosoma
cruzi) 		PF00102
(Y_phosphatase) 		5 GLU A 275
GLN A  22
ILE A 280
VAL A 271
VAL A 260
 None
 1.04A 5dpdA-4az1A:
undetectable		 5dpdA-4az1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 GLU A 396
GLY A 232
SER A 177
VAL A 209
VAL A  45
 None
9VU  A1539 (-3.2A)
None
9VU  A1539 (-4.9A)
9VU  A1539 (-3.9A)
 1.14A 5dpdA-4bqhA:
2.2		 5dpdA-4bqhA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY

(Burkholderia
thailandensis) 		PF02636
(Methyltransf_28) 		5 GLU A 121
GLY A 123
LEU A 152
SER A 153
VAL A 194
 None
 1.04A 5dpdA-4f3nA:
11.2		 5dpdA-4f3nA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN

(Clostridium
perfringens) 		PF12849
(PBP_like_2) 		5 GLY A 201
ILE A 203
VAL A 193
VAL A 212
VAL A 208
 None
 1.12A 5dpdA-4gd5A:
undetectable		 5dpdA-4gd5A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		6 GLY B  52
LEU B  74
SER B  75
HIS B 119
VAL B 121
VAL B 125
 SAM  B 301 (-3.5A)
SAM  B 301 (-4.2A)
SAM  B 301 (-4.7A)
None
SAM  B 301 ( 4.3A)
None
 1.18A 5dpdA-4htfB:
15.8		 5dpdA-4htfB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu2 CELL-WALL ANCHORING
PROTEIN

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin) 		5 LEU A  79
ILE A 146
HIS A  72
VAL A 130
VAL A  55
 None
 1.12A 5dpdA-4iu2A:
undetectable		 5dpdA-4iu2A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		5 GLY A 340
LEU A 336
SER A 335
VAL A 409
VAL A 381
 None
 1.11A 5dpdA-4j5uA:
undetectable		 5dpdA-4j5uA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnq INTERFERON-ACTIVABLE
PROTEIN 202

(Mus musculus) 		PF02760
(HIN) 		5 GLU A 126
ILE A 115
VAL A  96
VAL A  87
VAL A  64
 None
 1.08A 5dpdA-4lnqA:
undetectable		 5dpdA-4lnqA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 GLY A 268
LEU A 264
ILE A 295
VAL A 242
VAL A 246
 None
 1.04A 5dpdA-4n78A:
3.3		 5dpdA-4n78A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf7 ENDO-1,4-BETA-GLUCAN
ASE CEL5C

(Butyrivibrio
proteoclasticus) 		PF00150
(Cellulase) 		5 TYR A 340
GLY A 320
ILE A 136
VAL A 318
VAL A 183
 None
 1.15A 5dpdA-4nf7A:
undetectable		 5dpdA-4nf7A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovb PROTEIN OSA

(Shigella
flexneri) 		no annotation 5 GLY A  71
LEU A 144
SER A 141
VAL A  69
VAL A 154
 None
 1.12A 5dpdA-4ovbA:
undetectable		 5dpdA-4ovbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN

(Clostridium
perfringens) 		PF12849
(PBP_like_2) 		5 GLY A 171
ILE A 173
VAL A 163
VAL A 182
VAL A 178
 None
 1.12A 5dpdA-4q8rA:
undetectable		 5dpdA-4q8rA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13581
(HATPase_c_2) 		5 LEU A 332
SER A 333
GLN A 334
ILE A 240
VAL A 278
 None
 1.04A 5dpdA-4r39A:
undetectable		 5dpdA-4r39A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		5 LEU A 332
SER A 333
GLN A 334
ILE A 240
VAL A 278
 None
 0.98A 5dpdA-4r3aA:
undetectable		 5dpdA-4r3aA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9r CZCP CATION EFFLUX
P1-ATPASE

(Cupriavidus
metallidurans) 		no annotation 5 GLY A 156
LEU A 161
SER A 162
VAL A 106
VAL A 145
 None
 1.12A 5dpdA-4u9rA:
undetectable		 5dpdA-4u9rA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 TYR A 476
GLY A 238
LEU A 110
SER A 121
VAL A 189
 FAD  A 601 (-4.6A)
FAD  A 601 (-3.4A)
FAD  A 601 (-4.4A)
FAD  A 601 (-2.4A)
None
 1.11A 5dpdA-4ud8A:
undetectable		 5dpdA-4ud8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		5 GLY A 110
LEU A 108
ILE A 116
VAL A  80
VAL A 126
 None
 1.07A 5dpdA-4upiA:
undetectable		 5dpdA-4upiA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvm DNA POLYMERASE NU

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 LEU A 846
SER A 845
ILE A 814
HIS A 854
VAL A 809
 None
 1.12A 5dpdA-4xvmA:
3.8		 5dpdA-4xvmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		5 GLU A 609
GLY A 608
LEU A 569
SER A 570
VAL A 153
 None
 1.04A 5dpdA-4zdaA:
undetectable		 5dpdA-4zdaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		5 GLU A 218
GLY A 202
LEU A 204
VAL A 365
VAL A 294
 None
 1.08A 5dpdA-5ci5A:
undetectable		 5dpdA-5ci5A:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		10 GLY A  51
LEU A  75
SER A  76
GLN A  79
SER A 101
ILE A 102
HIS A 118
VAL A 120
VAL A 124
VAL A 128
 None
 0.78A 5dpdA-5dooA:
43.7		 5dpdA-5dooA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		12 TYR A  48
GLU A  77
GLY A  79
LEU A 103
SER A 104
GLN A 107
SER A 129
ILE A 130
HIS A 146
VAL A 148
VAL A 152
VAL A 156
 None
SAM  A 601 (-3.6A)
SAM  A 601 (-3.8A)
SAM  A 601 (-4.2A)
SAM  A 601 (-4.9A)
SAM  A 601 (-4.6A)
SAM  A 601 (-3.7A)
SAM  A 601 (-3.9A)
SAM  A 601 (-3.8A)
None
None
SAM  A 601 (-4.6A)
 0.00A 5dpdA-5dpdA:
61.8		 5dpdA-5dpdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		7 TYR A  48
GLU A  77
ILE A 160
HIS A 146
VAL A 148
VAL A 152
VAL A 156
 None
SAM  A 601 (-3.6A)
None
SAM  A 601 (-3.8A)
None
None
SAM  A 601 (-4.6A)
 1.49A 5dpdA-5dpdA:
61.8		 5dpdA-5dpdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 TYR A 307
GLY A 259
LEU A  81
VAL A  76
VAL A  33
 None
 0.99A 5dpdA-5ffnA:
undetectable		 5dpdA-5ffnA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0b MYELOID CELL SURFACE
ANTIGEN CD33

(Homo sapiens) 		PF00047
(ig)
PF07686
(V-set) 		6 LEU A 134
SER A 115
ILE A 105
VAL A 138
VAL A  31
VAL A  37
 None
 1.45A 5dpdA-5j0bA:
undetectable		 5dpdA-5j0bA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		5 LEU A 220
SER A 221
ILE A 208
VAL A 197
VAL A 210
 None
PLP  A 501 (-2.5A)
None
None
None
 1.03A 5dpdA-5j8qA:
undetectable		 5dpdA-5j8qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		5 GLY A 523
LEU A 473
SER A 475
ILE A 501
VAL A 520
 None
 1.03A 5dpdA-5jwzA:
undetectable		 5dpdA-5jwzA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 GLU A  76
GLY A  30
LEU A  24
VAL A  83
VAL A  36
 None
 1.10A 5dpdA-5jzxA:
undetectable		 5dpdA-5jzxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		5 GLU A 609
GLY A 608
LEU A 569
SER A 570
VAL A 153
 None
 1.07A 5dpdA-5kvuA:
2.1		 5dpdA-5kvuA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1t PENTALENOLACTONE
SYNTHASE

(Streptomyces
arenae) 		PF00067
(p450) 		5 GLU A  89
GLY A  83
LEU A  80
SER A  77
HIS A  86
 None
 1.16A 5dpdA-5l1tA:
undetectable		 5dpdA-5l1tA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljy ENVELOPMENT
POLYPROTEIN

(Hantaan
orthohantavirus) 		PF01561
(Hanta_G2) 		5 LEU A  27
ILE A  57
HIS A 180
VAL A 181
VAL A 183
 None
 1.16A 5dpdA-5ljyA:
undetectable		 5dpdA-5ljyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpt CITRININ POLYKETIDE
SYNTHASE

(Monascus
purpureus) 		PF08242
(Methyltransf_12) 		5 GLU A1990
GLY A1992
LEU A2020
SER A2021
ILE A2045
 None
SAH  A2201 (-3.2A)
SAH  A2201 (-3.7A)
None
SAH  A2201 (-3.8A)
 0.46A 5dpdA-5mptA:
13.5		 5dpdA-5mptA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3z SORBITOL-6-PHOSPHATE
DEHYDROGENASE

(Erwinia
amylovora) 		no annotation 5 GLY A 115
GLN A 110
ILE A   8
VAL A  68
VAL A  60
 None
 1.00A 5dpdA-5o3zA:
3.2		 5dpdA-5o3zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C

(Methanothermobacter
wolfeii) 		PF01493
(GXGXG) 		5 GLY C  99
GLN C 119
ILE C 107
VAL C  94
VAL C 109
 None
 1.12A 5dpdA-5t5iC:
undetectable		 5dpdA-5t5iC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t95 PREPHENATE
DEHYDROGENASE 1

(Glycine max) 		PF02153
(PDH) 		5 GLU A 164
LEU A  10
SER A   9
VAL A  70
VAL A  97
 None
 0.92A 5dpdA-5t95A:
4.5		 5dpdA-5t95A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1b EGL NINE HOMOLOG 2

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		5 GLY A 245
LEU A 256
VAL A 243
VAL A 284
VAL A 210
 None
 1.15A 5dpdA-5v1bA:
undetectable		 5dpdA-5v1bA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuo POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		no annotation 5 GLY A 727
LEU A 761
ILE A 741
HIS A 723
VAL A 756
 None
 1.13A 5dpdA-5xuoA:
undetectable		 5dpdA-5xuoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 5 GLY A 825
GLN A 823
HIS A 830
VAL A 593
VAL A 719
 None
 1.16A 5dpdA-6bfuA:
undetectable		 5dpdA-6bfuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 5 GLU A 835
GLY A 837
SER A 866
ILE A 890
VAL A 912
 None
SAH  A1102 (-3.5A)
None
SAH  A1102 (-4.4A)
SAH  A1102 ( 4.5A)
 0.68A 5dpdA-6d6yA:
14.0		 5dpdA-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-) 		no annotation 5 GLU A 606
GLY A 605
LEU A 566
SER A 567
VAL A 152
 None
 1.01A 5dpdA-6g3uA:
undetectable		 5dpdA-6g3uA:
undetectable