SIMILAR PATTERNS OF AMINO ACIDS FOR 5DLV_B_5D5B927_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)

(Agrobacterium
tumefaciens) 		PF00561
(Abhydrolase_1) 		4 SER A 153
TYR A 152
PHE A 137
HIS A 275
 None
 1.42A 5dlvB-1ehyA:
0.0		 5dlvB-1ehyA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 SER A 497
TYR A 488
LYS A 376
PHE A 377
 None
 1.21A 5dlvB-1kfiA:
1.4		 5dlvB-1kfiA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 SER A 484
TYR A 475
LYS A 359
PHE A 360
 None
 1.26A 5dlvB-1lxtA:
0.4		 5dlvB-1lxtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI

(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1)
PF14528
(LAGLIDADG_3) 		4 SER A 215
LYS A 131
PHE A 132
HIS A 134
 None
 1.14A 5dlvB-1mowA:
0.7		 5dlvB-1mowA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pf5 HYPOTHETICAL PROTEIN
YJGH

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		4 SER A  39
PHE A 118
TRP A 114
TYR A  21
 None
 1.00A 5dlvB-1pf5A:
0.0		 5dlvB-1pf5A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9i DNA ENDONUCLEASE
I-CREI

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 SER A 118
LYS A  34
PHE A  35
HIS A  37
 None
 1.28A 5dlvB-1t9iA:
0.0		 5dlvB-1t9iA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx1 HYPOTHETICAL PROTEIN
PA2260

(Pseudomonas
aeruginosa) 		PF01261
(AP_endonuc_2) 		4 SER A  11
LYS A 189
HIS A 243
TYR A 185
 None
 1.38A 5dlvB-1yx1A:
0.0		 5dlvB-1yx1A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF01522
(Polysacc_deac_1) 		4 SER A 186
TYR A 211
PHE A 100
HIS A 259
 None
 1.46A 5dlvB-1z7aA:
0.5		 5dlvB-1z7aA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		4 SER A  81
TYR A  80
PHE A  22
HIS A  39
 None
 1.34A 5dlvB-1zaoA:
3.0		 5dlvB-1zaoA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		4 SER A  40
PHE A  44
HIS A  56
TYR A  78
 None
 1.40A 5dlvB-2canA:
1.2		 5dlvB-2canA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		4 TYR A 253
HIS A 119
TRP A 120
TYR A  38
 SAM  A1001 (-4.7A)
None
None
None
 0.80A 5dlvB-2igtA:
undetectable		 5dlvB-2igtA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		4 TYR A 253
PHE A 113
HIS A 119
TRP A 120
 SAM  A1001 (-4.7A)
FMT  A1013 ( 3.5A)
None
None
 1.24A 5dlvB-2igtA:
undetectable		 5dlvB-2igtA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofs CD59 GLYCOPROTEIN

(Homo sapiens) 		PF00021
(UPAR_LY6) 		4 SER A  20
LYS A  41
PHE A  23
TRP A  40
 None
 1.42A 5dlvB-2ofsA:
undetectable		 5dlvB-2ofsA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot3 RAS-RELATED PROTEIN
RAB-21

(Homo sapiens) 		PF00071
(Ras) 		4 SER B 106
TYR B  99
LYS B 133
HIS B 160
 None
 1.09A 5dlvB-2ot3B:
undetectable		 5dlvB-2ot3B:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 SER A 269
LYS A 331
PHE A 330
TRP A 407
 None
UGA  A 501 (-2.7A)
UGA  A 501 (-4.7A)
None
 1.12A 5dlvB-2y0eA:
undetectable		 5dlvB-2y0eA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 TYR A 583
LYS A 598
TRP A 624
TYR A 522
 None
None
TRS  A 800 (-4.1A)
None
 1.32A 5dlvB-3cihA:
undetectable		 5dlvB-3cihA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01715
(IPPT) 		4 TYR A 114
LYS A 122
HIS A  86
TYR A 164
 A  E  36 ( 3.4A)
U  E  33 ( 4.7A)
G  E  34 ( 4.3A)
U  E  33 ( 4.4A)
 1.47A 5dlvB-3epjA:
undetectable		 5dlvB-3epjA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx9 PROTEIN SCV3V2(G19S)

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 SER A 118
LYS A  34
PHE A  35
HIS A  37
 None
 1.49A 5dlvB-3mx9A:
1.6		 5dlvB-3mx9A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2u METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00753
(Lactamase_B) 		4 SER A  37
TYR A  38
LYS A   4
PHE A   6
 None
 1.40A 5dlvB-3r2uA:
undetectable		 5dlvB-3r2uA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6o POLYSACCHARIDE
DEACETYLASE FAMILY
PROTEIN

(Burkholderia
pseudomallei) 		PF01522
(Polysacc_deac_1) 		4 SER A 187
TYR A 215
PHE A 101
HIS A 263
 None
 1.44A 5dlvB-3s6oA:
undetectable		 5dlvB-3s6oA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 SER A2860
TYR A2874
PHE A2864
HIS A2871
 None
 1.42A 5dlvB-3vkgA:
undetectable		 5dlvB-3vkgA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		4 SER A  58
PHE A  60
TRP A 458
TYR A 293
 B3P  A1560 ( 3.9A)
B3P  A1560 (-4.2A)
None
B3P  A1560 (-4.1A)
 1.31A 5dlvB-3zxlA:
undetectable		 5dlvB-3zxlA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdj NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 123
TYR A 121
LYS A 160
PHE A 132
 None
 1.23A 5dlvB-4gdjA:
undetectable		 5dlvB-4gdjA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00188
(CAP)
PF14504
(CAP_assoc_N) 		4 SER A 106
TYR A  91
PHE A  87
HIS A 216
 EDO  A 401 (-3.4A)
None
EDO  A 401 ( 4.6A)
None
 1.42A 5dlvB-4h0aA:
undetectable		 5dlvB-4h0aA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE

(Rhizomucor
miehei) 		PF03639
(Glyco_hydro_81) 		4 SER A 374
TYR A 376
LYS A 394
PHE A 395
 None
 1.14A 5dlvB-4k35A:
undetectable		 5dlvB-4k35A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		4 TYR A 409
LYS A 495
PHE A 498
HIS A 565
 None
 1.12A 5dlvB-4madA:
undetectable		 5dlvB-4madA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 SER A 227
PHE A 288
HIS A 131
TYR A 315
 None
 1.42A 5dlvB-4tweA:
undetectable		 5dlvB-4tweA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG

(Homo sapiens) 		PF04049
(ANAPC8)
PF13181
(TPR_8)
PF13414
(TPR_11) 		4 SER C 304
TYR C 308
HIS C 347
TYR C 364
 None
 1.50A 5dlvB-4ui9C:
undetectable		 5dlvB-4ui9C:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		4 SER A 443
TYR A 425
PHE A 423
HIS A 482
 None
None
None
MG  A1645 (-3.2A)
 1.12A 5dlvB-4uooA:
15.6		 5dlvB-4uooA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 SER A 305
TYR A 302
HIS A 437
TYR A 467
 None
 1.16A 5dlvB-4uzsA:
undetectable		 5dlvB-4uzsA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 LYS A 249
HIS A 252
TRP A 255
TYR A 307
 4O0  A 908 (-4.0A)
4O0  A 908 (-3.7A)
4O0  A 908 (-3.3A)
NKN  A 909 (-3.6A)
 1.27A 5dlvB-4zg7A:
59.4		 5dlvB-4zg7A:
92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 SER A  82
TYR A  83
LYS A 249
PHE A 250
TRP A 255
 4O0  A 908 ( 2.9A)
None
4O0  A 908 (-4.0A)
4O0  A 908 (-4.5A)
4O0  A 908 (-3.3A)
 0.60A 5dlvB-4zg7A:
59.4		 5dlvB-4zg7A:
92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 TYR A  83
LYS A 249
PHE A 250
HIS A 252
TRP A 255
 None
4O0  A 908 (-4.0A)
4O0  A 908 (-4.5A)
4O0  A 908 (-3.7A)
4O0  A 908 (-3.3A)
 0.81A 5dlvB-4zg7A:
59.4		 5dlvB-4zg7A:
92.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 SER A2780
TYR A2794
PHE A2784
HIS A2791
 None
 1.37A 5dlvB-5nugA:
undetectable		 5dlvB-5nugA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl3 ENGINEERED CHALCONE
ISOMERASE ANCR2

(unidentified) 		no annotation 4 SER A 163
LYS A  92
PHE A 149
HIS A 151
 None
 1.42A 5dlvB-5wl3A:
1.2		 5dlvB-5wl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-) 		no annotation 4 SER A 603
PHE A 607
TRP A 667
TYR A   9
 None
 1.46A 5dlvB-6g3uA:
undetectable		 5dlvB-6g3uA:
undetectable