SIMILAR PATTERNS OF AMINO ACIDS FOR 5DLV_B_5D5B927_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwz PROTEIN
(DIAMINOPIMELATE
EPIMERASE)

(Haemophilus
influenzae) 		PF01678
(DAP_epimerase) 		5 THR A  29
PHE A  25
LEU A  33
ILE A 267
PHE A   3
 None
 1.39A 5dlvB-1bwzA:
undetectable		 5dlvB-1bwzA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hek GAG POLYPROTEIN,
CORE PROTEIN P15

(Equine
infectious
anemia virus) 		PF08723
(Gag_p15) 		5 LEU A  14
THR A  64
LEU A  60
TRP A  51
VAL A  94
 None
 1.26A 5dlvB-1hekA:
undetectable		 5dlvB-1hekA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 THR A 268
PRO A 204
TRP A 255
ILE A 205
VAL A 303
 None
 1.49A 5dlvB-1qf7A:
undetectable		 5dlvB-1qf7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A 433
THR A  65
LEU A  69
ILE A 195
VAL A 441
 None
 1.31A 5dlvB-1v8bA:
undetectable		 5dlvB-1v8bA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		5 ASP A  54
THR A  90
PHE A  91
PRO A 139
TRP A 141
 ZN  A1000 (-2.2A)
ZN  A1000 (-2.4A)
None
None
None
 0.43A 5dlvB-2gsnA:
43.4		 5dlvB-2gsnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		6 THR A  90
PHE A  91
PRO A 139
TRP A 141
TRP A 154
ARG A 183
 ZN  A1000 (-2.4A)
None
None
None
None
None
 1.13A 5dlvB-2gsnA:
43.4		 5dlvB-2gsnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		5 LEU A  94
ASP A 122
THR A 118
PRO A  12
PHE A  87
 None
None
None
FAD  A 501 (-3.6A)
None
 1.32A 5dlvB-2i0zA:
undetectable		 5dlvB-2i0zA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		5 ASP A 309
THR A 282
PHE A 249
LEU A 246
PRO A 255
 None
 1.39A 5dlvB-2imrA:
undetectable		 5dlvB-2imrA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 PHE A 273
LEU A 718
PRO A 669
ILE A 668
ARG A 861
 None
 1.44A 5dlvB-2nz9A:
undetectable		 5dlvB-2nz9A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		5 LEU A  35
PRO A  85
ILE A  84
PHE A  63
VAL A  23
 None
 1.24A 5dlvB-2vk2A:
1.0		 5dlvB-2vk2A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 LEU A 364
LEU A 547
PRO A 510
TRP A 484
ILE A 509
 None
 1.44A 5dlvB-2w1zA:
undetectable		 5dlvB-2w1zA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Brugia malayi) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 518
LEU A 364
PRO A 384
PHE A 523
ARG A 248
 None
 1.43A 5dlvB-2xgtA:
undetectable		 5dlvB-2xgtA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		5 LEU A 178
PHE A 161
TRP A 171
PHE A 173
VAL A  50
 None
 1.36A 5dlvB-3bf8A:
undetectable		 5dlvB-3bf8A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6e BETA-GLUCANASE

(Bacillus
licheniformis) 		PF00722
(Glyco_hydro_16) 		5 THR A  85
PRO A 160
TRP A 138
ILE A 159
VAL A  54
 None
 1.50A 5dlvB-3d6eA:
undetectable		 5dlvB-3d6eA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 LEU B 253
THR B 191
LEU B 202
ILE B 217
PHE B 242
 None
 1.40A 5dlvB-3dw8B:
undetectable		 5dlvB-3dw8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)

(Geobacter
metallireducens) 		no annotation 5 LEU A 363
PHE A 321
LEU A 244
PRO A 317
VAL A 372
 None
 1.42A 5dlvB-3e05A:
undetectable		 5dlvB-3e05A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehe UDP-GLUCOSE
4-EPIMERASE (GALE-1)

(Archaeoglobus
fulgidus) 		PF01370
(Epimerase) 		5 LEU A 185
THR A 257
LEU A 195
ILE A 235
PHE A 181
 None
 1.36A 5dlvB-3eheA:
undetectable		 5dlvB-3eheA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpz GET4 (YOR164C
HOMOLOG)

(Chaetomium
thermophilum) 		PF04190
(DUF410) 		5 LEU A 163
ASP A 174
THR A 178
LEU A 181
ILE A 281
 None
 1.50A 5dlvB-3lpzA:
undetectable		 5dlvB-3lpzA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE

(Actinomadura
kijaniata) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 THR A  53
PHE A  54
LEU A  57
ILE A 128
VAL A 264
 None
 1.35A 5dlvB-3m9vA:
undetectable		 5dlvB-3m9vA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 270
LEU A 361
PRO A 329
ILE A 343
VAL A 263
 None
 1.28A 5dlvB-3mtlA:
undetectable		 5dlvB-3mtlA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ASP A  54
THR A 185
LEU A 221
PRO A 572
ILE A 593
 1CY  A 609 (-2.9A)
1CY  A 609 (-4.3A)
None
None
None
 1.42A 5dlvB-3um6A:
undetectable		 5dlvB-3um6A:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		6 ASP A 200
THR A 238
PHE A 239
PRO A 287
TRP A 289
ARG A 331
 ZN  A1002 ( 2.1A)
ZN  A1002 ( 2.3A)
None
None
None
None
 0.95A 5dlvB-4b56A:
53.6		 5dlvB-4b56A:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		no annotation 5 LEU B 221
THR B  67
LEU B  71
ILE B  93
VAL B 233
 None
 1.32A 5dlvB-4fdgB:
undetectable		 5dlvB-4fdgB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 LEU A  38
ASP A 191
LEU A 201
PRO A 556
VAL A 171
 None
 1.04A 5dlvB-4jsoA:
undetectable		 5dlvB-4jsoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4

(Homo sapiens) 		PF01663
(Phosphodiest) 		6 ASP A  34
THR A  70
PHE A  71
PRO A 118
TRP A 120
ARG A 163
 ZN  A 505 (-2.1A)
ZN  A 505 ( 2.4A)
None
None
None
None
 0.66A 5dlvB-4lr2A:
43.1		 5dlvB-4lr2A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Streptococcus
sanguinis) 		PF00268
(Ribonuc_red_sm) 		5 LEU A 130
ASP A 241
THR A 246
PRO A 168
ILE A 184
 None
 1.13A 5dlvB-4n83A:
undetectable		 5dlvB-4n83A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella suis) 		PF13561
(adh_short_C2) 		5 LEU A  62
THR A 158
PHE A 157
LEU A 154
VAL A 117
 None
 1.47A 5dlvB-4o6vA:
undetectable		 5dlvB-4o6vA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		5 LEU A 297
LEU A  77
PRO A 178
ILE A 238
VAL A 104
 None
 1.50A 5dlvB-4p9nA:
1.8		 5dlvB-4p9nA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus) 		PF03664
(Glyco_hydro_62) 		5 THR A  37
LEU A  40
PRO A  43
ILE A  50
VAL A 306
 None
 1.01A 5dlvB-4pviA:
undetectable		 5dlvB-4pviA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2m BETA-LACTAMASE

(Enterobacter
cloacae) 		PF00905
(Transpeptidase) 		5 LEU A  46
THR A  71
ILE A 204
PHE A 235
VAL A  43
 None
 1.20A 5dlvB-4s2mA:
undetectable		 5dlvB-4s2mA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usp CCL2 LECTIN

(Coprinopsis
cinerea) 		no annotation 5 LEU A  54
ASP A  45
PRO A  84
ILE A 127
VAL A 142
 None
 1.39A 5dlvB-4uspA:
undetectable		 5dlvB-4uspA:
10.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		11 LEU A  79
ASP A 172
THR A 210
PHE A 211
LEU A 214
PRO A 259
TRP A 261
ILE A 262
PHE A 275
TRP A 276
ARG A 285
 None
ZN  A 904 ( 2.2A)
ZN  A 904 ( 2.6A)
NKN  A 909 ( 4.7A)
4O0  A 908 ( 4.4A)
4O0  A 908 ( 4.9A)
4O0  A 908 (-4.4A)
None
4O0  A 908 (-3.7A)
None
None
 0.59A 5dlvB-4zg7A:
59.4		 5dlvB-4zg7A:
92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		6 LEU A  79
PRO A 259
TRP A 261
ILE A 262
TRP A 276
VAL A 279
 None
4O0  A 908 ( 4.9A)
4O0  A 908 (-4.4A)
None
None
GOL  A 910 (-4.1A)
 1.10A 5dlvB-4zg7A:
59.4		 5dlvB-4zg7A:
92.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 LEU B 194
LEU B 183
ILE B 306
PHE B 300
VAL B 394
 None
 1.19A 5dlvB-5cyrB:
undetectable		 5dlvB-5cyrB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		5 LEU A 200
PRO A  54
TRP A 726
PHE A 201
VAL A 246
 None
 1.41A 5dlvB-5e3cA:
undetectable		 5dlvB-5e3cA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 LEU A 428
PRO A 466
ILE A 407
TRP A 415
ARG A 223
 None
 1.25A 5dlvB-5e9aA:
undetectable		 5dlvB-5e9aA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 ASP A  57
THR A 175
PRO A 180
ILE A 198
VAL A  64
 None
 1.49A 5dlvB-5gtmA:
undetectable		 5dlvB-5gtmA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		6 ASP A 147
THR A 185
PHE A 186
PRO A 234
TRP A 236
ARG A 278
 ZN  A 902 (-1.8A)
ZN  A 902 (-2.7A)
None
None
None
None
 0.83A 5dlvB-5gz4A:
52.1		 5dlvB-5gz4A:
46.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 5 ASP E 137
LEU E  92
PRO E  85
ILE E  84
VAL E  41
 None
 1.33A 5dlvB-5h36E:
undetectable		 5dlvB-5h36E:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4u ENDO-BETA-1,4-GLUCAN
ASE

(Cryptopygus
antarcticus) 		PF02015
(Glyco_hydro_45) 		5 LEU A 123
THR A   2
PRO A 194
ILE A 196
VAL A   7
 None
 1.23A 5dlvB-5h4uA:
undetectable		 5dlvB-5h4uA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		5 ASP A 185
THR A 267
PHE A 266
PRO A 172
VAL A 234
 None
 1.35A 5dlvB-5h71A:
undetectable		 5dlvB-5h71A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN ALPHA-1
CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 THR E 319
PHE E 355
LEU E 321
PRO E 329
ILE E 328
 None
 1.44A 5dlvB-5mjsE:
undetectable		 5dlvB-5mjsE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlk ACETYL-COA
CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ASP A 317
PHE A 323
PRO A 115
ILE A 120
VAL A  25
 None
 1.32A 5dlvB-5mlkA:
undetectable		 5dlvB-5mlkA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN
MBTH DOMAIN PROTEIN

(Geobacillus sp.
Y4.1MC1;
Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C)
PF03621
(MbtH) 		5 PRO B  36
TRP B  29
ILE B  35
PHE B   9
ARG A 819
 None
 1.49A 5dlvB-5u89B:
undetectable		 5dlvB-5u89B:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LEU A 271
ASP A 265
THR A 263
ILE A 241
PHE A 269
 QRW  A 601 ( 4.9A)
None
None
None
None
 1.46A 5dlvB-5uuuA:
undetectable		 5dlvB-5uuuA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		6 ASP A  36
THR A  72
PRO A 122
TRP A 124
ILE A 125
ARG A 166
 ZN  A 501 (-2.0A)
ZN  A 501 (-2.4A)
None
None
None
None
 0.73A 5dlvB-5vemA:
44.0		 5dlvB-5vemA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vys GDP-MANNOSE
4,6-DEHYDRATASE /
GDP-4-AMINO-4,6-DIDE
OXY-D-MANNOSE
FORMYLTRANSFERASE

(Brucella
melitensis) 		PF00551
(Formyl_trans_N) 		5 LEU A  96
ASP A 184
THR A   7
VAL A 104
ARG A 137
 None
 1.46A 5dlvB-5vysA:
undetectable		 5dlvB-5vysA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8d AUTOINDUCER SYNTHASE

(Bradyrhizobium
japonicum) 		PF00765
(Autoind_synth) 		5 PHE A  83
LEU A  86
PRO A  93
ILE A  98
TRP A 143
 MTA  A 301 (-4.6A)
None
None
None
GOL  A 302 (-3.5A)
 1.37A 5dlvB-5w8dA:
undetectable		 5dlvB-5w8dA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 5 LEU A1206
ASP A1134
PHE A1224
PRO A1212
VAL A1200
 None
 1.42A 5dlvB-5wblA:
undetectable		 5dlvB-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		5 THR A  66
LEU A  70
PRO A 190
ILE A 162
VAL A 256
 None
None
MG  A 405 (-4.0A)
None
None
 1.46A 5dlvB-5x5hA:
undetectable		 5dlvB-5x5hA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		5 LEU A1069
ASP A1038
LEU A1017
ILE A1461
VAL A1074
 None
 1.37A 5dlvB-5xsyA:
undetectable		 5dlvB-5xsyA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq5 OSTEOMODULIN

(Homo sapiens) 		no annotation 5 LEU A 214
PHE A 156
LEU A 177
PHE A 208
VAL A 186
 None
 1.35A 5dlvB-5yq5A:
undetectable		 5dlvB-5yq5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywz SUN
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 5 THR A 767
LEU A 769
ILE A 727
VAL A 786
ARG A 904
 None
 1.19A 5dlvB-5ywzA:
undetectable		 5dlvB-5ywzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 5 LEU A 151
ASP A 114
LEU A 116
PRO A 131
ILE A 130
 None
 1.49A 5dlvB-5yy8A:
undetectable		 5dlvB-5yy8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 6 ASP A 167
THR A 205
PHE A 206
PRO A 254
TRP A 256
ARG A 298
 ZN  A 902 (-2.0A)
ZN  A 902 (-2.5A)
None
None
None
None
 0.73A 5dlvB-6c01A:
52.2		 5dlvB-6c01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 6 ASP A 168
THR A 206
PHE A 207
PRO A 255
TRP A 257
ARG A 299
 ZN  A1002 (-2.0A)
ZN  A1002 ( 2.5A)
None
None
None
None
 0.83A 5dlvB-6f2tA:
52.3		 5dlvB-6f2tA:
undetectable