SIMILAR PATTERNS OF AMINO ACIDS FOR 5DLV_A_5D5A930_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 SER A 484
TYR A 475
LYS A 359
PHE A 360
 None
 1.28A 5dlvA-1lxtA:
1.4		 5dlvA-1lxtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 SER A 423
TYR A 427
PHE A 559
TRP A 565
 None
 1.33A 5dlvA-2fj0A:
1.4		 5dlvA-2fj0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofs CD59 GLYCOPROTEIN

(Homo sapiens) 		PF00021
(UPAR_LY6) 		4 SER A  20
LYS A  41
PHE A  23
TRP A  40
 None
 1.48A 5dlvA-2ofsA:
undetectable		 5dlvA-2ofsA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 SER A 269
LYS A 331
PHE A 330
TRP A 407
 None
UGA  A 501 (-2.7A)
UGA  A 501 (-4.7A)
None
 1.14A 5dlvA-2y0eA:
0.0		 5dlvA-2y0eA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2u METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00753
(Lactamase_B) 		4 SER A  37
TYR A  38
LYS A   4
PHE A   6
 None
 1.42A 5dlvA-3r2uA:
0.1		 5dlvA-3r2uA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdj NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 123
TYR A 121
LYS A 160
PHE A 132
 None
 1.29A 5dlvA-4gdjA:
1.9		 5dlvA-4gdjA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE

(Rhizomucor
miehei) 		PF03639
(Glyco_hydro_81) 		4 SER A 374
TYR A 376
LYS A 394
PHE A 395
 None
 1.11A 5dlvA-4k35A:
0.8		 5dlvA-4k35A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		4 SER A 132
PHE A 160
TRP A 120
TRP A  64
 None
 1.39A 5dlvA-4lrhA:
undetectable		 5dlvA-4lrhA:
13.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		6 SER A  82
TYR A  83
LYS A 249
PHE A 250
TRP A 255
TRP A 261
 4O0  A 908 ( 2.9A)
None
4O0  A 908 (-4.0A)
4O0  A 908 (-4.5A)
4O0  A 908 (-3.3A)
4O0  A 908 (-4.4A)
 0.53A 5dlvA-4zg7A:
59.4		 5dlvA-4zg7A:
92.72