SIMILAR PATTERNS OF AMINO ACIDS FOR 5DLV_A_5D5A930

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwz PROTEIN
(DIAMINOPIMELATE
EPIMERASE)

(Haemophilus
influenzae) 		PF01678
(DAP_epimerase) 		5 THR A  29
PHE A  25
LEU A  33
ILE A 267
PHE A   3
 None
 1.39A 5dlvA-1bwzA:
undetectable		 5dlvA-1bwzA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		5 LEU A 410
THR A 307
PHE A 385
HIS A 430
ILE A 437
 None
 1.22A 5dlvA-1c7jA:
undetectable		 5dlvA-1c7jA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3b PROTEIN (SMALL
NUCLEAR
RIBONUCLEOPROTEIN SM
D3)

(Homo sapiens) 		PF01423
(LSM) 		5 LEU A  58
THR A  24
ILE A  17
ARG A  54
TYR A  50
 None
None
GOL  A 614 (-4.6A)
None
None
 1.44A 5dlvA-1d3bA:
undetectable		 5dlvA-1d3bA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqp 8-OXOGUANINE DNA
GLYCOSYLASE

(Pyrobaculum
aerophilum) 		PF09171
(AGOG) 		5 THR A 125
LEU A 122
PRO A 213
ARG A 157
TYR A 153
 None
 1.18A 5dlvA-1xqpA:
undetectable		 5dlvA-1xqpA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfz HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Caldanaerobacter
subterraneus) 		PF00156
(Pribosyltran) 		5 PHE A 148
LEU A 131
ILE A  99
PHE A  50
TYR A 158
 None
 1.47A 5dlvA-1yfzA:
undetectable		 5dlvA-1yfzA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		5 THR A  90
PHE A  91
PRO A 139
TRP A 154
ARG A 183
 ZN  A1000 (-2.4A)
None
None
None
None
 1.12A 5dlvA-2gsnA:
43.4		 5dlvA-2gsnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		5 LEU A  94
ASP A 122
THR A 118
PRO A  12
PHE A  87
 None
None
None
FAD  A 501 (-3.6A)
None
 1.34A 5dlvA-2i0zA:
undetectable		 5dlvA-2i0zA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		5 ASP A 309
THR A 282
PHE A 249
LEU A 246
PRO A 255
 None
 1.39A 5dlvA-2imrA:
undetectable		 5dlvA-2imrA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 PHE A 273
LEU A 718
PRO A 669
ILE A 668
ARG A 861
 None
 1.44A 5dlvA-2nz9A:
0.0		 5dlvA-2nz9A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		5 THR A 417
PHE A 404
LEU A 403
ILE A 362
TYR A 389
 None
 1.50A 5dlvA-2qmiA:
undetectable		 5dlvA-2qmiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtg GLOBIN-LIKE PROTEIN

(Caenorhabditis
elegans) 		PF00042
(Globin) 		5 THR A  40
HIS A 101
PHE A  34
ARG A  19
TYR A 121
 None
HEM  A 180 (-3.3A)
None
None
None
 1.44A 5dlvA-2wtgA:
undetectable		 5dlvA-2wtgA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Brugia malayi) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 518
LEU A 364
PRO A 384
PHE A 523
ARG A 248
 None
 1.42A 5dlvA-2xgtA:
undetectable		 5dlvA-2xgtA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 PHE A 149
LEU A 132
ILE A  99
PHE A  51
TYR A 159
 None
 1.44A 5dlvA-3accA:
undetectable		 5dlvA-3accA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		5 ASP A 392
HIS A 297
ILE A 162
PHE A  69
TRP A  68
 None
 1.46A 5dlvA-3axxA:
undetectable		 5dlvA-3axxA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		5 LEU A 454
PHE A 380
LEU A 381
HIS A 469
PRO A 351
 None
 1.32A 5dlvA-3bdlA:
undetectable		 5dlvA-3bdlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber) 		PF01036
(Bac_rhodopsin) 		5 ASP A  96
THR A 100
PRO A 162
ILE A 161
TYR A  94
 None
RET  A1301 ( 4.8A)
None
UNL  A1409 ( 4.9A)
None
 1.23A 5dlvA-3ddlA:
undetectable		 5dlvA-3ddlA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 LEU B 253
THR B 191
LEU B 202
ILE B 217
PHE B 242
 None
 1.39A 5dlvA-3dw8B:
undetectable		 5dlvA-3dw8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 THR A 270
PHE A 271
LEU A 274
HIS A 302
PRO A 250
 None
 1.49A 5dlvA-3h11A:
undetectable		 5dlvA-3h11A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		5 PHE A 146
LEU A 129
ILE A  97
PHE A  48
TYR A 156
 None
 1.49A 5dlvA-3hvuA:
undetectable		 5dlvA-3hvuA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixw HEMOCYANIN AA6 CHAIN

(Androctonus
australis) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 ASP A 563
THR A 455
ILE A 508
ARG A 192
TYR A 588
 None
 1.42A 5dlvA-3ixwA:
undetectable		 5dlvA-3ixwA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpz GET4 (YOR164C
HOMOLOG)

(Chaetomium
thermophilum) 		PF04190
(DUF410) 		5 LEU A 163
ASP A 174
THR A 178
LEU A 181
ILE A 281
 None
 1.49A 5dlvA-3lpzA:
undetectable		 5dlvA-3lpzA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okf 3-DEHYDROQUINATE
SYNTHASE

(Vibrio cholerae) 		PF01761
(DHQ_synthase) 		5 LEU A 174
THR A  45
LEU A 106
ILE A  20
TYR A  53
 None
None
None
None
NAD  A 367 (-4.6A)
 1.00A 5dlvA-3okfA:
2.1		 5dlvA-3okfA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 5 LEU M 132
ILE M 123
PHE M 131
ARG M 273
TYR M 269
 None
 1.37A 5dlvA-3rkoM:
undetectable		 5dlvA-3rkoM:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Thermomonospora
curvata) 		PF10021
(DUF2263) 		5 LEU A 149
THR A 237
PHE A 238
LEU A 241
HIS A 214
 None
 1.24A 5dlvA-3sigA:
undetectable		 5dlvA-3sigA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ASP A  54
THR A 185
LEU A 221
PRO A 572
ILE A 593
 1CY  A 609 (-2.9A)
1CY  A 609 (-4.3A)
None
None
None
 1.43A 5dlvA-3um6A:
undetectable		 5dlvA-3um6A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv1 PROTEIN LEC-6

(Caenorhabditis
elegans) 		PF00337
(Gal-bind_lectin) 		5 LEU A  59
LEU A  38
HIS A 115
PRO A  89
PHE A  61
 None
 1.35A 5dlvA-3vv1A:
undetectable		 5dlvA-3vv1A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		5 ASP A 392
HIS A 297
ILE A 162
PHE A  69
TRP A  68
 None
 1.45A 5dlvA-3w6mA:
undetectable		 5dlvA-3w6mA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE

(Actinidia
chinensis) 		PF01761
(DHQ_synthase) 		5 LEU A 184
THR A  53
LEU A 116
ILE A  27
TYR A  61
 None
None
None
None
NAD  A1381 (-4.5A)
 1.02A 5dlvA-3zokA:
undetectable		 5dlvA-3zokA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ASP A 200
THR A 238
PHE A 239
PRO A 287
ARG A 331
 ZN  A1002 ( 2.1A)
ZN  A1002 ( 2.3A)
None
None
None
 0.95A 5dlvA-4b56A:
53.4		 5dlvA-4b56A:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 ASP A 323
THR A 215
LEU A 217
ILE A 205
TRP A 285
 None
 1.26A 5dlvA-4bbwA:
undetectable		 5dlvA-4bbwA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brz HALOALKANE
DEHALOGENASE

(Rhodobacteraceae) 		PF00561
(Abhydrolase_1) 		5 ASP A 224
THR A 135
ILE A 240
PHE A 113
TYR A 226
 None
 1.43A 5dlvA-4brzA:
undetectable		 5dlvA-4brzA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 LEU A 328
ASP A 476
ILE A 240
PHE A 275
TYR A 477
 None
 1.40A 5dlvA-4cntA:
undetectable		 5dlvA-4cntA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		5 ASP A 319
THR A 207
LEU A 213
PRO A 202
ILE A 201
 None
 1.44A 5dlvA-4fj6A:
undetectable		 5dlvA-4fj6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h43 27.5 KDA VIRULENCE
PROTEIN

(Salmonella
enterica) 		PF03536
(VRP3) 		5 LEU A  33
ASP A 201
PRO A 131
PHE A 235
TYR A 212
 None
 1.41A 5dlvA-4h43A:
undetectable		 5dlvA-4h43A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 ASP A  34
THR A  70
PHE A  71
PRO A 118
ARG A 163
 ZN  A 505 (-2.1A)
ZN  A 505 ( 2.4A)
None
None
None
 0.64A 5dlvA-4lr2A:
43.0		 5dlvA-4lr2A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvk PLASMID
RECOMBINATION ENZYME

(Streptococcus
agalactiae) 		PF01076
(Mob_Pre) 		5 LEU A  46
ASP A  96
PHE A 173
ILE A  84
PHE A 104
 None
 1.48A 5dlvA-4lvkA:
undetectable		 5dlvA-4lvkA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Streptococcus
sanguinis) 		PF00268
(Ribonuc_red_sm) 		5 LEU A 130
ASP A 241
THR A 246
PRO A 168
ILE A 184
 None
 1.14A 5dlvA-4n83A:
undetectable		 5dlvA-4n83A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00156
(Pribosyltran) 		5 PHE A 169
LEU A 152
ILE A 120
PHE A  71
TYR A 179
 PHE  A 169 ( 1.3A)
LEU  A 152 ( 0.6A)
ILE  A 120 ( 0.7A)
PHE  A  71 ( 1.3A)
TYR  A 179 ( 1.3A)
 1.44A 5dlvA-4rhyA:
undetectable		 5dlvA-4rhyA:
13.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		10 LEU A  79
ASP A 172
THR A 210
PHE A 211
LEU A 214
PRO A 259
ILE A 262
PHE A 275
TRP A 276
ARG A 285
 None
ZN  A 904 ( 2.2A)
ZN  A 904 ( 2.6A)
NKN  A 909 ( 4.7A)
4O0  A 908 ( 4.4A)
4O0  A 908 ( 4.9A)
None
4O0  A 908 (-3.7A)
None
None
 0.64A 5dlvA-4zg7A:
59.4		 5dlvA-4zg7A:
92.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8s GUANINE-N7
METHYLTRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		5 THR B 122
LEU B 105
HIS B 268
PRO B 141
PHE B 190
 None
 1.29A 5dlvA-5c8sB:
undetectable		 5dlvA-5c8sB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		5 LEU A 132
PHE A 159
ILE A  60
PHE A  63
TYR A 111
 None
 1.36A 5dlvA-5d2eA:
undetectable		 5dlvA-5d2eA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 LEU A 428
PRO A 466
ILE A 407
TRP A 415
ARG A 223
 None
 1.25A 5dlvA-5e9aA:
undetectable		 5dlvA-5e9aA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9h ISOCITRATE LYASE

(Fusarium
graminearum) 		PF00463
(ICL) 		5 PHE A 437
LEU A 433
ILE A 401
ARG A 454
TYR A 451
 None
 1.39A 5dlvA-5e9hA:
undetectable		 5dlvA-5e9hA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ASP A 147
THR A 185
PHE A 186
HIS A 237
ARG A 278
 ZN  A 902 (-1.8A)
ZN  A 902 (-2.7A)
None
None
None
 1.42A 5dlvA-5gz4A:
52.1		 5dlvA-5gz4A:
46.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ASP A 147
THR A 185
PHE A 186
PRO A 234
ARG A 278
 ZN  A 902 (-1.8A)
ZN  A 902 (-2.7A)
None
None
None
 0.80A 5dlvA-5gz4A:
52.1		 5dlvA-5gz4A:
46.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN ALPHA-1
CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 THR E 319
PHE E 355
LEU E 321
PRO E 329
ILE E 328
 None
 1.44A 5dlvA-5mjsE:
undetectable		 5dlvA-5mjsE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE

(Enterobacter
cloacae) 		PF01977
(UbiD) 		5 LEU A   8
THR A 329
LEU A 330
ILE A 208
ARG A 241
 None
 1.48A 5dlvA-5ny5A:
undetectable		 5dlvA-5ny5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 ASP A  36
THR A  72
PRO A 122
ILE A 125
ARG A 166
 ZN  A 501 (-2.0A)
ZN  A 501 (-2.4A)
None
None
None
 0.68A 5dlvA-5vemA:
44.0		 5dlvA-5vemA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8d AUTOINDUCER SYNTHASE

(Bradyrhizobium
japonicum) 		PF00765
(Autoind_synth) 		5 PHE A  83
LEU A  86
PRO A  93
ILE A  98
TRP A 143
 MTA  A 301 (-4.6A)
None
None
None
GOL  A 302 (-3.5A)
 1.36A 5dlvA-5w8dA:
undetectable		 5dlvA-5w8dA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0c NEROL DEHYDROGENASE

(Persicaria
minor) 		no annotation 5 LEU A 165
HIS A 148
ILE A 100
ARG A 177
TYR A 173
 None
 1.21A 5dlvA-5z0cA:
undetectable		 5dlvA-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 5 ASP A 167
THR A 205
PHE A 206
PRO A 254
ARG A 298
 ZN  A 902 (-2.0A)
ZN  A 902 (-2.5A)
None
None
None
 0.71A 5dlvA-6c01A:
52.3		 5dlvA-6c01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 5 LEU A 297
THR A 238
LEU A 242
ILE A 319
PHE A 313
 None
 1.35A 5dlvA-6cn1A:
undetectable		 5dlvA-6cn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 5 ASP A 168
THR A 206
PHE A 207
PRO A 255
ARG A 299
 ZN  A1002 (-2.0A)
ZN  A1002 ( 2.5A)
None
None
None
 0.80A 5dlvA-6f2tA:
52.2		 5dlvA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 SER A 484
TYR A 475
LYS A 359
PHE A 360
 None
 1.28A 5dlvA-1lxtA:
1.4		 5dlvA-1lxtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 SER A 423
TYR A 427
PHE A 559
TRP A 565
 None
 1.33A 5dlvA-2fj0A:
1.4		 5dlvA-2fj0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofs CD59 GLYCOPROTEIN

(Homo sapiens) 		PF00021
(UPAR_LY6) 		4 SER A  20
LYS A  41
PHE A  23
TRP A  40
 None
 1.48A 5dlvA-2ofsA:
undetectable		 5dlvA-2ofsA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 SER A 269
LYS A 331
PHE A 330
TRP A 407
 None
UGA  A 501 (-2.7A)
UGA  A 501 (-4.7A)
None
 1.14A 5dlvA-2y0eA:
0.0		 5dlvA-2y0eA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2u METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00753
(Lactamase_B) 		4 SER A  37
TYR A  38
LYS A   4
PHE A   6
 None
 1.42A 5dlvA-3r2uA:
0.1		 5dlvA-3r2uA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdj NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 123
TYR A 121
LYS A 160
PHE A 132
 None
 1.29A 5dlvA-4gdjA:
1.9		 5dlvA-4gdjA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE

(Rhizomucor
miehei) 		PF03639
(Glyco_hydro_81) 		4 SER A 374
TYR A 376
LYS A 394
PHE A 395
 None
 1.11A 5dlvA-4k35A:
0.8		 5dlvA-4k35A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		4 SER A 132
PHE A 160
TRP A 120
TRP A  64
 None
 1.39A 5dlvA-4lrhA:
undetectable		 5dlvA-4lrhA:
13.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		6 SER A  82
TYR A  83
LYS A 249
PHE A 250
TRP A 255
TRP A 261
 4O0  A 908 ( 2.9A)
None
4O0  A 908 (-4.0A)
4O0  A 908 (-4.5A)
4O0  A 908 (-3.3A)
4O0  A 908 (-4.4A)
 0.53A 5dlvA-4zg7A:
59.4		 5dlvA-4zg7A:
92.72