SIMILAR PATTERNS OF AMINO ACIDS FOR 5DL9_A_ACTA214

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahs AFRICAN HORSE
SICKNESS VIRUS
(SEROTYPE 4) VP7

(African horse
sickness virus) 		PF00897
(Orbi_VP7) 		4 ASP A 213
TRP A 225
VAL A 223
ALA A 224
 None
 1.43A 5dl9A-1ahsA:
undetectable		 5dl9A-1ahsA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 GLU A  44
ASP A  45
VAL A  16
ALA A  17
 None
 1.33A 5dl9A-1cvrA:
undetectable		 5dl9A-1cvrA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE

(Homo sapiens) 		PF01916
(DS) 		4 ASP A 138
TRP A 223
VAL A 120
ALA A 224
 None
 1.49A 5dl9A-1dhsA:
undetectable		 5dl9A-1dhsA:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1di4 LYSOZYME C

(Homo sapiens) 		PF00062
(Lys) 		5 GLU A  35
ASP A  53
TRP A 109
VAL A 110
ALA A 111
 None
 0.73A 5dl9A-1di4A:
25.1		 5dl9A-1di4A:
60.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		4 GLU A  10
ASP A 120
VAL A  30
ALA A  15
 None
 1.32A 5dl9A-1j71A:
undetectable		 5dl9A-1j71A:
17.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jug LYSOZYME

(Tachyglossus
aculeatus) 		PF00062
(Lys) 		5 GLU A  35
ASP A  52
TRP A 108
VAL A 109
ALA A 110
 None
 0.65A 5dl9A-1jugA:
22.9		 5dl9A-1jugA:
52.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lhu SEX HORMONE-BINDING
GLOBULIN

(Homo sapiens) 		PF00054
(Laminin_G_1) 		4 ASP A  65
TRP A  84
VAL A 127
ALA A  85
 EST  A 301 (-2.9A)
None
None
None
 1.16A 5dl9A-1lhuA:
undetectable		 5dl9A-1lhuA:
19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lmo LYSOZYME

(Oncorhynchus
mykiss) 		PF00062
(Lys) 		5 GLU A  35
ASP A  52
TRP A 108
VAL A 109
ALA A 110
 None
NAG  A 131 ( 4.5A)
NAG  A 131 (-3.7A)
None
None
 0.60A 5dl9A-1lmoA:
25.9		 5dl9A-1lmoA:
60.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qp8 FORMATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLU A 213
ASP A  62
VAL A 214
ALA A 212
 None
 1.44A 5dl9A-1qp8A:
undetectable		 5dl9A-1qp8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq4 GLYOXYLATE-INDUCED
PROTEIN

(Pseudomonas
aeruginosa) 		PF07883
(Cupin_2) 		4 GLU A 213
ASP A 265
VAL A 211
ALA A 244
 None
 1.37A 5dl9A-1sq4A:
undetectable		 5dl9A-1sq4A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk8 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus cereus) 		PF13305
(WHG) 		4 GLU A  89
ASP A 167
VAL A  92
ALA A  93
 None
 1.44A 5dl9A-1zk8A:
undetectable		 5dl9A-1zk8A:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eql HORSE MILK LYSOZYME

(Equus caballus) 		PF00062
(Lys) 		4 GLU A  35
ASP A  53
TRP A 108
ALA A 110
 None
 0.63A 5dl9A-2eqlA:
22.5		 5dl9A-2eqlA:
49.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gv0 LYSOZYME C

(Pelodiscus
sinensis) 		PF00062
(Lys) 		5 GLU A  36
ASP A  54
TRP A 110
VAL A 111
ALA A 112
 None
 0.54A 5dl9A-2gv0A:
25.5		 5dl9A-2gv0A:
68.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE

(Thermus
thermophilus) 		PF01370
(Epimerase) 		4 GLU A 183
ASP A 274
VAL A 186
ALA A 184
 None
None
None
NAD  A1118 (-3.2A)
 1.47A 5dl9A-2p5uA:
undetectable		 5dl9A-2p5uA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		4 GLU A 262
ASP A 231
VAL A 255
ALA A 258
 None
 1.12A 5dl9A-2p6pA:
undetectable		 5dl9A-2p6pA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Aspergillus
oryzae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  52
ASP A 302
VAL A  14
ALA A  36
 None
 1.29A 5dl9A-2ps2A:
undetectable		 5dl9A-2ps2A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		4 GLU A 533
ASP A  76
VAL A  82
ALA A  81
 None
 1.15A 5dl9A-2qqpA:
undetectable		 5dl9A-2qqpA:
12.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2e LYSOZYME C, MILK
ISOZYME

(Canis lupus) 		PF00062
(Lys) 		5 GLU A  35
ASP A  53
TRP A 108
VAL A 109
ALA A 110
 None
 0.70A 5dl9A-2z2eA:
22.8		 5dl9A-2z2eA:
50.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z2f LYSOZYME C-2

(Bos taurus) 		PF00062
(Lys) 		5 GLU A  35
ASP A  53
TRP A 108
VAL A 109
ALA A 110
 None
 0.32A 5dl9A-2z2fA:
25.6		 5dl9A-2z2fA:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		4 GLU A  73
ASP A  51
VAL A  56
ALA A  78
 None
 1.47A 5dl9A-2zwvA:
undetectable		 5dl9A-2zwvA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 ASP A 168
TRP A 200
VAL A 191
ALA A 192
 None
 1.36A 5dl9A-3a0fA:
undetectable		 5dl9A-3a0fA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00196
(GerE) 		4 GLU A  38
ASP A  59
VAL A   7
ALA A  33
 None
 1.40A 5dl9A-3c3wA:
undetectable		 5dl9A-3c3wA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		4 ASP A 388
TRP A 380
VAL A 383
ALA A 382
 None
 1.41A 5dl9A-3clwA:
undetectable		 5dl9A-3clwA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLU A  78
ASP A  83
VAL A  42
ALA A  43
 None
 1.50A 5dl9A-3dtyA:
undetectable		 5dl9A-3dtyA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF13419
(HAD_2) 		4 ASP A 115
TRP A 129
VAL A 126
ALA A 127
 CA  A   4 (-4.7A)
None
None
None
 1.35A 5dl9A-3s6jA:
undetectable		 5dl9A-3s6jA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(uncultured
archaeon) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 GLU B 423
ASP B  10
VAL B 199
ALA B 422
 None
 1.44A 5dl9A-3sqgB:
undetectable		 5dl9A-3sqgB:
14.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zvq LYSOZYME C
LYSOZYME C

(Gallus gallus;
Gallus gallus) 		PF00062
(Lys)
PF00062
(Lys) 		5 GLU A  35
ASP A  52
TRP B 108
VAL B 109
ALA B 110
 None
 0.65A 5dl9A-3zvqA:
10.5		 5dl9A-3zvqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 ASP A 691
TRP A 690
VAL A 720
ALA A 719
 MG  A1771 ( 2.7A)
None
None
None
 1.09A 5dl9A-4a01A:
undetectable		 5dl9A-4a01A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ASP A 386
TRP A 388
VAL A 392
ALA A 391
 None
 1.35A 5dl9A-4cokA:
undetectable		 5dl9A-4cokA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efh ACTIN-1

(Acanthamoeba
castellanii) 		PF00022
(Actin) 		4 GLU A  93
ASP A  56
VAL A  30
ALA A  29
 None
 1.46A 5dl9A-4efhA:
undetectable		 5dl9A-4efhA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iel GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF13417
(GST_N_3) 		4 ASP A  98
TRP A  96
VAL A  93
ALA A 161
 None
 1.46A 5dl9A-4ielA:
undetectable		 5dl9A-4ielA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ASP A1426
TRP A1377
VAL A1386
ALA A1394
 None
 1.30A 5dl9A-4iglA:
undetectable		 5dl9A-4iglA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR

(Parabacteroides
distasonis) 		PF04773
(FecR)
PF16344
(DUF4974) 		4 ASP A 278
TRP A 260
VAL A 257
ALA A 259
 None
 1.17A 5dl9A-4m0hA:
undetectable		 5dl9A-4m0hA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		4 GLU A 213
ASP A 131
VAL A 278
ALA A 277
 None
 1.16A 5dl9A-4s28A:
undetectable		 5dl9A-4s28A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usc PEROXIDASE

(Trachycarpus
fortunei) 		PF00141
(peroxidase) 		4 GLU A 274
ASP A 160
TRP A 271
ALA A 270
 None
None
None
NAG  A1311 (-3.2A)
 1.45A 5dl9A-4uscA:
undetectable		 5dl9A-4uscA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wg1 LYSOZYME C

(Gallus gallus) 		PF00062
(Lys) 		5 GLU A  35
ASP A  52
TRP A 108
VAL A 109
ALA A 110
 None
None
CL  A 201 ( 4.3A)
None
None
 0.62A 5dl9A-4wg1A:
27.9		 5dl9A-4wg1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 ASP A 193
TRP A 164
VAL A 163
ALA A 226
 None
 1.49A 5dl9A-5a5gA:
undetectable		 5dl9A-5a5gA:
10.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jen LYSOZYME C

(Gallus gallus) 		PF00062
(Lys) 		5 GLU B  35
ASP B  52
TRP B 108
VAL B 109
ALA B 110
 NA  A 401 ( 4.2A)
NA  A 401 (-3.1A)
None
None
None
 0.52A 5dl9A-5jenB:
26.7		 5dl9A-5jenB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7v GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus) 		PF13320
(DUF4091) 		4 GLU A  60
TRP A  57
VAL A 188
ALA A  56
 None
 1.49A 5dl9A-5l7vA:
undetectable		 5dl9A-5l7vA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8o MITOCHONDRIAL IMPORT
RECEPTOR SUBUNIT
TOM40

(Neurospora
crassa) 		PF01459
(Porin_3) 		4 GLU A 329
ASP A 332
VAL A  81
ALA A  72
 None
 1.12A 5dl9A-5o8oA:
undetectable		 5dl9A-5o8oA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 GLU T1261
ASP T1258
VAL T1303
ALA T1306
 None
 1.42A 5dl9A-5ojsT:
undetectable		 5dl9A-5ojsT:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 ASP p  88
TRP p  87
VAL p 112
ALA p  85
 None
 1.34A 5dl9A-5optp:
undetectable		 5dl9A-5optp:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v8g LYSOZYME ISOFORM I

(Anas
platyrhynchos) 		no annotation 5 GLU A  35
ASP A  52
TRP A 108
VAL A 109
ALA A 110
 None
 0.62A 5dl9A-5v8gA:
26.5		 5dl9A-5v8gA:
84.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 2,
MITOCHONDRIAL

(Homo sapiens) 		PF01257
(2Fe-2S_thioredx) 		4 GLU O 194
ASP O 195
VAL O 181
ALA O 179
 None
 1.37A 5dl9A-5xtbO:
undetectable		 5dl9A-5xtbO:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 4 GLU A 323
ASP A 325
VAL A 338
ALA A 341
 None
ZN  A 901 ( 2.1A)
None
None
 1.48A 5dl9A-6c01A:
undetectable		 5dl9A-6c01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 4 GLU A 396
ASP A 397
VAL A 312
ALA A 311
 None
 1.48A 5dl9A-6cxhA:
undetectable		 5dl9A-6cxhA:
undetectable