SIMILAR PATTERNS OF AMINO ACIDS FOR 5DBY_A_ACTA612

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 SER A 582
HIS A 580
GLU A 592
PRO A 579
 None
 1.37A 5dbyA-1uaaA:
0.2		 5dbyA-1uaaA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qts ACID-SENSING ION
CHANNEL

(Gallus gallus) 		PF00858
(ASC) 		4 SER A 252
HIS A 251
GLU A 255
PRO A 256
 NAG  A   1 ( 4.0A)
None
None
None
 1.46A 5dbyA-2qtsA:
2.9		 5dbyA-2qtsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpi GMP SYNTHASE

(Homo sapiens) 		PF00117
(GATase) 		4 SER A  75
HIS A 190
GLU A 192
PRO A 191
 None
 1.42A 5dbyA-2vpiA:
0.0		 5dbyA-2vpiA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 SER A1022
HIS A1013
GLU A1170
PRO A1171
 None
 1.29A 5dbyA-2xt6A:
1.1		 5dbyA-2xt6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 SER A1022
HIS A1013
GLU A1170
PRO A1171
 None
 1.28A 5dbyA-3zhrA:
0.8		 5dbyA-3zhrA:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 SER A  65
HIS A  67
GLU A  95
PRO A  96
 None
 0.59A 5dbyA-4po0A:
50.3		 5dbyA-4po0A:
71.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 SER A  65
HIS A  67
GLU A  95
PRO A  96
 None
 0.39A 5dbyA-5dqfA:
54.7		 5dbyA-5dqfA:
99.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 4 SER A  65
HIS A  67
GLU A  95
PRO A  96
 None
 0.86A 5dbyA-5oriA:
51.3		 5dbyA-5oriA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gk6 -

(-) 		no annotation 4 SER A  15
HIS A  12
GLU A   9
PRO A   8
 None
 1.47A 5dbyA-6gk6A:
0.0		 5dbyA-6gk6A:
undetectable