SIMILAR PATTERNS OF AMINO ACIDS FOR 5DBY_A_ACTA611

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)

(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9)
PF02256
(Fe_hyd_SSU) 		4 LYS A 201
SER A 248
LEU D  87
ALA A 209
 None
 1.12A 5dbyA-1e08A:
0.0		 5dbyA-1e08A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 LYS A  17
SER A  31
LEU A  30
ALA A 338
 None
 0.90A 5dbyA-2douA:
0.0		 5dbyA-2douA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LYS A 216
SER A 230
LEU A 228
ALA A 227
 None
 1.23A 5dbyA-3u9sA:
0.0		 5dbyA-3u9sA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		4 LYS A 513
SER A 439
LEU A 440
ALA A 441
 None
 0.80A 5dbyA-5dgkA:
1.8		 5dbyA-5dgkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kz5 FRATAXIN,
MITOCHONDRIAL
IRON-SULFUR CLUSTER
ASSEMBLY ENZYME
ISCU, MITOCHONDRIAL

(Homo sapiens;
Homo sapiens) 		PF01491
(Frataxin_Cyay)
PF01491
(Frataxin_Cyay) 		4 LYS a 127
SER A 201
LEU A 200
ALA A 187
 None
 1.16A 5dbyA-5kz5a:
0.0		 5dbyA-5kz5a:
12.26