SIMILAR PATTERNS OF AMINO ACIDS FOR 5DBY_A_ACTA610_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cit PROTEIN (ORPHAN
NUCLEAR RECEPTOR
NGFI-B)

(Rattus
norvegicus) 		PF00105
(zf-C4) 		3 TYR A 244
LYS A 257
LYS A 253
 None
 0.84A 5dbyA-1citA:
undetectable		 5dbyA-1citA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6f PROLACTIN RECEPTOR

(Rattus
norvegicus) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		3 TYR B  75
LYS B  73
LYS B  42
 None
 1.23A 5dbyA-1f6fB:
undetectable		 5dbyA-1f6fB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME ALPHA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 TYR A 149
LYS A 114
LYS A 110
 None
 1.28A 5dbyA-1j2qA:
1.0		 5dbyA-1j2qA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo1 STEROID HORMONE
RECEPTOR ERR2

(Homo sapiens) 		PF00105
(zf-C4) 		3 TYR A 115
LYS A 128
LYS A 124
 None
 1.20A 5dbyA-1lo1A:
undetectable		 5dbyA-1lo1A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN GAMMA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 TYR C 348
LYS C 381
LYS C 380
 None
 1.17A 5dbyA-1m1jC:
undetectable		 5dbyA-1m1jC:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pww LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		3 TYR A  82
LYS A  80
LYS A  45
 None
 1.06A 5dbyA-1pwwA:
0.0		 5dbyA-1pwwA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0u PROTEIN YWIB

(Bacillus
subtilis) 		PF09148
(DUF1934) 		3 TYR A  40
LYS A  38
LYS A  57
 None
 1.05A 5dbyA-1r0uA:
undetectable		 5dbyA-1r0uA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8n KUNITZ TRYPSIN
INHIBITOR

(Delonix regia) 		PF00197
(Kunitz_legume) 		3 TYR A  74
LYS A  72
LYS A   5
 None
 1.31A 5dbyA-1r8nA:
undetectable		 5dbyA-1r8nA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 TYR A 543
LYS A 438
LYS A 441
 None
 1.10A 5dbyA-1r8wA:
0.0		 5dbyA-1r8wA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8h PHOSPHOLIPASE A2
HOMOLOG

(Agkistrodon
contortrix) 		PF00068
(Phospholip_A2_1) 		3 TYR A  52
LYS A  53
LYS A  49
 None
SO4  A 134 (-3.3A)
SO4  A 134 (-2.5A)
 1.17A 5dbyA-1s8hA:
undetectable		 5dbyA-1s8hA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8h PHOSPHOLIPASE A2
HOMOLOG

(Agkistrodon
contortrix) 		PF00068
(Phospholip_A2_1) 		3 TYR A 113
LYS A 118
LYS A 115
 None
 1.14A 5dbyA-1s8hA:
undetectable		 5dbyA-1s8hA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sie POLYOMAVIRUS COAT
PROTEIN VP1

(Mus musculus
polyomavirus 1) 		PF00718
(Polyoma_coat) 		3 TYR A 305
LYS A 307
LYS A 126
 None
 1.22A 5dbyA-1sieA:
undetectable		 5dbyA-1sieA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		3 TYR A 333
LYS A 319
LYS A 334
 None
 1.29A 5dbyA-1tp7A:
0.3		 5dbyA-1tp7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		3 TYR A 333
LYS A 319
LYS A 334
 None
 1.19A 5dbyA-1xr6A:
0.0		 5dbyA-1xr6A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtz RIBOSE-5-PHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF06026
(Rib_5-P_isom_A) 		3 TYR A  52
LYS A  19
LYS A  22
 None
 0.93A 5dbyA-1xtzA:
undetectable		 5dbyA-1xtzA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycp EPSILON THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		3 TYR K  89
LYS K 107
LYS K  87
 None
 1.10A 5dbyA-1ycpK:
undetectable		 5dbyA-1ycpK:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynw RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00105
(zf-C4) 		3 TYR B 247
LYS B 260
LYS B 256
 None
 0.89A 5dbyA-1ynwB:
undetectable		 5dbyA-1ynwB:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx3 HYPOTHETICAL PROTEIN
DSRC

(Allochromatium
vinosum) 		PF04358
(DsrC) 		3 TYR A  19
LYS A  97
LYS A 107
 None
 1.23A 5dbyA-1yx3A:
undetectable		 5dbyA-1yx3A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		3 TYR A 768
LYS A 756
LYS A 758
 None
 1.33A 5dbyA-1z26A:
0.0		 5dbyA-1z26A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 TYR A 681
LYS A 677
LYS A 680
 None
 1.36A 5dbyA-1zcjA:
undetectable		 5dbyA-1zcjA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		3 TYR A 302
LYS A 255
LYS A 300
 None
 1.19A 5dbyA-2bi7A:
undetectable		 5dbyA-2bi7A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eey MOLYBDOPTERIN
BIOSYNTHESIS

(Geobacillus
kaustophilus) 		PF01967
(MoaC) 		3 TYR A 129
LYS A 137
LYS A 133
 None
 0.99A 5dbyA-2eeyA:
2.3		 5dbyA-2eeyA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej9 PUTATIVE BIOTIN
LIGASE

(Methanocaldococcus
jannaschii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		3 TYR A 118
LYS A  21
LYS A  17
 None
 0.70A 5dbyA-2ej9A:
undetectable		 5dbyA-2ej9A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ff0 STEROIDOGENIC FACTOR
1

(Mus musculus) 		PF00105
(zf-C4) 		3 TYR A  25
LYS A  38
LYS A  34
 TYR  A  25 ( 1.3A)
LYS  A  38 ( 0.0A)
LYS  A  34 ( 0.0A)
 0.98A 5dbyA-2ff0A:
undetectable		 5dbyA-2ff0A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gan 182AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF00583
(Acetyltransf_1) 		3 TYR A  72
LYS A   1
LYS A  74
 None
None
SO4  A1203 (-2.8A)
 1.25A 5dbyA-2ganA:
undetectable		 5dbyA-2ganA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER

(Bacillus
subtilis) 		PF07470
(Glyco_hydro_88) 		3 TYR A 295
LYS A 289
LYS A 293
 None
 1.32A 5dbyA-2gh4A:
undetectable		 5dbyA-2gh4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk3 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07090
(GATase1_like) 		3 TYR A 212
LYS A 113
LYS A 109
 None
 1.26A 5dbyA-2gk3A:
undetectable		 5dbyA-2gk3A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 TYR A 127
LYS A  69
LYS A  65
 None
 0.95A 5dbyA-2gksA:
undetectable		 5dbyA-2gksA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 TYR A 155
LYS A 201
LYS A 197
 None
 1.13A 5dbyA-2i80A:
undetectable		 5dbyA-2i80A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jm1 TRANSCRIPTIONAL
REGULATOR ATRX

(Homo sapiens) 		no annotation 3 TYR A 187
LYS A 202
LYS A 198
 None
 0.98A 5dbyA-2jm1A:
undetectable		 5dbyA-2jm1A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfk BUD EMERGENCE
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00564
(PB1) 		3 TYR A  11
LYS A  72
LYS A   9
 None
 1.19A 5dbyA-2kfkA:
undetectable		 5dbyA-2kfkA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mdr DOUBLE-STRANDED
RNA-SPECIFIC
ADENOSINE DEAMINASE

(Homo sapiens) 		PF00035
(dsrm) 		3 TYR A 760
LYS A 781
LYS A 777
 None
 1.12A 5dbyA-2mdrA:
undetectable		 5dbyA-2mdrA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ncg RGA1E

(Aegilops
tauschii) 		no annotation 3 TYR A  23
LYS A  30
LYS A  27
 None
 1.09A 5dbyA-2ncgA:
undetectable		 5dbyA-2ncgA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nll PROTEIN (RETINOIC
ACID RECEPTOR)

(Homo sapiens) 		PF00105
(zf-C4) 		3 TYR A 147
LYS A 160
LYS A 156
 None
 0.53A 5dbyA-2nllA:
undetectable		 5dbyA-2nllA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		3 TYR A 480
LYS A  60
LYS A 478
 None
 1.18A 5dbyA-2pggA:
4.0		 5dbyA-2pggA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 TYR A 538
LYS A 592
LYS A 591
 None
SO4  A1781 (-3.4A)
SO4  A1781 (-3.3A)
 1.28A 5dbyA-2vwkA:
undetectable		 5dbyA-2vwkA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w81 COMPLEMENT FACTOR H

(Homo sapiens) 		PF00084
(Sushi) 		3 TYR A 390
LYS A 388
LYS A 405
 None
 1.18A 5dbyA-2w81A:
undetectable		 5dbyA-2w81A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		3 TYR A 174
LYS A 172
LYS A 184
 None
 1.34A 5dbyA-2w8iA:
undetectable		 5dbyA-2w8iA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		3 TYR A 234
LYS A 120
LYS A 121
 None
SO4  A 405 (-4.4A)
None
 1.35A 5dbyA-2y4fA:
undetectable		 5dbyA-2y4fA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09110
(HAND)
PF09111
(SLIDE)
PF15612
(WHIM1) 		3 TYR A1007
LYS A1006
LYS B 327
 None
 1.35A 5dbyA-2y9yA:
3.0		 5dbyA-2y9yA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynx LACA THIOREDOXIN

(synthetic
construct) 		PF00085
(Thioredoxin) 		3 TYR A  47
LYS A 102
LYS A  98
 None
 0.89A 5dbyA-2ynxA:
undetectable		 5dbyA-2ynxA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywq RIBOSOMAL SUBUNIT
INTERFACE PROTEIN

(Thermus
thermophilus) 		PF02482
(Ribosomal_S30AE) 		3 TYR A   4
LYS A   5
LYS A  39
 None
 1.35A 5dbyA-2ywqA:
undetectable		 5dbyA-2ywqA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 TYR B  77
LYS B  74
LYS B  70
 None
 0.90A 5dbyA-3ayxB:
undetectable		 5dbyA-3ayxB:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bew MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B21

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A 253
LYS A 252
LYS A 215
 None
 1.16A 5dbyA-3bewA:
undetectable		 5dbyA-3bewA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 TYR C 348
LYS C 381
LYS C 380
 None
 1.18A 5dbyA-3bvhC:
undetectable		 5dbyA-3bvhC:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		3 TYR A 242
LYS A 236
LYS A 232
 None
 1.15A 5dbyA-3cg3A:
undetectable		 5dbyA-3cg3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do8 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01467
(CTP_transf_like) 		3 TYR A  79
LYS A 102
LYS A 106
 None
 1.13A 5dbyA-3do8A:
undetectable		 5dbyA-3do8A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 TYR A 147
LYS A 160
LYS A 156
 None
 1.10A 5dbyA-3dzuA:
undetectable		 5dbyA-3dzuA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi9 MALATE DEHYDROGENASE

(Porphyromonas
gingivalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TYR A  77
LYS A  76
LYS A 118
 None
 1.32A 5dbyA-3fi9A:
undetectable		 5dbyA-3fi9A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fib FIBRINOGEN GAMMA
CHAIN RESIDUES

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		3 TYR A 348
LYS A 381
LYS A 380
 None
 1.08A 5dbyA-3fibA:
undetectable		 5dbyA-3fibA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		3 TYR A  42
LYS A  38
LYS A  41
 None
 1.31A 5dbyA-3hhrA:
undetectable		 5dbyA-3hhrA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7o RIBOSE-5-PHOSPHATE
ISOMERASE A

(Streptococcus
mutans) 		PF06026
(Rib_5-P_isom_A) 		3 TYR A  32
LYS A   2
LYS A   5
 None
 0.95A 5dbyA-3l7oA:
undetectable		 5dbyA-3l7oA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llq AQUAPORIN Z 2

(Agrobacterium
fabrum) 		PF00230
(MIP) 		3 TYR A  84
LYS A   1
LYS A   4
 None
 1.25A 5dbyA-3llqA:
undetectable		 5dbyA-3llqA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 TYR A 493
LYS A 495
LYS A 467
 None
 1.29A 5dbyA-3ngoA:
undetectable		 5dbyA-3ngoA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0h INACTIVATION-NO-AFTE
R-POTENTIAL D
PROTEIN

(Drosophila
melanogaster) 		PF00595
(PDZ) 		3 TYR A 616
LYS A 590
LYS A 593
 None
 1.11A 5dbyA-3r0hA:
undetectable		 5dbyA-3r0hA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgq HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 TYR A 486
LYS A 485
LYS A 227
 None
 1.22A 5dbyA-3tgqA:
undetectable		 5dbyA-3tgqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmr UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
vulgatus) 		PF14734
(DUF4469)
PF14848
(HU-DNA_bdg) 		3 TYR A 132
LYS A 159
LYS A 130
 None
 1.28A 5dbyA-4fmrA:
undetectable		 5dbyA-4fmrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g43 MHC CLASS I ALPHA
CHAIN 2

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A 253
LYS A 252
LYS A 215
 None
 1.21A 5dbyA-4g43A:
undetectable		 5dbyA-4g43A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		3 TYR A 155
LYS A 157
LYS A 136
 None
 0.79A 5dbyA-4j5tA:
undetectable		 5dbyA-4j5tA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lss ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 TYR G 486
LYS G 485
LYS G 227
 None
 1.19A 5dbyA-4lssG:
undetectable		 5dbyA-4lssG:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mu9 GLYCOSIDE HYDROLASE
FAMILY 73

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		3 TYR A  93
LYS A 102
LYS A  99
 None
 1.19A 5dbyA-4mu9A:
undetectable		 5dbyA-4mu9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		3 TYR A 173
LYS A 167
LYS A 169
 None
 0.91A 5dbyA-4oetA:
undetectable		 5dbyA-4oetA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oln ANCSR1

(synthetic
construct) 		PF00105
(zf-C4) 		3 TYR A  19
LYS A  32
LYS A  28
 None
 0.71A 5dbyA-4olnA:
undetectable		 5dbyA-4olnA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Bacillus
anthracis) 		PF00588
(SpoU_methylase) 		3 TYR A  99
LYS A  94
LYS A  97
 None
 1.32A 5dbyA-4pzkA:
undetectable		 5dbyA-4pzkA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 TYR A 331
LYS A 425
LYS A 421
 None
 1.12A 5dbyA-4q6rA:
undetectable		 5dbyA-4q6rA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)

(Clostridium
acetobutylicum) 		PF07470
(Glyco_hydro_88) 		3 TYR A 358
LYS A 296
LYS A 292
 None
 1.14A 5dbyA-4wu0A:
undetectable		 5dbyA-4wu0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvs DONOR 45 01DG5 COREE
GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 TYR G 487
LYS G 486
LYS G 227
 None
 1.31A 5dbyA-4xvsG:
undetectable		 5dbyA-4xvsG:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye4 HT593.1 GP120

(Human
immunodeficiency
virus) 		PF00516
(GP120) 		3 TYR G 488
LYS G 487
LYS G 227
 None
 1.28A 5dbyA-4ye4G:
undetectable		 5dbyA-4ye4G:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7x HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 TYR A 486
LYS A 485
LYS A 227
 None
 1.33A 5dbyA-5a7xA:
undetectable		 5dbyA-5a7xA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		3 TYR J 332
LYS J 329
LYS J 331
 None
 1.34A 5dbyA-5afuJ:
0.5		 5dbyA-5afuJ:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE

(Serratia
marcescens) 		PF00753
(Lactamase_B) 		3 TYR A  15
LYS A 166
LYS A 168
 None
 1.25A 5dbyA-5b1uA:
undetectable		 5dbyA-5b1uA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2m PREDICTED PROTEIN

(Nematostella
vectensis) 		PF14517
(Tachylectin) 		3 TYR A 160
LYS A 158
LYS A 169
 None
 0.95A 5dbyA-5c2mA:
undetectable		 5dbyA-5c2mA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch6 FRIGIDA

(Vitis vinifera) 		PF07899
(Frigida) 		3 TYR A 346
LYS A 328
LYS A 324
 None
 1.23A 5dbyA-5ch6A:
undetectable		 5dbyA-5ch6A:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		3 TYR A 496
LYS A 499
LYS A 533
 None
SO4  A 611 (-3.0A)
SO4  A 611 (-2.7A)
 0.14A 5dbyA-5dqfA:
54.7		 5dbyA-5dqfA:
99.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		3 TYR A 360
LYS A  33
LYS A  29
 None
 1.23A 5dbyA-5ecoA:
undetectable		 5dbyA-5ecoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejh NAD KINASE 1

(Listeria
monocytogenes) 		PF01513
(NAD_kinase) 		3 TYR A  27
LYS A  92
LYS A  88
 None
 1.23A 5dbyA-5ejhA:
undetectable		 5dbyA-5ejhA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 TYR A 206
LYS A 231
LYS A 208
 None
 1.13A 5dbyA-5fr8A:
undetectable		 5dbyA-5fr8A:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		3 TYR A 497
LYS A 500
LYS A 534
 None
 0.84A 5dbyA-5ghkA:
47.6		 5dbyA-5ghkA:
76.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 TYR A 178
LYS A 176
LYS A 189
 None
 1.04A 5dbyA-5gjeA:
undetectable		 5dbyA-5gjeA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpy GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1

(Homo sapiens) 		PF02002
(TFIIE_alpha)
PF08271
(TF_Zn_Ribbon) 		3 TYR A  96
LYS A  15
LYS A  10
 None
 1.16A 5dbyA-5gpyA:
undetectable		 5dbyA-5gpyA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm7 BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		3 TYR A 366
LYS A 304
LYS A 303
 None
 1.12A 5dbyA-5hm7A:
undetectable		 5dbyA-5hm7A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		3 TYR A 335
LYS A 320
LYS A 333
 None
 1.15A 5dbyA-5iheA:
undetectable		 5dbyA-5iheA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		3 TYR A 497
LYS A 549
LYS A 495
 None
 1.24A 5dbyA-5ihwA:
undetectable		 5dbyA-5ihwA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6o PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		3 TYR A2102
LYS A2111
LYS A2100
 None
 1.21A 5dbyA-5j6oA:
undetectable		 5dbyA-5j6oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1

(Staphylococcus
aureus) 		no annotation 3 TYR B  21
LYS B  19
LYS B  12
 None
 1.36A 5dbyA-5k59B:
undetectable		 5dbyA-5k59B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN

(Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16) 		3 TYR A 352
LYS A 366
LYS A 368
 None
 1.34A 5dbyA-5nnpA:
undetectable		 5dbyA-5nnpA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 3 TYR A 229
LYS A 265
LYS A 269
 None
NAP  A 502 (-3.9A)
NAP  A 502 (-2.9A)
 1.34A 5dbyA-5o8rA:
undetectable		 5dbyA-5o8rA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 3 TYR A 496
LYS A 499
LYS A 533
 None
 0.44A 5dbyA-5oriA:
51.3		 5dbyA-5oriA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3b GLYCOSIDE HYDROLASE

(Bacteroides
plebeius) 		no annotation 3 TYR A 369
LYS A 417
LYS A 426
 EDO  A 505 (-4.6A)
None
EDO  A 505 ( 4.1A)
 1.31A 5dbyA-5t3bA:
undetectable		 5dbyA-5t3bA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te4 HIV-1 CLADE G STRAIN
X2088 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 TYR G 486
LYS G 485
LYS G 227
 None
 1.32A 5dbyA-5te4G:
undetectable		 5dbyA-5te4G:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 3 TYR B 214
LYS B 176
LYS B 170
 None
 1.23A 5dbyA-5thzB:
undetectable		 5dbyA-5thzB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 3 TYR A 147
LYS A 160
LYS A 156
 None
 0.83A 5dbyA-5uanA:
undetectable		 5dbyA-5uanA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 TYR G 486
LYS G 485
LYS G 227
 None
 1.34A 5dbyA-5um8G:
undetectable		 5dbyA-5um8G:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urp TOXIN 2A

(Paenibacillus
larvae) 		no annotation 3 TYR A 156
LYS A  16
LYS A  12
 None
 0.91A 5dbyA-5urpA:
undetectable		 5dbyA-5urpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x42 DOTN

(Legionella
pneumophila) 		no annotation 3 TYR A  62
LYS A 199
LYS A 203
 None
 0.97A 5dbyA-5x42A:
1.5		 5dbyA-5x42A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		3 TYR A 521
LYS A 546
LYS A 684
 None
 1.16A 5dbyA-5xblA:
undetectable		 5dbyA-5xblA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES24

(Toxoplasma
gondii) 		PF01282
(Ribosomal_S24e) 		3 TYR Y 111
LYS Y 115
LYS Y 112
 G  2 457 ( 4.4A)
G  2  57 ( 2.7A)
G  2 458 ( 2.6A)
 1.33A 5dbyA-5xxuY:
undetectable		 5dbyA-5xxuY:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b85 TMHC4_R

(synthetic
construct) 		no annotation 3 TYR J 205
LYS J 190
LYS J 186
 None
 0.86A 5dbyA-6b85J:
undetectable		 5dbyA-6b85J:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 3 TYR I 450
LYS I 142
LYS I 139
 None
 0.81A 5dbyA-6bnpI:
undetectable		 5dbyA-6bnpI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0f RIBOSOME PRODUCTION
FACTOR 1

(Saccharomyces
cerevisiae) 		no annotation 3 TYR I 172
LYS I 174
LYS I 268
 None
 1.17A 5dbyA-6c0fI:
2.6		 5dbyA-6c0fI:
undetectable