SIMILAR PATTERNS OF AMINO ACIDS FOR 5D4U_B_SAMB301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ako EXONUCLEASE III

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		5 GLY A 150
LEU A  32
ILE A 148
LEU A 232
GLY A  64
 None
 1.10A 5d4uB-1akoA:
undetectable		 5d4uB-1akoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 138
ILE A 121
LEU A 122
THR A 115
GLY A  56
 None
 0.99A 5d4uB-1cg2A:
undetectable		 5d4uB-1cg2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		5 GLY A 443
TYR A 520
GLY A 502
GLY A 439
PHE A 539
 None
 1.01A 5d4uB-1d0nA:
undetectable		 5d4uB-1d0nA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5i DEACETOXYCEPHALOSPOR
IN C SYNTHASE

(Streptomyces
clavuligerus) 		PF03171
(2OG-FeII_Oxy) 		5 GLY A 227
LEU A 232
LEU A 191
GLY A 235
PHE A 152
 None
 1.08A 5d4uB-1e5iA:
undetectable		 5d4uB-1e5iA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 LEU A   3
HIS A  67
LEU A 104
GLY A  73
GLY A 206
 None
 1.10A 5d4uB-1ee8A:
undetectable		 5d4uB-1ee8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		5 GLY A 226
ILE A 265
LEU A 255
GLY A 289
GLY A 404
 None
None
None
GOL  A1449 (-3.9A)
None
 1.06A 5d4uB-1h4pA:
undetectable		 5d4uB-1h4pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu9 ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		5 GLY A 193
ILE A 211
LEU A 210
GLY A 120
GLY A 131
 None
 1.07A 5d4uB-1iu9A:
undetectable		 5d4uB-1iu9A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j85 YIBK

(Haemophilus
influenzae) 		PF00588
(SpoU_methylase) 		5 TYR A  96
ILE A 110
LEU A 111
GLY A 100
PHE A  66
 None
 1.07A 5d4uB-1j85A:
undetectable		 5d4uB-1j85A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Leishmania
mexicana) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 ILE A 241
MET A 319
LEU A 238
THR A 245
GLY A 202
 None
 1.11A 5d4uB-1m66A:
6.4		 5d4uB-1m66A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		5 GLY A 147
ILE A  98
HIS A  69
LEU A 112
GLY A 189
 None
None
ZN  A 802 ( 3.0A)
None
None
 1.11A 5d4uB-1m7jA:
undetectable		 5d4uB-1m7jA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		5 GLY A 197
HIS A 274
LEU A 271
GLY A 101
PHE A  97
 None
 1.09A 5d4uB-1px8A:
undetectable		 5d4uB-1px8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		5 GLY A  74
LEU A 241
ILE A  52
THR A  77
GLY A  67
 NAP  A3075 ( 4.7A)
None
None
None
None
 1.09A 5d4uB-1suwA:
undetectable		 5d4uB-1suwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvp CELLULASE

(Pseudoalteromonas
haloplanktis) 		PF00150
(Cellulase) 		5 GLY A 224
HIS A 253
THR A 225
GLY A 201
PHE A 246
 None
 1.11A 5d4uB-1tvpA:
undetectable		 5d4uB-1tvpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 104
ILE A  87
THR A 135
GLY A  46
GLY A 176
 None
None
GTP  A 500 (-3.6A)
GTP  A 500 (-2.7A)
None
 1.11A 5d4uB-1w5eA:
3.8		 5d4uB-1w5eA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1e STILBENE SYNTHASE

(Arachis
hypogaea) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 256
HIS A 161
THR A 264
GLY A 262
GLY A 211
 None
 1.01A 5d4uB-1z1eA:
undetectable		 5d4uB-1z1eA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		5 ILE A 198
LEU A 196
THR A 236
GLY A 168
GLY A 231
 None
 1.08A 5d4uB-1z9dA:
undetectable		 5d4uB-1z9dA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 336
ILE A   9
LEU A 358
GLY A  11
GLY A 192
 FAD  A1002 (-3.1A)
FAD  A1002 (-4.8A)
None
None
FAD  A1002 ( 4.6A)
 1.08A 5d4uB-2e5vA:
2.6		 5d4uB-2e5vA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa;
Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 GLY B 328
ILE A 145
HIS A  31
GLY B 298
PHE A  30
 None
 1.09A 5d4uB-2fpgB:
2.4		 5d4uB-2fpgB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0y PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece sp.
ATCC 51142) 		PF00805
(Pentapeptide) 		5 LEU A  59
THR A 100
GLY A 123
GLY A  61
PHE A 104
 None
 1.00A 5d4uB-2g0yA:
undetectable		 5d4uB-2g0yA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		5 GLY A 387
ILE A 401
LEU A 405
GLY A  11
GLY A 175
 FAD  A 501 (-3.2A)
FAD  A 501 (-3.6A)
None
FAD  A 501 (-3.4A)
None
 0.99A 5d4uB-2i0zA:
2.7		 5d4uB-2i0zA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i53 CYCLIN K

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		5 GLY A  96
TYR A  77
LEU A 102
HIS A  79
GLY A 104
 None
 0.95A 5d4uB-2i53A:
undetectable		 5d4uB-2i53A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icg LIN2918 PROTEIN

(Listeria
innocua) 		PF14568
(SUKH_6) 		5 GLY A  65
LEU A  56
ILE A  97
LEU A  38
PHE A 143
 None
 1.07A 5d4uB-2icgA:
undetectable		 5d4uB-2icgA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis) 		PF01979
(Amidohydro_1) 		5 GLY A  82
TYR A 369
ILE A 360
THR A 332
GLY A 365
 None
 1.12A 5d4uB-2icsA:
undetectable		 5d4uB-2icsA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 GLY A  30
LEU A 307
LEU A  67
GLY A  60
GLY A 304
 GLY  A  30 ( 0.0A)
LEU  A 307 ( 0.6A)
LEU  A  67 ( 0.6A)
GLY  A  60 ( 0.0A)
GLY  A 304 ( 0.0A)
 0.87A 5d4uB-2nvvA:
2.6		 5d4uB-2nvvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		5 GLY A  33
LEU A  42
GLY A  15
GLY A 113
PHE A   6
 SO4  A 254 (-3.4A)
None
None
None
None
 1.03A 5d4uB-2nwqA:
6.3		 5d4uB-2nwqA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY 1  74
ILE 1  57
THR 1 105
GLY 1  16
GLY 1 146
 None
None
GDP  1 339 (-4.3A)
GDP  1 339 (-3.5A)
None
 1.05A 5d4uB-2r6r1:
3.7		 5d4uB-2r6r1:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
CIT  A 401 (-3.6A)
CIT  A 401 (-3.5A)
None
 0.89A 5d4uB-2vxyA:
undetectable		 5d4uB-2vxyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00854
(PTR2) 		5 GLY A  66
LEU A 116
LEU A 448
GLY A 125
GLY A  98
 None
 1.12A 5d4uB-2xutA:
undetectable		 5d4uB-2xutA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		5 GLY A 494
TYR A 492
LEU A 488
GLY A 615
PHE A 237
 None
 1.05A 5d4uB-2xy9A:
undetectable		 5d4uB-2xy9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 GLY A 104
LEU A 203
THR A 285
GLY A 201
PHE A 289
 None
 1.04A 5d4uB-2yzmA:
undetectable		 5d4uB-2yzmA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		5 GLY A 153
TYR A 151
ILE A 176
LEU A 172
GLY A 179
 None
 1.10A 5d4uB-2zuyA:
undetectable		 5d4uB-2zuyA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 174
LEU A 179
ILE A  41
HIS A  39
THR A 173
 None
None
None
None
TLA  A 502 (-3.6A)
 1.02A 5d4uB-3d46A:
undetectable		 5d4uB-3d46A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		6 ILE A 157
LEU A  98
THR A 166
GLY A 162
GLY A 301
PHE A 170
 None
 1.40A 5d4uB-3e49A:
undetectable		 5d4uB-3e49A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 164
LEU A 169
ILE A  32
HIS A  30
THR A 163
 None
None
None
None
TLA  A 501 ( 3.8A)
 1.06A 5d4uB-3ekgA:
undetectable		 5d4uB-3ekgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4k PUTATIVE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF13649
(Methyltransf_25) 		5 GLY A 254
TYR A 252
LEU A 140
GLY A 187
PHE A 129
 None
 1.08A 5d4uB-3f4kA:
5.3		 5d4uB-3f4kA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 301
THR A 352
GLY A 284
GLY A 349
PHE A 135
 None
 1.04A 5d4uB-3g25A:
undetectable		 5d4uB-3g25A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)

(Archaeoglobus
fulgidus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A 386
LEU A 365
GLY A 334
GLY A 187
PHE A 392
 None
 1.12A 5d4uB-3g7sA:
3.4		 5d4uB-3g7sA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grf ORNITHINE
CARBAMOYLTRANSFERASE

(Giardia
intestinalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A 219
ILE A 211
HIS A 215
GLY A 180
GLY A 157
 None
 0.72A 5d4uB-3grfA:
5.1		 5d4uB-3grfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1s SUPEROXIDE DISMUTASE

(Francisella
tularensis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 LEU A 145
ILE A  64
HIS A  48
LEU A  42
GLY A  62
 None
 1.09A 5d4uB-3h1sA:
undetectable		 5d4uB-3h1sA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h20 REPLICATION PROTEIN
B

(Plasmid RSF1010) 		PF16793
(RepB_primase) 		5 GLY A  72
ILE A 123
LEU A 119
GLY A 179
GLY A 173
 None
 1.05A 5d4uB-3h20A:
undetectable		 5d4uB-3h20A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h25 REPLICATION PROTEIN
B

(Plasmid RSF1010) 		PF16793
(RepB_primase) 		5 GLY A  72
ILE A 123
LEU A 119
GLY A 179
GLY A 173
 None
 1.06A 5d4uB-3h25A:
undetectable		 5d4uB-3h25A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2n WD REPEAT-CONTAINING
PROTEIN 92

(Homo sapiens) 		PF00400
(WD40) 		5 TYR A 105
LEU A  97
THR A  85
GLY A  71
GLY A 109
 None
 1.09A 5d4uB-3i2nA:
undetectable		 5d4uB-3i2nA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ico 6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacterium
tuberculosis) 		PF01182
(Glucosamine_iso) 		5 GLY A 229
LEU A 234
ILE A 191
HIS A 143
GLY A 226
 None
 1.05A 5d4uB-3icoA:
4.4		 5d4uB-3icoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 GLY X 353
LEU X 618
THR X 377
GLY X 395
GLY X 349
 None
 1.06A 5d4uB-3kvnX:
undetectable		 5d4uB-3kvnX:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
marinum) 		PF00797
(Acetyltransf_2) 		6 GLY A 129
TYR A  69
LEU A 176
GLY A 132
GLY A  67
PHE A 204
 None
HLZ  A 300 (-4.1A)
None
None
None
HLZ  A 300 (-4.4A)
 1.34A 5d4uB-3ltwA:
undetectable		 5d4uB-3ltwA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		5 LEU K 190
ILE K 298
THR K 249
GLY K 300
GLY K 134
 None
 1.08A 5d4uB-3mvdK:
undetectable		 5d4uB-3mvdK:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 ILE A 255
LEU A 252
GLY A 223
GLY A  55
PHE A 265
 None
None
None
MCL  A 174 ( 3.2A)
None
 1.12A 5d4uB-3n2xA:
undetectable		 5d4uB-3n2xA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		5 GLY A 322
LEU A  85
ILE A 319
GLY A 272
GLY A 111
 PLP  A 701 (-3.3A)
None
None
PLP  A 701 ( 4.2A)
None
 1.09A 5d4uB-3nzpA:
undetectable		 5d4uB-3nzpA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 GLY A  74
LEU A  34
LEU A 283
GLY A  63
GLY A  31
 None
 1.12A 5d4uB-3oeeA:
undetectable		 5d4uB-3oeeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqv RCL1 PROTEIN

(Kluyveromyces
lactis) 		PF01137
(RTC)
PF05189
(RTC_insert) 		5 GLY A 302
TYR A 298
ILE A 351
THR A 178
GLY A 144
 None
 0.99A 5d4uB-3pqvA:
undetectable		 5d4uB-3pqvA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli) 		PF00860
(Xan_ur_permease) 		5 TYR A  68
ILE A  65
LEU A 257
THR A 303
GLY A  63
 None
 1.08A 5d4uB-3qe7A:
undetectable		 5d4uB-3qe7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		5 LEU A 178
TRP A 236
ILE A 184
LEU A 185
GLY A   9
 None
None
None
None
GLU  A 258 ( 4.0A)
 1.13A 5d4uB-3t7bA:
undetectable		 5d4uB-3t7bA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uow GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 GLY A 204
LEU A  55
ILE A 192
LEU A 183
GLY A  57
 None
 1.10A 5d4uB-3uowA:
2.3		 5d4uB-3uowA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
GDP  A 400 (-3.3A)
GDP  A 400 (-3.5A)
None
 0.97A 5d4uB-3wgkA:
3.6		 5d4uB-3wgkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		5 GLY A  14
LEU A 291
LEU A  20
GLY A  47
GLY A 289
 FAD  A 601 (-3.2A)
None
None
FAD  A 601 (-3.4A)
None
 1.12A 5d4uB-3x0vA:
2.7		 5d4uB-3x0vA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		5 GLY A 361
ILE A 375
LEU A 379
GLY A  12
GLY A 174
 FAD  A1392 (-3.2A)
FAD  A1392 (-4.2A)
None
FAD  A1392 (-3.4A)
None
 1.06A 5d4uB-4cnkA:
undetectable		 5d4uB-4cnkA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2p CYTOCHROME P450
107B1 (P450CVIIB1)

(Streptomyces
himastatinicus) 		PF00067
(p450) 		5 GLY A 356
LEU A 351
LEU A 272
GLY A 237
PHE A 339
 None
None
None
HEM  A 401 (-3.4A)
None
 1.08A 5d4uB-4e2pA:
undetectable		 5d4uB-4e2pA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdz TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		5 TYR A  96
ILE A 110
LEU A 111
GLY A 100
PHE A  66
 None
 1.02A 5d4uB-4kdzA:
undetectable		 5d4uB-4kdzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 5 GLY A 727
LEU A 449
THR A 725
GLY A 724
GLY A  60
 None
None
None
None
EDO  A 805 (-3.7A)
 0.97A 5d4uB-4lgnA:
undetectable		 5d4uB-4lgnA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 GLY A 229
ILE A 245
GLY A 212
GLY A 202
PHE A 250
 None
 1.03A 5d4uB-4lrsA:
undetectable		 5d4uB-4lrsA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 GLY A1294
TYR A1312
LEU A1071
THR A1310
GLY A1093
 ATP  A1402 ( 3.7A)
ATP  A1402 (-4.9A)
None
ATP  A1402 (-4.7A)
None
 1.11A 5d4uB-4n1aA:
undetectable		 5d4uB-4n1aA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4g ZINC FINGER MYND
DOMAIN-CONTAINING
PROTEIN 11

(Mus musculus) 		PF00439
(Bromodomain)
PF00855
(PWWP) 		5 LEU A 244
ILE A 229
HIS A 225
LEU A 191
GLY A 232
 None
 1.12A 5d4uB-4n4gA:
undetectable		 5d4uB-4n4gA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE

(Campylobacter
jejuni) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A  77
ILE A 199
HIS A 201
GLY A  74
GLY A  12
 None
 0.87A 5d4uB-4oc9A:
4.0		 5d4uB-4oc9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8f VACUOLAR
AMINOPEPTIDASE 1

(Saccharomyces
cerevisiae) 		PF02127
(Peptidase_M18) 		5 GLY A 304
LEU A 291
ILE A 297
GLY A 410
GLY A  86
 None
 1.12A 5d4uB-4r8fA:
undetectable		 5d4uB-4r8fA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE

(Mycobacterium
tuberculosis) 		no annotation 5 GLY B 362
TYR B 250
THR B 244
GLY B  14
PHE B 226
 None
None
FAD  B 401 (-4.6A)
FAD  B 401 (-3.3A)
FAD  B 401 (-4.4A)
 1.06A 5d4uB-4rphB:
undetectable		 5d4uB-4rphB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4win GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase) 		5 GLY A 204
LEU A  55
ILE A 192
LEU A 183
GLY A  57
 None
None
None
None
NO3  A1002 (-3.9A)
 1.10A 5d4uB-4winA:
undetectable		 5d4uB-4winA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgk UDP-GALACTOPYRANOSE
MUTASE

(Corynebacterium
diphtheriae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 GLY A 360
TYR A 246
THR A 240
GLY A  10
PHE A 222
 None
None
FDA  A 403 ( 4.6A)
FDA  A 403 (-3.1A)
FDA  A 403 (-4.6A)
 0.98A 5d4uB-4xgkA:
undetectable		 5d4uB-4xgkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybr NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		5 GLY A  11
HIS A  17
THR A 106
GLY A 107
GLY A   7
 NAP  A 301 (-3.4A)
NAP  A 301 (-4.0A)
NAP  A 301 (-3.4A)
NAP  A 301 (-3.1A)
None
 1.07A 5d4uB-4ybrA:
undetectable		 5d4uB-4ybrA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		5 GLY A 207
TYR A 101
THR A  82
GLY A 104
PHE A  25
 None
None
GSH  A 401 (-4.3A)
None
None
 1.12A 5d4uB-4z9nA:
undetectable		 5d4uB-4z9nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo3 ACYLHOMOSERINE
LACTONASE

(Chryseobacterium
sp. StRB126) 		PF00753
(Lactamase_B) 		5 GLY A  58
LEU A  55
ILE A  60
HIS A 305
THR A 121
 None
None
C6L  A 403 ( 4.7A)
ZN  A 402 ( 3.3A)
None
 1.08A 5d4uB-4zo3A:
undetectable		 5d4uB-4zo3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5x AQUAPORIN-5

(Homo sapiens) 		PF00230
(MIP) 		5 GLY A 166
LEU A  56
HIS A 173
LEU A 171
GLY A  66
 None
 1.01A 5d4uB-5c5xA:
undetectable		 5d4uB-5c5xA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23

(Homo sapiens) 		PF03097
(BRO1) 		5 GLY A  73
LEU A  68
ILE A 356
THR A 352
GLY A 353
 None
 0.93A 5d4uB-5crvA:
undetectable		 5d4uB-5crvA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d5t UNCHARACTERIZED
PROTEIN MJ0489

(Methanocaldococcus
jannaschii) 		PF06690
(DUF1188) 		6 GLY A  54
ILE A  78
LEU A  97
THR A 118
GLY A 122
GLY A 184
 None
 0.60A 5d4uB-5d5tA:
35.7		 5d4uB-5d5tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqd UDP-GALACTOPYRANOSE
MUTASE

(Mycolicibacterium
smegmatis) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 GLY A 371
TYR A 259
THR A 253
GLY A  23
PHE A 235
 None
None
FAD  A 501 (-4.5A)
FAD  A 501 (-3.1A)
FAD  A 501 (-4.6A)
 0.98A 5d4uB-5eqdA:
2.5		 5d4uB-5eqdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Hirschia
baltica) 		PF00160
(Pro_isomerase) 		5 GLY A  60
ILE A  77
LEU A  81
GLY A  56
PHE A 169
 None
 0.80A 5d4uB-5ex2A:
undetectable		 5d4uB-5ex2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 5 GLY A 282
ILE A 225
LEU A 266
GLY A 202
GLY A 158
 None
 1.09A 5d4uB-5f75A:
undetectable		 5d4uB-5f75A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 5 GLY A 756
LEU A 481
THR A 754
GLY A 753
GLY A  92
 None
 0.99A 5d4uB-5fkrA:
undetectable		 5d4uB-5fkrA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1

(Mus musculus) 		PF01344
(Kelch_1) 		5 GLY A 605
LEU A 557
LEU A 358
GLY A 379
GLY A 509
 None
None
None
None
L6I  A1615 (-3.0A)
 1.10A 5d4uB-5fnuA:
undetectable		 5d4uB-5fnuA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY C  33
LEU A 137
GLY A 164
GLY C 239
PHE A 156
 None
 1.09A 5d4uB-5g5gC:
undetectable		 5d4uB-5g5gC:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome) 		PF00232
(Glyco_hydro_1) 		5 GLY A 222
TRP A 166
LEU A 258
GLY A 207
GLY A 217
 None
 1.07A 5d4uB-5gnxA:
undetectable		 5d4uB-5gnxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE

(Francisella
tularensis) 		PF01761
(DHQ_synthase) 		5 GLY A 112
ILE A 145
LEU A  80
GLY A 155
GLY A 140
 None
 0.99A 5d4uB-5hvnA:
undetectable		 5d4uB-5hvnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME

(Brucella
melitensis) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 244
TYR A 242
ILE A 250
GLY A 252
GLY A 221
 None
 0.98A 5d4uB-5ijgA:
2.4		 5d4uB-5ijgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 GLY A 261
HIS A 299
LEU A 309
GLY A 429
GLY A 800
 None
 1.11A 5d4uB-5ja1A:
2.6		 5d4uB-5ja1A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kku POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		5 TYR A  43
ILE A  91
LEU A  76
THR A  37
GLY A  35
 None
 1.12A 5d4uB-5kkuA:
undetectable		 5d4uB-5kkuA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kte DIVALENT METAL
CATION TRANSPORTER
MNTH

(Deinococcus
radiodurans) 		PF01566
(Nramp) 		5 GLY A 223
LEU A 374
ILE A 423
GLY A 216
GLY A 295
 None
 1.05A 5d4uB-5kteA:
undetectable		 5d4uB-5kteA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		5 GLY A 463
LEU A 342
LEU A 128
THR A 543
GLY A 338
 None
 1.11A 5d4uB-5mqmA:
undetectable		 5d4uB-5mqmA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 5 GLY A  38
ILE A 448
GLY A  70
GLY A 110
PHE A 466
 None
 1.02A 5d4uB-5muxA:
undetectable		 5d4uB-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE

(Galerina
marginata) 		no annotation 5 GLY A 498
ILE A 527
GLY A 495
GLY A 603
PHE A 550
 None
 1.01A 5d4uB-5n4cA:
undetectable		 5d4uB-5n4cA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 5 GLY A 483
ILE A 512
GLY A 480
GLY A 587
PHE A 535
 None
 1.08A 5d4uB-5o3wA:
undetectable		 5d4uB-5o3wA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o4m HCGC

(Methanococcus
maripaludis) 		PF06690
(DUF1188) 		9 GLY A  49
TYR A  51
LEU A  52
ILE A  73
LEU A  91
THR A 113
GLY A 117
GLY A 176
PHE A 213
 SAH  A 301 (-3.4A)
None
SAH  A 301 ( 4.3A)
SAH  A 301 (-3.9A)
SAH  A 301 ( 3.9A)
SAH  A 301 ( 4.1A)
SAH  A 301 (-3.4A)
9KH  A 302 ( 3.3A)
SAH  A 301 (-4.8A)
 0.42A 5d4uB-5o4mA:
35.8		 5d4uB-5o4mA:
51.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o4m HCGC

(Methanococcus
maripaludis) 		PF06690
(DUF1188) 		5 TYR A  51
LEU A  52
GLY A 116
GLY A 176
PHE A 213
 None
SAH  A 301 ( 4.3A)
None
9KH  A 302 ( 3.3A)
SAH  A 301 (-4.8A)
 0.95A 5d4uB-5o4mA:
35.8		 5d4uB-5o4mA:
51.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 GLY A 556
ILE A 595
LEU A 583
GLY A 586
GLY A 552
 None
None
None
EDO  A 904 (-3.5A)
None
 1.12A 5d4uB-5okoA:
undetectable		 5d4uB-5okoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A  58
ILE A 195
LEU A  64
GLY A  54
GLY A 187
 7SG  A 402 (-3.5A)
None
None
None
None
 1.07A 5d4uB-5u24A:
2.9		 5d4uB-5u24A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wue UNCHARACTERIZED
PROTEIN

(Sulfolobus
acidocaldarius) 		PF03458
(UPF0126) 		5 GLY A  50
LEU A  57
THR A 131
GLY A 110
GLY A  16
 None
 1.10A 5d4uB-5wueA:
undetectable		 5d4uB-5wueA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 5 GLY A 284
ILE A  46
GLY A  43
GLY A 191
PHE A  70
 None
None
FAD  A 501 ( 3.9A)
None
None
 1.10A 5d4uB-5xgvA:
undetectable		 5d4uB-5xgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
SMALL SUBUNIT
ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400;
Methylobacillus
sp. KY4400) 		no annotation
no annotation 		5 GLY C  49
LEU A  81
GLY A 109
GLY C 259
PHE A 101
 None
 1.12A 5d4uB-5y6qC:
undetectable		 5d4uB-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 5 LEU A 106
ILE A 279
MET A 391
THR A 249
GLY A 133
 None
None
None
C6M  A 401 ( 4.9A)
None
 1.07A 5d4uB-6b07A:
undetectable		 5d4uB-6b07A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cy1 SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Elizabethkingia
anophelis) 		no annotation 5 GLY A 276
ILE A 281
GLY A 242
GLY A  19
PHE A 304
 None
 1.10A 5d4uB-6cy1A:
undetectable		 5d4uB-6cy1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e2q -

(-) 		no annotation 6 GLY A 295
ILE A 289
LEU A 314
THR A 291
GLY A 371
PHE A 365
 None
 1.27A 5d4uB-6e2qA:
undetectable		 5d4uB-6e2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 5 GLY A  72
LEU A 122
GLY A 131
GLY A 104
PHE A  33
 78M  A 606 ( 3.9A)
78M  A 606 ( 4.3A)
None
None
None
 1.11A 5d4uB-6ei3A:
undetectable		 5d4uB-6ei3A:
17.70