SIMILAR PATTERNS OF AMINO ACIDS FOR 5D0Y_A_FOLA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL

(Escherichia
coli) 		PF00072
(Response_reg)
PF00196
(GerE) 		3 ARG A 151
LYS A 201
GLU A 205
 None
 0.77A 5d0yA-1a04A:
0.0		 5d0yA-1a04A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci0 PROTEIN (PNP
OXIDASE)

(Saccharomyces
cerevisiae) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 ARG A 117
LYS A  41
GLU A  45
 None
 0.53A 5d0yA-1ci0A:
0.0		 5d0yA-1ci0A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cz3 DIHYDROFOLATE
REDUCTASE

(Thermotoga
maritima) 		PF00186
(DHFR_1) 		3 ARG A 149
LYS A 160
GLU A 147
 None
 0.82A 5d0yA-1cz3A:
undetectable		 5d0yA-1cz3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		3 ARG A 556
LYS A 551
GLU A 555
 ATP  A 602 (-4.0A)
None
None
 0.80A 5d0yA-1gz4A:
0.0		 5d0yA-1gz4A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		3 ARG A  42
LYS A  88
GLU A  91
 None
 0.82A 5d0yA-1ij5A:
0.0		 5d0yA-1ij5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq6 (R)-SPECIFIC
ENOYL-COA HYDRATASE

(Aeromonas
caviae) 		PF01575
(MaoC_dehydratas) 		3 ARG A  12
LYS A  10
GLU A  96
 None
 0.68A 5d0yA-1iq6A:
undetectable		 5d0yA-1iq6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		3 ARG A 244
LYS A 238
GLU A 240
 None
 0.76A 5d0yA-1jeqA:
0.1		 5d0yA-1jeqA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onk GALACTOSE SPECIFIC
LECTIN I B CHAIN

(Viscum album) 		PF00652
(Ricin_B_lectin) 		3 ARG B  54
LYS B  53
GLU B   9
 None
 0.72A 5d0yA-1onkB:
undetectable		 5d0yA-1onkB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		3 ARG A 123
LYS A 117
GLU A 121
 GOL  A1902 (-4.1A)
None
GOL  A1902 (-3.3A)
 0.74A 5d0yA-1uarA:
undetectable		 5d0yA-1uarA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		3 ARG A 152
LYS A 125
GLU A 104
 None
 0.83A 5d0yA-1v2dA:
0.0		 5d0yA-1v2dA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 ARG A  58
LYS A 248
GLU A 252
 None
 0.77A 5d0yA-1vdkA:
1.7		 5d0yA-1vdkA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		3 ARG A 127
LYS A 120
GLU A 123
 None
 0.69A 5d0yA-1wy0A:
2.7		 5d0yA-1wy0A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5l EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF00041
(fn3) 		3 ARG A  86
LYS A  62
GLU A  45
 None
 0.75A 5d0yA-1x5lA:
undetectable		 5d0yA-1x5lA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ARG A 288
LYS A 132
GLU A 118
 None
 0.72A 5d0yA-1xdiA:
undetectable		 5d0yA-1xdiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE

(Enterococcus
faecalis) 		PF01515
(PTA_PTB) 		3 ARG A 267
LYS A  20
GLU A  24
 None
 0.78A 5d0yA-1ycoA:
undetectable		 5d0yA-1ycoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		3 ARG A 136
LYS A   7
GLU A  11
 None
 0.82A 5d0yA-1yggA:
undetectable		 5d0yA-1yggA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		3 ARG A  94
LYS A 117
GLU A  67
 None
 0.75A 5d0yA-1zzgA:
undetectable		 5d0yA-1zzgA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a90 DELTEX PROTEIN

(Drosophila
melanogaster) 		PF02825
(WWE) 		3 ARG A 200
LYS A 132
GLU A 134
 None
 0.73A 5d0yA-2a90A:
undetectable		 5d0yA-2a90A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind)
PF08548
(Peptidase_M10_C) 		3 ARG A  62
LYS A 114
GLU A 126
 None
 0.75A 5d0yA-2agmA:
undetectable		 5d0yA-2agmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		3 ARG A  12
LYS A  60
GLU A  64
 None
 0.81A 5d0yA-2cyaA:
undetectable		 5d0yA-2cyaA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		3 ARG A 356
LYS A 349
GLU A 352
 None
 0.74A 5d0yA-2dhtA:
undetectable		 5d0yA-2dhtA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 ARG A 175
LYS A 153
GLU A 157
 None
 0.79A 5d0yA-2e1bA:
undetectable		 5d0yA-2e1bA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF14681
(UPRTase) 		3 ARG A  27
LYS A  26
GLU A  30
 None
 0.76A 5d0yA-2ehjA:
undetectable		 5d0yA-2ehjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		3 ARG A 181
LYS A 175
GLU A 179
 None
 0.79A 5d0yA-2ffhA:
3.0		 5d0yA-2ffhA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 ARG A  58
LYS A  51
GLU A  54
 None
 0.79A 5d0yA-2i4nA:
undetectable		 5d0yA-2i4nA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jya UNCHARACTERIZED
PROTEIN ATU1810

(Agrobacterium
fabrum) 		PF04800
(ETC_C1_NDUFA4) 		3 ARG A   7
LYS A  78
GLU A  79
 None
 0.72A 5d0yA-2jyaA:
undetectable		 5d0yA-2jyaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k6b PROGRAMMED CELL
DEATH PROTEIN 5

(Homo sapiens) 		PF01984
(dsDNA_bind) 		3 ARG A  40
LYS A  33
GLU A  36
 None
 0.78A 5d0yA-2k6bA:
undetectable		 5d0yA-2k6bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Bacteroides sp.
4_3_47FAA) 		PF00578
(AhpC-TSA) 		3 ARG A  45
LYS A  79
GLU A  83
 None
 0.82A 5d0yA-2lrnA:
undetectable		 5d0yA-2lrnA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2muy ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Escherichia
coli) 		PF06480
(FtsH_ext) 		3 ARG A  47
LYS A  87
GLU A  48
 None
 0.69A 5d0yA-2muyA:
undetectable		 5d0yA-2muyA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 ARG A 255
LYS A 291
GLU A 273
 None
 0.63A 5d0yA-2oi6A:
undetectable		 5d0yA-2oi6A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppq HOMOSERINE KINASE

(Agrobacterium
fabrum) 		PF01636
(APH) 		3 ARG A 119
LYS A 245
GLU A 249
 None
 0.80A 5d0yA-2ppqA:
undetectable		 5d0yA-2ppqA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		3 ARG A 221
LYS A 218
GLU A 219
 None
 0.74A 5d0yA-2qmiA:
undetectable		 5d0yA-2qmiA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv8 GENERAL SECRETION
PATHWAY PROTEIN H

(Vibrio cholerae) 		PF12019
(GspH) 		3 ARG A  60
LYS A  81
GLU A 136
 None
 0.80A 5d0yA-2qv8A:
undetectable		 5d0yA-2qv8A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vad RED FLUORESCENT
PROTEIN

(Discosoma sp.) 		PF01353
(GFP) 		3 ARG A  17
LYS A  50
GLU A  28
 None
 0.70A 5d0yA-2vadA:
undetectable		 5d0yA-2vadA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnx GLYCOSIDE HYDROLASE,
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		3 ARG A  51
LYS A  49
GLU A  95
 None
 0.78A 5d0yA-2wnxA:
undetectable		 5d0yA-2wnxA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 ARG A 182
LYS A 175
GLU A 178
 None
 0.70A 5d0yA-2wrtA:
undetectable		 5d0yA-2wrtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE

(Streptococcus
pneumoniae) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		3 ARG A 299
LYS A 308
GLU A 276
 None
 0.78A 5d0yA-2wwdA:
undetectable		 5d0yA-2wwdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfa ACTIN
DEPOLYMERIZATION
FACTOR 2

(Plasmodium
berghei) 		PF00241
(Cofilin_ADF) 		3 ARG A  68
LYS A  63
GLU A  66
 None
 0.76A 5d0yA-2xfaA:
undetectable		 5d0yA-2xfaA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		3 ARG A 193
LYS A 291
GLU A 293
 None
 0.60A 5d0yA-2z6iA:
undetectable		 5d0yA-2z6iA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 ARG B 441
LYS B 415
GLU B 414
 None
 0.73A 5d0yA-2z7xB:
undetectable		 5d0yA-2z7xB:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 ARG A1139
LYS A1127
GLU A1129
 None
 0.66A 5d0yA-2zxqA:
undetectable		 5d0yA-2zxqA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF03480
(DctP) 		3 ARG A  33
LYS A  60
GLU A  68
 None
 0.76A 5d0yA-2zzwA:
undetectable		 5d0yA-2zzwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db1 STS-2 PROTEIN

(Mus musculus) 		PF00300
(His_Phos_1) 		3 ARG A 425
LYS A 454
GLU A 458
 None
 0.66A 5d0yA-3db1A:
undetectable		 5d0yA-3db1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN

(Sulfolobus
solfataricus) 		PF00571
(CBS) 		3 ARG A 252
LYS A 140
GLU A 223
 None
 0.79A 5d0yA-3ddjA:
undetectable		 5d0yA-3ddjA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgt ENDO-1,3-BETA-GLUCAN
ASE

(Streptomyces
sioyaensis) 		PF00722
(Glyco_hydro_16) 		3 ARG A 101
LYS A  99
GLU A 196
 None
 0.83A 5d0yA-3dgtA:
undetectable		 5d0yA-3dgtA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlv SIGNAL RECOGNITION
PARTICLE 19 KDA
PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 ARG B  98
LYS B  91
GLU B  94
 None
 0.70A 5d0yA-3dlvB:
undetectable		 5d0yA-3dlvB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		3 ARG A 125
LYS A 186
GLU A 190
 None
 0.74A 5d0yA-3eu8A:
undetectable		 5d0yA-3eu8A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		3 ARG A 406
LYS A 451
GLU A 455
 None
 0.80A 5d0yA-3gitA:
undetectable		 5d0yA-3gitA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc7 GENE 12 PROTEIN

(Mycobacterium
virus D29) 		PF01083
(Cutinase) 		3 ARG A 159
LYS A 112
GLU A 157
 None
 0.77A 5d0yA-3hc7A:
undetectable		 5d0yA-3hc7A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw 50S RIBOSOMAL
PROTEIN L7AE

(Pyrococcus
furiosus) 		PF01248
(Ribosomal_L7Ae) 		3 ARG C  34
LYS C  35
GLU C  39
 G  D  24 ( 3.1A)
A  D  25 ( 2.7A)
G  D  31 ( 3.7A)
 0.76A 5d0yA-3hjwC:
undetectable		 5d0yA-3hjwC:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkf IGH PROTEIN

(Mus musculus) 		PF07654
(C1-set) 		3 ARG A 325
LYS A 323
GLU A 336
 None
 0.73A 5d0yA-3hkfA:
undetectable		 5d0yA-3hkfA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		3 ARG M 406
LYS M 451
GLU M 455
 None
 0.81A 5d0yA-3i04M:
undetectable		 5d0yA-3i04M:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		3 ARG A 286
LYS A 253
GLU A 252
 None
 0.77A 5d0yA-3jurA:
undetectable		 5d0yA-3jurA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmd CGMP DEPENDENT
PROTEIN KINASE

(Homo sapiens) 		no annotation 3 ARG A  21
LYS A  14
GLU A  17
 None
 0.59A 5d0yA-3nmdA:
undetectable		 5d0yA-3nmdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrk LIC12922

(Leptospira
interrogans) 		PF13145
(Rotamase_2)
PF13624
(SurA_N_3) 		3 ARG A 200
LYS A 297
GLU A 299
 None
 0.67A 5d0yA-3nrkA:
undetectable		 5d0yA-3nrkA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		3 ARG A 133
LYS A 161
GLU A 123
 None
 0.75A 5d0yA-3ooiA:
undetectable		 5d0yA-3ooiA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		3 ARG X 124
LYS X 117
GLU X 120
 None
 0.60A 5d0yA-3pb9X:
undetectable		 5d0yA-3pb9X:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sw0 COMPLEMENT FACTOR H

(Homo sapiens) 		PF00084
(Sushi) 		3 ARG X1149
LYS X1148
GLU X1135
 None
 0.79A 5d0yA-3sw0X:
undetectable		 5d0yA-3sw0X:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A

(Arabidopsis
thaliana) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		3 ARG A 167
LYS A 160
GLU A 163
 None
 0.63A 5d0yA-3t34A:
undetectable		 5d0yA-3t34A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 ARG A 464
LYS A 429
GLU A 433
 None
 0.69A 5d0yA-3zzuA:
undetectable		 5d0yA-3zzuA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC

(Leishmania
major) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 ARG A 111
LYS A 115
GLU A  82
 None
 0.83A 5d0yA-4a26A:
undetectable		 5d0yA-4a26A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		3 ARG A 582
LYS A 575
GLU A 578
 None
 0.58A 5d0yA-4az7A:
undetectable		 5d0yA-4az7A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bof ARGININE DEIMINASE

(Streptococcus
pyogenes) 		PF02274
(Amidinotransf) 		3 ARG A 299
LYS A 316
GLU A 314
 None
 0.78A 5d0yA-4bofA:
undetectable		 5d0yA-4bofA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g88 OUTER MEMBRANE
PROTEIN OMP38

(Acinetobacter
baumannii) 		PF00691
(OmpA) 		3 ARG A 339
LYS A 255
GLU A 258
 None
 0.64A 5d0yA-4g88A:
undetectable		 5d0yA-4g88A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgh CULLIN-5

(Homo sapiens) 		PF00888
(Cullin) 		3 ARG D 244
LYS D 237
GLU D 240
 None
 0.77A 5d0yA-4jghD:
undetectable		 5d0yA-4jghD:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		3 ARG A 133
LYS A 130
GLU A 124
 None
 0.67A 5d0yA-4n7tA:
undetectable		 5d0yA-4n7tA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9f CULLIN-5

(Homo sapiens) 		no annotation 3 ARG U 244
LYS U 237
GLU U 240
 None
 0.78A 5d0yA-4n9fU:
undetectable		 5d0yA-4n9fU:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqi SH3
DOMAIN-CONTAINING
PROTEIN

(Dictyostelium
discoideum) 		PF08397
(IMD) 		3 ARG A  86
LYS A 196
GLU A 199
 None
 0.66A 5d0yA-4nqiA:
3.5		 5d0yA-4nqiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		3 ARG A 479
LYS A 477
GLU A 486
 None
 0.65A 5d0yA-4phcA:
0.4		 5d0yA-4phcA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		3 ARG A  52
LYS A  56
GLU A  21
 None
 0.75A 5d0yA-4q8lA:
undetectable		 5d0yA-4q8lA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rj9 C2 DOMAIN-CONTAINING
PROTEIN-LIKE

(Oryza sativa) 		PF00168
(C2) 		3 ARG A  12
LYS A  10
GLU A  56
 None
 0.75A 5d0yA-4rj9A:
undetectable		 5d0yA-4rj9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2

(Homo sapiens) 		PF06470
(SMC_hinge) 		3 ARG A 566
LYS A 561
GLU A 565
 None
 0.73A 5d0yA-4u4pA:
undetectable		 5d0yA-4u4pA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8s RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00161
(RIP) 		3 ARG A  22
LYS A  15
GLU A 168
 None
 0.65A 5d0yA-4z8sA:
undetectable		 5d0yA-4z8sA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgs PUTATIVE D-LACTATE
DEHYDROGENASE

(Chlamydomonas
reinhardtii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ARG A 127
LYS A 369
GLU A 367
 None
 0.80A 5d0yA-4zgsA:
undetectable		 5d0yA-4zgsA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		3 ARG A  42
LYS A 105
GLU A 109
 None
 0.70A 5d0yA-4zwnA:
undetectable		 5d0yA-4zwnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		3 ARG C 789
LYS C 782
GLU C 785
 None
 0.83A 5d0yA-5a5tC:
undetectable		 5d0yA-5a5tC:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5auo ATPASE INVOLVED IN
CHROMOSOME
PARTITIONING,
PARA/MIND FAMILY,
MRP HOMOLOG

(Thermococcus
kodakarensis) 		PF10609
(ParA) 		3 ARG B 247
LYS B 240
GLU B 243
 None
 0.73A 5d0yA-5auoB:
undetectable		 5d0yA-5auoB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4s CONTACTIN-4

(Mus musculus) 		PF00041
(fn3) 		3 ARG A 854
LYS A 852
GLU A 837
 None
 0.78A 5d0yA-5e4sA:
undetectable		 5d0yA-5e4sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e55 CONTACTIN-6

(Mus musculus) 		PF00041
(fn3) 		3 ARG A 856
LYS A 854
GLU A 839
 None
 0.82A 5d0yA-5e55A:
undetectable		 5d0yA-5e55A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		3 ARG A 986
LYS A 976
GLU A 984
 None
 0.65A 5d0yA-5gjvA:
undetectable		 5d0yA-5gjvA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 3 ARG C  23
LYS C  72
GLU C  76
 None
 0.57A 5d0yA-5h9uC:
undetectable		 5d0yA-5h9uC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		3 ARG A 745
LYS A 452
GLU A 456
 None
 0.82A 5d0yA-5hlbA:
undetectable		 5d0yA-5hlbA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Homo sapiens) 		PF00061
(Lipocalin) 		3 ARG A  10
LYS A  55
GLU A  57
 None
 0.81A 5d0yA-5hz5A:
undetectable		 5d0yA-5hz5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ARG A 877
LYS A 910
GLU A 913
 None
 0.59A 5d0yA-5j6sA:
undetectable		 5d0yA-5j6sA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		3 ARG A 191
LYS A 214
GLU A 218
 None
 0.76A 5d0yA-5nvrA:
undetectable		 5d0yA-5nvrA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3p MEMBRANE-ASSOCIATED
PROTEIN SLR1513

(Synechocystis
sp. PCC 6803) 		no annotation 3 ARG A  78
LYS A  22
GLU A  26
 None
 0.77A 5d0yA-5o3pA:
undetectable		 5d0yA-5o3pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		3 ARG A 651
LYS A 644
GLU A 647
 None
 0.76A 5d0yA-5odrA:
undetectable		 5d0yA-5odrA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ARG A 225
LYS A 276
GLU A 278
 None
 0.78A 5d0yA-5t9gA:
undetectable		 5d0yA-5t9gA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u22 N2152

(Neocallimastix
frontalis) 		PF01229
(Glyco_hydro_39) 		3 ARG A 425
LYS A 380
GLU A 382
 None
 0.80A 5d0yA-5u22A:
undetectable		 5d0yA-5u22A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ARG D 670
LYS D 632
GLU D 591
 None
 0.75A 5d0yA-5uheD:
2.6		 5d0yA-5uheD:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		3 ARG A 219
LYS A 210
GLU A 214
 None
 0.76A 5d0yA-5volA:
undetectable		 5d0yA-5volA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x89 ENDA-LIKE
PROTEIN,TRNA-SPLICIN
G ENDONUCLEASE

(Methanopyrus
kandleri) 		no annotation 3 ARG A  72
LYS A  16
GLU A  65
 None
 0.81A 5d0yA-5x89A:
undetectable		 5d0yA-5x89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
yayanosii) 		PF02463
(SMC_N) 		3 ARG A 105
LYS A 103
GLU A  81
 None
 0.81A 5d0yA-5xeiA:
undetectable		 5d0yA-5xeiA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyb -

(-) 		no annotation 3 ARG A 138
LYS A 120
GLU A 124
 None
 0.80A 5d0yA-5xybA:
undetectable		 5d0yA-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1

(Zygosaccharomyces
rouxii) 		no annotation 3 ARG A 415
LYS A 410
GLU A 414
 PO4  A 502 (-3.3A)
None
None
 0.64A 5d0yA-5yk7A:
undetectable		 5d0yA-5yk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 3 ARG A 306
LYS A 313
GLU A 315
 None
 0.80A 5d0yA-5yp3A:
undetectable		 5d0yA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 3 ARG A 986
LYS A 976
GLU A 984
 None
 0.77A 5d0yA-6byoA:
undetectable		 5d0yA-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c49 ALCOHOL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 3 ARG A 130
LYS A 128
GLU A  34
 None
 0.76A 5d0yA-6c49A:
undetectable		 5d0yA-6c49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 3 ARG A1187
LYS A1215
GLU A1177
 None
 0.83A 5d0yA-6cenA:
undetectable		 5d0yA-6cenA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f76 -

(-) 		no annotation 3 ARG B  41
LYS B   5
GLU B   3
 CVK  B 203 (-3.6A)
CVK  B 203 (-3.8A)
CVK  B 203 ( 4.8A)
 0.79A 5d0yA-6f76B:
undetectable		 5d0yA-6f76B:
undetectable