SIMILAR PATTERNS OF AMINO ACIDS FOR 5D0Y_A_FOLA201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajk CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		5 GLY A 158
ASP A 191
PHE A 190
THR A 183
ASN A 102
 None
 1.19A 5d0yA-1ajkA:
undetectable		 5d0yA-1ajkA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		5 LEU A 226
GLN A 222
GLY A 251
ASP A 257
ASN A 220
 None
 1.44A 5d0yA-1bhwA:
0.0		 5d0yA-1bhwA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 585
SER A 577
PHE A 574
ASN A 546
VAL A 524
 None
 1.36A 5d0yA-1ciyA:
2.3		 5d0yA-1ciyA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eh5 PALMITOYL PROTEIN
THIOESTERASE 1

(Bos taurus) 		PF02089
(Palm_thioest) 		5 LEU A 136
GLY A 141
ASP A  43
SER A  50
VAL A  36
 None
 1.42A 5d0yA-1eh5A:
0.0		 5d0yA-1eh5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		5 LEU A 207
GLY A  40
ASN A  80
THR A  75
VAL A 175
 None
 1.27A 5d0yA-1f0iA:
0.2		 5d0yA-1f0iA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP

(Salmonella
enterica) 		PF00102
(Y_phosphatase)
PF03545
(YopE) 		5 LEU S 357
ASN S 402
THR S 430
VAL S 399
HIS S 480
 None
 1.25A 5d0yA-1g4uS:
0.8		 5d0yA-1g4uS:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 LEU B 301
GLY B 211
PHE B 262
THR B 261
TYR B 229
 None
 1.35A 5d0yA-1htrB:
undetectable		 5d0yA-1htrB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igw ISOCITRATE LYASE

(Escherichia
coli) 		PF00463
(ICL) 		5 LEU A 171
GLY A 163
ASP A 187
THR A 233
VAL A 183
 None
 1.35A 5d0yA-1igwA:
0.0		 5d0yA-1igwA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 GLY A 451
ASN A 297
PHE A 294
THR A 290
VAL A 272
 None
 1.30A 5d0yA-1iidA:
0.0		 5d0yA-1iidA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		5 LEU A 369
GLY A 306
THR A 195
ASN A 220
VAL A 219
 None
None
None
CL  A2014 ( 4.3A)
CL  A2001 ( 4.1A)
 1.38A 5d0yA-1itkA:
0.3		 5d0yA-1itkA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE
METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		5 GLN A 395
GLY A 397
PHE A 346
THR A 378
HIS C 158
 MGN  A 400 ( 4.8A)
MGN  A 400 (-3.6A)
None
None
None
 1.46A 5d0yA-1mroA:
1.4		 5d0yA-1mroA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmn ALPHA-1-ANTICHYMOTRY
PSIN

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 184
SER A  53
TYR A 138
ASN A 116
HIS A  93
 None
 1.03A 5d0yA-1qmnA:
undetectable		 5d0yA-1qmnA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfd FAB M82G2, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H 100
ASN H  52
PHE H  29
TYR H 102
VAL H  78
 None
 1.42A 5d0yA-1rfdH:
undetectable		 5d0yA-1rfdH:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuq SUPEROXIDE DISMUTASE

(Bacillus
anthracis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A 131
THR A  71
TYR A  36
VAL A  55
HIS A 169
 None
None
None
None
MN  A 204 (-3.3A)
 1.36A 5d0yA-1xuqA:
undetectable		 5d0yA-1xuqA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		5 LEU A 268
GLY A 272
ASP A 281
THR A 283
VAL A 247
 None
 1.44A 5d0yA-1zefA:
undetectable		 5d0yA-1zefA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7u CHARYBDIN

(Drimia maritima) 		PF00161
(RIP) 		5 LEU A  35
GLY A 241
PHE A  27
THR A  23
VAL A  12
 None
 1.23A 5d0yA-2b7uA:
undetectable		 5d0yA-2b7uA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htd PREDICTED
FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN FROM
COG3576 FAMILY
STRUCTURALLY RELATED
TO PYRIDOXINE
5'-PHOSPHATE OXIDASE

(Lactobacillus
delbrueckii) 		PF01243
(Putative_PNPOx) 		5 LEU A  71
GLY A  39
ASN A  19
TYR A  23
VAL A  82
 None
SO4  A 125 (-3.7A)
None
None
None
 1.20A 5d0yA-2htdA:
undetectable		 5d0yA-2htdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		5 LEU A  95
GLN A  94
GLY A  88
ASN A 148
THR A 219
 None
 1.26A 5d0yA-2incA:
undetectable		 5d0yA-2incA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 LEU A 251
GLY A 196
SER A  17
ASN A  24
HIS A 107
 None
 1.36A 5d0yA-2it4A:
undetectable		 5d0yA-2it4A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnj PUTATIVE
UNCHARACTERIZED
PROTEIN SLL1418

(Synechocystis
sp. PCC 6803) 		PF01789
(PsbP) 		5 GLY A  52
PHE A 162
THR A 161
TYR A  35
VAL A 181
 None
 1.34A 5d0yA-2lnjA:
undetectable		 5d0yA-2lnjA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		5 GLY A 212
SER A 255
PHE A 285
THR A 287
VAL A 283
 None
 1.20A 5d0yA-2paaA:
undetectable		 5d0yA-2paaA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy1 PECTATE LYASE II

(Xanthomonas
campestris) 		PF00544
(Pec_lyase_C) 		5 LEU A 233
GLY A 176
ASN A 222
THR A 188
ASN A 203
 None
 1.19A 5d0yA-2qy1A:
undetectable		 5d0yA-2qy1A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uy3 ENDOCHITINASE

(Saccharomyces
cerevisiae) 		PF00704
(Glyco_hydro_18) 		5 ASP A 194
SER A 196
ASN A 159
TYR A 217
ASN A 216
 None
 1.43A 5d0yA-2uy3A:
undetectable		 5d0yA-2uy3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00657
(Lipase_GDSL) 		5 LEU A  91
GLY A 106
SER A 111
PHE A  38
VAL A  59
 None
IOD  A1347 ( 4.1A)
None
None
None
 1.34A 5d0yA-2wabA:
undetectable		 5d0yA-2wabA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqs AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF16364
(Antigen_C) 		5 LEU A1111
GLN A1113
GLY A1116
ASN A1241
TYR A1201
 None
 1.36A 5d0yA-2wqsA:
undetectable		 5d0yA-2wqsA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 LEU A 388
GLY A 668
ASP A 657
PHE A 656
TYR A 641
 None
 1.37A 5d0yA-2x05A:
undetectable		 5d0yA-2x05A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE

(Thermotoga
maritima) 		PF00483
(NTP_transferase) 		5 LEU A 187
SER A 237
PHE A 168
TYR A 151
VAL A 165
 None
 1.45A 5d0yA-2x60A:
undetectable		 5d0yA-2x60A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		5 GLN A 291
GLY A 289
ASP A 664
SER A 666
ASN A 317
 None
None
CA  A1712 ( 4.2A)
None
CA  A1712 (-2.9A)
 1.43A 5d0yA-2yfsA:
undetectable		 5d0yA-2yfsA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrp NUCLEAR FACTOR OF
ACTIVATED T-CELLS,
CYTOPLASMIC 4

(Homo sapiens) 		PF16179
(RHD_dimer) 		5 LEU A  62
GLN A  63
SER A  15
THR A  30
ASN A  65
 None
 1.43A 5d0yA-2yrpA:
undetectable		 5d0yA-2yrpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aly PUTATIVE
UNCHARACTERIZED
PROTEIN ST0753

(Sulfurisphaera
tokodaii) 		PF13456
(RVT_3) 		5 LEU A 113
GLY A   4
ASP A 125
SER A 128
VAL A  80
 None
 1.42A 5d0yA-3alyA:
undetectable		 5d0yA-3alyA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF13377
(Peripla_BP_3) 		5 LEU A 124
GLY A 150
ASP A 274
PHE A  75
VAL A  68
 None
None
GOL  A 500 (-2.8A)
GOL  A 500 (-4.5A)
None
 1.47A 5d0yA-3clkA:
undetectable		 5d0yA-3clkA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		5 ASP A 261
SER A 223
PHE A 260
ASN A 251
VAL A 249
 None
 1.28A 5d0yA-3f6tA:
undetectable		 5d0yA-3f6tA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 GLY A 186
ASP A 243
SER A 217
THR A 283
HIS A 225
 None
 1.45A 5d0yA-3gq9A:
undetectable		 5d0yA-3gq9A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjn THYMIDYLATE KINASE

(Thermotoga
maritima) 		PF02223
(Thymidylate_kin) 		5 LEU A  63
GLY A  38
ASP A   9
ASN A 143
PHE A 145
 None
None
TYD  A 401 (-2.9A)
TYD  A 401 (-3.2A)
TYD  A 401 (-4.0A)
 1.28A 5d0yA-3hjnA:
undetectable		 5d0yA-3hjnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4e ISOCITRATE LYASE

(Burkholderia
pseudomallei) 		PF00463
(ICL) 		5 LEU A 168
GLY A 160
ASP A 184
THR A 230
VAL A 180
 None
 1.40A 5d0yA-3i4eA:
undetectable		 5d0yA-3i4eA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 184
GLY A 178
SER A 143
ASN A 208
VAL A 350
 None
 1.15A 5d0yA-3ic9A:
undetectable		 5d0yA-3ic9A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		5 GLN A 124
GLY A 329
TYR A 333
ASN A 246
VAL A 223
 None
 1.46A 5d0yA-3ipcA:
undetectable		 5d0yA-3ipcA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis) 		PF00463
(ICL) 		5 LEU A 172
GLY A 164
ASP A 188
THR A 234
VAL A 184
 None
 1.35A 5d0yA-3lg3A:
undetectable		 5d0yA-3lg3A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)

(Cupriavidus
metallidurans) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		5 ASN A  45
PHE A 280
THR A 229
TYR A 223
VAL A 259
 None
 1.29A 5d0yA-3lnnA:
undetectable		 5d0yA-3lnnA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 LEU A 114
GLY A  66
PHE A 129
THR A 168
VAL A 121
 None
EDO  A 263 (-3.3A)
None
GOL  A 265 (-2.9A)
None
 1.24A 5d0yA-3moyA:
undetectable		 5d0yA-3moyA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		5 GLY A 480
THR A 181
TYR A 457
VAL A  15
HIS A 489
 None
 1.23A 5d0yA-3ob8A:
undetectable		 5d0yA-3ob8A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Staphylococcus
aureus) 		PF13561
(adh_short_C2) 		5 LEU A 139
GLY A  11
ASN A 119
ASN A 113
VAL A 161
 MG  A 257 ( 4.8A)
PEG  A 250 ( 3.9A)
None
None
None
 1.14A 5d0yA-3osuA:
undetectable		 5d0yA-3osuA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm3 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Campylobacter
jejuni) 		PF01116
(F_bP_aldolase) 		5 GLY A 222
ASN A  62
THR A 103
ASN A  35
VAL A  37
 None
 1.14A 5d0yA-3qm3A:
undetectable		 5d0yA-3qm3A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7w EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
nitratireducens) 		PF02335
(Cytochrom_C552) 		5 SER A 487
PHE A 367
THR A 366
ASN A 293
VAL A 377
 None
HEC  A1007 (-4.3A)
None
None
HEC  A1008 ( 4.2A)
 1.45A 5d0yA-3s7wA:
undetectable		 5d0yA-3s7wA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 GLY A 186
ASP A 243
SER A 217
THR A 283
HIS A 225
 None
None
None
MG  A 857 ( 4.9A)
None
 1.46A 5d0yA-3sucA:
undetectable		 5d0yA-3sucA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		5 SER A 487
PHE A 367
THR A 366
ASN A 293
VAL A 377
 None
HEC  A1007 (-4.3A)
None
HEC  A1007 ( 4.8A)
HEC  A1008 (-4.3A)
 1.41A 5d0yA-3ttbA:
undetectable		 5d0yA-3ttbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 GLY A 333
ASP A 243
ASN A 266
THR A 245
VAL A 249
 None
CA  A2001 (-2.7A)
NAG  A2008 (-1.9A)
CA  A2001 (-4.8A)
None
 0.87A 5d0yA-3vi3A:
undetectable		 5d0yA-3vi3A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsc PECTATE
TRISACCHARIDE-LYASE

(Thermotoga
maritima) 		PF00544
(Pec_lyase_C) 		5 GLY A   8
ASN A  92
THR A  71
VAL A 121
HIS A 187
 None
 1.20A 5d0yA-3zscA:
undetectable		 5d0yA-3zscA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 GLN A 627
GLY A 606
TYR A 589
ASN A 632
VAL A 359
 None
 1.21A 5d0yA-4a2lA:
undetectable		 5d0yA-4a2lA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PYRIDOXINE
BIOSYNTHETIC ENZYME
PDX1 HOMOLOGUE,
PUTATIVE

(Plasmodium
berghei) 		PF01680
(SOR_SNZ) 		5 LEU A 139
GLY A 145
ASP A 105
SER A 107
HIS A  14
 None
 1.26A 5d0yA-4adsA:
undetectable		 5d0yA-4adsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 LEU A 186
GLY A 191
ASP A   7
SER A  47
ASN A 198
 None
 1.26A 5d0yA-4e4gA:
undetectable		 5d0yA-4e4gA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbh PROTEIN SYNTHESIS
INHIBITOR I

(Hordeum vulgare) 		PF00161
(RIP) 		5 LEU A 169
GLY A 134
PHE A  30
THR A  29
VAL A  66
 None
 1.17A 5d0yA-4fbhA:
undetectable		 5d0yA-4fbhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		5 LEU A 204
GLY A 210
ASP A 318
THR A 322
VAL A 215
 None
 1.32A 5d0yA-4fj6A:
undetectable		 5d0yA-4fj6A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5b DR_1245 PROTEIN

(Deinococcus
radiodurans) 		PF10722
(YbjN) 		5 LEU A 102
ASP A 120
PHE A 123
TYR A 104
VAL A  46
 None
 1.37A 5d0yA-4h5bA:
undetectable		 5d0yA-4h5bA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA
NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas sp.
C18;
Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		5 ASP A 361
SER A 215
ASN B 106
ASN B 188
VAL B 191
 None
None
None
None
EDO  B 201 (-4.5A)
 1.47A 5d0yA-4hjlA:
undetectable		 5d0yA-4hjlA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 LEU A 373
GLY A 410
SER A 391
PHE A 380
THR A 382
 None
 1.25A 5d0yA-4igdA:
undetectable		 5d0yA-4igdA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 LEU A 281
PHE A 254
TYR A 317
ASN A 320
VAL A 322
 None
 1.17A 5d0yA-4jclA:
undetectable		 5d0yA-4jclA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jde PROTEIN F15E11.1

(Caenorhabditis
elegans) 		no annotation 5 LEU B  31
GLY B  77
PHE B 138
THR B 146
HIS B 152
 None
 1.18A 5d0yA-4jdeB:
undetectable		 5d0yA-4jdeB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica;
Salmonella
enterica) 		PF03372
(Exo_endo_phos)
PF02917
(Pertussis_S1) 		5 GLY F 152
PHE G 103
THR G 177
ASN G 144
HIS F 187
 None
 1.26A 5d0yA-4k6lF:
undetectable		 5d0yA-4k6lF:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		5 ASN B  93
THR B 256
ASN B 143
VAL B 141
HIS B 213
 None
PYC  B 904 (-4.3A)
None
None
None
 1.34A 5d0yA-4k7gB:
undetectable		 5d0yA-4k7gB:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 GLY D 907
PHE D 138
THR D 139
ASN D 136
HIS D 896
 None
 1.26A 5d0yA-4ngeD:
undetectable		 5d0yA-4ngeD:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6q HASAP

(Pseudomonas
aeruginosa) 		PF06438
(HasA) 		5 LEU A  20
GLY A 143
ASP A  64
THR A  97
VAL A 114
 None
 1.33A 5d0yA-4o6qA:
undetectable		 5d0yA-4o6qA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		5 LEU A 178
ASP A  22
THR A  24
TYR A 220
ASN A 222
 None
 1.43A 5d0yA-4o8uA:
undetectable		 5d0yA-4o8uA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		5 LEU A 214
GLN A 213
GLY A 340
ASN A 293
VAL A 216
 None
FMN  A 401 (-3.0A)
None
EDO  A 403 ( 3.7A)
None
 1.36A 5d0yA-4rnwA:
undetectable		 5d0yA-4rnwA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		5 LEU A 363
GLN A 362
GLY A  90
ASN A  43
VAL A 365
 None
FMN  A 501 (-3.0A)
None
FMN  A 501 (-4.2A)
None
 1.33A 5d0yA-4rnxA:
undetectable		 5d0yA-4rnxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF00551
(Formyl_trans_N) 		5 GLY A  12
ASN A 100
THR A 129
TYR A 168
VAL A 175
 CL  A 202 (-3.7A)
CL  A 201 ( 4.1A)
None
None
None
 1.16A 5d0yA-4s1nA:
undetectable		 5d0yA-4s1nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP) 		5 GLY A 333
ASP A 243
ASN A 266
THR A 245
VAL A 249
 None
CA  A 501 (-2.7A)
NAG  A 519 (-1.6A)
None
None
 0.93A 5d0yA-4wk4A:
undetectable		 5d0yA-4wk4A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa9 GALA PROTEIN TYPE 1,
3 OR 4

(Legionella
pneumophila) 		PF13516
(LRR_6) 		5 LEU A  16
GLN A  18
GLY A  11
SER A  74
ASN A  72
 None
 1.30A 5d0yA-4xa9A:
undetectable		 5d0yA-4xa9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		5 LEU A 115
GLN A 114
GLY A 241
ASN A 194
VAL A 117
 None
FMN  A 401 (-2.9A)
None
4EG  A 402 ( 3.0A)
None
 1.31A 5d0yA-4yncA:
undetectable		 5d0yA-4yncA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 506
GLY A 483
PHE A 466
THR A 464
ASN A 504
 None
 1.14A 5d0yA-5a7mA:
undetectable		 5d0yA-5a7mA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avp L-RIBOSE ISOMERASE

(Geodermatophilus
obscurus) 		no annotation 5 LEU A 204
ASP A  96
SER A  72
TYR A 119
HIS A 192
 None
None
None
None
MN  A 401 (-3.5A)
 1.35A 5d0yA-5avpA:
undetectable		 5d0yA-5avpA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		5 LEU A  78
ASP A  84
ASN A  82
PHE A  83
VAL A 121
 None
 1.13A 5d0yA-5cb2A:
3.5		 5d0yA-5cb2A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLY A  70
ASP A 447
PHE A 448
ASN A 180
VAL A 182
 None
 1.26A 5d0yA-5cwaA:
undetectable		 5d0yA-5cwaA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5drz HIV ANTIBODY F240
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 GLY H  54
PHE H  29
THR H  28
TYR H  33
VAL H  78
 None
 1.26A 5d0yA-5drzH:
undetectable		 5d0yA-5drzH:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		5 GLY A 298
PHE A 137
THR A 138
TYR A 439
VAL A 432
 MPG  A 605 (-3.9A)
None
None
None
None
 1.11A 5d0yA-5f15A:
2.8		 5d0yA-5f15A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fre EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF02973
(Sialidase) 		5 LEU A 109
ASN A 122
TYR A  65
VAL A  37
HIS A  93
 None
None
SIA  A 201 (-4.0A)
None
SIA  A 201 ( 4.8A)
 1.41A 5d0yA-5freA:
undetectable		 5d0yA-5freA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		5 LEU A 224
SER A 191
ASN A 214
PHE A 245
THR A 210
 None
 1.43A 5d0yA-5g5nA:
undetectable		 5d0yA-5g5nA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		5 LEU A 224
SER A 191
ASN A 214
PHE A 245
THR A 246
 None
 1.36A 5d0yA-5g5nA:
undetectable		 5d0yA-5g5nA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggy IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 LEU A  64
GLY A 297
PHE A 164
THR A 162
VAL A  56
 None
 1.43A 5d0yA-5ggyA:
undetectable		 5d0yA-5ggyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0k UNCHARACTERIZED
PROTEIN

(Pedobacter
heparinus) 		PF16265
(DUF4918) 		5 GLY A  61
PHE A 130
THR A 131
TYR A 145
VAL A 154
 None
 1.17A 5d0yA-5h0kA:
undetectable		 5d0yA-5h0kA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqw PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		5 GLY A2428
SER A2464
PHE A2494
THR A2495
VAL A2258
 None
 1.27A 5d0yA-5hqwA:
undetectable		 5d0yA-5hqwA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 LEU A 351
GLY A 700
ASP A 366
ASN A 349
VAL A 393
 None
 1.28A 5d0yA-5i2tA:
undetectable		 5d0yA-5i2tA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i77 ENDO-BETA-1,
4-GLUCANASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		5 LEU A  84
GLY A  91
PHE A 136
THR A 133
TYR A 125
 None
 1.47A 5d0yA-5i77A:
undetectable		 5d0yA-5i77A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw PUTATIVE
ANGIOTENSINOGEN

(Lampetra
fluviatilis) 		PF00079
(Serpin) 		5 LEU A 194
GLY A 158
SER A 108
ASN A 173
VAL A 118
 None
 1.44A 5d0yA-5inwA:
undetectable		 5d0yA-5inwA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase)
PF00515
(TPR_1) 		5 LEU A   9
GLY A  59
ASP A  14
SER A 187
VAL A 170
 None
 1.24A 5d0yA-5jheA:
2.4		 5d0yA-5jheA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		5 GLN A 257
GLY A 221
PHE A 310
THR A 324
HIS A 192
 None
 1.39A 5d0yA-5jjpA:
undetectable		 5d0yA-5jjpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 5 GLN A 536
GLY A  35
SER A 161
PHE A 165
ASN A 534
 None
 1.34A 5d0yA-5kk5A:
2.2		 5d0yA-5kk5A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A  78
GLY A  84
ASN A  88
PHE A 486
VAL A 189
 None
 1.21A 5d0yA-5l6fA:
undetectable		 5d0yA-5l6fA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLN A 620
GLY A 618
ASP A 381
SER A 573
ASN A 575
 None
None
None
None
FAD  A 701 ( 3.6A)
 1.41A 5d0yA-5nccA:
undetectable		 5d0yA-5nccA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		5 LEU A   4
ASP A  21
PHE A  20
ASN A   2
VAL A  58
 None
 1.46A 5d0yA-5nckA:
undetectable		 5d0yA-5nckA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 5 LEU A 249
GLY A 256
ASN A 284
PHE A 343
THR A 344
 None
 1.36A 5d0yA-5nfgA:
undetectable		 5d0yA-5nfgA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASP A 258
THR A 304
ASN A 316
VAL A 311
HIS A 264
 None
None
None
None
AHR  A 901 (-3.9A)
 1.45A 5d0yA-5opjA:
undetectable		 5d0yA-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		5 LEU A1000
GLY A 861
ASP A 925
PHE A 992
VAL A 980
 None
MJ8  A1601 ( 4.7A)
None
None
None
 1.42A 5d0yA-5u89A:
undetectable		 5d0yA-5u89A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8c TRANSCRIPTIONAL
REGULATOR

(Actinomyces
oris) 		no annotation 5 LEU A 240
GLY A 221
PHE A 197
THR A 199
VAL A 273
 None
 1.42A 5d0yA-5v8cA:
undetectable		 5d0yA-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 GLY B 645
ASP B 511
SER B 513
THR B 639
TYR B 673
 None
 1.36A 5d0yA-5vniB:
undetectable		 5d0yA-5vniB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ

(Mycobacterium
tuberculosis) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
PF12680
(SnoaL_2) 		5 GLY A 250
ASP A  88
THR A  90
VAL A  96
HIS A 171
 None
 1.39A 5d0yA-5xe7A:
undetectable		 5d0yA-5xe7A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE

(Thermus
thermophilus) 		PF01546
(Peptidase_M20) 		5 LEU A 306
SER A 322
THR A 298
TYR A 269
ASN A 304
 None
 1.19A 5d0yA-5xoyA:
undetectable		 5d0yA-5xoyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 5 SER A 674
PHE A 930
THR A 924
VAL A 810
HIS A 917
 None
 1.26A 5d0yA-6bfuA:
undetectable		 5d0yA-6bfuA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		5 GLN G 178
GLY G 151
THR F 187
TYR G 129
VAL F 138
 None
 1.11A 5d0yA-6cnkG:
undetectable		 5d0yA-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3i -

(-) 		no annotation 5 LEU A  83
GLY A 107
PHE A 171
THR A 168
HIS A 270
 None
AKG  A 302 (-3.1A)
None
None
CO  A 301 (-3.2A)
 1.36A 5d0yA-6d3iA:
undetectable		 5d0yA-6d3iA:
undetectable