SIMILAR PATTERNS OF AMINO ACIDS FOR 5D0Y_A_FOLA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajk CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		5 GLY A 158
ASP A 191
PHE A 190
THR A 183
ASN A 102
 None
 1.19A 5d0yA-1ajkA:
undetectable		 5d0yA-1ajkA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		5 LEU A 226
GLN A 222
GLY A 251
ASP A 257
ASN A 220
 None
 1.44A 5d0yA-1bhwA:
0.0		 5d0yA-1bhwA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 585
SER A 577
PHE A 574
ASN A 546
VAL A 524
 None
 1.36A 5d0yA-1ciyA:
2.3		 5d0yA-1ciyA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eh5 PALMITOYL PROTEIN
THIOESTERASE 1

(Bos taurus) 		PF02089
(Palm_thioest) 		5 LEU A 136
GLY A 141
ASP A  43
SER A  50
VAL A  36
 None
 1.42A 5d0yA-1eh5A:
0.0		 5d0yA-1eh5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0i PHOSPHOLIPASE D

(Streptomyces
sp. PMF) 		PF13091
(PLDc_2) 		5 LEU A 207
GLY A  40
ASN A  80
THR A  75
VAL A 175
 None
 1.27A 5d0yA-1f0iA:
0.2		 5d0yA-1f0iA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP

(Salmonella
enterica) 		PF00102
(Y_phosphatase)
PF03545
(YopE) 		5 LEU S 357
ASN S 402
THR S 430
VAL S 399
HIS S 480
 None
 1.25A 5d0yA-1g4uS:
0.8		 5d0yA-1g4uS:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 LEU B 301
GLY B 211
PHE B 262
THR B 261
TYR B 229
 None
 1.35A 5d0yA-1htrB:
undetectable		 5d0yA-1htrB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igw ISOCITRATE LYASE

(Escherichia
coli) 		PF00463
(ICL) 		5 LEU A 171
GLY A 163
ASP A 187
THR A 233
VAL A 183
 None
 1.35A 5d0yA-1igwA:
0.0		 5d0yA-1igwA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 GLY A 451
ASN A 297
PHE A 294
THR A 290
VAL A 272
 None
 1.30A 5d0yA-1iidA:
0.0		 5d0yA-1iidA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		5 LEU A 369
GLY A 306
THR A 195
ASN A 220
VAL A 219
 None
None
None
CL  A2014 ( 4.3A)
CL  A2001 ( 4.1A)
 1.38A 5d0yA-1itkA:
0.3		 5d0yA-1itkA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE
METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis;
Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		5 GLN A 395
GLY A 397
PHE A 346
THR A 378
HIS C 158
 MGN  A 400 ( 4.8A)
MGN  A 400 (-3.6A)
None
None
None
 1.46A 5d0yA-1mroA:
1.4		 5d0yA-1mroA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmn ALPHA-1-ANTICHYMOTRY
PSIN

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 184
SER A  53
TYR A 138
ASN A 116
HIS A  93
 None
 1.03A 5d0yA-1qmnA:
undetectable		 5d0yA-1qmnA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfd FAB M82G2, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H 100
ASN H  52
PHE H  29
TYR H 102
VAL H  78
 None
 1.42A 5d0yA-1rfdH:
undetectable		 5d0yA-1rfdH:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuq SUPEROXIDE DISMUTASE

(Bacillus
anthracis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A 131
THR A  71
TYR A  36
VAL A  55
HIS A 169
 None
None
None
None
MN  A 204 (-3.3A)
 1.36A 5d0yA-1xuqA:
undetectable		 5d0yA-1xuqA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		5 LEU A 268
GLY A 272
ASP A 281
THR A 283
VAL A 247
 None
 1.44A 5d0yA-1zefA:
undetectable		 5d0yA-1zefA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7u CHARYBDIN

(Drimia maritima) 		PF00161
(RIP) 		5 LEU A  35
GLY A 241
PHE A  27
THR A  23
VAL A  12
 None
 1.23A 5d0yA-2b7uA:
undetectable		 5d0yA-2b7uA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htd PREDICTED
FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN FROM
COG3576 FAMILY
STRUCTURALLY RELATED
TO PYRIDOXINE
5'-PHOSPHATE OXIDASE

(Lactobacillus
delbrueckii) 		PF01243
(Putative_PNPOx) 		5 LEU A  71
GLY A  39
ASN A  19
TYR A  23
VAL A  82
 None
SO4  A 125 (-3.7A)
None
None
None
 1.20A 5d0yA-2htdA:
undetectable		 5d0yA-2htdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		5 LEU A  95
GLN A  94
GLY A  88
ASN A 148
THR A 219
 None
 1.26A 5d0yA-2incA:
undetectable		 5d0yA-2incA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 LEU A 251
GLY A 196
SER A  17
ASN A  24
HIS A 107
 None
 1.36A 5d0yA-2it4A:
undetectable		 5d0yA-2it4A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnj PUTATIVE
UNCHARACTERIZED
PROTEIN SLL1418

(Synechocystis
sp. PCC 6803) 		PF01789
(PsbP) 		5 GLY A  52
PHE A 162
THR A 161
TYR A  35
VAL A 181
 None
 1.34A 5d0yA-2lnjA:
undetectable		 5d0yA-2lnjA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		5 GLY A 212
SER A 255
PHE A 285
THR A 287
VAL A 283
 None
 1.20A 5d0yA-2paaA:
undetectable		 5d0yA-2paaA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy1 PECTATE LYASE II

(Xanthomonas
campestris) 		PF00544
(Pec_lyase_C) 		5 LEU A 233
GLY A 176
ASN A 222
THR A 188
ASN A 203
 None
 1.19A 5d0yA-2qy1A:
undetectable		 5d0yA-2qy1A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uy3 ENDOCHITINASE

(Saccharomyces
cerevisiae) 		PF00704
(Glyco_hydro_18) 		5 ASP A 194
SER A 196
ASN A 159
TYR A 217
ASN A 216
 None
 1.43A 5d0yA-2uy3A:
undetectable		 5d0yA-2uy3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00657
(Lipase_GDSL) 		5 LEU A  91
GLY A 106
SER A 111
PHE A  38
VAL A  59
 None
IOD  A1347 ( 4.1A)
None
None
None
 1.34A 5d0yA-2wabA:
undetectable		 5d0yA-2wabA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqs AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF16364
(Antigen_C) 		5 LEU A1111
GLN A1113
GLY A1116
ASN A1241
TYR A1201
 None
 1.36A 5d0yA-2wqsA:
undetectable		 5d0yA-2wqsA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 LEU A 388
GLY A 668
ASP A 657
PHE A 656
TYR A 641
 None
 1.37A 5d0yA-2x05A:
undetectable		 5d0yA-2x05A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE

(Thermotoga
maritima) 		PF00483
(NTP_transferase) 		5 LEU A 187
SER A 237
PHE A 168
TYR A 151
VAL A 165
 None
 1.45A 5d0yA-2x60A:
undetectable		 5d0yA-2x60A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		5 GLN A 291
GLY A 289
ASP A 664
SER A 666
ASN A 317
 None
None
CA  A1712 ( 4.2A)
None
CA  A1712 (-2.9A)
 1.43A 5d0yA-2yfsA:
undetectable		 5d0yA-2yfsA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrp NUCLEAR FACTOR OF
ACTIVATED T-CELLS,
CYTOPLASMIC 4

(Homo sapiens) 		PF16179
(RHD_dimer) 		5 LEU A  62
GLN A  63
SER A  15
THR A  30
ASN A  65
 None
 1.43A 5d0yA-2yrpA:
undetectable		 5d0yA-2yrpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aly PUTATIVE
UNCHARACTERIZED
PROTEIN ST0753

(Sulfurisphaera
tokodaii) 		PF13456
(RVT_3) 		5 LEU A 113
GLY A   4
ASP A 125
SER A 128
VAL A  80
 None
 1.42A 5d0yA-3alyA:
undetectable		 5d0yA-3alyA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clk TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF13377
(Peripla_BP_3) 		5 LEU A 124
GLY A 150
ASP A 274
PHE A  75
VAL A  68
 None
None
GOL  A 500 (-2.8A)
GOL  A 500 (-4.5A)
None
 1.47A 5d0yA-3clkA:
undetectable		 5d0yA-3clkA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		5 ASP A 261
SER A 223
PHE A 260
ASN A 251
VAL A 249
 None
 1.28A 5d0yA-3f6tA:
undetectable		 5d0yA-3f6tA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 GLY A 186
ASP A 243
SER A 217
THR A 283
HIS A 225
 None
 1.45A 5d0yA-3gq9A:
undetectable		 5d0yA-3gq9A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjn THYMIDYLATE KINASE

(Thermotoga
maritima) 		PF02223
(Thymidylate_kin) 		5 LEU A  63
GLY A  38
ASP A   9
ASN A 143
PHE A 145
 None
None
TYD  A 401 (-2.9A)
TYD  A 401 (-3.2A)
TYD  A 401 (-4.0A)
 1.28A 5d0yA-3hjnA:
undetectable		 5d0yA-3hjnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4e ISOCITRATE LYASE

(Burkholderia
pseudomallei) 		PF00463
(ICL) 		5 LEU A 168
GLY A 160
ASP A 184
THR A 230
VAL A 180
 None
 1.40A 5d0yA-3i4eA:
undetectable		 5d0yA-3i4eA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 184
GLY A 178
SER A 143
ASN A 208
VAL A 350
 None
 1.15A 5d0yA-3ic9A:
undetectable		 5d0yA-3ic9A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		5 GLN A 124
GLY A 329
TYR A 333
ASN A 246
VAL A 223
 None
 1.46A 5d0yA-3ipcA:
undetectable		 5d0yA-3ipcA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis) 		PF00463
(ICL) 		5 LEU A 172
GLY A 164
ASP A 188
THR A 234
VAL A 184
 None
 1.35A 5d0yA-3lg3A:
undetectable		 5d0yA-3lg3A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)

(Cupriavidus
metallidurans) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		5 ASN A  45
PHE A 280
THR A 229
TYR A 223
VAL A 259
 None
 1.29A 5d0yA-3lnnA:
undetectable		 5d0yA-3lnnA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 LEU A 114
GLY A  66
PHE A 129
THR A 168
VAL A 121
 None
EDO  A 263 (-3.3A)
None
GOL  A 265 (-2.9A)
None
 1.24A 5d0yA-3moyA:
undetectable		 5d0yA-3moyA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		5 GLY A 480
THR A 181
TYR A 457
VAL A  15
HIS A 489
 None
 1.23A 5d0yA-3ob8A:
undetectable		 5d0yA-3ob8A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osu 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Staphylococcus
aureus) 		PF13561
(adh_short_C2) 		5 LEU A 139
GLY A  11
ASN A 119
ASN A 113
VAL A 161
 MG  A 257 ( 4.8A)
PEG  A 250 ( 3.9A)
None
None
None
 1.14A 5d0yA-3osuA:
undetectable		 5d0yA-3osuA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm3 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Campylobacter
jejuni) 		PF01116
(F_bP_aldolase) 		5 GLY A 222
ASN A  62
THR A 103
ASN A  35
VAL A  37
 None
 1.14A 5d0yA-3qm3A:
undetectable		 5d0yA-3qm3A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7w EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
nitratireducens) 		PF02335
(Cytochrom_C552) 		5 SER A 487
PHE A 367
THR A 366
ASN A 293
VAL A 377
 None
HEC  A1007 (-4.3A)
None
None
HEC  A1008 ( 4.2A)
 1.45A 5d0yA-3s7wA:
undetectable		 5d0yA-3s7wA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 GLY A 186
ASP A 243
SER A 217
THR A 283
HIS A 225
 None
None
None
MG  A 857 ( 4.9A)
None
 1.46A 5d0yA-3sucA:
undetectable		 5d0yA-3sucA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		5 SER A 487
PHE A 367
THR A 366
ASN A 293
VAL A 377
 None
HEC  A1007 (-4.3A)
None
HEC  A1007 ( 4.8A)
HEC  A1008 (-4.3A)
 1.41A 5d0yA-3ttbA:
undetectable		 5d0yA-3ttbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 GLY A 333
ASP A 243
ASN A 266
THR A 245
VAL A 249
 None
CA  A2001 (-2.7A)
NAG  A2008 (-1.9A)
CA  A2001 (-4.8A)
None
 0.87A 5d0yA-3vi3A:
undetectable		 5d0yA-3vi3A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsc PECTATE
TRISACCHARIDE-LYASE

(Thermotoga
maritima) 		PF00544
(Pec_lyase_C) 		5 GLY A   8
ASN A  92
THR A  71
VAL A 121
HIS A 187
 None
 1.20A 5d0yA-3zscA:
undetectable		 5d0yA-3zscA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 GLN A 627
GLY A 606
TYR A 589
ASN A 632
VAL A 359
 None
 1.21A 5d0yA-4a2lA:
undetectable		 5d0yA-4a2lA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PYRIDOXINE
BIOSYNTHETIC ENZYME
PDX1 HOMOLOGUE,
PUTATIVE

(Plasmodium
berghei) 		PF01680
(SOR_SNZ) 		5 LEU A 139
GLY A 145
ASP A 105
SER A 107
HIS A  14
 None
 1.26A 5d0yA-4adsA:
undetectable		 5d0yA-4adsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 LEU A 186
GLY A 191
ASP A   7
SER A  47
ASN A 198
 None
 1.26A 5d0yA-4e4gA:
undetectable		 5d0yA-4e4gA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbh PROTEIN SYNTHESIS
INHIBITOR I

(Hordeum vulgare) 		PF00161
(RIP) 		5 LEU A 169
GLY A 134
PHE A  30
THR A  29
VAL A  66
 None
 1.17A 5d0yA-4fbhA:
undetectable		 5d0yA-4fbhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		5 LEU A 204
GLY A 210
ASP A 318
THR A 322
VAL A 215
 None
 1.32A 5d0yA-4fj6A:
undetectable		 5d0yA-4fj6A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5b DR_1245 PROTEIN

(Deinococcus
radiodurans) 		PF10722
(YbjN) 		5 LEU A 102
ASP A 120
PHE A 123
TYR A 104
VAL A  46
 None
 1.37A 5d0yA-4h5bA:
undetectable		 5d0yA-4h5bA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA
NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas sp.
C18;
Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		5 ASP A 361
SER A 215
ASN B 106
ASN B 188
VAL B 191
 None
None
None
None
EDO  B 201 (-4.5A)
 1.47A 5d0yA-4hjlA:
undetectable		 5d0yA-4hjlA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 LEU A 373
GLY A 410
SER A 391
PHE A 380
THR A 382
 None
 1.25A 5d0yA-4igdA:
undetectable		 5d0yA-4igdA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 LEU A 281
PHE A 254
TYR A 317
ASN A 320
VAL A 322
 None
 1.17A 5d0yA-4jclA:
undetectable		 5d0yA-4jclA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jde PROTEIN F15E11.1

(Caenorhabditis
elegans) 		no annotation 5 LEU B  31
GLY B  77
PHE B 138
THR B 146
HIS B 152
 None
 1.18A 5d0yA-4jdeB:
undetectable		 5d0yA-4jdeB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG
PUTATIVE
PERTUSSIS-LIKE TOXIN
SUBUNIT

(Salmonella
enterica;
Salmonella
enterica) 		PF03372
(Exo_endo_phos)
PF02917
(Pertussis_S1) 		5 GLY F 152
PHE G 103
THR G 177
ASN G 144
HIS F 187
 None
 1.26A 5d0yA-4k6lF:
undetectable		 5d0yA-4k6lF:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		5 ASN B  93
THR B 256
ASN B 143
VAL B 141
HIS B 213
 None
PYC  B 904 (-4.3A)
None
None
None
 1.34A 5d0yA-4k7gB:
undetectable		 5d0yA-4k7gB:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 GLY D 907
PHE D 138
THR D 139
ASN D 136
HIS D 896
 None
 1.26A 5d0yA-4ngeD:
undetectable		 5d0yA-4ngeD:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6q HASAP

(Pseudomonas
aeruginosa) 		PF06438
(HasA) 		5 LEU A  20
GLY A 143
ASP A  64
THR A  97
VAL A 114
 None
 1.33A 5d0yA-4o6qA:
undetectable		 5d0yA-4o6qA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		5 LEU A 178
ASP A  22
THR A  24
TYR A 220
ASN A 222
 None
 1.43A 5d0yA-4o8uA:
undetectable		 5d0yA-4o8uA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		5 LEU A 214
GLN A 213
GLY A 340
ASN A 293
VAL A 216
 None
FMN  A 401 (-3.0A)
None
EDO  A 403 ( 3.7A)
None
 1.36A 5d0yA-4rnwA:
undetectable		 5d0yA-4rnwA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		5 LEU A 363
GLN A 362
GLY A  90
ASN A  43
VAL A 365
 None
FMN  A 501 (-3.0A)
None
FMN  A 501 (-4.2A)
None
 1.33A 5d0yA-4rnxA:
undetectable		 5d0yA-4rnxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF00551
(Formyl_trans_N) 		5 GLY A  12
ASN A 100
THR A 129
TYR A 168
VAL A 175
 CL  A 202 (-3.7A)
CL  A 201 ( 4.1A)
None
None
None
 1.16A 5d0yA-4s1nA:
undetectable		 5d0yA-4s1nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP) 		5 GLY A 333
ASP A 243
ASN A 266
THR A 245
VAL A 249
 None
CA  A 501 (-2.7A)
NAG  A 519 (-1.6A)
None
None
 0.93A 5d0yA-4wk4A:
undetectable		 5d0yA-4wk4A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa9 GALA PROTEIN TYPE 1,
3 OR 4

(Legionella
pneumophila) 		PF13516
(LRR_6) 		5 LEU A  16
GLN A  18
GLY A  11
SER A  74
ASN A  72
 None
 1.30A 5d0yA-4xa9A:
undetectable		 5d0yA-4xa9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		5 LEU A 115
GLN A 114
GLY A 241
ASN A 194
VAL A 117
 None
FMN  A 401 (-2.9A)
None
4EG  A 402 ( 3.0A)
None
 1.31A 5d0yA-4yncA:
undetectable		 5d0yA-4yncA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 506
GLY A 483
PHE A 466
THR A 464
ASN A 504
 None
 1.14A 5d0yA-5a7mA:
undetectable		 5d0yA-5a7mA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avp L-RIBOSE ISOMERASE

(Geodermatophilus
obscurus) 		no annotation 5 LEU A 204
ASP A  96
SER A  72
TYR A 119
HIS A 192
 None
None
None
None
MN  A 401 (-3.5A)
 1.35A 5d0yA-5avpA:
undetectable		 5d0yA-5avpA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		5 LEU A  78
ASP A  84
ASN A  82
PHE A  83
VAL A 121
 None
 1.13A 5d0yA-5cb2A:
3.5		 5d0yA-5cb2A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLY A  70
ASP A 447
PHE A 448
ASN A 180
VAL A 182
 None
 1.26A 5d0yA-5cwaA:
undetectable		 5d0yA-5cwaA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5drz HIV ANTIBODY F240
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 GLY H  54
PHE H  29
THR H  28
TYR H  33
VAL H  78
 None
 1.26A 5d0yA-5drzH:
undetectable		 5d0yA-5drzH:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		5 GLY A 298
PHE A 137
THR A 138
TYR A 439
VAL A 432
 MPG  A 605 (-3.9A)
None
None
None
None
 1.11A 5d0yA-5f15A:
2.8		 5d0yA-5f15A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fre EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF02973
(Sialidase) 		5 LEU A 109
ASN A 122
TYR A  65
VAL A  37
HIS A  93
 None
None
SIA  A 201 (-4.0A)
None
SIA  A 201 ( 4.8A)
 1.41A 5d0yA-5freA:
undetectable		 5d0yA-5freA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		5 LEU A 224
SER A 191
ASN A 214
PHE A 245
THR A 210
 None
 1.43A 5d0yA-5g5nA:
undetectable		 5d0yA-5g5nA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		5 LEU A 224
SER A 191
ASN A 214
PHE A 245
THR A 246
 None
 1.36A 5d0yA-5g5nA:
undetectable		 5d0yA-5g5nA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggy IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 LEU A  64
GLY A 297
PHE A 164
THR A 162
VAL A  56
 None
 1.43A 5d0yA-5ggyA:
undetectable		 5d0yA-5ggyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0k UNCHARACTERIZED
PROTEIN

(Pedobacter
heparinus) 		PF16265
(DUF4918) 		5 GLY A  61
PHE A 130
THR A 131
TYR A 145
VAL A 154
 None
 1.17A 5d0yA-5h0kA:
undetectable		 5d0yA-5h0kA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqw PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		5 GLY A2428
SER A2464
PHE A2494
THR A2495
VAL A2258
 None
 1.27A 5d0yA-5hqwA:
undetectable		 5d0yA-5hqwA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 LEU A 351
GLY A 700
ASP A 366
ASN A 349
VAL A 393
 None
 1.28A 5d0yA-5i2tA:
undetectable		 5d0yA-5i2tA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i77 ENDO-BETA-1,
4-GLUCANASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		5 LEU A  84
GLY A  91
PHE A 136
THR A 133
TYR A 125
 None
 1.47A 5d0yA-5i77A:
undetectable		 5d0yA-5i77A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw PUTATIVE
ANGIOTENSINOGEN

(Lampetra
fluviatilis) 		PF00079
(Serpin) 		5 LEU A 194
GLY A 158
SER A 108
ASN A 173
VAL A 118
 None
 1.44A 5d0yA-5inwA:
undetectable		 5d0yA-5inwA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase)
PF00515
(TPR_1) 		5 LEU A   9
GLY A  59
ASP A  14
SER A 187
VAL A 170
 None
 1.24A 5d0yA-5jheA:
2.4		 5d0yA-5jheA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		5 GLN A 257
GLY A 221
PHE A 310
THR A 324
HIS A 192
 None
 1.39A 5d0yA-5jjpA:
undetectable		 5d0yA-5jjpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 5 GLN A 536
GLY A  35
SER A 161
PHE A 165
ASN A 534
 None
 1.34A 5d0yA-5kk5A:
2.2		 5d0yA-5kk5A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A  78
GLY A  84
ASN A  88
PHE A 486
VAL A 189
 None
 1.21A 5d0yA-5l6fA:
undetectable		 5d0yA-5l6fA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLN A 620
GLY A 618
ASP A 381
SER A 573
ASN A 575
 None
None
None
None
FAD  A 701 ( 3.6A)
 1.41A 5d0yA-5nccA:
undetectable		 5d0yA-5nccA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		5 LEU A   4
ASP A  21
PHE A  20
ASN A   2
VAL A  58
 None
 1.46A 5d0yA-5nckA:
undetectable		 5d0yA-5nckA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 5 LEU A 249
GLY A 256
ASN A 284
PHE A 343
THR A 344
 None
 1.36A 5d0yA-5nfgA:
undetectable		 5d0yA-5nfgA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASP A 258
THR A 304
ASN A 316
VAL A 311
HIS A 264
 None
None
None
None
AHR  A 901 (-3.9A)
 1.45A 5d0yA-5opjA:
undetectable		 5d0yA-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		5 LEU A1000
GLY A 861
ASP A 925
PHE A 992
VAL A 980
 None
MJ8  A1601 ( 4.7A)
None
None
None
 1.42A 5d0yA-5u89A:
undetectable		 5d0yA-5u89A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8c TRANSCRIPTIONAL
REGULATOR

(Actinomyces
oris) 		no annotation 5 LEU A 240
GLY A 221
PHE A 197
THR A 199
VAL A 273
 None
 1.42A 5d0yA-5v8cA:
undetectable		 5d0yA-5v8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 GLY B 645
ASP B 511
SER B 513
THR B 639
TYR B 673
 None
 1.36A 5d0yA-5vniB:
undetectable		 5d0yA-5vniB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ

(Mycobacterium
tuberculosis) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
PF12680
(SnoaL_2) 		5 GLY A 250
ASP A  88
THR A  90
VAL A  96
HIS A 171
 None
 1.39A 5d0yA-5xe7A:
undetectable		 5d0yA-5xe7A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE

(Thermus
thermophilus) 		PF01546
(Peptidase_M20) 		5 LEU A 306
SER A 322
THR A 298
TYR A 269
ASN A 304
 None
 1.19A 5d0yA-5xoyA:
undetectable		 5d0yA-5xoyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 5 SER A 674
PHE A 930
THR A 924
VAL A 810
HIS A 917
 None
 1.26A 5d0yA-6bfuA:
undetectable		 5d0yA-6bfuA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		5 GLN G 178
GLY G 151
THR F 187
TYR G 129
VAL F 138
 None
 1.11A 5d0yA-6cnkG:
undetectable		 5d0yA-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3i -

(-) 		no annotation 5 LEU A  83
GLY A 107
PHE A 171
THR A 168
HIS A 270
 None
AKG  A 302 (-3.1A)
None
None
CO  A 301 (-3.2A)
 1.36A 5d0yA-6d3iA:
undetectable		 5d0yA-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL

(Escherichia
coli) 		PF00072
(Response_reg)
PF00196
(GerE) 		3 ARG A 151
LYS A 201
GLU A 205
 None
 0.77A 5d0yA-1a04A:
0.0		 5d0yA-1a04A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci0 PROTEIN (PNP
OXIDASE)

(Saccharomyces
cerevisiae) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 ARG A 117
LYS A  41
GLU A  45
 None
 0.53A 5d0yA-1ci0A:
0.0		 5d0yA-1ci0A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cz3 DIHYDROFOLATE
REDUCTASE

(Thermotoga
maritima) 		PF00186
(DHFR_1) 		3 ARG A 149
LYS A 160
GLU A 147
 None
 0.82A 5d0yA-1cz3A:
undetectable		 5d0yA-1cz3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		3 ARG A 556
LYS A 551
GLU A 555
 ATP  A 602 (-4.0A)
None
None
 0.80A 5d0yA-1gz4A:
0.0		 5d0yA-1gz4A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		3 ARG A  42
LYS A  88
GLU A  91
 None
 0.82A 5d0yA-1ij5A:
0.0		 5d0yA-1ij5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq6 (R)-SPECIFIC
ENOYL-COA HYDRATASE

(Aeromonas
caviae) 		PF01575
(MaoC_dehydratas) 		3 ARG A  12
LYS A  10
GLU A  96
 None
 0.68A 5d0yA-1iq6A:
undetectable		 5d0yA-1iq6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		3 ARG A 244
LYS A 238
GLU A 240
 None
 0.76A 5d0yA-1jeqA:
0.1		 5d0yA-1jeqA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onk GALACTOSE SPECIFIC
LECTIN I B CHAIN

(Viscum album) 		PF00652
(Ricin_B_lectin) 		3 ARG B  54
LYS B  53
GLU B   9
 None
 0.72A 5d0yA-1onkB:
undetectable		 5d0yA-1onkB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		3 ARG A 123
LYS A 117
GLU A 121
 GOL  A1902 (-4.1A)
None
GOL  A1902 (-3.3A)
 0.74A 5d0yA-1uarA:
undetectable		 5d0yA-1uarA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		3 ARG A 152
LYS A 125
GLU A 104
 None
 0.83A 5d0yA-1v2dA:
0.0		 5d0yA-1v2dA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 ARG A  58
LYS A 248
GLU A 252
 None
 0.77A 5d0yA-1vdkA:
1.7		 5d0yA-1vdkA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		3 ARG A 127
LYS A 120
GLU A 123
 None
 0.69A 5d0yA-1wy0A:
2.7		 5d0yA-1wy0A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5l EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF00041
(fn3) 		3 ARG A  86
LYS A  62
GLU A  45
 None
 0.75A 5d0yA-1x5lA:
undetectable		 5d0yA-1x5lA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ARG A 288
LYS A 132
GLU A 118
 None
 0.72A 5d0yA-1xdiA:
undetectable		 5d0yA-1xdiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE

(Enterococcus
faecalis) 		PF01515
(PTA_PTB) 		3 ARG A 267
LYS A  20
GLU A  24
 None
 0.78A 5d0yA-1ycoA:
undetectable		 5d0yA-1ycoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		3 ARG A 136
LYS A   7
GLU A  11
 None
 0.82A 5d0yA-1yggA:
undetectable		 5d0yA-1yggA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		3 ARG A  94
LYS A 117
GLU A  67
 None
 0.75A 5d0yA-1zzgA:
undetectable		 5d0yA-1zzgA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a90 DELTEX PROTEIN

(Drosophila
melanogaster) 		PF02825
(WWE) 		3 ARG A 200
LYS A 132
GLU A 134
 None
 0.73A 5d0yA-2a90A:
undetectable		 5d0yA-2a90A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2agm POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind)
PF08548
(Peptidase_M10_C) 		3 ARG A  62
LYS A 114
GLU A 126
 None
 0.75A 5d0yA-2agmA:
undetectable		 5d0yA-2agmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		3 ARG A  12
LYS A  60
GLU A  64
 None
 0.81A 5d0yA-2cyaA:
undetectable		 5d0yA-2cyaA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		3 ARG A 356
LYS A 349
GLU A 352
 None
 0.74A 5d0yA-2dhtA:
undetectable		 5d0yA-2dhtA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 ARG A 175
LYS A 153
GLU A 157
 None
 0.79A 5d0yA-2e1bA:
undetectable		 5d0yA-2e1bA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF14681
(UPRTase) 		3 ARG A  27
LYS A  26
GLU A  30
 None
 0.76A 5d0yA-2ehjA:
undetectable		 5d0yA-2ehjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		3 ARG A 181
LYS A 175
GLU A 179
 None
 0.79A 5d0yA-2ffhA:
3.0		 5d0yA-2ffhA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 ARG A  58
LYS A  51
GLU A  54
 None
 0.79A 5d0yA-2i4nA:
undetectable		 5d0yA-2i4nA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jya UNCHARACTERIZED
PROTEIN ATU1810

(Agrobacterium
fabrum) 		PF04800
(ETC_C1_NDUFA4) 		3 ARG A   7
LYS A  78
GLU A  79
 None
 0.72A 5d0yA-2jyaA:
undetectable		 5d0yA-2jyaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k6b PROGRAMMED CELL
DEATH PROTEIN 5

(Homo sapiens) 		PF01984
(dsDNA_bind) 		3 ARG A  40
LYS A  33
GLU A  36
 None
 0.78A 5d0yA-2k6bA:
undetectable		 5d0yA-2k6bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Bacteroides sp.
4_3_47FAA) 		PF00578
(AhpC-TSA) 		3 ARG A  45
LYS A  79
GLU A  83
 None
 0.82A 5d0yA-2lrnA:
undetectable		 5d0yA-2lrnA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2muy ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Escherichia
coli) 		PF06480
(FtsH_ext) 		3 ARG A  47
LYS A  87
GLU A  48
 None
 0.69A 5d0yA-2muyA:
undetectable		 5d0yA-2muyA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 ARG A 255
LYS A 291
GLU A 273
 None
 0.63A 5d0yA-2oi6A:
undetectable		 5d0yA-2oi6A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppq HOMOSERINE KINASE

(Agrobacterium
fabrum) 		PF01636
(APH) 		3 ARG A 119
LYS A 245
GLU A 249
 None
 0.80A 5d0yA-2ppqA:
undetectable		 5d0yA-2ppqA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		3 ARG A 221
LYS A 218
GLU A 219
 None
 0.74A 5d0yA-2qmiA:
undetectable		 5d0yA-2qmiA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv8 GENERAL SECRETION
PATHWAY PROTEIN H

(Vibrio cholerae) 		PF12019
(GspH) 		3 ARG A  60
LYS A  81
GLU A 136
 None
 0.80A 5d0yA-2qv8A:
undetectable		 5d0yA-2qv8A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vad RED FLUORESCENT
PROTEIN

(Discosoma sp.) 		PF01353
(GFP) 		3 ARG A  17
LYS A  50
GLU A  28
 None
 0.70A 5d0yA-2vadA:
undetectable		 5d0yA-2vadA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnx GLYCOSIDE HYDROLASE,
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		3 ARG A  51
LYS A  49
GLU A  95
 None
 0.78A 5d0yA-2wnxA:
undetectable		 5d0yA-2wnxA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 ARG A 182
LYS A 175
GLU A 178
 None
 0.70A 5d0yA-2wrtA:
undetectable		 5d0yA-2wrtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE

(Streptococcus
pneumoniae) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		3 ARG A 299
LYS A 308
GLU A 276
 None
 0.78A 5d0yA-2wwdA:
undetectable		 5d0yA-2wwdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfa ACTIN
DEPOLYMERIZATION
FACTOR 2

(Plasmodium
berghei) 		PF00241
(Cofilin_ADF) 		3 ARG A  68
LYS A  63
GLU A  66
 None
 0.76A 5d0yA-2xfaA:
undetectable		 5d0yA-2xfaA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		3 ARG A 193
LYS A 291
GLU A 293
 None
 0.60A 5d0yA-2z6iA:
undetectable		 5d0yA-2z6iA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 ARG B 441
LYS B 415
GLU B 414
 None
 0.73A 5d0yA-2z7xB:
undetectable		 5d0yA-2z7xB:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 ARG A1139
LYS A1127
GLU A1129
 None
 0.66A 5d0yA-2zxqA:
undetectable		 5d0yA-2zxqA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF03480
(DctP) 		3 ARG A  33
LYS A  60
GLU A  68
 None
 0.76A 5d0yA-2zzwA:
undetectable		 5d0yA-2zzwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db1 STS-2 PROTEIN

(Mus musculus) 		PF00300
(His_Phos_1) 		3 ARG A 425
LYS A 454
GLU A 458
 None
 0.66A 5d0yA-3db1A:
undetectable		 5d0yA-3db1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN

(Sulfolobus
solfataricus) 		PF00571
(CBS) 		3 ARG A 252
LYS A 140
GLU A 223
 None
 0.79A 5d0yA-3ddjA:
undetectable		 5d0yA-3ddjA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgt ENDO-1,3-BETA-GLUCAN
ASE

(Streptomyces
sioyaensis) 		PF00722
(Glyco_hydro_16) 		3 ARG A 101
LYS A  99
GLU A 196
 None
 0.83A 5d0yA-3dgtA:
undetectable		 5d0yA-3dgtA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlv SIGNAL RECOGNITION
PARTICLE 19 KDA
PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 ARG B  98
LYS B  91
GLU B  94
 None
 0.70A 5d0yA-3dlvB:
undetectable		 5d0yA-3dlvB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		3 ARG A 125
LYS A 186
GLU A 190
 None
 0.74A 5d0yA-3eu8A:
undetectable		 5d0yA-3eu8A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		3 ARG A 406
LYS A 451
GLU A 455
 None
 0.80A 5d0yA-3gitA:
undetectable		 5d0yA-3gitA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc7 GENE 12 PROTEIN

(Mycobacterium
virus D29) 		PF01083
(Cutinase) 		3 ARG A 159
LYS A 112
GLU A 157
 None
 0.77A 5d0yA-3hc7A:
undetectable		 5d0yA-3hc7A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw 50S RIBOSOMAL
PROTEIN L7AE

(Pyrococcus
furiosus) 		PF01248
(Ribosomal_L7Ae) 		3 ARG C  34
LYS C  35
GLU C  39
 G  D  24 ( 3.1A)
A  D  25 ( 2.7A)
G  D  31 ( 3.7A)
 0.76A 5d0yA-3hjwC:
undetectable		 5d0yA-3hjwC:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkf IGH PROTEIN

(Mus musculus) 		PF07654
(C1-set) 		3 ARG A 325
LYS A 323
GLU A 336
 None
 0.73A 5d0yA-3hkfA:
undetectable		 5d0yA-3hkfA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		3 ARG M 406
LYS M 451
GLU M 455
 None
 0.81A 5d0yA-3i04M:
undetectable		 5d0yA-3i04M:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		3 ARG A 286
LYS A 253
GLU A 252
 None
 0.77A 5d0yA-3jurA:
undetectable		 5d0yA-3jurA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmd CGMP DEPENDENT
PROTEIN KINASE

(Homo sapiens) 		no annotation 3 ARG A  21
LYS A  14
GLU A  17
 None
 0.59A 5d0yA-3nmdA:
undetectable		 5d0yA-3nmdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrk LIC12922

(Leptospira
interrogans) 		PF13145
(Rotamase_2)
PF13624
(SurA_N_3) 		3 ARG A 200
LYS A 297
GLU A 299
 None
 0.67A 5d0yA-3nrkA:
undetectable		 5d0yA-3nrkA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		3 ARG A 133
LYS A 161
GLU A 123
 None
 0.75A 5d0yA-3ooiA:
undetectable		 5d0yA-3ooiA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		3 ARG X 124
LYS X 117
GLU X 120
 None
 0.60A 5d0yA-3pb9X:
undetectable		 5d0yA-3pb9X:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sw0 COMPLEMENT FACTOR H

(Homo sapiens) 		PF00084
(Sushi) 		3 ARG X1149
LYS X1148
GLU X1135
 None
 0.79A 5d0yA-3sw0X:
undetectable		 5d0yA-3sw0X:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A

(Arabidopsis
thaliana) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		3 ARG A 167
LYS A 160
GLU A 163
 None
 0.63A 5d0yA-3t34A:
undetectable		 5d0yA-3t34A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 ARG A 464
LYS A 429
GLU A 433
 None
 0.69A 5d0yA-3zzuA:
undetectable		 5d0yA-3zzuA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC

(Leishmania
major) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 ARG A 111
LYS A 115
GLU A  82
 None
 0.83A 5d0yA-4a26A:
undetectable		 5d0yA-4a26A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		3 ARG A 582
LYS A 575
GLU A 578
 None
 0.58A 5d0yA-4az7A:
undetectable		 5d0yA-4az7A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bof ARGININE DEIMINASE

(Streptococcus
pyogenes) 		PF02274
(Amidinotransf) 		3 ARG A 299
LYS A 316
GLU A 314
 None
 0.78A 5d0yA-4bofA:
undetectable		 5d0yA-4bofA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g88 OUTER MEMBRANE
PROTEIN OMP38

(Acinetobacter
baumannii) 		PF00691
(OmpA) 		3 ARG A 339
LYS A 255
GLU A 258
 None
 0.64A 5d0yA-4g88A:
undetectable		 5d0yA-4g88A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgh CULLIN-5

(Homo sapiens) 		PF00888
(Cullin) 		3 ARG D 244
LYS D 237
GLU D 240
 None
 0.77A 5d0yA-4jghD:
undetectable		 5d0yA-4jghD:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		3 ARG A 133
LYS A 130
GLU A 124
 None
 0.67A 5d0yA-4n7tA:
undetectable		 5d0yA-4n7tA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9f CULLIN-5

(Homo sapiens) 		no annotation 3 ARG U 244
LYS U 237
GLU U 240
 None
 0.78A 5d0yA-4n9fU:
undetectable		 5d0yA-4n9fU:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqi SH3
DOMAIN-CONTAINING
PROTEIN

(Dictyostelium
discoideum) 		PF08397
(IMD) 		3 ARG A  86
LYS A 196
GLU A 199
 None
 0.66A 5d0yA-4nqiA:
3.5		 5d0yA-4nqiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		3 ARG A 479
LYS A 477
GLU A 486
 None
 0.65A 5d0yA-4phcA:
0.4		 5d0yA-4phcA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		3 ARG A  52
LYS A  56
GLU A  21
 None
 0.75A 5d0yA-4q8lA:
undetectable		 5d0yA-4q8lA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rj9 C2 DOMAIN-CONTAINING
PROTEIN-LIKE

(Oryza sativa) 		PF00168
(C2) 		3 ARG A  12
LYS A  10
GLU A  56
 None
 0.75A 5d0yA-4rj9A:
undetectable		 5d0yA-4rj9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2

(Homo sapiens) 		PF06470
(SMC_hinge) 		3 ARG A 566
LYS A 561
GLU A 565
 None
 0.73A 5d0yA-4u4pA:
undetectable		 5d0yA-4u4pA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8s RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00161
(RIP) 		3 ARG A  22
LYS A  15
GLU A 168
 None
 0.65A 5d0yA-4z8sA:
undetectable		 5d0yA-4z8sA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgs PUTATIVE D-LACTATE
DEHYDROGENASE

(Chlamydomonas
reinhardtii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ARG A 127
LYS A 369
GLU A 367
 None
 0.80A 5d0yA-4zgsA:
undetectable		 5d0yA-4zgsA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		3 ARG A  42
LYS A 105
GLU A 109
 None
 0.70A 5d0yA-4zwnA:
undetectable		 5d0yA-4zwnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		3 ARG C 789
LYS C 782
GLU C 785
 None
 0.83A 5d0yA-5a5tC:
undetectable		 5d0yA-5a5tC:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5auo ATPASE INVOLVED IN
CHROMOSOME
PARTITIONING,
PARA/MIND FAMILY,
MRP HOMOLOG

(Thermococcus
kodakarensis) 		PF10609
(ParA) 		3 ARG B 247
LYS B 240
GLU B 243
 None
 0.73A 5d0yA-5auoB:
undetectable		 5d0yA-5auoB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4s CONTACTIN-4

(Mus musculus) 		PF00041
(fn3) 		3 ARG A 854
LYS A 852
GLU A 837
 None
 0.78A 5d0yA-5e4sA:
undetectable		 5d0yA-5e4sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e55 CONTACTIN-6

(Mus musculus) 		PF00041
(fn3) 		3 ARG A 856
LYS A 854
GLU A 839
 None
 0.82A 5d0yA-5e55A:
undetectable		 5d0yA-5e55A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		3 ARG A 986
LYS A 976
GLU A 984
 None
 0.65A 5d0yA-5gjvA:
undetectable		 5d0yA-5gjvA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 3 ARG C  23
LYS C  72
GLU C  76
 None
 0.57A 5d0yA-5h9uC:
undetectable		 5d0yA-5h9uC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		3 ARG A 745
LYS A 452
GLU A 456
 None
 0.82A 5d0yA-5hlbA:
undetectable		 5d0yA-5hlbA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Homo sapiens) 		PF00061
(Lipocalin) 		3 ARG A  10
LYS A  55
GLU A  57
 None
 0.81A 5d0yA-5hz5A:
undetectable		 5d0yA-5hz5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ARG A 877
LYS A 910
GLU A 913
 None
 0.59A 5d0yA-5j6sA:
undetectable		 5d0yA-5j6sA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		3 ARG A 191
LYS A 214
GLU A 218
 None
 0.76A 5d0yA-5nvrA:
undetectable		 5d0yA-5nvrA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3p MEMBRANE-ASSOCIATED
PROTEIN SLR1513

(Synechocystis
sp. PCC 6803) 		no annotation 3 ARG A  78
LYS A  22
GLU A  26
 None
 0.77A 5d0yA-5o3pA:
undetectable		 5d0yA-5o3pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		3 ARG A 651
LYS A 644
GLU A 647
 None
 0.76A 5d0yA-5odrA:
undetectable		 5d0yA-5odrA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ARG A 225
LYS A 276
GLU A 278
 None
 0.78A 5d0yA-5t9gA:
undetectable		 5d0yA-5t9gA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u22 N2152

(Neocallimastix
frontalis) 		PF01229
(Glyco_hydro_39) 		3 ARG A 425
LYS A 380
GLU A 382
 None
 0.80A 5d0yA-5u22A:
undetectable		 5d0yA-5u22A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ARG D 670
LYS D 632
GLU D 591
 None
 0.75A 5d0yA-5uheD:
2.6		 5d0yA-5uheD:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		3 ARG A 219
LYS A 210
GLU A 214
 None
 0.76A 5d0yA-5volA:
undetectable		 5d0yA-5volA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x89 ENDA-LIKE
PROTEIN,TRNA-SPLICIN
G ENDONUCLEASE

(Methanopyrus
kandleri) 		no annotation 3 ARG A  72
LYS A  16
GLU A  65
 None
 0.81A 5d0yA-5x89A:
undetectable		 5d0yA-5x89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
yayanosii) 		PF02463
(SMC_N) 		3 ARG A 105
LYS A 103
GLU A  81
 None
 0.81A 5d0yA-5xeiA:
undetectable		 5d0yA-5xeiA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyb -

(-) 		no annotation 3 ARG A 138
LYS A 120
GLU A 124
 None
 0.80A 5d0yA-5xybA:
undetectable		 5d0yA-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk7 MAINTENANCE OF
MITOCHONDRIAL
MORPHOLOGY PROTEIN 1

(Zygosaccharomyces
rouxii) 		no annotation 3 ARG A 415
LYS A 410
GLU A 414
 PO4  A 502 (-3.3A)
None
None
 0.64A 5d0yA-5yk7A:
undetectable		 5d0yA-5yk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 3 ARG A 306
LYS A 313
GLU A 315
 None
 0.80A 5d0yA-5yp3A:
undetectable		 5d0yA-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 3 ARG A 986
LYS A 976
GLU A 984
 None
 0.77A 5d0yA-6byoA:
undetectable		 5d0yA-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c49 ALCOHOL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 3 ARG A 130
LYS A 128
GLU A  34
 None
 0.76A 5d0yA-6c49A:
undetectable		 5d0yA-6c49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 3 ARG A1187
LYS A1215
GLU A1177
 None
 0.83A 5d0yA-6cenA:
undetectable		 5d0yA-6cenA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f76 -

(-) 		no annotation 3 ARG B  41
LYS B   5
GLU B   3
 CVK  B 203 (-3.6A)
CVK  B 203 (-3.8A)
CVK  B 203 ( 4.8A)
 0.79A 5d0yA-6f76B:
undetectable		 5d0yA-6f76B:
undetectable