SIMILAR PATTERNS OF AMINO ACIDS FOR 5D0X_Y_BO2Y301_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e9y | UREASE SUBUNIT BETA (Helicobacterpylori) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | THR B 272ALA B 298GLY B 281GLY B 280ASP B 362 | NoneNoneNoneNoneHAE B 800 ( 2.5A) | 0.99A | 5d0xY-1e9yB:undetectable5d0xZ-1e9yB:undetectable | 5d0xY-1e9yB:17.525d0xZ-1e9yB:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gk2 | HISTIDINEAMMONIA-LYASE (Pseudomonasputida) |
PF00221(Lyase_aromatic) | 5 | SER A 139ALA A 199ALA A 202GLY A 144GLY A 196 | None | 1.08A | 5d0xY-1gk2A:undetectable5d0xZ-1gk2A:undetectable | 5d0xY-1gk2A:18.155d0xZ-1gk2A:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpe | PROTEIN (GLUCOSEOXIDASE) (Penicilliumamagasakiense) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | THR A 35ALA A 572GLY A 106GLY A 105ALA A 232 | FAD A 600 (-2.8A)NoneFAD A 600 (-3.0A)NoneNone | 1.08A | 5d0xY-1gpeA:undetectable5d0xZ-1gpeA:undetectable | 5d0xY-1gpeA:16.525d0xZ-1gpeA:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ib1 | 14-3-3 ZETA ISOFORM (Homo sapiens) |
PF00244(14-3-3) | 5 | SER A 156ALA A 152ALA A 148GLY A 169ASP A 124 | None | 0.94A | 5d0xY-1ib1A:undetectable5d0xZ-1ib1A:undetectable | 5d0xY-1ib1A:22.765d0xZ-1ib1A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2q | PROTEASOME BETASUBUNIT (Archaeoglobusfulgidus) |
PF00227(Proteasome) | 5 | ALA H 20THR H 21ALA H 27LYS H 33GLY H 47 | CIB H1001 (-3.8A)CIB H1001 (-4.5A)CIB H1001 (-3.5A)CIB H1001 (-4.0A)CIB H1001 (-4.4A) | 0.24A | 5d0xY-1j2qH:16.65d0xZ-1j2qH:24.6 | 5d0xY-1j2qH:29.915d0xZ-1j2qH:26.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2q | PROTEASOME BETASUBUNIT (Archaeoglobusfulgidus) |
PF00227(Proteasome) | 5 | ALA H 20THR H 21ALA H 27LYS H 33GLY H 47 | CIB H1001 (-3.8A)CIB H1001 (-4.5A)CIB H1001 (-3.5A)CIB H1001 (-4.0A)CIB H1001 (-4.4A) | 0.76A | 5d0xY-1j2qH:16.65d0xZ-1j2qH:24.6 | 5d0xY-1j2qH:29.915d0xZ-1j2qH:26.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n2f | ORGANICHYDROPEROXIDERESISTANCE PROTEIN (Pseudomonasaeruginosa) |
PF02566(OsmC) | 5 | ALA A 22THR A 13ALA A 12GLY A 16GLY A 17 | None | 1.03A | 5d0xY-1n2fA:undetectable5d0xZ-1n2fA:undetectable | 5d0xY-1n2fA:23.085d0xZ-1n2fA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nb2 | NUCLEOSIDEDIPHOSPHATE KINASE (Virgibacillushalodenitrificans) |
PF00334(NDK) | 5 | ALA A 85THR A 84ALA A 82GLY A 90ASP A 119 | None | 1.03A | 5d0xY-1nb2A:undetectable5d0xZ-1nb2A:undetectable | 5d0xY-1nb2A:22.695d0xZ-1nb2A:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5q | PROTEASOME BETA-TYPESUBUNIT 1 (Rhodococcuserythropolis) |
PF00227(Proteasome) | 5 | ALA H 20THR H 21ALA H 27LYS H 33GLY H 47 | None | 0.67A | 5d0xY-1q5qH:14.95d0xZ-1q5qH:22.3 | 5d0xY-1q5qH:27.505d0xZ-1q5qH:24.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5q | PROTEASOME BETA-TYPESUBUNIT 1 (Rhodococcuserythropolis) |
PF00227(Proteasome) | 6 | ALA H 20THR H 21ALA H 27LYS H 33GLY H 47ALA H 49 | None | 0.39A | 5d0xY-1q5qH:14.95d0xZ-1q5qH:22.3 | 5d0xY-1q5qH:27.505d0xZ-1q5qH:24.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5r | PROTEASOME BETA-TYPESUBUNIT 1 (Rhodococcuserythropolis) |
PF00227(Proteasome) | 5 | ALA H 20THR H 21ALA H 27GLY H 47ALA H 49 | None | 0.51A | 5d0xY-1q5rH:13.55d0xZ-1q5rH:22.1 | 5d0xY-1q5rH:23.235d0xZ-1q5rH:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qnt | METHYLATED-DNA--PROTEIN-CYSTEINEMETHYLTRANSFERASE (Homo sapiens) |
PF01035(DNA_binding_1)PF02870(Methyltransf_1N) | 5 | ALA A 118ALA A 121GLY A 131GLY A 132ALA A 129 | None | 1.06A | 5d0xY-1qntA:undetectable5d0xZ-1qntA:undetectable | 5d0xY-1qntA:22.945d0xZ-1qntA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rc2 | AQUAPORIN Z (Escherichiacoli) |
no annotation | 5 | ALA B 162ALA B 165GLY B 59GLY B 60ALA B 51 | None | 1.07A | 5d0xY-1rc2B:undetectable5d0xZ-1rc2B:undetectable | 5d0xY-1rc2B:25.005d0xZ-1rc2B:24.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rhy | IMIDAZOLE GLYCEROLPHOSPHATEDEHYDRATASE (Cryptococcusneoformans) |
PF00475(IGPD) | 5 | ALA A 49THR A 48GLY A 55GLY A 54ALA A 178 | None | 1.06A | 5d0xY-1rhyA:undetectable5d0xZ-1rhyA:undetectable | 5d0xY-1rhyA:21.365d0xZ-1rhyA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7g | PROBABLE AMMONIUMTRANSPORTER (Escherichiacoli) |
PF00909(Ammonium_transp) | 5 | ALA A 240ALA A 241GLY A 282GLY A 283ALA A 284 | None | 1.07A | 5d0xY-1u7gA:undetectable5d0xZ-1u7gA:undetectable | 5d0xY-1u7gA:20.905d0xZ-1u7gA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v6u | ENDO-1,4-BETA-D-XYLANASE (Streptomycesolivaceoviridis) |
PF00331(Glyco_hydro_10)PF00652(Ricin_B_lectin) | 5 | ALA A 295THR A 294GLY A 303GLY A 302ALA A 299 | None | 1.07A | 5d0xY-1v6uA:undetectable5d0xZ-1v6uA:undetectable | 5d0xY-1v6uA:20.515d0xZ-1v6uA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zj9 | PROBABLEFERREDOXIN-DEPENDENTNITRITE REDUCTASENIRA (Mycobacteriumtuberculosis) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | ALA A 226THR A 210ALA A 211GLY A 244ALA A 254 | None | 1.00A | 5d0xY-1zj9A:undetectable5d0xZ-1zj9A:undetectable | 5d0xY-1zj9A:17.915d0xZ-1zj9A:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c63 | 14-3-3 PROTEIN ETA (Homo sapiens) |
PF00244(14-3-3) | 5 | SER A 161ALA A 157ALA A 153GLY A 174ASP A 129 | None | 1.03A | 5d0xY-2c63A:undetectable5d0xZ-2c63A:undetectable | 5d0xY-2c63A:22.055d0xZ-2c63A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d2x | 2-DEOXY-SCYLLO-INOSOSE SYNTHASE (Bacilluscirculans) |
PF01761(DHQ_synthase) | 5 | SER A 136ALA A 133ALA A 164GLY A 104GLY A 103 | NoneNoneNoneGOL A 607 (-4.1A) CO A 603 (-3.1A) | 1.05A | 5d0xY-2d2xA:undetectable5d0xZ-2d2xA:undetectable | 5d0xY-2d2xA:18.705d0xZ-2d2xA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elc | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | ALA A 294ALA A 293GLY A 101GLY A 100ALA A 97 | None | 1.06A | 5d0xY-2elcA:undetectable5d0xZ-2elcA:undetectable | 5d0xY-2elcA:20.125d0xZ-2elcA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gs8 | MEVALONATEPYROPHOSPHATEDECARBOXYLASE (Streptococcuspyogenes) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | SER A 33ALA A 152ALA A 151GLY A 158ALA A 159 | None | 1.08A | 5d0xY-2gs8A:undetectable5d0xZ-2gs8A:undetectable | 5d0xY-2gs8A:20.315d0xZ-2gs8A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2id3 | PUTATIVETRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N)PF16859(TetR_C_11) | 5 | ALA A 27ALA A 30GLY A 64GLY A 63ALA A 66 | None | 1.09A | 5d0xY-2id3A:undetectable5d0xZ-2id3A:undetectable | 5d0xY-2id3A:19.825d0xZ-2id3A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iun | AVIAN ADENOVIRUSCELO LONG FIBRE (Fowlaviadenovirus A) |
PF16812(AdHead_fibreRBD) | 5 | ALA A 586THR A 587ALA A 620GLY A 679ALA A 680 | None | 1.07A | 5d0xY-2iunA:undetectable5d0xZ-2iunA:undetectable | 5d0xY-2iunA:23.145d0xZ-2iunA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pne | 6.5 KDA GLYCINE-RICHANTIFREEZE PROTEIN (Hypogastruraharveyi) |
no annotation | 5 | ALA A 20ALA A 19GLY A 79GLY A 61ASP A 5 | None | 1.02A | 5d0xY-2pneA:undetectable5d0xZ-2pneA:undetectable | 5d0xY-2pneA:17.925d0xZ-2pneA:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2puz | IMIDAZOLONEPROPIONASE (Agrobacteriumfabrum) |
PF01979(Amidohydro_1) | 5 | ALA A 290ALA A 294GLY A 264GLY A 265ALA A 266 | None | 1.09A | 5d0xY-2puzA:undetectable5d0xZ-2puzA:undetectable | 5d0xY-2puzA:19.765d0xZ-2puzA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r6h | NADH:UBIQUINONEOXIDOREDUCTASE, NATRANSLOCATING, FSUBUNIT (Porphyromonasgingivalis) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | ALA A 291ALA A 214GLY A 286GLY A 287ALA A 288 | FAD A 1 ( 3.9A)NoneNoneNoneFAD A 1 ( 3.7A) | 0.86A | 5d0xY-2r6hA:undetectable5d0xZ-2r6hA:undetectable | 5d0xY-2r6hA:20.685d0xZ-2r6hA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rqw | BUD EMERGENCEPROTEIN 1 (Saccharomycescerevisiae) |
PF00018(SH3_1) | 5 | THR A 175ALA A 168GLY A 202GLY A 203ASP A 172 | None | 0.95A | 5d0xY-2rqwA:undetectable5d0xZ-2rqwA:undetectable | 5d0xY-2rqwA:20.375d0xZ-2rqwA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w2g | NON-STRUCTURALPROTEIN 3 (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF11633(SUD-M) | 5 | SER A 626ALA A 590GLY A 491GLY A 494ALA A 493 | None | 0.94A | 5d0xY-2w2gA:undetectable5d0xZ-2w2gA:undetectable | 5d0xY-2w2gA:21.825d0xZ-2w2gA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yrr | AMINOTRANSFERASE,CLASS V (Thermusthermophilus) |
PF00266(Aminotran_5) | 6 | SER A 184ALA A 56ALA A 55GLY A 193GLY A 59ALA A 58 | None | 1.47A | 5d0xY-2yrrA:undetectable5d0xZ-2yrrA:undetectable | 5d0xY-2yrrA:19.025d0xZ-2yrrA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z22 | PERIPLASMICPHOSPHATE-BINDINGPROTEIN (Yersinia pestis) |
no annotation | 5 | THR X 10ALA X 13GLY X 40GLY X 41ALA X 7 | PO4 X2322 (-2.9A)NoneNoneNoneNone | 1.08A | 5d0xY-2z22X:undetectable5d0xZ-2z22X:undetectable | 5d0xY-2z22X:22.605d0xZ-2z22X:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aar | ECTONUCLEOSIDETRIPHOSPHATEDIPHOSPHOHYDROLASE I (Legionellapneumophila) |
PF01150(GDA1_CD39) | 5 | SER A 55ALA A 117THR A 118GLY A 84ALA A 86 | None | 0.92A | 5d0xY-3aarA:undetectable5d0xZ-3aarA:undetectable | 5d0xY-3aarA:20.695d0xZ-3aarA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bog | 6.5 KDA GLYCINE-RICHANTIFREEZE PROTEIN (Hypogastruraharveyi) |
no annotation | 5 | ALA A 20ALA A 19GLY A 79GLY A 61ASP A 5 | None | 1.04A | 5d0xY-3bogA:undetectable5d0xZ-3bogA:undetectable | 5d0xY-3bogA:17.455d0xZ-3bogA:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3faj | PUTATIVEUNCHARACTERIZEDPROTEIN (Acidianustwo-tailedvirus) |
no annotation | 5 | ALA A 43ALA A 46GLY A 14GLY A 13ALA A 12 | None | 0.97A | 5d0xY-3fajA:undetectable5d0xZ-3fajA:undetectable | 5d0xY-3fajA:23.045d0xZ-3fajA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fj1 | PUTATIVEPHOSPHOSUGARISOMERASE (Ruegeriapomeroyi) |
PF01380(SIS) | 5 | SER A 239ALA A 273ALA A 293GLY A 211ALA A 260 | None | 1.02A | 5d0xY-3fj1A:undetectable5d0xZ-3fj1A:undetectable | 5d0xY-3fj1A:22.255d0xZ-3fj1A:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3grz | RIBOSOMAL PROTEINL11METHYLTRANSFERASE (Lactobacillusdelbrueckii) |
PF06325(PrmA) | 5 | SER A 211ALA A 215ALA A 219GLY A 184ALA A 204 | NoneNoneNoneGOL A 322 ( 3.7A)None | 1.09A | 5d0xY-3grzA:undetectable5d0xZ-3grzA:undetectable | 5d0xY-3grzA:23.405d0xZ-3grzA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn7 | UDP-N-ACETYLMURAMATE-L-ALANINE LIGASE (Psychrobacterarcticus) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | ALA A 345THR A 344ALA A 348GLY A 339ALA A 335 | None | 1.05A | 5d0xY-3hn7A:undetectable5d0xZ-3hn7A:undetectable | 5d0xY-3hn7A:17.435d0xZ-3hn7A:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iau | THREONINE DEAMINASE (Solanumlycopersicum) |
PF00291(PALP) | 5 | ALA A 126ALA A 95GLY A 154GLY A 155ALA A 134 | NoneLLP A 91 ( 3.6A)NoneNoneNone | 0.90A | 5d0xY-3iauA:undetectable5d0xZ-3iauA:undetectable | 5d0xY-3iauA:20.775d0xZ-3iauA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ifr | CARBOHYDRATE KINASE,FGGY (Rhodospirillumrubrum) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ALA A 441ALA A 438GLY A 241GLY A 242ALA A 243 | None | 1.01A | 5d0xY-3ifrA:undetectable5d0xZ-3ifrA:undetectable | 5d0xY-3ifrA:18.155d0xZ-3ifrA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jru | PROBABLE CYTOSOLAMINOPEPTIDASE (Xanthomonasoryzae) |
no annotation | 5 | ALA B 202THR B 201ALA B 199GLY B 207ALA B 206 | None | 1.09A | 5d0xY-3jruB:undetectable5d0xZ-3jruB:undetectable | 5d0xY-3jruB:19.085d0xZ-3jruB:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lki | FRUCTOKINASE (Xylellafastidiosa) |
PF00294(PfkB) | 5 | ALA A 99THR A 98ALA A 120GLY A 44GLY A 45 | None | 0.78A | 5d0xY-3lkiA:undetectable5d0xZ-3lkiA:undetectable | 5d0xY-3lkiA:20.115d0xZ-3lkiA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1u | PUTATIVEGAMMA-D-GLUTAMYL-L-DIAMINO ACIDENDOPEPTIDASE (Desulfovibriovulgaris) |
PF00877(NLPC_P60)PF12912(N_NLPC_P60)PF12913(SH3_6)PF12914(SH3_7) | 5 | SER A 335ALA A 185THR A 184ALA A 155GLY A 323 | GOL A 3 (-4.0A)GOL A 3 (-4.1A)GOL A 3 (-4.0A)NoneNone | 0.75A | 5d0xY-3m1uA:undetectable5d0xZ-3m1uA:undetectable | 5d0xY-3m1uA:18.315d0xZ-3m1uA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mg6 | PROTEASOME COMPONENTPRE3 (Saccharomycescerevisiae) |
no annotation | 5 | THR N 21ALA N 27LYS N 33GLY N 47ALA N 49 | None | 0.59A | 5d0xY-3mg6N:16.75d0xZ-3mg6N:25.1 | 5d0xY-3mg6N:26.705d0xZ-3mg6N:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nwa | ENVELOPEGLYCOPROTEIN B (Humanalphaherpesvirus1) |
no annotation | 5 | ALA B 211THR B 221ALA B 222ALA B 190ASP B 188 | None | 0.94A | 5d0xY-3nwaB:undetectable5d0xZ-3nwaB:undetectable | 5d0xY-3nwaB:13.925d0xZ-3nwaB:15.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pk0 | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Mycolicibacteriumsmegmatis) |
PF13561(adh_short_C2) | 5 | ALA A 34ALA A 78GLY A 14GLY A 13ALA A 36 | None | 1.04A | 5d0xY-3pk0A:undetectable5d0xZ-3pk0A:undetectable | 5d0xY-3pk0A:22.105d0xZ-3pk0A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qd9 | QSOX FROMTRYPANOSOMA BRUCEI(TBQSOX) (Trypanosomabrucei) |
PF00085(Thioredoxin)PF04777(Evr1_Alr) | 5 | THR A 78ALA A 76GLY A 84ALA A 83ASP A 37 | None | 1.08A | 5d0xY-3qd9A:undetectable5d0xZ-3qd9A:undetectable | 5d0xY-3qd9A:18.995d0xZ-3qd9A:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r64 | NAD DEPENDENTBENZALDEHYDEDEHYDROGENASE (Corynebacteriumglutamicum) |
PF00171(Aldedh) | 5 | SER A 412ALA A 409ALA A 406GLY A 415ALA A 418 | SER A 412 ( 0.0A)ALA A 409 ( 0.0A)ALA A 406 ( 0.0A)GLY A 415 ( 0.0A)ALA A 418 ( 0.0A) | 0.96A | 5d0xY-3r64A:undetectable5d0xZ-3r64A:undetectable | 5d0xY-3r64A:17.265d0xZ-3r64A:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r9b | CYTOCHROME P450164A2 (Mycolicibacteriumsmegmatis) |
PF00067(p450) | 5 | ALA A 333ALA A 334GLY A 41GLY A 42ASP A 59 | None | 1.03A | 5d0xY-3r9bA:undetectable5d0xZ-3r9bA:undetectable | 5d0xY-3r9bA:20.835d0xZ-3r9bA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rij | SC_2CX5 (Thermusthermophilus) |
PF04073(tRNA_edit) | 5 | ALA A 87ALA A 91GLY A 56GLY A 59ALA A 60 | None | 0.99A | 5d0xY-3rijA:undetectable5d0xZ-3rijA:undetectable | 5d0xY-3rijA:24.425d0xZ-3rijA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6l | HEP_HAG FAMILY (Burkholderiapseudomallei) |
PF05658(YadA_head)PF05662(YadA_stalk) | 6 | ALA A 97THR A 103ALA A 88GLY A 106GLY A 92ALA A 95 | None | 1.44A | 5d0xY-3s6lA:undetectable5d0xZ-3s6lA:undetectable | 5d0xY-3s6lA:22.945d0xZ-3s6lA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 5 | ALA A 113THR A 112ALA A 133GLY A 58GLY A 59 | NoneNoneNoneADN A 353 (-3.3A)ADN A 353 (-3.2A) | 1.01A | 5d0xY-3uboA:undetectable5d0xZ-3uboA:undetectable | 5d0xY-3uboA:22.445d0xZ-3uboA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3unf | PROTEASOME SUBUNITBETA TYPE-10 (Mus musculus) |
PF00227(Proteasome)PF12465(Pr_beta_C) | 6 | ALA H 20THR H 21ALA H 27LYS H 33GLY H 47ALA H 49 | 04C H 301 (-3.9A)04C H 301 (-3.9A)None04C H 301 (-3.5A)04C H 301 (-3.7A)04C H 301 (-3.6A) | 0.55A | 5d0xY-3unfH:17.45d0xZ-3unfH:25.4 | 5d0xY-3unfH:25.745d0xZ-3unfH:25.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3whl | PROTEASOME-ACTIVATING NUCLEOTIDASE, 26SPROTEASE REGULATORYSUBUNIT 6A (Pyrococcusfuriosus;Saccharomycescerevisiae) |
PF00004(AAA) | 5 | ALA A 358ALA A 380GLY A 184GLY A 185ASP A 353 | ALA A 358 ( 0.0A)ALA A 380 ( 0.0A)GLY A 184 (-0.0A)GLY A 185 ( 0.0A)ASP A 353 ( 0.6A) | 1.03A | 5d0xY-3whlA:undetectable5d0xZ-3whlA:undetectable | 5d0xY-3whlA:20.595d0xZ-3whlA:22.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3wxr | PROTEASOME SUBUNITBETA TYPE-5 (Saccharomycescerevisiae) |
PF00227(Proteasome) | 7 | ALA L 20THR L 21ALA L 27LYS L 33GLY L 47GLY L 48ALA L 49 | None | 0.72A | 5d0xY-3wxrL:38.05d0xZ-3wxrL:23.0 | 5d0xY-3wxrL:75.445d0xZ-3wxrL:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c6o | CAD PROTEIN (Homo sapiens) |
PF01979(Amidohydro_1) | 5 | ALA A1490THR A1489GLY A1496GLY A1495ALA A1494 | None | 1.02A | 5d0xY-4c6oA:undetectable5d0xZ-4c6oA:undetectable | 5d0xY-4c6oA:20.635d0xZ-4c6oA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dhz | UBIQUITINTHIOESTERASEOTUBAIN-LIKE (Caenorhabditiselegans;Homo sapiens) |
PF10275(Peptidase_C65) | 5 | ALA A 64GLY A 242GLY A 243ALA A 239ASP A 235 | None | 1.03A | 5d0xY-4dhzA:undetectable5d0xZ-4dhzA:undetectable | 5d0xY-4dhzA:22.745d0xZ-4dhzA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dio | NAD(P)TRANSHYDROGENASESUBUNIT ALPHA PART 1 (Sinorhizobiummeliloti) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 5 | ALA A 97THR A 96ALA A 94GLY A 117ALA A 118 | None | 1.08A | 5d0xY-4dioA:undetectable5d0xZ-4dioA:undetectable | 5d0xY-4dioA:20.955d0xZ-4dioA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 5 | ALA A 111THR A 110ALA A 131GLY A 56GLY A 57 | NoneNoneNoneADN A 500 (-3.5A)ADN A 500 (-3.7A) | 1.01A | 5d0xY-4e3aA:undetectable5d0xZ-4e3aA:undetectable | 5d0xY-4e3aA:21.495d0xZ-4e3aA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4e | ATP-DEPENDENTPROTEASE SUBUNITHSLV (Escherichiacoli) |
PF00227(Proteasome) | 5 | ALA A 20THR A 21LYS A 33GLY A 48GLY A 49 | None | 0.57A | 5d0xY-4g4eA:10.85d0xZ-4g4eA:18.8 | 5d0xY-4g4eA:27.605d0xZ-4g4eA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4n | INTRACELLULARPROTEASE/AMIDASE (Vibrio cholerae) |
no annotation | 5 | SER A 186ALA A 210GLY A 156GLY A 157ASP A 216 | None | 1.02A | 5d0xY-4i4nA:undetectable5d0xZ-4i4nA:undetectable | 5d0xY-4i4nA:21.055d0xZ-4i4nA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k5r | OXYGENASE (Streptomycesargillaceus) |
PF01494(FAD_binding_3) | 5 | ALA A 124ALA A 121GLY A 35GLY A 34ALA A 33 | None | 0.88A | 5d0xY-4k5rA:undetectable5d0xZ-4k5rA:undetectable | 5d0xY-4k5rA:17.115d0xZ-4k5rA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mbg | CAAXFARNESYLTRANSFERASEBETA SUBUNIT RAM1 (Aspergillusfumigatus) |
PF00432(Prenyltrans) | 5 | SER B 202ALA B 206GLY B 192GLY B 193ALA B 183 | None | 1.08A | 5d0xY-4mbgB:undetectable5d0xZ-4mbgB:undetectable | 5d0xY-4mbgB:16.705d0xZ-4mbgB:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mif | PYRANOSE 2-OXIDASE (Phanerochaetechrysosporium) |
PF05199(GMC_oxred_C) | 5 | THR A 27ALA A 29GLY A 585GLY A 584ALA A 331 | NoneNoneFDA A 801 (-3.4A)NoneNone | 1.01A | 5d0xY-4mifA:undetectable5d0xZ-4mifA:undetectable | 5d0xY-4mifA:16.555d0xZ-4mifA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ou4 | ALPHA/BETA HYDROLASEFOLD-3 DOMAINPROTEIN (Pseudomonas sp.ECU1011) |
PF07859(Abhydrolase_3) | 5 | THR A 252ALA A 253GLY A 162ALA A 159ASP A 287 | None | 1.00A | 5d0xY-4ou4A:undetectable5d0xZ-4ou4A:undetectable | 5d0xY-4ou4A:21.655d0xZ-4ou4A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p98 | EXTRACELLULARSOLUTE-BINDINGPROTEIN (Conexibacterwoesei) |
PF02608(Bmp) | 5 | THR A 174ALA A 173GLY A 148GLY A 181ALA A 180 | None BR A 406 ( 4.7A)NoneNone BR A 421 (-4.1A) | 0.99A | 5d0xY-4p98A:undetectable5d0xZ-4p98A:undetectable | 5d0xY-4p98A:20.655d0xZ-4p98A:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qhb | UNCHARACTERIZEDPROTEIN (Bacteroidesvulgatus) |
PF09112(N-glycanase_N)PF09113(N-glycanase_C) | 5 | ALA A 339THR A 348ALA A 338GLY A 345GLY A 342 | None | 1.03A | 5d0xY-4qhbA:undetectable5d0xZ-4qhbA:undetectable | 5d0xY-4qhbA:19.185d0xZ-4qhbA:23.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qv9 | PROTEASOME SUBUNITBETA TYPE-5 (Saccharomycescerevisiae) |
PF00227(Proteasome) | 5 | ALA K 20THR K 21ALA K 27LYS K 33GLY K 47 | None | 0.81A | 5d0xY-4qv9K:38.65d0xZ-4qv9K:23.3 | 5d0xY-4qv9K:99.065d0xZ-4qv9K:21.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qv9 | PROTEASOME SUBUNITBETA TYPE-5 (Saccharomycescerevisiae) |
PF00227(Proteasome) | 7 | ALA K 20THR K 21ALA K 27LYS K 33GLY K 47GLY K 48ALA K 49 | None | 0.51A | 5d0xY-4qv9K:38.65d0xZ-4qv9K:23.3 | 5d0xY-4qv9K:99.065d0xZ-4qv9K:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvs | PROBABLE QUINONEREDUCTASE QOR(NADPH:QUINONEREDUCTASE)(ZETA-CRYSTALLINHOMOLOG PROTEIN) (Mycobacteriumtuberculosis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 186ALA A 188GLY A 154GLY A 153ALA A 152 | None | 1.05A | 5d0xY-4rvsA:undetectable5d0xZ-4rvsA:undetectable | 5d0xY-4rvsA:21.995d0xZ-4rvsA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqt | D-HYDANTOINASE (Brucella suis) |
PF01979(Amidohydro_1) | 5 | ALA A 82THR A 81GLY A 88GLY A 87ALA A 86 | None | 1.07A | 5d0xY-4tqtA:undetectable5d0xZ-4tqtA:undetectable | 5d0xY-4tqtA:17.745d0xZ-4tqtA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zm6 | N-ACETYL-BETA-DGLUCOSAMINIDASE (Rhizomucormiehei) |
PF00583(Acetyltransf_1)PF00933(Glyco_hydro_3) | 5 | ALA A 505ALA A 508GLY A 84GLY A 98ALA A 101 | None | 1.03A | 5d0xY-4zm6A:undetectable5d0xZ-4zm6A:undetectable | 5d0xY-4zm6A:13.685d0xZ-4zm6A:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ahm | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Pseudomonasaeruginosa) |
PF00478(IMPDH) | 5 | ALA A 278THR A 279ALA A 319GLY A 251GLY A 275 | None | 1.07A | 5d0xY-5ahmA:undetectable5d0xZ-5ahmA:undetectable | 5d0xY-5ahmA:20.555d0xZ-5ahmA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c54 | DIHYDRODIPICOLINATESYNTHASE/N-ACETYLNEURAMINATE LYASE (Corynebacteriumglutamicum) |
PF00701(DHDPS) | 5 | ALA A 79THR A 78ALA A 45GLY A 100ALA A 99 | None | 0.97A | 5d0xY-5c54A:undetectable5d0xZ-5c54A:undetectable | 5d0xY-5c54A:23.105d0xZ-5c54A:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d8w | ENDOGLUCANASE (Ganodermalucidum) |
PF00150(Cellulase) | 5 | ALA A 184THR A 183ALA A 181GLY A 189ALA A 148 | None | 0.96A | 5d0xY-5d8wA:undetectable5d0xZ-5d8wA:undetectable | 5d0xY-5d8wA:20.835d0xZ-5d8wA:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dip | ALKYL HYDROPEROXIDEREDUCTASE AHPD (Legionellapneumophila) |
PF02627(CMD) | 5 | ALA A 101ALA A 104GLY A 94GLY A 93ALA A 89 | None | 0.99A | 5d0xY-5dipA:undetectable5d0xZ-5dipA:undetectable | 5d0xY-5dipA:20.775d0xZ-5dipA:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fb3 | GLYCEROL-1-PHOSPHATEDEHYDROGENASE[NAD(P)+] (Pyrobaculumcalidifontis) |
PF13685(Fe-ADH_2) | 5 | SER A 190ALA A 164GLY A 219GLY A 221ALA A 223 | None | 1.06A | 5d0xY-5fb3A:undetectable5d0xZ-5fb3A:undetectable | 5d0xY-5fb3A:19.305d0xZ-5fb3A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fg9 | PROTEASOME SUBUNITBETA TYPE-2 (Saccharomycescerevisiae) |
PF00227(Proteasome)PF12465(Pr_beta_C) | 5 | THR H 21ALA H 27LYS H 33GLY H 47ALA H 49 | None | 0.50A | 5d0xY-5fg9H:21.05d0xZ-5fg9H:23.1 | 5d0xY-5fg9H:29.345d0xZ-5fg9H:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | BETA3 PROTEASOMESUBUNIT, PUTATIVEPROTEASOME SUBUNITBETA TYPE (Plasmodiumfalciparum) |
PF00227(Proteasome) | 6 | ALA I 20THR I 21ALA I 27LYS I 33GLY I 47ASP J 138 | 7F1 I 300 (-3.6A)None7F1 I 300 ( 3.8A)7F1 I 300 (-4.7A)7F1 I 300 (-3.8A)7F1 I 300 (-2.6A) | 1.10A | 5d0xY-5fmgI:21.45d0xZ-5fmgI:23.4 | 5d0xY-5fmgI:25.865d0xZ-5fmgI:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITBETA TYPE (Plasmodiumfalciparum) |
PF00227(Proteasome) | 5 | ALA I 20THR I 21ALA I 27LYS I 33GLY I 47 | 7F1 I 300 (-3.6A)None7F1 I 300 ( 3.8A)7F1 I 300 (-4.7A)7F1 I 300 (-3.8A) | 0.96A | 5d0xY-5fmgI:21.45d0xZ-5fmgI:23.4 | 5d0xY-5fmgI:25.865d0xZ-5fmgI:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITBETA TYPE (Plasmodiumfalciparum) |
PF00227(Proteasome) | 6 | ALA I 20THR I 21ALA I 27LYS I 33GLY I 47ALA I 49 | 7F1 I 300 (-3.6A)None7F1 I 300 ( 3.8A)7F1 I 300 (-4.7A)7F1 I 300 (-3.8A)7F1 I 300 (-3.5A) | 0.76A | 5d0xY-5fmgI:21.45d0xZ-5fmgI:23.4 | 5d0xY-5fmgI:25.865d0xZ-5fmgI:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gms | ESTERASE (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | ALA A 125THR A 122ALA A 124GLY A 104ALA A 57 | None | 1.06A | 5d0xY-5gmsA:undetectable5d0xZ-5gmsA:undetectable | 5d0xY-5gmsA:19.545d0xZ-5gmsA:22.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l5w | PROTEASOME SUBUNITBETATYPE-5,PROTEASOMESUBUNIT BETA TYPE-5 (Homo sapiens;Saccharomycescerevisiae) |
PF00227(Proteasome) | 7 | ALA K 20THR K 21ALA K 27LYS K 33GLY K 47GLY K 48ALA K 49 | None | 0.73A | 5d0xY-5l5wK:29.55d0xZ-5l5wK:23.5 | 5d0xY-5l5wK:82.085d0xZ-5l5wK:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lu2 | 14-3-3 PROTEIN SIGMA (Homo sapiens) |
PF00244(14-3-3) | 5 | SER A 158ALA A 154ALA A 150GLY A 171ASP A 126 | None | 1.03A | 5d0xY-5lu2A:undetectable5d0xZ-5lu2A:undetectable | 5d0xY-5lu2A:20.495d0xZ-5lu2A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m23 | WD REPEAT-CONTAININGPROTEIN 5 (Homo sapiens) |
PF00400(WD40) | 5 | ALA A 317ALA A 308GLY A 77GLY A 73ALA A 74 | None | 1.04A | 5d0xY-5m23A:undetectable5d0xZ-5m23A:undetectable | 5d0xY-5m23A:20.845d0xZ-5m23A:19.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t0g | PROTEASOME SUBUNITBETA TYPE-5 (Homo sapiens) |
PF00227(Proteasome) | 5 | ALA R 20LYS R 33GLY R 47GLY R 48ALA R 49 | None | 0.64A | 5d0xY-5t0gR:24.65d0xZ-5t0gR:23.9 | 5d0xY-5t0gR:51.715d0xZ-5t0gR:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tf0 | GLYCOSYL HYDROLASEFAMILY 3 N-TERMINALDOMAIN PROTEIN (Bacteroidesintestinalis) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | ALA A 421ALA A 509GLY A 424GLY A 468ALA A 466 | None | 1.02A | 5d0xY-5tf0A:undetectable5d0xZ-5tf0A:undetectable | 5d0xY-5tf0A:13.805d0xZ-5tf0A:15.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uni | NAD(P)TRANSHYDROGENASESUBUNIT BETA (Thermusthermophilus) |
PF02233(PNTB) | 5 | ALA B 229ALA B 42GLY B 219GLY B 234ALA B 233 | None | 1.07A | 5d0xY-5uniB:undetectable5d0xZ-5uniB:undetectable | 5d0xY-5uniB:20.975d0xZ-5uniB:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vfr | PROTEASOME SUBUNITBETA TYPE-5 (Homo sapiens) |
no annotation | 7 | ALA R 20THR R 21ALA R 27LYS R 33GLY R 47GLY R 48ALA R 49 | None | 0.53A | 5d0xY-5vfrR:19.35d0xZ-5vfrR:23.6 | 5d0xY-5vfrR:undetectable5d0xZ-5vfrR:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vlh | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8)PF05922(Inhibitor_I9) | 6 | SER A 401ALA A 397ALA A 393GLY A 176GLY A 244ALA A 245 | None | 1.24A | 5d0xY-5vlhA:undetectable5d0xZ-5vlhA:undetectable | 5d0xY-5vlhA:18.525d0xZ-5vlhA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7s | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE (Paenibacillussp. 598K) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 5 | ALA A1028ALA A 994GLY A1001GLY A1002ASP A1019 | None | 1.08A | 5d0xY-5x7sA:undetectable5d0xZ-5x7sA:undetectable | 5d0xY-5x7sA:10.335d0xZ-5x7sA:11.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7s | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE (Paenibacillussp. 598K) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 5 | ALA A1028ALA A 997GLY A1001GLY A1002ALA A1003 | None | 1.05A | 5d0xY-5x7sA:undetectable5d0xZ-5x7sA:undetectable | 5d0xY-5x7sA:10.335d0xZ-5x7sA:11.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xuo | POLYKETIDE SYNTHASEPKS13 (Mycobacteriumtuberculosis) |
no annotation | 5 | ALA A 819ALA A 822GLY A 813GLY A 812ALA A 808 | None | 0.79A | 5d0xY-5xuoA:undetectable5d0xZ-5xuoA:undetectable | 5d0xY-5xuoA:17.995d0xZ-5xuoA:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6avo | PROTEASOME SUBUNITBETA TYPE-10 (Homo sapiens) |
no annotation | 6 | ALA B 20THR B 21ALA B 27LYS B 33GLY B 47ALA B 49 | None | 0.58A | 5d0xY-6avoB:12.45d0xZ-6avoB:20.9 | 5d0xY-6avoB:19.895d0xZ-6avoB:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bar | ROD SHAPEDETERMINING PROTEINRODA (Thermusthermophilus) |
no annotation | 5 | ALA A 341THR A 342ALA A 344GLY A 335GLY A 336 | OLC A 402 (-3.7A)NoneOLC A 402 ( 3.9A)NoneOLC A 402 ( 4.7A) | 1.06A | 5d0xY-6barA:undetectable5d0xZ-6barA:undetectable | 5d0xY-6barA:17.265d0xZ-6barA:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bm8 | ENVELOPEGLYCOPROTEIN B (Humanalphaherpesvirus1) |
no annotation | 5 | ALA A 211THR A 221ALA A 222ALA A 190ASP A 188 | None | 0.94A | 5d0xY-6bm8A:undetectable5d0xZ-6bm8A:undetectable | 5d0xY-6bm8A:15.095d0xZ-6bm8A:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byn | WD REPEAT-CONTAININGPROTEIN 5 (Homo sapiens) |
no annotation | 5 | ALA W 317ALA W 308GLY W 77GLY W 73ALA W 74 | None | 0.95A | 5d0xY-6bynW:undetectable5d0xZ-6bynW:undetectable | 5d0xY-6bynW:20.115d0xZ-6bynW:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MONOVALENT CATION/H+ANTIPORTER SUBUNIT B (Pyrococcusfuriosus) |
no annotation | 5 | ALA F 43THR F 44ALA F 46GLY F 37GLY F 38 | None | 1.07A | 5d0xY-6cfwF:undetectable5d0xZ-6cfwF:undetectable | 5d0xY-6cfwF:17.825d0xZ-6cfwF:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cyz | HOMOSERINE KINASE (Mycobacteroidesabscessus) |
no annotation | 5 | ALA A 169THR A 170GLY A 152GLY A 151ASP A 128 | None | 1.07A | 5d0xY-6cyzA:undetectable5d0xZ-6cyzA:undetectable | 5d0xY-6cyzA:19.005d0xZ-6cyzA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fel | 14-3-3 PROTEIN GAMMA (Homo sapiens) |
no annotation | 5 | SER A 161ALA A 157ALA A 153GLY A 174ASP A 129 | None | 1.05A | 5d0xY-6felA:undetectable5d0xZ-6felA:undetectable | 5d0xY-6felA:16.265d0xZ-6felA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbh | HOPQ (Helicobacterpylori) |
no annotation | 5 | ALA C 59THR C 58ALA C 57GLY C 65ALA C 63 | None | 0.86A | 5d0xY-6gbhC:undetectable5d0xZ-6gbhC:undetectable | 5d0xY-6gbhC:15.615d0xZ-6gbhC:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gu8 | - (-) |
no annotation | 5 | SER A 278ALA A 262ALA A 230GLY A 285GLY A 284 | None | 0.98A | 5d0xY-6gu8A:undetectable5d0xZ-6gu8A:undetectable | 5d0xY-6gu8A:undetectable5d0xZ-6gu8A:undetectable |