SIMILAR PATTERNS OF AMINO ACIDS FOR 5CZY_A_SAMA603

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		5 LEU A 190
GLY A 189
ARG A 210
SER A 217
TYR A 192
 None
 1.37A 5czyA-1bt4A:
0.0		 5czyA-1bt4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 ARG A 402
SER A  40
TYR A 324
TYR A 455
LEU A 462
 None
 1.41A 5czyA-1i7qA:
0.0		 5czyA-1i7qA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A  33
GLY A  32
SER A  51
TYR A 114
LEU A 118
 NIY  A 114 ( 4.1A)
None
FAD  A 499 (-3.1A)
NIY  A 114 ( 1.2A)
NIY  A 114 ( 3.9A)
 0.96A 5czyA-1k4qA:
0.0		 5czyA-1k4qA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		5 TYR A6016
ASN A6001
GLU A5961
TYR A5926
TYR A5927
 None
 1.37A 5czyA-1koaA:
0.0		 5czyA-1koaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		5 LEU A 447
GLY A 110
ARG A 111
TYR A 113
LEU A  17
 None
 1.20A 5czyA-1lfwA:
0.0		 5czyA-1lfwA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A

(Escherichia
coli) 		PF02861
(Clp_N) 		5 LEU A 109
ARG A 131
SER A 118
GLU A  28
LEU A  44
 None
 1.35A 5czyA-1mbxA:
undetectable		 5czyA-1mbxA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ors 33H1 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  99
TYR B  51
PHE B  95
TYR B 107
LEU B   4
 None
 1.24A 5czyA-1orsB:
undetectable		 5czyA-1orsB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r94 PROTEIN YFHF

(Escherichia
coli) 		PF01521
(Fe-S_biosyn) 		5 GLY A  59
SER A   8
ASN A  14
PHE A  16
LEU A  17
 None
 1.39A 5czyA-1r94A:
0.0		 5czyA-1r94A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG

(Homo sapiens) 		PF03657
(UPF0113) 		5 LEU A  81
GLY A  71
TYR A  45
TYR A  19
LEU A  89
 None
 1.25A 5czyA-1sqwA:
0.0		 5czyA-1sqwA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tii HEAT LABILE
ENTEROTOXIN TYPE IIB

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		5 LEU A  99
GLY A 100
GLU A 108
TYR A  40
LEU A  39
 None
 1.41A 5czyA-1tiiA:
0.0		 5czyA-1tiiA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		5 LEU A 640
ARG A 672
TYR A 670
TYR A 592
LEU A 607
 LEU  A 640 ( 0.5A)
ARG  A 672 ( 0.6A)
TYR  A 670 ( 1.3A)
TYR  A 592 ( 1.3A)
LEU  A 607 ( 0.5A)
 1.33A 5czyA-1v0fA:
undetectable		 5czyA-1v0fA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF01522
(Polysacc_deac_1) 		5 ARG A 268
PHE A 100
TYR A 211
TYR A  35
LEU A  33
 None
 1.09A 5czyA-1z7aA:
undetectable		 5czyA-1z7aA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0l 33H1 FV FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 GLY D  99
TYR D  51
PHE D  95
TYR D 107
LEU D   4
 None
 1.08A 5czyA-2a0lD:
undetectable		 5czyA-2a0lD:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		5 GLY A 356
SER A 257
PHE A 253
GLU A 233
LEU A 252
 None
 1.13A 5czyA-2fvmA:
0.9		 5czyA-2fvmA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		5 LEU A 531
GLY A 530
ARG A 533
ASN A 503
LEU A 506
 None
 1.34A 5czyA-2g28A:
undetectable		 5czyA-2g28A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Sulfurisphaera
tokodaii) 		PF04321
(RmlD_sub_bind) 		5 GLY A 270
ARG A 187
PHE A 160
TYR A 181
TYR A 165
 None
 1.28A 5czyA-2ggsA:
undetectable		 5czyA-2ggsA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 471
GLY A 472
ARG A 474
TYR A 457
LEU A 450
 None
 1.26A 5czyA-2oaeA:
undetectable		 5czyA-2oaeA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oj4 REGULATOR OF
G-PROTEIN SIGNALING
3

(Homo sapiens) 		PF00615
(RGS) 		5 LEU A  22
GLY A  21
SER A  11
GLU A  13
LEU A  38
 None
 1.15A 5czyA-2oj4A:
undetectable		 5czyA-2oj4A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oj4 REGULATOR OF
G-PROTEIN SIGNALING
3

(Homo sapiens) 		PF00615
(RGS) 		5 LEU A  22
GLY A  21
TYR A 123
GLU A  13
LEU A  38
 None
 1.23A 5czyA-2oj4A:
undetectable		 5czyA-2oj4A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjz HYPOTHETICAL PROTEIN
ST1066

(Sulfurisphaera
tokodaii) 		PF00005
(ABC_tran) 		5 LEU A 185
GLY A 252
ARG A 256
SER A 217
LEU A  36
 None
 1.25A 5czyA-2pjzA:
undetectable		 5czyA-2pjzA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtv SMALL COPII COAT
GTPASE SAR1
PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00025
(Arf)
PF11549
(Sec31) 		5 LEU B  74
GLY B  75
SER D 908
TYR B  87
LEU B  27
 None
GNP  B 200 ( 4.0A)
None
None
None
 1.39A 5czyA-2qtvB:
undetectable		 5czyA-2qtvB:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmr PROTEIN NDRG2

(Homo sapiens) 		PF03096
(Ndr) 		5 LEU A  52
TYR A  61
TYR A 219
TYR A 141
LEU A 138
 None
 1.29A 5czyA-2xmrA:
undetectable		 5czyA-2xmrA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6t ECOTIN

(Yersinia
pseudotuberculosis) 		PF03974
(Ecotin) 		5 LEU E  85
ARG E  88
SER E  47
TYR E  97
LEU E  66
 None
 1.25A 5czyA-2y6tE:
undetectable		 5czyA-2y6tE:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		5 LEU A 324
SER A  94
ASN A  53
TYR A  45
LEU A  49
 None
 1.10A 5czyA-2zwaA:
undetectable		 5czyA-2zwaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a68 FERRITIN-4,
CHLOROPLASTIC

(Glycine max) 		PF00210
(Ferritin) 		5 LEU A 171
GLY A 172
ASN A 144
GLU A  56
LEU A 148
 None
CA  A 215 ( 4.6A)
None
CA  A 214 (-2.9A)
None
 1.04A 5czyA-3a68A:
undetectable		 5czyA-3a68A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a71 EXO-ARABINANASE

(Penicillium
chrysogenum) 		no annotation 5 GLY A 101
ARG A 103
TYR A 104
TYR A 142
LEU A 125
 None
None
ACT  A 401 (-3.6A)
None
None
 1.34A 5czyA-3a71A:
undetectable		 5czyA-3a71A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq4 ADP-RIBOSYLATION
FACTOR 1

(Arabidopsis
thaliana) 		PF00025
(Arf) 		5 LEU A 145
GLY A 144
ARG A 104
SER A  94
LEU A 121
 None
 1.22A 5czyA-3aq4A:
undetectable		 5czyA-3aq4A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 LEU A 105
GLY A  61
ARG A  65
PHE A  79
LEU A 110
 None
 1.34A 5czyA-3b3dA:
undetectable		 5czyA-3b3dA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 LEU A 488
GLY A 500
ARG A 463
TYR A 461
PHE A 510
 None
 1.27A 5czyA-3b9eA:
undetectable		 5czyA-3b9eA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		5 GLY A 288
GLU A 202
TYR A 242
TYR A 250
LEU A 241
 None
 1.33A 5czyA-3bwsA:
undetectable		 5czyA-3bwsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 LEU A 609
SER A 594
TYR A 599
GLU A 201
TYR A 616
 None
 1.32A 5czyA-3cihA:
undetectable		 5czyA-3cihA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens) 		PF01522
(Polysacc_deac_1) 		5 ARG A 268
PHE A 100
TYR A 211
TYR A  35
LEU A  33
 None
 1.12A 5czyA-3cl6A:
undetectable		 5czyA-3cl6A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqg NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		5 LEU A 754
ARG A 751
PHE A 699
GLU A 710
LEU A 700
 None
 1.32A 5czyA-3cqgA:
undetectable		 5czyA-3cqgA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli) 		PF01274
(Malate_synthase) 		5 LEU A 172
GLY A 169
SER A 121
TYR A 428
TYR A 529
 None
None
CSO  A 438 ( 4.8A)
None
None
 1.22A 5czyA-3cv2A:
undetectable		 5czyA-3cv2A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzt D7 PROTEIN

(Aedes aegypti) 		PF01395
(PBP_GOBP) 		5 LEU A 229
PHE A 264
TYR A 199
TYR A 247
LEU A 251
 None
GOL  A 307 (-4.6A)
None
None
None
 1.23A 5czyA-3dztA:
undetectable		 5czyA-3dztA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euk CHROMOSOME PARTITION
PROTEIN MUKE

([Haemophilus]
ducreyi) 		PF04288
(MukE) 		5 LEU L 158
GLY L 155
TYR L 120
PHE L 114
LEU L  98
 None
 1.14A 5czyA-3eukL:
undetectable		 5czyA-3eukL:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 137
ARG A 136
SER A 298
TYR A 132
LEU A 151
 None
 1.25A 5czyA-3gp0A:
undetectable		 5czyA-3gp0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqi PHOSPHOLIPASE
C-GAMMA-1

(Rattus
norvegicus) 		PF00017
(SH2) 		5 LEU B 597
ARG B 586
SER B 546
TYR B 639
LEU B 653
 None
 1.09A 5czyA-3gqiB:
undetectable		 5czyA-3gqiB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l CYTOCHROME B
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN

(Gallus gallus;
Gallus gallus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02271
(UCR_14kD) 		5 GLY C 211
ARG C 314
TYR F  38
TYR F  29
LEU F  31
 None
 1.24A 5czyA-3h1lC:
undetectable		 5czyA-3h1lC:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		5 LEU A 229
GLY A 228
SER A  19
PHE A 425
LEU A 237
 None
 1.34A 5czyA-3h6eA:
undetectable		 5czyA-3h6eA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		5 LEU A 221
GLY A 218
SER A 292
TYR A 252
TYR A 186
 None
 1.38A 5czyA-3k40A:
undetectable		 5czyA-3k40A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 LEU A 504
GLY A 503
ARG A 517
TYR A 518
LEU A 549
 None
 1.34A 5czyA-3l4kA:
undetectable		 5czyA-3l4kA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		5 LEU A 366
GLY A 367
ARG A 364
GLU A 272
LEU A 231
 None
 1.35A 5czyA-3lmmA:
undetectable		 5czyA-3lmmA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmk NUCLEOCAPSID PROTEIN

(Recombinant
vesicular
stomatitis
Indiana virus
rVSV-G/GFP) 		PF00945
(Rhabdo_ncap) 		5 LEU A  59
GLY A  58
TYR A  54
TYR A 137
LEU A 138
 None
 1.04A 5czyA-3pmkA:
undetectable		 5czyA-3pmkA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 LEU A 451
GLY A 450
GLU A 431
TYR A 427
LEU A 465
 None
 1.35A 5czyA-3q60A:
undetectable		 5czyA-3q60A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzn IRON-REGULATED
SURFACE DETERMINANT
PROTEIN A

(Staphylococcus
aureus) 		PF05031
(NEAT) 		5 GLY A 149
TYR A 101
PHE A  71
GLU A 177
LEU A 153
 None
 1.36A 5czyA-3qznA:
undetectable		 5czyA-3qznA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6o POLYSACCHARIDE
DEACETYLASE FAMILY
PROTEIN

(Burkholderia
pseudomallei) 		PF01522
(Polysacc_deac_1) 		5 ARG A 272
PHE A 101
TYR A 215
TYR A  37
LEU A  35
 None
 1.01A 5czyA-3s6oA:
undetectable		 5czyA-3s6oA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		5 TYR B 224
ASN B 180
GLU B 118
TYR B 177
LEU B 176
 None
 1.32A 5czyA-3t5vB:
undetectable		 5czyA-3t5vB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		5 GLY A 510
ASN A 519
PHE A 518
TYR A 223
LEU A 222
 None
 1.27A 5czyA-3vtaA:
undetectable		 5czyA-3vtaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3win HA3

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		5 SER E 213
ASN E 456
TYR E 217
TYR E 432
TYR E 480
 None
 1.39A 5czyA-3winE:
undetectable		 5czyA-3winE:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA

(Dictyostelium
discoideum) 		PF01115
(F_actin_cap_B) 		5 GLY B 114
SER B 153
PHE B 104
GLU B 223
TYR B 107
 None
 0.95A 5czyA-4akrB:
undetectable		 5czyA-4akrB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA

(Dictyostelium
discoideum) 		PF01115
(F_actin_cap_B) 		5 GLY B 115
SER B 153
PHE B 104
GLU B 223
TYR B 107
 None
 1.07A 5czyA-4akrB:
undetectable		 5czyA-4akrB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 GLY A 193
SER A 217
PHE A 232
TYR A 241
LEU A 240
 None
 1.37A 5czyA-4cztA:
undetectable		 5czyA-4cztA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3w ACID PHOSPHATASE

(Francisella
tularensis) 		PF00328
(His_Phos_2) 		5 SER A  88
TYR A 256
GLU A  48
TYR A 302
LEU A 285
 None
 1.32A 5czyA-4e3wA:
undetectable		 5czyA-4e3wA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3h ARGINASE (ROCF)

(Helicobacter
pylori) 		PF00491
(Arginase) 		5 LEU A   6
GLY A   5
SER A 232
TYR A  50
LEU A  70
 None
 1.27A 5czyA-4g3hA:
undetectable		 5czyA-4g3hA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		5 LEU A 504
GLY A 503
ARG A 517
TYR A 518
LEU A 549
 None
 1.36A 5czyA-4gfhA:
undetectable		 5czyA-4gfhA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		5 LEU A 504
GLY A 503
TYR A 518
GLU A 494
LEU A 542
 None
 1.35A 5czyA-4gfhA:
undetectable		 5czyA-4gfhA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		5 LEU A 171
GLY A 172
PHE A 141
TYR A 154
LEU A 142
 None
 1.19A 5czyA-4iaoA:
undetectable		 5czyA-4iaoA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipn 6-PHOSPHO-BETA-GLUCO
SIDASE

(Streptococcus
pneumoniae) 		PF00232
(Glyco_hydro_1) 		5 GLY B  57
SER B  82
TYR B 105
GLU B 127
TYR B  23
 None
 1.24A 5czyA-4ipnB:
0.9		 5czyA-4ipnB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		5 LEU A 336
GLY A 337
ARG A 382
TYR A 403
LEU A 407
 None
 1.34A 5czyA-4j5tA:
undetectable		 5czyA-4j5tA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks9 MALONYL-COA
DECARBOXYLASE

(Cupriavidus
metallidurans) 		PF05292
(MCD)
PF17408
(MCD_N) 		5 LEU A 232
ARG A 237
SER A 289
TYR A 239
LEU A 210
 None
 1.18A 5czyA-4ks9A:
2.3		 5czyA-4ks9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		5 LEU A 376
GLY A 375
GLU A  80
TYR A 340
LEU A 337
 None
 1.33A 5czyA-4kv7A:
undetectable		 5czyA-4kv7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 PHE A 543
GLU A 539
TYR A 566
TYR A 567
LEU A 563
 None
 1.21A 5czyA-4lixA:
undetectable		 5czyA-4lixA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omb PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		5 LEU A 321
GLY A 322
PHE A 288
TYR A  62
LEU A 293
 None
 1.33A 5czyA-4ombA:
undetectable		 5czyA-4ombA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovk PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		5 LEU A 347
ARG A 332
PHE A 342
TYR A 184
TYR A 345
 None
None
None
PGE  A 401 (-3.6A)
None
 1.37A 5czyA-4ovkA:
undetectable		 5czyA-4ovkA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2w PUTATIVE
ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Streptococcus
pneumoniae) 		PF01832
(Glucosaminidase) 		5 LEU A 121
GLY A 120
SER A  62
TYR A 264
ASN A 250
 None
 1.23A 5czyA-4q2wA:
undetectable		 5czyA-4q2wA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A 265
ARG A 407
SER A 420
GLU A 102
TYR A 287
 None
 1.03A 5czyA-4rjkA:
undetectable		 5czyA-4rjkA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A  84
GLY A  88
SER A 406
GLU A 427
LEU A 131
 None
 1.32A 5czyA-4rvwA:
undetectable		 5czyA-4rvwA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		5 LEU A  89
GLY A  48
ARG A 327
GLU A 120
LEU A 100
 None
 1.31A 5czyA-4u9cA:
undetectable		 5czyA-4u9cA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeb GLUCANASE

(Talaromyces
funiculosus) 		PF00840
(Glyco_hydro_7) 		5 LEU A 353
GLY A 352
PHE A 260
GLU A 337
TYR A 333
 None
None
None
CL  A 510 ( 4.6A)
None
 1.22A 5czyA-4xebA:
undetectable		 5czyA-4xebA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt8 RV2671

(Mycobacterium
tuberculosis) 		PF01872
(RibD_C) 		5 SER A  59
TYR A 252
ASN A  44
GLU A  91
LEU A 191
 TMQ  A 302 ( 3.0A)
None
TMQ  A 302 (-2.9A)
TMQ  A 302 ( 3.2A)
None
 1.28A 5czyA-4xt8A:
undetectable		 5czyA-4xt8A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybg PROTEIN MAELSTROM

(Drosophila
melanogaster) 		PF13017
(Maelstrom) 		5 LEU A 174
ARG A 296
TYR A 299
ASN A 116
PHE A 115
 None
 1.38A 5czyA-4ybgA:
undetectable		 5czyA-4ybgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		5 LEU A 107
GLY A 106
SER A  91
PHE A 191
TYR A 258
 None
 1.21A 5czyA-4zpdA:
undetectable		 5czyA-4zpdA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 232
TYR A 239
PHE A 558
TYR A 228
LEU A 519
 None
 1.25A 5czyA-5agaA:
undetectable		 5czyA-5agaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)

(Bdellovibrio
bacteriovorus) 		PF06963
(FPN1) 		5 GLY A 138
ARG A  17
ASN A 155
GLU A 358
LEU A 151
 None
 1.17A 5czyA-5aynA:
undetectable		 5czyA-5aynA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmn LATROPHILIN-3

(Homo sapiens) 		PF02191
(OLF) 		5 LEU E 233
GLY E 216
TYR E 214
TYR E 200
LEU E 182
 None
 1.37A 5czyA-5cmnE:
undetectable		 5czyA-5cmnE:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5czy LEGIONELLA EFFECTOR
LEGAS4

(Legionella
pneumophila) 		PF00023
(Ank)
PF00856
(SET) 		12 LEU A 125
GLY A 130
ARG A 131
SER A 171
TYR A 192
ASN A 194
PHE A 195
TYR A 233
GLU A 238
TYR A 244
TYR A 245
LEU A 247
 None
SAM  A 603 ( 3.8A)
None
SAM  A 603 (-3.1A)
SAM  A 603 (-4.8A)
SAM  A 603 (-3.2A)
None
None
SAM  A 603 (-3.0A)
SAM  A 603 (-3.9A)
GOL  A 604 (-4.0A)
SAM  A 603 (-4.0A)
 0.01A 5czyA-5czyA:
60.2		 5czyA-5czyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gv1 ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		5 GLY A 246
SER A 111
PHE A 252
TYR A 121
LEU A 242
 None
 1.40A 5czyA-5gv1A:
undetectable		 5czyA-5gv1A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 5 LEU A 519
SER A 306
PHE A 495
TYR A 482
LEU A 505
 None
 1.20A 5czyA-5h2tA:
undetectable		 5czyA-5h2tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 LEU A  43
ARG A  32
GLU A 258
TYR A  81
LEU A  98
 None
 1.28A 5czyA-5i6vA:
undetectable		 5czyA-5i6vA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir2 CELLULASE

(Parabacteroides
johnsonii) 		PF03737
(RraA-like) 		5 LEU A 196
GLY A 197
TYR A  73
PHE A  39
TYR A  41
 None
 1.36A 5czyA-5ir2A:
undetectable		 5czyA-5ir2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  23
ARG A  21
TYR A  31
GLU A  61
LEU A 143
 None
None
None
None
6G2  A 901 (-4.7A)
 1.40A 5czyA-5j5tA:
undetectable		 5czyA-5j5tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		5 LEU A 159
GLY A 172
SER A 185
PHE A 192
GLU A  68
 None
 1.12A 5czyA-5jp9A:
undetectable		 5czyA-5jp9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE

(Arabidopsis
thaliana) 		PF03254
(XG_FTase) 		5 TYR A 195
PHE A 328
TYR A 302
TYR A 334
LEU A 335
 None
 1.35A 5czyA-5kx6A:
undetectable		 5czyA-5kx6A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		5 LEU B 144
TYR B 141
TYR B 359
TYR B 216
LEU B 154
 None
 1.15A 5czyA-5lxzB:
undetectable		 5czyA-5lxzB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 LEU A 708
TYR A 705
PHE A 647
GLU A 584
LEU A 689
 None
 1.40A 5czyA-5n6uA:
undetectable		 5czyA-5n6uA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 5 LEU A  48
GLY A  52
ARG A  23
SER A 410
LEU A 366
 None
None
8U8  A 713 ( 3.7A)
None
None
 1.19A 5czyA-5ndxA:
1.5		 5czyA-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 LEU A 794
GLY A 457
TYR A 764
TYR A 412
LEU A 411
 None
 1.38A 5czyA-5o0sA:
undetectable		 5czyA-5o0sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 5 LEU B 316
ARG B 248
TYR B 638
TYR B 625
LEU B 613
 None
 1.38A 5czyA-5swiB:
0.7		 5czyA-5swiB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo sapiens) 		no annotation 5 LEU A 362
GLY A 361
ASN A 204
PHE A 202
TYR A 338
 None
 1.24A 5czyA-5sxgA:
undetectable		 5czyA-5sxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgf UNCHARACTERIZED
PROTEIN

(Bacteroides
dorei) 		PF00144
(Beta-lactamase) 		5 LEU A 199
GLY A 200
SER A 108
TYR A 113
LEU A 125
 None
GOL  A 401 ( 4.5A)
None
GOL  A 401 (-4.8A)
None
 1.29A 5czyA-5tgfA:
undetectable		 5czyA-5tgfA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		5 LEU A 418
ARG A 415
GLU A 426
TYR A 372
LEU A 355
 None
 1.21A 5czyA-5ubkA:
undetectable		 5czyA-5ubkA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x11 TRANSCRIPTIONAL
REGULATOR

(Bacillus
subtilis) 		no annotation 5 LEU A  11
GLY A  10
TYR A   6
TYR A  25
LEU A  30
 None
 1.25A 5czyA-5x11A:
undetectable		 5czyA-5x11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum) 		no annotation 5 LEU A 386
GLY A 387
ARG A 342
TYR A 374
TYR A 415
 None
 1.40A 5czyA-5x7uA:
undetectable		 5czyA-5x7uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xau LAMININ SUBUNIT
ALPHA-5

(Homo sapiens) 		PF02210
(Laminin_G_2)
PF06009
(Laminin_II) 		5 GLY A3253
SER A3159
ASN A3257
PHE A3258
TYR A3164
 NAG  A3404 ( 4.6A)
None
NAG  A3404 (-1.9A)
None
None
 1.30A 5czyA-5xauA:
undetectable		 5czyA-5xauA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		5 LEU A 103
GLY A 102
SER A  87
PHE A 187
TYR A 254
 None
 1.17A 5czyA-5xe0A:
undetectable		 5czyA-5xe0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Helicobacter
pylori) 		no annotation 5 LEU A  84
SER A  29
PHE A  67
GLU A  32
LEU A  65
 None
 1.22A 5czyA-5xukA:
undetectable		 5czyA-5xukA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z43 AMBP1

(Fischerella
ambigua) 		no annotation 5 LEU A 263
GLY A 264
TYR A 276
TYR A 248
LEU A 241
 None
 1.27A 5czyA-5z43A:
undetectable		 5czyA-5z43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ank SYNAPTOTAGMIN-7

(Rattus
norvegicus) 		PF00168
(C2) 		5 LEU A 257
GLY A 137
ARG A 138
SER A 171
PHE A 174
 None
 1.36A 5czyA-6ankA:
undetectable		 5czyA-6ankA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus) 		no annotation 5 LEU H 187
GLY H 183
TYR H 139
TYR H 191
LEU H 199
 None
 1.24A 5czyA-6cfwH:
undetectable		 5czyA-6cfwH:
undetectable