SIMILAR PATTERNS OF AMINO ACIDS FOR 5CYQ_A_T27A601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axd GLUTATHIONE
S-TRANSFERASE I

(Zea mays) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.48A 5cyqA-1axdA:
0.0		 5cyqA-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bml STREPTOKINASE

(Streptococcus
dysgalactiae) 		PF02821
(Staphylokinase) 		5 LEU C 137
LYS C  76
VAL C 125
TYR C 117
LEU C  18
 None
 1.41A 5cyqA-1bmlC:
undetectable		 5cyqA-1bmlC:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		5 LEU A 323
VAL A 358
TYR A 364
PHE A 314
LEU A 315
 None
 1.42A 5cyqA-1floA:
0.0		 5cyqA-1floA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuk EUKARYOTIC
INITIATION FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		5 LEU A 253
VAL A 358
VAL A 259
PHE A 236
LEU A 385
 None
 1.42A 5cyqA-1fukA:
undetectable		 5cyqA-1fukA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gr0 INOSITOL-3-PHOSPHATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01658
(Inos-1-P_synth) 		5 LEU A 344
VAL A 337
VAL A 169
PHE A 364
LEU A 361
 None
 1.26A 5cyqA-1gr0A:
undetectable		 5cyqA-1gr0A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		5 PRO A 379
LYS A 365
PHE A 369
LEU A 368
TYR A 415
 None
 1.24A 5cyqA-1j2bA:
0.0		 5cyqA-1j2bA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09105
(SelB-wing_1)
PF09106
(SelB-wing_2)
PF09107
(SelB-wing_3) 		5 LEU A 518
LYS A 517
LYS A 520
TYR A 526
LEU A 553
 None
 1.49A 5cyqA-1lvaA:
0.2		 5cyqA-1lvaA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
LYS A 103
TRP A 229
LEU A 234
TYR A 318
 None
 1.08A 5cyqA-1mu2A:
28.4		 5cyqA-1mu2A:
60.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 PRO A  95
LYS A 103
TRP A 229
LEU A 234
TYR A 318
 None
 0.93A 5cyqA-1mu2A:
28.4		 5cyqA-1mu2A:
60.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox8 STRINGENT STARVATION
PROTEIN B

(Escherichia
coli) 		PF04386
(SspB) 		5 LEU A  65
VAL A  90
PHE A  72
LEU A  63
TYR A  18
 None
 1.43A 5cyqA-1ox8A:
undetectable		 5cyqA-1ox8A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 LEU A 286
VAL A  45
TYR A  12
PHE A 273
LEU A 272
 None
 1.27A 5cyqA-1up4A:
undetectable		 5cyqA-1up4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpx CARBOXYPEPTIDASE Y
INHIBITOR

(Saccharomyces
cerevisiae) 		PF01161
(PBP) 		5 PRO B 532
LEU B 708
VAL B 524
TYR B 515
TYR B 668
 None
 1.41A 5cyqA-1wpxB:
undetectable		 5cyqA-1wpxB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		5 LEU A 261
VAL A  34
VAL A  58
LEU A  22
TYR A 260
 None
 1.15A 5cyqA-1y9uA:
undetectable		 5cyqA-1y9uA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		5 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A 900 (-3.8A)
None
None
 1.20A 5cyqA-1z6tA:
undetectable		 5cyqA-1z6tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9l VESICLE-ASSOCIATED
MEMBRANE
PROTEIN-ASSOCIATED
PROTEIN A

(Rattus
norvegicus) 		PF00635
(Motile_Sperm) 		5 LEU A 119
VAL A  71
VAL A  44
TYR A  52
PHE A  18
 None
 1.40A 5cyqA-1z9lA:
undetectable		 5cyqA-1z9lA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5i CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		5 LEU C 140
VAL C 165
TYR C 197
TYR C 167
PHE C 186
 None
 1.48A 5cyqA-2b5iC:
undetectable		 5cyqA-2b5iC:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		5 LEU A  71
VAL A  46
PHE A  95
LEU A  98
TYR A 102
 None
 1.23A 5cyqA-2ch6A:
4.2		 5cyqA-2ch6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csw UBIQUITIN LIGASE
PROTEIN RNF8

(Homo sapiens) 		PF00498
(FHA) 		5 LEU A 108
VAL A  46
VAL A  65
TYR A  48
LEU A  50
 None
 1.44A 5cyqA-2cswA:
undetectable		 5cyqA-2cswA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e21 TRNA(ILE)-LYSIDINE
SYNTHASE

(Aquifex
aeolicus) 		PF01171
(ATP_bind_3) 		5 LEU A  40
VAL A  11
VAL A 172
PHE A  51
LEU A  44
 None
 1.41A 5cyqA-2e21A:
1.3		 5cyqA-2e21A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 PRO A 242
LEU A 240
VAL A 189
LEU A 300
TYR A 238
 None
 1.33A 5cyqA-2elcA:
undetectable		 5cyqA-2elcA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erj CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		5 LEU C 140
VAL C 165
TYR C 197
TYR C 167
PHE C 186
 None
 1.40A 5cyqA-2erjC:
undetectable		 5cyqA-2erjC:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
LYS A 103
VAL A 106
TYR A 181
TYR A 188
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.83A 5cyqA-2hnzA:
35.9		 5cyqA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
LYS A 103
VAL A 106
TYR A 188
PHE A 227
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.1A)
PC0  A 999 (-4.7A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.91A 5cyqA-2hnzA:
35.9		 5cyqA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
VAL A 106
VAL A 179
TYR A 181
TYR A 188
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.84A 5cyqA-2hnzA:
35.9		 5cyqA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
VAL A 106
VAL A 179
TYR A 188
PHE A 227
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-4.1A)
PC0  A 999 (-4.7A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.94A 5cyqA-2hnzA:
35.9		 5cyqA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		8 PRO A  95
LEU A 100
LYS A 103
VAL A 106
PHE A 227
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.7A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.72A 5cyqA-2hnzA:
35.9		 5cyqA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		8 PRO A  95
LEU A 100
LYS A 103
VAL A 106
TYR A 181
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.80A 5cyqA-2hnzA:
35.9		 5cyqA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		8 PRO A  95
LEU A 100
VAL A 106
VAL A 179
PHE A 227
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-4.7A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.76A 5cyqA-2hnzA:
35.9		 5cyqA-2hnzA:
98.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		8 PRO A  95
LEU A 100
VAL A 106
VAL A 179
TYR A 181
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.82A 5cyqA-2hnzA:
35.9		 5cyqA-2hnzA:
98.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkn UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF12850
(Metallophos_2) 		5 PRO A 132
LEU A 112
VAL A  58
PHE A   4
LEU A 143
 None
 1.34A 5cyqA-2kknA:
undetectable		 5cyqA-2kknA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv3 THIOREDOXIN
REDUCTASE 3

(Mus musculus) 		PF00462
(Glutaredoxin) 		5 LEU A 117
VAL A  63
VAL A  97
TYR A  65
LEU A  57
 None
 1.40A 5cyqA-2lv3A:
undetectable		 5cyqA-2lv3A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdp PUTATIVE
TRANSCRIPTIONAL
REGULATOR MARR

(Geobacillus
stearothermophilus) 		PF01047
(MarR) 		5 LEU A  82
LYS A 102
VAL A 110
PHE A  42
LEU A  45
 None
 1.44A 5cyqA-2rdpA:
undetectable		 5cyqA-2rdpA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 LEU A 387
VAL A 211
VAL A 129
PHE A 401
LEU A 407
 None
 1.40A 5cyqA-2vdaA:
undetectable		 5cyqA-2vdaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 PRO A  59
LEU A  85
VAL A  24
TRP A  49
LEU A  81
 None
 1.44A 5cyqA-2vw8A:
undetectable		 5cyqA-2vw8A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN

(Streptomyces
coelicolor) 		PF01497
(Peripla_BP_2) 		5 PRO A  69
LEU A 190
VAL A  78
VAL A  89
LEU A 186
 None
 1.40A 5cyqA-2x4lA:
undetectable		 5cyqA-2x4lA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8w METHYLGLYOXAL
SYNTHASE

(Thermus sp. GH5) 		PF02142
(MGS) 		5 PRO A 105
LEU A  74
VAL A  26
TRP A 119
LEU A 123
 None
 1.44A 5cyqA-2x8wA:
undetectable		 5cyqA-2x8wA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		5 LEU A  57
VAL A  23
VAL A  47
TRP A  38
LEU A  33
 None
 1.20A 5cyqA-2ybqA:
undetectable		 5cyqA-2ybqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		5 LEU A 130
VAL A 108
TYR A 103
PHE A  51
LEU A 114
 None
 1.29A 5cyqA-3futA:
undetectable		 5cyqA-3futA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		5 LEU A 203
VAL A 164
VAL A 380
LEU A 188
TYR A 204
 None
 1.45A 5cyqA-3k2kA:
undetectable		 5cyqA-3k2kA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		5 LEU A 240
LYS A 243
VAL A 251
TYR A 177
LEU A 211
 None
 1.26A 5cyqA-3k53A:
undetectable		 5cyqA-3k53A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN

(Namalycastis
sp. ST01) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PRO A 120
LEU A 122
VAL A 248
VAL A 302
TYR A 290
 None
 1.15A 5cyqA-3l2eA:
3.0		 5cyqA-3l2eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		5 PRO A  54
LEU A 340
LYS A 160
TYR A 153
TYR A 252
 None
 1.24A 5cyqA-3l7gA:
undetectable		 5cyqA-3l7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 LEU A  46
VAL A  85
VAL A  29
TRP A 122
LEU A 106
 None
None
GOL  A 563 ( 4.3A)
None
None
 1.38A 5cyqA-3rcnA:
undetectable		 5cyqA-3rcnA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		5 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A1250 (-3.4A)
None
None
 1.13A 5cyqA-3sfzA:
undetectable		 5cyqA-3sfzA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sng NUCLEASE

(Solanum
lycopersicum) 		PF02265
(S1-P1_nuclease) 		5 PRO A  55
LEU A  65
VAL A  72
PHE A 144
LEU A 143
 NAG  A 512 (-3.8A)
NAG  A 512 ( 4.3A)
None
None
None
 1.23A 5cyqA-3sngA:
undetectable		 5cyqA-3sngA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aej COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		PF01410
(COLFI) 		5 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.43A 5cyqA-4aejA:
undetectable		 5cyqA-4aejA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		5 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.45A 5cyqA-4by6A:
undetectable		 5cyqA-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		5 LEU A 447
VAL A 410
PHE A 422
LEU A 425
TYR A 443
 None
 1.50A 5cyqA-4eppA:
undetectable		 5cyqA-4eppA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PRO A  24
VAL A 148
VAL A  62
TYR A  22
LEU A 314
 None
 1.48A 5cyqA-4ewpA:
undetectable		 5cyqA-4ewpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 PRO A  77
LEU A  93
VAL A 405
PHE A 417
LEU A 416
 None
 1.46A 5cyqA-4fdhA:
undetectable		 5cyqA-4fdhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqn MALCAVERNIN

(Homo sapiens) 		PF16545
(CCM2_C) 		5 LEU A 338
TYR A 325
PHE A 356
LEU A 353
TYR A 342
 None
 1.46A 5cyqA-4fqnA:
undetectable		 5cyqA-4fqnA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdl AUTOPHAGY PROTEIN 5

(Homo sapiens) 		PF04106
(APG5) 		5 LEU B  45
VAL B 102
VAL B  52
TRP B  98
LEU B  77
 None
 1.23A 5cyqA-4gdlB:
undetectable		 5cyqA-4gdlB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens) 		no annotation 5 LEU A 376
VAL A 362
TYR A 352
PHE A 313
LEU A 297
 None
 1.41A 5cyqA-4gxbA:
undetectable		 5cyqA-4gxbA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raf PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		PF00481
(PP2C)
PF07830
(PP2C_C) 		5 PRO A 343
LEU A 345
VAL A 357
TYR A 311
LEU A 351
 None
 1.43A 5cyqA-4rafA:
undetectable		 5cyqA-4rafA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rml LATROPHILIN-3

(Mus musculus) 		PF02191
(OLF) 		5 LEU A 444
VAL A 423
VAL A 391
TYR A 389
LEU A 457
 None
 1.22A 5cyqA-4rmlA:
undetectable		 5cyqA-4rmlA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 PRO A 616
LYS A 433
VAL A 429
PHE A 576
LEU A 579
 None
 1.40A 5cyqA-4tptA:
undetectable		 5cyqA-4tptA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		5 LEU A 242
VAL A  89
VAL A  40
TYR A  97
TYR A 219
 None
 1.35A 5cyqA-4wcjA:
1.5		 5cyqA-4wcjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 139
VAL E 155
VAL E 125
TYR E  38
LEU E 143
 None
 1.33A 5cyqA-4xgcE:
undetectable		 5cyqA-4xgcE:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykc MALCAVERNIN

(Homo sapiens) 		PF16545
(CCM2_C) 		5 LEU A 338
TYR A 325
PHE A 356
LEU A 353
TYR A 342
 None
 1.48A 5cyqA-4ykcA:
undetectable		 5cyqA-4ykcA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 LEU A 243
TYR A 322
TYR A 319
PHE A 288
LEU A 291
 None
 1.32A 5cyqA-4zr0A:
undetectable		 5cyqA-4zr0A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 LEU A 243
TYR A 322
TYR A 319
PHE A 288
LEU A 291
 None
None
None
TRD  A 409 (-4.7A)
TRD  A 409 ( 4.4A)
 1.32A 5cyqA-4zr1A:
undetectable		 5cyqA-4zr1A:
18.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LYS B 103
VAL B 106
VAL B 179
TYR B 181
TYR B 188
 None
 0.75A 5cyqA-5c24B:
10.8		 5cyqA-5c24B:
96.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl6 PUTATIVE GAF SENSOR
PROTEIN

(Burkholderia
vietnamiensis) 		PF13185
(GAF_2) 		5 LEU A  19
VAL A 134
TYR A  45
LEU A  48
TYR A  16
 None
 1.27A 5cyqA-5hl6A:
undetectable		 5cyqA-5hl6A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		5 LEU A 387
VAL A 211
VAL A 129
PHE A 401
LEU A 407
 None
 1.50A 5cyqA-5k9tA:
undetectable		 5cyqA-5k9tA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 PRO A  90
LEU A  79
VAL A 189
PHE A 100
LEU A  97
 None
 1.48A 5cyqA-5o1mA:
undetectable		 5cyqA-5o1mA:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 6 PRO A  94
LEU A  99
LYS A 102
VAL A 105
LEU A 233
TYR A 317
 None
 0.98A 5cyqA-5ovnA:
25.3		 5cyqA-5ovnA:
53.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt7 PERIOSTIN

(Homo sapiens) 		no annotation 5 LEU A   7
VAL A 131
TYR A  73
PHE A  17
LEU A  11
 None
 1.42A 5cyqA-5wt7A:
undetectable		 5cyqA-5wt7A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		5 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
 1.24A 5cyqA-5wveA:
1.3		 5cyqA-5wveA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fzw COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		no annotation 5 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.36A 5cyqA-6fzwA:
undetectable		 5cyqA-6fzwA:
8.36