SIMILAR PATTERNS OF AMINO ACIDS FOR 5CXV_A_0HKA501_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a40 | PHOSPHATE-BINDINGPERIPLASMIC PROTEINPRECURSOR (Escherichiacoli) |
PF12849(PBP_like_2) | 3 | THR A 256THR A 255PHE A 224 | None | 0.81A | 5cxvA-1a40A:undetectable | 5cxvA-1a40A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ad9 | IGG CTM01 FAB (LIGHTCHAIN) (Homo sapiens) |
no annotation | 3 | THR L 102THR L 85PHE L 83 | None | 0.80A | 5cxvA-1ad9L:undetectable | 5cxvA-1ad9L:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1btc | BETA-AMYLASE (Glycine max) |
PF01373(Glyco_hydro_14) | 3 | THR A 253THR A 256PHE A 261 | None | 0.60A | 5cxvA-1btcA:undetectable | 5cxvA-1btcA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cee | GTP-BINDING RHO-LIKEPROTEINWISKOTT-ALDRICHSYNDROME PROTEINWASP (Homo sapiens) |
PF00071(Ras)PF00786(PBD) | 3 | THR A 52THR A 43PHE B 15 | None | 0.82A | 5cxvA-1ceeA:undetectable | 5cxvA-1ceeA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1crz | TOLB PROTEIN (Escherichiacoli) |
PF04052(TolB_N)PF07676(PD40) | 3 | THR A 366THR A 385PHE A 389 | None | 0.80A | 5cxvA-1crzA:undetectable | 5cxvA-1crzA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dm1 | MYOGLOBIN (Aplysialimacina) |
PF00042(Globin) | 3 | THR A 66THR A 69PHE A 74 | HEM A 148 (-4.5A)NoneNone | 0.91A | 5cxvA-1dm1A:0.0 | 5cxvA-1dm1A:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f4h | BETA-GALACTOSIDASE (Escherichiacoli) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 3 | THR A 104THR A 101PHE A 601 | None | 0.71A | 5cxvA-1f4hA:undetectable | 5cxvA-1f4hA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hfs | STROMELYSIN-1 (Homo sapiens) |
PF00413(Peptidase_M10) | 3 | THR A 193THR A 187PHE A 196 | None | 0.89A | 5cxvA-1hfsA:undetectable | 5cxvA-1hfsA:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ixk | METHYLTRANSFERASE (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 3 | THR A 198THR A 202PHE A 307 | None | 0.89A | 5cxvA-1ixkA:undetectable | 5cxvA-1ixkA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ogy | PERIPLASMIC NITRATEREDUCTASE (Rhodobactersphaeroides) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 3 | THR A 545THR A 544PHE A 566 | None | 0.91A | 5cxvA-1ogyA:undetectable | 5cxvA-1ogyA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sdd | COAGULATION FACTOR V (Bos taurus) |
PF00754(F5_F8_type_C)PF07732(Cu-oxidase_3) | 3 | THR B2005THR B1914PHE B1916 | None | 0.62A | 5cxvA-1sddB:undetectable | 5cxvA-1sddB:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t71 | PHOSPHATASE (Mycoplasmapneumoniae) |
PF13277(YmdB) | 3 | THR A 134THR A 135PHE A 138 | None | 0.84A | 5cxvA-1t71A:undetectable | 5cxvA-1t71A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tol | PROTEIN (FUSIONPROTEIN CONSISTINGOF MINOR COATPROTEIN, GLYCINERICH LINKER, TOLA,AND A HIS TAG) (Escherichiacoli;Escherichiavirus M13) |
PF05357(Phage_Coat_A)PF06519(TolA) | 3 | THR A 56THR A 41PHE A 211 | None | 0.80A | 5cxvA-1tolA:undetectable | 5cxvA-1tolA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z06 | RAS-RELATED PROTEINRAB-33B (Mus musculus) |
PF00071(Ras) | 3 | THR A 47THR A 50PHE A 70 | MG A 203 ( 3.0A)NoneNone | 0.85A | 5cxvA-1z06A:undetectable | 5cxvA-1z06A:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zh1 | NON-STRUCTURALPOLYPROTEIN (Hepacivirus C) |
PF08300(HCV_NS5a_1a)PF08301(HCV_NS5a_1b) | 3 | THR A 134THR A 135PHE A 175 | None | 0.92A | 5cxvA-1zh1A:undetectable | 5cxvA-1zh1A:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d86 | VAV-3 PROTEIN (Homo sapiens) |
PF11971(CAMSAP_CH) | 3 | THR A 84THR A 87PHE A 93 | None | 0.86A | 5cxvA-2d86A:undetectable | 5cxvA-2d86A:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ep7 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Aquifexaeolicus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 3 | THR A 209THR A 208PHE A 195 | None | 0.87A | 5cxvA-2ep7A:undetectable | 5cxvA-2ep7A:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f5a | PROTEIN (ANTIBODY2F5 (LIGHT CHAIN)) (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 3 | THR L 102THR L 85PHE L 83 | None | 0.87A | 5cxvA-2f5aL:undetectable | 5cxvA-2f5aL:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ghi | TRANSPORT PROTEIN (Plasmodiumyoelii) |
PF00005(ABC_tran) | 3 | THR A 47THR A 206PHE A 14 | None | 0.80A | 5cxvA-2ghiA:undetectable | 5cxvA-2ghiA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hmf | PROBABLEASPARTOKINASE (Methanocaldococcusjannaschii) |
PF00696(AA_kinase)PF01842(ACT)PF13840(ACT_7) | 3 | THR A 238THR A 237PHE A 467 | None | 0.87A | 5cxvA-2hmfA:undetectable | 5cxvA-2hmfA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m07 | OUTER MEMBRANEPROTEIN X (Escherichiacoli) |
PF13505(OMP_b-brl) | 3 | THR A 93THR A 92PHE A 90 | None | 0.91A | 5cxvA-2m07A:undetectable | 5cxvA-2m07A:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pbe | AMINOGLYCOSIDE6-ADENYLYLTRANSFERASE (Bacillussubtilis) |
PF04439(Adenyl_transf) | 3 | THR A 230THR A 245PHE A 250 | None | 0.63A | 5cxvA-2pbeA:undetectable | 5cxvA-2pbeA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pql | D7R4 PROTEIN (Anophelesgambiae) |
PF01395(PBP_GOBP) | 3 | THR A 102THR A 105PHE A 110 | NoneNoneTSS A 145 (-4.4A) | 0.84A | 5cxvA-2pqlA:undetectable | 5cxvA-2pqlA:14.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1f | CHONDROITINASE (Bacteroidesthetaiotaomicron) |
PF02278(Lyase_8)PF09092(Lyase_N)PF09093(Lyase_catalyt) | 3 | THR A 908THR A 895PHE A 893 | None | 0.91A | 5cxvA-2q1fA:undetectable | 5cxvA-2q1fA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1f | CHONDROITINASE (Bacteroidesthetaiotaomicron) |
PF02278(Lyase_8)PF09092(Lyase_N)PF09093(Lyase_catalyt) | 3 | THR A 910THR A 895PHE A 893 | None | 0.55A | 5cxvA-2q1fA:undetectable | 5cxvA-2q1fA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q83 | YTAA PROTEIN (Bacillussubtilis) |
PF01636(APH) | 3 | THR A 242THR A 245PHE A 139 | None | 0.90A | 5cxvA-2q83A:undetectable | 5cxvA-2q83A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qn0 | NEUROTOXIN (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 3 | THR A 126THR A 309PHE A 315 | None | 0.91A | 5cxvA-2qn0A:undetectable | 5cxvA-2qn0A:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rbc | SUGAR KINASE (Agrobacteriumfabrum) |
PF00294(PfkB) | 3 | THR A 20THR A 102PHE A 116 | EDO A 328 (-3.5A)EDO A 328 (-3.4A)None | 0.89A | 5cxvA-2rbcA:undetectable | 5cxvA-2rbcA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rgh | ALPHA-GLYCEROPHOSPHATE OXIDASE (Streptococcussp.) |
PF01266(DAO)PF16901(DAO_C) | 3 | THR A 299THR A 298PHE A 296 | NoneFAD A 609 (-3.9A)None | 0.78A | 5cxvA-2rghA:undetectable | 5cxvA-2rghA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v6j | RNA HELICASE (Kokobera virus) |
PF00271(Helicase_C)PF07652(Flavi_DEAD) | 3 | THR A 133THR A 131PHE A 104 | None | 0.83A | 5cxvA-2v6jA:undetectable | 5cxvA-2v6jA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v8o | FLAVIVIRIN PROTEASENS3 (Murray Valleyencephalitisvirus) |
PF00271(Helicase_C)PF07652(Flavi_DEAD) | 3 | THR A 318THR A 316PHE A 289 | None | 0.82A | 5cxvA-2v8oA:undetectable | 5cxvA-2v8oA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdt | LEVANSUCRASE (Bacillussubtilis) |
PF02435(Glyco_hydro_68) | 3 | THR A 194THR A 193PHE A 218 | None | 0.88A | 5cxvA-2vdtA:undetectable | 5cxvA-2vdtA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wv9 | FLAVIVIRIN PROTEASENS2B REGULATORYSUBUNIT, FLAVIVIRINPROTEASE NS3CATALYTIC SUBUNIT (Murray Valleyencephalitisvirus) |
PF00271(Helicase_C)PF00949(Peptidase_S7)PF01002(Flavi_NS2B)PF07652(Flavi_DEAD) | 3 | THR A 318THR A 316PHE A 289 | None | 0.84A | 5cxvA-2wv9A:undetectable | 5cxvA-2wv9A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x3l | ORN/LYS/ARGDECARBOXYLASE FAMILYPROTEIN (Staphylococcusaureus) |
PF01276(OKR_DC_1)PF03711(OKR_DC_1_C) | 3 | THR A 30THR A 339PHE A 342 | None | 0.90A | 5cxvA-2x3lA:undetectable | 5cxvA-2x3lA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x75 | ADENYLOSUCCINATELYASE (Staphylococcusaureus) |
PF00206(Lyase_1)PF10397(ADSL_C) | 3 | THR A 385THR A 387PHE A 389 | None | 0.92A | 5cxvA-2x75A:1.2 | 5cxvA-2x75A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ybu | ACIDIC MAMMALIANCHITINASE (Homo sapiens) |
PF00704(Glyco_hydro_18) | 3 | THR A 118THR A 121PHE A 126 | None | 0.71A | 5cxvA-2ybuA:undetectable | 5cxvA-2ybuA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yy5 | TRYPTOPHANYL-TRNASYNTHETASE (Mycoplasmapneumoniae) |
PF00579(tRNA-synt_1b) | 3 | THR A 326THR A 329PHE A 334 | None | 0.91A | 5cxvA-2yy5A:undetectable | 5cxvA-2yy5A:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z22 | PERIPLASMICPHOSPHATE-BINDINGPROTEIN (Yersinia pestis) |
no annotation | 3 | THR X 256THR X 255PHE X 224 | None | 0.82A | 5cxvA-2z22X:undetectable | 5cxvA-2z22X:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7m | CELLULASE (Rhodothermusmarinus) |
PF01670(Glyco_hydro_12) | 3 | THR A 13THR A 20PHE A 64 | None | 0.87A | 5cxvA-3b7mA:undetectable | 5cxvA-3b7mA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ho6 | TOXIN A (Clostridioidesdifficile) |
PF11713(Peptidase_C80) | 3 | THR A 170THR A 120PHE A 123 | None | 0.83A | 5cxvA-3ho6A:undetectable | 5cxvA-3ho6A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hvs | THIOL PEROXIDASE (Escherichiacoli) |
PF08534(Redoxin) | 3 | THR A 73THR A 78PHE A 43 | None | 0.89A | 5cxvA-3hvsA:undetectable | 5cxvA-3hvsA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iv6 | PUTATIVEZN-DEPENDENT ALCOHOLDEHYDROGENASE (Rhodobactersphaeroides) |
no annotation | 3 | THR A 122THR A 121PHE A 177 | None | 0.87A | 5cxvA-3iv6A:undetectable | 5cxvA-3iv6A:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jst | PUTATIVEPTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE (Brucellamelitensis) |
PF01329(Pterin_4a) | 3 | THR A 31THR A 72PHE A 63 | EDO A 98 ( 4.8A)EDO A 98 (-3.9A)None | 0.85A | 5cxvA-3jstA:undetectable | 5cxvA-3jstA:10.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nnk | UREIDOGLYCINE-GLYOXYLATEAMINOTRANSFERASE (Klebsiellapneumoniae) |
PF00266(Aminotran_5) | 3 | THR A 173THR A 144PHE A 99 | NoneNoneLLP A 200 ( 3.7A) | 0.82A | 5cxvA-3nnkA:undetectable | 5cxvA-3nnkA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pa8 | TOXIN B (Clostridioidesdifficile) |
PF11713(Peptidase_C80) | 3 | THR A 167THR A 117PHE A 120 | None | 0.79A | 5cxvA-3pa8A:undetectable | 5cxvA-3pa8A:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3poy | NEUREXIN-1-ALPHA (Bos taurus) |
PF00008(EGF)PF02210(Laminin_G_2) | 3 | THR A 760THR A 652PHE A 650 | None | 0.63A | 5cxvA-3poyA:undetectable | 5cxvA-3poyA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qyq | DEOXYRIBOSE-PHOSPHATE ALDOLASE, PUTATIVE (Toxoplasmagondii) |
no annotation | 3 | THR A 11THR A 14PHE A 19 | None | 0.62A | 5cxvA-3qyqA:undetectable | 5cxvA-3qyqA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s99 | BASIC MEMBRANELIPOPROTEIN (Brucellaabortus) |
PF02608(Bmp) | 3 | THR A 86THR A 87PHE A 89 | None | 0.90A | 5cxvA-3s99A:undetectable | 5cxvA-3s99A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t5o | COMPLEMENT COMPONENTC6 (Homo sapiens) |
PF00057(Ldl_recept_a)PF00084(Sushi)PF00090(TSP_1)PF01823(MACPF) | 3 | THR A 693THR A 710PHE A 715 | None | 0.74A | 5cxvA-3t5oA:undetectable | 5cxvA-3t5oA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tva | XYLOSE ISOMERASEDOMAIN PROTEIN TIMBARREL (Planctopiruslimnophila) |
PF01261(AP_endonuc_2) | 3 | THR A 82THR A 85PHE A 71 | None | 0.80A | 5cxvA-3tvaA:undetectable | 5cxvA-3tvaA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u44 | ATP-DEPENDENTHELICASE/DEOXYRIBONUCLEASE SUBUNIT B (Bacillussubtilis) |
PF12705(PDDEXK_1) | 3 | THR B 236THR B 255PHE B 210 | None | 0.70A | 5cxvA-3u44B:undetectable | 5cxvA-3u44B:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ufa | SERINE PROTEASE SPLA (Staphylococcusaureus) |
PF00089(Trypsin) | 3 | THR A 141THR A 187PHE A 193 | None | 0.79A | 5cxvA-3ufaA:undetectable | 5cxvA-3ufaA:17.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uon | HUMAN M2 MUSCARINICACETYLCHOLINE,RECEPTOR T4 LYSOZYMEFUSION PROTEIN (Escherichiavirus T4;Homo sapiens) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | THR A 187THR A 190PHE A 195 | QNB A1162 (-4.8A)QNB A1162 (-4.3A)QNB A1162 (-4.4A) | 0.51A | 5cxvA-3uonA:39.7 | 5cxvA-3uonA:68.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vzm | ENDO-1,4-BETA-XYLANASE (Bacilluscirculans) |
PF00457(Glyco_hydro_11) | 3 | THR A 145THR A 50PHE A 48 | None | 0.86A | 5cxvA-3vzmA:undetectable | 5cxvA-3vzmA:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfl | BETA-MANNANASE (Talaromycestrachyspermus) |
PF00150(Cellulase) | 3 | THR A 39THR A 45PHE A 36 | None | 0.80A | 5cxvA-3wflA:undetectable | 5cxvA-3wflA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wv4 | NON-RIBOSOMALPEPTIDE SYNTHETASE (Streptomyceshalstedii) |
PF00501(AMP-binding) | 3 | THR A 292THR A 267PHE A 222 | None | 0.92A | 5cxvA-3wv4A:undetectable | 5cxvA-3wv4A:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zlc | ER-DERIVED VESICLESPROTEIN ERV41 (Saccharomycescerevisiae) |
PF07970(COPIIcoated_ERV)PF13850(ERGIC_N) | 3 | THR A 243THR A 254PHE A 208 | None | 0.84A | 5cxvA-3zlcA:undetectable | 5cxvA-3zlcA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zs6 | PERIPLASMICOLIGOPEPTIDE-BINDINGPROTEIN (Burkholderiapseudomallei) |
PF00496(SBP_bac_5) | 3 | THR A 339THR A 343PHE A 289 | None | 0.66A | 5cxvA-3zs6A:undetectable | 5cxvA-3zs6A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cgt | CYCLODEXTRINGLYCOSYLTRANSFERASE (Bacilluscirculans) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 3 | THR A 95THR A 86PHE A 84 | None | 0.75A | 5cxvA-4cgtA:undetectable | 5cxvA-4cgtA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4c | MULTIDRUG RESISTANCEPROTEIN PGP-1 (Caenorhabditiselegans) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 3 | THR A1045THR A 738PHE A 741 | None | 0.91A | 5cxvA-4f4cA:2.8 | 5cxvA-4f4cA:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f92 | U5 SMALL NUCLEARRIBONUCLEOPROTEIN200 KDA HELICASE (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 3 | THR B 583THR B 565PHE B 555 | None | 0.68A | 5cxvA-4f92B:undetectable | 5cxvA-4f92B:14.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gqz | PUTATIVE PERIPLASMICOR EXPORTED PROTEIN (Salmonellaenterica) |
no annotation | 3 | THR A 61THR A 171PHE A 97 | None | 0.73A | 5cxvA-4gqzA:undetectable | 5cxvA-4gqzA:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h8n | CONJUGATEDPOLYKETONE REDUCTASEC2 (Candidaparapsilosis) |
PF00248(Aldo_ket_red) | 3 | THR A 261THR A 260PHE A 214 | NDP A3001 (-4.0A)NDP A3001 (-3.4A)NDP A3001 (-3.2A) | 0.82A | 5cxvA-4h8nA:undetectable | 5cxvA-4h8nA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3h | TOPOISOMERASE IVSUBUNIT B, DNATOPOISOMERASE 4SUBUNIT A CHIMERA (Streptococcuspneumoniae) |
PF00204(DNA_gyraseB)PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim)PF02518(HATPase_c) | 3 | THR A1168THR A1176PHE A1327 | None | 0.85A | 5cxvA-4i3hA:undetectable | 5cxvA-4i3hA:18.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpn | NUCLEOSIDEN-RIBOHYDROLASE 1 (Physcomitrellapatens) |
PF01156(IU_nuc_hydro) | 3 | THR A 49THR A 50PHE A 82 | None | 0.91A | 5cxvA-4kpnA:undetectable | 5cxvA-4kpnA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ld7 | DIMETHYLALLYLTRYPTOPHAN SYNTHASE (Aspergillusfischeri) |
PF11991(Trp_DMAT) | 3 | THR A 404THR A 406PHE A 427 | None | 0.88A | 5cxvA-4ld7A:undetectable | 5cxvA-4ld7A:22.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4mqt | MUSCARINICACETYLCHOLINERECEPTOR M2 (Homo sapiens) |
PF00001(7tm_1) | 3 | THR A 187THR A 190PHE A 195 | None | 0.49A | 5cxvA-4mqtA:32.6 | 5cxvA-4mqtA:41.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 3 | THR A 579THR A 428PHE A 199 | None | 0.86A | 5cxvA-4ph9A:undetectable | 5cxvA-4ph9A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pka | PATATIN-17 (Solanumcardiophyllum) |
PF01734(Patatin) | 3 | THR X 76THR X 187PHE X 155 | MIS X 77 ( 3.8A)MIS X 77 ( 3.0A)None | 0.76A | 5cxvA-4pkaX:undetectable | 5cxvA-4pkaX:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pu5 | TOXIN-ANTITOXINSYSTEM TOXIN HIPAFAMILY (Shewanellaoneidensis) |
PF07804(HipA_C)PF13657(Couple_hipA) | 3 | THR A 3THR A 6PHE A 23 | None | 0.90A | 5cxvA-4pu5A:undetectable | 5cxvA-4pu5A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qqr | 3,5-EPIMERASE/4-REDUCTASE (Arabidopsisthaliana) |
PF04321(RmlD_sub_bind) | 3 | THR A 222THR A 198PHE A 180 | None | 0.80A | 5cxvA-4qqrA:undetectable | 5cxvA-4qqrA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4txw | HYALURONOGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C) | 3 | THR A 57THR A 96PHE A 94 | None | 0.70A | 5cxvA-4txwA:undetectable | 5cxvA-4txwA:16.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4u14 | MUSCARINICACETYLCHOLINERECEPTORM3,ENDOLYSIN,MUSCARINIC ACETYLCHOLINERECEPTOR M3 (Escherichiavirus T4;Rattusnorvegicus) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | THR A 231THR A 234PHE A 239 | 0HK A2000 (-4.3A)NoneNone | 0.52A | 5cxvA-4u14A:42.6 | 5cxvA-4u14A:73.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4u16 | MUSCARINICACETYLCHOLINERECEPTORM3,LYSOZYME,MUSCARINIC ACETYLCHOLINERECEPTOR M3 (Escherichiavirus T4;Rattusnorvegicus) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | THR A 231THR A 234PHE A 239 | None | 0.51A | 5cxvA-4u16A:39.2 | 5cxvA-4u16A:67.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u5a | SPOROZOITE MICRONEMEPROTEIN ESSENTIALFOR CELL TRAVERSAL (Plasmodiumberghei) |
no annotation | 3 | THR A 68THR A 71PHE A 76 | None | 0.85A | 5cxvA-4u5aA:3.4 | 5cxvA-4u5aA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8o | LUCIFERASE-LIKEENZYMEAMP-COA-LIGASE (Zophobasatratus) |
PF00501(AMP-binding) | 3 | THR A 78THR A 224PHE A 222 | None | 0.57A | 5cxvA-4w8oA:undetectable | 5cxvA-4w8oA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x81 | MYCINAMICIN III3''-O-METHYLTRANSFERASE (Micromonosporagriseorubida) |
PF05711(TylF) | 3 | THR A 145THR A 149PHE A 154 | None | 0.92A | 5cxvA-4x81A:undetectable | 5cxvA-4x81A:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xyd | NORC-LIKE PROTEIN (Roseobacterdenitrificans) |
PF00034(Cytochrom_C) | 3 | THR B 45THR B 47PHE B 132 | None | 0.75A | 5cxvA-4xydB:undetectable | 5cxvA-4xydB:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ao5 | C-TYPE MANNOSERECEPTOR 2 (Homo sapiens) |
PF00040(fn2)PF00059(Lectin_C) | 3 | THR A 216THR A 188PHE A 198 | SO4 A1512 (-4.1A)SO4 A1512 ( 4.0A)None | 0.64A | 5cxvA-5ao5A:undetectable | 5cxvA-5ao5A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bs5 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 3 | THR A 733THR A 736PHE A 738 | None | 0.89A | 5cxvA-5bs5A:undetectable | 5cxvA-5bs5A:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bz0 | REPLICASEPOLYPROTEIN 1AB (Aviancoronavirus) |
PF08715(Viral_protease) | 3 | THR A 291THR A 202PHE A 207 | None | 0.91A | 5cxvA-5bz0A:undetectable | 5cxvA-5bz0A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5djq | CBB3-TYPE CYTOCHROMEC OXIDASE SUBUNITCCOP1 (Pseudomonasstutzeri) |
PF13442(Cytochrome_CBB3)PF14715(FixP_N) | 3 | THR C 13THR C 16PHE C 21 | None | 0.81A | 5cxvA-5djqC:undetectable | 5cxvA-5djqC:20.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5dsg | MUSCARINICACETYLCHOLINERECEPTORM4,ENDOLYSIN,ENDOLYSIN,MUSCARINICACETYLCHOLINERECEPTOR M4 (Escherichiavirus T4;Homo sapiens) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | THR A 196THR A 199PHE A 204 | P6G A1205 (-4.6A)OLC A1208 (-4.4A)None | 0.42A | 5cxvA-5dsgA:42.1 | 5cxvA-5dsgA:61.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ep8 | PYRIMIDINE-NUCLEOSIDE PHOSPHORYLASE (Bacillussubtilis) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 3 | THR A 210THR A 202PHE A 207 | THR A 210 ( 0.8A)THR A 202 ( 0.8A)PHE A 207 ( 1.3A) | 0.83A | 5cxvA-5ep8A:undetectable | 5cxvA-5ep8A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f0g | GLUTATHIONES-TRANSFERASE D2 (Drosophilamelanogaster) |
PF00043(GST_C)PF02798(GST_N) | 3 | THR A 162THR A 165PHE A 171 | None | 0.68A | 5cxvA-5f0gA:undetectable | 5cxvA-5f0gA:17.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fp2 | FERRIC ENTEROBACTINRECEPTOR PIRA (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 3 | THR A 452THR A 458PHE A 519 | None | 0.75A | 5cxvA-5fp2A:undetectable | 5cxvA-5fp2A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsa | CYP51 VARIANT1 (Candidaalbicans) |
PF00067(p450) | 3 | THR A 196THR A 199PHE A 205 | None | 0.86A | 5cxvA-5fsaA:undetectable | 5cxvA-5fsaA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h42 | UNCHARACTERIZEDPROTEIN (Lachnoclostridiumphytofermentans) |
PF17167(Glyco_hydro_36) | 3 | THR A1052THR A1047PHE A 583 | None | 0.92A | 5cxvA-5h42A:undetectable | 5cxvA-5h42A:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzh | RAS-RELATED C3BOTULINUM TOXINSUBSTRATE1,NPH1-1,RAS-RELATEDC3 BOTULINUM TOXINSUBSTRATE 1 (Avena sativa;Homo sapiens) |
PF00071(Ras)PF13426(PAS_9) | 3 | THR A 24THR A 25PHE A 28 | NoneNoneGTP A 401 (-4.8A) | 0.89A | 5cxvA-5hzhA:undetectable | 5cxvA-5hzhA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 3 | THR A 578THR A 427PHE A 198 | None | 0.85A | 5cxvA-5ikrA:undetectable | 5cxvA-5ikrA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikz | OXALATE BIOSYNTHETICCOMPONENT 1 (Burkholderiathailandensis) |
PF05853(BKACE) | 3 | THR A1038THR A1054PHE A1057 | None | 0.92A | 5cxvA-5ikzA:undetectable | 5cxvA-5ikzA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ir6 | BD-TYPE QUINOLOXIDASE SUBUNIT I (Geobacillusstearothermophilus) |
PF01654(Cyt_bd_oxida_I) | 3 | THR A 303THR A 262PHE A 260 | None | 0.53A | 5cxvA-5ir6A:2.7 | 5cxvA-5ir6A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1r | BURKHOLDERIAPSEUDOMALLEISPHINGOSINE-1-PHOSPHATE LYASE BPSS2021 (Burkholderiapseudomallei) |
PF00282(Pyridoxal_deC) | 3 | THR A 409THR A 344PHE A 366 | None | 0.75A | 5cxvA-5k1rA:undetectable | 5cxvA-5k1rA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5txr | 5-AMINOLEVULINATESYNTHASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
no annotation | 3 | THR B 368THR B 367PHE B 365 | None | 0.92A | 5cxvA-5txrB:undetectable | 5cxvA-5txrB:9.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubc | PROTEIN TOC75-3,CHLOROPLASTIC (Arabidopsisthaliana) |
no annotation | 3 | THR A 215THR A 218PHE A 349 | None | 0.61A | 5cxvA-5ubcA:undetectable | 5cxvA-5ubcA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xk8 | UNDECAPRENYLDIPHOSPHATE SYNTHASE (Streptomycessp. CNH189) |
no annotation | 3 | THR A 2THR A 46PHE A 48 | None | 0.85A | 5cxvA-5xk8A:undetectable | 5cxvA-5xk8A:9.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xsy | SODIUM CHANNELPROTEIN (Electrophoruselectricus) |
PF00520(Ion_trans)PF06512(Na_trans_assoc) | 3 | THR A 992THR A 995PHE A1002 | None | 0.91A | 5cxvA-5xsyA:undetectable | 5cxvA-5xsyA:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c6l | V-TYPE PROTON ATPASESUBUNIT A, VACUOLARISOFORM (Saccharomycescerevisiae) |
no annotation | 3 | THR A 411THR A 414PHE A 419 | None | 0.60A | 5cxvA-6c6lA:undetectable | 5cxvA-6c6lA:8.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6co9 | PROBABLECOA-TRANSFERASE BETASUBUNIT (Rhodococcusjostii) |
no annotation | 3 | THR B 47THR B 48PHE B 22 | None | 0.84A | 5cxvA-6co9B:undetectable | 5cxvA-6co9B:12.30 |