SIMILAR PATTERNS OF AMINO ACIDS FOR 5CXV_A_0HKA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642

(Pyrococcus
horikoshii) 		PF00795
(CN_hydrolase) 		5 ASP A 148
SER A 154
ALA A 163
ALA A 159
TYR A 111
 None
 1.37A 5cxvA-1j31A:
undetectable		 5cxvA-1j31A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		5 ASP A 341
ALA A 424
ALA A 311
TYR A   5
TYR A   3
 None
 1.42A 5cxvA-1ks8A:
0.0		 5cxvA-1ks8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		5 SER A 115
GLN A 116
ALA A 142
TYR A 225
ASN A 194
 PLP  A 418 (-3.7A)
None
None
PLP  A 418 (-4.3A)
PLP  A 418 (-3.7A)
 1.42A 5cxvA-1wstA:
undetectable		 5cxvA-1wstA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bod ENDOGLUCANASE E-2

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		5 ASP X  99
TRP X  97
ALA X  75
ALA X  88
TYR X 139
 None
 1.40A 5cxvA-2bodX:
undetectable		 5cxvA-2bodX:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf0 BILE SALT HYDROLASE

(Bifidobacterium
longum) 		PF02275
(CBAH) 		5 TYR A  14
GLN A 239
ALA A 243
ALA A 244
TYR A 287
 None
 1.49A 5cxvA-2hf0A:
undetectable		 5cxvA-2hf0A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		5 ASP A 102
TYR A  99
TRP A 123
ALA A 116
ALA A 120
 None
 1.43A 5cxvA-2iyfA:
undetectable		 5cxvA-2iyfA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		5 SER A 129
GLN A 130
ALA A 156
TYR A 239
ASN A 208
 PLP  A 429 (-3.8A)
None
None
PLP  A 429 (-4.4A)
PLP  A 429 (-3.7A)
 1.44A 5cxvA-3aovA:
0.0		 5cxvA-3aovA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxp PUTATIVE
LIPASE/ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		5 GLN A  73
TRP A  84
ALA A  12
ASN A   9
TYR A 143
 None
EPE  A 277 (-3.9A)
None
None
None
 1.39A 5cxvA-3bxpA:
undetectable		 5cxvA-3bxpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASP A 622
SER A 625
GLN A 627
ALA A 679
TYR A 687
 None
 1.39A 5cxvA-3fawA:
undetectable		 5cxvA-3fawA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzq PUTATIVE HYDROLASE

(Clostridioides
difficile) 		PF08282
(Hydrolase_3) 		5 ASP A 185
TYR A 190
SER A 188
ALA A 116
ALA A 101
 None
 1.18A 5cxvA-3fzqA:
undetectable		 5cxvA-3fzqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane)
PF03598
(CdhC) 		5 ASP A 226
SER M  34
ALA M 102
ALA M 105
TYR M  26
 None
 1.39A 5cxvA-3i04A:
0.5		 5cxvA-3i04A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0z PUTATIVE POLYKETIDE
CYCLASE

(Bacillus cereus) 		PF07366
(SnoaL) 		5 ASP A 147
ALA A 102
ALA A 101
TYR A  63
CYH A 114
 None
None
NHE  A   1 (-3.4A)
None
None
 1.48A 5cxvA-3k0zA:
undetectable		 5cxvA-3k0zA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)

(Pyrococcus
abyssi) 		PF00795
(CN_hydrolase) 		5 ASP A 148
SER A 154
ALA A 163
ALA A 159
TYR A 111
 None
 1.37A 5cxvA-3ki8A:
undetectable		 5cxvA-3ki8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		5 GLN A 348
ALA A 193
ALA A 196
TYR A 121
TYR A 125
 None
 1.50A 5cxvA-3mx3A:
1.3		 5cxvA-3mx3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 ASP A 737
SER A 867
ALA A 611
ALA A 610
TYR A 732
 None
 1.38A 5cxvA-3o8oA:
undetectable		 5cxvA-3o8oA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 107
TYR A 108
SER A 111
TRP A 158
ALA A 195
TRP A 428
 5EH  A1200 ( 2.6A)
D7V  A1201 ( 3.7A)
5EH  A1200 ( 3.7A)
5EH  A1200 ( 4.4A)
D7V  A1201 ( 4.7A)
5EH  A1200 ( 3.4A)
 1.16A 5cxvA-3rzeA:
23.4		 5cxvA-3rzeA:
55.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		5 ASP A 284
SER A 235
GLN A 233
ALA A 262
ALA A 263
 None
 1.38A 5cxvA-3tc8A:
undetectable		 5cxvA-3tc8A:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A 103
TYR A 104
ALA A 191
TYR A 426
CYH A 429
 QNB  A1162 (-3.1A)
QNB  A1162 (-4.0A)
QNB  A1162 (-3.9A)
QNB  A1162 ( 4.2A)
QNB  A1162 ( 4.0A)
 1.40A 5cxvA-3uonA:
39.7		 5cxvA-3uonA:
68.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 ASP A 103
TYR A 104
SER A 107
TRP A 155
ALA A 191
ALA A 194
TRP A 400
TYR A 403
ASN A 404
TYR A 426
CYH A 429
 QNB  A1162 (-3.1A)
QNB  A1162 (-4.0A)
QNB  A1162 (-3.4A)
QNB  A1162 (-4.2A)
QNB  A1162 (-3.9A)
QNB  A1162 ( 4.0A)
QNB  A1162 (-4.7A)
QNB  A1162 (-3.9A)
QNB  A1162 (-2.9A)
QNB  A1162 ( 4.2A)
QNB  A1162 ( 4.0A)
 0.74A 5cxvA-3uonA:
39.7		 5cxvA-3uonA:
68.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE

(Agrobacterium
fabrum) 		PF13407
(Peripla_BP_4) 		5 ASP A 213
TYR A 212
SER A 216
ALA A 186
ALA A 188
 None
BDP  A 331 (-3.2A)
None
None
None
 1.29A 5cxvA-3uugA:
undetectable		 5cxvA-3uugA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		5 TYR A 471
SER A 470
ALA A 498
TRP A 315
ASN A 289
 None
 1.37A 5cxvA-4ia5A:
undetectable		 5cxvA-4ia5A:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		8 ASP A 103
TYR A 104
SER A 107
ALA A 191
ALA A 194
ASN A 404
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.4A)
None
IXO  A 501 (-3.5A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 0.79A 5cxvA-4mqtA:
32.6		 5cxvA-4mqtA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		7 ASP A 103
TYR A 104
SER A 107
ALA A 191
TRP A 400
ASN A 404
TYR A 426
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.4A)
None
IXO  A 501 (-4.6A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
 0.90A 5cxvA-4mqtA:
32.6		 5cxvA-4mqtA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		7 ASP A 103
TYR A 104
SER A 107
TRP A 155
ALA A 194
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.4A)
IXO  A 501 (-3.6A)
IXO  A 501 (-3.5A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 0.75A 5cxvA-4mqtA:
32.6		 5cxvA-4mqtA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
TYR A 104
SER A 107
TRP A 155
TRP A 400
TYR A 426
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.4A)
IXO  A 501 (-3.6A)
IXO  A 501 (-4.6A)
2CU  A 502 ( 3.9A)
 0.93A 5cxvA-4mqtA:
32.6		 5cxvA-4mqtA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		6 ASP A 103
TYR A 104
TRP A 155
ALA A 191
TYR A 426
CYH A 429
 IXO  A 501 (-3.4A)
IXO  A 501 (-3.7A)
IXO  A 501 (-3.6A)
None
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 1.36A 5cxvA-4mqtA:
32.6		 5cxvA-4mqtA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		7 TYR A 104
SER A 107
ALA A 191
TRP A 400
TYR A 403
ASN A 404
TYR A 426
 IXO  A 501 (-3.7A)
IXO  A 501 (-3.4A)
None
IXO  A 501 (-4.6A)
IXO  A 501 (-3.8A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
 1.07A 5cxvA-4mqtA:
32.6		 5cxvA-4mqtA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		7 TYR A 104
SER A 107
ALA A 191
TYR A 403
ASN A 404
TYR A 426
CYH A 429
 IXO  A 501 (-3.7A)
IXO  A 501 (-3.4A)
None
IXO  A 501 (-3.8A)
IXO  A 501 (-3.0A)
2CU  A 502 ( 3.9A)
IXO  A 501 (-3.5A)
 0.90A 5cxvA-4mqtA:
32.6		 5cxvA-4mqtA:
41.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qni UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		5 ASP A 249
TYR A 247
TYR A 328
ASN A 202
TYR A 318
 None
None
None
EDO  A 403 ( 4.9A)
None
 1.46A 5cxvA-4qniA:
undetectable		 5cxvA-4qniA:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A 147
TYR A 148
ALA A 235
TYR A 529
CYH A 532
 0HK  A2000 (-3.2A)
0HK  A2000 (-2.8A)
0HK  A2000 ( 3.9A)
0HK  A2000 (-4.1A)
0HK  A2000 (-3.9A)
 1.31A 5cxvA-4u14A:
42.6		 5cxvA-4u14A:
73.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 ASP A 147
TYR A 148
SER A 151
ALA A 235
ALA A 238
TRP A 503
TYR A 506
ASN A 507
TYR A 529
CYH A 532
 0HK  A2000 (-3.2A)
0HK  A2000 (-2.8A)
0HK  A2000 (-3.3A)
0HK  A2000 ( 3.9A)
0HK  A2000 ( 3.8A)
0HK  A2000 (-4.3A)
0HK  A2000 (-4.1A)
0HK  A2000 (-2.9A)
0HK  A2000 (-4.1A)
0HK  A2000 (-3.9A)
 0.61A 5cxvA-4u14A:
42.6		 5cxvA-4u14A:
73.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 ASP A 147
TYR A 148
TRP A 199
ALA A 235
ALA A 238
TRP A 503
TYR A 506
ASN A 507
TYR A 529
CYH A 532
 0HK  A2000 (-3.2A)
0HK  A2000 (-2.8A)
0HK  A2000 (-4.5A)
0HK  A2000 ( 3.9A)
0HK  A2000 ( 3.8A)
0HK  A2000 (-4.3A)
0HK  A2000 (-4.1A)
0HK  A2000 (-2.9A)
0HK  A2000 (-4.1A)
0HK  A2000 (-3.9A)
 0.47A 5cxvA-4u14A:
42.6		 5cxvA-4u14A:
73.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 ASP A 147
TYR A 148
SER A 151
ALA A 235
ALA A 238
TRP A 503
TYR A 506
ASN A 507
TYR A 529
CYH A 532
 3C0  A1202 (-3.4A)
3C0  A1202 (-3.7A)
3C0  A1202 (-2.9A)
3C0  A1202 (-3.5A)
3C0  A1202 (-3.5A)
3C0  A1202 ( 4.0A)
3C0  A1202 (-3.7A)
3C0  A1202 (-2.9A)
3C0  A1202 (-3.7A)
3C0  A1202 (-3.6A)
 0.58A 5cxvA-4u16A:
39.2		 5cxvA-4u16A:
67.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 ASP A 147
TYR A 148
SER A 151
TRP A 199
ALA A 235
TRP A 503
TYR A 506
ASN A 507
TYR A 529
CYH A 532
 3C0  A1202 (-3.4A)
3C0  A1202 (-3.7A)
3C0  A1202 (-2.9A)
3C0  A1202 (-4.4A)
3C0  A1202 (-3.5A)
3C0  A1202 ( 4.0A)
3C0  A1202 (-3.7A)
3C0  A1202 (-2.9A)
3C0  A1202 (-3.7A)
3C0  A1202 (-3.6A)
 0.66A 5cxvA-4u16A:
39.2		 5cxvA-4u16A:
67.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A 147
TYR A 148
TRP A 199
ALA A 238
CYH A 532
 3C0  A1202 (-3.4A)
3C0  A1202 (-3.7A)
3C0  A1202 (-4.4A)
3C0  A1202 (-3.5A)
3C0  A1202 (-3.6A)
 1.28A 5cxvA-4u16A:
39.2		 5cxvA-4u16A:
67.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASP A  46
GLN A 126
ALA A 131
ALA A 129
ASN A  94
 None
 1.37A 5cxvA-4w6zA:
undetectable		 5cxvA-4w6zA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE

(Mycolicibacterium
smegmatis) 		PF01243
(Putative_PNPOx) 		5 ASP A  94
TRP A 137
ALA A   9
ALA A   6
TRP A  90
 None
 1.45A 5cxvA-4zkyA:
undetectable		 5cxvA-4zkyA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5arm CSP3

(Methylosinus
trichosporium) 		no annotation 5 GLN A  33
ALA A  39
ALA A  37
ASN A  58
CYH A 118
 None
 1.49A 5cxvA-5armA:
undetectable		 5cxvA-5armA:
12.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A 112
TYR A 113
ALA A 203
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 1.37A 5cxvA-5dsgA:
42.1		 5cxvA-5dsgA:
61.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 ASP A 112
TYR A 113
SER A 116
TRP A 164
ALA A 200
ALA A 203
TRP A 413
TYR A 416
ASN A 417
TYR A 439
CYH A 442
 0HK  A1201 (-4.0A)
0HK  A1201 ( 3.2A)
0HK  A1201 (-3.3A)
OLC  A1208 ( 4.0A)
0HK  A1201 ( 4.2A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
0HK  A1201 (-4.2A)
0HK  A1201 (-2.8A)
0HK  A1201 (-3.6A)
0HK  A1201 (-3.6A)
 0.38A 5cxvA-5dsgA:
42.1		 5cxvA-5dsgA:
61.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzz DESMOPLAKIN

(Homo sapiens) 		PF00681
(Plectin) 		5 TYR A2183
SER A2131
GLN A2128
ALA A2053
ALA A2054
 None
 1.41A 5cxvA-5dzzA:
undetectable		 5cxvA-5dzzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		no annotation 5 TYR A 410
GLN A 413
ALA A 137
ALA A 134
TYR A 497
 None
 1.22A 5cxvA-5yh5A:
undetectable		 5cxvA-5yh5A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bp2 ENVELOPE
GLYCOPROTEIN

(Marburg
marburgvirus) 		no annotation 5 ASP A  61
SER A  55
GLN A  57
ALA A 142
TYR A  93
 None
None
NAG  B 704 (-3.9A)
NAG  B 704 ( 4.2A)
None
 1.33A 5cxvA-6bp2A:
undetectable		 5cxvA-6bp2A:
10.78