SIMILAR PATTERNS OF AMINO ACIDS FOR 5CSY_B_ACRB601_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1edy | ALPHA1-MACROGLOBULIN (Rattusnorvegicus) |
PF07677(A2M_recep) | 4 | TYR A 128PHE A 17HIS A 29PRO A 131 | None | 1.30A | 5csyB-1edyA:undetectable | 5csyB-1edyA:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h0p | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE5 (Caenorhabditiselegans) |
PF00160(Pro_isomerase) | 4 | PHE A 49HIS A 116LEU A 122PRO A 24 | None | 1.41A | 5csyB-1h0pA:undetectable | 5csyB-1h0pA:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ioo | SF11-RNASE (Nicotiana alata) |
PF00445(Ribonuclease_T2) | 4 | PHE A 194HIS A 124LEU A 117PRO A 128 | None | 1.49A | 5csyB-1iooA:undetectable | 5csyB-1iooA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itu | RENAL DIPEPTIDASE (Homo sapiens) |
PF01244(Peptidase_M19) | 4 | TYR A 305PHE A 113LEU A 330PRO A 15 | None | 1.46A | 5csyB-1ituA:3.6 | 5csyB-1ituA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j5s | URONATE ISOMERASE (Thermotogamaritima) |
PF02614(UxaC) | 4 | PHE A 449HIS A 439LEU A 391PRO A 29 | None | 1.44A | 5csyB-1j5sA:4.6 | 5csyB-1j5sA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k26 | NUDIX HOMOLOG (Pyrobaculumaerophilum) |
PF00293(NUDIX) | 4 | TYR A 25PHE A 46LEU A 105PRO A 28 | None | 1.44A | 5csyB-1k26A:undetectable | 5csyB-1k26A:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5a | AMIDE SYNTHASE (Vibrio cholerae) |
PF00668(Condensation) | 4 | PHE A 158HIS A 108LEU A 141PRO A 272 | None | 1.27A | 5csyB-1l5aA:undetectable | 5csyB-1l5aA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lw7 | TRANSCRIPTIONALREGULATOR NADR (Haemophilusinfluenzae) |
PF01467(CTP_transf_like)PF13521(AAA_28) | 4 | TYR A 181PHE A 165LEU A 137PRO A 167 | None | 1.43A | 5csyB-1lw7A:undetectable | 5csyB-1lw7A:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mwo | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 4 | TYR A 306PHE A 279HIS A 333PRO A 278 | None | 1.14A | 5csyB-1mwoA:5.4 | 5csyB-1mwoA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1na6 | RESTRICTIONENDONUCLEASE ECORII (Escherichiacoli) |
PF09019(EcoRII-C)PF09217(EcoRII-N) | 4 | TYR A 202PHE A 193LEU A 231PRO A 194 | None | 1.38A | 5csyB-1na6A:2.6 | 5csyB-1na6A:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nx8 | CARBAPENEM SYNTHASE (Pectobacteriumcarotovorum) |
PF02668(TauD) | 4 | TYR A 230PHE A 192HIS A 135LEU A 150 | None | 1.29A | 5csyB-1nx8A:undetectable | 5csyB-1nx8A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p2z | HEXON PROTEIN (HumanmastadenovirusC) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 4 | PHE A 960HIS A 914LEU A 916PRO A 959 | None | 1.23A | 5csyB-1p2zA:undetectable | 5csyB-1p2zA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qu2 | ISOLEUCYL-TRNASYNTHETASE (Staphylococcusaureus) |
PF00133(tRNA-synt_1)PF06827(zf-FPG_IleRS)PF08264(Anticodon_1) | 4 | PHE A 148HIS A 67LEU A 142PRO A 92 | NoneMRC A1993 (-4.1A)NoneNone | 1.49A | 5csyB-1qu2A:undetectable | 5csyB-1qu2A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1txl | METAL-BINDINGPROTEIN YODA (Escherichiacoli) |
PF09223(ZinT) | 4 | TYR A 95PHE A 89HIS A 97LEU A 73 | None | 1.47A | 5csyB-1txlA:undetectable | 5csyB-1txlA:17.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tz7 | 4-ALPHA-GLUCANOTRANSFERASE (Aquifexaeolicus) |
PF02446(Glyco_hydro_77) | 4 | TYR A 58HIS A 287LEU A 335PRO A 452 | None | 0.50A | 5csyB-1tz7A:49.4 | 5csyB-1tz7A:38.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ua4 | ADP-DEPENDENTGLUCOKINASE (Pyrococcusfuriosus) |
PF04587(ADP_PFK_GK) | 4 | PHE A 144HIS A 132LEU A 27PRO A 164 | None | 1.37A | 5csyB-1ua4A:2.4 | 5csyB-1ua4A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ufa | TT1467 PROTEIN (Thermusthermophilus) |
PF03065(Glyco_hydro_57)PF09210(DUF1957) | 4 | TYR A 421PHE A 486HIS A 481LEU A 453 | None | 1.32A | 5csyB-1ufaA:3.2 | 5csyB-1ufaA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wl7 | ARABINANASE-TS (Geobacillusthermodenitrificans) |
PF04616(Glyco_hydro_43) | 4 | TYR A 74PHE A 64LEU A 113PRO A 68 | None | 0.98A | 5csyB-1wl7A:undetectable | 5csyB-1wl7A:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xea | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Vibrio cholerae) |
PF01408(GFO_IDH_MocA) | 4 | PHE A 168HIS A 296LEU A 298PRO A 171 | None | 1.32A | 5csyB-1xeaA:undetectable | 5csyB-1xeaA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2au1 | IGG-DEGRADINGPROTEASE (Streptococcuspyogenes) |
PF09028(Mac-1) | 4 | PHE A 326HIS A 253LEU A 323PRO A 173 | None | 1.42A | 5csyB-2au1A:undetectable | 5csyB-2au1A:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gdu | SUCROSEPHOSPHORYLASE (Bifidobacteriumadolescentis) |
PF00128(Alpha-amylase)PF09244(DUF1964) | 4 | TYR A 196PHE A 140LEU A 113PRO A 139 | None | 1.49A | 5csyB-2gduA:16.4 | 5csyB-2gduA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j7n | RNA-DEPENDENT RNAPOLYMERASE (Neurosporacrassa) |
PF05183(RdRP) | 4 | TYR A 890PHE A 841LEU A 898PRO A 885 | None | 1.39A | 5csyB-2j7nA:undetectable | 5csyB-2j7nA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obe | HEXON (HumanmastadenovirusE) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 4 | PHE A 925HIS A 879LEU A 881PRO A 924 | None | 1.29A | 5csyB-2obeA:undetectable | 5csyB-2obeA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og2 | PUTATIVE SIGNALRECOGNITION PARTICLERECEPTOR (Arabidopsisthaliana) |
PF00448(SRP54)PF02881(SRP54_N) | 4 | PHE A 304HIS A 148LEU A 150PRO A 316 | None | 1.28A | 5csyB-2og2A:2.2 | 5csyB-2og2A:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vyc | BIODEGRADATIVEARGININEDECARBOXYLASE (Escherichiacoli) |
PF01276(OKR_DC_1)PF03709(OKR_DC_1_N)PF03711(OKR_DC_1_C) | 4 | PHE A 521HIS A 363LEU A 531PRO A 284 | None | 1.44A | 5csyB-2vycA:undetectable | 5csyB-2vycA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsk | GLYCOGEN DEBRANCHINGENZYME (Escherichiacoli) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 4 | PHE A 550HIS A 556LEU A 504PRO A 632 | None | 1.41A | 5csyB-2wskA:18.5 | 5csyB-2wskA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwu | DNA-3-METHYLADENINEGLYCOSYLASE 2 (Escherichiacoli) |
PF00730(HhH-GPD)PF06029(AlkA_N) | 4 | PHE A 18HIS A 270LEU A 268PRO A 108 | None | 1.49A | 5csyB-3cwuA:undetectable | 5csyB-3cwuA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3a | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF01301(Glyco_hydro_35) | 4 | PHE A 512HIS A 385LEU A 383PRO A 507 | None | 1.37A | 5csyB-3d3aA:9.7 | 5csyB-3d3aA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3edp | LIN2111 PROTEIN (Listeriainnocua) |
PF00392(GntR)PF07702(UTRA) | 4 | TYR A 69PHE A 101LEU A 150PRO A 72 | None | 1.45A | 5csyB-3edpA:undetectable | 5csyB-3edpA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fn1 | NEDD8-CONJUGATINGENZYME UBE2F (Homo sapiens) |
PF00179(UQ_con) | 4 | TYR B 75HIS B 164LEU B 166PRO B 107 | None | 1.30A | 5csyB-3fn1B:undetectable | 5csyB-3fn1B:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbj | FLAVONOID3-O-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 4 | PHE A 239HIS A 155LEU A 153PRO A 214 | None | 1.45A | 5csyB-3hbjA:undetectable | 5csyB-3hbjA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k65 | PROTHROMBIN (Homo sapiens) |
PF00051(Kringle) | 4 | TYR A 242PHE A 208LEU A 202PRO A 222 | NoneNoneBU1 A 599 ( 4.7A)None | 1.43A | 5csyB-3k65A:undetectable | 5csyB-3k65A:12.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nby | SNURPORTIN-1 (Homo sapiens) |
PF11538(Snurportin1) | 4 | TYR B 265HIS B 264LEU B 55PRO B 194 | None | 1.43A | 5csyB-3nbyB:undetectable | 5csyB-3nbyB:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3q | ALKALINE PHOSPHATASE (Sphingomonassp. BSAR-1) |
PF01663(Phosphodiest) | 4 | PHE A 51HIS A 93LEU A 296PRO A 502 | None | 1.29A | 5csyB-3q3qA:undetectable | 5csyB-3q3qA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmv | GLYCOGENIN-1 (Homo sapiens) |
PF01501(Glyco_transf_8) | 4 | TYR A 224PHE A 213LEU A 248PRO A 219 | None | 1.47A | 5csyB-3rmvA:undetectable | 5csyB-3rmvA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rv6 | ISOCHORISMATESYNTHASE/ISOCHORISMATE-PYRUVATE LYASEMBTI (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind) | 4 | PHE A 112HIS A 117LEU A 121PRO A 358 | None | 1.09A | 5csyB-3rv6A:undetectable | 5csyB-3rv6A:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3to3 | PETROBACTINBIOSYNTHESIS PROTEINASBB (Bacillusanthracis) |
PF04183(IucA_IucC)PF06276(FhuF) | 4 | TYR A 560PHE A 75LEU A 509PRO A 588 | None | 1.35A | 5csyB-3to3A:undetectable | 5csyB-3to3A:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0a | NTNH (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 4 | TYR B 372PHE B 78LEU B 86PRO B 205 | None | 1.41A | 5csyB-3v0aB:undetectable | 5csyB-3v0aB:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vuo | NTNHA (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 4 | TYR A 372PHE A 78LEU A 86PRO A 205 | None | 1.47A | 5csyB-3vuoA:undetectable | 5csyB-3vuoA:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zif | HEXON PROTEIN (BovinemastadenovirusB) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 4 | PHE A 904HIS A 858LEU A 860PRO A 903 | None | 1.39A | 5csyB-3zifA:undetectable | 5csyB-3zifA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zzu | ELONGATION FACTOR G (Staphylococcusaureus) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF14492(EFG_II) | 4 | TYR A 186PHE A 144LEU A 257PRO A 165 | None | 1.37A | 5csyB-3zzuA:undetectable | 5csyB-3zzuA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8s | ADP-DEPENDENTGLUCOKINASE (Thermococcuslitoralis) |
PF04587(ADP_PFK_GK) | 4 | PHE A 152HIS A 140LEU A 35PRO A 172 | None | 1.37A | 5csyB-4b8sA:undetectable | 5csyB-4b8sA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ds2 | UBIQUITIN-CONJUGATING ENZYME E2,PUTATIVE (Trypanosomacruzi) |
PF00179(UQ_con) | 4 | PHE A 73HIS A 115LEU A 16PRO A 82 | None | 1.02A | 5csyB-4ds2A:undetectable | 5csyB-4ds2A:13.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ejr | MAJOR CAPSID PROTEINVP60 (Rabbithemorrhagicdisease virus) |
PF00915(Calici_coat) | 4 | TYR A 73PHE A 221LEU A 106PRO A 217 | None | 1.40A | 5csyB-4ejrA:undetectable | 5csyB-4ejrA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gc5 | DIMETHYLADENOSINETRANSFERASE 1,MITOCHONDRIAL (Mus musculus) |
PF00398(RrnaAD) | 4 | PHE A 165HIS A 137LEU A 230PRO A 164 | None | 1.22A | 5csyB-4gc5A:undetectable | 5csyB-4gc5A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i9c | RESPONSE REGULATORASPARTATEPHOSPHATASE F (Bacillussubtilis) |
PF12895(ANAPC3)PF13424(TPR_12) | 4 | TYR A 18PHE A 24HIS A 60LEU A 62 | None | 1.24A | 5csyB-4i9cA:undetectable | 5csyB-4i9cA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ka8 | OLIGOPEPTIDASE A (Arabidopsisthaliana) |
PF01432(Peptidase_M3) | 4 | TYR A 504PHE A 573HIS A 579LEU A 581 | GOL A 804 (-4.7A)NoneNoneNone | 1.43A | 5csyB-4ka8A:undetectable | 5csyB-4ka8A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kqb | PROTEIN H03A11.1 (Caenorhabditiselegans) |
PF06702(Fam20C) | 4 | TYR A 147PHE A 373HIS A 385LEU A 386 | NoneNoneNoneADP A 608 ( 4.6A) | 1.39A | 5csyB-4kqbA:undetectable | 5csyB-4kqbA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kqn | D-HYDANTOINASE (Bacillus sp.AR9) |
PF01979(Amidohydro_1) | 4 | TYR A 210HIS A 208LEU A 291PRO A 214 | TYR A 210 ( 1.3A)HIS A 208 ( 1.0A)LEU A 291 ( 0.6A)PRO A 214 ( 1.1A) | 1.18A | 5csyB-4kqnA:3.6 | 5csyB-4kqnA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nrh | CHAPERONE SYCD (Chlamydiapneumoniae) |
PF07720(TPR_3) | 4 | TYR B 28PHE B 86LEU B 40PRO B 85 | None | 1.40A | 5csyB-4nrhB:undetectable | 5csyB-4nrhB:15.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p2b | GLUTAMINEAMINOACYL-TRNASYNTHETASE (Toxoplasmagondii) |
PF00749(tRNA-synt_1c)PF03950(tRNA-synt_1c_C) | 4 | TYR A 91PHE A 45LEU A 306PRO A 47 | None | 1.14A | 5csyB-4p2bA:2.6 | 5csyB-4p2bA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s1j | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Leishmaniadonovani) |
PF00160(Pro_isomerase) | 4 | PHE A 48HIS A 115LEU A 120PRO A 23 | None | 1.34A | 5csyB-4s1jA:undetectable | 5csyB-4s1jA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ymk | ACYL-COA DESATURASE1 (Mus musculus) |
PF00487(FA_desaturase) | 4 | TYR A 269PHE A 293HIS A 352LEU A 358 | None | 1.15A | 5csyB-4ymkA:undetectable | 5csyB-4ymkA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypt | REPLICASEPOLYPROTEIN 1AB (Murinecoronavirus) |
PF08715(Viral_protease) | 4 | TYR A1874PHE A1709HIS A1876LEU A1725 | None | 1.13A | 5csyB-4yptA:undetectable | 5csyB-4yptA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zg7 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 2 (Homo sapiens) |
PF01033(Somatomedin_B)PF01223(Endonuclease_NS)PF01663(Phosphodiest) | 4 | PHE A 161HIS A 349LEU A 346PRO A 165 | None | 0.76A | 5csyB-4zg7A:undetectable | 5csyB-4zg7A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5co8 | NUCLEASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF00752(XPG_N)PF00867(XPG_I) | 4 | PHE A 295HIS A 25LEU A 35PRO A 296 | None | 1.25A | 5csyB-5co8A:undetectable | 5csyB-5co8A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cs0 | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF08326(ACC_central) | 4 | PHE A 876HIS A 912LEU A 907PRO A 877 | None | 1.43A | 5csyB-5cs0A:undetectable | 5csyB-5cs0A:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5csa | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF00364(Biotin_lipoyl)PF08326(ACC_central) | 4 | PHE A 876HIS A 912LEU A 907PRO A 877 | None | 1.47A | 5csyB-5csaA:undetectable | 5csyB-5csaA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5csl | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF01039(Carboxyl_trans)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2)PF08326(ACC_central) | 4 | PHE A 876HIS A 912LEU A 907PRO A 877 | None | 1.40A | 5csyB-5cslA:undetectable | 5csyB-5cslA:13.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5csu | 4-ALPHA-GLUCANOTRANSFERASE DPE1,CHLOROPLASTIC/AMYLOPLASTIC (Arabidopsisthaliana) |
PF02446(Glyco_hydro_77) | 5 | TYR A 136PHE A 331HIS A 374LEU A 422PRO A 539 | HMC A 606 ( 4.0A)GLC A 608 ( 4.7A)AGL A 607 ( 3.8A)GLC A 608 ( 3.8A)GLC A 605 ( 3.6A) | 0.13A | 5csyB-5csuA:60.3 | 5csyB-5csuA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dkv | ABC TRANSPORTERSUBSTRATE BINDINGPROTEIN (RIBOSE) (Agrobacteriumvitis) |
PF13407(Peripla_BP_4) | 4 | TYR A 142PHE A 138LEU A 103PRO A 139 | None | 1.40A | 5csyB-5dkvA:undetectable | 5csyB-5dkvA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fv4 | CARBOXYLIC ESTERHYDROLASE (Sus scrofa) |
PF00135(COesterase) | 4 | PHE A 454HIS A 449LEU A 83PRO A 434 | None | 1.16A | 5csyB-5fv4A:undetectable | 5csyB-5fv4A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fx8 | LINOLEATE11-LIPOXYGENASE (Gaeumannomycesavenae) |
PF00305(Lipoxygenase) | 4 | TYR A 289PHE A 397HIS A 478PRO A 173 | NoneNone MN A1000 (-3.4A)None | 1.22A | 5csyB-5fx8A:undetectable | 5csyB-5fx8A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5t | ARGONAUTE (Methanocaldococcusjannaschii) |
PF02171(Piwi) | 4 | TYR A 677PHE A 622HIS A 685PRO A 624 | None | 1.41A | 5csyB-5g5tA:undetectable | 5csyB-5g5tA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hvo | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Aspergillusfumigatus) |
PF00982(Glyco_transf_20) | 4 | PHE A 182HIS A 224LEU A 225PRO A 183 | None | 1.40A | 5csyB-5hvoA:undetectable | 5csyB-5hvoA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6e | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF08326(ACC_central) | 4 | PHE A 876HIS A 912LEU A 907PRO A 877 | None | 1.46A | 5csyB-5i6eA:undetectable | 5csyB-5i6eA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikz | OXALATE BIOSYNTHETICCOMPONENT 1 (Burkholderiathailandensis) |
PF05853(BKACE) | 4 | PHE A 456HIS A 421LEU A 412PRO A 455 | None | 1.36A | 5csyB-5ikzA:4.7 | 5csyB-5ikzA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j62 | PUTATIVE REDUCTASE (Clostridioidesdifficile) |
PF00881(Nitroreductase) | 4 | TYR A 185PHE A 189LEU A 114PRO A 188 | NoneFMN A 301 ( 4.8A)NoneNone | 1.39A | 5csyB-5j62A:undetectable | 5csyB-5j62A:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldn | HEXON PROTEIN,HEXONCAPSID (HumanmastadenovirusC) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 4 | PHE A 944HIS A 898LEU A 900PRO A 943 | None | 1.34A | 5csyB-5ldnA:undetectable | 5csyB-5ldnA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0j | ADP-DEPENDENTGLUCOKINASE (Pyrococcushorikoshii) |
no annotation | 4 | PHE A 147HIS A 135LEU A 30PRO A 167 | None | 1.34A | 5csyB-5o0jA:undetectable | 5csyB-5o0jA:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5olj | DIPEPTIDYL PEPTIDASEIV (Porphyromonasgingivalis) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 4 | PHE A 498HIS A 503LEU A 579PRO A 495 | None | 1.45A | 5csyB-5oljA:undetectable | 5csyB-5oljA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vh6 | ELONGATION FACTOR G (Bacillussubtilis) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2) | 4 | TYR A 186PHE A 144LEU A 257PRO A 165 | CL A 501 (-4.7A)NoneNoneNone | 1.28A | 5csyB-5vh6A:undetectable | 5csyB-5vh6A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vkt | CINNAMYL ALCOHOLDEHYDROGENASES(SBCAD4) (Sorghum bicolor) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | TYR A 63PHE A 137LEU A 51PRO A 67 | None | 1.49A | 5csyB-5vktA:undetectable | 5csyB-5vktA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | 40S RIBOSOMALPROTEIN S5-B,PUTATIVE (Trichomonasvaginalis) |
PF00177(Ribosomal_S7) | 4 | PHE F 86HIS F 35LEU F 57PRO F 97 | None | 1.42A | 5csyB-5xyiF:undetectable | 5csyB-5xyiF:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y00 | GREEN FLUORESCENTPROTEIN (Olindias) |
no annotation | 4 | TYR A 238HIS A 157LEU A 164PRO A 197 | GOL A 302 ( 4.4A)NoneNoneNone | 1.39A | 5csyB-5y00A:undetectable | 5csyB-5y00A:9.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y31 | DISINTEGRIN ANDMETALLOPROTEINASEDOMAIN-CONTAININGPROTEIN 22 (Homo sapiens) |
no annotation | 4 | TYR A 344PHE A 335HIS A 328LEU A 329 | None | 1.27A | 5csyB-5y31A:undetectable | 5csyB-5y31A:8.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk7 | ELONGATION FACTOR G (Enterococcusfaecalis) |
no annotation | 4 | TYR A 186PHE A 144LEU A 257PRO A 165 | None | 1.38A | 5csyB-6bk7A:undetectable | 5csyB-6bk7A:8.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byw | GOXA (Pseudoalteromonasluteoviolacea) |
no annotation | 4 | TYR B 154PHE B 619LEU B 616PRO B 11 | None | 0.80A | 5csyB-6bywB:undetectable | 5csyB-6bywB:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eon | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
no annotation | 4 | PHE A 512HIS A 385LEU A 383PRO A 507 | None | 1.35A | 5csyB-6eonA:10.3 | 5csyB-6eonA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f5d | ATP SYNTHASE SUBUNITBETA (Trypanosomabrucei) |
no annotation | 4 | TYR D 247PHE D 101LEU D 97PRO D 91 | None | 1.47A | 5csyB-6f5dD:undetectable | 5csyB-6f5dD:9.59 |