SIMILAR PATTERNS OF AMINO ACIDS FOR 5CSY_B_ACRB601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edy ALPHA
1-MACROGLOBULIN


(Rattus
norvegicus)
PF07677
(A2M_recep)
4 TYR A 128
PHE A  17
HIS A  29
PRO A 131
None
1.30A 5csyB-1edyA:
undetectable
5csyB-1edyA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5


(Caenorhabditis
elegans)
PF00160
(Pro_isomerase)
4 PHE A  49
HIS A 116
LEU A 122
PRO A  24
None
1.41A 5csyB-1h0pA:
undetectable
5csyB-1h0pA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioo SF11-RNASE

(Nicotiana alata)
PF00445
(Ribonuclease_T2)
4 PHE A 194
HIS A 124
LEU A 117
PRO A 128
None
1.49A 5csyB-1iooA:
undetectable
5csyB-1iooA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens)
PF01244
(Peptidase_M19)
4 TYR A 305
PHE A 113
LEU A 330
PRO A  15
None
1.46A 5csyB-1ituA:
3.6
5csyB-1ituA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima)
PF02614
(UxaC)
4 PHE A 449
HIS A 439
LEU A 391
PRO A  29
None
1.44A 5csyB-1j5sA:
4.6
5csyB-1j5sA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k26 NUDIX HOMOLOG

(Pyrobaculum
aerophilum)
PF00293
(NUDIX)
4 TYR A  25
PHE A  46
LEU A 105
PRO A  28
None
1.44A 5csyB-1k26A:
undetectable
5csyB-1k26A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae)
PF00668
(Condensation)
4 PHE A 158
HIS A 108
LEU A 141
PRO A 272
None
1.27A 5csyB-1l5aA:
undetectable
5csyB-1l5aA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw7 TRANSCRIPTIONAL
REGULATOR NADR


(Haemophilus
influenzae)
PF01467
(CTP_transf_like)
PF13521
(AAA_28)
4 TYR A 181
PHE A 165
LEU A 137
PRO A 167
None
1.43A 5csyB-1lw7A:
undetectable
5csyB-1lw7A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei)
PF00128
(Alpha-amylase)
PF09154
(DUF1939)
4 TYR A 306
PHE A 279
HIS A 333
PRO A 278
None
1.14A 5csyB-1mwoA:
5.4
5csyB-1mwoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1na6 RESTRICTION
ENDONUCLEASE ECORII


(Escherichia
coli)
PF09019
(EcoRII-C)
PF09217
(EcoRII-N)
4 TYR A 202
PHE A 193
LEU A 231
PRO A 194
None
1.38A 5csyB-1na6A:
2.6
5csyB-1na6A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nx8 CARBAPENEM SYNTHASE

(Pectobacterium
carotovorum)
PF02668
(TauD)
4 TYR A 230
PHE A 192
HIS A 135
LEU A 150
None
1.29A 5csyB-1nx8A:
undetectable
5csyB-1nx8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
4 PHE A 960
HIS A 914
LEU A 916
PRO A 959
None
1.23A 5csyB-1p2zA:
undetectable
5csyB-1p2zA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE


(Staphylococcus
aureus)
PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1)
4 PHE A 148
HIS A  67
LEU A 142
PRO A  92
None
MRC  A1993 (-4.1A)
None
None
1.49A 5csyB-1qu2A:
undetectable
5csyB-1qu2A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txl METAL-BINDING
PROTEIN YODA


(Escherichia
coli)
PF09223
(ZinT)
4 TYR A  95
PHE A  89
HIS A  97
LEU A  73
None
1.47A 5csyB-1txlA:
undetectable
5csyB-1txlA:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE


(Aquifex
aeolicus)
PF02446
(Glyco_hydro_77)
4 TYR A  58
HIS A 287
LEU A 335
PRO A 452
None
0.50A 5csyB-1tz7A:
49.4
5csyB-1tz7A:
38.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE


(Pyrococcus
furiosus)
PF04587
(ADP_PFK_GK)
4 PHE A 144
HIS A 132
LEU A  27
PRO A 164
None
1.37A 5csyB-1ua4A:
2.4
5csyB-1ua4A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus)
PF03065
(Glyco_hydro_57)
PF09210
(DUF1957)
4 TYR A 421
PHE A 486
HIS A 481
LEU A 453
None
1.32A 5csyB-1ufaA:
3.2
5csyB-1ufaA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl7 ARABINANASE-TS

(Geobacillus
thermodenitrificans)
PF04616
(Glyco_hydro_43)
4 TYR A  74
PHE A  64
LEU A 113
PRO A  68
None
0.98A 5csyB-1wl7A:
undetectable
5csyB-1wl7A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY


(Vibrio cholerae)
PF01408
(GFO_IDH_MocA)
4 PHE A 168
HIS A 296
LEU A 298
PRO A 171
None
1.32A 5csyB-1xeaA:
undetectable
5csyB-1xeaA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE


(Streptococcus
pyogenes)
PF09028
(Mac-1)
4 PHE A 326
HIS A 253
LEU A 323
PRO A 173
None
1.42A 5csyB-2au1A:
undetectable
5csyB-2au1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE


(Bifidobacterium
adolescentis)
PF00128
(Alpha-amylase)
PF09244
(DUF1964)
4 TYR A 196
PHE A 140
LEU A 113
PRO A 139
None
1.49A 5csyB-2gduA:
16.4
5csyB-2gduA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE


(Neurospora
crassa)
PF05183
(RdRP)
4 TYR A 890
PHE A 841
LEU A 898
PRO A 885
None
1.39A 5csyB-2j7nA:
undetectable
5csyB-2j7nA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
4 PHE A 925
HIS A 879
LEU A 881
PRO A 924
None
1.29A 5csyB-2obeA:
undetectable
5csyB-2obeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR


(Arabidopsis
thaliana)
PF00448
(SRP54)
PF02881
(SRP54_N)
4 PHE A 304
HIS A 148
LEU A 150
PRO A 316
None
1.28A 5csyB-2og2A:
2.2
5csyB-2og2A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE


(Escherichia
coli)
PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C)
4 PHE A 521
HIS A 363
LEU A 531
PRO A 284
None
1.44A 5csyB-2vycA:
undetectable
5csyB-2vycA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME


(Escherichia
coli)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 PHE A 550
HIS A 556
LEU A 504
PRO A 632
None
1.41A 5csyB-2wskA:
18.5
5csyB-2wskA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2


(Escherichia
coli)
PF00730
(HhH-GPD)
PF06029
(AlkA_N)
4 PHE A  18
HIS A 270
LEU A 268
PRO A 108
None
1.49A 5csyB-3cwuA:
undetectable
5csyB-3cwuA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF01301
(Glyco_hydro_35)
4 PHE A 512
HIS A 385
LEU A 383
PRO A 507
None
1.37A 5csyB-3d3aA:
9.7
5csyB-3d3aA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edp LIN2111 PROTEIN

(Listeria
innocua)
PF00392
(GntR)
PF07702
(UTRA)
4 TYR A  69
PHE A 101
LEU A 150
PRO A  72
None
1.45A 5csyB-3edpA:
undetectable
5csyB-3edpA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn1 NEDD8-CONJUGATING
ENZYME UBE2F


(Homo sapiens)
PF00179
(UQ_con)
4 TYR B  75
HIS B 164
LEU B 166
PRO B 107
None
1.30A 5csyB-3fn1B:
undetectable
5csyB-3fn1B:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE


(Medicago
truncatula)
PF00201
(UDPGT)
4 PHE A 239
HIS A 155
LEU A 153
PRO A 214
None
1.45A 5csyB-3hbjA:
undetectable
5csyB-3hbjA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k65 PROTHROMBIN

(Homo sapiens)
PF00051
(Kringle)
4 TYR A 242
PHE A 208
LEU A 202
PRO A 222
None
None
BU1  A 599 ( 4.7A)
None
1.43A 5csyB-3k65A:
undetectable
5csyB-3k65A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nby SNURPORTIN-1

(Homo sapiens)
PF11538
(Snurportin1)
4 TYR B 265
HIS B 264
LEU B  55
PRO B 194
None
1.43A 5csyB-3nbyB:
undetectable
5csyB-3nbyB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3q ALKALINE PHOSPHATASE

(Sphingomonas
sp. BSAR-1)
PF01663
(Phosphodiest)
4 PHE A  51
HIS A  93
LEU A 296
PRO A 502
None
1.29A 5csyB-3q3qA:
undetectable
5csyB-3q3qA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmv GLYCOGENIN-1

(Homo sapiens)
PF01501
(Glyco_transf_8)
4 TYR A 224
PHE A 213
LEU A 248
PRO A 219
None
1.47A 5csyB-3rmvA:
undetectable
5csyB-3rmvA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI


(Mycobacterium
tuberculosis)
PF00425
(Chorismate_bind)
4 PHE A 112
HIS A 117
LEU A 121
PRO A 358
None
1.09A 5csyB-3rv6A:
undetectable
5csyB-3rv6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB


(Bacillus
anthracis)
PF04183
(IucA_IucC)
PF06276
(FhuF)
4 TYR A 560
PHE A  75
LEU A 509
PRO A 588
None
1.35A 5csyB-3to3A:
undetectable
5csyB-3to3A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C)
4 TYR B 372
PHE B  78
LEU B  86
PRO B 205
None
1.41A 5csyB-3v0aB:
undetectable
5csyB-3v0aB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C)
4 TYR A 372
PHE A  78
LEU A  86
PRO A 205
None
1.47A 5csyB-3vuoA:
undetectable
5csyB-3vuoA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
4 PHE A 904
HIS A 858
LEU A 860
PRO A 903
None
1.39A 5csyB-3zifA:
undetectable
5csyB-3zifA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II)
4 TYR A 186
PHE A 144
LEU A 257
PRO A 165
None
1.37A 5csyB-3zzuA:
undetectable
5csyB-3zzuA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE


(Thermococcus
litoralis)
PF04587
(ADP_PFK_GK)
4 PHE A 152
HIS A 140
LEU A  35
PRO A 172
None
1.37A 5csyB-4b8sA:
undetectable
5csyB-4b8sA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ds2 UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE


(Trypanosoma
cruzi)
PF00179
(UQ_con)
4 PHE A  73
HIS A 115
LEU A  16
PRO A  82
None
1.02A 5csyB-4ds2A:
undetectable
5csyB-4ds2A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejr MAJOR CAPSID PROTEIN
VP60


(Rabbit
hemorrhagic
disease virus)
PF00915
(Calici_coat)
4 TYR A  73
PHE A 221
LEU A 106
PRO A 217
None
1.40A 5csyB-4ejrA:
undetectable
5csyB-4ejrA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL


(Mus musculus)
PF00398
(RrnaAD)
4 PHE A 165
HIS A 137
LEU A 230
PRO A 164
None
1.22A 5csyB-4gc5A:
undetectable
5csyB-4gc5A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F


(Bacillus
subtilis)
PF12895
(ANAPC3)
PF13424
(TPR_12)
4 TYR A  18
PHE A  24
HIS A  60
LEU A  62
None
1.24A 5csyB-4i9cA:
undetectable
5csyB-4i9cA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana)
PF01432
(Peptidase_M3)
4 TYR A 504
PHE A 573
HIS A 579
LEU A 581
GOL  A 804 (-4.7A)
None
None
None
1.43A 5csyB-4ka8A:
undetectable
5csyB-4ka8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqb PROTEIN H03A11.1

(Caenorhabditis
elegans)
PF06702
(Fam20C)
4 TYR A 147
PHE A 373
HIS A 385
LEU A 386
None
None
None
ADP  A 608 ( 4.6A)
1.39A 5csyB-4kqbA:
undetectable
5csyB-4kqbA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9)
PF01979
(Amidohydro_1)
4 TYR A 210
HIS A 208
LEU A 291
PRO A 214
TYR  A 210 ( 1.3A)
HIS  A 208 ( 1.0A)
LEU  A 291 ( 0.6A)
PRO  A 214 ( 1.1A)
1.18A 5csyB-4kqnA:
3.6
5csyB-4kqnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh CHAPERONE SYCD

(Chlamydia
pneumoniae)
PF07720
(TPR_3)
4 TYR B  28
PHE B  86
LEU B  40
PRO B  85
None
1.40A 5csyB-4nrhB:
undetectable
5csyB-4nrhB:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2b GLUTAMINE
AMINOACYL-TRNA
SYNTHETASE


(Toxoplasma
gondii)
PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
4 TYR A  91
PHE A  45
LEU A 306
PRO A  47
None
1.14A 5csyB-4p2bA:
2.6
5csyB-4p2bA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1j PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Leishmania
donovani)
PF00160
(Pro_isomerase)
4 PHE A  48
HIS A 115
LEU A 120
PRO A  23
None
1.34A 5csyB-4s1jA:
undetectable
5csyB-4s1jA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1


(Mus musculus)
PF00487
(FA_desaturase)
4 TYR A 269
PHE A 293
HIS A 352
LEU A 358
None
1.15A 5csyB-4ymkA:
undetectable
5csyB-4ymkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypt REPLICASE
POLYPROTEIN 1AB


(Murine
coronavirus)
PF08715
(Viral_protease)
4 TYR A1874
PHE A1709
HIS A1876
LEU A1725
None
1.13A 5csyB-4yptA:
undetectable
5csyB-4yptA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2


(Homo sapiens)
PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest)
4 PHE A 161
HIS A 349
LEU A 346
PRO A 165
None
0.76A 5csyB-4zg7A:
undetectable
5csyB-4zg7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co8 NUCLEASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF00752
(XPG_N)
PF00867
(XPG_I)
4 PHE A 295
HIS A  25
LEU A  35
PRO A 296
None
1.25A 5csyB-5co8A:
undetectable
5csyB-5co8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs0 ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF08326
(ACC_central)
4 PHE A 876
HIS A 912
LEU A 907
PRO A 877
None
1.43A 5csyB-5cs0A:
undetectable
5csyB-5cs0A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00364
(Biotin_lipoyl)
PF08326
(ACC_central)
4 PHE A 876
HIS A 912
LEU A 907
PRO A 877
None
1.47A 5csyB-5csaA:
undetectable
5csyB-5csaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central)
4 PHE A 876
HIS A 912
LEU A 907
PRO A 877
None
1.40A 5csyB-5cslA:
undetectable
5csyB-5cslA:
13.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC


(Arabidopsis
thaliana)
PF02446
(Glyco_hydro_77)
5 TYR A 136
PHE A 331
HIS A 374
LEU A 422
PRO A 539
HMC  A 606 ( 4.0A)
GLC  A 608 ( 4.7A)
AGL  A 607 ( 3.8A)
GLC  A 608 ( 3.8A)
GLC  A 605 ( 3.6A)
0.13A 5csyB-5csuA:
60.3
5csyB-5csuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)


(Agrobacterium
vitis)
PF13407
(Peripla_BP_4)
4 TYR A 142
PHE A 138
LEU A 103
PRO A 139
None
1.40A 5csyB-5dkvA:
undetectable
5csyB-5dkvA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE


(Sus scrofa)
PF00135
(COesterase)
4 PHE A 454
HIS A 449
LEU A  83
PRO A 434
None
1.16A 5csyB-5fv4A:
undetectable
5csyB-5fv4A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE


(Gaeumannomyces
avenae)
PF00305
(Lipoxygenase)
4 TYR A 289
PHE A 397
HIS A 478
PRO A 173
None
None
MN  A1000 (-3.4A)
None
1.22A 5csyB-5fx8A:
undetectable
5csyB-5fx8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5t ARGONAUTE

(Methanocaldococcus
jannaschii)
PF02171
(Piwi)
4 TYR A 677
PHE A 622
HIS A 685
PRO A 624
None
1.41A 5csyB-5g5tA:
undetectable
5csyB-5g5tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Aspergillus
fumigatus)
PF00982
(Glyco_transf_20)
4 PHE A 182
HIS A 224
LEU A 225
PRO A 183
None
1.40A 5csyB-5hvoA:
undetectable
5csyB-5hvoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF08326
(ACC_central)
4 PHE A 876
HIS A 912
LEU A 907
PRO A 877
None
1.46A 5csyB-5i6eA:
undetectable
5csyB-5i6eA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1


(Burkholderia
thailandensis)
PF05853
(BKACE)
4 PHE A 456
HIS A 421
LEU A 412
PRO A 455
None
1.36A 5csyB-5ikzA:
4.7
5csyB-5ikzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j62 PUTATIVE REDUCTASE

(Clostridioides
difficile)
PF00881
(Nitroreductase)
4 TYR A 185
PHE A 189
LEU A 114
PRO A 188
None
FMN  A 301 ( 4.8A)
None
None
1.39A 5csyB-5j62A:
undetectable
5csyB-5j62A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID


(Human
mastadenovirus
C)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
4 PHE A 944
HIS A 898
LEU A 900
PRO A 943
None
1.34A 5csyB-5ldnA:
undetectable
5csyB-5ldnA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE


(Pyrococcus
horikoshii)
no annotation 4 PHE A 147
HIS A 135
LEU A  30
PRO A 167
None
1.34A 5csyB-5o0jA:
undetectable
5csyB-5o0jA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV


(Porphyromonas
gingivalis)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
4 PHE A 498
HIS A 503
LEU A 579
PRO A 495
None
1.45A 5csyB-5oljA:
undetectable
5csyB-5oljA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vh6 ELONGATION FACTOR G

(Bacillus
subtilis)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
4 TYR A 186
PHE A 144
LEU A 257
PRO A 165
CL  A 501 (-4.7A)
None
None
None
1.28A 5csyB-5vh6A:
undetectable
5csyB-5vh6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)


(Sorghum bicolor)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 TYR A  63
PHE A 137
LEU A  51
PRO A  67
None
1.49A 5csyB-5vktA:
undetectable
5csyB-5vktA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S5-B,
PUTATIVE


(Trichomonas
vaginalis)
PF00177
(Ribosomal_S7)
4 PHE F  86
HIS F  35
LEU F  57
PRO F  97
None
1.42A 5csyB-5xyiF:
undetectable
5csyB-5xyiF:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y00 GREEN FLUORESCENT
PROTEIN


(Olindias)
no annotation 4 TYR A 238
HIS A 157
LEU A 164
PRO A 197
GOL  A 302 ( 4.4A)
None
None
None
1.39A 5csyB-5y00A:
undetectable
5csyB-5y00A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22


(Homo sapiens)
no annotation 4 TYR A 344
PHE A 335
HIS A 328
LEU A 329
None
1.27A 5csyB-5y31A:
undetectable
5csyB-5y31A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis)
no annotation 4 TYR A 186
PHE A 144
LEU A 257
PRO A 165
None
1.38A 5csyB-6bk7A:
undetectable
5csyB-6bk7A:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea)
no annotation 4 TYR B 154
PHE B 619
LEU B 616
PRO B  11
None
0.80A 5csyB-6bywB:
undetectable
5csyB-6bywB:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
no annotation 4 PHE A 512
HIS A 385
LEU A 383
PRO A 507
None
1.35A 5csyB-6eonA:
10.3
5csyB-6eonA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA


(Trypanosoma
brucei)
no annotation 4 TYR D 247
PHE D 101
LEU D  97
PRO D  91
None
1.47A 5csyB-6f5dD:
undetectable
5csyB-6f5dD:
9.59