SIMILAR PATTERNS OF AMINO ACIDS FOR 5CSY_B_ACRB601
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1amy | 1,4-ALPHA-D-GLUCANGLUCANOHYDROLASE (Hordeum vulgare) |
PF00128(Alpha-amylase)PF07821(Alpha-amyl_C2) | 5 | ARG A 177ASP A 179GLU A 204HIS A 288ASP A 289 | None | 0.31A | 5csyB-1amyA:4.8 | 5csyB-1amyA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bf2 | ISOAMYLASE (Pseudomonasamyloderamosa) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | ARG A 373ASP A 375GLU A 435HIS A 509ASP A 510 | None | 0.48A | 5csyB-1bf2A:12.7 | 5csyB-1bf2A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bpl | ALPHA-1,4-GLUCAN-4-GLUCANOHYDROLASE (Bacilluslicheniformis) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ARG B 229ASP B 231GLU B 261HIS B 327ASP B 328 | None | 0.56A | 5csyB-1bplB:6.0 | 5csyB-1bplB:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e43 | ALPHA-AMYLASE (Bacillusamyloliquefaciens) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ARG A 229ASP A 231GLU A 261HIS A 327ASP A 328 | None | 0.48A | 5csyB-1e43A:6.0 | 5csyB-1e43A:22.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fp9 | 4-ALPHA-GLUCANOTRANSFERASE (Thermusthermophilus) |
PF02446(Glyco_hydro_77) | 6 | ARG A 291ASP A 293GLY A 343PHE A 366HIS A 394ASP A 395 | None | 1.06A | 5csyB-1fp9A:48.4 | 5csyB-1fp9A:38.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fp9 | 4-ALPHA-GLUCANOTRANSFERASE (Thermusthermophilus) |
PF02446(Glyco_hydro_77) | 5 | GLN A 256TRP A 258ASP A 293GLY A 343PHE A 366 | None | 0.95A | 5csyB-1fp9A:48.4 | 5csyB-1fp9A:38.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fp9 | 4-ALPHA-GLUCANOTRANSFERASE (Thermusthermophilus) |
PF02446(Glyco_hydro_77) | 6 | TRP A 258ASP A 293GLU A 340GLY A 343PHE A 366HIS A 394 | None | 1.13A | 5csyB-1fp9A:48.4 | 5csyB-1fp9A:38.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fp9 | 4-ALPHA-GLUCANOTRANSFERASE (Thermusthermophilus) |
PF02446(Glyco_hydro_77) | 6 | TRP A 258ASP A 293GLY A 343PHE A 366HIS A 394ASP A 395 | None | 1.10A | 5csyB-1fp9A:48.4 | 5csyB-1fp9A:38.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3g | CYCLOMALTODEXTRINASE (Flavobacteriumsp. 92) |
PF00128(Alpha-amylase)PF09087(Cyc-maltodext_N)PF10438(Cyc-maltodext_C) | 5 | ARG A 309ASP A 311GLU A 340HIS A 417ASP A 418 | None | 0.52A | 5csyB-1h3gA:18.4 | 5csyB-1h3gA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iv8 | MALTOOLIGOSYLTREHALOSE SYNTHASE (Sulfolobusacidocaldarius) |
PF00128(Alpha-amylase)PF09196(DUF1953) | 5 | ARG A 226ASP A 228GLU A 255HIS A 442ASP A 443 | None | 0.48A | 5csyB-1iv8A:7.3 | 5csyB-1iv8A:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iv8 | MALTOOLIGOSYLTREHALOSE SYNTHASE (Sulfolobusacidocaldarius) |
PF00128(Alpha-amylase)PF09196(DUF1953) | 5 | ASP A 394ASP A 228GLU A 255HIS A 442ASP A 443 | MLY A 390 ( 3.8A)NoneNoneNoneNone | 0.84A | 5csyB-1iv8A:7.3 | 5csyB-1iv8A:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0h | NEOPULLULANASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16657(Malt_amylase_C) | 5 | ARG A 326ASP A 328GLU A 357HIS A 423ASP A 424 | None | 0.48A | 5csyB-1j0hA:19.8 | 5csyB-1j0hA:24.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jae | ALPHA-AMYLASE (Tenebriomolitor) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 5 | ARG A 183ASP A 185GLU A 222HIS A 286ASP A 287 | CL A 501 (-4.0A)NoneNoneNoneNone | 0.42A | 5csyB-1jaeA:5.0 | 5csyB-1jaeA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jxk | ALPHA-AMYLASE,SALIVARY (Homo sapiens) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 5 | ARG A 195ASP A 197GLU A 233HIS A 299ASP A 300 | CL A 493 (-4.0A)NoneNoneNoneNone | 0.38A | 5csyB-1jxkA:5.1 | 5csyB-1jxkA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcl | CYCLODEXTRINGLYCOSYLTRANSFERASE (Bacilluscirculans) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 5 | ARG A 227ASP A 229GLU A 257HIS A 327ASP A 328 | GLC A1695 ( 4.1A)GLC A1695 (-3.2A)GLC A1695 ( 2.6A)GLC A1695 (-4.1A)GLC A1695 ( 3.0A) | 0.78A | 5csyB-1kclA:19.5 | 5csyB-1kclA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lwh | 4-ALPHA-GLUCANOTRANSFERASE (Thermotogamaritima) |
PF00128(Alpha-amylase)PF09178(DUF1945) | 5 | ARG A 184ASP A 186GLU A 216HIS A 277ASP A 278 | None | 0.60A | 5csyB-1lwhA:20.4 | 5csyB-1lwhA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m53 | ISOMALTULOSESYNTHASE (Klebsiella sp.LX3) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ARG A 239ASP A 241GLU A 295HIS A 368ASP A 369 | None | 0.46A | 5csyB-1m53A:17.2 | 5csyB-1m53A:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mwo | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ARG A 196ASP A 198GLU A 222HIS A 288ASP A 289 | ZN A 441 ( 4.8A) ZN A 441 ( 4.2A) ZN A 441 (-2.0A)None ZN A 441 (-4.0A) | 0.51A | 5csyB-1mwoA:5.4 | 5csyB-1mwoA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ose | PORCINEALPHA-AMYLASE (Sus scrofa) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 5 | ARG A 195ASP A 197GLU A 233HIS A 299ASP A 300 | AC1 A 992 ( 3.7A)AC1 A 992 ( 3.3A)AC1 A 992 ( 2.7A)AC1 A 992 ( 3.9A)AC1 A 992 (-3.0A) | 0.36A | 5csyB-1oseA:5.1 | 5csyB-1oseA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qho | ALPHA-AMYLASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 5 | ARG A 226ASP A 228GLU A 256HIS A 328ASP A 329 | ABD A1200 (-3.3A)ABD A1200 (-3.1A)ABD A1200 (-2.9A)ABD A1200 (-3.8A)ABD A1200 (-2.9A) | 0.43A | 5csyB-1qhoA:19.9 | 5csyB-1qhoA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qho | ALPHA-AMYLASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 5 | ARG A 226GLU A 256GLY A 259HIS A 328ASP A 329 | ABD A1200 (-3.3A)ABD A1200 (-2.9A)ABD A1200 (-3.3A)ABD A1200 (-3.8A)ABD A1200 (-2.9A) | 0.80A | 5csyB-1qhoA:19.9 | 5csyB-1qhoA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sma | MALTOGENIC AMYLASE (Thermus sp.IM6501) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16657(Malt_amylase_C) | 5 | ARG A 326ASP A 328GLU A 357HIS A 423ASP A 424 | None | 0.61A | 5csyB-1smaA:19.5 | 5csyB-1smaA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1su7 | CARBON MONOXIDEDEHYDROGENASE 2 (Carboxydothermushydrogenoformans) |
PF03063(Prismane) | 5 | ASP A 454GLN A 453GLY A 477HIS A 522HIS A 259 | None | 1.17A | 5csyB-1su7A:undetectable | 5csyB-1su7A:21.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tz7 | 4-ALPHA-GLUCANOTRANSFERASE (Aquifexaeolicus) |
PF02446(Glyco_hydro_77) | 9 | GLN A 249ARG A 284ASP A 286GLU A 333GLY A 336PHE A 359HIS A 368HIS A 384ASP A 385 | None | 0.86A | 5csyB-1tz7A:49.4 | 5csyB-1tz7A:38.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tz7 | 4-ALPHA-GLUCANOTRANSFERASE (Aquifexaeolicus) |
PF02446(Glyco_hydro_77) | 9 | GLN A 249TRP A 251ASP A 286GLU A 333GLY A 336PHE A 359HIS A 368HIS A 384ASP A 385 | None | 0.81A | 5csyB-1tz7A:49.4 | 5csyB-1tz7A:38.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ua7 | ALPHA-AMYLASE (Bacillussubtilis) |
PF00128(Alpha-amylase) | 5 | ARG A 174ASP A 176GLU A 208HIS A 268ASP A 269 | ACI A 504 (-3.5A)ACI A 504 (-3.0A)ACI A 504 ( 2.9A)ACI A 504 (-3.8A)ACI A 504 ( 2.8A) | 0.48A | 5csyB-1ua7A:5.4 | 5csyB-1ua7A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ud3 | AMYLASE (Bacillus sp.KSM-K38) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ARG A 229ASP A 231GLU A 261HIS A 327ASP A 328 | None | 0.41A | 5csyB-1ud3A:5.2 | 5csyB-1ud3A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uok | OLIGO-1,6-GLUCOSIDASE (Bacillus cereus) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 6 | ARG A 197ASP A 199GLU A 255HIS A 283HIS A 328ASP A 329 | None | 0.92A | 5csyB-1uokA:18.2 | 5csyB-1uokA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w9x | ALPHA AMYLASE (Bacillushalmapalus) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ARG A 234ASP A 236GLU A 266HIS A 332ASP A 333 | AC1 A1492 (-3.3A)AC1 A1492 (-3.0A)AC1 A1492 (-2.8A)AC1 A1492 (-3.9A)AC1 A1492 ( 3.0A) | 0.50A | 5csyB-1w9xA:5.0 | 5csyB-1w9xA:21.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1x1n | 4-ALPHA-GLUCANOTRANSFERASE (Solanumtuberosum) |
PF02446(Glyco_hydro_77) | 7 | ARG A 319ASP A 321GLY A 371PHE A 394HIS A 404HIS A 420ASP A 421 | NoneGOL A1001 (-4.9A)GOL A1003 (-3.7A)GOL A1003 (-3.7A)GOL A1003 (-4.1A)GOL A1001 (-4.0A)GOL A1001 (-2.6A) | 1.19A | 5csyB-1x1nA:53.1 | 5csyB-1x1nA:68.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1x1n | 4-ALPHA-GLUCANOTRANSFERASE (Solanumtuberosum) |
PF02446(Glyco_hydro_77) | 5 | TRP A 286GLU A 368GLY A 371PHE A 394HIS A 404 | GOL A1002 (-3.4A)NoneGOL A1003 (-3.7A)GOL A1003 (-3.7A)GOL A1003 (-4.1A) | 0.73A | 5csyB-1x1nA:53.1 | 5csyB-1x1nA:68.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aaa | ALPHA-AMYLASE (Aspergillusniger) |
PF00128(Alpha-amylase)PF09260(DUF1966) | 5 | ARG A 204ASP A 206GLU A 230HIS A 296ASP A 297 | CA A 486 ( 4.5A) CA A 486 (-3.0A) CA A 486 (-2.5A)None CA A 486 ( 4.6A) | 0.46A | 5csyB-2aaaA:19.1 | 5csyB-2aaaA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bxy | MALTOOLIGOSYLTREHALOSE TREHALOHYDROLASE (Deinococcusradiodurans) |
PF00128(Alpha-amylase)PF02922(CBM_48)PF11941(DUF3459) | 5 | ARG A 273ASP A 275GLU A 308HIS A 399ASP A 400 | None | 0.41A | 5csyB-2bxyA:7.8 | 5csyB-2bxyA:23.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3l | GLUCAN1,4-ALPHA-MALTOHEXAOSIDASE (Bacillus sp.707) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ARG A 234ASP A 236GLU A 266HIS A 332ASP A 333 | NoneNoneNoneNoneGLC A 605 (-3.5A) | 0.58A | 5csyB-2d3lA:5.3 | 5csyB-2d3lA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e8y | AMYX PROTEIN (Bacillussubtilis) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | ARG A 404ASP A 406GLU A 435HIS A 524ASP A 525 | None | 0.54A | 5csyB-2e8yA:19.4 | 5csyB-2e8yA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pwh | SUCROSE ISOMERASE ([Pseudomonas]mesoacidophila) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 6 | ARG A 198ASP A 200GLU A 254GLY A 257HIS A 326ASP A 327 | None | 0.68A | 5csyB-2pwhA:4.0 | 5csyB-2pwhA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qps | ALPHA-AMYLASE TYPE AISOZYME (Hordeum vulgare) |
PF00128(Alpha-amylase)PF07821(Alpha-amyl_C2) | 5 | ARG A 178ASP A 180GLU A 205HIS A 290ASP A 291 | None | 0.52A | 5csyB-2qpsA:5.1 | 5csyB-2qpsA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vr5 | GLYCOGEN OPERONPROTEIN GLGX (Sulfolobussolfataricus) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C)PF02922(CBM_48) | 5 | ARG A 361ASP A 363GLU A 399HIS A 470ASP A 471 | A16 A1722 ( 3.6A)A16 A1722 (-1.8A)A16 A1722 (-4.0A)A16 A1722 (-4.0A)A16 A1722 (-3.4A) | 0.50A | 5csyB-2vr5A:6.7 | 5csyB-2vr5A:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wan | PULLULANASE (Bacillusacidopullulyticus) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | ARG A 620ASP A 622GLU A 651HIS A 735ASP A 736 | None | 0.34A | 5csyB-2wanA:19.0 | 5csyB-2wanA:20.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2x1i | 4-ALPHA-GLUCANOTRANSFERASE (Thermusbrockianus) |
PF02446(Glyco_hydro_77) | 6 | ARG A 291ASP A 293GLY A 343PHE A 366HIS A 394ASP A 395 | None | 0.89A | 5csyB-2x1iA:48.8 | 5csyB-2x1iA:37.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2x1i | 4-ALPHA-GLUCANOTRANSFERASE (Thermusbrockianus) |
PF02446(Glyco_hydro_77) | 6 | ASP A 293GLU A 340GLY A 343PHE A 366HIS A 394ASP A 395 | None | 0.93A | 5csyB-2x1iA:48.8 | 5csyB-2x1iA:37.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2x1i | 4-ALPHA-GLUCANOTRANSFERASE (Thermusbrockianus) |
PF02446(Glyco_hydro_77) | 6 | GLN A 256TRP A 258ASP A 293GLU A 340GLY A 343PHE A 366 | None | 1.18A | 5csyB-2x1iA:48.8 | 5csyB-2x1iA:37.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2x1i | 4-ALPHA-GLUCANOTRANSFERASE (Thermusbrockianus) |
PF02446(Glyco_hydro_77) | 6 | TRP A 258ASP A 293GLU A 340GLY A 343PHE A 366ASP A 395 | None | 1.11A | 5csyB-2x1iA:48.8 | 5csyB-2x1iA:37.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ya1 | PUTATIVE ALKALINEAMYLOPULLULANASE (Streptococcuspneumoniae) |
PF00128(Alpha-amylase)PF02922(CBM_48)PF03714(PUD) | 5 | ARG A 776ASP A 778GLU A 807HIS A 894ASP A 895 | NoneBGC A2144 (-2.8A)GLC A2150 ( 4.5A)NoneGLC A2150 ( 4.3A) | 0.34A | 5csyB-2ya1A:16.3 | 5csyB-2ya1A:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ya2 | PUTATIVE ALKALINEAMYLOPULLULANASE (Streptococcuspneumoniae) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | ARG A 321ASP A 323GLU A 352HIS A 439ASP A 440 | NOJ A1689 (-3.5A)NOJ A1689 (-2.8A)NOJ A1689 (-3.0A)NOJ A1689 (-3.8A)NOJ A1689 (-2.9A) | 0.29A | 5csyB-2ya2A:14.8 | 5csyB-2ya2A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yoc | PULLULANASE (Klebsiellaoxytoca) |
PF02922(CBM_48)PF03714(PUD)PF11852(DUF3372) | 5 | ARG A 663ASP A 665GLU A 694HIS A 821ASP A 822 | None | 0.83A | 5csyB-2yocA:2.9 | 5csyB-2yocA:20.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z1k | (NEO)PULLULANASE (Thermusthermophilus) |
PF00128(Alpha-amylase) | 5 | ARG A 200ASP A 202GLU A 232HIS A 314ASP A 315 | GLC A 603 (-3.4A)GLC A 603 (-2.6A)GLC A 501 ( 2.9A)GLC A 603 (-4.0A)GLC A 603 ( 2.9A) | 0.51A | 5csyB-2z1kA:4.7 | 5csyB-2z1kA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aib | GLUCOSYLTRANSFERASE-SI (Streptococcusmutans) |
PF02324(Glyco_hydro_70) | 5 | ARG A 475ASP A 477GLU A 515HIS A 587ASP A 588 | None | 0.77A | 5csyB-3aibA:2.0 | 5csyB-3aibA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3axi | OLIGO-1,6-GLUCOSIDASE IMA1 (Saccharomycescerevisiae) |
PF00128(Alpha-amylase) | 5 | ARG A 213ASP A 215HIS A 305HIS A 351ASP A 352 | GLC A 601 (-3.0A)GLC A 601 (-2.9A)NoneGLC A 601 (-3.9A)GLC A 601 (-2.8A) | 0.82A | 5csyB-3axiA:7.7 | 5csyB-3axiA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bc9 | ALPHA AMYLASE,CATALYTIC REGION (Halothermothrixorenii) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ARG A 348ASP A 350GLU A 380HIS A 446ASP A 447 | ACI A 806 (-3.3A)ACI A 806 (-3.1A)GLD A 807 ( 2.8A)ACI A 806 (-4.1A)ACI A 806 (-2.9A) | 0.35A | 5csyB-3bc9A:5.8 | 5csyB-3bc9A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bmw | CYCLOMALTODEXTRINGLUCANOTRANSFERASE (Thermoanaerobacteriumthermosulfurigenes) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 5 | ARG A 228ASP A 230GLU A 258HIS A 328ASP A 329 | ACI A 694 (-3.4A)ACI A 694 (-3.2A)G6D A 693 ( 2.8A)ACI A 694 (-3.9A)ACI A 694 ( 2.8A) | 0.47A | 5csyB-3bmwA:20.0 | 5csyB-3bmwA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dhu | ALPHA-AMYLASE (Lactobacillusplantarum) |
PF00128(Alpha-amylase) | 6 | TRP A 137ARG A 169ASP A 171GLU A 200HIS A 276ASP A 277 | None | 0.53A | 5csyB-3dhuA:23.1 | 5csyB-3dhuA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3faw | RETICULOCYTE BINDINGPROTEIN (Streptococcusagalactiae) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | ARG A 800ASP A 802GLU A 831HIS A 918ASP A 919 | None | 0.93A | 5csyB-3fawA:16.0 | 5csyB-3fawA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gbd | SUCROSE ISOMERASESMUA FROMPROTAMINOBACTERRUBRUM (Serratiaplymuthica) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ARG A 212ASP A 214GLU A 268HIS A 341ASP A 342 | NoneEDO A8003 ( 2.7A)EDO A8001 (-3.1A)NoneEDO A8002 ( 3.5A) | 0.47A | 5csyB-3gbdA:17.5 | 5csyB-3gbdA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hje | 704AA LONGHYPOTHETICALGLYCOSYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00128(Alpha-amylase)PF09196(DUF1953) | 6 | ASP A 392ARG A 220ASP A 222GLU A 249HIS A 440ASP A 441 | NoneNoneGOL A 802 (-2.8A)GOL A 804 (-3.8A)NoneGOL A 802 ( 3.7A) | 0.88A | 5csyB-3hjeA:13.2 | 5csyB-3hjeA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k8k | ALPHA-AMYLASE, SUSG (Bacteroidesthetaiotaomicron) |
PF00128(Alpha-amylase) | 5 | ARG A 386ASP A 388GLU A 431HIS A 497ASP A 498 | NoneACT A 961 (-2.8A)ACT A 961 ( 4.3A)NoneEDO A 901 (-4.4A) | 0.51A | 5csyB-3k8kA:4.8 | 5csyB-3k8kA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m07 | PUTATIVE ALPHAAMYLASE (Salmonellaenterica) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | TRP A 227ARG A 259ASP A 261GLU A 296ASP A 393 | BTB A 605 (-3.1A)NoneBTB A 605 (-2.9A) MG A 597 (-3.9A)BTB A 605 (-4.1A) | 1.06A | 5csyB-3m07A:19.8 | 5csyB-3m07A:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m07 | PUTATIVE ALPHAAMYLASE (Salmonellaenterica) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | TRP A 227ARG A 259ASP A 261GLU A 296HIS A 392 | BTB A 605 (-3.1A)NoneBTB A 605 (-2.9A) MG A 597 (-3.9A)BTB A 605 (-4.1A) | 0.62A | 5csyB-3m07A:19.8 | 5csyB-3m07A:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgv | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ARG A 196ASP A 198GLU A 222HIS A 288ASP A 289 | TRS A 505 (-3.0A)TRS A 505 (-2.7A)TRS A 505 (-2.7A)TRS A 505 (-4.2A)TRS A 505 (-3.0A) | 0.49A | 5csyB-3qgvA:5.4 | 5csyB-3qgvA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ucq | AMYLOSUCRASE (Deinococcusgeothermalis) |
PF00128(Alpha-amylase) | 5 | ARG A 282ASP A 284GLU A 326HIS A 395ASP A 396 | GOL A 721 (-3.4A)GOL A 720 (-3.0A)TRS A 700 (-4.2A)GOL A 721 (-4.6A)TRS A 700 (-3.1A) | 0.29A | 5csyB-3ucqA:18.4 | 5csyB-3ucqA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vgf | MALTO-OLIGOSYLTREHALOSE TREHALOHYDROLASE (Sulfolobussolfataricus) |
PF00128(Alpha-amylase)PF09071(Alpha-amyl_C) | 5 | TRP A 215ARG A 250GLU A 283HIS A 376ASP A 377 | GLC A 604 (-3.3A)GLC A 604 (-3.1A)GLC A 604 (-2.6A)GLC A 604 (-4.0A)GLC A 604 (-2.7A) | 0.59A | 5csyB-3vgfA:18.0 | 5csyB-3vgfA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vm5 | ALPHA-AMYLASE (Oryzias latipes) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 5 | ARG A 195ASP A 197GLU A 233HIS A 299ASP A 300 | CL A 507 (-3.9A)NoneNoneNoneNone | 0.45A | 5csyB-3vm5A:5.3 | 5csyB-3vm5A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vm7 | ALPHA-AMYLASE (Malbrancheacinnamomea) |
PF00128(Alpha-amylase)PF09260(DUF1966) | 5 | ARG A 223ASP A 225GLU A 249HIS A 315ASP A 316 | NoneGLC A 503 (-3.5A)GLC A 503 (-2.6A)NoneGLC A 503 (-3.0A) | 0.45A | 5csyB-3vm7A:19.6 | 5csyB-3vm7A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vtr | N-ACETYLGLUCOSAMINIDASE (Ostriniafurnacalis) |
PF00728(Glyco_hydro_20)PF14845(Glycohydro_20b2) | 5 | LEU A 334ARG A 220GLY A 332HIS A 246ASP A 299 | NoneTCG A 601 (-2.7A)NoneNoneNone | 1.03A | 5csyB-3vtrA:11.0 | 5csyB-3vtrA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wdj | TYPE I PULLULANASE (Anoxybacillussp. LM18-11) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | ARG A 411ASP A 413GLU A 442HIS A 525ASP A 526 | MTT A 802 (-3.4A)MTT A 802 (-2.8A)MTT A 802 (-3.0A)MTT A 802 (-3.9A)MTT A 802 (-2.9A) | 0.31A | 5csyB-3wdjA:17.6 | 5csyB-3wdjA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wn6 | ALPHA-AMYLASE (Oryza sativa) |
PF00128(Alpha-amylase)PF07821(Alpha-amyl_C2) | 5 | ARG A 201ASP A 203GLU A 228HIS A 313ASP A 314 | NoneGOL A 505 (-3.4A)NoneGOL A 505 (-4.3A)GOL A 505 (-2.9A) | 0.41A | 5csyB-3wn6A:4.3 | 5csyB-3wn6A:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wy2 | ALPHA-GLUCOSIDASE (Halomonas sp.H11) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | ARG A 200ASP A 202GLU A 271GLY A 228HIS A 332 | BGC A 605 (-3.0A)BGC A 605 (-2.4A)BGC A 605 (-3.3A)NoneBGC A 605 (-3.9A) | 1.08A | 5csyB-3wy2A:17.5 | 5csyB-3wy2A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wy2 | ALPHA-GLUCOSIDASE (Halomonas sp.H11) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | ARG A 200ASP A 202GLU A 271HIS A 332ASP A 333 | BGC A 605 (-3.0A)BGC A 605 (-2.4A)BGC A 605 (-3.3A)BGC A 605 (-3.9A)BGC A 605 (-2.9A) | 0.46A | 5csyB-3wy2A:17.5 | 5csyB-3wy2A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wy2 | ALPHA-GLUCOSIDASE (Halomonas sp.H11) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | ARG A 200ASP A 202GLY A 273HIS A 332ASP A 333 | BGC A 605 (-3.0A)BGC A 605 (-2.4A)NoneBGC A 605 (-3.9A)BGC A 605 (-2.9A) | 0.69A | 5csyB-3wy2A:17.5 | 5csyB-3wy2A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aee | ALPHA AMYLASE,CATALYTIC REGION (Staphylothermusmarinus) |
PF00128(Alpha-amylase) | 5 | ARG A 440ASP A 442GLU A 471HIS A 535ASP A 536 | None | 0.42A | 5csyB-4aeeA:2.1 | 5csyB-4aeeA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aef | NEOPULLULANASE(ALPHA-AMYLASE II) (Pyrococcusfuriosus) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16561(AMPK1_CBM) | 5 | ARG A 409ASP A 411GLU A 437HIS A 501ASP A 502 | None | 0.48A | 5csyB-4aefA:3.9 | 5csyB-4aefA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aie | GLUCAN1,6-ALPHA-GLUCOSIDASE (Lactobacillusacidophilus) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ARG A 196ASP A 198GLU A 240HIS A 315ASP A 316 | GOL A1542 ( 4.4A)GOL A1542 (-2.7A)GOL A1542 ( 3.6A)NoneGOL A1548 (-3.5A) | 0.35A | 5csyB-4aieA:4.1 | 5csyB-4aieA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aio | LIMIT DEXTRINASE (Hordeum vulgare) |
PF02922(CBM_48)PF11852(DUF3372) | 5 | ARG A 471ASP A 473GLU A 510HIS A 641ASP A 642 | NoneGOL A1888 (-3.0A)GOL A1888 ( 4.9A)NoneNone | 0.70A | 5csyB-4aioA:5.1 | 5csyB-4aioA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ays | AMYLOSUCRASE (Deinococcusradiodurans) |
PF00128(Alpha-amylase) | 5 | ARG A 274ASP A 276GLU A 318HIS A 387ASP A 388 | None | 0.85A | 5csyB-4aysA:13.8 | 5csyB-4aysA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e2o | ALPHA-AMYLASE (Geobacillusthermoleovorans) |
PF00128(Alpha-amylase) | 5 | ARG A 215ASP A 217GLU A 246HIS A 313ASP A 314 | ACI A 505 (-3.3A)ACI A 505 (-3.1A)G6D A 506 (-2.7A)ACI A 505 (-3.7A)ACI A 505 (-2.8A) | 0.41A | 5csyB-4e2oA:6.0 | 5csyB-4e2oA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m8u | OLIGO-1,6-GLUCOSIDASE 1 (Bacillussubtilis) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 6 | ARG A 197ASP A 199GLU A 255HIS A 283HIS A 331ASP A 332 | TRS A 601 ( 4.8A)TRS A 601 (-2.7A)TRS A 601 ( 2.7A)GOL A 606 (-3.8A)NoneGOL A 602 (-2.8A) | 0.88A | 5csyB-4m8uA:17.3 | 5csyB-4m8uA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4okd | ISOAMYLASE (Chlamydomonasreinhardtii) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | ARG A 450ASP A 452GLU A 527HIS A 619ASP A 620 | GLC A1001 (-3.3A)GLC A1001 (-2.0A)GLC A1001 (-3.2A)GLC A1001 (-4.0A)GLC A1001 (-2.7A) | 0.47A | 5csyB-4okdA:17.6 | 5csyB-4okdA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3p | 4-ALPHA-GLUCANOTRANSFERASE (Escherichiacoli) |
PF02446(Glyco_hydro_77) | 6 | ARG A 446ASP A 448GLU A 496GLY A 499PHE A 522HIS A 547 | None | 0.95A | 5csyB-4s3pA:32.4 | 5csyB-4s3pA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3p | 4-ALPHA-GLUCANOTRANSFERASE (Escherichiacoli) |
PF02446(Glyco_hydro_77) | 5 | ARG A 446ASP A 448PHE A 522HIS A 547ASP A 548 | None | 0.89A | 5csyB-4s3pA:32.4 | 5csyB-4s3pA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3p | 4-ALPHA-GLUCANOTRANSFERASE (Escherichiacoli) |
PF02446(Glyco_hydro_77) | 5 | GLN A 411TRP A 413GLU A 496GLY A 499PHE A 522 | None | 0.75A | 5csyB-4s3pA:32.4 | 5csyB-4s3pA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3p | 4-ALPHA-GLUCANOTRANSFERASE (Escherichiacoli) |
PF02446(Glyco_hydro_77) | 6 | TRP A 413ARG A 446GLU A 496GLY A 499PHE A 522HIS A 547 | None | 0.79A | 5csyB-4s3pA:32.4 | 5csyB-4s3pA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3p | 4-ALPHA-GLUCANOTRANSFERASE (Escherichiacoli) |
PF02446(Glyco_hydro_77) | 5 | TRP A 413ARG A 446PHE A 522HIS A 547ASP A 548 | None | 0.87A | 5csyB-4s3pA:32.4 | 5csyB-4s3pA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvc | DEXTRANSUCRASE (Leuconostocmesenteroides) |
PF02324(Glyco_hydro_70) | 5 | ARG A2208ASP A2210GLU A2248HIS A2321ASP A2322 | NoneGOL A3008 (-2.7A)GOL A3008 ( 4.5A)NoneNone | 0.79A | 5csyB-4tvcA:3.2 | 5csyB-4tvcA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uzu | ALPHA-AMYLASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ARG A 230ASP A 232GLU A 262HIS A 328ASP A 329 | NA A1490 ( 4.1A) NA A1490 (-2.9A) NA A1490 (-2.7A)None NA A1490 ( 4.5A) | 0.49A | 5csyB-4uzuA:5.0 | 5csyB-4uzuA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xb3 | GLUCAN1,6-ALPHA-GLUCOSIDASE (Streptococcusmutans) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ARG A 192ASP A 194HIS A 264HIS A 312ASP A 313 | None | 0.81A | 5csyB-4xb3A:20.0 | 5csyB-4xb3A:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a2a | APO FORM OFANOXYBACILLUSALPHA-AMYLASES (Anoxybacillusayderensis) |
PF00128(Alpha-amylase) | 5 | ARG A 211ASP A 213GLU A 242HIS A 309ASP A 310 | ACT A1479 ( 4.9A)ACT A1479 (-2.6A)ACT A1479 ( 4.5A)NoneACT A1479 ( 4.9A) | 0.46A | 5csyB-5a2aA:5.9 | 5csyB-5a2aA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5brq | GLYCOSIDE HYDROLASEFAMILY 13 (Bacilluslicheniformis) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ARG A 201ASP A 203GLU A 254HIS A 282HIS A 328 | None | 1.13A | 5csyB-5brqA:17.0 | 5csyB-5brqA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5brq | GLYCOSIDE HYDROLASEFAMILY 13 (Bacilluslicheniformis) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ASP A 203GLU A 254HIS A 282HIS A 328ASP A 329 | None | 0.95A | 5csyB-5brqA:17.0 | 5csyB-5brqA:21.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5csu | 4-ALPHA-GLUCANOTRANSFERASE DPE1,CHLOROPLASTIC/AMYLOPLASTIC (Arabidopsisthaliana) |
PF02446(Glyco_hydro_77) | 12 | ASP A 329LEU A 330GLN A 336TRP A 338ARG A 371ASP A 373GLU A 420GLY A 423PHE A 446HIS A 456HIS A 472ASP A 473 | GLC A 608 ( 3.5A)BGC A 609 ( 3.6A)AGL A 607 ( 3.6A)HMC A 606 ( 3.6A)HMC A 606 ( 3.7A)HMC A 606 ( 3.0A)AGL A 607 ( 2.7A)GLC A 608 ( 3.6A)BGC A 609 ( 4.1A)BGC A 609 ( 4.3A)HMC A 606 ( 3.8A)HMC A 606 ( 2.8A) | 0.31A | 5csyB-5csuA:60.3 | 5csyB-5csuA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d0f | UNCHARACTERIZEDPROTEIN ([Candida]glabrata) |
PF06202(GDE_C)PF14699(hGDE_N)PF14701(hDGE_amylase)PF14702(hGDE_central) | 5 | TRP A 496ARG A 533ASP A 535HIS A 669ASP A 670 | MTT A2001 (-3.5A)NoneMTT A2001 (-3.0A)NoneMTT A2001 (-3.3A) | 0.80A | 5csyB-5d0fA:11.6 | 5csyB-5d0fA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5do8 | LMO0184 PROTEIN (Listeriamonocytogenes) |
no annotation | 6 | ARG B 195ASP B 197GLU B 254HIS B 282HIS B 327ASP B 328 | BGC B 601 (-3.4A)BGC B 601 (-3.7A)BGC B 601 ( 2.7A)NoneBGC B 601 (-3.9A)BGC B 601 ( 2.8A) | 1.27A | 5csyB-5do8B:17.2 | 5csyB-5do8B:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbe | INACTIVEGLUCANSUCRASE (Lactobacillusreuteri) |
PF02324(Glyco_hydro_70) | 5 | ARG A1013ASP A1015GLU A1053HIS A1124ASP A1125 | NoneNoneNoneNoneGLC A1711 ( 3.2A) | 0.38A | 5csyB-5jbeA:3.0 | 5csyB-5jbeA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jjh | 4-ALPHA-GLUCANOTRANSFERASE (Corynebacteriumglutamicum) |
PF02446(Glyco_hydro_77) | 5 | ARG A 458ASP A 460GLU A 508PHE A 534HIS A 560 | None | 1.15A | 5csyB-5jjhA:32.3 | 5csyB-5jjhA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jjh | 4-ALPHA-GLUCANOTRANSFERASE (Corynebacteriumglutamicum) |
PF02446(Glyco_hydro_77) | 5 | ARG A 458ASP A 460PHE A 534HIS A 560ASP A 561 | None | 0.68A | 5csyB-5jjhA:32.3 | 5csyB-5jjhA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m99 | ALPHA-AMYLASE (Thermotogapetrophila) |
PF00128(Alpha-amylase) | 5 | ARG B 211ASP B 213GLU B 253HIS B 304ASP B 305 | K B 605 ( 4.8A)EDO B 616 ( 2.8A) K B 605 ( 4.7A)None K B 605 ( 4.7A) | 0.45A | 5csyB-5m99B:18.7 | 5csyB-5m99B:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6v | AMYLOSUCRASE (Neisseriapolysaccharea) |
no annotation | 5 | ARG A 284ASP A 286GLU A 328HIS A 392ASP A 393 | TRS A 701 ( 4.6A)TRS A 701 (-2.8A)TRS A 701 (-2.8A)NoneTRS A 701 ( 4.6A) | 0.44A | 5csyB-5n6vA:14.9 | 5csyB-5n6vA:9.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ot1 | PULLULANASE TYPE II,GH13 FAMILY (Thermococcuskodakarensis) |
no annotation | 5 | ARG A 501ASP A 503GLU A 534HIS A 600ASP A 601 | None | 0.42A | 5csyB-5ot1A:19.6 | 5csyB-5ot1A:10.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ww1 | PULULLANASE (Paenibacillusbarengoltzii) |
no annotation | 5 | ARG A 371ASP A 373GLU A 402HIS A 492ASP A 493 | NoneNoneGLC A 701 ( 4.8A)NoneGLC A 701 ( 4.6A) | 0.31A | 5csyB-5ww1A:4.2 | 5csyB-5ww1A:9.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7u | TREHALOSE SYNTHASE (Thermobaculumterrenum) |
no annotation | 5 | ARG A 200ASP A 202GLU A 244HIS A 309ASP A 310 | TRS A 600 ( 4.8A)TRS A 600 (-2.8A)TRS A 600 (-2.7A)NoneTRS A 600 ( 4.7A) | 0.38A | 5csyB-5x7uA:17.0 | 5csyB-5x7uA:8.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z0u | NEOPULLULANASE 1 (Thermoactinomycesvulgaris) |
no annotation | 5 | ARG A 354ASP A 356GLU A 396HIS A 471ASP A 472 | None | 0.45A | 5csyB-5z0uA:19.8 | 5csyB-5z0uA:10.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1edy | ALPHA1-MACROGLOBULIN (Rattusnorvegicus) |
PF07677(A2M_recep) | 4 | TYR A 128PHE A 17HIS A 29PRO A 131 | None | 1.30A | 5csyB-1edyA:undetectable | 5csyB-1edyA:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h0p | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE5 (Caenorhabditiselegans) |
PF00160(Pro_isomerase) | 4 | PHE A 49HIS A 116LEU A 122PRO A 24 | None | 1.41A | 5csyB-1h0pA:undetectable | 5csyB-1h0pA:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ioo | SF11-RNASE (Nicotiana alata) |
PF00445(Ribonuclease_T2) | 4 | PHE A 194HIS A 124LEU A 117PRO A 128 | None | 1.49A | 5csyB-1iooA:undetectable | 5csyB-1iooA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itu | RENAL DIPEPTIDASE (Homo sapiens) |
PF01244(Peptidase_M19) | 4 | TYR A 305PHE A 113LEU A 330PRO A 15 | None | 1.46A | 5csyB-1ituA:3.6 | 5csyB-1ituA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j5s | URONATE ISOMERASE (Thermotogamaritima) |
PF02614(UxaC) | 4 | PHE A 449HIS A 439LEU A 391PRO A 29 | None | 1.44A | 5csyB-1j5sA:4.6 | 5csyB-1j5sA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k26 | NUDIX HOMOLOG (Pyrobaculumaerophilum) |
PF00293(NUDIX) | 4 | TYR A 25PHE A 46LEU A 105PRO A 28 | None | 1.44A | 5csyB-1k26A:undetectable | 5csyB-1k26A:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5a | AMIDE SYNTHASE (Vibrio cholerae) |
PF00668(Condensation) | 4 | PHE A 158HIS A 108LEU A 141PRO A 272 | None | 1.27A | 5csyB-1l5aA:undetectable | 5csyB-1l5aA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lw7 | TRANSCRIPTIONALREGULATOR NADR (Haemophilusinfluenzae) |
PF01467(CTP_transf_like)PF13521(AAA_28) | 4 | TYR A 181PHE A 165LEU A 137PRO A 167 | None | 1.43A | 5csyB-1lw7A:undetectable | 5csyB-1lw7A:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mwo | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 4 | TYR A 306PHE A 279HIS A 333PRO A 278 | None | 1.14A | 5csyB-1mwoA:5.4 | 5csyB-1mwoA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1na6 | RESTRICTIONENDONUCLEASE ECORII (Escherichiacoli) |
PF09019(EcoRII-C)PF09217(EcoRII-N) | 4 | TYR A 202PHE A 193LEU A 231PRO A 194 | None | 1.38A | 5csyB-1na6A:2.6 | 5csyB-1na6A:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nx8 | CARBAPENEM SYNTHASE (Pectobacteriumcarotovorum) |
PF02668(TauD) | 4 | TYR A 230PHE A 192HIS A 135LEU A 150 | None | 1.29A | 5csyB-1nx8A:undetectable | 5csyB-1nx8A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p2z | HEXON PROTEIN (HumanmastadenovirusC) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 4 | PHE A 960HIS A 914LEU A 916PRO A 959 | None | 1.23A | 5csyB-1p2zA:undetectable | 5csyB-1p2zA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qu2 | ISOLEUCYL-TRNASYNTHETASE (Staphylococcusaureus) |
PF00133(tRNA-synt_1)PF06827(zf-FPG_IleRS)PF08264(Anticodon_1) | 4 | PHE A 148HIS A 67LEU A 142PRO A 92 | NoneMRC A1993 (-4.1A)NoneNone | 1.49A | 5csyB-1qu2A:undetectable | 5csyB-1qu2A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1txl | METAL-BINDINGPROTEIN YODA (Escherichiacoli) |
PF09223(ZinT) | 4 | TYR A 95PHE A 89HIS A 97LEU A 73 | None | 1.47A | 5csyB-1txlA:undetectable | 5csyB-1txlA:17.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tz7 | 4-ALPHA-GLUCANOTRANSFERASE (Aquifexaeolicus) |
PF02446(Glyco_hydro_77) | 4 | TYR A 58HIS A 287LEU A 335PRO A 452 | None | 0.50A | 5csyB-1tz7A:49.4 | 5csyB-1tz7A:38.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ua4 | ADP-DEPENDENTGLUCOKINASE (Pyrococcusfuriosus) |
PF04587(ADP_PFK_GK) | 4 | PHE A 144HIS A 132LEU A 27PRO A 164 | None | 1.37A | 5csyB-1ua4A:2.4 | 5csyB-1ua4A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ufa | TT1467 PROTEIN (Thermusthermophilus) |
PF03065(Glyco_hydro_57)PF09210(DUF1957) | 4 | TYR A 421PHE A 486HIS A 481LEU A 453 | None | 1.32A | 5csyB-1ufaA:3.2 | 5csyB-1ufaA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wl7 | ARABINANASE-TS (Geobacillusthermodenitrificans) |
PF04616(Glyco_hydro_43) | 4 | TYR A 74PHE A 64LEU A 113PRO A 68 | None | 0.98A | 5csyB-1wl7A:undetectable | 5csyB-1wl7A:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xea | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Vibrio cholerae) |
PF01408(GFO_IDH_MocA) | 4 | PHE A 168HIS A 296LEU A 298PRO A 171 | None | 1.32A | 5csyB-1xeaA:undetectable | 5csyB-1xeaA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2au1 | IGG-DEGRADINGPROTEASE (Streptococcuspyogenes) |
PF09028(Mac-1) | 4 | PHE A 326HIS A 253LEU A 323PRO A 173 | None | 1.42A | 5csyB-2au1A:undetectable | 5csyB-2au1A:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gdu | SUCROSEPHOSPHORYLASE (Bifidobacteriumadolescentis) |
PF00128(Alpha-amylase)PF09244(DUF1964) | 4 | TYR A 196PHE A 140LEU A 113PRO A 139 | None | 1.49A | 5csyB-2gduA:16.4 | 5csyB-2gduA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j7n | RNA-DEPENDENT RNAPOLYMERASE (Neurosporacrassa) |
PF05183(RdRP) | 4 | TYR A 890PHE A 841LEU A 898PRO A 885 | None | 1.39A | 5csyB-2j7nA:undetectable | 5csyB-2j7nA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obe | HEXON (HumanmastadenovirusE) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 4 | PHE A 925HIS A 879LEU A 881PRO A 924 | None | 1.29A | 5csyB-2obeA:undetectable | 5csyB-2obeA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og2 | PUTATIVE SIGNALRECOGNITION PARTICLERECEPTOR (Arabidopsisthaliana) |
PF00448(SRP54)PF02881(SRP54_N) | 4 | PHE A 304HIS A 148LEU A 150PRO A 316 | None | 1.28A | 5csyB-2og2A:2.2 | 5csyB-2og2A:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vyc | BIODEGRADATIVEARGININEDECARBOXYLASE (Escherichiacoli) |
PF01276(OKR_DC_1)PF03709(OKR_DC_1_N)PF03711(OKR_DC_1_C) | 4 | PHE A 521HIS A 363LEU A 531PRO A 284 | None | 1.44A | 5csyB-2vycA:undetectable | 5csyB-2vycA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsk | GLYCOGEN DEBRANCHINGENZYME (Escherichiacoli) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 4 | PHE A 550HIS A 556LEU A 504PRO A 632 | None | 1.41A | 5csyB-2wskA:18.5 | 5csyB-2wskA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwu | DNA-3-METHYLADENINEGLYCOSYLASE 2 (Escherichiacoli) |
PF00730(HhH-GPD)PF06029(AlkA_N) | 4 | PHE A 18HIS A 270LEU A 268PRO A 108 | None | 1.49A | 5csyB-3cwuA:undetectable | 5csyB-3cwuA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3a | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF01301(Glyco_hydro_35) | 4 | PHE A 512HIS A 385LEU A 383PRO A 507 | None | 1.37A | 5csyB-3d3aA:9.7 | 5csyB-3d3aA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3edp | LIN2111 PROTEIN (Listeriainnocua) |
PF00392(GntR)PF07702(UTRA) | 4 | TYR A 69PHE A 101LEU A 150PRO A 72 | None | 1.45A | 5csyB-3edpA:undetectable | 5csyB-3edpA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fn1 | NEDD8-CONJUGATINGENZYME UBE2F (Homo sapiens) |
PF00179(UQ_con) | 4 | TYR B 75HIS B 164LEU B 166PRO B 107 | None | 1.30A | 5csyB-3fn1B:undetectable | 5csyB-3fn1B:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbj | FLAVONOID3-O-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 4 | PHE A 239HIS A 155LEU A 153PRO A 214 | None | 1.45A | 5csyB-3hbjA:undetectable | 5csyB-3hbjA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k65 | PROTHROMBIN (Homo sapiens) |
PF00051(Kringle) | 4 | TYR A 242PHE A 208LEU A 202PRO A 222 | NoneNoneBU1 A 599 ( 4.7A)None | 1.43A | 5csyB-3k65A:undetectable | 5csyB-3k65A:12.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nby | SNURPORTIN-1 (Homo sapiens) |
PF11538(Snurportin1) | 4 | TYR B 265HIS B 264LEU B 55PRO B 194 | None | 1.43A | 5csyB-3nbyB:undetectable | 5csyB-3nbyB:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3q | ALKALINE PHOSPHATASE (Sphingomonassp. BSAR-1) |
PF01663(Phosphodiest) | 4 | PHE A 51HIS A 93LEU A 296PRO A 502 | None | 1.29A | 5csyB-3q3qA:undetectable | 5csyB-3q3qA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmv | GLYCOGENIN-1 (Homo sapiens) |
PF01501(Glyco_transf_8) | 4 | TYR A 224PHE A 213LEU A 248PRO A 219 | None | 1.47A | 5csyB-3rmvA:undetectable | 5csyB-3rmvA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rv6 | ISOCHORISMATESYNTHASE/ISOCHORISMATE-PYRUVATE LYASEMBTI (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind) | 4 | PHE A 112HIS A 117LEU A 121PRO A 358 | None | 1.09A | 5csyB-3rv6A:undetectable | 5csyB-3rv6A:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3to3 | PETROBACTINBIOSYNTHESIS PROTEINASBB (Bacillusanthracis) |
PF04183(IucA_IucC)PF06276(FhuF) | 4 | TYR A 560PHE A 75LEU A 509PRO A 588 | None | 1.35A | 5csyB-3to3A:undetectable | 5csyB-3to3A:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0a | NTNH (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 4 | TYR B 372PHE B 78LEU B 86PRO B 205 | None | 1.41A | 5csyB-3v0aB:undetectable | 5csyB-3v0aB:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vuo | NTNHA (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 4 | TYR A 372PHE A 78LEU A 86PRO A 205 | None | 1.47A | 5csyB-3vuoA:undetectable | 5csyB-3vuoA:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zif | HEXON PROTEIN (BovinemastadenovirusB) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 4 | PHE A 904HIS A 858LEU A 860PRO A 903 | None | 1.39A | 5csyB-3zifA:undetectable | 5csyB-3zifA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zzu | ELONGATION FACTOR G (Staphylococcusaureus) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF14492(EFG_II) | 4 | TYR A 186PHE A 144LEU A 257PRO A 165 | None | 1.37A | 5csyB-3zzuA:undetectable | 5csyB-3zzuA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8s | ADP-DEPENDENTGLUCOKINASE (Thermococcuslitoralis) |
PF04587(ADP_PFK_GK) | 4 | PHE A 152HIS A 140LEU A 35PRO A 172 | None | 1.37A | 5csyB-4b8sA:undetectable | 5csyB-4b8sA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ds2 | UBIQUITIN-CONJUGATING ENZYME E2,PUTATIVE (Trypanosomacruzi) |
PF00179(UQ_con) | 4 | PHE A 73HIS A 115LEU A 16PRO A 82 | None | 1.02A | 5csyB-4ds2A:undetectable | 5csyB-4ds2A:13.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ejr | MAJOR CAPSID PROTEINVP60 (Rabbithemorrhagicdisease virus) |
PF00915(Calici_coat) | 4 | TYR A 73PHE A 221LEU A 106PRO A 217 | None | 1.40A | 5csyB-4ejrA:undetectable | 5csyB-4ejrA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gc5 | DIMETHYLADENOSINETRANSFERASE 1,MITOCHONDRIAL (Mus musculus) |
PF00398(RrnaAD) | 4 | PHE A 165HIS A 137LEU A 230PRO A 164 | None | 1.22A | 5csyB-4gc5A:undetectable | 5csyB-4gc5A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i9c | RESPONSE REGULATORASPARTATEPHOSPHATASE F (Bacillussubtilis) |
PF12895(ANAPC3)PF13424(TPR_12) | 4 | TYR A 18PHE A 24HIS A 60LEU A 62 | None | 1.24A | 5csyB-4i9cA:undetectable | 5csyB-4i9cA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ka8 | OLIGOPEPTIDASE A (Arabidopsisthaliana) |
PF01432(Peptidase_M3) | 4 | TYR A 504PHE A 573HIS A 579LEU A 581 | GOL A 804 (-4.7A)NoneNoneNone | 1.43A | 5csyB-4ka8A:undetectable | 5csyB-4ka8A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kqb | PROTEIN H03A11.1 (Caenorhabditiselegans) |
PF06702(Fam20C) | 4 | TYR A 147PHE A 373HIS A 385LEU A 386 | NoneNoneNoneADP A 608 ( 4.6A) | 1.39A | 5csyB-4kqbA:undetectable | 5csyB-4kqbA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kqn | D-HYDANTOINASE (Bacillus sp.AR9) |
PF01979(Amidohydro_1) | 4 | TYR A 210HIS A 208LEU A 291PRO A 214 | TYR A 210 ( 1.3A)HIS A 208 ( 1.0A)LEU A 291 ( 0.6A)PRO A 214 ( 1.1A) | 1.18A | 5csyB-4kqnA:3.6 | 5csyB-4kqnA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nrh | CHAPERONE SYCD (Chlamydiapneumoniae) |
PF07720(TPR_3) | 4 | TYR B 28PHE B 86LEU B 40PRO B 85 | None | 1.40A | 5csyB-4nrhB:undetectable | 5csyB-4nrhB:15.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p2b | GLUTAMINEAMINOACYL-TRNASYNTHETASE (Toxoplasmagondii) |
PF00749(tRNA-synt_1c)PF03950(tRNA-synt_1c_C) | 4 | TYR A 91PHE A 45LEU A 306PRO A 47 | None | 1.14A | 5csyB-4p2bA:2.6 | 5csyB-4p2bA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s1j | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Leishmaniadonovani) |
PF00160(Pro_isomerase) | 4 | PHE A 48HIS A 115LEU A 120PRO A 23 | None | 1.34A | 5csyB-4s1jA:undetectable | 5csyB-4s1jA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ymk | ACYL-COA DESATURASE1 (Mus musculus) |
PF00487(FA_desaturase) | 4 | TYR A 269PHE A 293HIS A 352LEU A 358 | None | 1.15A | 5csyB-4ymkA:undetectable | 5csyB-4ymkA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypt | REPLICASEPOLYPROTEIN 1AB (Murinecoronavirus) |
PF08715(Viral_protease) | 4 | TYR A1874PHE A1709HIS A1876LEU A1725 | None | 1.13A | 5csyB-4yptA:undetectable | 5csyB-4yptA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zg7 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 2 (Homo sapiens) |
PF01033(Somatomedin_B)PF01223(Endonuclease_NS)PF01663(Phosphodiest) | 4 | PHE A 161HIS A 349LEU A 346PRO A 165 | None | 0.76A | 5csyB-4zg7A:undetectable | 5csyB-4zg7A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5co8 | NUCLEASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF00752(XPG_N)PF00867(XPG_I) | 4 | PHE A 295HIS A 25LEU A 35PRO A 296 | None | 1.25A | 5csyB-5co8A:undetectable | 5csyB-5co8A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cs0 | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF08326(ACC_central) | 4 | PHE A 876HIS A 912LEU A 907PRO A 877 | None | 1.43A | 5csyB-5cs0A:undetectable | 5csyB-5cs0A:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5csa | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF00364(Biotin_lipoyl)PF08326(ACC_central) | 4 | PHE A 876HIS A 912LEU A 907PRO A 877 | None | 1.47A | 5csyB-5csaA:undetectable | 5csyB-5csaA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5csl | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF01039(Carboxyl_trans)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2)PF08326(ACC_central) | 4 | PHE A 876HIS A 912LEU A 907PRO A 877 | None | 1.40A | 5csyB-5cslA:undetectable | 5csyB-5cslA:13.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5csu | 4-ALPHA-GLUCANOTRANSFERASE DPE1,CHLOROPLASTIC/AMYLOPLASTIC (Arabidopsisthaliana) |
PF02446(Glyco_hydro_77) | 5 | TYR A 136PHE A 331HIS A 374LEU A 422PRO A 539 | HMC A 606 ( 4.0A)GLC A 608 ( 4.7A)AGL A 607 ( 3.8A)GLC A 608 ( 3.8A)GLC A 605 ( 3.6A) | 0.13A | 5csyB-5csuA:60.3 | 5csyB-5csuA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dkv | ABC TRANSPORTERSUBSTRATE BINDINGPROTEIN (RIBOSE) (Agrobacteriumvitis) |
PF13407(Peripla_BP_4) | 4 | TYR A 142PHE A 138LEU A 103PRO A 139 | None | 1.40A | 5csyB-5dkvA:undetectable | 5csyB-5dkvA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fv4 | CARBOXYLIC ESTERHYDROLASE (Sus scrofa) |
PF00135(COesterase) | 4 | PHE A 454HIS A 449LEU A 83PRO A 434 | None | 1.16A | 5csyB-5fv4A:undetectable | 5csyB-5fv4A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fx8 | LINOLEATE11-LIPOXYGENASE (Gaeumannomycesavenae) |
PF00305(Lipoxygenase) | 4 | TYR A 289PHE A 397HIS A 478PRO A 173 | NoneNone MN A1000 (-3.4A)None | 1.22A | 5csyB-5fx8A:undetectable | 5csyB-5fx8A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5t | ARGONAUTE (Methanocaldococcusjannaschii) |
PF02171(Piwi) | 4 | TYR A 677PHE A 622HIS A 685PRO A 624 | None | 1.41A | 5csyB-5g5tA:undetectable | 5csyB-5g5tA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hvo | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Aspergillusfumigatus) |
PF00982(Glyco_transf_20) | 4 | PHE A 182HIS A 224LEU A 225PRO A 183 | None | 1.40A | 5csyB-5hvoA:undetectable | 5csyB-5hvoA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6e | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF08326(ACC_central) | 4 | PHE A 876HIS A 912LEU A 907PRO A 877 | None | 1.46A | 5csyB-5i6eA:undetectable | 5csyB-5i6eA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikz | OXALATE BIOSYNTHETICCOMPONENT 1 (Burkholderiathailandensis) |
PF05853(BKACE) | 4 | PHE A 456HIS A 421LEU A 412PRO A 455 | None | 1.36A | 5csyB-5ikzA:4.7 | 5csyB-5ikzA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j62 | PUTATIVE REDUCTASE (Clostridioidesdifficile) |
PF00881(Nitroreductase) | 4 | TYR A 185PHE A 189LEU A 114PRO A 188 | NoneFMN A 301 ( 4.8A)NoneNone | 1.39A | 5csyB-5j62A:undetectable | 5csyB-5j62A:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldn | HEXON PROTEIN,HEXONCAPSID (HumanmastadenovirusC) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 4 | PHE A 944HIS A 898LEU A 900PRO A 943 | None | 1.34A | 5csyB-5ldnA:undetectable | 5csyB-5ldnA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0j | ADP-DEPENDENTGLUCOKINASE (Pyrococcushorikoshii) |
no annotation | 4 | PHE A 147HIS A 135LEU A 30PRO A 167 | None | 1.34A | 5csyB-5o0jA:undetectable | 5csyB-5o0jA:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5olj | DIPEPTIDYL PEPTIDASEIV (Porphyromonasgingivalis) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 4 | PHE A 498HIS A 503LEU A 579PRO A 495 | None | 1.45A | 5csyB-5oljA:undetectable | 5csyB-5oljA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vh6 | ELONGATION FACTOR G (Bacillussubtilis) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2) | 4 | TYR A 186PHE A 144LEU A 257PRO A 165 | CL A 501 (-4.7A)NoneNoneNone | 1.28A | 5csyB-5vh6A:undetectable | 5csyB-5vh6A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vkt | CINNAMYL ALCOHOLDEHYDROGENASES(SBCAD4) (Sorghum bicolor) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | TYR A 63PHE A 137LEU A 51PRO A 67 | None | 1.49A | 5csyB-5vktA:undetectable | 5csyB-5vktA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | 40S RIBOSOMALPROTEIN S5-B,PUTATIVE (Trichomonasvaginalis) |
PF00177(Ribosomal_S7) | 4 | PHE F 86HIS F 35LEU F 57PRO F 97 | None | 1.42A | 5csyB-5xyiF:undetectable | 5csyB-5xyiF:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y00 | GREEN FLUORESCENTPROTEIN (Olindias) |
no annotation | 4 | TYR A 238HIS A 157LEU A 164PRO A 197 | GOL A 302 ( 4.4A)NoneNoneNone | 1.39A | 5csyB-5y00A:undetectable | 5csyB-5y00A:9.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y31 | DISINTEGRIN ANDMETALLOPROTEINASEDOMAIN-CONTAININGPROTEIN 22 (Homo sapiens) |
no annotation | 4 | TYR A 344PHE A 335HIS A 328LEU A 329 | None | 1.27A | 5csyB-5y31A:undetectable | 5csyB-5y31A:8.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk7 | ELONGATION FACTOR G (Enterococcusfaecalis) |
no annotation | 4 | TYR A 186PHE A 144LEU A 257PRO A 165 | None | 1.38A | 5csyB-6bk7A:undetectable | 5csyB-6bk7A:8.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byw | GOXA (Pseudoalteromonasluteoviolacea) |
no annotation | 4 | TYR B 154PHE B 619LEU B 616PRO B 11 | None | 0.80A | 5csyB-6bywB:undetectable | 5csyB-6bywB:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eon | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
no annotation | 4 | PHE A 512HIS A 385LEU A 383PRO A 507 | None | 1.35A | 5csyB-6eonA:10.3 | 5csyB-6eonA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f5d | ATP SYNTHASE SUBUNITBETA (Trypanosomabrucei) |
no annotation | 4 | TYR D 247PHE D 101LEU D 97PRO D 91 | None | 1.47A | 5csyB-6f5dD:undetectable | 5csyB-6f5dD:9.59 |