SIMILAR PATTERNS OF AMINO ACIDS FOR 5CSW_B_P06B801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajk CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		3 PHE A  66
ILE A  25
ASP A  78
 None
 0.70A 5cswB-1ajkA:
0.0		 5cswB-1ajkA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		3 PHE A  23
ILE A 196
ASP A  35
 None
 0.70A 5cswB-1ajoA:
0.0		 5cswB-1ajoA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ako EXONUCLEASE III

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		3 PHE A 199
ILE A 246
ASP A 151
 None
 0.73A 5cswB-1akoA:
undetectable		 5cswB-1akoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		3 PHE A  91
ILE A  50
ASP A 103
 None
 0.64A 5cswB-1axkA:
0.0		 5cswB-1axkA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		3 PHE S 717
ILE S 644
ASP S 703
 None
 0.43A 5cswB-1bkdS:
0.0		 5cswB-1bkdS:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpn CIRCULARLY PERMUTED

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		3 PHE A  91
ILE A  50
ASP A 103
 None
 0.69A 5cswB-1cpnA:
0.0		 5cswB-1cpnA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cr5 SEC18P (RESIDUES 22
- 210)

(Saccharomyces
cerevisiae) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		3 PHE A  66
ILE A  60
ASP A  51
 None
 0.73A 5cswB-1cr5A:
0.0		 5cswB-1cr5A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5c RAB6 GTPASE

(Plasmodium
falciparum) 		PF00071
(Ras) 		3 PHE A  16
ILE A  27
ASP A  92
 None
 0.53A 5cswB-1d5cA:
0.0		 5cswB-1d5cA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		3 PHE A 452
ILE A 454
ASP A 420
 None
 0.49A 5cswB-1f3lA:
0.0		 5cswB-1f3lA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		3 PHE A 241
ILE A 237
ASP A 248
 None
 0.68A 5cswB-1fehA:
undetectable		 5cswB-1fehA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6o CAG-ALPHA

(Helicobacter
pylori) 		PF00437
(T2SSE) 		3 PHE A  84
ILE A 116
ASP A  97
 None
 0.70A 5cswB-1g6oA:
undetectable		 5cswB-1g6oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6q HNRNP ARGININE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF06325
(PrmA) 		3 PHE 1 258
ILE 1 260
ASP 1 226
 None
 0.44A 5cswB-1g6q1:
undetectable		 5cswB-1g6q1:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00722
(Glyco_hydro_16) 		3 PHE A 149
ILE A 108
ASP A 161
 None
 0.69A 5cswB-1gbgA:
undetectable		 5cswB-1gbgA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 PHE A 147
ILE A 251
ASP A 398
 None
 0.76A 5cswB-1gwiA:
undetectable		 5cswB-1gwiA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		3 PHE A 216
ILE A 218
ASP A 144
 None
None
CD  A 402 (-2.3A)
 0.54A 5cswB-1gynA:
undetectable		 5cswB-1gynA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 PHE D 702
ILE D 704
ASP D 671
 None
 0.47A 5cswB-1hqrD:
undetectable		 5cswB-1hqrD:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		3 PHE P  68
ILE P  73
ASP P 244
 None
 0.69A 5cswB-1jcmP:
undetectable		 5cswB-1jcmP:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 PHE A 144
ILE A 250
ASP A 396
 None
 0.73A 5cswB-1jioA:
undetectable		 5cswB-1jioA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		3 PHE A 285
ILE A 266
ASP A 277
 None
 0.75A 5cswB-1kijA:
undetectable		 5cswB-1kijA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1s HYPOTHETICAL PROTEIN
MTH1491

(Methanothermobacter
thermautotrophicus) 		PF02635
(DrsE) 		3 PHE A   8
ILE A  37
ASP A  91
 None
 0.73A 5cswB-1l1sA:
undetectable		 5cswB-1l1sA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 PHE A 303
ILE A 296
ASP A 331
 None
 0.73A 5cswB-1ldjA:
1.4		 5cswB-1ldjA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF00215
(OMPdecase) 		3 PHE A 100
ILE A 135
ASP A 140
 None
 0.66A 5cswB-1losA:
undetectable		 5cswB-1losA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m68 HYPOTHETICAL PROTEIN
YCDX

(Escherichia
coli) 		PF02811
(PHP) 		3 PHE A  35
ILE A  37
ASP A 192
 None
None
ZN  A 302 (-2.6A)
 0.68A 5cswB-1m68A:
undetectable		 5cswB-1m68A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		3 PHE A 147
ILE A 106
ASP A 159
 None
 0.66A 5cswB-1macA:
undetectable		 5cswB-1macA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n27 HEPATOMA-DERIVED
GROWTH FACTOR,
RELATED PROTEIN 3

(Mus musculus) 		PF00855
(PWWP) 		3 PHE A  16
ILE A  88
ASP A  30
 None
 0.72A 5cswB-1n27A:
undetectable		 5cswB-1n27A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		3 PHE B 284
ILE B  55
ASP B 297
 None
None
ZN  B   2 (-2.3A)
 0.58A 5cswB-1n94B:
undetectable		 5cswB-1n94B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1noz DNA POLYMERASE

(Escherichia
virus T4) 		PF03104
(DNA_pol_B_exo1) 		3 PHE A 352
ILE A 209
ASP A 269
 None
 0.71A 5cswB-1nozA:
undetectable		 5cswB-1nozA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5l TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY

(Thermotoga
maritima) 		PF00027
(cNMP_binding) 		3 PHE A 108
ILE A  61
ASP A   2
 None
 0.65A 5cswB-1o5lA:
undetectable		 5cswB-1o5lA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		3 PHE A 164
ILE A 123
ASP A 154
 None
 0.65A 5cswB-1oltA:
undetectable		 5cswB-1oltA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1

(Rattus
norvegicus) 		PF13649
(Methyltransf_25) 		3 PHE A 270
ILE A 272
ASP A 238
 None
 0.46A 5cswB-1or8A:
undetectable		 5cswB-1or8A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7n GAG POLYPROTEIN
CAPSID PROTEIN P27

(Rous sarcoma
virus) 		no annotation 3 PHE A 140
ILE A  60
ASP A  52
 None
 0.65A 5cswB-1p7nA:
undetectable		 5cswB-1p7nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		3 PHE A  68
ILE A  73
ASP A 244
 None
 0.57A 5cswB-1piiA:
undetectable		 5cswB-1piiA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE

(Trichoderma
reesei) 		PF01083
(Cutinase) 		3 PHE A  96
ILE A  95
ASP A 153
 None
 0.73A 5cswB-1qozA:
undetectable		 5cswB-1qozA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r18 PROTEIN-L-ISOASPARTA
TE(D-ASPARTATE)-O-ME
THYLTRANSFERASE

(Drosophila
melanogaster) 		PF01135
(PCMT) 		3 PHE A  96
ILE A  82
ASP A 106
 None
 0.70A 5cswB-1r18A:
undetectable		 5cswB-1r18A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 PHE A 339
ILE A 311
ASP A 101
 None
 0.75A 5cswB-1r6uA:
undetectable		 5cswB-1r6uA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa3 TYPE II RESTRICTION
ENZYME MSPI

(Moraxella sp.) 		PF09208
(Endonuc-MspI) 		3 PHE A  42
ILE A  38
ASP A  84
 None
None
NA  A 401 (-3.2A)
 0.68A 5cswB-1sa3A:
undetectable		 5cswB-1sa3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		3 PHE A 169
ILE A 139
ASP A 165
 None
 0.73A 5cswB-1t0bA:
undetectable		 5cswB-1t0bA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		3 PHE A 481
ILE A 475
ASP A  43
 None
 0.72A 5cswB-1uqwA:
undetectable		 5cswB-1uqwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 PHE A 717
ILE A 644
ASP A 703
 None
 0.43A 5cswB-1xdvA:
undetectable		 5cswB-1xdvA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		3 PHE A 308
ILE A 276
ASP A 151
 None
 0.72A 5cswB-1xe4A:
undetectable		 5cswB-1xe4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		3 PHE A 614
ILE A 595
ASP A 590
 None
 0.74A 5cswB-1xfuA:
undetectable		 5cswB-1xfuA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		3 PHE A 147
ILE A 185
ASP A 130
 None
 0.62A 5cswB-1yaaA:
undetectable		 5cswB-1yaaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqb UBIQUILIN 3

(Homo sapiens) 		PF00240
(ubiquitin) 		3 PHE A  54
ILE A  50
ASP A  59
 None
 0.75A 5cswB-1yqbA:
undetectable		 5cswB-1yqbA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 PHE A 537
ILE A 548
ASP A 541
 None
 0.73A 5cswB-1z1wA:
undetectable		 5cswB-1z1wA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		3 PHE A 490
ILE A 486
ASP A 483
 None
 0.67A 5cswB-2a3lA:
undetectable		 5cswB-2a3lA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a79 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY A
MEMBER 2

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF02214
(BTB_2) 		3 PHE B  78
ILE B  37
ASP B  86
 None
 0.75A 5cswB-2a79B:
undetectable		 5cswB-2a79B:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae8 IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Staphylococcus
aureus) 		PF00475
(IGPD) 		3 PHE A 135
ILE A  68
ASP A  60
 None
 0.55A 5cswB-2ae8A:
undetectable		 5cswB-2ae8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		3 PHE B2181
ILE B2201
ASP B2187
 None
 0.54A 5cswB-2assB:
undetectable		 5cswB-2assB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7y FAVIN BETA CHAIN

(Vicia faba) 		PF00139
(Lectin_legB) 		3 PHE A  64
ILE A  53
ASP A   2
 None
 0.76A 5cswB-2b7yA:
undetectable		 5cswB-2b7yA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		3 PHE A 286
ILE A 273
ASP A 315
 None
 0.55A 5cswB-2c4mA:
undetectable		 5cswB-2c4mA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccm CALEXCITIN

(Doryteuthis
pealeii) 		no annotation 3 PHE A  35
ILE A  65
ASP A 116
 None
 0.76A 5cswB-2ccmA:
undetectable		 5cswB-2ccmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		3 PHE A  22
ILE A  18
ASP A  33
 None
None
NAD  A1251 (-2.7A)
 0.75A 5cswB-2cfcA:
undetectable		 5cswB-2cfcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 PHE A  29
ILE A  45
ASP A 173
 None
 0.64A 5cswB-2cfmA:
undetectable		 5cswB-2cfmA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
CO-CHAPERONE PROTEIN
SBA1

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c)
no annotation 		3 PHE X 121
ILE A 388
ASP X 128
 None
 0.75A 5cswB-2cg9X:
undetectable		 5cswB-2cg9X:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cme HYPOTHETICAL PROTEIN
5

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF09399
(SARS_lipid_bind) 		3 PHE C  92
ILE C  46
ASP C  17
 None
 0.73A 5cswB-2cmeC:
undetectable		 5cswB-2cmeC:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Pyrococcus
horikoshii) 		PF00215
(OMPdecase) 		3 PHE A  87
ILE A 117
ASP A 122
 None
 0.70A 5cswB-2czdA:
undetectable		 5cswB-2czdA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		3 PHE A 199
ILE A 305
ASP A 109
 None
 0.75A 5cswB-2d7sA:
undetectable		 5cswB-2d7sA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		3 PHE A 351
ILE A 134
ASP A 330
 None
 0.72A 5cswB-2eaaA:
undetectable		 5cswB-2eaaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 PHE A  41
ILE A 183
ASP A  11
 None
None
MN  A 501 (-2.5A)
 0.59A 5cswB-2eb0A:
1.2		 5cswB-2eb0A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 PHE A  41
ILE A 183
ASP A  13
 None
None
MN  A 502 (-3.2A)
 0.65A 5cswB-2eb0A:
1.2		 5cswB-2eb0A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebn ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F1

(Elizabethkingia
meningoseptica) 		PF00704
(Glyco_hydro_18) 		3 PHE A 128
ILE A 196
ASP A  40
 None
 0.67A 5cswB-2ebnA:
undetectable		 5cswB-2ebnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eia EIAV CAPSID PROTEIN
P26

(Equine
infectious
anemia virus) 		PF00607
(Gag_p24) 		3 PHE A 106
ILE A 100
ASP A 123
 None
 0.64A 5cswB-2eiaA:
undetectable		 5cswB-2eiaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		3 PHE X 119
ILE X 108
ASP X 158
 None
 0.54A 5cswB-2epkX:
undetectable		 5cswB-2epkX:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651

(Methanocaldococcus
jannaschii) 		PF01887
(SAM_adeno_trans) 		3 PHE A  74
ILE A  14
ASP A   9
 None
 0.66A 5cswB-2f4nA:
undetectable		 5cswB-2f4nA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv5 ADAM 17

(Homo sapiens) 		PF13688
(Reprolysin_5) 		3 PHE A 470
ILE A 462
ASP A 217
 None
 0.65A 5cswB-2fv5A:
undetectable		 5cswB-2fv5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 PHE A 548
ILE A 535
ASP A 469
 None
 0.69A 5cswB-2gepA:
2.6		 5cswB-2gepA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggj N-ACYLAMINO ACID
RACEMASE

(Deinococcus
radiodurans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PHE A  87
ILE A  10
ASP A 116
 None
 0.72A 5cswB-2ggjA:
undetectable		 5cswB-2ggjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gie TYPE II RESTRICTION
ENZYME HINCII

(Haemophilus
influenzae) 		PF09226
(Endonuc-HincII) 		3 PHE A 164
ILE A 166
ASP A 114
 None
 0.66A 5cswB-2gieA:
undetectable		 5cswB-2gieA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5k UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01704
(UDPGP) 		3 PHE A 134
ILE A 126
ASP A 166
 None
 0.73A 5cswB-2i5kA:
undetectable		 5cswB-2i5kA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		3 PHE A  66
ILE A  68
ASP A 108
 None
 0.76A 5cswB-2ichA:
undetectable		 5cswB-2ichA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Arabidopsis
thaliana) 		PF01704
(UDPGP) 		3 PHE A 110
ILE A 102
ASP A 142
 None
 0.67A 5cswB-2icyA:
undetectable		 5cswB-2icyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihd REGULATOR OF
G-PROTEIN SIGNALING
8

(Homo sapiens) 		PF00615
(RGS) 		3 PHE A 112
ILE A 108
ASP A 144
 None
 0.74A 5cswB-2ihdA:
2.9		 5cswB-2ihdA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 PHE A 633
ILE A 694
ASP A 164
 None
 0.73A 5cswB-2ivfA:
undetectable		 5cswB-2ivfA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdz MYB24

(Trichomonas
vaginalis) 		PF13921
(Myb_DNA-bind_6) 		3 PHE A  81
ILE A  78
ASP A  61
 None
 0.69A 5cswB-2kdzA:
undetectable		 5cswB-2kdzA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltl NIFU-LIKE PROTEIN,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF08712
(Nfu_N) 		3 PHE A  32
ILE A 102
ASP A  36
 None
 0.42A 5cswB-2ltlA:
undetectable		 5cswB-2ltlA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9x MICROTUBULE-ASSOCIAT
ED
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF08926
(DUF1908) 		3 PHE A  95
ILE A  49
ASP A  83
 None
 0.76A 5cswB-2m9xA:
undetectable		 5cswB-2m9xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpu RBP1

(Hordeum vulgare) 		PF00076
(RRM_1) 		3 PHE A  52
ILE A  41
ASP A  37
 None
 0.69A 5cswB-2mpuA:
undetectable		 5cswB-2mpuA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nm1 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 PHE A 899
ILE A 909
ASP A 889
 None
 0.68A 5cswB-2nm1A:
undetectable		 5cswB-2nm1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 PHE A 898
ILE A 908
ASP A 888
 None
 0.76A 5cswB-2np0A:
2.1		 5cswB-2np0A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odh R.BCNI

(Brevibacillus
centrosporus) 		PF15515
(MvaI_BcnI) 		3 PHE A  93
ILE A  89
ASP A 200
 None
 0.72A 5cswB-2odhA:
undetectable		 5cswB-2odhA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooi SA0254 PROTEIN

(Staphylococcus
aureus) 		PF07702
(UTRA) 		3 PHE A 221
ILE A  75
ASP A 131
 None
 0.72A 5cswB-2ooiA:
undetectable		 5cswB-2ooiA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2s PUTATIVE
OXIDOREDUCTASE

(Pectobacterium
atrosepticum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 PHE A 119
ILE A 317
ASP A 303
 None
 0.76A 5cswB-2p2sA:
undetectable		 5cswB-2p2sA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4p HYPOTHETICAL PROTEIN
HD1797

([Haemophilus]
ducreyi) 		PF03471
(CorC_HlyC) 		3 PHE A  62
ILE A  37
ASP A  73
 MLY  A  61 ( 4.5A)
None
None
 0.69A 5cswB-2p4pA:
undetectable		 5cswB-2p4pA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfe ALKALINE SERINE
PROTEASE

(Thermobifida
fusca) 		PF00089
(Trypsin) 		3 PHE A 227
ILE A 225
ASP A 219
 GOL  A 403 ( 4.8A)
None
None
 0.74A 5cswB-2pfeA:
2.2		 5cswB-2pfeA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcq BONE MORPHOGENETIC
PROTEIN 3

(Homo sapiens) 		PF00019
(TGF_beta) 		3 PHE A  17
ILE A  85
ASP A  89
 None
 0.72A 5cswB-2qcqA:
undetectable		 5cswB-2qcqA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		3 PHE A   5
ILE A  37
ASP A  46
 None
 0.76A 5cswB-2qt3A:
undetectable		 5cswB-2qt3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		3 PHE A 231
ILE A 155
ASP A 227
 None
NDP  A1523 (-4.5A)
None
 0.76A 5cswB-2vroA:
undetectable		 5cswB-2vroA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		3 PHE A 309
ILE A 361
ASP A 319
 None
 0.73A 5cswB-2wn4A:
undetectable		 5cswB-2wn4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		3 PHE A  87
ILE A  51
ASP A  38
 None
 0.72A 5cswB-2xxlA:
undetectable		 5cswB-2xxlA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 PHE A 765
ILE A 673
ASP A 666
 None
 0.76A 5cswB-2xyuA:
27.9		 5cswB-2xyuA:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y23 MYOMESIN

(Homo sapiens) 		PF07679
(I-set) 		3 PHE A1318
ILE A1301
ASP A1322
 None
 0.70A 5cswB-2y23A:
1.7		 5cswB-2y23A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 PHE A  74
ILE A  49
ASP A  95
 None
 0.66A 5cswB-2y3aA:
2.9		 5cswB-2y3aA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynp COATOMER SUBUNIT
BETA'

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		3 PHE A 455
ILE A 467
ASP A 523
 None
 0.74A 5cswB-2ynpA:
undetectable		 5cswB-2ynpA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvq CARBAMOYL-PHOSPHATE
SYNTHASE

(Homo sapiens) 		PF02142
(MGS) 		3 PHE A1374
ILE A1364
ASP A1396
 None
 0.70A 5cswB-2yvqA:
undetectable		 5cswB-2yvqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zet RAS-RELATED PROTEIN
RAB-27B

(Mus musculus) 		PF00071
(Ras) 		3 PHE A  25
ILE A 131
ASP A  17
 None
 0.75A 5cswB-2zetA:
undetectable		 5cswB-2zetA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus) 		no annotation 3 PHE A 695
ILE A 632
ASP A 688
 None
 0.68A 5cswB-3afbA:
0.6		 5cswB-3afbA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7x FK506-BINDING
PROTEIN 6

(Homo sapiens) 		PF00254
(FKBP_C) 		3 PHE A 110
ILE A 137
ASP A  73
 None
 0.51A 5cswB-3b7xA:
undetectable		 5cswB-3b7xA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt3 GLYOXALASE-RELATED
ENZYME, ARAC TYPE

(Lachnoclostridium
phytofermentans) 		no annotation 3 PHE A 260
ILE A 250
ASP A 237
 None
 0.65A 5cswB-3bt3A:
undetectable		 5cswB-3bt3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		3 PHE A 321
ILE A 415
ASP A 326
 None
 0.73A 5cswB-3cb5A:
undetectable		 5cswB-3cb5A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 PHE A 582
ILE A 577
ASP A 628
 None
 0.72A 5cswB-3ciyA:
undetectable		 5cswB-3ciyA:
16.47