SIMILAR PATTERNS OF AMINO ACIDS FOR 5CSW_B_P06B801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  41
ALA A  54
LYS A  56
LEU A  78
PHE A 172
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
ANP  A 400 (-2.9A)
None
None
 0.79A 5cswB-1cm8A:
20.9		 5cswB-1cm8A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  18
ALA A  31
LYS A  33
CYH A  83
PHE A 145
 None
 0.76A 5cswB-1h4lA:
23.1		 5cswB-1h4lA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 VAL A 172
ALA A 185
LYS A 187
LEU A 206
LEU A 226
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.4A)
 0.78A 5cswB-1q8yA:
20.7		 5cswB-1q8yA:
24.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 603
ALA A 621
LYS A 623
LEU A 644
THR A 670
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
 0.77A 5cswB-1t46A:
26.7		 5cswB-1t46A:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 603
ALA A 621
LYS A 623
THR A 670
CYH A 673
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
 0.34A 5cswB-1t46A:
26.7		 5cswB-1t46A:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
LYS A  57
LEU A  80
CYH A 108
GLY A 168
 None
 0.83A 5cswB-1u5qA:
24.0		 5cswB-1u5qA:
30.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
LYS A  57
LEU A  80
GLY A 168
PHE A 170
 None
 0.94A 5cswB-1u5qA:
24.0		 5cswB-1u5qA:
30.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  23
ALA A  36
LYS A  38
CYH A  87
PHE A 149
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
 0.64A 5cswB-1zltA:
12.0		 5cswB-1zltA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
LYS A  42
LEU A  68
PHE A 162
 None
 0.85A 5cswB-1zwsA:
24.0		 5cswB-1zwsA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 VAL A 613
ALA A 626
LEU A 647
CYH A 791
PHE A 842
GLY A 852
PHE A 854
 None
GOL  A 998 ( 3.7A)
None
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
None
None
 0.96A 5cswB-1zy4A:
22.0		 5cswB-1zy4A:
29.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B 281
LYS B 296
CYH B 369
PHE B 421
GLY B 431
PHE B 433
 None
 0.82A 5cswB-2a1aB:
21.8		 5cswB-2a1aB:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
LYS A  42
LEU A  68
PHE A 162
 None
GOL  A3001 (-3.5A)
None
None
None
 0.75A 5cswB-2a2aA:
24.2		 5cswB-2a2aA:
26.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL X  25
ALA X  37
LYS X  39
THR X  82
PHE X 149
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
None
 0.72A 5cswB-2dq7X:
27.2		 5cswB-2dq7X:
32.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 170
ALA A 184
LYS A 186
LEU A 205
PHE A 321
 None
 0.80A 5cswB-2eu9A:
21.2		 5cswB-2eu9A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
LYS A  42
LEU A  63
PHE A 156
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
 0.83A 5cswB-2f9gA:
21.5		 5cswB-2f9gA:
26.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
LEU A  80
CYH A 108
GLY A 168
PHE A 170
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
None
STU  A 400 (-4.0A)
None
None
 0.66A 5cswB-2gcdA:
25.3		 5cswB-2gcdA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
ALA A 271
LYS A 273
THR A 316
PHE A 383
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
 0.87A 5cswB-2hk5A:
26.5		 5cswB-2hk5A:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  34
ALA A  47
LYS A  49
PHE A 159
GLY A 170
PHE A 172
 None
 0.81A 5cswB-2i6lA:
22.7		 5cswB-2i6lA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 563
PHE A 565
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
None
 0.82A 5cswB-2j0jA:
28.5		 5cswB-2j0jA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 563
PHE A 565
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
BII  A1687 (-4.1A)
BII  A1687 ( 3.9A)
None
 0.89A 5cswB-2jkmA:
28.0		 5cswB-2jkmA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 596
ALA A 614
LYS A 616
THR A 663
CYH A 666
GLY A 795
 None
 0.48A 5cswB-2ogvA:
24.9		 5cswB-2ogvA:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 VAL A  33
ALA A  46
LYS A  48
LEU A  77
PHE A 168
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
 0.86A 5cswB-2phkA:
23.3		 5cswB-2phkA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.88A 5cswB-2qluA:
25.0		 5cswB-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A 449
LYS A 451
LEU A 467
THR A 493
PHE A 562
 None
 0.81A 5cswB-2qr7A:
20.0		 5cswB-2qr7A:
25.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 VAL A 689
ALA A 705
LYS A 707
THR A 753
PHE A 819
 None
 0.86A 5cswB-2r2pA:
27.2		 5cswB-2r2pA:
32.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq6 ATP SYNTHASE EPSILON
CHAIN

(Thermosynechococcus
elongatus) 		PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N) 		5 VAL A  74
ALA A  67
LEU A  31
THR A  42
GLY A  32
 None
 0.86A 5cswB-2rq6A:
undetectable		 5cswB-2rq6A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq7 ATP SYNTHASE EPSILON
CHAIN

(Spinacia
oleracea;
Thermosynechococcus
elongatus) 		PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N) 		5 VAL A  74
ALA A  67
LEU A  31
THR A  42
GLY A  32
 None
 0.80A 5cswB-2rq7A:
undetectable		 5cswB-2rq7A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
LYS A  42
LEU A  68
PHE A 162
 AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
 0.86A 5cswB-2yabA:
24.1		 5cswB-2yabA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 313
ALA A 326
CYH A 379
PHE A 433
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
 0.57A 5cswB-2z2wA:
22.7		 5cswB-2z2wA:
27.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A1010
ALA A1028
LYS A1030
GLY A1149
PHE A1151
 S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
None
 0.68A 5cswB-2z8cA:
26.5		 5cswB-2z8cA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 261
ALA A 273
LYS A 275
THR A 319
PHE A 386
 None
 0.85A 5cswB-2zv7A:
27.1		 5cswB-2zv7A:
34.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
ALA A  40
LYS A  42
LEU A  68
PHE A 162
 4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
None
None
 0.75A 5cswB-3bqrA:
22.4		 5cswB-3bqrA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  52
ALA A  65
LYS A  67
LEU A  93
PHE A 187
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
None
 0.73A 5cswB-3f2aA:
18.1		 5cswB-3f2aA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 VAL A 649
ALA A 665
LYS A 667
THR A 713
PHE A 779
 None
 0.86A 5cswB-3kulA:
28.2		 5cswB-3kulA:
33.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 VAL A  76
ALA A  89
LYS A  91
LEU A 113
PHE A 206
 ANP  A 522 (-4.1A)
ANP  A 522 (-3.6A)
ANP  A 522 (-3.5A)
None
None
 0.54A 5cswB-3lijA:
25.4		 5cswB-3lijA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 VAL A 689
ALA A 700
LYS A 702
CYH A 748
PHE A 829
 ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
ADP  A2101 (-4.2A)
None
 0.72A 5cswB-3lj0A:
23.4		 5cswB-3lj0A:
23.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
 0.72A 5cswB-3mdyA:
25.1		 5cswB-3mdyA:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  33
ALA A  46
LYS A  48
LEU A  70
PHE A 168
 None
 0.81A 5cswB-3mi9A:
17.6		 5cswB-3mi9A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 PHE A 231
VAL A 216
ALA A 227
LEU A 257
THR A 277
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
 0.86A 5cswB-3my0A:
24.2		 5cswB-3my0A:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
 0.54A 5cswB-3my0A:
24.2		 5cswB-3my0A:
28.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 373
LYS A 375
LEU A 397
THR A 421
TRP A 423
PHE A 475
GLY A 485
PHE A 487
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
None
 0.95A 5cswB-3omvA:
34.5		 5cswB-3omvA:
75.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 363
ALA A 373
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
PHE A 475
GLY A 485
PHE A 487
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
 0.85A 5cswB-3omvA:
34.5		 5cswB-3omvA:
75.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
 0.64A 5cswB-3q4tA:
24.8		 5cswB-3q4tA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  71
ALA A  84
LYS A  86
LEU A 119
THR A 144
PHE A 212
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
 0.71A 5cswB-3q5iA:
21.6		 5cswB-3q5iA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		6 VAL A 248
ALA A 261
LYS A 263
LEU A 304
PHE A 396
GLY A 406
 ATP  A 600 (-4.3A)
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
 0.89A 5cswB-3q60A:
18.2		 5cswB-3q60A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
PHE B 954
 None
 0.84A 5cswB-3qd2B:
22.4		 5cswB-3qd2B:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1959
ALA A1978
LYS A1980
LEU A2010
GLY A2101
PHE A2103
 None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
None
 0.92A 5cswB-3zbfA:
22.4		 5cswB-3zbfA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 633
ALA A 649
LYS A 651
THR A 697
PHE A 763
 None
 0.74A 5cswB-3zfxA:
27.9		 5cswB-3zfxA:
33.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 0.71A 5cswB-4a4lA:
18.2		 5cswB-4a4lA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  18
ALA A  31
LYS A  33
CYH A  83
PHE A 145
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
D15  A 500 (-4.3A)
None
 0.65A 5cswB-4aguA:
23.7		 5cswB-4aguA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  18
ALA A  31
LYS A  33
LEU A  55
PHE A 145
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
None
 0.85A 5cswB-4aguA:
23.7		 5cswB-4aguA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
PHE A 204
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
 0.79A 5cswB-4b6lA:
24.0		 5cswB-4b6lA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 PHE A 237
VAL A 222
ALA A 233
LEU A 263
THR A 283
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.84A 5cswB-4c02A:
24.3		 5cswB-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
 0.51A 5cswB-4c02A:
24.3		 5cswB-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
LYS A  38
LEU A  59
CYH A  89
PHE A 158
 BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
None
 0.80A 5cswB-4eutA:
13.9		 5cswB-4eutA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
LYS A  38
LEU A  59
CYH A  89
PHE A 158
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
None
 0.84A 5cswB-4euuA:
17.4		 5cswB-4euuA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A1130
ALA A1148
LYS A1150
GLY A1269
PHE A1271
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-4.5A)
None
 0.73A 5cswB-4fodA:
21.9		 5cswB-4fodA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 606
ALA A 619
CYH A 890
PHE A 943
GLY A 953
PHE A 955
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
 0.74A 5cswB-4g34A:
23.3		 5cswB-4g34A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 606
ALA A 619
LYS A 621
CYH A 890
GLY A 953
PHE A 955
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
 0.92A 5cswB-4g34A:
23.3		 5cswB-4g34A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 606
LEU A 642
CYH A 890
PHE A 943
PHE A 955
 924  A1101 ( 4.8A)
924  A1101 (-3.9A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 ( 4.4A)
 0.88A 5cswB-4g34A:
23.3		 5cswB-4g34A:
28.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 863
ALA A 880
LYS A 882
GLY A 993
PHE A 995
 None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
 0.82A 5cswB-4gl9A:
25.5		 5cswB-4gl9A:
31.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
 None
 0.66A 5cswB-4hzsA:
27.3		 5cswB-4hzsA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
LYS A 111
CYH A 162
PHE A 212
GLY A 222
PHE A 224
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
1C7  A 401 (-4.0A)
None
None
 0.79A 5cswB-4i6fA:
22.6		 5cswB-4i6fA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
1G0  A 401 ( 4.8A)
 0.88A 5cswB-4id7A:
26.9		 5cswB-4id7A:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		6 ALA A  66
LYS A  68
CYH A 119
PHE A 169
GLY A 179
PHE A 181
 None
 0.72A 5cswB-4j7bA:
24.1		 5cswB-4j7bA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
 1.11A 5cswB-4m69A:
26.9		 5cswB-4m69A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 VAL A  86
ALA A  99
LYS A 101
CYH A 149
PHE A 214
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
STU  A 601 (-4.2A)
None
 0.84A 5cswB-4mvfA:
21.2		 5cswB-4mvfA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  54
ALA A  67
LYS A  69
THR A 123
CYH A 126
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.62A 5cswB-4o38A:
20.9		 5cswB-4o38A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 VAL A 394
ALA A 407
LYS A 409
LEU A 432
PHE A 523
 PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
 0.83A 5cswB-4q9zA:
20.7		 5cswB-4q9zA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 VAL A 353
ALA A 366
LYS A 368
LEU A 391
PHE A 482
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 ( 4.7A)
None
None
 0.86A 5cswB-4ra4A:
21.2		 5cswB-4ra4A:
27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 477
ALA A 488
LYS A 490
LEU A 513
THR A 539
PHE A 607
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
None
 0.88A 5cswB-4yffA:
26.7		 5cswB-4yffA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 173
ALA A 186
LYS A 188
LEU A 207
PHE A 308
 4E1  A 505 (-4.5A)
4E1  A 505 (-3.5A)
4E1  A 505 (-2.7A)
None
None
 0.70A 5cswB-4yljA:
20.6		 5cswB-4yljA:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  42
ALA A  55
LYS A  57
LEU A  80
THR A 105
PHE A 173
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
 0.85A 5cswB-4ysjA:
25.0		 5cswB-4ysjA:
22.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  30
ALA A  44
LYS A  46
CYH A  95
PHE A 166
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
51W  A 401 (-3.9A)
None
 0.69A 5cswB-5ci7A:
22.8		 5cswB-5ci7A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  30
ALA A  44
LYS A  46
LEU A  67
PHE A 166
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
None
 0.86A 5cswB-5ci7A:
22.8		 5cswB-5ci7A:
31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 258
ALA A 275
LYS A 277
LEU A 305
THR A 325
PHE A 398
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
 0.58A 5cswB-5e8yA:
24.5		 5cswB-5e8yA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		5 VAL A 548
ALA A 561
LYS A 563
THR A 611
PHE A 676
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.9A)
 0.78A 5cswB-5ezrA:
19.5		 5cswB-5ezrA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 911
ALA A 928
LYS A 930
GLY A1040
PHE A1042
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.9A)
None
 0.81A 5cswB-5f1zA:
26.1		 5cswB-5f1zA:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 PHE A 468
ALA A 481
LYS A 483
LEU A 514
THR A 529
CYH A 532
GLY A 593
 None
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.6A)
5XJ  A 801 ( 3.7A)
 1.50A 5cswB-5fd2A:
36.2		 5cswB-5fd2A:
93.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 VAL A 471
ALA A 481
LYS A 483
LEU A 505
LEU A 514
THR A 529
TRP A 531
CYH A 532
PHE A 583
GLY A 593
PHE A 595
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
5XJ  A 801 (-3.7A)
 0.72A 5cswB-5fd2A:
36.2		 5cswB-5fd2A:
93.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 607
ALA A 625
LYS A 627
THR A 674
CYH A 677
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
 0.42A 5cswB-5grnA:
26.5		 5cswB-5grnA:
28.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A  30
ALA A  43
LYS A  45
LEU A  57
THR A  82
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-3.7A)
 0.67A 5cswB-5hesA:
26.3		 5cswB-5hesA:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  30
ALA A  43
LYS A  45
CYH A  93
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
None
 0.72A 5cswB-5j5tA:
22.1		 5cswB-5j5tA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 404
ALA A 417
LYS A 419
LEU A 440
GLY A 532
PHE A 534
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 ( 4.7A)
None
 0.81A 5cswB-5jznA:
23.4		 5cswB-5jznA:
27.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL B 680
ALA B 690
THR B 739
CYH B 742
PHE B 793
 6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
6U7  B1001 (-4.3A)
 0.77A 5cswB-5kkrB:
26.0		 5cswB-5kkrB:
36.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 228
LYS A 230
LEU A 263
CYH A 286
PHE A 350
 6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
6UY  A 501 (-4.3A)
None
 0.84A 5cswB-5ko1A:
25.2		 5cswB-5ko1A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		6 VAL A 161
ALA A 174
LEU A 198
THR A 227
PHE A 282
GLY A 293
 None
GOL  A 604 ( 3.8A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
GOL  A 604 ( 4.6A)
 0.72A 5cswB-5o2cA:
26.0		 5cswB-5o2cA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 5 VAL A  52
ALA A  65
LYS A  67
LEU A  93
PHE A 187
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
 0.78A 5cswB-5turA:
22.7		 5cswB-5turA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 5 VAL A  25
ALA A  38
LYS A  40
CYH A  89
PHE A 151
 7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-4.3A)
None
 0.82A 5cswB-5tvtA:
22.9		 5cswB-5tvtA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
 0.63A 5cswB-5vcxA:
22.4		 5cswB-5vcxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
PHE A 252
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
 0.83A 5cswB-5vcxA:
22.4		 5cswB-5vcxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 226
ALA A 239
CYH A 292
PHE A 346
GLY A 379
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
None
 0.55A 5cswB-5vdkA:
16.4		 5cswB-5vdkA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 VAL A  32
ALA A  45
LYS A  47
LEU A  79
THR A  95
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
 0.48A 5cswB-5w5jA:
26.8		 5cswB-5w5jA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 5 VAL A  37
ALA A  50
LYS A  52
LEU A  93
THR A 118
 ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
None
ADP  A 401 (-4.1A)
 0.86A 5cswB-5x1tA:
21.8		 5cswB-5x1tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 5 VAL A 741
ALA A 754
LYS A 756
LEU A 778
PHE A 878
 None
CJM  A1102 (-3.1A)
None
None
None
 0.62A 5cswB-6b3eA:
23.4		 5cswB-6b3eA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 VAL A 889
ALA A 906
LYS A 908
GLY A1020
PHE A1022
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
 0.67A 5cswB-6c7yA:
25.5		 5cswB-6c7yA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 6 PHE A 280
VAL A 283
ALA A 296
LYS A 298
GLY A 410
PHE A 412
 None
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.3A)
FE7  A 601 (-3.6A)
FE7  A 601 ( 4.1A)
None
 0.95A 5cswB-6cthA:
22.3		 5cswB-6cthA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 VAL A 205
ALA A 217
LEU A 248
THR A 264
GLY A 329
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.4A)
 0.72A 5cswB-6cz4A:
17.8		 5cswB-6cz4A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 5 VAL A 177
ALA A 191
LYS A 193
LEU A 212
PHE A 328
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
None
None
 0.84A 5cswB-6fylA:
21.4		 5cswB-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 VAL A 175
ALA A 189
LYS A 191
LEU A 210
PHE A 326
 3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
None
None
 0.77A 5cswB-6fyvA:
21.4		 5cswB-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajk CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		3 PHE A  66
ILE A  25
ASP A  78
 None
 0.70A 5cswB-1ajkA:
0.0		 5cswB-1ajkA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		3 PHE A  23
ILE A 196
ASP A  35
 None
 0.70A 5cswB-1ajoA:
0.0		 5cswB-1ajoA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ako EXONUCLEASE III

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		3 PHE A 199
ILE A 246
ASP A 151
 None
 0.73A 5cswB-1akoA:
undetectable		 5cswB-1akoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		3 PHE A  91
ILE A  50
ASP A 103
 None
 0.64A 5cswB-1axkA:
0.0		 5cswB-1axkA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		3 PHE S 717
ILE S 644
ASP S 703
 None
 0.43A 5cswB-1bkdS:
0.0		 5cswB-1bkdS:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpn CIRCULARLY PERMUTED

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		3 PHE A  91
ILE A  50
ASP A 103
 None
 0.69A 5cswB-1cpnA:
0.0		 5cswB-1cpnA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cr5 SEC18P (RESIDUES 22
- 210)

(Saccharomyces
cerevisiae) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		3 PHE A  66
ILE A  60
ASP A  51
 None
 0.73A 5cswB-1cr5A:
0.0		 5cswB-1cr5A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5c RAB6 GTPASE

(Plasmodium
falciparum) 		PF00071
(Ras) 		3 PHE A  16
ILE A  27
ASP A  92
 None
 0.53A 5cswB-1d5cA:
0.0		 5cswB-1d5cA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		3 PHE A 452
ILE A 454
ASP A 420
 None
 0.49A 5cswB-1f3lA:
0.0		 5cswB-1f3lA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		3 PHE A 241
ILE A 237
ASP A 248
 None
 0.68A 5cswB-1fehA:
undetectable		 5cswB-1fehA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6o CAG-ALPHA

(Helicobacter
pylori) 		PF00437
(T2SSE) 		3 PHE A  84
ILE A 116
ASP A  97
 None
 0.70A 5cswB-1g6oA:
undetectable		 5cswB-1g6oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6q HNRNP ARGININE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF06325
(PrmA) 		3 PHE 1 258
ILE 1 260
ASP 1 226
 None
 0.44A 5cswB-1g6q1:
undetectable		 5cswB-1g6q1:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gbg (1,3-1,4)-BETA-D-GLU
CAN 4
GLUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00722
(Glyco_hydro_16) 		3 PHE A 149
ILE A 108
ASP A 161
 None
 0.69A 5cswB-1gbgA:
undetectable		 5cswB-1gbgA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 PHE A 147
ILE A 251
ASP A 398
 None
 0.76A 5cswB-1gwiA:
undetectable		 5cswB-1gwiA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		3 PHE A 216
ILE A 218
ASP A 144
 None
None
CD  A 402 (-2.3A)
 0.54A 5cswB-1gynA:
undetectable		 5cswB-1gynA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 PHE D 702
ILE D 704
ASP D 671
 None
 0.47A 5cswB-1hqrD:
undetectable		 5cswB-1hqrD:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		3 PHE P  68
ILE P  73
ASP P 244
 None
 0.69A 5cswB-1jcmP:
undetectable		 5cswB-1jcmP:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 PHE A 144
ILE A 250
ASP A 396
 None
 0.73A 5cswB-1jioA:
undetectable		 5cswB-1jioA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		3 PHE A 285
ILE A 266
ASP A 277
 None
 0.75A 5cswB-1kijA:
undetectable		 5cswB-1kijA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1s HYPOTHETICAL PROTEIN
MTH1491

(Methanothermobacter
thermautotrophicus) 		PF02635
(DrsE) 		3 PHE A   8
ILE A  37
ASP A  91
 None
 0.73A 5cswB-1l1sA:
undetectable		 5cswB-1l1sA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 PHE A 303
ILE A 296
ASP A 331
 None
 0.73A 5cswB-1ldjA:
1.4		 5cswB-1ldjA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF00215
(OMPdecase) 		3 PHE A 100
ILE A 135
ASP A 140
 None
 0.66A 5cswB-1losA:
undetectable		 5cswB-1losA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m68 HYPOTHETICAL PROTEIN
YCDX

(Escherichia
coli) 		PF02811
(PHP) 		3 PHE A  35
ILE A  37
ASP A 192
 None
None
ZN  A 302 (-2.6A)
 0.68A 5cswB-1m68A:
undetectable		 5cswB-1m68A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		3 PHE A 147
ILE A 106
ASP A 159
 None
 0.66A 5cswB-1macA:
undetectable		 5cswB-1macA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n27 HEPATOMA-DERIVED
GROWTH FACTOR,
RELATED PROTEIN 3

(Mus musculus) 		PF00855
(PWWP) 		3 PHE A  16
ILE A  88
ASP A  30
 None
 0.72A 5cswB-1n27A:
undetectable		 5cswB-1n27A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		3 PHE B 284
ILE B  55
ASP B 297
 None
None
ZN  B   2 (-2.3A)
 0.58A 5cswB-1n94B:
undetectable		 5cswB-1n94B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1noz DNA POLYMERASE

(Escherichia
virus T4) 		PF03104
(DNA_pol_B_exo1) 		3 PHE A 352
ILE A 209
ASP A 269
 None
 0.71A 5cswB-1nozA:
undetectable		 5cswB-1nozA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5l TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY

(Thermotoga
maritima) 		PF00027
(cNMP_binding) 		3 PHE A 108
ILE A  61
ASP A   2
 None
 0.65A 5cswB-1o5lA:
undetectable		 5cswB-1o5lA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		3 PHE A 164
ILE A 123
ASP A 154
 None
 0.65A 5cswB-1oltA:
undetectable		 5cswB-1oltA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1

(Rattus
norvegicus) 		PF13649
(Methyltransf_25) 		3 PHE A 270
ILE A 272
ASP A 238
 None
 0.46A 5cswB-1or8A:
undetectable		 5cswB-1or8A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7n GAG POLYPROTEIN
CAPSID PROTEIN P27

(Rous sarcoma
virus) 		no annotation 3 PHE A 140
ILE A  60
ASP A  52
 None
 0.65A 5cswB-1p7nA:
undetectable		 5cswB-1p7nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		3 PHE A  68
ILE A  73
ASP A 244
 None
 0.57A 5cswB-1piiA:
undetectable		 5cswB-1piiA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE

(Trichoderma
reesei) 		PF01083
(Cutinase) 		3 PHE A  96
ILE A  95
ASP A 153
 None
 0.73A 5cswB-1qozA:
undetectable		 5cswB-1qozA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r18 PROTEIN-L-ISOASPARTA
TE(D-ASPARTATE)-O-ME
THYLTRANSFERASE

(Drosophila
melanogaster) 		PF01135
(PCMT) 		3 PHE A  96
ILE A  82
ASP A 106
 None
 0.70A 5cswB-1r18A:
undetectable		 5cswB-1r18A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 PHE A 339
ILE A 311
ASP A 101
 None
 0.75A 5cswB-1r6uA:
undetectable		 5cswB-1r6uA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa3 TYPE II RESTRICTION
ENZYME MSPI

(Moraxella sp.) 		PF09208
(Endonuc-MspI) 		3 PHE A  42
ILE A  38
ASP A  84
 None
None
NA  A 401 (-3.2A)
 0.68A 5cswB-1sa3A:
undetectable		 5cswB-1sa3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		3 PHE A 169
ILE A 139
ASP A 165
 None
 0.73A 5cswB-1t0bA:
undetectable		 5cswB-1t0bA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		3 PHE A 481
ILE A 475
ASP A  43
 None
 0.72A 5cswB-1uqwA:
undetectable		 5cswB-1uqwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 PHE A 717
ILE A 644
ASP A 703
 None
 0.43A 5cswB-1xdvA:
undetectable		 5cswB-1xdvA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		3 PHE A 308
ILE A 276
ASP A 151
 None
 0.72A 5cswB-1xe4A:
undetectable		 5cswB-1xe4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		3 PHE A 614
ILE A 595
ASP A 590
 None
 0.74A 5cswB-1xfuA:
undetectable		 5cswB-1xfuA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		3 PHE A 147
ILE A 185
ASP A 130
 None
 0.62A 5cswB-1yaaA:
undetectable		 5cswB-1yaaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqb UBIQUILIN 3

(Homo sapiens) 		PF00240
(ubiquitin) 		3 PHE A  54
ILE A  50
ASP A  59
 None
 0.75A 5cswB-1yqbA:
undetectable		 5cswB-1yqbA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 PHE A 537
ILE A 548
ASP A 541
 None
 0.73A 5cswB-1z1wA:
undetectable		 5cswB-1z1wA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		3 PHE A 490
ILE A 486
ASP A 483
 None
 0.67A 5cswB-2a3lA:
undetectable		 5cswB-2a3lA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a79 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY A
MEMBER 2

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF02214
(BTB_2) 		3 PHE B  78
ILE B  37
ASP B  86
 None
 0.75A 5cswB-2a79B:
undetectable		 5cswB-2a79B:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae8 IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Staphylococcus
aureus) 		PF00475
(IGPD) 		3 PHE A 135
ILE A  68
ASP A  60
 None
 0.55A 5cswB-2ae8A:
undetectable		 5cswB-2ae8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		3 PHE B2181
ILE B2201
ASP B2187
 None
 0.54A 5cswB-2assB:
undetectable		 5cswB-2assB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7y FAVIN BETA CHAIN

(Vicia faba) 		PF00139
(Lectin_legB) 		3 PHE A  64
ILE A  53
ASP A   2
 None
 0.76A 5cswB-2b7yA:
undetectable		 5cswB-2b7yA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		3 PHE A 286
ILE A 273
ASP A 315
 None
 0.55A 5cswB-2c4mA:
undetectable		 5cswB-2c4mA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccm CALEXCITIN

(Doryteuthis
pealeii) 		no annotation 3 PHE A  35
ILE A  65
ASP A 116
 None
 0.76A 5cswB-2ccmA:
undetectable		 5cswB-2ccmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		3 PHE A  22
ILE A  18
ASP A  33
 None
None
NAD  A1251 (-2.7A)
 0.75A 5cswB-2cfcA:
undetectable		 5cswB-2cfcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 PHE A  29
ILE A  45
ASP A 173
 None
 0.64A 5cswB-2cfmA:
undetectable		 5cswB-2cfmA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
CO-CHAPERONE PROTEIN
SBA1

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c)
no annotation 		3 PHE X 121
ILE A 388
ASP X 128
 None
 0.75A 5cswB-2cg9X:
undetectable		 5cswB-2cg9X:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cme HYPOTHETICAL PROTEIN
5

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF09399
(SARS_lipid_bind) 		3 PHE C  92
ILE C  46
ASP C  17
 None
 0.73A 5cswB-2cmeC:
undetectable		 5cswB-2cmeC:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Pyrococcus
horikoshii) 		PF00215
(OMPdecase) 		3 PHE A  87
ILE A 117
ASP A 122
 None
 0.70A 5cswB-2czdA:
undetectable		 5cswB-2czdA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		3 PHE A 199
ILE A 305
ASP A 109
 None
 0.75A 5cswB-2d7sA:
undetectable		 5cswB-2d7sA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		3 PHE A 351
ILE A 134
ASP A 330
 None
 0.72A 5cswB-2eaaA:
undetectable		 5cswB-2eaaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 PHE A  41
ILE A 183
ASP A  11
 None
None
MN  A 501 (-2.5A)
 0.59A 5cswB-2eb0A:
1.2		 5cswB-2eb0A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 PHE A  41
ILE A 183
ASP A  13
 None
None
MN  A 502 (-3.2A)
 0.65A 5cswB-2eb0A:
1.2		 5cswB-2eb0A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebn ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F1

(Elizabethkingia
meningoseptica) 		PF00704
(Glyco_hydro_18) 		3 PHE A 128
ILE A 196
ASP A  40
 None
 0.67A 5cswB-2ebnA:
undetectable		 5cswB-2ebnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eia EIAV CAPSID PROTEIN
P26

(Equine
infectious
anemia virus) 		PF00607
(Gag_p24) 		3 PHE A 106
ILE A 100
ASP A 123
 None
 0.64A 5cswB-2eiaA:
undetectable		 5cswB-2eiaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		3 PHE X 119
ILE X 108
ASP X 158
 None
 0.54A 5cswB-2epkX:
undetectable		 5cswB-2epkX:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651

(Methanocaldococcus
jannaschii) 		PF01887
(SAM_adeno_trans) 		3 PHE A  74
ILE A  14
ASP A   9
 None
 0.66A 5cswB-2f4nA:
undetectable		 5cswB-2f4nA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv5 ADAM 17

(Homo sapiens) 		PF13688
(Reprolysin_5) 		3 PHE A 470
ILE A 462
ASP A 217
 None
 0.65A 5cswB-2fv5A:
undetectable		 5cswB-2fv5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 PHE A 548
ILE A 535
ASP A 469
 None
 0.69A 5cswB-2gepA:
2.6		 5cswB-2gepA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggj N-ACYLAMINO ACID
RACEMASE

(Deinococcus
radiodurans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PHE A  87
ILE A  10
ASP A 116
 None
 0.72A 5cswB-2ggjA:
undetectable		 5cswB-2ggjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gie TYPE II RESTRICTION
ENZYME HINCII

(Haemophilus
influenzae) 		PF09226
(Endonuc-HincII) 		3 PHE A 164
ILE A 166
ASP A 114
 None
 0.66A 5cswB-2gieA:
undetectable		 5cswB-2gieA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5k UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01704
(UDPGP) 		3 PHE A 134
ILE A 126
ASP A 166
 None
 0.73A 5cswB-2i5kA:
undetectable		 5cswB-2i5kA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		3 PHE A  66
ILE A  68
ASP A 108
 None
 0.76A 5cswB-2ichA:
undetectable		 5cswB-2ichA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Arabidopsis
thaliana) 		PF01704
(UDPGP) 		3 PHE A 110
ILE A 102
ASP A 142
 None
 0.67A 5cswB-2icyA:
undetectable		 5cswB-2icyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihd REGULATOR OF
G-PROTEIN SIGNALING
8

(Homo sapiens) 		PF00615
(RGS) 		3 PHE A 112
ILE A 108
ASP A 144
 None
 0.74A 5cswB-2ihdA:
2.9		 5cswB-2ihdA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 PHE A 633
ILE A 694
ASP A 164
 None
 0.73A 5cswB-2ivfA:
undetectable		 5cswB-2ivfA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdz MYB24

(Trichomonas
vaginalis) 		PF13921
(Myb_DNA-bind_6) 		3 PHE A  81
ILE A  78
ASP A  61
 None
 0.69A 5cswB-2kdzA:
undetectable		 5cswB-2kdzA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltl NIFU-LIKE PROTEIN,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF08712
(Nfu_N) 		3 PHE A  32
ILE A 102
ASP A  36
 None
 0.42A 5cswB-2ltlA:
undetectable		 5cswB-2ltlA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9x MICROTUBULE-ASSOCIAT
ED
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF08926
(DUF1908) 		3 PHE A  95
ILE A  49
ASP A  83
 None
 0.76A 5cswB-2m9xA:
undetectable		 5cswB-2m9xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpu RBP1

(Hordeum vulgare) 		PF00076
(RRM_1) 		3 PHE A  52
ILE A  41
ASP A  37
 None
 0.69A 5cswB-2mpuA:
undetectable		 5cswB-2mpuA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nm1 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 PHE A 899
ILE A 909
ASP A 889
 None
 0.68A 5cswB-2nm1A:
undetectable		 5cswB-2nm1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 PHE A 898
ILE A 908
ASP A 888
 None
 0.76A 5cswB-2np0A:
2.1		 5cswB-2np0A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odh R.BCNI

(Brevibacillus
centrosporus) 		PF15515
(MvaI_BcnI) 		3 PHE A  93
ILE A  89
ASP A 200
 None
 0.72A 5cswB-2odhA:
undetectable		 5cswB-2odhA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooi SA0254 PROTEIN

(Staphylococcus
aureus) 		PF07702
(UTRA) 		3 PHE A 221
ILE A  75
ASP A 131
 None
 0.72A 5cswB-2ooiA:
undetectable		 5cswB-2ooiA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2s PUTATIVE
OXIDOREDUCTASE

(Pectobacterium
atrosepticum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 PHE A 119
ILE A 317
ASP A 303
 None
 0.76A 5cswB-2p2sA:
undetectable		 5cswB-2p2sA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4p HYPOTHETICAL PROTEIN
HD1797

([Haemophilus]
ducreyi) 		PF03471
(CorC_HlyC) 		3 PHE A  62
ILE A  37
ASP A  73
 MLY  A  61 ( 4.5A)
None
None
 0.69A 5cswB-2p4pA:
undetectable		 5cswB-2p4pA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfe ALKALINE SERINE
PROTEASE

(Thermobifida
fusca) 		PF00089
(Trypsin) 		3 PHE A 227
ILE A 225
ASP A 219
 GOL  A 403 ( 4.8A)
None
None
 0.74A 5cswB-2pfeA:
2.2		 5cswB-2pfeA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcq BONE MORPHOGENETIC
PROTEIN 3

(Homo sapiens) 		PF00019
(TGF_beta) 		3 PHE A  17
ILE A  85
ASP A  89
 None
 0.72A 5cswB-2qcqA:
undetectable		 5cswB-2qcqA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		3 PHE A   5
ILE A  37
ASP A  46
 None
 0.76A 5cswB-2qt3A:
undetectable		 5cswB-2qt3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		3 PHE A 231
ILE A 155
ASP A 227
 None
NDP  A1523 (-4.5A)
None
 0.76A 5cswB-2vroA:
undetectable		 5cswB-2vroA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		3 PHE A 309
ILE A 361
ASP A 319
 None
 0.73A 5cswB-2wn4A:
undetectable		 5cswB-2wn4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		3 PHE A  87
ILE A  51
ASP A  38
 None
 0.72A 5cswB-2xxlA:
undetectable		 5cswB-2xxlA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 PHE A 765
ILE A 673
ASP A 666
 None
 0.76A 5cswB-2xyuA:
27.9		 5cswB-2xyuA:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y23 MYOMESIN

(Homo sapiens) 		PF07679
(I-set) 		3 PHE A1318
ILE A1301
ASP A1322
 None
 0.70A 5cswB-2y23A:
1.7		 5cswB-2y23A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 PHE A  74
ILE A  49
ASP A  95
 None
 0.66A 5cswB-2y3aA:
2.9		 5cswB-2y3aA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynp COATOMER SUBUNIT
BETA'

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		3 PHE A 455
ILE A 467
ASP A 523
 None
 0.74A 5cswB-2ynpA:
undetectable		 5cswB-2ynpA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvq CARBAMOYL-PHOSPHATE
SYNTHASE

(Homo sapiens) 		PF02142
(MGS) 		3 PHE A1374
ILE A1364
ASP A1396
 None
 0.70A 5cswB-2yvqA:
undetectable		 5cswB-2yvqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zet RAS-RELATED PROTEIN
RAB-27B

(Mus musculus) 		PF00071
(Ras) 		3 PHE A  25
ILE A 131
ASP A  17
 None
 0.75A 5cswB-2zetA:
undetectable		 5cswB-2zetA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus) 		no annotation 3 PHE A 695
ILE A 632
ASP A 688
 None
 0.68A 5cswB-3afbA:
0.6		 5cswB-3afbA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7x FK506-BINDING
PROTEIN 6

(Homo sapiens) 		PF00254
(FKBP_C) 		3 PHE A 110
ILE A 137
ASP A  73
 None
 0.51A 5cswB-3b7xA:
undetectable		 5cswB-3b7xA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt3 GLYOXALASE-RELATED
ENZYME, ARAC TYPE

(Lachnoclostridium
phytofermentans) 		no annotation 3 PHE A 260
ILE A 250
ASP A 237
 None
 0.65A 5cswB-3bt3A:
undetectable		 5cswB-3bt3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		3 PHE A 321
ILE A 415
ASP A 326
 None
 0.73A 5cswB-3cb5A:
undetectable		 5cswB-3cb5A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 PHE A 582
ILE A 577
ASP A 628
 None
 0.72A 5cswB-3ciyA:
undetectable		 5cswB-3ciyA:
16.47