SIMILAR PATTERNS OF AMINO ACIDS FOR 5CPR_B_SAMB402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 GLY A 243
ALA A 241
PHE A 102
SER A 220
GLU A 136
 None
None
CU  A 556 ( 4.9A)
None
None
 1.31A 5cprB-1asoA:
undetectable		 5cprB-1asoA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 GLY A 410
ALA A 412
PHE A 430
CYH A 314
CYH A 374
 None
 1.10A 5cprB-1ex0A:
undetectable		 5cprB-1ex0A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcb GAL6 HG (EMTS)
DERIVATIVE

(Saccharomyces
cerevisiae) 		PF03051
(Peptidase_C1_2) 		5 GLY A 450
ALA A 451
PHE A 416
SER A 325
PHE A 322
 None
 1.18A 5cprB-1gcbA:
undetectable		 5cprB-1gcbA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis) 		PF01347
(Vitellogenin_N)
PF09172
(DUF1943) 		5 GLY A 481
ALA A 479
HIS A 746
TYR A 194
GLU A 675
 None
None
PLD  A2007 ( 3.9A)
PLD  A2005 (-4.4A)
None
 1.40A 5cprB-1lshA:
undetectable		 5cprB-1lshA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oki BETA CRYSTALLIN B1

(Homo sapiens) 		PF00030
(Crystall) 		5 GLY A  56
SER A  96
PHE A 138
CYH A  79
GLU A  78
 None
 1.42A 5cprB-1okiA:
undetectable		 5cprB-1okiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 PHE A 239
HIS A 242
TYR A 283
CYH A 306
CYH A 308
 None
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
 1.21A 5cprB-1pegA:
6.6		 5cprB-1pegA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzx HYPOTHETICAL PROTEIN
APC36103

(Geobacillus
stearothermophilus) 		PF02645
(DegV) 		5 GLY A 268
ALA A 266
SER A 261
PHE A 279
CYH A 121
 None
PLM  A 702 ( 4.6A)
None
None
None
 1.49A 5cprB-1pzxA:
undetectable		 5cprB-1pzxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 153
GLY A 154
ALA A 192
HIS A 171
CYH A 139
 None
 1.45A 5cprB-1rvkA:
undetectable		 5cprB-1rvkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 GLY A 256
ALA A 255
SER A  55
PHE A  38
GLU A  37
 None
 1.18A 5cprB-1vb3A:
undetectable		 5cprB-1vb3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLU A 201
GLY A 178
ALA A 177
PHE A 202
GLU A 219
 None
 1.49A 5cprB-2a8xA:
undetectable		 5cprB-2a8xA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq2 HYPOTHETICAL PROTEIN
LOC91801

(Homo sapiens) 		PF00076
(RRM_1) 		5 TYR A  87
ALA A  73
PHE A  84
SER A  83
CYH A  68
 None
 1.39A 5cprB-2cq2A:
undetectable		 5cprB-2cq2A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		5 GLY A 463
ALA A 341
PHE A 315
SER A 336
GLU A 303
 None
 1.47A 5cprB-2dpgA:
undetectable		 5cprB-2dpgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		5 TYR A  80
GLY A  79
ALA A  82
SER A 429
GLU A 400
 None
None
None
HEM  A 500 (-2.9A)
None
 1.41A 5cprB-2nnjA:
undetectable		 5cprB-2nnjA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 PHE A 217
HIS A 220
TYR A 261
CYH A 287
CYH A 289
 None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
 1.31A 5cprB-2r3aA:
7.4		 5cprB-2r3aA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		5 GLY A  63
ALA A  58
SER A  18
HIS A  24
GLU A 119
 None
 1.42A 5cprB-2rgjA:
undetectable		 5cprB-2rgjA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 PHE A3904
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 1.38A 5cprB-2w5zA:
7.4		 5cprB-2w5zA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 PHE A 207
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 1.45A 5cprB-3bo5A:
7.2		 5cprB-3bo5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF13377
(Peripla_BP_3) 		5 GLY A 226
ALA A 227
SER A 256
PHE A 190
GLU A 222
 None
 1.27A 5cprB-3e3mA:
undetectable		 5cprB-3e3mA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 GLY A 131
ALA A 132
SER A 310
PHE A 403
GLU A 402
 None
 1.39A 5cprB-3k1dA:
undetectable		 5cprB-3k1dA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqi PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		no annotation 5 GLY A 100
PHE A 212
HIS A 169
TYR A 151
PHE A 171
 None
PEG  A 329 (-4.8A)
None
None
None
 1.26A 5cprB-3nqiA:
undetectable		 5cprB-3nqiA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		5 PHE A2215
HIS A2218
TYR A2255
CYH A2268
CYH A2270
 None
None
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 1.34A 5cprB-3opeA:
7.4		 5cprB-3opeA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 TYR A 527
ALA A 523
PHE A 555
SER A 245
GLU A 531
 None
 1.50A 5cprB-3welA:
undetectable		 5cprB-3welA:
15.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4au7 HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2

(Mus musculus) 		PF00856
(SET) 		5 GLY A 156
SER A 161
HIS A 183
TYR A 217
CYH A 229
 None
None
SAH  A1247 (-4.6A)
None
ZN  A1248 ( 2.3A)
 1.26A 5cprB-4au7A:
33.4		 5cprB-4au7A:
60.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4au7 HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2

(Mus musculus) 		PF00856
(SET) 		12 TYR A 114
GLU A 117
GLY A 120
ALA A 121
PHE A 160
SER A 161
HIS A 183
TYR A 217
PHE A 222
CYH A 229
GLU A 230
CYH A 231
 SAH  A1247 ( 3.6A)
SAH  A1247 (-2.8A)
SAH  A1247 (-3.2A)
SAH  A1247 (-4.1A)
None
None
SAH  A1247 (-4.6A)
None
SAH  A1247 (-4.0A)
ZN  A1248 ( 2.3A)
EDO  A1251 ( 2.8A)
ZN  A1248 ( 2.2A)
 0.47A 5cprB-4au7A:
33.4		 5cprB-4au7A:
60.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4au7 HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2

(Mus musculus) 		PF00856
(SET) 		8 TYR A 114
GLU A 117
GLY A 120
PHE A 160
SER A 161
HIS A 183
TYR A 217
CYH A 231
 SAH  A1247 ( 3.6A)
SAH  A1247 (-2.8A)
SAH  A1247 (-3.2A)
None
None
SAH  A1247 (-4.6A)
None
ZN  A1248 ( 2.2A)
 1.47A 5cprB-4au7A:
33.4		 5cprB-4au7A:
60.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4au7 HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2

(Mus musculus) 		PF00856
(SET) 		8 TYR A 114
GLU A 117
GLY A 120
SER A 161
HIS A 183
TYR A 217
GLU A 230
CYH A 229
 SAH  A1247 ( 3.6A)
SAH  A1247 (-2.8A)
SAH  A1247 (-3.2A)
None
SAH  A1247 (-4.6A)
None
EDO  A1251 ( 2.8A)
ZN  A1248 ( 2.3A)
 1.50A 5cprB-4au7A:
33.4		 5cprB-4au7A:
60.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 GLY A 322
SER A 416
HIS A 299
CYH A 409
GLU A 408
 None
 1.33A 5cprB-4bqhA:
undetectable		 5cprB-4bqhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkv ALCOHOL
DEHYDROGENASE,
PROPANOL-PREFERRING

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  62
ALA A  80
HIS A  58
CYH A  37
CYH A 145
 None
None
ZN  A 402 (-3.3A)
ZN  A 402 ( 2.4A)
ZN  A 402 ( 2.3A)
 1.37A 5cprB-4gkvA:
undetectable		 5cprB-4gkvA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A  12
ALA A  85
SER A 191
PHE A  57
GLU A  61
 None
 1.49A 5cprB-4jb6A:
undetectable		 5cprB-4jb6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 TYR A 235
GLY A 233
HIS A 225
PHE A 622
GLU A 620
 None
 1.21A 5cprB-4l37A:
undetectable		 5cprB-4l37A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 GLY A 117
ALA A 115
HIS A  12
GLU A  17
CYH A  16
 None
 1.47A 5cprB-4lfeA:
undetectable		 5cprB-4lfeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  70
ALA A  88
HIS A  66
CYH A  43
CYH A 153
 None
None
ZN  A 401 ( 3.1A)
ZN  A 401 (-2.2A)
ZN  A 401 (-2.3A)
 1.30A 5cprB-4w6zA:
undetectable		 5cprB-4w6zA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		5 GLU A 268
GLY A 267
ALA A 266
SER A 209
TYR A 116
 None
 1.38A 5cprB-4xdoA:
undetectable		 5cprB-4xdoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A  58
ALA A  57
PHE A  88
SER A  63
PHE A 135
 None
None
None
None
BGC  A 802 (-4.3A)
 1.35A 5cprB-4zo6A:
undetectable		 5cprB-4zo6A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a) 		5 TYR C 788
GLY C 786
PHE C 790
PHE C 826
CYH C 825
 None
 1.50A 5cprB-5a6fC:
undetectable		 5cprB-5a6fC:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 5 TYR A 388
ALA A 392
PHE A 275
HIS A 128
CYH A 376
 None
 1.47A 5cprB-5ah0A:
undetectable		 5cprB-5ah0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		5 TYR A 211
GLY A 164
ALA A 208
PHE A 238
PHE A 222
 None
 1.30A 5cprB-5by3A:
undetectable		 5cprB-5by3A:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cpr HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1

(Homo sapiens) 		PF00856
(SET) 		12 TYR B 203
GLU B 206
GLY B 209
ALA B 210
PHE B 250
SER B 251
HIS B 273
TYR B 307
PHE B 312
CYH B 319
GLU B 320
CYH B 321
 SAM  B 402 (-3.7A)
SAM  B 402 (-2.9A)
SAM  B 402 (-3.4A)
SAM  B 402 (-3.9A)
None
SAM  B 402 (-3.9A)
SAM  B 402 (-4.5A)
539  B 403 ( 3.9A)
SAM  B 402 (-3.7A)
ZN  B 401 ( 2.3A)
SAM  B 402 (-4.6A)
ZN  B 401 ( 2.2A)
 0.01A 5cprB-5cprB:
41.8		 5cprB-5cprB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 GLY A  36
ALA A  35
SER A 215
TYR A 190
GLU A  42
 GLY  A  36 ( 0.0A)
ALA  A  35 ( 0.0A)
SER  A 215 ( 0.0A)
TYR  A 190 ( 1.3A)
GLU  A  42 ( 0.6A)
 1.31A 5cprB-5d7wA:
undetectable		 5cprB-5d7wA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		5 PHE A3904
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 1.44A 5cprB-5f6lA:
8.6		 5cprB-5f6lA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnw BLR0248 PROTEIN

(Bradyrhizobium
diazoefficiens) 		no annotation 5 TYR C 118
GLY C 114
ALA C  26
PHE C  96
CYH C  18
 None
 1.28A 5cprB-5gnwC:
undetectable		 5cprB-5gnwC:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		5 GLY B 352
ALA B 354
PHE B 319
PHE B 372
CYH B 425
 None
 1.38A 5cprB-5iklB:
undetectable		 5cprB-5iklB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		5 PHE A1139
HIS A1142
TYR A1179
CYH A1191
CYH A1193
 SAM  A1304 (-4.7A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
 1.41A 5cprB-5lsuA:
7.9		 5cprB-5lsuA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 TYR A 341
GLU A 343
ALA A 556
SER A 400
CYH A 549
 None
 1.30A 5cprB-5n94A:
undetectable		 5cprB-5n94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus) 		PF01058
(Oxidored_q6)
PF00374
(NiFeSe_Hases) 		5 GLU E  57
GLY E  58
SER E  18
CYH F 442
CYH F 445
 SF4  E 302 (-3.8A)
SF4  E 302 ( 4.9A)
None
NFU  F 501 (-2.2A)
NFU  F 501 (-2.4A)
 1.29A 5cprB-5odrE:
undetectable		 5cprB-5odrE:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 PHE A1110
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 None
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 1.38A 5cprB-5tuyA:
8.0		 5cprB-5tuyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 PHE A1198
HIS A1201
TYR A1242
CYH A1256
CYH A1258
 None
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
 1.36A 5cprB-5vsdA:
9.5		 5cprB-5vsdA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE
NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus;
Hydrogenophilus
thermoluteolus) 		PF01058
(Oxidored_q6)
PF00374
(NiFeSe_Hases) 		5 GLU C  67
GLY C  68
SER C  30
CYH D 462
CYH D 465
 SF4  C 201 ( 3.6A)
SF4  C 201 ( 4.5A)
None
NI  D 502 ( 2.3A)
FCO  D 501 ( 2.3A)
 1.24A 5cprB-5xfaC:
undetectable		 5cprB-5xfaC:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhh UNCHARACTERIZED
CONSERVED PROTEIN
YIIM

(Geobacillus
stearothermophilus) 		no annotation 5 TYR A  62
GLU A  85
GLY A  81
ALA A  80
PHE A 143
 None
 1.25A 5cprB-5yhhA:
undetectable		 5cprB-5yhhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 5 PHE A1221
HIS A1224
TYR A1261
CYH A1273
CYH A1275
 None
None
SAM  A1301 (-4.9A)
ZN  A1304 ( 2.3A)
ZN  A1304 (-2.3A)
 1.42A 5cprB-6cenA:
7.3		 5cprB-6cenA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fu4 PROBABLE CHEMOTAXIS
TRANSDUCER

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 200
PHE A 224
SER A  84
PHE A 129
GLU A 130
 None
 1.16A 5cprB-6fu4A:
undetectable		 5cprB-6fu4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		3 HIS A 130
SER A 167
ASN A 186
 None
 0.71A 5cprB-1bxkA:
0.0		 5cprB-1bxkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		3 HIS A 129
SER A 174
ASN A 193
 None
 0.69A 5cprB-1g1aA:
0.0		 5cprB-1g1aA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 451
SER A 349
ASN A  83
 CU  A 702 (-3.2A)
None
None
 0.79A 5cprB-1hfuA:
0.0		 5cprB-1hfuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 602
SER A 629
ASN A 632
 CU  A1054 ( 3.4A)
None
None
 0.66A 5cprB-1kcwA:
undetectable		 5cprB-1kcwA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		3 HIS A 656
SER A 360
ASN A 430
 None
 0.88A 5cprB-1kspA:
0.0		 5cprB-1kspA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 HIS A  59
SER A  64
ASN A 157
 ZN  A 501 (-3.5A)
None
None
 0.83A 5cprB-1nfgA:
0.0		 5cprB-1nfgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		3 HIS A 592
SER A 595
ASN A 627
 None
 0.77A 5cprB-1o94A:
0.0		 5cprB-1o94A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oc2 DTDP-GLUCOSE
4,6-DEHYDRATASE

(Streptococcus
suis) 		PF16363
(GDP_Man_Dehyd) 		3 HIS A 121
SER A 168
ASN A 187
 None
 0.86A 5cprB-1oc2A:
0.0		 5cprB-1oc2A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		3 HIS A 316
SER A 379
ASN A 306
 None
 0.78A 5cprB-1pvgA:
0.0		 5cprB-1pvgA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		3 HIS A 101
SER A 138
ASN A  57
 None
None
PLP  A1229 (-3.0A)
 0.88A 5cprB-1w8gA:
undetectable		 5cprB-1w8gA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 HIS A 431
SER A 406
ASN A 434
 None
 0.61A 5cprB-1xfdA:
undetectable		 5cprB-1xfdA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA
ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens;
Mus musculus) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		3 HIS E 254
SER E 331
ASN A 377
 None
 0.57A 5cprB-1xlsE:
undetectable		 5cprB-1xlsE:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkp HYPOTHETICAL PROTEIN
BA1088

(Bacillus
anthracis) 		PF12706
(Lactamase_B_2) 		3 HIS A  61
SER A  20
ASN A 177
 ZN  A 245 (-3.1A)
ZN  A 246 ( 4.8A)
None
 0.89A 5cprB-1zkpA:
undetectable		 5cprB-1zkpA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME

(Homo sapiens) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		3 HIS A 325
SER A 390
ASN A 315
 None
 0.90A 5cprB-1zxnA:
undetectable		 5cprB-1zxnA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		3 HIS A 146
SER A 121
ASN A 151
 None
 0.79A 5cprB-2bi3A:
undetectable		 5cprB-2bi3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3y URACIL-DNA
GLYCOSYLASE

(Thermus
thermophilus) 		PF03167
(UDG) 		3 HIS A  63
SER A  77
ASN A 120
 None
ACT  A 222 ( 4.2A)
None
 0.82A 5cprB-2d3yA:
undetectable		 5cprB-2d3yA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flq NITRIC OXIDE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF02898
(NO_synthase) 		3 HIS A 134
SER A 152
ASN A 253
 None
None
ARG  A 376 (-2.9A)
 0.89A 5cprB-2flqA:
undetectable		 5cprB-2flqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 HIS A 347
SER A 214
ASN A 264
 None
 0.81A 5cprB-2fuqA:
undetectable		 5cprB-2fuqA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz0 V-SNARE COMPONENT OF
THE VACUOLAR SNARE
COMPLEX INVOLVED IN
VESICLE FUSION
INHIBITS
ATP-DEPENDENT CA(2+)
TRANSPORT ACTIVITY
OF PMC1P IN THE
VACUOLAR MEMBRANE
NYV1P

(Saccharomyces
cerevisiae) 		PF09426
(Nyv1_N) 		3 HIS A  86
SER A  82
ASN A 118
 None
 0.88A 5cprB-2fz0A:
undetectable		 5cprB-2fz0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g18 PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE

(Anabaena sp.) 		PF05996
(Fe_bilin_red) 		3 HIS A 121
SER A 156
ASN A 131
 None
 0.87A 5cprB-2g18A:
undetectable		 5cprB-2g18A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		3 HIS A  71
SER A 252
ASN A 168
 PMS  A 601 (-3.1A)
None
PMS  A 601 (-3.0A)
 0.90A 5cprB-2gkoA:
undetectable		 5cprB-2gkoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdk ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR-LIKE
PROTEIN 2

(Homo sapiens) 		PF14598
(PAS_11) 		3 HIS A 369
SER A 398
ASN A 364
 None
 0.84A 5cprB-2kdkA:
undetectable		 5cprB-2kdkA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvz PRPF METHYLACONITATE
ISOMERASE

(Shewanella
oneidensis) 		PF04303
(PrpF) 		3 HIS A 355
SER A 312
ASN A 109
 None
CA  A1003 (-3.2A)
EDO  A1005 (-4.0A)
 0.90A 5cprB-2pvzA:
undetectable		 5cprB-2pvzA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  55
SER A  89
ASN A  12
 None
 0.62A 5cprB-2qt6A:
undetectable		 5cprB-2qt6A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmj DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 HIS A 231
SER A 137
ASN A 207
 None
 0.81A 5cprB-2vmjA:
undetectable		 5cprB-2vmjA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00657
(Lipase_GDSL) 		3 HIS A 310
SER A 157
ASN A 220
 BGC  A1338 (-4.0A)
None
None
 0.81A 5cprB-2wabA:
undetectable		 5cprB-2wabA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Sus scrofa) 		PF13561
(adh_short_C2) 		3 HIS A  71
SER A  97
ASN A 123
 NAP  A1261 ( 3.6A)
None
None
 0.92A 5cprB-2zatA:
undetectable		 5cprB-2zatA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Staphylococcus
aureus) 		PF13460
(NAD_binding_10) 		3 HIS A 248
SER A 118
ASN A 112
 None
 0.88A 5cprB-3e48A:
undetectable		 5cprB-3e48A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 219
SER A  86
ASN A 369
 CU  A 696 (-3.3A)
None
None
 0.71A 5cprB-3hhsA:
undetectable		 5cprB-3hhsA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i93 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00692
(dUTPase) 		3 HIS A  62
SER A  74
ASN A  77
 None
TRS  A 202 (-3.0A)
DUP  A 201 (-3.2A)
 0.89A 5cprB-3i93A:
undetectable		 5cprB-3i93A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		3 HIS A 716
SER A 720
ASN A1091
 None
 0.90A 5cprB-3jclA:
undetectable		 5cprB-3jclA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NUCLEAR RNA EXPORT
FACTOR 2
NTF2-RELATED EXPORT
PROTEIN

(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		no annotation
PF02136
(NTF2) 		3 HIS A 337
SER A 383
ASN B  98
 None
None
NA  B 452 (-4.1A)
 0.80A 5cprB-3nv0A:
undetectable		 5cprB-3nv0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Homo sapiens) 		PF13561
(adh_short_C2) 		3 HIS A  89
SER A 115
ASN A 141
 NAP  A 601 ( 3.6A)
None
None
 0.91A 5cprB-3o4rA:
undetectable		 5cprB-3o4rA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr6 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacteroides
abscessus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		3 HIS A 113
SER A 253
ASN A 190
 None
None
PEG  A 266 (-3.9A)
 0.81A 5cprB-3rr6A:
undetectable		 5cprB-3rr6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6b METHIONINE
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24) 		3 HIS A 284
SER A 330
ASN A 206
 None
 0.82A 5cprB-3s6bA:
undetectable		 5cprB-3s6bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 458
SER A 207
ASN A 267
 CU  A 501 (-3.3A)
None
None
 0.87A 5cprB-3t6wA:
undetectable		 5cprB-3t6wA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE

(Coxiella
burnetii) 		PF00809
(Pterin_bind) 		3 HIS A 155
SER A 233
ASN A 214
 None
 0.73A 5cprB-3tr9A:
undetectable		 5cprB-3tr9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		3 HIS A 535
SER A 497
ASN A 543
 None
 0.87A 5cprB-3ui7A:
1.4		 5cprB-3ui7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA

(Streptomyces
lividans) 		PF00266
(Aminotran_5) 		3 HIS A  99
SER A 144
ASN A  74
 PLP  A 400 (-3.7A)
None
None
 0.86A 5cprB-3vaxA:
undetectable		 5cprB-3vaxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE

(Ascaris suum;
Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13534
(Fer4_17) 		3 HIS A 250
SER A 541
ASN B  77
 None
 0.70A 5cprB-3vrbA:
undetectable		 5cprB-3vrbA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1

(Lupinus luteus) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		3 HIS A 509
SER A 442
ASN A 490
 None
 0.84A 5cprB-3zk4A:
undetectable		 5cprB-3zk4A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 HIS A 295
SER A 401
ASN A  34
 None
 0.79A 5cprB-3zo9A:
undetectable		 5cprB-3zo9A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 HIS A 135
SER A  70
ASN A 317
 None
 0.89A 5cprB-3zyvA:
undetectable		 5cprB-3zyvA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 HIS A  73
SER A 289
ASN A 103
 None
 0.84A 5cprB-4adeA:
undetectable		 5cprB-4adeA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		3 HIS A1091
SER A1186
ASN A1135
 None
 0.68A 5cprB-4amcA:
undetectable		 5cprB-4amcA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 HIS A 319
SER A 363
ASN A 270
 None
 0.87A 5cprB-4arxA:
undetectable		 5cprB-4arxA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		3 HIS A 122
SER A 159
ASN A 196
 GAL  A1233 (-3.5A)
None
None
 0.86A 5cprB-4ayjA:
undetectable		 5cprB-4ayjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cza NA+/H+ ANTIPORTER,
PUTATIVE

(Pyrococcus
abyssi) 		PF00999
(Na_H_Exchanger) 		3 HIS A 388
SER A 320
ASN A 314
 None
 0.85A 5cprB-4czaA:
undetectable		 5cprB-4czaA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dy0 GLIA-DERIVED NEXIN

(Homo sapiens) 		PF00079
(Serpin) 		3 HIS A 364
SER A  35
ASN A  77
 None
 0.90A 5cprB-4dy0A:
undetectable		 5cprB-4dy0A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuk METHIONINE
AMINOPEPTIDASE

(Trypanosoma
brucei) 		PF00557
(Peptidase_M24) 		3 HIS A 299
SER A 345
ASN A 224
 None
None
ZN  A 402 ( 4.9A)
 0.84A 5cprB-4fukA:
undetectable		 5cprB-4fukA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN
MGC81050 PROTEIN

(Xenopus laevis;
Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C)
PF00400
(WD40) 		3 HIS B 114
SER A 230
ASN B 154
 None
 0.76A 5cprB-4g56B:
undetectable		 5cprB-4g56B:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		3 HIS A 316
SER A 379
ASN A 306
 None
 0.78A 5cprB-4gfhA:
undetectable		 5cprB-4gfhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE

(Photorhabdus
laumondii) 		PF01494
(FAD_binding_3) 		3 HIS A 320
SER A 300
ASN A 370
 None
 0.75A 5cprB-4hb9A:
undetectable		 5cprB-4hb9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		3 HIS A 356
SER A 364
ASN A 359
 None
None
GOL  A 502 (-4.2A)
 0.91A 5cprB-4hn8A:
undetectable		 5cprB-4hn8A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 HIS A 317
SER A 363
ASN A 242
 None
 0.82A 5cprB-4hxxA:
undetectable		 5cprB-4hxxA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyr GLUCARATE
DEHYDRATASE

(Acidaminococcus
intestini) 		PF13378
(MR_MLE_C) 		3 HIS A 335
SER A 343
ASN A 338
 None
 0.92A 5cprB-4hyrA:
undetectable		 5cprB-4hyrA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		3 HIS A 100
SER A 148
ASN A  73
 LLP  A 205 ( 3.6A)
None
None
 0.81A 5cprB-4isyA:
undetectable		 5cprB-4isyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		3 HIS A 317
SER A 363
ASN A 242
 None
 0.84A 5cprB-4iu6A:
undetectable		 5cprB-4iu6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb8 DARPIN C7_16

(synthetic
construct) 		PF12796
(Ank_2) 		3 HIS P  52
SER P  23
ASN P  44
 None
 0.91A 5cprB-4jb8P:
undetectable		 5cprB-4jb8P:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mee DIFFUSE ADHERENCE
ADHESIN

(Escherichia
coli) 		PF03797
(Autotransporter) 		3 HIS A1271
SER A1240
ASN A1274
 None
 0.66A 5cprB-4meeA:
undetectable		 5cprB-4meeA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9f VIRION INFECTIVITY
FACTOR

(Human
immunodeficiency
virus 1) 		no annotation 3 HIS b  80
SER b  52
ASN b  19
 None
 0.71A 5cprB-4n9fb:
undetectable		 5cprB-4n9fb:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh COPN
CHAPERONE SYCD

(Chlamydia
pneumoniae;
Chlamydia
pneumoniae) 		PF07201
(HrpJ)
PF07720
(TPR_3) 		3 HIS B  63
SER B  93
ASN A 197
 None
 0.82A 5cprB-4nrhB:
undetectable		 5cprB-4nrhB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF00171
(Aldedh) 		3 HIS A 349
SER A 197
ASN A 297
 None
 0.84A 5cprB-4ou2A:
undetectable		 5cprB-4ou2A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Sulfurospirillum
deleyianum) 		PF03480
(DctP) 		3 HIS A  30
SER A  88
ASN A 211
 None
SIN  A 401 ( 3.5A)
SIN  A 401 (-3.3A)
 0.90A 5cprB-4ovsA:
undetectable		 5cprB-4ovsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		3 HIS A  54
SER A 384
ASN A 388
 None
 0.74A 5cprB-4rnxA:
undetectable		 5cprB-4rnxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 HIS A 319
SER A 363
ASN A 270
 None
 0.84A 5cprB-4w8jA:
undetectable		 5cprB-4w8jA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 HIS A 287
SER A 340
ASN A 279
 None
 0.89A 5cprB-4wsqA:
undetectable		 5cprB-4wsqA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 HIS A 301
SER A 233
ASN A 269
 ZN  A 901 ( 3.2A)
None
None
 0.86A 5cprB-4xmvA:
undetectable		 5cprB-4xmvA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 223
SER A  97
ASN A 380
 CU  A 801 (-3.0A)
None
None
 0.91A 5cprB-4yzwA:
undetectable		 5cprB-4yzwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 227
SER A  97
ASN A 380
 CU  A 801 (-3.2A)
None
None
 0.84A 5cprB-4yzwA:
undetectable		 5cprB-4yzwA:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cpr HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1

(Homo sapiens) 		PF00856
(SET) 		3 HIS B  98
SER B 205
ASN B 272
 SAM  B 402 (-3.7A)
SAM  B 402 (-2.7A)
SAM  B 402 (-3.1A)
 0.01A 5cprB-5cprB:
41.8		 5cprB-5cprB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 HIS A 306
SER A 242
ASN A 278
 ZN  A 901 (-3.3A)
None
None
 0.87A 5cprB-5dllA:
undetectable		 5cprB-5dllA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4e IZUMO SPERM-EGG
FUSION PROTEIN 1

(Homo sapiens) 		PF15005
(IZUMO)
PF16706
(Izumo-Ig) 		3 HIS A 157
SER A 190
ASN A 239
 None
 0.89A 5cprB-5f4eA:
undetectable		 5cprB-5f4eA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjq CARBOHYDRATE BINDING
PROTEIN, PUTATIVE,
CPB33A

(Cellvibrio
japonicus) 		PF03067
(LPMO_10) 		3 HIS A 178
SER A  41
ASN A 132
 None
 0.92A 5cprB-5fjqA:
undetectable		 5cprB-5fjqA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 3 HIS C 196
SER C 162
ASN C 414
 None
 0.82A 5cprB-5gp4C:
undetectable		 5cprB-5gp4C:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		3 HIS A 705
SER A 675
ASN A 689
 None
 0.66A 5cprB-5gz4A:
undetectable		 5cprB-5gz4A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig4 PREDICTED PROTEIN

(Nematostella
vectensis) 		PF08332
(CaMKII_AD) 		3 HIS A 395
SER A 360
ASN A 464
 None
 0.78A 5cprB-5ig4A:
undetectable		 5cprB-5ig4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig5 CAMKII-B HUB

(Nematostella
vectensis) 		PF08332
(CaMKII_AD) 		3 HIS A 395
SER A 360
ASN A 464
 None
 0.83A 5cprB-5ig5A:
undetectable		 5cprB-5ig5A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1k TOXR-ACTIVATED GENE
(TAGE)

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		3 HIS A 218
SER A 239
ASN A 192
 None
 0.91A 5cprB-5j1kA:
undetectable		 5cprB-5j1kA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kte DIVALENT METAL
CATION TRANSPORTER
MNTH

(Deinococcus
radiodurans) 		PF01566
(Nramp) 		3 HIS A 232
SER A 377
ASN A  59
 None
 0.84A 5cprB-5kteA:
undetectable		 5cprB-5kteA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		3 HIS A1128
SER A1014
ASN A1304
 None
 0.88A 5cprB-5lkiA:
undetectable		 5cprB-5lkiA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m45 ACETONE CARBOXYLASE
BETA SUBUNIT

(Xanthobacter
autotrophicus) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		3 HIS B 184
SER B 215
ASN B  99
 None
 0.88A 5cprB-5m45B:
undetectable		 5cprB-5m45B:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 3 HIS A 245
SER A 108
ASN A 157
 None
 0.85A 5cprB-5m86A:
undetectable		 5cprB-5m86A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH

(Staphylococcus
capitis) 		PF01566
(Nramp) 		3 HIS A 228
SER A 388
ASN A  52
 None
None
MN  A 501 (-3.0A)
 0.87A 5cprB-5m95A:
undetectable		 5cprB-5m95A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 458
SER A 207
ASN A 267
 CU  A 504 (-3.1A)
None
None
 0.90A 5cprB-5mewA:
undetectable		 5cprB-5mewA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF04616
(Glyco_hydro_43) 		3 HIS A  76
SER A 430
ASN A 364
 None
 0.70A 5cprB-5msxA:
undetectable		 5cprB-5msxA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 HIS A 596
SER A 623
ASN A 626
 None
 0.68A 5cprB-5n4lA:
undetectable		 5cprB-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 3 HIS C  26
SER C 420
ASN C 466
 None
 0.91A 5cprB-5o4gC:
undetectable		 5cprB-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Homo sapiens;
Homo sapiens) 		PF06093
(Spt4)
PF00467
(KOW)
PF03439
(Spt5-NGN) 		3 HIS Y  12
SER Y  56
ASN Z 301
 None
 0.81A 5cprB-5oikY:
undetectable		 5cprB-5oikY:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 HIS T2091
SER T2005
ASN T  39
 None
 0.88A 5cprB-5ojsT:
undetectable		 5cprB-5ojsT:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1

(Leeuwenhoekiella
blandensis) 		no annotation 3 HIS A 209
SER A 167
ASN A 217
 None
 0.66A 5cprB-5olkA:
undetectable		 5cprB-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 HIS A 798
SER A 325
ASN A 795
 None
 0.80A 5cprB-5t9gA:
undetectable		 5cprB-5t9gA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Vibrio cholerae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 HIS A 165
SER A  63
ASN A 168
 None
 0.87A 5cprB-5tr7A:
undetectable		 5cprB-5tr7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		3 HIS A 186
SER A 192
ASN A 269
 None
 0.88A 5cprB-5u1sA:
undetectable		 5cprB-5u1sA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xox TRNA(HIS)
GUANYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF04446
(Thg1)
PF14413
(Thg1C) 		3 HIS A  34
SER A  76
ASN A 161
 GTP  A 301 (-4.2A)
GTP  A 301 (-3.9A)
None
 0.83A 5cprB-5xoxA:
undetectable		 5cprB-5xoxA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 3 HIS A 397
SER A 431
ASN A 425
 None
 0.81A 5cprB-6bpcA:
undetectable		 5cprB-6bpcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Mus musculus) 		no annotation 3 HIS A 391
SER A 394
ASN A 338
 None
 0.83A 5cprB-6brkA:
undetectable		 5cprB-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 3 HIS A 786
SER A 791
ASN A 373
 None
 0.91A 5cprB-6bv2A:
undetectable		 5cprB-6bv2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 3 HIS A 313
SER A 374
ASN A 202
 None
 0.68A 5cprB-6cgmA:
undetectable		 5cprB-6cgmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1
POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		3 HIS D  48
SER A1173
ASN A1016
 None
 0.92A 5cprB-6eojD:
undetectable		 5cprB-6eojD:
18.65