SIMILAR PATTERNS OF AMINO ACIDS FOR 5CG5_A_RISA400_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		7 LEU A 114
ARG A 126
THR A 181
GLN A 185
LYS A 214
THR A 215
TYR A 218
 None
 0.93A 5cg5A-1fpsA:
44.7		 5cg5A-1fpsA:
69.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 LEU A 114
ARG A 126
THR A 215
TYR A 218
GLN A 254
 None
 0.83A 5cg5A-1fpsA:
44.7		 5cg5A-1fpsA:
69.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		7 LEU A 114
ASP A 117
ARG A 126
THR A 181
GLN A 185
THR A 215
TYR A 218
 None
 0.80A 5cg5A-1fpsA:
44.7		 5cg5A-1fpsA:
69.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		5 LEU A 305
ASP A 302
THR A   7
TYR A 164
ASP A  32
 None
None
None
None
ZN  A1457 (-1.9A)
 1.09A 5cg5A-1ibqA:
undetectable		 5cg5A-1ibqA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.35A 5cg5A-1rqjA:
29.2		 5cg5A-1rqjA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  82
ARG A  93
GLN A 154
THR A 178
 None
 1.14A 5cg5A-1rtrA:
25.0		 5cg5A-1rtrA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  88
ARG A  93
GLN A 154
THR A 178
 None
 0.71A 5cg5A-1rtrA:
25.0		 5cg5A-1rtrA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  88
ARG A  93
THR A 178
GLN A 215
 None
 0.82A 5cg5A-1rtrA:
25.0		 5cg5A-1rtrA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxo YDEN PROTEIN

(Bacillus
subtilis) 		PF06821
(Ser_hydrolase) 		5 LEU A  37
ASP A  35
THR A  65
GLN A   4
THR A  60
 None
 1.06A 5cg5A-1uxoA:
undetectable		 5cg5A-1uxoA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		6 LEU A  76
ARG A  88
THR A 142
TYR A 176
GLN A 209
ASP A 212
 None
 0.85A 5cg5A-1wmwA:
31.6		 5cg5A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		6 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
 None
 1.31A 5cg5A-1wmwA:
31.6		 5cg5A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		6 LEU A  76
ASP A  79
ASP A  83
ARG A  88
TYR A 176
GLN A 209
 None
 0.92A 5cg5A-1wmwA:
31.6		 5cg5A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		6 LEU A  76
ASP A  83
ARG A  88
THR A 142
GLN A 146
GLN A 209
 None
 0.91A 5cg5A-1wmwA:
31.6		 5cg5A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		6 LEU A  76
ASP A  83
ARG A  88
THR A 142
TYR A 176
GLN A 209
 None
 0.52A 5cg5A-1wmwA:
31.6		 5cg5A-1wmwA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		5 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.64A 5cg5A-1wy0A:
28.1		 5cg5A-1wy0A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8a HYPOTHETICAL PROTEIN
AF1437

(Archaeoglobus
fulgidus) 		no annotation 5 LEU A  58
ASP A  37
THR A 126
TYR A 106
ASP A  14
 None
 1.22A 5cg5A-1y8aA:
undetectable		 5cg5A-1y8aA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		6 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.40A 5cg5A-2azkA:
22.5		 5cg5A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		6 LEU A  78
ASP A  81
ARG A  90
THR A 139
THR A 161
GLN A 197
 None
 1.01A 5cg5A-2azkA:
22.5		 5cg5A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		6 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 1.02A 5cg5A-2azkA:
22.5		 5cg5A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		6 LEU A  78
ASP A  85
ARG A  90
THR A 139
THR A 161
GLN A 197
 None
 0.83A 5cg5A-2azkA:
22.5		 5cg5A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		6 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.86A 5cg5A-2azkA:
22.5		 5cg5A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		9 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
 0.59A 5cg5A-2dh4A:
26.6		 5cg5A-2dh4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.82A 5cg5A-2ftzA:
24.5		 5cg5A-2ftzA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.50A 5cg5A-2ftzA:
24.5		 5cg5A-2ftzA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.37A 5cg5A-2o1oA:
36.1		 5cg5A-2o1oA:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
 MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
 0.88A 5cg5A-2q80A:
12.9		 5cg5A-2q80A:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		6 LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
 None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
 1.15A 5cg5A-2q80A:
12.9		 5cg5A-2q80A:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		8 LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
 None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
 0.64A 5cg5A-2q80A:
12.9		 5cg5A-2q80A:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		6 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.67A 5cg5A-3aq0A:
25.2		 5cg5A-3aq0A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		7 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.02A 5cg5A-3aqcB:
28.0		 5cg5A-3aqcB:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		7 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.83A 5cg5A-3aqcB:
28.0		 5cg5A-3aqcB:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		5 LEU A  91
ASP A 100
ARG A 105
GLN A 168
THR A 193
 None
 0.96A 5cg5A-3lomA:
25.6		 5cg5A-3lomA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		5 LEU A  91
ASP A 100
GLN A 168
THR A 193
GLN A 231
 None
 1.08A 5cg5A-3lomA:
25.6		 5cg5A-3lomA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		6 LEU A  78
ASP A  87
ARG A  92
GLN A 153
LYS A 178
THR A 179
 None
 0.89A 5cg5A-3m0gA:
24.4		 5cg5A-3m0gA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 LEU A  86
ARG A 100
THR A 184
GLN A 221
ASP A 224
 GOL  A 310 ( 4.3A)
None
None
None
None
 0.90A 5cg5A-3m9uA:
25.1		 5cg5A-3m9uA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		6 LEU A  90
ASP A  93
ARG A 102
LYS A 179
THR A 180
GLN A 217
 None
 0.82A 5cg5A-3mzvA:
25.9		 5cg5A-3mzvA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		6 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
 None
 1.28A 5cg5A-3npkA:
25.6		 5cg5A-3npkA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		6 LEU A  75
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 None
 0.92A 5cg5A-3npkA:
25.6		 5cg5A-3npkA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 LEU A  80
ARG A  94
LYS A 180
THR A 181
GLN A 219
 None
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
 0.98A 5cg5A-3p41A:
23.4		 5cg5A-3p41A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		7 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.47A 5cg5A-3p41A:
23.4		 5cg5A-3p41A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  82
ARG A  93
GLN A 153
THR A 177
 None
 1.21A 5cg5A-3p8lA:
25.0		 5cg5A-3p8lA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  88
ARG A  93
GLN A 153
THR A 177
 None
 0.73A 5cg5A-3p8lA:
25.0		 5cg5A-3p8lA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
 None
None
CIT  A 326 ( 4.8A)
None
None
 0.90A 5cg5A-3pkoA:
25.2		 5cg5A-3pkoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
 None
None
CIT  A 326 ( 4.8A)
None
None
 0.90A 5cg5A-3pkoA:
25.2		 5cg5A-3pkoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 ASP A  98
ARG A 103
GLN A 225
ASP A 228
LYS A 242
 MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
DMA  A 501 (-2.7A)
 1.19A 5cg5A-3q1oA:
30.8		 5cg5A-3q1oA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		10 LEU A  89
ASP A  92
ASP A  98
ARG A 103
GLN A 163
LYS A 186
THR A 187
GLN A 225
ASP A 228
LYS A 242
 DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.6A)
DMA  A 501 (-3.1A)
DMA  A 500 (-3.4A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
DMA  A 501 (-2.7A)
 0.48A 5cg5A-3q1oA:
30.8		 5cg5A-3q1oA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		6 LEU A 105
ARG A 117
LYS A 215
THR A 216
GLN A 254
LYS A 271
 None
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 ( 4.0A)
DMA  A 383 (-3.2A)
DMA  A 384 ( 2.8A)
 1.17A 5cg5A-3qqvA:
33.0		 5cg5A-3qqvA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		7 LEU A 105
ASP A 108
ASP A 112
ARG A 117
GLN A 191
LYS A 215
TYR A 219
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
DMA  A 384 (-3.0A)
DMA  A 384 ( 4.9A)
 0.93A 5cg5A-3qqvA:
33.0		 5cg5A-3qqvA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		7 LEU A 105
ASP A 108
ASP A 112
ARG A 117
LYS A 215
THR A 216
GLN A 254
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 ( 4.0A)
DMA  A 383 (-3.2A)
 0.58A 5cg5A-3qqvA:
33.0		 5cg5A-3qqvA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 LEU A  74
ASP A  77
LYS A 162
THR A 163
GLN A 197
 None
 0.74A 5cg5A-3tc1A:
25.4		 5cg5A-3tc1A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 LEU A  74
LYS A 162
THR A 163
GLN A 197
ASP A 200
 None
None
None
None
MG  A 500 (-2.9A)
 0.47A 5cg5A-3tc1A:
25.4		 5cg5A-3tc1A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		6 LEU A  85
ASP A  88
ASP A  94
ARG A  99
GLN A 162
THR A 186
 None
 1.21A 5cg5A-3ts7A:
24.1		 5cg5A-3ts7A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		6 LEU A  85
ASP A  88
ASP A  94
ARG A  99
LYS A 185
THR A 186
 None
 1.02A 5cg5A-3ts7A:
24.1		 5cg5A-3ts7A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		6 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.94A 5cg5A-3wjoA:
25.1		 5cg5A-3wjoA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		6 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.88A 5cg5A-3wjoA:
25.1		 5cg5A-3wjoA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		6 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.89A 5cg5A-3wjoA:
25.1		 5cg5A-3wjoA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		6 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.67A 5cg5A-3zouA:
23.0		 5cg5A-3zouA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		6 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.51A 5cg5A-3zouA:
23.0		 5cg5A-3zouA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		5 LEU A  80
ASP A  83
ASP A  89
ARG A  94
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
None
 1.22A 5cg5A-3zouA:
23.0		 5cg5A-3zouA:
28.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.42A 5cg5A-4e1eA:
44.4		 5cg5A-4e1eA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		5 LEU A  80
ASP A  83
ASP A  89
LYS A 178
THR A 179
 None
 0.81A 5cg5A-4f62A:
23.4		 5cg5A-4f62A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		5 LEU A  80
ASP A  83
GLN A 155
LYS A 178
THR A 179
 None
 1.01A 5cg5A-4f62A:
23.4		 5cg5A-4f62A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		6 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
 1.04A 5cg5A-4fp4A:
20.6		 5cg5A-4fp4A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		6 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
 1.12A 5cg5A-4fp4A:
20.6		 5cg5A-4fp4A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		6 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.03A 5cg5A-4fp4A:
20.6		 5cg5A-4fp4A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
 None
 0.87A 5cg5A-4gp1A:
27.6		 5cg5A-4gp1A:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.86A 5cg5A-4gp1A:
27.6		 5cg5A-4gp1A:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE

(Pseudoalteromonas
atlantica) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.93A 5cg5A-4jxyA:
25.2		 5cg5A-4jxyA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE

(Pseudoalteromonas
atlantica) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.86A 5cg5A-4jxyA:
25.2		 5cg5A-4jxyA:
25.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		5 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.18A 5cg5A-4jzxA:
44.4		 5cg5A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.66A 5cg5A-4jzxA:
44.4		 5cg5A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.43A 5cg5A-4jzxA:
44.4		 5cg5A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		6 LEU A  94
ASP A  97
ARG A 106
THR A 161
GLN A 165
THR A 195
 None
 0.80A 5cg5A-4kk2A:
40.3		 5cg5A-4kk2A:
44.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		7 LEU A  94
ASP A  97
ARG A 106
THR A 161
LYS A 194
THR A 195
TYR A 198
 None
 0.86A 5cg5A-4kk2A:
40.3		 5cg5A-4kk2A:
44.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		5 LEU A  94
THR A 161
THR A 195
TYR A 198
GLN A 233
 None
 0.81A 5cg5A-4kk2A:
40.3		 5cg5A-4kk2A:
44.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		6 LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 159
THR A 185
 None
 0.65A 5cg5A-4kkmA:
25.5		 5cg5A-4kkmA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		5 LEU A  83
ASP A  92
ARG A  97
LYS A 184
THR A 185
 None
 1.11A 5cg5A-4kkmA:
25.5		 5cg5A-4kkmA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		7 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.91A 5cg5A-4lfeA:
25.4		 5cg5A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		7 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.69A 5cg5A-4lfeA:
25.4		 5cg5A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		7 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.49A 5cg5A-4lfeA:
25.4		 5cg5A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		7 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 5cg5A-4llsA:
28.5		 5cg5A-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.67A 5cg5A-4llsA:
28.5		 5cg5A-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE

(Acinetobacter
baumannii) 		PF00348
(polyprenyl_synt) 		5 LEU A  85
ASP A  88
LYS A 174
THR A 175
GLN A 211
 None
 0.87A 5cg5A-4lobA:
27.0		 5cg5A-4lobA:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE

(Acinetobacter
baumannii) 		PF00348
(polyprenyl_synt) 		5 LEU A  85
LYS A 174
THR A 175
GLN A 211
ASP A 214
 None
 0.86A 5cg5A-4lobA:
27.0		 5cg5A-4lobA:
27.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		12 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
GLN A 171
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
 0.23A 5cg5A-4p0vA:
53.8		 5cg5A-4p0vA:
99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		10 ASP A 103
ASP A 107
ARG A 112
THR A 168
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
 0.25A 5cg5A-4rxeA:
43.5		 5cg5A-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		10 ASP A 103
ASP A 107
THR A 168
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
LYS A 269
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.57A 5cg5A-4rxeA:
43.5		 5cg5A-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		9 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
GLN A 172
LYS A 212
TYR A 216
ASP A 255
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.7A)
MG  A3003 ( 2.9A)
 0.49A 5cg5A-4rxeA:
43.5		 5cg5A-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		9 LEU A 100
ASP A 103
ASP A 107
THR A 168
GLN A 172
LYS A 212
TYR A 216
ASP A 255
LYS A 269
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.7A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
 0.73A 5cg5A-4rxeA:
43.5		 5cg5A-4rxeA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		6 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
 None
 0.74A 5cg5A-4wk5A:
23.9		 5cg5A-4wk5A:
25.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		5 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
 MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 1.21A 5cg5A-5ahuB:
16.7		 5cg5A-5ahuB:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		12 LEU B 100
ASP B 103
ASP B 107
ARG B 112
THR B 168
GLN B 172
LYS B 212
THR B 213
TYR B 216
GLN B 252
ASP B 255
LYS B 269
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
None
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
 0.47A 5cg5A-5ahuB:
16.7		 5cg5A-5ahuB:
33.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		7 LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 160
LYS A 183
THR A 184
 None
 0.85A 5cg5A-5aypA:
23.6		 5cg5A-5aypA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A  88
ASP A  91
ASP A  97
ARG A 102
GLN A 166
 None
 0.97A 5cg5A-5e8lA:
23.4		 5cg5A-5e8lA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		6 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
 0.97A 5cg5A-5h9dA:
28.0		 5cg5A-5h9dA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.83A 5cg5A-5h9dA:
28.0		 5cg5A-5h9dA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
 PO4  A 501 (-4.5A)
None
None
None
None
 0.96A 5cg5A-5h9dA:
28.0		 5cg5A-5h9dA:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		11 ASP A 126
ASP A 130
ARG A 135
THR A 191
GLN A 195
LYS A 243
THR A 244
TYR A 247
GLN A 284
ASP A 287
LYS A 301
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-4.8A)
04M  A 401 (-3.3A)
04M  A 401 (-4.5A)
04M  A 401 ( 3.8A)
04M  A 401 (-4.5A)
None
None
04M  A 401 ( 3.9A)
 0.66A 5cg5A-5hn7A:
43.4		 5cg5A-5hn7A:
34.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		5 LEU A  82
ASP A  85
ASP A  91
THR A 191
GLN A 228
 None
 1.03A 5cg5A-5xn6A:
23.5		 5cg5A-5xn6A:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 11 ASP A 147
ASP A 151
ARG A 156
THR A 211
GLN A 215
LYS A 244
THR A 245
TYR A 248
GLN A 284
ASP A 287
LYS A 301
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
None
C6M  A 401 (-3.3A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.6A)
None
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
C6M  A 401 (-2.9A)
 0.25A 5cg5A-6b07A:
45.9		 5cg5A-6b07A:
14.39