SIMILAR PATTERNS OF AMINO ACIDS FOR 5CDQ_W_MFXW2101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 ARG A 192
SER A 195
ASP A 106
GLU A  57
 None
 1.00A 5cdqR-1uz4A:
0.0
5cdqT-1uz4A:
0.0
5cdqU-1uz4A:
1.6		 5cdqR-1uz4A:
19.42
5cdqT-1uz4A:
19.42
5cdqU-1uz4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		4 ARG A  27
SER A 237
ASP A  24
GLU A 385
 None
 1.33A 5cdqR-1x1nA:
0.0
5cdqT-1x1nA:
0.0
5cdqU-1x1nA:
1.0		 5cdqR-1x1nA:
23.56
5cdqT-1x1nA:
23.56
5cdqU-1x1nA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afd N-ACETYLNEURAMINATE
LYASE

(Aliivibrio
salmonicida) 		PF00701
(DHDPS) 		4 ARG A 272
SER A  54
ASP A  16
GLU A  24
 GOL  A1301 ( 4.8A)
None
None
None
 1.07A 5cdqR-5afdA:
0.3
5cdqT-5afdA:
0.0
5cdqU-5afdA:
0.0		 5cdqR-5afdA:
20.54
5cdqT-5afdA:
20.54
5cdqU-5afdA:
20.60