SIMILAR PATTERNS OF AMINO ACIDS FOR 5CDN_O_EVPO2101_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 GLU A 155
ASP A 146
ARG A 267
GLY A 268
 FAD  A 600 (-2.7A)
None
None
None
 0.92A 5cdnC-1d4eA:
undetectable
5cdnD-1d4eA:
undetectable		 5cdnC-1d4eA:
21.36
5cdnD-1d4eA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io1 PHASE 1 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		4 GLU A 290
GLY A 328
ASP A 330
GLY A 302
 None
 0.92A 5cdnC-1io1A:
undetectable
5cdnD-1io1A:
undetectable		 5cdnC-1io1A:
21.50
5cdnD-1io1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		4 GLU A 154
GLY A 333
ASP A 332
GLY A 105
 EDO  A 502 (-2.9A)
None
None
None
 0.84A 5cdnC-1n0wA:
undetectable
5cdnD-1n0wA:
undetectable		 5cdnC-1n0wA:
19.63
5cdnD-1n0wA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		4 SER A 128
GLU A 202
ASP A  47
GLY A  42
 None
None
None
PO4  A 900 (-3.8A)
 0.92A 5cdnC-1nrwA:
1.6
5cdnD-1nrwA:
undetectable		 5cdnC-1nrwA:
22.11
5cdnD-1nrwA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 GLU A 131
GLY A 224
ARG A 222
GLY A 170
 None
None
FMN  A1730 (-2.8A)
None
 0.76A 5cdnC-1o94A:
0.0
5cdnD-1o94A:
undetectable		 5cdnC-1o94A:
22.83
5cdnD-1o94A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 SER A 881
GLU A 883
GLY A1064
GLY A1128
 None
None
FMN  A2508 (-3.6A)
FMN  A2508 (-3.4A)
 0.91A 5cdnC-1ofeA:
0.0
5cdnD-1ofeA:
undetectable		 5cdnC-1ofeA:
16.24
5cdnD-1ofeA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Bacillus
subtilis) 		PF01070
(FMN_dh) 		4 SER A 247
GLU A 248
GLY A  24
ASP A  27
 None
 0.85A 5cdnC-1p0nA:
undetectable
5cdnD-1p0nA:
undetectable		 5cdnC-1p0nA:
22.55
5cdnD-1p0nA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q56 AGRIN

(Gallus gallus) 		PF00054
(Laminin_G_1) 		4 SER A  40
GLY A  85
ASP A  83
GLY A 131
 None
 0.94A 5cdnC-1q56A:
undetectable
5cdnD-1q56A:
undetectable		 5cdnC-1q56A:
16.94
5cdnD-1q56A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE

(Escherichia
coli) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		4 GLY A  24
ASP A  20
ARG A  25
GLY A  41
 None
 0.91A 5cdnC-1sfeA:
0.0
5cdnD-1sfeA:
undetectable		 5cdnC-1sfeA:
18.71
5cdnD-1sfeA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 GLU A 274
GLY A 133
ASP A 232
GLY A 289
 None
 0.91A 5cdnC-1u6rA:
undetectable
5cdnD-1u6rA:
undetectable		 5cdnC-1u6rA:
22.73
5cdnD-1u6rA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulr PUTATIVE
ACYLPHOSPHATASE

(Thermus
thermophilus) 		PF00708
(Acylphosphatase) 		4 GLY A  40
ASP A  39
ARG A  41
GLY A  10
 None
 0.95A 5cdnC-1ulrA:
2.9
5cdnD-1ulrA:
undetectable		 5cdnC-1ulrA:
12.06
5cdnD-1ulrA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uou THYMIDINE
PHOSPHORYLASE

(Homo sapiens) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 SER A 169
GLU A 171
GLY A 163
GLY A 351
 None
 0.94A 5cdnC-1uouA:
2.3
5cdnD-1uouA:
3.0		 5cdnC-1uouA:
21.88
5cdnD-1uouA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		4 GLU A 366
GLY A 147
ASP A  21
GLY A 376
 None
3PG  A 401 (-4.7A)
3PG  A 401 (-2.9A)
ANP  A 400 (-3.5A)
 0.80A 5cdnC-1vpeA:
undetectable
5cdnD-1vpeA:
undetectable		 5cdnC-1vpeA:
23.51
5cdnD-1vpeA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 GLU A 249
GLY A 117
ASP A 150
GLY A 140
 None
None
MPD  A3003 (-4.3A)
None
 0.93A 5cdnC-1wz8A:
undetectable
5cdnD-1wz8A:
undetectable		 5cdnC-1wz8A:
22.66
5cdnD-1wz8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi9 PUTATIVE
TRANSAMINASE

(Pyrococcus
furiosus) 		PF00155
(Aminotran_1_2) 		4 GLU A 314
ASP A 347
ARG A 395
GLY A 336
 None
 0.81A 5cdnC-1xi9A:
undetectable
5cdnD-1xi9A:
undetectable		 5cdnC-1xi9A:
23.72
5cdnD-1xi9A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2

(Homo sapiens) 		PF01583
(APS_kinase) 		4 GLU A 147
GLY A  41
ARG A  51
GLY A 124
 None
 0.59A 5cdnC-2ax4A:
undetectable
5cdnD-2ax4A:
undetectable		 5cdnC-2ax4A:
15.18
5cdnD-2ax4A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE

(Anopheles
gambiae) 		PF00266
(Aminotran_5) 		4 GLU A 123
GLY A 319
ARG A 356
GLY A 157
 None
None
GOL  A1391 (-3.1A)
None
 0.87A 5cdnC-2ch1A:
undetectable
5cdnD-2ch1A:
undetectable		 5cdnC-2ch1A:
21.41
5cdnD-2ch1A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 GLY A 342
ASP A 325
ARG A 343
GLY A 346
 None
 0.87A 5cdnC-2douA:
undetectable
5cdnD-2douA:
undetectable		 5cdnC-2douA:
22.65
5cdnD-2douA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		4 GLU A 462
ASP A 408
ARG A 410
GLY A 411
 None
 0.89A 5cdnC-2e3zA:
undetectable
5cdnD-2e3zA:
undetectable		 5cdnC-2e3zA:
22.30
5cdnD-2e3zA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		4 SER A 489
GLU A 487
GLY A 469
ASP A 458
 None
 0.93A 5cdnC-2ffuA:
undetectable
5cdnD-2ffuA:
undetectable		 5cdnC-2ffuA:
22.24
5cdnD-2ffuA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fo5 CYSTEINE PROTEINASE
EP-B 2

(Hordeum vulgare) 		PF00112
(Peptidase_C1) 		4 SER A  52
GLY A  69
ASP A  65
GLY A  26
 None
 0.88A 5cdnC-2fo5A:
undetectable
5cdnD-2fo5A:
undetectable		 5cdnC-2fo5A:
20.08
5cdnD-2fo5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd9 HYPOTHETICAL PROTEIN
YYAP

(Bacillus
subtilis) 		PF01872
(RibD_C) 		4 GLU A 108
GLY A 126
ARG A  90
GLY A  53
 None
CL  A 189 (-3.9A)
PO4  A 190 ( 3.8A)
CL  A 189 (-3.4A)
 0.91A 5cdnC-2gd9A:
undetectable
5cdnD-2gd9A:
2.2		 5cdnC-2gd9A:
17.30
5cdnD-2gd9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf1 INSULIN-LIKE GROWTH
FACTOR I

(Homo sapiens) 		PF00049
(Insulin) 		4 GLU A   9
GLY A  22
ARG A  21
GLY A  19
 None
 0.61A 5cdnC-2gf1A:
undetectable
5cdnD-2gf1A:
undetectable		 5cdnC-2gf1A:
9.44
5cdnD-2gf1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 SER A 287
GLY A 251
ASP A 256
GLY A 247
 None
 0.93A 5cdnC-2j3zA:
undetectable
5cdnD-2j3zA:
undetectable		 5cdnC-2j3zA:
21.70
5cdnD-2j3zA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		4 GLU A 201
ASP A 295
ARG A 267
GLY A 196
 None
 0.95A 5cdnC-2o7rA:
undetectable
5cdnD-2o7rA:
3.5		 5cdnC-2o7rA:
21.30
5cdnD-2o7rA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 GLU A  41
GLY A  25
ASP A  24
GLY A  50
 None
 0.95A 5cdnC-2ph3A:
undetectable
5cdnD-2ph3A:
2.5		 5cdnC-2ph3A:
21.67
5cdnD-2ph3A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2por PORIN

(Rhodobacter
capsulatus) 		PF13609
(Porin_4) 		4 SER A  32
GLU A   1
GLY A  73
GLY A  59
 None
 0.86A 5cdnC-2porA:
undetectable
5cdnD-2porA:
undetectable		 5cdnC-2porA:
20.30
5cdnD-2porA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2i SECRETION CHAPERONE

(Agrobacterium
fabrum) 		PF01588
(tRNA_bind) 		4 SER A  83
GLY A  41
ARG A  16
GLY A  18
 None
 0.87A 5cdnC-2q2iA:
undetectable
5cdnD-2q2iA:
undetectable		 5cdnC-2q2iA:
14.96
5cdnD-2q2iA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		4 GLU A 217
ASP A 422
ARG A 398
GLY A 399
 None
 0.76A 5cdnC-2qzpA:
undetectable
5cdnD-2qzpA:
3.6		 5cdnC-2qzpA:
23.19
5cdnD-2qzpA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vml PHYCOCYANIN ALPHA
CHAIN

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		4 SER A  11
GLY A 103
ASP A 106
GLY A 101
 None
 0.85A 5cdnC-2vmlA:
2.5
5cdnD-2vmlA:
undetectable		 5cdnC-2vmlA:
16.22
5cdnD-2vmlA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgh GRANZYME M

(Homo sapiens) 		PF00089
(Trypsin) 		4 SER A  61
GLY A 126
ARG A 139
GLY A 124
 None
None
SO4  A 241 (-3.9A)
None
 0.92A 5cdnC-2zghA:
undetectable
5cdnD-2zghA:
undetectable		 5cdnC-2zghA:
17.49
5cdnD-2zghA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 SER A 778
GLY A 734
ASP A 784
GLY A 713
 None
 0.94A 5cdnC-3ak5A:
undetectable
5cdnD-3ak5A:
undetectable		 5cdnC-3ak5A:
19.77
5cdnD-3ak5A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1d REGULATORY PROTEIN
RECX

(Escherichia
coli) 		PF02631
(RecX) 		4 SER A 102
GLU A 104
ASP A  26
ARG A  77
 None
 0.84A 5cdnC-3c1dA:
undetectable
5cdnD-3c1dA:
undetectable		 5cdnC-3c1dA:
16.11
5cdnD-3c1dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e18 OXIDOREDUCTASE

(Listeria
innocua) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 SER A 100
GLU A 101
GLY A 170
ASP A 207
GLY A 168
 None
 1.39A 5cdnC-3e18A:
undetectable
5cdnD-3e18A:
undetectable		 5cdnC-3e18A:
21.46
5cdnD-3e18A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens) 		PF00626
(Gelsolin) 		4 SER A 537
GLU A 606
ASP A 529
GLY A 709
 None
 0.90A 5cdnC-3fg6A:
undetectable
5cdnD-3fg6A:
undetectable		 5cdnC-3fg6A:
21.98
5cdnD-3fg6A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gla LOW MOLECULAR WEIGHT
HEAT SHOCK PROTEIN

(Xanthomonas
citri) 		PF00011
(HSP20) 		4 GLU A  51
GLY A 127
ARG A 125
GLY A 124
 PO4  A   1 ( 4.8A)
None
None
None
 0.87A 5cdnC-3glaA:
undetectable
5cdnD-3glaA:
undetectable		 5cdnC-3glaA:
12.64
5cdnD-3glaA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3god CAS1

(Pseudomonas
aeruginosa) 		PF01867
(Cas_Cas1) 		4 GLU A 189
GLY A 261
ARG A 258
GLY A 255
 None
 0.78A 5cdnC-3godA:
undetectable
5cdnD-3godA:
undetectable		 5cdnC-3godA:
21.77
5cdnD-3godA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		4 GLU A  75
GLY A 306
ASP A 307
GLY A  12
 PO4  A2001 (-2.5A)
FAD  A1001 (-3.2A)
FAD  A1001 (-3.2A)
FAD  A1001 (-3.8A)
 0.77A 5cdnC-3h8lA:
undetectable
5cdnD-3h8lA:
undetectable		 5cdnC-3h8lA:
21.57
5cdnD-3h8lA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 GLY B 363
ASP B 364
ARG B 359
GLY B 360
 None
 0.95A 5cdnC-3hhsB:
undetectable
5cdnD-3hhsB:
undetectable		 5cdnC-3hhsB:
20.69
5cdnD-3hhsB:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 GLU A 245
GLY A 202
ARG A 203
GLY A 206
 None
None
NAD  A 501 (-4.8A)
NAD  A 501 ( 4.4A)
 0.77A 5cdnC-3ju8A:
undetectable
5cdnD-3ju8A:
undetectable		 5cdnC-3ju8A:
21.61
5cdnD-3ju8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 SER A 153
GLU A  82
GLY A  15
GLY A 120
 None
 0.92A 5cdnC-3k17A:
2.4
5cdnD-3k17A:
undetectable		 5cdnC-3k17A:
22.36
5cdnD-3k17A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3od1 ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Bacillus
halodurans) 		PF13393
(tRNA-synt_His) 		4 SER A 259
GLU A 254
GLY A 284
GLY A 282
 None
 0.90A 5cdnC-3od1A:
undetectable
5cdnD-3od1A:
undetectable		 5cdnC-3od1A:
23.40
5cdnD-3od1A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 SER B 140
GLY B 338
ASP B 339
GLY B 287
 SRM  B 581 (-2.7A)
None
None
None
 0.94A 5cdnC-3or2B:
2.8
5cdnD-3or2B:
undetectable		 5cdnC-3or2B:
19.77
5cdnD-3or2B:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLU A 295
GLY A 150
ASP A 153
GLY A 271
 None
 0.89A 5cdnC-3tl2A:
undetectable
5cdnD-3tl2A:
undetectable		 5cdnC-3tl2A:
22.86
5cdnD-3tl2A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		4 SER A 203
GLY A 258
ASP A 259
GLY A 254
 None
 0.93A 5cdnC-3vpzA:
undetectable
5cdnD-3vpzA:
undetectable		 5cdnC-3vpzA:
21.53
5cdnD-3vpzA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Bos taurus) 		PF00118
(Cpn60_TCP1) 		4 GLU A 337
GLY A 364
ASP A 198
GLY A 193
 None
 0.93A 5cdnC-4a0wA:
undetectable
5cdnD-4a0wA:
undetectable		 5cdnC-4a0wA:
24.09
5cdnD-4a0wA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		4 SER A 259
ASP A 240
ARG A 242
GLY A 252
 None
 0.94A 5cdnC-4ag4A:
undetectable
5cdnD-4ag4A:
undetectable		 5cdnC-4ag4A:
21.07
5cdnD-4ag4A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 GLU A 414
GLY A 601
ARG A 598
GLY A 597
 None
None
SO4  A1724 (-2.5A)
None
 0.94A 5cdnC-4b3iA:
undetectable
5cdnD-4b3iA:
undetectable		 5cdnC-4b3iA:
21.63
5cdnD-4b3iA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 GLU A 550
GLY A 201
ASP A 200
GLY A 407
 None
None
ZN  A1002 ( 2.1A)
None
 0.90A 5cdnC-4b56A:
3.0
5cdnD-4b56A:
undetectable		 5cdnC-4b56A:
19.40
5cdnD-4b56A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhl ARGININE KINASE

(Litopenaeus
vannamei) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 SER A 174
GLU A 176
GLY A 207
GLY A 209
 None
 0.72A 5cdnC-4bhlA:
1.4
5cdnD-4bhlA:
undetectable		 5cdnC-4bhlA:
21.48
5cdnD-4bhlA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 SER A 733
GLY A 370
ASP A 369
GLY A 300
 None
 0.93A 5cdnC-4cakA:
undetectable
5cdnD-4cakA:
undetectable		 5cdnC-4cakA:
19.29
5cdnD-4cakA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecd CHORISMATE SYNTHASE

(Bifidobacterium
longum) 		PF01264
(Chorismate_synt) 		4 SER A 192
GLY A  47
ASP A 344
ARG A  46
 None
 0.93A 5cdnC-4ecdA:
2.1
5cdnD-4ecdA:
undetectable		 5cdnC-4ecdA:
23.26
5cdnD-4ecdA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 GLU A 126
GLY A 382
ASP A 383
GLY A  64
 GLU  A 126 ( 0.5A)
GLY  A 382 (-0.0A)
ASP  A 383 (-0.5A)
GLY  A  64 (-0.0A)
 0.74A 5cdnC-4g9kA:
undetectable
5cdnD-4g9kA:
undetectable		 5cdnC-4g9kA:
22.75
5cdnD-4g9kA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 SER A 242
GLY A 207
ARG A 229
GLY A 228
 None
 0.93A 5cdnC-4gpgA:
undetectable
5cdnD-4gpgA:
undetectable		 5cdnC-4gpgA:
19.13
5cdnD-4gpgA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		4 SER A1079
GLY A 434
ASP A 435
GLY A 457
 None
 0.68A 5cdnC-4i3hA:
55.6
5cdnD-4i3hA:
22.1		 5cdnC-4i3hA:
20.56
5cdnD-4i3hA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6o METALLOPHOSPHOESTERA
SE

(Ruminiclostridium
thermocellum) 		PF00149
(Metallophos) 		4 GLU A 340
GLY A 186
ASP A 392
GLY A 232
 None
None
MN  A 508 ( 4.7A)
None
 0.86A 5cdnC-4j6oA:
undetectable
5cdnD-4j6oA:
undetectable		 5cdnC-4j6oA:
19.63
5cdnD-4j6oA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8b COATOMER ALPHA
SUBUNIT

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 GLY A  72
ASP A  73
ARG A  57
GLY A  58
 None
 0.67A 5cdnC-4j8bA:
undetectable
5cdnD-4j8bA:
undetectable		 5cdnC-4j8bA:
18.88
5cdnD-4j8bA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli) 		PF16168
(AIDA) 		4 SER A  43
GLU A  45
GLY A 103
GLY A  87
 None
 0.94A 5cdnC-4kh3A:
undetectable
5cdnD-4kh3A:
undetectable		 5cdnC-4kh3A:
22.18
5cdnD-4kh3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 4 SER A 256
GLU A 257
GLY A  34
GLY A  32
 None
 0.79A 5cdnC-4l9aA:
undetectable
5cdnD-4l9aA:
4.0		 5cdnC-4l9aA:
20.70
5cdnD-4l9aA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		4 GLU A 226
GLY A 234
ASP A 283
GLY A 155
 None
 0.58A 5cdnC-4mcoA:
undetectable
5cdnD-4mcoA:
undetectable		 5cdnC-4mcoA:
20.73
5cdnD-4mcoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn3 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		4 GLU A  30
ASP A 239
ARG A  43
GLY A  46
 None
None
ORO  A 403 (-2.9A)
None
 0.88A 5cdnC-4nn3A:
undetectable
5cdnD-4nn3A:
undetectable		 5cdnC-4nn3A:
21.84
5cdnD-4nn3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqz ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		4 GLU A  74
GLY A 142
ASP A  88
ARG A 140
 None
 0.87A 5cdnC-4nqzA:
undetectable
5cdnD-4nqzA:
3.1		 5cdnC-4nqzA:
19.17
5cdnD-4nqzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2) 		4 GLY A  92
ASP A  93
ARG A 114
GLY A 116
 None
 0.88A 5cdnC-4nzjA:
undetectable
5cdnD-4nzjA:
undetectable		 5cdnC-4nzjA:
20.08
5cdnD-4nzjA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbc D-AMINO ACID
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01063
(Aminotran_4) 		4 SER A  21
GLU A  26
ASP A  47
ARG A 120
 None
 0.83A 5cdnC-4pbcA:
undetectable
5cdnD-4pbcA:
undetectable		 5cdnC-4pbcA:
22.20
5cdnD-4pbcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLU A 288
ASP A 240
ARG A 219
GLY A 218
 None
 0.68A 5cdnC-4pwnA:
2.9
5cdnD-4pwnA:
undetectable		 5cdnC-4pwnA:
20.50
5cdnD-4pwnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		4 GLU A 352
ASP A 334
ARG A  45
GLY A 112
 None
 0.86A 5cdnC-4pxlA:
undetectable
5cdnD-4pxlA:
undetectable		 5cdnC-4pxlA:
20.64
5cdnD-4pxlA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmx PHI92_GP150

(Enterobacteria
phage phi92) 		no annotation 4 GLY A 658
ASP A 657
ARG A 662
GLY A 660
 None
 0.88A 5cdnC-4rmxA:
undetectable
5cdnD-4rmxA:
undetectable		 5cdnC-4rmxA:
20.72
5cdnD-4rmxA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tm5 D-AMINO ACID
AMINOTRANSFERASE

(Burkholderia
thailandensis) 		PF01063
(Aminotran_4) 		4 SER A  13
GLU A  18
ASP A  39
ARG A 113
 None
 0.80A 5cdnC-4tm5A:
undetectable
5cdnD-4tm5A:
undetectable		 5cdnC-4tm5A:
20.20
5cdnD-4tm5A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 SER A 412
GLY A 254
ASP A 255
GLY A 419
 None
 0.82A 5cdnC-4tweA:
undetectable
5cdnD-4tweA:
undetectable		 5cdnC-4tweA:
21.83
5cdnD-4tweA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		4 SER A 103
GLY A  92
ASP A  93
ARG A  35
 None
 0.77A 5cdnC-4ypvA:
undetectable
5cdnD-4ypvA:
3.7		 5cdnC-4ypvA:
23.12
5cdnD-4ypvA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG

(Bacillus
subtilis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 SER A 332
GLY A 337
ASP A 187
GLY A 322
 None
 0.88A 5cdnC-4yxtA:
undetectable
5cdnD-4yxtA:
undetectable		 5cdnC-4yxtA:
24.00
5cdnD-4yxtA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7l CAS6B

(Methanococcus
maripaludis) 		PF17262
(DUF5328) 		4 GLU A 175
GLY A  20
ARG A 210
GLY A 211
 None
None
SO4  A 301 (-3.3A)
None
 0.86A 5cdnC-4z7lA:
2.2
5cdnD-4z7lA:
undetectable		 5cdnC-4z7lA:
19.45
5cdnD-4z7lA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 272
GLU A 270
GLY A 131
ASP A 132
 None
 0.77A 5cdnC-5by7A:
undetectable
5cdnD-5by7A:
undetectable		 5cdnC-5by7A:
20.64
5cdnD-5by7A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 GLU A  42
GLY A 154
ARG A 101
GLY A 100
 None
 0.80A 5cdnC-5bzaA:
undetectable
5cdnD-5bzaA:
undetectable		 5cdnC-5bzaA:
21.64
5cdnD-5bzaA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdo DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B

(Staphylococcus
aureus) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 GLY B 436
ASP B 437
ARG B 458
GLY B 459
 None
 0.73A 5cdnC-5cdoB:
undetectable
5cdnD-5cdoB:
32.6		 5cdnC-5cdoB:
18.03
5cdnD-5cdoB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 SER A 765
GLY A  80
ASP A  82
GLY A  77
 None
None
NA  A1015 ( 4.9A)
SF4  A1001 ( 3.7A)
 0.95A 5cdnC-5chcA:
undetectable
5cdnD-5chcA:
1.9		 5cdnC-5chcA:
19.12
5cdnD-5chcA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eeb ALDEHYDE
DEHYDROGENASE

(Pyrobaculum
ferrireducens) 		PF00171
(Aldedh) 		4 SER A 159
GLU A 106
GLY A 458
GLY A 450
 None
 0.89A 5cdnC-5eebA:
undetectable
5cdnD-5eebA:
undetectable		 5cdnC-5eebA:
22.50
5cdnD-5eebA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwn PROTEIN RCC2

(Homo sapiens) 		PF00415
(RCC1) 		4 GLU A 264
GLY A 185
ASP A 186
GLY A 183
 None
None
SO4  A 603 (-4.4A)
None
 0.82A 5cdnC-5gwnA:
undetectable
5cdnD-5gwnA:
undetectable		 5cdnC-5gwnA:
22.07
5cdnD-5gwnA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 GLU A 495
GLY A 148
ASP A 147
GLY A 354
 None
ZN  A 902 ( 4.9A)
ZN  A 902 (-1.8A)
None
 0.89A 5cdnC-5gz4A:
2.6
5cdnD-5gz4A:
undetectable		 5cdnC-5gz4A:
21.20
5cdnD-5gz4A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 GLY A 793
ASP A 794
ARG A 788
GLY A 791
 None
 0.91A 5cdnC-5hm5A:
2.3
5cdnD-5hm5A:
undetectable		 5cdnC-5hm5A:
22.07
5cdnD-5hm5A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iaa UBIQUITIN-FOLD
MODIFIER 1
UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5

(Homo sapiens) 		PF00899
(ThiF)
PF03671
(Ufm1) 		4 GLU A 132
GLY C  83
ASP A 183
GLY A  83
 None
 0.86A 5cdnC-5iaaA:
undetectable
5cdnD-5iaaA:
3.7		 5cdnC-5iaaA:
21.38
5cdnD-5iaaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		4 SER A 246
GLU A 248
GLY A 175
GLY A 254
 None
 0.67A 5cdnC-5jc8A:
undetectable
5cdnD-5jc8A:
3.0		 5cdnC-5jc8A:
20.91
5cdnD-5jc8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo9 RIBITOL
2-DEHYDROGENASE

(Bradyrhizobium
japonicum) 		PF00106
(adh_short) 		4 GLY A 133
ASP A 134
ARG A 177
GLY A 175
 None
 0.95A 5cdnC-5jo9A:
undetectable
5cdnD-5jo9A:
3.1		 5cdnC-5jo9A:
19.96
5cdnD-5jo9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		4 GLU A 214
ASP A 166
ARG A 145
GLY A 144
 None
 0.80A 5cdnC-5o2cA:
3.7
5cdnD-5o2cA:
undetectable		 5cdnC-5o2cA:
19.46
5cdnD-5o2cA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2q BREAST CANCER
ANTI-ESTROGEN
RESISTANCE
1,VINCULIN

(Homo sapiens) 		PF00018
(SH3_1) 		4 SER A  49
GLY A  44
ASP A  38
GLY A  59
 None
 0.93A 5cdnC-5o2qA:
undetectable
5cdnD-5o2qA:
undetectable		 5cdnC-5o2qA:
12.86
5cdnD-5o2qA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 4 SER A 120
ASP A 189
ARG A 191
GLY A 126
 None
 0.93A 5cdnC-5ohsA:
undetectable
5cdnD-5ohsA:
undetectable		 5cdnC-5ohsA:
undetectable
5cdnD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLU A 276
GLY A 320
ARG A 319
GLY A 341
 None
None
GTR  A 608 (-3.0A)
None
 0.95A 5cdnC-5olsA:
undetectable
5cdnD-5olsA:
undetectable		 5cdnC-5olsA:
20.53
5cdnD-5olsA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C

(Methanothermobacter
wolfeii) 		PF01493
(GXGXG) 		4 GLY C  71
ASP C  70
ARG C  91
GLY C  92
 None
 0.91A 5cdnC-5t5iC:
undetectable
5cdnD-5t5iC:
undetectable		 5cdnC-5t5iC:
21.10
5cdnD-5t5iC:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 GLU A 327
GLY A 430
ASP A 434
ARG A 429
 None
 0.83A 5cdnC-5ur2A:
3.0
5cdnD-5ur2A:
undetectable		 5cdnC-5ur2A:
20.40
5cdnD-5ur2A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		4 SER A 322
GLY A 310
ASP A 199
ARG A 311
 None
 0.73A 5cdnC-5usdA:
undetectable
5cdnD-5usdA:
undetectable		 5cdnC-5usdA:
21.67
5cdnD-5usdA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN

(Zea mays) 		PF07714
(Pkinase_Tyr) 		4 SER A 909
ASP A 837
ARG A 821
GLY A 822
 None
 0.95A 5cdnC-5uv4A:
2.3
5cdnD-5uv4A:
undetectable		 5cdnC-5uv4A:
21.95
5cdnD-5uv4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF

(Shewanella
oneidensis) 		no annotation 5 SER B  95
GLY B 182
ASP B 181
ARG B 106
GLY B 104
 None
 1.34A 5cdnC-5vrfB:
5.5
5cdnD-5vrfB:
undetectable		 5cdnC-5vrfB:
9.93
5cdnD-5vrfB:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 4 GLU A 213
GLY A 115
ASP A 116
ARG A 121
 None
None
None
GOL  A 603 (-3.3A)
 0.94A 5cdnC-5w1eA:
2.2
5cdnD-5w1eA:
undetectable		 5cdnC-5w1eA:
10.89
5cdnD-5w1eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE

(Streptomyces
ribosidificus) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLU A 172
GLY A  90
ARG A 142
GLY A  88
 None
 0.95A 5cdnC-5w70A:
undetectable
5cdnD-5w70A:
undetectable		 5cdnC-5w70A:
22.93
5cdnD-5w70A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 4 SER A  77
GLU A  79
GLY A  45
GLY A 140
 None
 0.92A 5cdnC-5wdxA:
undetectable
5cdnD-5wdxA:
undetectable		 5cdnC-5wdxA:
22.31
5cdnD-5wdxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn PLATINUM SENSITIVITY
PROTEIN 3
SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A   2
GLY C  30
ASP C  31
ARG C  34
 None
 0.87A 5cdnC-5xynA:
undetectable
5cdnD-5xynA:
undetectable		 5cdnC-5xynA:
20.37
5cdnD-5xynA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 4 SER A 609
GLY A 421
ARG A 423
GLY A 337
 None
 0.92A 5cdnC-5ze3A:
undetectable
5cdnD-5ze3A:
undetectable		 5cdnC-5ze3A:
12.21
5cdnD-5ze3A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 4 GLU A 516
GLY A 168
ASP A 167
GLY A 374
 None
None
ZN  A 902 (-2.0A)
None
 0.89A 5cdnC-6c01A:
2.5
5cdnD-6c01A:
undetectable		 5cdnC-6c01A:
10.82
5cdnD-6c01A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 SER A 557
GLU A 536
GLY A 806
GLY A 843
 None
 0.93A 5cdnC-6eojA:
undetectable
5cdnD-6eojA:
undetectable		 5cdnC-6eojA:
16.32
5cdnD-6eojA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 4 GLU D 495
GLY D 463
ASP D 462
GLY D 505
 None
EDO  D 703 (-3.8A)
CA  D 709 ( 2.9A)
None
 0.78A 5cdnC-6eq8D:
5.0
5cdnD-6eq8D:
undetectable		 5cdnC-6eq8D:
11.14
5cdnD-6eq8D:
18.92