SIMILAR PATTERNS OF AMINO ACIDS FOR 5C8T_D_SAMD605_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak6 DESTRIN

(Homo sapiens;
Sus scrofa) 		PF00241
(Cofilin_ADF) 		5 ASP A 142
ALA A 137
GLN A 136
PHE A 102
CYH A 147
 None
 1.48A 5c8tD-1ak6A:
0.0		 5c8tD-1ak6A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 GLY A 148
ASN A 149
PRO A 150
ALA A 146
PHE A 145
 None
None
CA  A 601 ( 4.6A)
None
None
 1.48A 5c8tD-1j0hA:
0.5		 5c8tD-1j0hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		5 GLY A 183
ASN A 184
PRO A 185
ALA A 181
GLN A 180
 None
 1.31A 5c8tD-2g4bA:
undetectable		 5c8tD-2g4bA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		5 GLY A 183
ASN A 184
PRO A 185
ALA A 181
GLN A 180
 None
 1.30A 5c8tD-2yh0A:
0.3		 5c8tD-2yh0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab0 BCLA PROTEIN
ANTIBODY SCFV
FRAGMENT, HEAVY
CHAIN

(Bacillus
anthracis;
Mus musculus) 		no annotation
PF07686
(V-set) 		5 GLY B 100
ASN B  98
ASP A 122
ALA A 123
GLN A 120
 None
 1.35A 5c8tD-3ab0B:
0.0		 5c8tD-3ab0B:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sul CERATO-PLATANIN-LIKE
PROTEIN

(Moniliophthora
perniciosa) 		PF07249
(Cerato-platanin) 		5 TRP A  81
GLY A 119
ASN A 120
ALA A 117
GLN A 114
 None
 1.35A 5c8tD-3sulA:
0.0		 5c8tD-3sulA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE

(Aeromonas
jandaei) 		PF01212
(Beta_elim_lyase) 		5 GLY A  37
PRO A  36
ASP A  35
ALA A 233
GLN A 232
 None
 1.28A 5c8tD-3wgcA:
0.7		 5c8tD-3wgcA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbd BSHC

(Bacillus
subtilis) 		PF10079
(BshC) 		5 ASN A 199
ASP A 220
ALA A 219
GLN A 223
PHE A  67
 None
 1.41A 5c8tD-4wbdA:
0.6		 5c8tD-4wbdA:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c8s GUANINE-N7
METHYLTRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		10 TRP B 292
GLY B 333
ASN B 334
PRO B 335
ASP B 352
ALA B 353
GLN B 354
PHE B 367
TRP B 385
CYH B 387
 None
SAH  B 605 (-3.3A)
SAH  B 605 (-4.1A)
SAH  B 605 (-3.8A)
SAH  B 605 (-2.3A)
SAH  B 605 (-3.5A)
None
SAH  B 605 (-3.5A)
G3A  B 606 ( 4.1A)
SAH  B 605 ( 3.8A)
 0.71A 5c8tD-5c8sB:
45.9		 5c8tD-5c8sB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k39 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		5 GLY A  88
PRO A  44
ALA A  49
GLN A  48
PHE A  58
 None
 1.38A 5c8tD-5k39A:
undetectable		 5c8tD-5k39A:
15.37