SIMILAR PATTERNS OF AMINO ACIDS FOR 5C6O_A_4YHA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 MET A  33
ASN A  37
MET A  64
PHE A 150
PHE A 154
 None
 0.92A 5c6oA-4lz6A:
65.6		 5c6oA-4lz6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		6 MET A  33
TYR A  36
ASN A  37
MET A  63
MET A  67
GLN A 252
 None
 0.91A 5c6oA-4lz6A:
65.6		 5c6oA-4lz6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		7 MET A  33
TYR A  36
ASN A  37
MET A  64
MET A  67
PHE A 154
GLN A 252
 None
 0.67A 5c6oA-4lz6A:
65.6		 5c6oA-4lz6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 770
MET A 845
MET A 840
PHE A 835
GLN A 842
 CV7  A1987 (-3.1A)
CV7  A1987 (-4.6A)
CV7  A1987 ( 3.7A)
None
None
 1.34A 5c6oA-4udbA:
2.1		 5c6oA-4udbA:
20.52